Brief Information of the Compound and Protein
Compound Name
4-((4-((4-(4-Cyano-2,6-dimethylphenoxy)-5,5-dioxidothieno[3,2-d]pyrimidin-2-yl)amino)piperidin-1-yl)methyl)benzenesulfonamide
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PubChem ID
CID: 137658045
Canonical SMILES
Cc1cc(C#N)cc(C)c1Oc1nc(NC2CCC(NCc3ccc(S(C)(=O)=O)cc3)CC2)nc2c1S(=O)(=O)C=C2
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Compound Formula C29H31N5O5S2
Compound Structure
Protein Name
Reverse transcriptase/RNaseH
Protein Classification
Enzyme
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Hydrolase
Uniprot ID
Q72547
Gene Name
POL
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000247 MT-4 Homo sapiens (Human)  6
1
EC50 = 5.14 nM
   TI
   LI
   LO
   TS
2
EC50 = 13.6 nM
   TI
   LI
   LO
   TS
3
EC50 = 23.1 nM
   TI
   LI
   LO
   TS
4
EC50 = 24.6 nM
   TI
   LI
   LO
   TS
5
EC50 = 32.4 nM
   TI
   LI
   LO
   TS
6
EC50 = 189 nM
   TI
   LI
   LO
   TS