Brief Information of the Compound and Protein
Compound Name
Ethyl(E)-4-((4-((4-(4-(2-Cyanovinyl)-2,6-dimethylphenoxy)thieno-[3,2-d]pyrimidin-2-yl)amino)piperidin-1-yl)methyl)benzoate
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PubChem ID
CID: 129908706
Canonical SMILES
CCOC(=O)c1ccc(CN2CCC(Nc3nc(Oc4c(C)cc(/C=C/C#N)cc4C)c4sccc4n3)CC2)cc1
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Compound Formula C32H33N5O3S
Compound Structure
Protein Name
Reverse transcriptase/RNaseH
Protein Classification
Enzyme
>
Hydrolase
Uniprot ID
Q72547
Gene Name
POL
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000247 MT-4 Homo sapiens (Human)  7
1
EC50 = 13.2 nM
   TI
   LI
   LO
   TS
2
EC50 = 26.8 nM
   TI
   LI
   LO
   TS
3
EC50 = 32.9 nM
   TI
   LI
   LO
   TS
4
EC50 = 37.4 nM
   TI
   LI
   LO
   TS
5
EC50 = 85.2 nM
   TI
   LI
   LO
   TS
6
EC50 = 163 nM
   TI
   LI
   LO
   TS
7
EC50 = 165 nM
   TI
   LI
   LO
   TS