Brief Information of the Compound and Protein
Compound Name
Methyl 4-((4-((4-(4-Cyano-2,6-dimethylphenoxy)thieno[2,3-d]-pyrimidin-2-yl)amino)piperidin-1-yl)methyl)benzoate
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PubChem ID
CID: 129909698
Canonical SMILES
COC(=O)c1ccc(CN2CCC(Nc3nc(Oc4c(C)cc(C#N)cc4C)c4ccsc4n3)CC2)cc1
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Compound Formula C29H29N5O3S
Compound Structure
Protein Name
Reverse transcriptase/RNaseH
Protein Classification
Enzyme
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Hydrolase
Uniprot ID
Q72547
Gene Name
POL
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000247 MT-4 Homo sapiens (Human)  7
1
EC50 = 29.1 nM
   TI
   LI
   LO
   TS
2
EC50 = 35.6 nM
   TI
   LI
   LO
   TS
3
EC50 = 90.7 nM
   TI
   LI
   LO
   TS
4
EC50 = 134 nM
   TI
   LI
   LO
   TS
5
EC50 = 158 nM
   TI
   LI
   LO
   TS
6
EC50 = 263 nM
   TI
   LI
   LO
   TS
7
EC50 = 15300 nM
   TI
   LI
   LO
   TS