Brief Information of the Compound and Protein
Compound Name
(E)-4-((4-((4-(4-(2-Cyanovinyl)-2,6-dimethylphenoxy)thieno[3,2-d]pyrimidin-2-yl)amino)piperidin-1-yl)methyl)benzamide
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PubChem ID
CID: 129908853
Canonical SMILES
Cc1cc(/C=C/C#N)cc(C)c1Oc1nc(NC2CCN(Cc3ccc(C(N)=O)cc3)CC2)nc2ccsc12
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Compound Formula C30H30N6O2S
Compound Structure
Protein Name
Reverse transcriptase/RNaseH
Protein Classification
Enzyme
>
Hydrolase
Uniprot ID
Q72547
Gene Name
POL
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000247 MT-4 Homo sapiens (Human)  6
1
EC50 = 2.97 nM
   TI
   LI
   LO
   TS
2
EC50 = 7.2 nM
   TI
   LI
   LO
   TS
3
EC50 = 7.62 nM
   TI
   LI
   LO
   TS
4
EC50 = 8.14 nM
   TI
   LI
   LO
   TS
5
EC50 = 8.48 nM
   TI
   LI
   LO
   TS
6
EC50 = 10.8 nM
   TI
   LI
   LO
   TS