Brief Information of the Compound and Protein
Compound Name
4-[2-[[1-(1H-imidazol-5-ylmethyl)piperidin-4-yl]amino]thieno[3,2-d]pyrimidin-4-yl]oxy-3,5-dimethylbenzonitrile
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PubChem ID
CID: 145982341
Canonical SMILES
Cc1cc(cc(C)c1Oc1nc(NC2CCN(Cc3c[nH]cn3)CC2)nc2ccsc12)C#N
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Compound Formula C24H25N7OS
Compound Structure
Protein Name
Reverse transcriptase/RNaseH
Protein Classification
Enzyme
>
Hydrolase
Uniprot ID
Q72547
Gene Name
POL
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000247 MT-4 Homo sapiens (Human)  5
1
EC50 = 5.49 nM
   TI
   LI
   LO
   TS
2
EC50 = 5.98 nM
   TI
   LI
   LO
   TS
3
EC50 = 12 nM
   TI
   LI
   LO
   TS
4
EC50 = 1168 nM
   TI
   LI
   LO
   TS
5
IC50 = 52 nM
   TI
   LI
   LO
   TS