Brief Information of the Compound and Protein
Compound Name
(E)-3-(3,5-Dimethyl-4-((2-((1-(4-(methylsulfonyl)benzyl)piperidin-4-yl)amino)thieno[3,2-d]pyrimidin-4-yl)oxy)phenyl)acrylonitrile
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PubChem ID
CID: 129908852
Canonical SMILES
Cc1cc(/C=C/C#N)cc(C)c1Oc1nc(NC2CCN(Cc3ccc(S(C)(=O)=O)cc3)CC2)nc2ccsc12
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Compound Formula C30H31N5O3S2
Compound Structure
Protein Name
Reverse transcriptase/RNaseH
Protein Classification
Enzyme
>
Hydrolase
Uniprot ID
Q72547
Gene Name
POL
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000247 MT-4 Homo sapiens (Human)  6
1
EC50 = 2.97 nM
   TI
   LI
   LO
   TS
2
EC50 = 4.51 nM
   TI
   LI
   LO
   TS
3
EC50 = 4.67 nM
   TI
   LI
   LO
   TS
4
EC50 = 4.68 nM
   TI
   LI
   LO
   TS
5
EC50 = 5.62 nM
   TI
   LI
   LO
   TS
6
EC50 = 7.93 nM
   TI
   LI
   LO
   TS