Bioactivity Information | MolBiC

Brief Information of the Compound and Protein

Compound Name

Compound Info

(AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione

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PubChem ID

CID: 35370

SID: 15221752

Canonical SMILES	Cc1cn([C@H]2C[C@H](N=[N+]=[N-])[C@@H](CO)O2)c(=O)[nH]c1=O Show/Hide
Compound Formula	C10H13N5O4

Compound Structure

Protein Name

Protein Info

Reverse transcriptase/RNaseH

Protein Classification

Enzyme

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Hydrolase

Uniprot ID

Q72547

Gene Name

POL

Table of Molecular Bioactivities Related to the Compound and Protein

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000108	CCRF-CEM Cell Line Info	Homo sapiens (Human)	1
1	EC50 = 3 nM	TI LI LO TS
CL000407	CEM-SS Cell Line Info	Homo sapiens (Human)	2
1	EC50 = 2 nM	TI LI LO TS
2	IC50 = 3.1 nM	TI LI LO TS
CL000262	MT-2 Cell Line Info	Homo sapiens (Human)	1
1	IC50 = 50 nM	TI LI LO TS
CL000247	MT-4 Cell Line Info	Homo sapiens (Human)	14
1	EC50 = 3 nM	TI LI LO TS
2	EC50 = 3.75 nM	TI LI LO TS
3	EC50 = 4.79 nM	TI LI LO TS
4	EC50 = 5.24 nM	TI LI LO TS
5	EC50 = 6.34 nM	TI LI LO TS
6	EC50 = 6.6 nM	TI LI LO TS
7	EC50 = 6.68 nM	TI LI LO TS
8	EC50 = 7 nM	TI LI LO TS
9	EC50 = 7.3 nM	TI LI LO TS
10	EC50 = 8 nM	TI LI LO TS
11	EC50 = 8.9 nM	TI LI LO TS
12	EC50 = 11.1 nM	TI LI LO TS
13	EC50 = 17 nM	TI LI LO TS
14	EC50 = 38 nM	TI LI LO TS

Biochemical Assays

1	EC50 = 3 nM
2	EC50 = 10 nM
3	IC50 = 3 nM
4	IC50 = 6 nM
5	IC50 = 10 nM
6	IC50 = 11 nM
7	IC50 = 12.722646 nM
8	IC50 = 17 nM
9	IC50 = 40 nM
10	IC50 = 50 nM
11	IC50 = 4540 nM
12	IC50 = 18220 nM
13	IC50 = 20140 nM
14	IC50 = 20520 nM
15	IC50 = 21430 nM
16	IC50 > 100000 nM
17	Kd = 5.4 nM