| Compound ID |
Compound Name |
Compound Formula |
|
CP0059270
|
4-[3-[2-chloro-6-(trifluoromethyl)benzoyl]imidazo[1,5-a]pyridin-1-yl]-2-hydroxybenzoic acid
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|
C22H12ClF3N2O4
|
1
|
| 1 |
EC50 = 4 nM
|
|
|
|
CP0424265
|
N-(2-methylpropyl)-4-[(1-methylsulfonylpiperidin-4-yl)amino]-N-[[2-(trifluoromethyl)phenyl]methyl]benzenesulfonamide
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|
C24H32F3N3O4S2
|
1
|
| 1 |
EC50 = 6 nM
|
|
|
|
CP0060047
|
N-[4-(5-acetamido-2-propan-2-ylpyrazol-3-yl)-2-piperidin-1-ylphenyl]-2-chloro-6-fluoro-N-(trideuteriomethyl)benzamide
Show/Hide
|
C27H31ClFN5O2
|
1
|
| 1 |
EC50 = 6 nM
|
|
|
|
CP0770850
|
N-(4-(3-acetamido-1-isopropyl-1H-pyrazol-5-yl)-2-(3-azabicyclo[3.1.0]hexan-3-yl)phenyl)-2,6-dichloro-N-[2H]-methylbenzamide
Show/Hide
|
C27H29Cl2N5O2
|
1
|
| 1 |
EC50 = 6.1 nM
|
|
|
|
CP0424261
|
N-(2-methylpropyl)-4-[(1-methylsulfonylpiperidin-4-yl)amino]-N-[2-(trifluoromethyl)phenyl]benzenesulfonamide
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|
C23H30F3N3O4S2
|
1
|
| 1 |
EC50 = 7 nM
|
|
|
|
CP0694116
|
N-(2-(3-azabicyclo[3.1.0]hexan-3-yl)-4-(3-(cyclopropanecarboxamido)-1-isopropyl-1H-pyrazol-5-yl)phenyl)-2-chloro-6-fluoro-N[2H]-methylbenzamide
Show/Hide
|
C29H31ClFN5O2
|
1
|
| 1 |
EC50 = 7.6 nM
|
|
|
|
CP0563763
|
N-[4-(5-carbamoyl-2-chlorophenyl)-2-piperidin-1-ylphenyl]-2-chloro-6-fluoro-N-methylbenzamide
Show/Hide
|
C26H24Cl2FN3O2
|
1
|
| 1 |
EC50 = 8 nM
|
|
|
|
CP0674649
|
N-(4-(3-acetamido-1-isopropyl-1H-pyrazol-5-yl)-2-(3-azabicyclo[3.1.0]hexan-3-yl)phenyl)-2-chloro-6-fluoro-N-[2H]-methylbenzamide
Show/Hide
|
C27H29ClFN5O2
|
1
|
| 1 |
EC50 = 8.1 nM
|
|
|
|
CP0731677
|
N-(4-(3-acetamido-1-cyclopentyl-1H-pyrazol-5-yl)-2-(3-azabicyclo[3.1.0]hexan-3-yl)phenyl)-2-chloro-6-fluoro-N[2H]-methylbenzamide
Show/Hide
|
C29H31ClFN5O2
|
1
|
| 1 |
EC50 = 9.5 nM
|
|
|
|
CP0199396
|
N-[4-(5-acetamido-2-propan-2-ylpyrazol-3-yl)-2-(3-azabicyclo[3.1.0]hexan-3-yl)phenyl]-2-chloro-6-fluoro-N-methylbenzamide
Show/Hide
|
C27H29ClFN5O2
|
1
|
| 1 |
EC50 = 10 nM
|
|
|
|
CP0281543
|
N-[5-(2-acetamido-4-propan-2-yl-1,3-thiazol-5-yl)-3-piperidin-1-ylpyridin-2-yl]-2-chloro-6-fluoro-N-methylbenzamide
Show/Hide
|
C26H29ClFN5O2S
|
1
|
| 1 |
EC50 = 10 nM
|
|
|
|
CP0385849
|
4-[3-[2-chloro-6-(trifluoromethyl)benzoyl]imidazo[1,5-a]pyridin-1-yl]-3-fluorobenzoic acid
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|
C22H11ClF4N2O3
|
1
|
| 1 |
EC50 = 10 nM
|
|
|
|
CP0660102
|
N-(4-(3-acetamido-1-isopropyl-1H-pyrazol-5-yl)-2-(3-azabicyclo[3.1.0]hexan-3-yl)phenyl)-2-fluoro-N[2H],6-dimethylbenzamide
Show/Hide
|
C28H32FN5O2
|
1
|
| 1 |
EC50 = 12 nM
|
|
|
|
CP0674427
|
N-(4-(3-acetamido-1-(cyclopropylmethyl)-1H-pyrazol-5-yl)-2-(3-azabicyclo[3.1.0]hexan-3-yl)phenyl)-2-chloro-6-fluoro-N[2H]-methylbenzamide
Show/Hide
|
C28H29ClFN5O2
|
1
|
| 1 |
EC50 = 12 nM
|
|
|
|
CP0830825
|
N-(2-(3-azabicyclo[3.1.0]hexan-3-yl)-4-(3-((1r,3r)-3-hydroxycyclobutanecarboxamido)-1-isopropyl-1H-pyrazol-5-yl)phenyl)-2-chloro-6-fluoro-N[2H]-methylbenzamide
Show/Hide
|
C30H33ClFN5O3
|
1
|
| 1 |
EC50 = 12 nM
|
|
|
|
CP0145639
|
N-[4-(5-carbamoyl-2-chlorophenyl)-2-(diethylamino)phenyl]-2-chloro-6-fluoro-N-methylbenzamide
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|
C25H24Cl2FN3O2
|
1
|
| 1 |
EC50 = 12 nM
|
|
|
|
CP0072489
|
N-[5-(5-acetamido-2-propan-2-ylpyrazol-3-yl)-3-piperidin-1-ylpyridin-2-yl]-2-chloro-6-fluoro-N-methylbenzamide
Show/Hide
|
C26H30ClFN6O2
|
1
|
| 1 |
EC50 = 13 nM
|
|
|
|
CP0659888
|
N-(4-(3-acetamido-1-cyclobutyl-1H-pyrazol-5-yl)-2-(3-azabicyclo[3.1.0]hexan-3-yl)phenyl)-2-chloro-6-fluoro-N[2H]-methylbenzamide
Show/Hide
|
C28H29ClFN5O2
|
1
|
| 1 |
EC50 = 13 nM
|
|
|
|
CP0258549
|
4-[6-(2-chloro-6-cyclopropylbenzoyl)imidazo[1,5-a]pyrimidin-8-yl]-2-hydroxybenzoic acid
Show/Hide
|
C23H16ClN3O4
|
1
|
| 1 |
EC50 = 13 nM
|
|
|
|
CP0385839
|
4-[3-[2-chloro-6-(trifluoromethyl)benzoyl]imidazo[1,5-a]pyridin-1-yl]benzoic acid
Show/Hide
|
C22H12ClF3N2O3
|
1
|
| 1 |
EC50 = 13 nM
|
|
|
|
CP0717530
|
N-(2-(3-azabicyclo[3.1.0]hexan-3-yl)-4-(1-isopropyl-3-propionamido-1H-pyrazol-5-yl)phenyl)-2-chloro-6-fluoro-N[2H]-methylbenzamide
Show/Hide
|
C28H31ClFN5O2
|
1
|
| 1 |
EC50 = 14 nM
|
|
|
|
CP0382327
|
N-[2-(3-azabicyclo[3.1.0]hexan-3-yl)-4-[5-[(3-hydroxycyclobutanecarbonyl)amino]-2-propan-2-ylpyrazol-3-yl]phenyl]-2-chloro-6-fluoro-N-(trideuteriomethyl)benzamide
Show/Hide
|
C30H33ClFN5O3
|
1
|
| 1 |
EC50 = 15 nM
|
|
|
|
CP0806353
|
N-(2-(3-azabicyclo[3.1.0]hexan-3-yl)-4-(3-(2-hydroxyacetamido)-1-isopropyl-1H-pyrazol-5-yl)phenyl)-2-chloro-6-fluoro-N-[2H]-methylbenzamide
Show/Hide
|
C27H29ClFN5O3
|
1
|
| 1 |
EC50 = 15 nM
|
|
|
|
CP0849524
|
N-(2-(3-azabicyclo[3.1.0]hexan-3-yl)-4-(3-isobutyramido-1-isopropyl-1H-pyrazol-5-yl)phenyl)-2-chloro-6-fluoro-N[2H]-methylbenzamide
Show/Hide
|
C29H33ClFN5O2
|
1
|
| 1 |
EC50 = 15 nM
|
|
|
|
CP0660103
|
N-(4-(3-acetamido-1-(1-cyclopropylethyl)-1H-pyrazol-5-yl)-2-(3-azabicyclo[3.1.0]hexan-3-yl)phenyl)-2-chloro-6-fluoro-N[2H]-methylbenzamide
Show/Hide
|
C29H31ClFN5O2
|
1
|
| 1 |
EC50 = 17 nM
|
|
|
|
CP0281549
|
N-[4-(5-acetamido-2-propan-2-ylpyrazol-3-yl)-2-pyrrolidin-1-ylphenyl]-2-chloro-6-fluoro-N-(trideuteriomethyl)benzamide
Show/Hide
|
C26H29ClFN5O2
|
1
|
| 1 |
EC50 = 18 nM
|
|
|
|
CP0424263
|
N-(4-fluorophenyl)-N-(2-methylpropyl)-4-(1-methylsulfonylpiperidin-4-yl)oxybenzenesulfonamide
Show/Hide
|
C22H29FN2O5S2
|
1
|
| 1 |
EC50 = 19 nM
|
|
|
|
CP0717531
|
N-(5-(3-(3-azabicyclo[3.1.0]hexan-3-yl)-4-(2-chloro-6-fluoro-N[2H]-methylbenzamido)phenyl)-1-isopropyl-1H-pyrazol-3-yl)-3-hydroxyazetidine-1-carboxamide
Show/Hide
|
C29H32ClFN6O3
|
1
|
| 1 |
EC50 = 21 nM
|
|
|
|
CP0731675
|
N-(5-(3-(3-azabicyclo[3.1.0]hexan-3-yl)-4-(2-chloro-6-fluoro-N[2H]-methylbenzamido)phenyl)-1-isopropyl-1H-pyrazol-3-yl)-2-oxa-6-azaspiro[3.3]heptane-6-carboxamide
Show/Hide
|
C31H34ClFN6O3
|
1
|
| 1 |
EC50 = 22 nM
|
|
|
|
CP0788336
|
N-(2-(3-azabicyclo[3.1.0]hexan-3-yl)-4-(3-formamido-1-isopropyl-1H-pyrazol-5-yl)phenyl)-2-chloro-6-fluoro-N[2H]-methylbenzamide
Show/Hide
|
C26H27ClFN5O2
|
1
|
| 1 |
EC50 = 22 nM
|
|
|
|
CP0770851
|
N-(2-(3-azabicyclo[3.1.0]hexan-3-yl)-4-(1-isopropyl-3-(3-methylureido)-1H-pyrazol-5-yl)phenyl)-2-chloro-6-fluoro-N[2H]-methylbenzamide
Show/Hide
|
C27H30ClFN6O2
|
1
|
| 1 |
EC50 = 25 nM
|
|
|
|
CP0109853
|
4-[3-(2-chloro-6-cyclopropylbenzoyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-1-yl]-3-fluorobenzoic acid
Show/Hide
|
C24H20ClFN2O3
|
1
|
| 1 |
EC50 = 26 nM
|
|
|
|
CP0059556
|
N-[4-(5-acetamido-2-propan-2-ylpyrazol-3-yl)-2-(cyclobutylmethoxy)phenyl]-2-chloro-6-fluoro-N-(trideuteriomethyl)benzamide
Show/Hide
|
C27H30ClFN4O3
|
1
|
| 1 |
EC50 = 30 nM
|
|
|
|
CP0424264
|
N-(4-cyanophenyl)-N-(2-methylpropyl)-4-(1-methylsulfonylpiperidin-4-yl)oxybenzenesulfonamide
Show/Hide
|
C23H29N3O5S2
|
1
|
| 1 |
EC50 = 32 nM
|
|
|
|
CP0652292
|
N-(5-(3-acetamido-1-isopropyl-1H-pyrazol-5-yl)-3-(3-azabicyclo[3.1.0]hexan-3-yl)pyridin-2-yl)-2-chloro-6-fluoro-N-[2H]-methylbenzamide
Show/Hide
|
C26H28ClFN6O2
|
1
|
| 1 |
EC50 = 33 nM
|
|
|
|
CP0045770
|
4-[3-[2-chloro-6-(trifluoromethyl)benzoyl]-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-1-yl]-3-fluorobenzoic acid
Show/Hide
|
C22H15ClF4N2O3
|
1
|
| 1 |
EC50 = 36 nM
|
|
|
|
CP0660137
|
N-(2-(3-azabicyclo[3.1.0]hexan-3-yl)-4-(3-(3-(2-hydroxyethyl)ureido)-1-isopropyl-1H-pyrazol-5-yl)phenyl)-2-chloro-6-fluoro-N[2H]-methylbenzamide
Show/Hide
|
C28H32ClFN6O3
|
1
|
| 1 |
EC50 = 37 nM
|
|
|
|
CP0534352
|
[4-chloro-2-methoxy-3-(1,3-thiazol-2-ylmethoxy)quinolin-6-yl]-(2,6-dimethylpyridin-3-yl)-(3-methyltriazol-4-yl)methanol
Show/Hide
|
C25H23ClN6O3S
|
1
|
| 1 |
EC50 = 38 nM
|
|
|
|
CP0424262
|
N-(2-methylpropyl)-5-(1-methylsulfonylpiperidin-4-yl)oxy-N-[[2-(trifluoromethyl)phenyl]methyl]pyridine-2-sulfonamide
Show/Hide
|
C23H30F3N3O5S2
|
1
|
| 1 |
EC50 = 39 nM
|
|
|
|
CP0045843
|
N-[4-(5-acetamido-2-propan-2-ylpyrazol-3-yl)-2-phenylphenyl]-2-chloro-6-fluoro-N-(trideuteriomethyl)benzamide
Show/Hide
|
C28H26ClFN4O2
|
1
|
| 1 |
EC50 = 49 nM
|
|
|
|
CP0461701
|
[4-chloro-2-methoxy-3-(4-methylsulfonylphenyl)quinolin-6-yl]-(3-methylimidazol-4-yl)-[6-(trifluoromethyl)pyridin-3-yl]methanol
Show/Hide
|
C28H22ClF3N4O4S
|
1
|
| 1 |
EC50 = 49 nM
|
|
|
|
CP0660138
|
N-(4-(3-acetamido-1-neopentyl-1H-pyrazol-5-yl)-2-(3-azabicyclo[3.1.0]hexan-3-yl)phenyl)-2-chloro-6-fluoro-N[2H]-methylbenzamide
Show/Hide
|
C29H33ClFN5O2
|
1
|
| 1 |
EC50 = 55 nM
|
|
|
|
CP0830828
|
isopropyl 5-(3-(3-azabicyclo[3.1.0]hexan-3-yl)-4-(2-chloro-6-fluoro-N[2H]-methylbenzamido)phenyl)-1-isopropyl-1H-pyrazol-3-ylcarbamate
Show/Hide
|
C29H33ClFN5O3
|
1
|
| 1 |
EC50 = 57 nM
|
|
|
|
CP0224309
|
N-[4-(5-carbamoyl-2-chlorophenyl)-2-propoxyphenyl]-2-chloro-6-fluoro-N-methylbenzamide
Show/Hide
|
C24H21Cl2FN2O3
|
1
|
| 1 |
EC50 = 58 nM
|
|
|
|
CP0528744
|
N-[5-(5-carbamoyl-2-chlorophenyl)-3-(cyclobutylmethoxy)pyridin-2-yl]-2-chloro-6-fluoro-N-methylbenzamide
Show/Hide
|
C25H22Cl2FN3O3
|
1
|
| 1 |
EC50 = 58 nM
|
|
|
|
CP0946875
|
[2H]-N-(5-(5-carbamoyl-2-chlorophenyl)-3-(cyclobutylmethoxy)pyridin-2-yl)-2-chloro-6-fluoro-N-methylbenzamide
Show/Hide
|
C25H22Cl2FN3O3
|
1
|
| 1 |
EC50 = 60 nM
|
|
|
|
CP0480892
|
N-[2-(3-azabicyclo[3.1.0]hexan-3-yl)-4-[5-(1,3-dihydroxypropan-2-ylcarbamoylamino)-2-propan-2-ylpyrazol-3-yl]phenyl]-2-chloro-6-fluoro-N-(trideuteriomethyl)benzamide
Show/Hide
|
C29H34ClFN6O4
|
1
|
| 1 |
EC50 = 71 nM
|
|
|
|
CP0677744
|
N-(4-(3-acetamido-1-(oxetan-3-yl)-1H-pyrazol-5-yl)-2-(3-azabicyclo[3.1.0]hexan-3-yl)phenyl)-2-chloro-6-fluoro-N[2H]-methylbenzamide
Show/Hide
|
C27H27ClFN5O3
|
1
|
| 1 |
EC50 = 76 nM
|
|
|
|
CP0830827
|
N-(2-(3-azabicyclo[3.1.0]hexan-3-yl)-4-(3-(2-(dimethylamino)acetamido)-1-isopropyl-1H-pyrazol-5-yl)phenyl)-2-chloro-6-fluoro-N-[2H]-methylbenzamide
Show/Hide
|
C29H34ClFN6O2
|
1
|
| 1 |
EC50 = 93 nM
|
|
|
|
CP0718057
|
6-chloro-4'-(2-chloro-6-fluoro-N-methylbenzamido)-3'-(2,2,2-trifluoroethoxy)biphenyl-3-carboxamide
Show/Hide
|
C23H16Cl2F4N2O3
|
1
|
| 1 |
EC50 = 93 nM
|
|
|
|
CP0045935
|
N-[4-(5-carbamoyl-2-chlorophenyl)-2-(2,2,2-trifluoroethoxy)phenyl]-2-chloro-6-fluoro-N-(trideuteriomethyl)benzamide
Show/Hide
|
C23H16Cl2F4N2O3
|
2
|
| 1 |
EC50 = 97 nM
|
|
|
| 2 |
EC50 = 98 nM
|
|
|
|
CP0247153
|
N-[2-butoxy-4-(5-carbamoyl-2-chlorophenyl)phenyl]-2-chloro-6-fluoro-N-methylbenzamide
Show/Hide
|
C25H23Cl2FN2O3
|
1
|
| 1 |
EC50 = 101 nM
|
|
|
|
CP0060756
|
3-[(2S)-6-[3-(difluoromethoxy)-5-fluorophenyl]-4-[3-(trifluoromethyl)phenyl]sulfonyl-2,3-dihydro-1,4-benzoxazin-2-yl]-2,2-dimethylpropanoic acid
Show/Hide
|
C27H23F6NO6S
|
1
|
| 1 |
EC50 = 102 nM
|
|
|
|
CP0451260
|
N-[(5-methylsulfonylpyridin-2-yl)methyl]-4-[2-(6-propan-2-yloxy-2,3-dihydro-1,4-benzoxazin-4-yl)ethyl]benzamide
Show/Hide
|
C27H31N3O5S
|
1
|
| 1 |
EC50 = 107 nM
|
|
|
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CP0253451
|
N-[[4-(4-acetylpiperazin-1-yl)phenyl]methyl]-N-(2-methylpropyl)-1-phenylmethanesulfonamide
Show/Hide
|
C24H33N3O3S
|
1
|
| 1 |
EC50 = 120 nM
|
|
|
|
CP0052231
|
N-[[4-(4-acetylpiperazin-1-yl)phenyl]methyl]-N-cyclobutyl-1-phenylmethanesulfonamide
Show/Hide
|
C24H31N3O3S
|
1
|
| 1 |
EC50 = 130 nM
|
|
|
|
CP0773205
|
N-(4-(3-acetamido-1-isopropyl-1H-pyrazol-5-yl)-2-(bicyclo[3.1.0]hexan-3-yloxy)phenyl)-2-chloro-6-fluoro-N-[2H]-methylbenzamide
Show/Hide
|
C28H30ClFN4O3
|
1
|
| 1 |
EC50 = 130 nM
|
|
|
|
CP0558424
|
N-[(5-ethylsulfonylpyridin-2-yl)methyl]-4-[2-(6-propan-2-yloxy-2,3-dihydro-1,4-benzoxazin-4-yl)ethyl]benzamide
Show/Hide
|
C28H33N3O5S
|
1
|
| 1 |
EC50 = 135.4 nM
|
|
|
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CP0365040
|
4-chloro-5-[1-(2-chloro-6-fluorobenzoyl)-3,4-dihydro-2H-quinolin-6-yl]-2-fluorobenzamide
Show/Hide
|
C23H16Cl2F2N2O2
|
1
|
| 1 |
EC50 = 140 nM
|
|
|
|
CP0428548
|
(1-methylcyclopropyl) N-[5-[3-(3-azabicyclo[3.1.0]hexan-3-yl)-4-[(2-chloro-6-fluorobenzoyl)-(trideuteriomethyl)amino]phenyl]-1-propan-2-ylpyrazol-3-yl]carbamate
Show/Hide
|
C30H33ClFN5O3
|
1
|
| 1 |
EC50 = 150 nM
|
|
|
|
CP0567797
|
2-(4-ethylsulfonylphenyl)-N-[4-[2-[7-(2-methylpropyl)-3,4-dihydro-2H-quinolin-1-yl]ethyl]phenyl]acetamide
Show/Hide
|
C31H38N2O3S
|
1
|
| 1 |
EC50 = 154 nM
|
|
|
|
CP0088476
|
N-[4-(5-acetamido-2-propan-2-ylpyrazol-3-yl)-2-(2,2,2-trifluoroethoxy)phenyl]-2-chloro-6-fluoro-N-(trideuteriomethyl)benzamide
Show/Hide
|
C24H23ClF4N4O3
|
1
|
| 1 |
EC50 = 160 nM
|
|
|
|
CP0146700
|
2-chloro-6-fluoro-N-[4-(1-methyl-5-propan-2-ylpyrazol-4-yl)-2-(2,2,2-trifluoroethoxy)phenyl]-N-(trideuteriomethyl)benzamide
Show/Hide
|
C23H22ClF4N3O2
|
1
|
| 1 |
EC50 = 160 nM
|
|
|
|
CP0404168
|
4-chloro-3-[1-(2-chloro-6-fluorobenzoyl)-3,4-dihydro-2H-quinolin-6-yl]-N-ethylbenzamide
Show/Hide
|
C25H21Cl2FN2O2
|
1
|
| 1 |
EC50 = 160 nM
|
|
|
|
CP0199395
|
N-[4-(5-acetamido-2-propan-2-ylpyrazol-3-yl)-2-(2-methylpropoxy)phenyl]-2-chloro-6-fluoro-N-(trideuteriomethyl)benzamide
Show/Hide
|
C26H30ClFN4O3
|
1
|
| 1 |
EC50 = 180 nM
|
|
|
|
CP0484672
|
N-[4-(5-carbamoyl-2-chlorophenyl)-2-ethoxyphenyl]-2-chloro-6-fluoro-N-methylbenzamide
Show/Hide
|
C23H19Cl2FN2O3
|
1
|
| 1 |
EC50 = 181 nM
|
|
|
|
CP0365042
|
N-[4-(5-carbamoyl-2-chlorophenyl)-2-propan-2-yloxyphenyl]-2-chloro-6-fluoro-N-methylbenzamide
Show/Hide
|
C24H21Cl2FN2O3
|
1
|
| 1 |
EC50 = 182 nM
|
|
|
|
CP0046607
|
4-chloro-3-[1-(2-chloro-6-fluorobenzoyl)-3,4-dihydro-2H-quinolin-6-yl]benzamide
Show/Hide
|
C23H17Cl2FN2O2
|
1
|
| 1 |
EC50 = 200 nM
|
|
|
|
CP0563762
|
4-chloro-3-[1-(2-chloro-6-fluorobenzoyl)-3,4-dihydro-2H-quinolin-6-yl]-N-methylbenzamide
Show/Hide
|
C24H19Cl2FN2O2
|
1
|
| 1 |
EC50 = 200 nM
|
|
|
|
CP0364216
|
2-[(2S)-6-[3-(difluoromethoxy)-5-fluorophenyl]-1-[3-(trifluoromethyl)phenyl]sulfonyl-2,3-dihydroindol-2-yl]acetic acid
Show/Hide
|
C24H17F6NO5S
|
1
|
| 1 |
EC50 = 201 nM
|
|
|
|
CP0078421
|
4-chloro-3-[1-(2-chloro-6-fluorobenzoyl)-3,4-dihydro-2H-quinolin-6-yl]-N-(2-hydroxyethyl)benzamide
Show/Hide
|
C25H21Cl2FN2O3
|
1
|
| 1 |
EC50 = 210 nM
|
|
|
|
CP0101389
|
4-chloro-3-[1-(2-chloro-6-fluorobenzoyl)-4-methyl-2,3-dihydroquinoxalin-6-yl]benzamide
Show/Hide
|
C23H18Cl2FN3O2
|
1
|
| 1 |
EC50 = 210 nM
|
|
|
|
CP0189740
|
N-[(5-ethylsulfonylpyridin-2-yl)methyl]-4-[2-[7-(2-methylpropyl)-3,4-dihydro-2H-quinolin-1-yl]ethyl]benzamide
Show/Hide
|
C30H37N3O3S
|
1
|
| 1 |
EC50 = 241.9 nM
|
|
|
|
CP0702332
|
[2H]-N-(5-(5-carbamoyl-2-chlorophenyl)-3-(2,2,2-trifluoroethoxy)pyridin-2-yl)-2-chloro-6-fluoro-N-methylbenzamide
Show/Hide
|
C22H15Cl2F4N3O3
|
1
|
| 1 |
EC50 = 245 nM
|
|
|
|
CP0175229
|
N-[5-(5-carbamoyl-2-chlorophenyl)-3-(2,2,2-trifluoroethoxy)pyridin-2-yl]-2-chloro-6-fluoro-N-methylbenzamide
Show/Hide
|
C22H15Cl2F4N3O3
|
1
|
| 1 |
EC50 = 246 nM
|
|
|
|
CP0060417
|
2-[6-[3-(difluoromethoxy)-5-fluorophenyl]-1-[3-(trifluoromethyl)phenyl]sulfonyl-2,3-dihydroindol-2-yl]acetic acid
Show/Hide
|
C24H17F6NO5S
|
1
|
| 1 |
EC50 = 247 nM
|
|
|
|
CP0266018
|
N-[[4-(4-acetylpiperazin-1-yl)phenyl]methyl]-1-phenyl-N-(2,2,2-trifluoroethyl)methanesulfonamide
Show/Hide
|
C22H26F3N3O3S
|
1
|
| 1 |
EC50 = 270 nM
|
|
|
|
CP0484671
|
4-chloro-3-[1-(2-chloro-6-fluorobenzoyl)-4,4-dimethyl-2,3-dihydroquinolin-6-yl]benzamide
Show/Hide
|
C25H21Cl2FN2O2
|
1
|
| 1 |
EC50 = 300 nM
|
|
|
|
CP0060757
|
2-[6-[3-(difluoromethoxy)-5-fluorophenyl]-1-[3-(trifluoromethyl)phenyl]sulfonyl-2,3-dihydroindol-2-yl]-1-(1,1-dioxo-1,4-thiazinan-4-yl)ethanone
Show/Hide
|
C28H24F6N2O6S2
|
1
|
| 1 |
EC50 = 322 nM
|
|
|
|
CP0531958
|
US10201546, Example 66a
Show/Hide
|
C26H24ClN7O3
|
1
|
| 1 |
EC50 = 326 nM
|
|
|
|
CP0141347
|
4-chloro-3-[1-(2-chloro-6-fluorobenzoyl)-3,4-dihydro-2H-quinolin-6-yl]-N-cyclopentylbenzamide
Show/Hide
|
C28H25Cl2FN2O2
|
1
|
| 1 |
EC50 = 330 nM
|
|
|
|
CP0365046
|
N-[4-(5-carbamoyl-2-chlorophenyl)-2-ethylphenyl]-2-chloro-6-fluoro-N-methylbenzamide
Show/Hide
|
C23H19Cl2FN2O2
|
1
|
| 1 |
EC50 = 350 nM
|
|
|
|
CP0325717
|
N-[[4-(4-acetylpiperazin-1-yl)phenyl]methyl]-1-phenyl-N-propan-2-ylmethanesulfonamide
Show/Hide
|
C23H31N3O3S
|
1
|
| 1 |
EC50 = 410 nM
|
|
|
|
CP0354660
|
4-[6-[3-(difluoromethoxy)-5-fluorophenyl]-1-[3-(trifluoromethyl)phenyl]sulfonyl-2,3-dihydroindol-2-yl]butanoic acid
Show/Hide
|
C26H21F6NO5S
|
1
|
| 1 |
EC50 = 422 nM
|
|
|
|
CP0257822
|
N-(2-methylpropyl)-N-[[4-(4-methylsulfonylphenyl)phenyl]methyl]-1-phenylmethanesulfonamide
Show/Hide
|
C25H29NO4S2
|
2
|
| 1 |
EC50 = 450 nM
|
|
|
| 2 |
EC50 = 453 nM
|
|
|
|
CP0175226
|
4-chloro-3-[1-(2-chloro-6-fluorobenzoyl)-3,3-dimethyl-2,4-dihydroquinolin-6-yl]benzamide
Show/Hide
|
C25H21Cl2FN2O2
|
1
|
| 1 |
EC50 = 450 nM
|
|
|
|
CP0188108
|
3-[1-(2-chloro-6-fluorobenzoyl)-3,4-dihydro-2H-quinolin-6-yl]-4-methylbenzamide
Show/Hide
|
C24H20ClFN2O2
|
1
|
| 1 |
EC50 = 450 nM
|
|
|
|
CP0224311
|
N-[4-(5-carbamoyl-2-chlorophenyl)-2-(trifluoromethyl)phenyl]-2-chloro-6-fluoro-N-methylbenzamide
Show/Hide
|
C22H14Cl2F4N2O2
|
1
|
| 1 |
EC50 = 484 nM
|
|
|
|
CP0348513
|
4-chloro-3-[1-(2-chloro-6-fluorobenzoyl)-2,3,4,5-tetrahydro-1-benzazepin-7-yl]benzamide
Show/Hide
|
C24H19Cl2FN2O2
|
1
|
| 1 |
EC50 = 530 nM
|
|
|
|
CP0199394
|
5-[4-[(2-chloro-6-fluorobenzoyl)-(trideuteriomethyl)amino]-3-(2,2,2-trifluoroethoxy)phenyl]-1-propan-2-ylpyrazole-3-carboxamide
Show/Hide
|
C23H21ClF4N4O3
|
1
|
| 1 |
EC50 = 570 nM
|
|
|
|
CP0253044
|
N-[4-(5-carbamoyl-2-chlorophenyl)-2-(ethylamino)phenyl]-2-chloro-6-fluoro-N-methylbenzamide
Show/Hide
|
C23H20Cl2FN3O2
|
1
|
| 1 |
EC50 = 717 nM
|
|
|
|
CP0364061
|
2-[6-[3-(difluoromethoxy)-5-fluorophenyl]-1-[3-(trifluoromethyl)phenyl]sulfonyl-2,3-dihydroindol-2-yl]-1-(2-oxa-6-azaspiro[3.3]heptan-6-yl)ethanone
Show/Hide
|
C29H24F6N2O5S
|
1
|
| 1 |
EC50 = 752 nM
|
|
|
|
CP0365045
|
N-[2-bromo-4-(5-carbamoyl-2-chlorophenyl)phenyl]-2-chloro-6-fluoro-N-methylbenzamide
Show/Hide
|
C21H14BrCl2FN2O2
|
1
|
| 1 |
EC50 = 772 nM
|
|
|
|
CP0365048
|
N-[4-(5-carbamoyl-2-chlorophenyl)-2-methoxyphenyl]-2-chloro-6-fluoro-N-methylbenzamide
Show/Hide
|
C22H17Cl2FN2O3
|
1
|
| 1 |
EC50 = 984 nM
|
|
|
|
CP0343454
|
N-[4-[5-(2-amino-2-oxoethyl)-2-propan-2-ylpyrazol-3-yl]-2-(2,2,2-trifluoroethoxy)phenyl]-2-chloro-6-fluoro-N-(trideuteriomethyl)benzamide
Show/Hide
|
C24H23ClF4N4O3
|
1
|
| 1 |
EC50 = 1200 nM
|
|
|
|
CP0252385
|
2-chloro-6-fluoro-N-[4-(1-methyl-3-propan-2-ylpyrazol-4-yl)-2-(2,2,2-trifluoroethoxy)phenyl]-N-(trideuteriomethyl)benzamide
Show/Hide
|
C23H22ClF4N3O2
|
1
|
| 1 |
EC50 = 1700 nM
|
|
|
|
CP0354665
|
3-[6-[3-(difluoromethoxy)-5-fluorophenyl]-1-[3-(trifluoromethyl)phenyl]sulfonylindol-2-yl]propanoic acid
Show/Hide
|
C25H17F6NO5S
|
1
|
| 1 |
EC50 = 1710 nM
|
|
|
|
CP0364067
|
3-[6-[3-(difluoromethoxy)-5-fluorophenyl]-1-[3-(trifluoromethyl)phenyl]sulfonyl-2,3-dihydroindol-2-yl]propanoic acid
Show/Hide
|
C25H19F6NO5S
|
1
|
| 1 |
EC50 = 2320 nM
|
|
|
|
CP0366515
|
1-[2-[6-[3-(difluoromethoxy)-5-fluorophenyl]-1-[3-(trifluoromethyl)phenyl]sulfonyl-2,3-dihydroindol-2-yl]acetyl]azetidine-3-carboxylic acid
Show/Hide
|
C28H22F6N2O6S
|
1
|
| 1 |
EC50 = 4050 nM
|
|
|
|
CP0477503
|
1-[2-[6-[3-(difluoromethoxy)-5-fluorophenyl]-1-[3-(trifluoromethyl)phenyl]sulfonyl-2,3-dihydroindol-2-yl]acetyl]piperidine-4-carboxylic acid
Show/Hide
|
C30H26F6N2O6S
|
1
|
| 1 |
EC50 = 5440 nM
|
|
|
|
CP0354663
|
2-[6-[3-(difluoromethoxy)-5-fluorophenyl]-1-[3-(trifluoromethyl)phenyl]sulfonyl-2,3-dihydroindol-2-yl]-1-(4-hydroxypiperidin-1-yl)ethanone
Show/Hide
|
C29H26F6N2O5S
|
1
|
| 1 |
EC50 = 6040 nM
|
|
|
|
CP0089090
|
N-[5-(5-acetamido-2-propan-2-yl-1,2,4-triazol-3-yl)-3-piperidin-1-ylpyridin-2-yl]-2-chloro-6-fluoro-N-methylbenzamide
Show/Hide
|
C25H29ClFN7O2
|
1
|
| 1 |
EC50 > 1000 nM
|
|
|
|
CP0252387
|
N-[5-(4-acetamido-1-propan-2-ylimidazol-2-yl)-3-piperidin-1-ylpyridin-2-yl]-2-chloro-6-fluoro-N-methylbenzamide
Show/Hide
|
C26H30ClFN6O2
|
1
|
| 1 |
EC50 > 1000 nM
|
|
|
|
CP0521150
|
3-[5-[5-[2-(difluoromethyl)-3-fluoro-4-[[(2S)-1,1,1-trifluoropropan-2-yl]sulfamoyl]phenyl]-4-[(2S)-2-methylpiperidine-1-carbonyl]-1,3-thiazol-2-yl]-1,3,4-oxadiazol-2-yl]-2,2-dimethylpropanoic acid
Show/Hide
|
C27H29F6N5O6S2
|
1
|
| 1 |
IC50 = 0.1 nM
|
|
|
|
CP0249036
|
US10301272, Example 6/64
Show/Hide
|
C30H40N4O4S2
|
1
|
| 1 |
IC50 = 0.37 nM
|
|
|
|
CP0249037
|
US10301272, Example 6/11
Show/Hide
|
C30H39N3O4S2
|
1
|
| 1 |
IC50 = 0.69 nM
|
|
|
|
CP0389718
|
US10301272, Example 14/6
Show/Hide
|
C31H39N3O5S2
|
1
|
| 1 |
IC50 = 0.71 nM
|
|
|
|
CP0073529
|
US10301272, Example 7/9
Show/Hide
|
C30H37N3O5S2
|
2
|
| 1 |
IC50 = 0.94 nM
|
|
|
| 2 |
IC50 = 2 nM
|
|
|
|
CP0410681
|
5-[2,3-dichloro-4-[[(2S)-1,1,1-trifluoropropan-2-yl]sulfamoyl]phenyl]-4-[(4-fluorophenyl)methyl]-N-(2-hydroxy-2-methylpropyl)-1,3-thiazole-2-carboxamide
Show/Hide
|
C24H23Cl2F4N3O4S2
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
|
CP0074613
|
CHEMBL3314002
Show/Hide
|
C28H38ClN3O5S2
|
1
|
| 1 |
IC50 = 1.1 nM
|
|
|
|
CP0073551
|
US10301272, Example 8/7
Show/Hide
|
C30H36F3N3O4S
|
1
|
| 1 |
IC50 = 1.2 nM
|
|
|
|
CP0335291
|
2,3-dichloro-4-[4-(cyclobutylmethyl)-2-(2,2-dioxo-2lambda6-thia-6-azaspiro[3.3]heptane-6-carbonyl)-1,3-thiazol-5-yl]-N-[(2S)-1,1,1-trifluoropropan-2-yl]benzenesulfonamide
Show/Hide
|
C23H24Cl2F3N3O5S3
|
1
|
| 1 |
IC50 = 1.3 nM
|
|
|
|
CP0073466
|
US10301272, Example 7/8
Show/Hide
|
C30H41N3O5S2
|
1
|
| 1 |
IC50 = 1.4 nM
|
|
|
|
CP0199799
|
US10301272, Example 15
Show/Hide
|
C28H35N3O5S3
|
1
|
| 1 |
IC50 = 1.4 nM
|
|
|
|
CP0483134
|
US10301272, Example 20
Show/Hide
|
C31H38FN3O5S2
|
1
|
| 1 |
IC50 = 1.4 nM
|
|
|
|
CP0073467
|
US10301272, Example 7/7
Show/Hide
|
C26H33Cl2N3O5S2
|
1
|
| 1 |
IC50 = 1.6 nM
|
|
|
|
CP0430073
|
US10301272, Example 6/10
Show/Hide
|
C32H41N3O5S2
|
1
|
| 1 |
IC50 = 1.6 nM
|
|
|
|
CP0339634
|
3-[4-(cyclobutylmethyl)-5-[2,3-dichloro-4-[[(2S)-1,1,1-trifluorobutan-2-yl]sulfamoyl]phenyl]-1,3-thiazol-2-yl]-2,2-dimethylpropanoic acid
Show/Hide
|
C23H27Cl2F3N2O4S2
|
1
|
| 1 |
IC50 = 1.6 nM
|
|
|
|
CP0390452
|
CHEMBL4127282
Show/Hide
|
C29H32F3N3O5S2
|
1
|
| 1 |
IC50 = 1.8 nM
|
|
|
|
CP0456673
|
5-[4-(tert-butylsulfamoyl)naphthalen-1-yl]-4-(cyclohexylmethyl)-N-[(4-ethylsulfonylphenyl)methyl]-1,3-thiazole-2-carboxamide
Show/Hide
|
C34H41N3O5S3
|
1
|
| 1 |
IC50 = 1.8 nM
|
|
|
|
CP0111022
|
US10301272, Example 15/6
Show/Hide
|
C26H33Cl2N3O5S3
|
1
|
| 1 |
IC50 = 1.9 nM
|
|
|
|
CP0072572
|
US10301272, Example 6/19
Show/Hide
|
C26H36ClF2N3O4S2
|
1
|
| 1 |
IC50 = 2.6 nM
|
|
|
|
CP0074611
|
3-[[5-[3-chloro-2-(difluoromethyl)-4-(propan-2-ylsulfamoyl)phenyl]-4-(cyclohexylmethyl)-1,3-thiazole-2-carbonyl]amino]cyclobutane-1-carboxylic acid
Show/Hide
|
C26H32ClF2N3O5S2
|
1
|
| 1 |
IC50 = 2.6 nM
|
|
|
|
CP0268256
|
US10301272, Example 6/4
Show/Hide
|
C29H39N3O4S2
|
1
|
| 1 |
IC50 = 2.6 nM
|
|
|
|
CP0074608
|
US10301272, Example 7/13
Show/Hide
|
C28H37F2N3O6S2
|
1
|
| 1 |
IC50 = 3.2 nM
|
|
|
|
CP0339640
|
US10080744, Example 3/38
Show/Hide
|
C27H30F6N4O5S2
|
1
|
| 1 |
IC50 = 3.2 nM
|
|
|
|
CP0249286
|
CHEMBL4129634
Show/Hide
|
C27H28F3N3O5S2
|
1
|
| 1 |
IC50 = 3.4 nM
|
|
|
|
CP0369897
|
US10301272, Example 6/46
Show/Hide
|
C30H37N3O5S3
|
1
|
| 1 |
IC50 = 3.6 nM
|
|
|
|
CP0430095
|
US10301272, Example 15/8
Show/Hide
|
C29H37N3O5S3
|
1
|
| 1 |
IC50 = 3.6 nM
|
|
|
|
CP0557510
|
US10080744, Example 3/26
Show/Hide
|
C28H32F6N4O5S2
|
1
|
| 1 |
IC50 = 3.6 nM
|
|
|
|
CP0557575
|
3-[3-[4-(cyclobutylmethyl)-5-[2,3-dichloro-4-[[(2S)-1,1,1-trifluoropropan-2-yl]sulfamoyl]phenyl]-1,3-thiazol-2-yl]-1,2,4-oxadiazol-5-yl]-2,2-dimethylpropanoic acid
Show/Hide
|
C24H25Cl2F3N4O5S2
|
1
|
| 1 |
IC50 = 3.6 nM
|
|
|
|
CP0340360
|
US9290476, 77A
Show/Hide
|
C29H25ClF3N5O2
|
1
|
| 1 |
IC50 = 3.9 nM
|
|
|
|
CP0526829
|
3-[4-(cyclobutylmethyl)-5-[2,3-dichloro-4-[[(2S)-1,1,1-trifluoropropan-2-yl]sulfamoyl]phenyl]-1,3-thiazol-2-yl]-2,2-dimethylpropanoic acid
Show/Hide
|
C22H25Cl2F3N2O4S2
|
1
|
| 1 |
IC50 = 4.3 nM
|
|
|
|
CP0114877
|
US10301272, Example 8/4
Show/Hide
|
C29H34N4O4S2
|
1
|
| 1 |
IC50 = 4.4 nM
|
|
|
|
CP0389755
|
3-[[4-(cyclohexylmethyl)-5-[3-(1-methylcyclopropyl)-5-[[(2S)-1,1,1-trifluorobutan-2-yl]carbamoyl]phenyl]-1,3-thiazole-2-carbonyl]amino]cyclobutane-1-carboxylic acid
Show/Hide
|
C31H38F3N3O4S
|
1
|
| 1 |
IC50 = 4.7 nM
|
|
|
|
CP0553063
|
4-[3-(2,6-dichlorobenzoyl)indol-1-yl]-2-hydroxybenzoic acid
Show/Hide
|
C22H13Cl2NO4
|
1
|
| 1 |
IC50 = 5 nM
|
|
|
|
CP0557383
|
[4-chloro-2-methoxy-3-[[4-(trifluoromethyl)piperidin-1-yl]methyl]quinolin-6-yl]-(2,6-dimethylpyridin-4-yl)-(3-methyltriazol-4-yl)methanol
Show/Hide
|
C28H30ClF3N6O2
|
1
|
| 1 |
IC50 = 5.1 nM
|
|
|
|
CP0218446
|
4-[(3,3-difluorocyclobutyl)methyl]-N-(2-hydroxy-2-methylpropyl)-5-[4-[[(2S)-1,1,1-trifluoropropan-2-yl]sulfamoyl]naphthalen-1-yl]-1,3-thiazole-2-carboxamide
Show/Hide
|
C26H28F5N3O4S2
|
1
|
| 1 |
IC50 = 5.4 nM
|
|
|
|
CP0459062
|
(2,4-dichloro-3-phenylquinolin-6-yl)-(3-methylimidazol-4-yl)-quinolin-4-ylmethanol
Show/Hide
|
C29H20Cl2N4O
|
1
|
| 1 |
IC50 = 5.5 nM
|
|
|
|
CP0577120
|
US10080744, Example 3/3
Show/Hide
|
C28H29F3N4O5S2
|
1
|
| 1 |
IC50 = 6 nM
|
|
|
|
CP0073479
|
4-(cyclopropylmethyl)-N-(1,1-dioxothian-4-yl)-5-[4-[[(2S)-1,1,1-trifluoropropan-2-yl]sulfamoyl]naphthalen-1-yl]-1,3-thiazole-2-carboxamide
Show/Hide
|
C26H28F3N3O5S3
|
1
|
| 1 |
IC50 = 6.1 nM
|
|
|
|
CP0389716
|
CHEMBL4128427
Show/Hide
|
C29H38F3N3O5S2
|
1
|
| 1 |
IC50 = 6.3 nM
|
|
|
|
CP0321814
|
US9290476, 61
Show/Hide
|
C27H24ClN9O2
|
1
|
| 1 |
IC50 = 6.6 nM
|
|
|
|
CP0531616
|
US10301272, Example 300/11
Show/Hide
|
C27H35N3O5S3
|
1
|
| 1 |
IC50 = 7.1 nM
|
|
|
|
CP0180588
|
US10301272, Example 6/48
Show/Hide
|
C25H28F3N3O4S2
|
1
|
| 1 |
IC50 = 7.9 nM
|
|
|
|
CP0516618
|
3-[5-[5-[2-(difluoromethyl)-3-fluoro-4-[[(2S)-1,1,1-trifluoropropan-2-yl]sulfamoyl]phenyl]-4-[(4-fluorophenyl)methyl]-1,3-thiazol-2-yl]-1,3,4-oxadiazol-2-yl]-2,2-dimethylpropanoic acid
Show/Hide
|
C27H23F7N4O5S2
|
1
|
| 1 |
IC50 = 8 nM
|
|
|
|
CP0553969
|
3-[3-[4-(cyclobutylmethyl)-5-[2,3-dichloro-4-[[(2S)-1,1,1-trifluoropropan-2-yl]sulfamoyl]phenyl]-1,3-thiazol-2-yl]-1,2-oxazol-5-yl]-2,2-dimethylpropanoic acid
Show/Hide
|
C25H26Cl2F3N3O5S2
|
1
|
| 1 |
IC50 = 8 nM
|
|
|
|
CP0086254
|
N-tert-butyl-4-[4-(cyclohexylmethyl)-2-(7,7-dioxo-7lambda6-thia-2-azaspiro[3.5]nonane-2-carbonyl)-1,3-thiazol-5-yl]naphthalene-1-sulfonamide
Show/Hide
|
C32H41N3O5S3
|
1
|
| 1 |
IC50 = 8.7 nM
|
|
|
|
CP0451566
|
US10301272, Example 6/17
Show/Hide
|
C31H37N3O5S2
|
1
|
| 1 |
IC50 = 8.9 nM
|
|
|
|
CP0321517
|
3-[5-[5-[2-(difluoromethyl)-3-fluoro-4-[[(2S)-1,1,1-trifluoropropan-2-yl]sulfamoyl]phenyl]-4-(2-methylpropyl)-1,3-thiazol-2-yl]-1,3,4-oxadiazol-2-yl]-2,2-dimethylpropanoic acid
Show/Hide
|
C24H26F6N4O5S2
|
1
|
| 1 |
IC50 = 9 nM
|
|
|
|
CP0478055
|
3-[[5-[3-tert-butyl-5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-4-(cyclohexylmethyl)-1,3-thiazole-2-carbonyl]amino]cyclobutane-1-carboxylic acid
Show/Hide
|
C29H34F6N2O4S
|
1
|
| 1 |
IC50 = 9.4 nM
|
|
|
|
CP0480114
|
N-(3-acetylphenyl)-1-ethyl-2-oxobenzo[cd]indole-6-sulfonamide
Show/Hide
|
C21H18N2O4S
|
2
|
| 1 |
IC50 = 10 nM
|
|
|
| 2 |
IC50 = 40 nM
|
|
|
|
CP0073544
|
US10301272, Example 6/13
Show/Hide
|
C31H42N4O4S2
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0241642
|
US10301272, Example 19/5
Show/Hide
|
C28H38N4O4S2
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0478350
|
4-cyclohexyl-5-[2,3-dichloro-4-[[(2S)-1,1,1-trifluoropropan-2-yl]sulfamoyl]phenyl]-N-(2-hydroxy-2-methylpropyl)-1,3-thiazole-2-carboxamide
Show/Hide
|
C23H28Cl2F3N3O4S2
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0359931
|
4-[3-[2-chloro-6-(trifluoromethyl)benzoyl]-7-fluoroindol-1-yl]benzoic acid
Show/Hide
|
C23H12ClF4NO3
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0363399
|
4-[3-(2,6-dichlorobenzoyl)indol-1-yl]-3,5-difluorobenzoic acid
Show/Hide
|
C22H11Cl2F2NO3
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0469877
|
[4-chloro-2-(diethylamino)-3-phenylquinolin-6-yl]-(3-methylimidazol-4-yl)-pyridin-4-ylmethanol
Show/Hide
|
C29H28ClN5O
|
1
|
| 1 |
IC50 = 11 nM
|
|
|
|
CP0350236
|
4-[3-(2-chloro-6-methylbenzoyl)-7-fluoroindol-1-yl]benzoic acid
Show/Hide
|
C23H15ClFNO3
|
1
|
| 1 |
IC50 = 11 nM
|
|
|
|
CP0520433
|
4-[3-[2-chloro-6-(trifluoromethyl)benzoyl]-1 H-indol-1-yl]benzoic 4-[3-(2,6-dichlorobenzoyl)-7-fluoro-1H-indol-1-yl]-3-fluoro-benzoic acid
Show/Hide
|
C22H11Cl2F2NO3
|
1
|
| 1 |
IC50 = 11 nM
|
|
|
|
CP0525796
|
US10080744, Example 18
Show/Hide
|
C25H26Cl2F3N3O4S3
|
1
|
| 1 |
IC50 = 11 nM
|
|
|
|
CP0180350
|
US10301272, Example 6/28
Show/Hide
|
C29H36N4O5S2
|
1
|
| 1 |
IC50 = 12 nM
|
|
|
|
CP0517702
|
[4-chloro-2-methoxy-3-[[4-(trifluoromethyl)piperidin-1-yl]methyl]quinolin-6-yl]-(3-methylimidazol-4-yl)-[2-(trifluoromethyl)pyridin-4-yl]methanol
Show/Hide
|
C28H26ClF6N5O2
|
1
|
| 1 |
IC50 = 12 nM
|
|
|
|
CP0557384
|
[4-chloro-2-methoxy-3-[[4-(trifluoromethyl)piperidin-1-yl]methyl]quinolin-6-yl]-(3-methyltriazol-4-yl)-[2-(trifluoromethyl)pyridin-4-yl]methanol
Show/Hide
|
C27H25ClF6N6O2
|
1
|
| 1 |
IC50 = 12 nM
|
|
|
|
CP0326785
|
4-[3-(2,6-dichlorobenzoyl)-7-fluoro-1H-indol-1-yl]benzoic acid
Show/Hide
|
C22H12Cl2FNO3
|
1
|
| 1 |
IC50 = 12 nM
|
|
|
|
CP0341592
|
3-[4-(cyclobutylmethyl)-5-[2-(difluoromethyl)-3-fluoro-4-[[(2S)-1,1,1-trifluorobutan-2-yl]sulfamoyl]phenyl]-1,3-thiazol-2-yl]-2,2-dimethylpropanoic acid
Show/Hide
|
C24H28F6N2O4S2
|
1
|
| 1 |
IC50 = 12.8 nM
|
|
|
|
CP0429951
|
(2,4-dichloro-3-phenylquinolin-6-yl)-(3-methylimidazol-4-yl)-(2-methylpyridin-4-yl)methanol
Show/Hide
|
C26H20Cl2N4O
|
1
|
| 1 |
IC50 = 13 nM
|
|
|
|
CP0341758
|
US10080744, Example 1/1
Show/Hide
|
C29H36N4O4S2
|
1
|
| 1 |
IC50 = 13.5 nM
|
|
|
|
CP0216551
|
CHEMBL4127926
Show/Hide
|
C30H38F3N3O4S
|
1
|
| 1 |
IC50 = 14 nM
|
|
|
|
CP0445110
|
US10201546, Example 136a
Show/Hide
|
C26H28ClN5O2
|
1
|
| 1 |
IC50 = 14 nM
|
|
|
|
CP0557385
|
US10201546, Example 126b
Show/Hide
|
C29H28ClF6N5O2
|
1
|
| 1 |
IC50 = 14 nM
|
|
|
|
CP0387093
|
N-[3-[[(3S)-4-(cyclopentanecarbonyl)-3-methylpiperazin-1-yl]methyl]-5-fluoro-2-methylphenyl]-6-methylpyridine-3-carboxamide
Show/Hide
|
C26H33FN4O2
|
1
|
| 1 |
IC50 = 14 nM
|
|
|
|
CP0341601
|
2,3-dichloro-4-[4-(4-fluoropiperidine-1-carbonyl)-2-[5-(2-hydroxy-2-methylpropyl)-1,3,4-oxadiazol-2-yl]-1,3-thiazol-5-yl]-N-[(2S)-1,1,1-trifluorobutan-2-yl]benzenesulfonamide
Show/Hide
|
C25H27Cl2F4N5O5S2
|
1
|
| 1 |
IC50 = 14 nM
|
|
|
|
CP0363413
|
4-[3-[2-chloro-6-(trifluoromethyl)benzoyl]pyrrolo[2,3-b]pyridin-1-yl]-3-fluorobenzoic acid
Show/Hide
|
C22H11ClF4N2O3
|
1
|
| 1 |
IC50 = 15 nM
|
|
|
|
CP0564300
|
3-[6-[4-(cyclobutylmethyl)-5-[2,3-dichloro-4-[[(2S)-1,1,1-trifluoropropan-2-yl]sulfamoyl]phenyl]-1,3-thiazol-2-yl]pyrimidin-4-yl]-2,2-dimethylpropanoic acid
Show/Hide
|
C26H27Cl2F3N4O4S2
|
1
|
| 1 |
IC50 = 15 nM
|
|
|
|
CP0133587
|
3-[5-[2-chloro-4-[[(2S)-1,1,1-trifluorobutan-2-yl]sulfamoyl]phenyl]-4-(cyclobutylmethyl)-1,3-thiazol-2-yl]-2,2-dimethylpropanoic acid
Show/Hide
|
C23H28ClF3N2O4S2
|
1
|
| 1 |
IC50 = 15.7 nM
|
|
|
|
CP0350577
|
US9303015, 8
Show/Hide
|
C27H26ClN5O2S
|
1
|
| 1 |
IC50 = 16 nM
|
|
|
|
CP0123414
|
3-[[5-[4-(tert-butylsulfamoyl)-2-chlorophenyl]-4-(cyclohexylmethyl)-1,3-thiazole-2-carbonyl]amino]cyclobutane-1-carboxylic acid
Show/Hide
|
C26H34ClN3O5S2
|
1
|
| 1 |
IC50 = 16 nM
|
|
|
|
CP0189869
|
4-[3-[2-chloro-6-(trifluoromethyl)benzoyl]-4-fluoroindol-1-yl]-3-fluorobenzoic acid
Show/Hide
|
C23H11ClF5NO3
|
1
|
| 1 |
IC50 = 16 nM
|
|
|
|
CP0516617
|
3-[5-[4-(cyclobutylmethyl)-5-[2,3-dichloro-4-[[(2S)-1,1,1-trifluoropropan-2-yl]sulfamoyl]phenyl]-1,3-thiazol-2-yl]-1,3,4-thiadiazol-2-yl]-2,2-dimethylpropanoic acid
Show/Hide
|
C24H25Cl2F3N4O4S3
|
1
|
| 1 |
IC50 = 16 nM
|
|
|
|
CP0074081
|
3-[[5-[4-(tert-butylsulfamoyl)-2-(trifluoromethyl)phenyl]-4-(cyclohexylmethyl)-1,3-thiazole-2-carbonyl]amino]cyclobutane-1-carboxylic acid
Show/Hide
|
C27H34F3N3O5S2
|
1
|
| 1 |
IC50 = 17 nM
|
|
|
|
CP0446880
|
5-[2,3-dichloro-4-[[(2S)-1,1,1-trifluoropropan-2-yl]sulfamoyl]phenyl]-4-(3-fluorophenyl)-N-(2-hydroxy-2-methylpropyl)-1,3-thiazole-2-carboxamide
Show/Hide
|
C23H21Cl2F4N3O4S2
|
1
|
| 1 |
IC50 = 17 nM
|
|
|
|
CP0427586
|
4-[1-[2-chloro-6-(trifluoromethyl)benzoyl]-4-fluoroindazol-3-yl]-2-hydroxybenzoic acid
Show/Hide
|
C22H11ClF4N2O4
|
1
|
| 1 |
IC50 = 17 nM
|
|
|
|
CP0458207
|
[4-chloro-2-methoxy-3-[[4-(trifluoromethyl)piperidin-1-yl]methyl]quinolin-6-yl]-(2,3-dimethylimidazol-4-yl)-(3-methyltriazol-4-yl)methanol
Show/Hide
|
C26H29ClF3N7O2
|
1
|
| 1 |
IC50 = 18 nM
|
|
|
|
CP0538154
|
(4-Chloro-3-((4,4-difluoropiperidin-1-yl)methyl)-2-methoxyquinolin-6-yl)(2,6-dimethylpyridin-3-yl)(1-methyl-1H-1,2,3-triazol-5-yl)methanol
Show/Hide
|
C27H29ClF2N6O2
|
1
|
| 1 |
IC50 = 19 nM
|
|
|
|
CP0124348
|
N-(3,4-dimethoxyphenyl)-1-ethyl-2-oxobenzo[cd]indole-6-sulfonamide
Show/Hide
|
C21H20N2O5S
|
2
|
| 1 |
IC50 = 20 nM
|
|
|
| 2 |
IC50 = 50 nM
|
|
|
|
CP0446636
|
US10301272, Example 14/7
Show/Hide
|
C31H39N3O6S2
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0445112
|
US10201546, Example 68a
Show/Hide
|
C25H26ClN5O3
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0242453
|
4-[3-(2,6-dichlorobenzoyl)indol-1-yl]-3-fluorobenzoic acid
Show/Hide
|
C22H12Cl2FNO3
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0326782
|
4-[1-(2,6-dichlorobenzoyl)indazol-3-yl]benzoic acid
Show/Hide
|
C21H12Cl2N2O3
|
2
|
| 1 |
IC50 = 20 nM
|
|
|
| 2 |
IC50 = 400 nM
|
|
|
|
CP0515594
|
US10301272, Example 8/2
Show/Hide
|
C25H31N3O3S2
|
1
|
| 1 |
IC50 = 21 nM
|
|
|
|
CP0469334
|
(2,4-dichloro-3-phenylquinolin-6-yl)-(2-fluoropyridin-4-yl)-(3-methylimidazol-4-yl)methanol
Show/Hide
|
C25H17Cl2FN4O
|
1
|
| 1 |
IC50 = 21 nM
|
|
|
|
CP0575106
|
4-[3-(2-chloro-6-methylbenzoyl)indol-1-yl]-3-fluorobenzoic acid
Show/Hide
|
C23H15ClFNO3
|
1
|
| 1 |
IC50 = 21 nM
|
|
|
|
CP0521151
|
5-[2,3-dichloro-4-[[(2S)-1,1,1-trifluoropropan-2-yl]sulfamoyl]phenyl]-N,N-diethyl-2-[5-(2-hydroxypropan-2-yl)-1,3,4-oxadiazol-2-yl]-1,3-thiazole-4-carboxamide
Show/Hide
|
C22H24Cl2F3N5O5S2
|
1
|
| 1 |
IC50 = 21 nM
|
|
|
|
CP0458063
|
US10201546, Example 103a
Show/Hide
|
C28H30ClF3N6O2
|
1
|
| 1 |
IC50 = 22 nM
|
|
|
|
CP0341598
|
3-[5-[5-[2-(difluoromethyl)-3-fluoro-4-[[(2S)-1,1,1-trifluoropropan-2-yl]sulfamoyl]phenyl]-4-[(3,3-difluoropiperidin-1-yl)methyl]-1,3-thiazol-2-yl]-1,3,4-oxadiazol-2-yl]-2,2-dimethylpropanoic acid
Show/Hide
|
C26H27F8N5O5S2
|
1
|
| 1 |
IC50 = 22 nM
|
|
|
|
CP0341602
|
2,3-dichloro-4-[4-(4,4-difluoropiperidine-1-carbonyl)-2-[5-(2-hydroxypropan-2-yl)-4-methyl-1,2,4-triazol-3-yl]-1,3-thiazol-5-yl]-N-[(2S)-1,1,1-trifluoropropan-2-yl]benzenesulfonamide
Show/Hide
|
C24H25Cl2F5N6O4S2
|
1
|
| 1 |
IC50 = 24 nM
|
|
|
|
CP0429545
|
(4-chloro-2-methoxy-3-phenylquinolin-6-yl)-(3-methylimidazol-4-yl)-pyridin-4-ylmethanol
Show/Hide
|
C26H21ClN4O2
|
1
|
| 1 |
IC50 = 25 nM
|
|
|
|
CP0519392
|
[4-chloro-2-methoxy-3-[[4-(trifluoromethyl)piperidin-1-yl]methyl]quinolin-6-yl]-(2,3-dimethylimidazol-4-yl)-(oxan-4-yl)methanol
Show/Hide
|
C28H34ClF3N4O3
|
1
|
| 1 |
IC50 = 25 nM
|
|
|
|
CP0391038
|
4-[3-(2-chloro-6-methylbenzoyl)indol-1-yl]benzoic acid
Show/Hide
|
C23H16ClNO3
|
1
|
| 1 |
IC50 = 25 nM
|
|
|
|
CP0330311
|
3-[5-[5-[2-(difluoromethyl)-3-fluoro-4-[[(2S)-1,1,1-trifluoropropan-2-yl]sulfamoyl]phenyl]-4-(2-methoxy-2-methylpropyl)-1,3-thiazol-2-yl]-1,3,4-oxadiazol-2-yl]-2,2-dimethylpropanoic acid
Show/Hide
|
C25H28F6N4O6S2
|
1
|
| 1 |
IC50 = 25 nM
|
|
|
|
CP0249438
|
4-[3-(2-chloro-6-methylbenzoyl)pyrrolo[2,3-b]pyridin-1-yl]-3-fluorobenzoic acid
Show/Hide
|
C22H14ClFN2O3
|
1
|
| 1 |
IC50 = 27 nM
|
|
|
|
CP0321519
|
2,3-dichloro-4-[4-(4-fluoropiperidine-1-carbonyl)-2-[5-(2-hydroxypropan-2-yl)-1,2,4-oxadiazol-3-yl]-1,3-thiazol-5-yl]-N-[(2S)-1,1,1-trifluoropropan-2-yl]benzenesulfonamide
Show/Hide
|
C23H23Cl2F4N5O5S2
|
1
|
| 1 |
IC50 = 27 nM
|
|
|
|
CP0538061
|
3-[5-[4-(cyclobutylmethyl)-5-[2,3-dichloro-4-[[(2S)-1,1,1-trifluoropropan-2-yl]sulfamoyl]phenyl]-1,3-thiazol-2-yl]-1,3,4-oxadiazol-2-yl]cyclobutane-1-carboxylic acid
Show/Hide
|
C24H23Cl2F3N4O5S2
|
1
|
| 1 |
IC50 = 27 nM
|
|
|
|
CP0218445
|
US10301272, Example 21/22
Show/Hide
|
C23H28F5N3O4S2
|
1
|
| 1 |
IC50 = 28 nM
|
|
|
|
CP0363398
|
4-[3-(2,6-dichlorobenzoyl)indol-1-yl]benzoic acid
Show/Hide
|
C22H13Cl2NO3
|
1
|
| 1 |
IC50 = 28 nM
|
|
|
|
CP0558076
|
(4-chloro-2-methoxy-3-propan-2-yloxyquinolin-6-yl)-(2,6-dimethylpyridin-3-yl)-(3-methyltriazol-4-yl)methanol
Show/Hide
|
C24H26ClN5O3
|
1
|
| 1 |
IC50 = 29 nM
|
|
|
|
CP0478855
|
4-[3-(2,6-dichlorobenzoyl)indazol-1-yl]benzoic acid
Show/Hide
|
C21H12Cl2N2O3
|
1
|
| 1 |
IC50 = 29 nM
|
|
|
|
CP0484099
|
US10201546, Example 14a
Show/Hide
|
C25H26ClN5O2
|
1
|
| 1 |
IC50 = 30 nM
|
|
|
|
CP0384588
|
2-(4-ethylsulfonylphenyl)-N-[4-[2-fluoro-4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]phenyl]acetamide
Show/Hide
|
C25H20F7NO4S
|
1
|
| 1 |
IC50 = 30 nM
|
|
|
|
CP0359932
|
4-[3-(2,6-dichlorobenzoyl)pyrrolo[2,3-b]pyridin-1-yl]-3-fluorobenzoic acid
Show/Hide
|
C21H11Cl2FN2O3
|
1
|
| 1 |
IC50 = 32 nM
|
|
|
|
CP0389754
|
US10301272, Example 9/6
Show/Hide
|
C31H41N3O4S
|
1
|
| 1 |
IC50 = 33 nM
|
|
|
|
CP0482745
|
US10201546, Example 72a
Show/Hide
|
C25H24ClF2N5O3
|
1
|
| 1 |
IC50 = 33 nM
|
|
|
|
CP0330312
|
2,3-dichloro-4-[4-(4,4-difluoropiperidine-1-carbonyl)-2-[5-(2-hydroxypropan-2-yl)-1,3,4-oxadiazol-2-yl]-1,3-thiazol-5-yl]-N-[(2S)-1,1,1-trifluoropropan-2-yl]benzenesulfonamide
Show/Hide
|
C23H22Cl2F5N5O5S2
|
1
|
| 1 |
IC50 = 33 nM
|
|
|
|
CP0364454
|
4-[1-[2-chloro-6-(trifluoromethyl)benzoyl]-4-fluoroindazol-3-yl]-3-fluorobenzoic acid
Show/Hide
|
C22H10ClF5N2O3
|
1
|
| 1 |
IC50 = 34 nM
|
|
|
|
CP0359933
|
4-[3-(2-chloro-6-methylbenzoyl)-4-fluoroindol-1-yl]-3-fluorobenzoic acid
Show/Hide
|
C23H14ClF2NO3
|
1
|
| 1 |
IC50 = 36 nM
|
|
|
|
CP0303087
|
4-[3-[2-chloro-6-(trifluoromethyl)benzoyl]-7-fluoro-1H-indol-1-yl]benzoic acid (Compound 1)
Show/Hide
|
C23H13ClF3NO3
|
1
|
| 1 |
IC50 = 37 nM
|
|
|
|
CP0359934
|
4-[3-(2,6-dichlorobenzoyl)-4-fluoroindol-1-yl]-3-fluorobenzoic acid
Show/Hide
|
C22H11Cl2F2NO3
|
1
|
| 1 |
IC50 = 37 nM
|
|
|
|
CP0575120
|
4-[3-[2-chloro-6-(trifluoromethyl)benzoyl]-4-fluoroindol-1-yl]benzoic acid
Show/Hide
|
C23H12ClF4NO3
|
1
|
| 1 |
IC50 = 38 nM
|
|
|
|
CP0316508
|
N-(4-acetylphenyl)-1-ethyl-2-oxobenzo[cd]indole-6-sulfonamide
Show/Hide
|
C21H18N2O4S
|
2
|
| 1 |
IC50 = 40 nM
|
|
|
| 2 |
IC50 = 50 nM
|
|
|
|
CP0321859
|
US9290476, 95
Show/Hide
|
C29H22Cl2F3N3O2
|
1
|
| 1 |
IC50 = 41 nM
|
|
|
|
CP0575462
|
[4-chloro-2-methoxy-3-[[3-(trifluoromethyl)azetidin-1-yl]methyl]quinolin-6-yl]-(2,6-dimethylpyridin-3-yl)-(3-methyltriazol-4-yl)methanol
Show/Hide
|
C26H26ClF3N6O2
|
1
|
| 1 |
IC50 = 41 nM
|
|
|
|
CP0537141
|
N-[8-[[(3S)-4-(cyclopentanecarbonyl)-3-methylpiperazin-1-yl]methyl]-7-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl]-6-methylpyridine-3-carboxamide
Show/Hide
|
C26H33N7O2
|
1
|
| 1 |
IC50 = 41 nM
|
|
|
|
CP0218448
|
5-[2,3-dichloro-4-[[(2S)-1,1,1-trifluoropropan-2-yl]sulfamoyl]phenyl]-N-(2-hydroxy-2-methylpropyl)-4-[(2-methylpropan-2-yl)oxymethyl]-1,3-thiazole-2-carboxamide
Show/Hide
|
C22H28Cl2F3N3O5S2
|
1
|
| 1 |
IC50 = 43 nM
|
|
|
|
CP0326784
|
4-[3-[2-chloro-6-(trifluoromethyl)benzoyl]pyrrolo[2,3-b]pyridin-1-yl]benzoic acid
Show/Hide
|
C22H12ClF3N2O3
|
1
|
| 1 |
IC50 = 44 nM
|
|
|
|
CP0438704
|
[4-chloro-2-methoxy-3-(2,2,2-trifluoroethyl)quinolin-6-yl]-(2,6-dimethylpyridin-3-yl)-(3-methyltriazol-4-yl)methanol
Show/Hide
|
C23H21ClF3N5O2
|
1
|
| 1 |
IC50 = 45 nM
|
|
|
|
CP0516619
|
2,3-dichloro-4-[4-(4-fluoropiperidine-1-carbonyl)-2-[5-(2-hydroxypropan-2-yl)-1,3,4-oxadiazol-2-yl]-1,3-thiazol-5-yl]-N-[(2S)-1,1,1-trifluoropropan-2-yl]benzenesulfonamide
Show/Hide
|
C23H23Cl2F4N5O5S2
|
1
|
| 1 |
IC50 = 45 nM
|
|
|
|
CP0133588
|
3-[4-(cyclobutylmethyl)-5-[2-(trifluoromethyl)-4-[[(2S)-1,1,1-trifluoropropan-2-yl]sulfamoyl]phenyl]-1,3-thiazol-2-yl]-2,2-dimethylpropanoic acid
Show/Hide
|
C23H26F6N2O4S2
|
1
|
| 1 |
IC50 = 47 nM
|
|
|
|
CP0078472
|
N-[3,5-dichloro-4-[2-(trifluoromethoxy)phenyl]phenyl]-2-(4-methylsulfonylphenyl)acetamide
Show/Hide
|
C22H16Cl2F3NO4S
|
1
|
| 1 |
IC50 = 47 nM
|
|
|
|
CP0353858
|
US10301272, Example 6/49
Show/Hide
|
C31H39N3O5S2
|
1
|
| 1 |
IC50 = 48 nM
|
|
|
|
CP0557381
|
(3S,4R)-1-(1-(2-chloro-6-cyclopropylbenzoyl)-4-fluoro-1H-indazol-3-yl)-3-hydroxypiperidine-4-carboxylic acid
Show/Hide
|
C23H21ClFN3O4
|
1
|
| 1 |
IC50 = 49 nM
|
|
|
|
CP0429571
|
(2,4-dichloro-3-phenylquinolin-6-yl)-(3-methylimidazol-4-yl)-pyridin-4-ylmethanol
Show/Hide
|
C25H18Cl2N4O
|
1
|
| 1 |
IC50 = 50 nM
|
|
|
|
CP0469881
|
[2-(azetidin-1-yl)-4-chloro-3-phenylquinolin-6-yl]-(3-methylimidazol-4-yl)-[6-(trifluoromethyl)pyridin-3-yl]methanol
Show/Hide
|
C29H23ClF3N5O
|
1
|
| 1 |
IC50 = 50 nM
|
|
|
|
CP0519393
|
1-[3-[[4-chloro-2-methoxy-3-[[4-(trifluoromethyl)piperidin-1-yl]methyl]quinolin-6-yl]-hydroxy-[6-(trifluoromethyl)pyridin-3-yl]methyl]azetidin-1-yl]ethanone
Show/Hide
|
C29H29ClF6N4O3
|
1
|
| 1 |
IC50 = 50 nM
|
|
|
|
CP0520131
|
6-methyl-N-[7-methyl-8-[[(3S)-3-methyl-4-[4,4,4-trifluoro-3-(trifluoromethyl)butanoyl]piperazin-1-yl]methyl]-[1,2,4]triazolo[1,5-a]pyridin-6-yl]pyridine-3-carboxamide
Show/Hide
|
C25H27F6N7O2
|
1
|
| 1 |
IC50 = 50 nM
|
|
|
|
CP0557954
|
6-methyl-N-[7-methyl-8-[(2S,4S)-2-methyl-1-[4,4,4-trifluoro-3-(trifluoromethyl)butanoyl]piperidin-4-yl]oxy-[1,2,4]triazolo[1,5-a]pyridin-6-yl]pyridine-3-carboxamide
Show/Hide
|
C25H26F6N6O3
|
1
|
| 1 |
IC50 = 51 nM
|
|
|
|
CP0073546
|
US10301272, Example 7/3
Show/Hide
|
C30H40N2O3S
|
1
|
| 1 |
IC50 = 52 nM
|
|
|
|
CP0420690
|
(3S,4R)-1-(1-(2- chloro-6- (trifluoromethyl)benzoyl)- 4-fluoro-1H-indazol-3-yl)- 3-hydroxypiperidine-4- carboxylic acid
Show/Hide
|
C21H16ClF4N3O4
|
1
|
| 1 |
IC50 = 53 nM
|
|
|
|
CP0546354
|
1-[3-[[4-(cyclopentanecarbonyl)piperazin-1-yl]methyl]-2-methylphenyl]-3-phenylthiourea
Show/Hide
|
C25H32N4OS
|
1
|
| 1 |
IC50 = 57 nM
|
|
|
|
CP0533384
|
6-methyl-N-[7-methyl-8-[[(3S)-3-methyl-4-(3-methylbutanoyl)piperazin-1-yl]methyl]-[1,2,4]triazolo[1,5-a]pyridin-6-yl]pyridine-3-carboxamide
Show/Hide
|
C25H33N7O2
|
1
|
| 1 |
IC50 = 59 nM
|
|
|
|
CP0531959
|
US10201546, Example 112c
Show/Hide
|
C28H26ClF6N5O2
|
1
|
| 1 |
IC50 = 61 nM
|
|
|
|
CP0359930
|
4-[7-chloro-3-(2,6-dichlorobenzoyl)indol-1-yl]benzoic acid
Show/Hide
|
C22H12Cl3NO3
|
1
|
| 1 |
IC50 = 70 nM
|
|
|
|
CP0254684
|
US9303015, 7
Show/Hide
|
C31H27Cl2N3O2
|
1
|
| 1 |
IC50 = 72 nM
|
|
|
|
CP0427584
|
4-[1-[2-chloro-6-(trifluoromethyl)benzoyl]-4-fluoroindazol-3-yl]benzoic acid
Show/Hide
|
C22H11ClF4N2O3
|
1
|
| 1 |
IC50 = 72 nM
|
|
|
|
CP0227144
|
US9290476, 33A
Show/Hide
|
C31H25Cl2N5O2
|
1
|
| 1 |
IC50 = 73 nM
|
|
|
|
CP0570528
|
4-[3-(2,6-dichlorobenzoyl)indol-1-yl]-2,3-difluorobenzoic acid
Show/Hide
|
C22H11Cl2F2NO3
|
1
|
| 1 |
IC50 = 75 nM
|
|
|
|
CP0120332
|
3-(1,3-benzodioxol-5-yl)-1-(3,5-dimethylpiperidin-1-yl)-3-(2-hydroxy-4,6-dimethoxyphenyl)propan-1-one
Show/Hide
|
C25H31NO6
|
1
|
| 1 |
IC50 = 76 nM
|
|
|
|
CP0356460
|
4-[3-(2,6-dichlorobenzoyl)-4-fluoroindol-1-yl]benzoic acid
Show/Hide
|
C22H12Cl2FNO3
|
1
|
| 1 |
IC50 = 76 nM
|
|
|
|
CP0575547
|
1-[3-[[4-(cyclopentanecarbonyl)piperazin-1-yl]methyl]-2-methylphenyl]-3-phenylurea
Show/Hide
|
C25H32N4O2
|
1
|
| 1 |
IC50 = 77 nM
|
|
|
|
CP0438719
|
N-[8-[[(3S)-4-benzoyl-3-methylpiperazin-1-yl]methyl]-7-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl]-6-methylpyridine-3-carboxamide
Show/Hide
|
C27H29N7O2
|
1
|
| 1 |
IC50 = 79 nM
|
|
|
|
CP0209305
|
N-(1-ethyl-2-oxobenzo[cd]indol-6-yl)sulfonyl-N-(4-methoxyphenyl)pyridine-4-carboxamide
Show/Hide
|
C26H21N3O5S
|
2
|
| 1 |
IC50 = 80 nM
|
|
|
| 2 |
IC50 = 90 nM
|
|
|
|
CP0404195
|
(2,4-dichloro-3-phenylquinolin-6-yl)-(3-methylimidazol-4-yl)-[2-(trifluoromethyl)pyridin-4-yl]methanol
Show/Hide
|
C26H17Cl2F3N4O
|
1
|
| 1 |
IC50 = 82 nM
|
|
|
|
CP0579656
|
1-[4-[5-chloro-3-[[(4R)-4-hydroxy-4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl]amino]-2-methylphenoxy]piperidin-1-yl]-4,4,4-trifluoro-3-(trifluoromethyl)butan-1-one
Show/Hide
|
C24H26ClF6N3O3S
|
1
|
| 1 |
IC50 = 83 nM
|
|
|
|
CP0347123
|
US9303015, 36
Show/Hide
|
C30H25Cl2N3O2
|
1
|
| 1 |
IC50 = 89 nM
|
|
|
|
CP0097925
|
US9290476, 35A
Show/Hide
|
C31H24ClF3N6O2
|
1
|
| 1 |
IC50 = 89 nM
|
|
|
|
CP0124347
|
N-[4-[(1-ethyl-2-oxobenzo[cd]indol-6-yl)sulfonylamino]phenyl]acetamide
Show/Hide
|
C21H19N3O4S
|
2
|
| 1 |
IC50 = 90 nM
|
|
|
| 2 |
IC50 = 320 nM
|
|
|
|
CP0382285
|
N-(1-acetylpiperidin-4-yl)-1-ethyl-2-oxobenzo[cd]indole-6-sulfonamide
Show/Hide
|
C20H23N3O4S
|
2
|
| 1 |
IC50 = 90 nM
|
|
|
| 2 |
IC50 = 270 nM
|
|
|
|
CP0543816
|
4-[1-[2-chloro-6-(trifluoromethyl)benzoyl]pyrazolo[4,3-b]pyridin-3-yl]-3-fluorobenzoic acid
Show/Hide
|
C21H10ClF4N3O3
|
1
|
| 1 |
IC50 = 90 nM
|
|
|
|
CP0552969
|
methyl 4-[[4-[2-fluoro-4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]phenyl]sulfamoylmethyl]benzoate
Show/Hide
|
C24H18F7NO5S
|
1
|
| 1 |
IC50 = 90 nM
|
|
|
|
CP0262521
|
4-[3-(2-chloro-6-methylbenzoyl)-4-fluoroindol-1-yl]benzoic acid
Show/Hide
|
C23H15ClFNO3
|
1
|
| 1 |
IC50 = 93 nM
|
|
|
|
CP0578383
|
1-[4-[5-chloro-3-[[(4S)-4-hydroxy-4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl]amino]-2-methylphenoxy]piperidin-1-yl]-4,4,4-trifluoro-3-(trifluoromethyl)butan-1-one
Show/Hide
|
C24H26ClF6N3O3S
|
1
|
| 1 |
IC50 = 98 nM
|
|
|
|
CP0145239
|
4-[1-[2-chloro-6-(trifluoromethyl)benzoyl]pyrazolo[3,4-c]pyridin-3-yl]-3-fluorobenzoic acid
Show/Hide
|
C21H10ClF4N3O3
|
1
|
| 1 |
IC50 = 99 nM
|
|
|
|
CP0341215
|
1-ethyl-N-isoquinolin-8-yl-2-oxobenzo[cd]indole-6-sulfonamide
Show/Hide
|
C22H17N3O3S
|
2
|
| 1 |
IC50 = 100 nM
|
|
|
| 2 |
IC50 = 150 nM
|
|
|
|
CP0350545
|
US9303015, 35
Show/Hide
|
C28H20Cl3N3O
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0467654
|
(2,4-dichloro-3-phenylquinolin-6-yl)-(2,4-dimethyl-1,3-thiazol-5-yl)-(3-methylimidazol-4-yl)methanol
Show/Hide
|
C25H20Cl2N4OS
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0572202
|
cyclopentyl-[4-[[3-(6,7-dihydro-4H-pyrano[4,3-d][1,3]thiazol-2-ylamino)-2-methylphenyl]methyl]piperazin-1-yl]methanone
Show/Hide
|
C24H32N4O2S
|
1
|
| 1 |
IC50 = 101 nM
|
|
|
|
CP0075606
|
4-[3-(2,6-dichlorobenzoyl)pyrrolo[2,3-b]pyridin-1-yl]benzoic acid
Show/Hide
|
C21H12Cl2N2O3
|
1
|
| 1 |
IC50 = 104 nM
|
|
|
|
CP0545693
|
US9487490, 1C
Show/Hide
|
C22H15ClF4N2O3
|
1
|
| 1 |
IC50 = 107 nM
|
|
|
|
CP0363400
|
4-[3-(2,4,6-trichlorobenzoyl)indol-1-yl]benzoic acid
Show/Hide
|
C22H12Cl3NO3
|
1
|
| 1 |
IC50 = 107 nM
|
|
|
|
CP0095581
|
1,1,1,3,3,3-hexafluoro-2-[3-fluoro-4-[4-[[4-(pyridin-4-ylmethyl)piperazin-1-yl]methyl]phenyl]phenyl]propan-2-ol
Show/Hide
|
C26H24F7N3O
|
4
|
| 1 |
IC50 = 110 nM
|
|
|
| 2 |
IC50 = 320 nM
|
|
|
| 3 |
IC50 = 420 nM
|
|
|
| 4 |
IC50 = 430 nM
|
|
|
|
CP0328262
|
US9303015, 20
Show/Hide
|
C28H18ClN5O2
|
1
|
| 1 |
IC50 = 110 nM
|
|
|
|
CP0418153
|
US9303015, 28
Show/Hide
|
C31H29ClF3N5O3
|
1
|
| 1 |
IC50 = 110 nM
|
|
|
|
CP0412830
|
[2-chloro-4-(dimethylamino)-3-phenylquinolin-6-yl]-(3-methylimidazol-4-yl)-pyridin-4-ylmethanol
Show/Hide
|
C27H24ClN5O
|
1
|
| 1 |
IC50 = 110 nM
|
|
|
|
CP0475984
|
4-chloro-6-[(4-chlorophenyl)-hydroxy-(3-methylimidazol-4-yl)methyl]-3-phenylquinoline-2-carbonitrile
Show/Hide
|
C27H18Cl2N4O
|
1
|
| 1 |
IC50 = 110 nM
|
|
|
|
CP0510320
|
(4-chlorophenyl)-(3-methylimidazol-4-yl)-[3-phenyl-2,4-bis(trifluoromethyl)quinolin-6-yl]methanol
Show/Hide
|
C28H18ClF6N3O
|
1
|
| 1 |
IC50 = 110 nM
|
|
|
|
CP0549977
|
1-[4-[5-chloro-3-[(4-hydroxy-4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl)amino]-2-methylphenoxy]piperidin-1-yl]-4,4,4-trifluoro-3-(trifluoromethyl)butan-1-one
Show/Hide
|
C24H26ClF6N3O3S
|
1
|
| 1 |
IC50 = 110 nM
|
|
|
|
CP0141520
|
N-[3,5-dichloro-4-[2-(trifluoromethoxy)phenyl]phenyl]-2-(4-ethylsulfonylphenyl)acetamide
Show/Hide
|
C23H18Cl2F3NO4S
|
1
|
| 1 |
IC50 = 112 nM
|
|
|
|
CP0120333
|
1-(3,5-dimethylpiperidin-1-yl)-3-(2-hydroxy-4,6-dimethoxyphenyl)-3-(4-methoxyphenyl)propan-1-one
Show/Hide
|
C25H33NO5
|
1
|
| 1 |
IC50 = 114 nM
|
|
|
|
CP0484100
|
[4-chloro-2-methoxy-3-[[4-(trifluoromethyl)piperidin-1-yl]methyl]quinolin-6-yl]-bis(2,3-dimethylimidazol-4-yl)methanol
Show/Hide
|
C28H32ClF3N6O2
|
2
|
| 1 |
IC50 = 116 nM
|
|
|
| 2 |
IC50 = 121 nM
|
|
|
|
CP0189867
|
4-[3-(2-chlorobenzoyl)-7-methylindol-1-yl]-3-fluorobenzoic acid
Show/Hide
|
C23H15ClFNO3
|
1
|
| 1 |
IC50 = 119 nM
|
|
|
|
CP0312499
|
US9290476, 62A
Show/Hide
|
C29H21ClF6N4O2
|
1
|
| 1 |
IC50 = 120 nM
|
|
|
|
CP0469878
|
(4-chlorophenyl)-[4-chloro-3-phenyl-2-(trifluoromethyl)quinolin-6-yl]-(3-methylimidazol-4-yl)methanol
Show/Hide
|
C27H18Cl2F3N3O
|
1
|
| 1 |
IC50 = 120 nM
|
|
|
|
CP0412979
|
N-[4-[2-fluoro-4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]phenyl]-2-(4-methylsulfonylphenyl)acetamide
Show/Hide
|
C24H18F7NO4S
|
1
|
| 1 |
IC50 = 120 nM
|
|
|
|
CP0482746
|
[4-chloro-2-methoxy-3-[(4-pyrazol-1-ylpiperidin-1-yl)methyl]quinolin-6-yl]-(2,6-dimethylpyridin-3-yl)-(3-methyltriazol-4-yl)methanol
Show/Hide
|
C30H33ClN8O2
|
1
|
| 1 |
IC50 = 122 nM
|
|
|
|
CP0575102
|
3-chloro-4-[3-(2,6-dichlorobenzoyl)indol-1-yl]benzoic acid
Show/Hide
|
C22H12Cl3NO3
|
1
|
| 1 |
IC50 = 124 nM
|
|
|
|
CP0129308
|
4-[1-[2-chloro-6-(trifluoromethyl)benzoyl]indazol-3-yl]benzoic acid
Show/Hide
|
C22H12ClF3N2O3
|
1
|
| 1 |
IC50 = 127 nM
|
|
|
|
CP0040077
|
(3beta)-3-hydroxyurs-12-en-28-oic acid
Show/Hide
|
C30H48O3
|
2
|
| 1 |
IC50 = 130 nM
|
|
|
| 2 |
IC50 = 1060 nM
|
|
|
|
CP0316509
|
N-[(2,5-dichlorophenyl)methyl]-1-ethyl-2-oxobenzo[cd]indole-6-sulfonamide
Show/Hide
|
C20H16Cl2N2O3S
|
2
|
| 1 |
IC50 = 130 nM
|
|
|
| 2 |
IC50 = 1080 nM
|
|
|
|
CP0541320
|
(2,4-dichloro-3-phenylquinolin-6-yl)-phenyl-pyridin-3-ylmethanol
Show/Hide
|
C27H18Cl2N2O
|
1
|
| 1 |
IC50 = 130 nM
|
|
|
|
CP0551212
|
N-[8-[[(3S)-4-(3,3-difluorocyclopentanecarbonyl)-3-methylpiperazin-1-yl]methyl]-7-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl]-6-methylpyridine-3-carboxamide
Show/Hide
|
C26H31F2N7O2
|
1
|
| 1 |
IC50 = 130 nM
|
|
|
|
CP0455816
|
4-[1-[2-chloro-6-(trifluoromethyl)benzoyl]-4-fluoroindazol-3-yl]-2-fluorobenzoic acid
Show/Hide
|
C22H10ClF5N2O3
|
1
|
| 1 |
IC50 = 131 nM
|
|
|
|
CP0208514
|
2-oxo-N-(4-phenoxyphenyl)-1H-benzo[cd]indole-6-sulfonamide
Show/Hide
|
C23H16N2O4S
|
2
|
| 1 |
IC50 = 140 nM
|
|
|
| 2 |
IC50 = 150 nM
|
|
|
|
CP0403336
|
US9290476, 63A
Show/Hide
|
C29H22Cl2N4O2
|
1
|
| 1 |
IC50 = 140 nM
|
|
|
|
CP0471704
|
(2,4-dichloro-3-phenylquinolin-6-yl)-(3-methylimidazol-4-yl)-pyridin-3-ylmethanol
Show/Hide
|
C25H18Cl2N4O
|
1
|
| 1 |
IC50 = 140 nM
|
|
|
|
CP0566280
|
US9303015, 17
Show/Hide
|
C28H26ClN5O3
|
1
|
| 1 |
IC50 = 150 nM
|
|
|
|
CP0346995
|
US9346782, 1
Show/Hide
|
C24H22Cl2N2O2
|
1
|
| 1 |
IC50 = 150 nM
|
|
|
|
CP0551961
|
2-(4-ethylsulfonylphenyl)-N-[4-[2-[7-(2-methylpropyl)-3,4-dihydro-2H-quinolin-1-yl]-2-oxoethyl]phenyl]acetamide
Show/Hide
|
C31H36N2O4S
|
1
|
| 1 |
IC50 = 151 nM
|
|
|
|
CP0576122
|
1-[3-[[4-chloro-2-methoxy-3-[[4-(trifluoromethyl)piperidin-1-yl]methyl]quinolin-6-yl]-hydroxy-(3-methyltriazol-4-yl)methyl]azetidin-1-yl]ethanone
Show/Hide
|
C26H30ClF3N6O3
|
1
|
| 1 |
IC50 = 166 nM
|
|
|
|
CP0129452
|
US9303015, 39
Show/Hide
|
C29H22Cl3N3O
|
1
|
| 1 |
IC50 = 170 nM
|
|
|
|
CP0427588
|
4-[1-[2-chloro-6-(trifluoromethyl)benzoyl]pyrazolo[4,3-d]pyrimidin-3-yl]-3-fluorobenzoic acid
Show/Hide
|
C20H9ClF4N4O3
|
1
|
| 1 |
IC50 = 177 nM
|
|
|
|
CP0218474
|
N-(4-methoxyphenyl)-4-[(2-oxo-1H-benzo[cd]indol-6-yl)sulfonylamino]benzamide
Show/Hide
|
C25H19N3O5S
|
2
|
| 1 |
IC50 = 180 nM
|
|
|
| 2 |
IC50 = 380 nM
|
|
|
|
CP0459083
|
(2,4-dichloro-3-phenylquinolin-6-yl)-(3-methylimidazol-4-yl)-[6-(trifluoromethyl)pyridin-3-yl]methanol
Show/Hide
|
C26H17Cl2F3N4O
|
1
|
| 1 |
IC50 = 180 nM
|
|
|
|
CP0551516
|
cyclopentyl-[4-[[3-[(7-hydroxy-4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl)amino]-2-methylphenyl]methyl]piperazin-1-yl]methanone
Show/Hide
|
C25H34N4O2S
|
1
|
| 1 |
IC50 = 181 nM
|
|
|
|
CP0455818
|
4-[1-[2-chloro-6-(trifluoromethyl)benzoyl]pyrrolo[3,2-b]pyridin-3-yl]-3-fluorobenzoic acid
Show/Hide
|
C22H11ClF4N2O3
|
1
|
| 1 |
IC50 = 187 nM
|
|
|
|
CP0412832
|
[4-methoxy-3-phenyl-2-(trifluoromethyl)quinolin-6-yl]-(3-methylimidazol-4-yl)-[6-(trifluoromethyl)pyridin-3-yl]methanol
Show/Hide
|
C28H20F6N4O2
|
1
|
| 1 |
IC50 = 190 nM
|
|
|
|
CP0455817
|
3-chloro-4-[1-[2-chloro-6-(trifluoromethyl)benzoyl]-4-fluoroindazol-3-yl]benzoic acid
Show/Hide
|
C22H10Cl2F4N2O3
|
1
|
| 1 |
IC50 = 190 nM
|
|
|
|
CP0548489
|
N-[4-[2-fluoro-4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]phenyl]-2-(2-nitrophenyl)acetamide
Show/Hide
|
C23H15F7N2O4
|
1
|
| 1 |
IC50 = 190 nM
|
|
|
|
CP0537130
|
US10201546, Example 69a
Show/Hide
|
C26H28ClN5O4
|
1
|
| 1 |
IC50 = 193 nM
|
|
|
|
CP0262519
|
4-[3-(2,6-dichlorobenzoyl)-6-fluoroindol-1-yl]benzoic acid
Show/Hide
|
C22H12Cl2FNO3
|
1
|
| 1 |
IC50 = 199 nM
|
|
|
|
CP0359929
|
4-[3-(2-chloro-6-fluorobenzoyl)indol-1-yl]benzoic acid
Show/Hide
|
C22H13ClFNO3
|
1
|
| 1 |
IC50 = 199 nM
|
|
|
|
CP0218473
|
1-ethyl-2-oxo-N-(4-phenyldiazenylphenyl)benzo[cd]indole-6-sulfonamide
Show/Hide
|
C25H20N4O3S
|
1
|
| 1 |
IC50 = 200 nM
|
|
|
|
CP0539793
|
[4-chloro-2-methoxy-3-[(4-pyrazol-1-ylphenyl)methyl]quinolin-6-yl]-bis(2,3-dimethylimidazol-4-yl)methanol
Show/Hide
|
C31H30ClN7O2
|
1
|
| 1 |
IC50 = 200 nM
|
|
|
|
CP0575104
|
4-[3-(2-chlorobenzoyl)indol-1-yl]benzoic acid
Show/Hide
|
C22H14ClNO3
|
1
|
| 1 |
IC50 = 205 nM
|
|
|
|
CP0456383
|
3-[[5-[3-(1-cyanocyclopropyl)-5-[[(2S)-1,1,1-trifluoropropan-2-yl]carbamoyl]phenyl]-4-(cyclohexylmethyl)-1,3-thiazole-2-carbonyl]amino]cyclobutane-1-carboxylic acid
Show/Hide
|
C30H33F3N4O4S
|
1
|
| 1 |
IC50 = 209 nM
|
|
|
|
CP0473655
|
[4-chloro-2-methoxy-3-[(4-pyrazol-1-ylphenyl)methyl]quinolin-6-yl]-(4-chlorophenyl)-(3-methylimidazol-4-yl)methanamine
Show/Hide
|
C31H26Cl2N6O
|
1
|
| 1 |
IC50 = 210 nM
|
|
|
|
CP0508251
|
4-[3-(2-chloro-4,6-difluorobenzoyl)indol-1-yl]benzoic acid
Show/Hide
|
C22H12ClF2NO3
|
1
|
| 1 |
IC50 = 210 nM
|
|
|
|
CP0356451
|
4-[3-(2,6-dichlorobenzoyl)indol-1-yl]-3-methylbenzoic acid
Show/Hide
|
C23H15Cl2NO3
|
1
|
| 1 |
IC50 = 213 nM
|
|
|
|
CP0393654
|
(4-chloro-2-methoxy-3-phenylquinolin-6-yl)-(4-chlorophenyl)-(3-methylimidazol-4-yl)methanol
Show/Hide
|
C27H21Cl2N3O2
|
1
|
| 1 |
IC50 = 220 nM
|
|
|
|
CP0519084
|
6-methyl-N-[7-methyl-8-[[(3S)-3-methyl-4-(2-methylpropanoyl)piperazin-1-yl]methyl]-[1,2,4]triazolo[1,5-a]pyridin-6-yl]pyridine-3-carboxamide
Show/Hide
|
C24H31N7O2
|
1
|
| 1 |
IC50 = 230 nM
|
|
|
|
CP0484956
|
6-[(4-chlorophenyl)-hydroxy-(3-methylimidazol-4-yl)methyl]-3-phenylquinoline-2,4-dicarbonitrile
Show/Hide
|
C28H18ClN5O
|
1
|
| 1 |
IC50 = 240 nM
|
|
|
|
CP0471751
|
6-methyl-N-[7-methyl-8-[[(3S)-3-methyl-4-(4,4,4-trifluorobutanoyl)piperazin-1-yl]methyl]-[1,2,4]triazolo[1,5-a]pyridin-6-yl]pyridine-3-carboxamide
Show/Hide
|
C24H28F3N7O2
|
1
|
| 1 |
IC50 = 240 nM
|
|
|
|
CP0546008
|
US9303015, 34
Show/Hide
|
C30H27ClF3N5O3
|
1
|
| 1 |
IC50 = 250 nM
|
|
|
|
CP0546351
|
2-[3-[[4-(cyclopentanecarbonyl)piperazin-1-yl]methyl]-2-methylanilino]-5,6-dihydro-4H-1,3-benzothiazol-7-one
Show/Hide
|
C25H32N4O2S
|
1
|
| 1 |
IC50 = 250 nM
|
|
|
|
CP0328767
|
4-[3-(2,6-dichlorobenzoyl)-5-fluoroindol-1-yl]benzoic acid
Show/Hide
|
C22H12Cl2FNO3
|
1
|
| 1 |
IC50 = 251 nM
|
|
|
|
CP0429940
|
(4-chlorophenyl)-(2,4-dichloro-3-phenylquinolin-6-yl)-(3-methylimidazol-4-yl)methanol
Show/Hide
|
C26H18Cl3N3O
|
1
|
| 1 |
IC50 = 260 nM
|
|
|
|
CP0156196
|
1-(3,5-dimethylpiperidin-1-yl)-3-(2-hydroxy-4,6-dimethoxyphenyl)-3-(2-methoxyphenyl)propan-1-one
Show/Hide
|
C25H33NO5
|
1
|
| 1 |
IC50 = 265 nM
|
|
|
|
CP0576575
|
1-[4-[5-chloro-2-methyl-3-(4,5,6,7-tetrahydro-1,3-benzothiazol-2-ylamino)phenoxy]piperidin-1-yl]-4,4,4-trifluoro-3-(trifluoromethyl)butan-1-one
Show/Hide
|
C24H26ClF6N3O2S
|
1
|
| 1 |
IC50 = 269 nM
|
|
|
|
CP0556179
|
US9303015, 33
Show/Hide
|
C31H24ClF3N6O2
|
1
|
| 1 |
IC50 = 280 nM
|
|
|
|
CP0570416
|
[4-chloro-3-[(1,1-dioxothian-4-yl)methyl]-2-methoxyquinolin-6-yl]-(2,6-dimethylpyridin-3-yl)-(3-methyltriazol-4-yl)methanol
Show/Hide
|
C27H30ClN5O4S
|
1
|
| 1 |
IC50 = 280 nM
|
|
|
|
CP0385753
|
1-ethyl-N-(2-morpholin-4-ylethyl)-2-oxobenzo[cd]indole-6-sulfonamide
Show/Hide
|
C19H23N3O4S
|
2
|
| 1 |
IC50 = 290 nM
|
|
|
| 2 |
IC50 = 350 nM
|
|
|
|
CP0326783
|
4-[3-(2,6-dichlorobenzoyl)indol-1-yl]-2-fluorobenzoic acid
Show/Hide
|
C22H12Cl2FNO3
|
1
|
| 1 |
IC50 = 290 nM
|
|
|
|
CP0304423
|
3-(1,3-benzodioxol-5-yl)-1-[(3S,5R)-3,5-dimethylpiperidin-1-yl]-3-(2-hydroxy-4,6-dimethoxyphenyl)propan-1-one
Show/Hide
|
C25H31NO6
|
1
|
| 1 |
IC50 = 300 nM
|
|
|
|
CP0159378
|
N-(4-morpholin-4-ylphenyl)-2-oxo-1H-benzo[cd]indole-6-sulfonamide
Show/Hide
|
C21H19N3O4S
|
2
|
| 1 |
IC50 = 300 nM
|
|
|
| 2 |
IC50 = 410 nM
|
|
|
|
CP0569930
|
1-(1-(2-chloro-6- (trifluoromethyl)benzoyl)-4-fluoro-1H- indazol-3- yl)piperidine-4- carboxylic acid
Show/Hide
|
C21H16ClF4N3O3
|
1
|
| 1 |
IC50 = 300 nM
|
|
|
|
CP0510306
|
5-[4-chloro-6-[hydroxy-(3-methylimidazol-4-yl)-[6-(trifluoromethyl)pyridin-3-yl]methyl]-2-methoxyquinolin-3-yl]pyrimidine-2-carbonitrile
Show/Hide
|
C26H17ClF3N7O2
|
1
|
| 1 |
IC50 = 310 nM
|
|
|
|
CP0489668
|
1-[3-[[4-chloro-2-methoxy-3-[[4-(trifluoromethyl)piperidin-1-yl]methyl]quinolin-6-yl]-(2,3-dimethylimidazol-4-yl)-hydroxymethyl]azetidin-1-yl]ethanone
Show/Hide
|
C28H33ClF3N5O3
|
1
|
| 1 |
IC50 = 313 nM
|
|
|
|
CP0431679
|
US10201546, Example 12a
Show/Hide
|
C22H22ClN5O2
|
1
|
| 1 |
IC50 = 327 nM
|
|
|
|
CP0003740
|
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(2,2,2-trifluoroethyl)benzenesulfonamide
Show/Hide
|
C17H12F9NO3S
|
5
|
| 1 |
IC50 = 330 nM
|
|
|
| 2 |
IC50 = 540 nM
|
|
|
| 3 |
IC50 = 810 nM
|
|
|
| 4 |
IC50 = 1700 nM
|
|
|
| 5 |
IC50 = 3500 nM
|
|
|
|
CP0316507
|
1-ethyl-N-(4-morpholin-4-ylphenyl)-2-oxobenzo[cd]indole-6-sulfonamide
Show/Hide
|
C23H23N3O4S
|
2
|
| 1 |
IC50 = 340 nM
|
|
|
| 2 |
IC50 = 550 nM
|
|
|
|
CP0531094
|
US9303015, 16
Show/Hide
|
C28H24Cl2N4O2
|
1
|
| 1 |
IC50 = 360 nM
|
|
|
|
CP0560184
|
US9303015, 26
Show/Hide
|
C31H27Cl2F3N4O2
|
1
|
| 1 |
IC50 = 360 nM
|
|
|
|
CP0538306
|
US10201546, Example 83
Show/Hide
|
C28H28ClF3N6O3
|
1
|
| 1 |
IC50 = 386 nM
|
|
|
|
CP0551348
|
4-[1-(2-chloro-6-propan-2-yloxybenzoyl)indazol-3-yl]benzoic acid
Show/Hide
|
C24H19ClN2O4
|
1
|
| 1 |
IC50 = 393 nM
|
|
|
|
CP0382343
|
1-ethyl-N-[[4-methyl-6-(trifluoromethyl)pyrimidin-2-yl]methyl]-2-oxobenzo[cd]indole-6-sulfonamide
Show/Hide
|
C20H17F3N4O3S
|
2
|
| 1 |
IC50 = 410 nM
|
|
|
| 2 |
IC50 = 2570 nM
|
|
|
|
CP0531095
|
US9303015, 19
Show/Hide
|
C27H18Cl2N4O2
|
1
|
| 1 |
IC50 = 410 nM
|
|
|
|
CP0549964
|
cyclopentyl-[4-[[3-[[(4E)-4-hydroxyimino-6,7-dihydro-5H-1,3-benzothiazol-2-yl]amino]-2-methylphenyl]methyl]piperazin-1-yl]methanone
Show/Hide
|
C25H33N5O2S
|
1
|
| 1 |
IC50 = 419 nM
|
|
|
|
CP0483186
|
4-[[2-[N-(4-methylphenyl)sulfonyl-3-(trifluoromethyl)anilino]acetyl]amino]benzamide
Show/Hide
|
C23H20F3N3O4S
|
1
|
| 1 |
IC50 = 420 nM
|
|
|
|
CP0328766
|
4-[3-(2,6-difluorobenzoyl)indol-1-yl]benzoic acid
Show/Hide
|
C22H13F2NO3
|
1
|
| 1 |
IC50 = 445 nM
|
|
|
|
CP0557460
|
US9346782, 2
Show/Hide
|
C22H18Cl2N2O2
|
1
|
| 1 |
IC50 = 450 nM
|
|
|
|
CP0570068
|
methyl 4-[4-[2-fluoro-4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]anilino]-4-oxobutanoate
Show/Hide
|
C20H16F7NO4
|
1
|
| 1 |
IC50 = 460 nM
|
|
|
|
CP0216651
|
US9303015, 29
Show/Hide
|
C31H28ClF3N4O2
|
1
|
| 1 |
IC50 = 470 nM
|
|
|
|
CP0136991
|
US9303015, 40
Show/Hide
|
C28H23Cl3N4O
|
1
|
| 1 |
IC50 = 490 nM
|
|
|
|
CP0283197
|
US9346782, 15
Show/Hide
|
C24H22Cl2N2OS
|
1
|
| 1 |
IC50 = 500 nM
|
|
|
|
CP0324331
|
US9346782, 17
Show/Hide
|
C29H32ClF3N2O4
|
1
|
| 1 |
IC50 = 500 nM
|
|
|
|
CP0350234
|
3,5-dichloro-4-[3-(2,6-dichlorobenzoyl)indol-1-yl]benzoic acid
Show/Hide
|
C22H11Cl4NO3
|
1
|
| 1 |
IC50 = 506 nM
|
|
|
|
CP0576576
|
2-[5-chloro-2-methyl-3-[1-[4,4,4-trifluoro-3-(trifluoromethyl)butanoyl]piperidin-4-yl]oxyanilino]-6,7-dihydro-5H-1,3-benzothiazol-4-one
Show/Hide
|
C24H24ClF6N3O3S
|
1
|
| 1 |
IC50 = 533 nM
|
|
|
|
CP0391562
|
N-[(1-acetylpiperidin-4-yl)methyl]-1-ethyl-2-oxobenzo[cd]indole-6-sulfonamide
Show/Hide
|
C21H25N3O4S
|
2
|
| 1 |
IC50 = 590 nM
|
|
|
| 2 |
IC50 = 6030 nM
|
|
|
|
CP0493768
|
N-(4-acetylphenyl)-2-[N-(4-methylphenyl)sulfonyl-3-(trifluoromethyl)anilino]acetamide
Show/Hide
|
C24H21F3N2O4S
|
1
|
| 1 |
IC50 = 590 nM
|
|
|
|
CP0551211
|
N-[5-[[(3S)-4-(cyclopentanecarbonyl)-3-methylpiperazin-1-yl]methyl]-6-methyl-[1,2,4]triazolo[4,3-a]pyridin-7-yl]-6-methylpyridine-3-carboxamide
Show/Hide
|
C26H33N7O2
|
1
|
| 1 |
IC50 = 590 nM
|
|
|
|
CP0471702
|
(4-chlorophenyl)-(2,4-dichloro-3-phenylquinolin-6-yl)-(2,3-dimethylimidazol-4-yl)methanol
Show/Hide
|
C27H20Cl3N3O
|
1
|
| 1 |
IC50 = 600 nM
|
|
|
|
CP0551172
|
[4-[[3-(1,3-benzoxazol-2-ylamino)-2-methylphenyl]methyl]piperazin-1-yl]-cyclopentylmethanone
Show/Hide
|
C25H30N4O2
|
1
|
| 1 |
IC50 = 608 nM
|
|
|
|
CP0427585
|
2-chloro-4-[1-[2-chloro-6-(trifluoromethyl)benzoyl]-4-fluoroindazol-3-yl]benzoic acid
Show/Hide
|
C22H10Cl2F4N2O3
|
1
|
| 1 |
IC50 = 610 nM
|
|
|
|
CP0511103
|
N-(4-cyanophenyl)-2-[N-(4-methylphenyl)sulfonyl-4-(trifluoromethyl)anilino]acetamide
Show/Hide
|
C23H18F3N3O3S
|
1
|
| 1 |
IC50 = 620 nM
|
|
|
|
CP0407553
|
2-(N-benzylsulfonyl-4-methylanilino)-N-(4-cyanophenyl)acetamide
Show/Hide
|
C23H21N3O3S
|
1
|
| 1 |
IC50 = 630 nM
|
|
|
|
CP0483187
|
N-(4-cyanophenyl)-2-(3,4-dichloro-N-(4-methylphenyl)sulfonylanilino)acetamide
Show/Hide
|
C22H17Cl2N3O3S
|
1
|
| 1 |
IC50 = 630 nM
|
|
|
|
CP0471705
|
1-[4-chloro-2-methoxy-3-[(4-pyrazol-1-ylphenyl)methyl]quinolin-6-yl]-1-(4-chlorophenyl)-N-methyl-1-(3-methylimidazol-4-yl)methanamine
Show/Hide
|
C32H28Cl2N6O
|
1
|
| 1 |
IC50 = 630 nM
|
|
|
|
CP0464867
|
US9303015, 1
Show/Hide
|
C26H18Cl3N3O2
|
1
|
| 1 |
IC50 = 670 nM
|
|
|
|
CP0546324
|
cyclopentyl-[4-[[3-[(4-hydroxy-4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl)amino]-2-methylphenyl]methyl]piperazin-1-yl]methanone
Show/Hide
|
C25H34N4O2S
|
1
|
| 1 |
IC50 = 684 nM
|
|
|
|
CP0557379
|
2-amino-4-[1-[2-chloro-6-(trifluoromethyl)benzoyl]-4-fluoroindazol-3-yl]benzoic acid
Show/Hide
|
C22H12ClF4N3O3
|
1
|
| 1 |
IC50 = 687 nM
|
|
|
|
CP0189866
|
4-[3-(2,6-dichlorobenzoyl)-7-methoxyindol-1-yl]benzoic acid
Show/Hide
|
C23H15Cl2NO4
|
1
|
| 1 |
IC50 = 731 nM
|
|
|
|
CP0549957
|
cyclopentyl-[4-[[3-[(4-methoxy-4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl)amino]-2-methylphenyl]methyl]piperazin-1-yl]methanone
Show/Hide
|
C26H36N4O2S
|
1
|
| 1 |
IC50 = 789 nM
|
|
|
|
CP0347125
|
US9303015, 45
Show/Hide
|
C30H29Cl2N5O
|
1
|
| 1 |
IC50 = 810 nM
|
|
|
|
CP0471703
|
(4-chlorophenyl)-(2,4-dichloro-3-phenylquinolin-6-yl)-(3-ethylimidazol-4-yl)methanol
Show/Hide
|
C27H20Cl3N3O
|
1
|
| 1 |
IC50 = 820 nM
|
|
|
|
CP0412977
|
N-[4-[2-fluoro-4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]phenyl]heptanamide
Show/Hide
|
C22H22F7NO2
|
1
|
| 1 |
IC50 = 820 nM
|
|
|
|
CP0447830
|
US10201546, Example 133a
Show/Hide
|
C25H28ClN5O2
|
1
|
| 1 |
IC50 = 844 nM
|
|
|
|
CP0384027
|
US9303015, 43
Show/Hide
|
C26H19Cl3N4O
|
1
|
| 1 |
IC50 = 880 nM
|
|
|
|
CP0428582
|
N-(4-cyanophenyl)-2-[N-(4-methylphenyl)sulfonyl-3-(trifluoromethyl)anilino]acetamide
Show/Hide
|
C23H18F3N3O3S
|
1
|
| 1 |
IC50 = 900 nM
|
|
|
|
CP0420255
|
N-(4-cyanophenyl)-2-(4-fluoro-N-(4-methylphenyl)sulfonylanilino)acetamide
Show/Hide
|
C22H18FN3O3S
|
1
|
| 1 |
IC50 = 910 nM
|
|
|
|
CP0342623
|
US9303015, 42
Show/Hide
|
C27H18Cl3N3O
|
1
|
| 1 |
IC50 = 920 nM
|
|
|
|
CP0245521
|
N-(6-ethoxy-1,3-benzothiazol-2-yl)-1-ethyl-2-oxobenzo[cd]indole-6-sulfonamide
Show/Hide
|
C22H19N3O4S2
|
2
|
| 1 |
IC50 = 930 nM
|
|
|
| 2 |
IC50 = 1350 nM
|
|
|
|
CP0570069
|
methyl 5-[4-[2-fluoro-4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]anilino]-5-oxopentanoate
Show/Hide
|
C21H18F7NO4
|
1
|
| 1 |
IC50 = 930 nM
|
|
|
|
CP0579977
|
1-[4-[3-(1,3-benzothiazol-2-ylamino)-5-chloro-2-methylphenoxy]piperidin-1-yl]-4,4,4-trifluoro-3-(trifluoromethyl)butan-1-one
Show/Hide
|
C24H22ClF6N3O2S
|
1
|
| 1 |
IC50 = 940 nM
|
|
|
|
CP0384587
|
2-(2-aminophenyl)-N-[4-[2-fluoro-4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]phenyl]acetamide
Show/Hide
|
C23H17F7N2O2
|
1
|
| 1 |
IC50 = 960 nM
|
|
|
|
CP0254687
|
US9303015, 41
Show/Hide
|
C29H25Cl3N4O
|
1
|
| 1 |
IC50 = 1000 nM
|
|
|
|
CP0459079
|
(2,4-dichloro-3-phenylquinolin-6-yl)-(3-methylimidazol-4-yl)-pyridin-2-ylmethanol
Show/Hide
|
C25H18Cl2N4O
|
1
|
| 1 |
IC50 = 1000 nM
|
|
|
|
CP0546325
|
cyclopentyl-[4-[[3-(5,6-dihydro-4H-cyclopenta[d][1,3]thiazol-2-ylamino)-2-methylphenyl]methyl]piperazin-1-yl]methanone
Show/Hide
|
C24H32N4OS
|
1
|
| 1 |
IC50 = 1020 nM
|
|
|
|
CP0563599
|
N-cyclohexyl-2-[N-(4-methylphenyl)sulfonyl-3-(trifluoromethyl)anilino]acetamide
Show/Hide
|
C22H25F3N2O3S
|
1
|
| 1 |
IC50 = 1030 nM
|
|
|
|
CP0443789
|
4-cyclohexyl-N-[4-[2-fluoro-4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]phenyl]butanamide
Show/Hide
|
C25H26F7NO2
|
1
|
| 1 |
IC50 = 1080 nM
|
|
|
|
CP0534391
|
(3R,4R)-1-[1-[2-chloro-6-(trifluoromethyl)benzoyl]-4-fluoroindazol-3-yl]-3-hydroxypiperidine-4-carboxylic acid
Show/Hide
|
C21H16ClF4N3O4
|
1
|
| 1 |
IC50 = 1188 nM
|
|
|
|
CP0480117
|
1-ethyl-N-[(5-fluoro-1H-indol-2-yl)methyl]-2-oxobenzo[cd]indole-6-sulfonamide
Show/Hide
|
C22H18FN3O3S
|
2
|
| 1 |
IC50 = 1210 nM
|
|
|
| 2 |
IC50 = 12760 nM
|
|
|
|
CP0449943
|
US9346782, 5
Show/Hide
|
C23H21Cl2N3O
|
1
|
| 1 |
IC50 = 1300 nM
|
|
|
|
CP0438687
|
US9487490, 1E
Show/Hide
|
C21H15ClF3N3O3
|
1
|
| 1 |
IC50 = 1302 nM
|
|
|
|
CP0497978
|
2-(4-cyano-N-(4-methylphenyl)sulfonylanilino)-N-(4-cyanophenyl)acetamide
Show/Hide
|
C23H18N4O3S
|
1
|
| 1 |
IC50 = 1310 nM
|
|
|
|
CP0551171
|
cyclopentyl-[4-[[3-[[(4E)-4-methoxyimino-6,7-dihydro-5H-1,3-benzothiazol-2-yl]amino]-2-methylphenyl]methyl]piperazin-1-yl]methanone
Show/Hide
|
C26H35N5O2S
|
1
|
| 1 |
IC50 = 1330 nM
|
|
|
|
CP0499807
|
methyl 2-[[2-[N-(4-methylphenyl)sulfonyl-3-(trifluoromethyl)anilino]acetyl]amino]benzoate
Show/Hide
|
C24H21F3N2O5S
|
1
|
| 1 |
IC50 = 1390 nM
|
|
|
|
CP0578382
|
cyclopentyl-[4-[[2-methyl-3-([1,3]thiazolo[5,4-b]pyridin-2-ylamino)phenyl]methyl]piperazin-1-yl]methanone
Show/Hide
|
C24H29N5OS
|
1
|
| 1 |
IC50 = 1420 nM
|
|
|
|
CP0414643
|
N-(4-cyanophenyl)-2-(N-(4-fluorophenyl)sulfonyl-4-methylanilino)acetamide
Show/Hide
|
C22H18FN3O3S
|
1
|
| 1 |
IC50 = 1450 nM
|
|
|
|
CP0543698
|
N-[4-[2-fluoro-4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]phenyl]-1-(3-nitrophenyl)methanesulfonamide
Show/Hide
|
C22H15F7N2O5S
|
1
|
| 1 |
IC50 = 1490 nM
|
|
|
|
CP0571779
|
N-[4-[2-fluoro-4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]phenyl]-2-(4-nitrophenyl)acetamide
Show/Hide
|
C23H15F7N2O4
|
1
|
| 1 |
IC50 = 1490 nM
|
|
|
|
CP0095817
|
1-[4-[[4-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]phenyl]methyl]piperazin-1-yl]ethanone
Show/Hide
|
C22H22F6N2O2
|
1
|
| 1 |
IC50 = 1500 nM
|
|
|
|
CP0263708
|
US9346782, 4
Show/Hide
|
C24H23Cl2N3O
|
1
|
| 1 |
IC50 = 1500 nM
|
|
|
|
CP0551213
|
6-methyl-N-[7-methyl-8-[(2S,4R)-2-methyl-1-[4,4,4-trifluoro-3-(trifluoromethyl)butanoyl]piperidin-4-yl]oxy-[1,2,4]triazolo[1,5-a]pyridin-6-yl]pyridine-3-carboxamide
Show/Hide
|
C25H26F6N6O3
|
1
|
| 1 |
IC50 = 1500 nM
|
|
|
|
CP0570070
|
N-[4-[2-fluoro-4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]phenyl]-5-oxohexanamide
Show/Hide
|
C21H18F7NO3
|
1
|
| 1 |
IC50 = 1520 nM
|
|
|
|
CP0573835
|
cyclopentyl-[4-[[2-methyl-3-(4,5,6,7-tetrahydro-1,3-benzothiazol-2-ylamino)phenyl]methyl]piperazin-1-yl]methanone
Show/Hide
|
C25H34N4OS
|
1
|
| 1 |
IC50 = 1670 nM
|
|
|
|
CP0557461
|
US9346782, 6
Show/Hide
|
C25H26ClN3O4S
|
1
|
| 1 |
IC50 = 1700 nM
|
|
|
|
CP0546353
|
cyclopentyl-[4-[[2-methyl-3-([1,3]thiazolo[4,5-b]pyridin-2-ylamino)phenyl]methyl]piperazin-1-yl]methanone
Show/Hide
|
C24H29N5OS
|
1
|
| 1 |
IC50 = 1740 nM
|
|
|
|
CP0399107
|
N-(4-cyanophenyl)-2-[N-[(4-fluorophenyl)methylsulfonyl]-4-methylanilino]acetamide
Show/Hide
|
C23H20FN3O3S
|
1
|
| 1 |
IC50 = 1780 nM
|
|
|
|
CP0569625
|
N-[4-[2-fluoro-4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]phenyl]hexanamide
Show/Hide
|
C21H20F7NO2
|
1
|
| 1 |
IC50 = 1830 nM
|
|
|
|
CP0577867
|
[4-[[3-(1,3-benzothiazol-2-ylamino)-5-chloro-2-methylphenyl]methyl]piperazin-1-yl]-cyclopentylmethanone
Show/Hide
|
C25H29ClN4OS
|
1
|
| 1 |
IC50 = 1840 nM
|
|
|
|
CP0510305
|
2-[[4-chloro-6-[hydroxy-(3-methylimidazol-4-yl)-pyridin-4-ylmethyl]-3-phenylquinolin-2-yl]-methylamino]ethanol
Show/Hide
|
C28H26ClN5O2
|
1
|
| 1 |
IC50 = 1900 nM
|
|
|
|
CP0402940
|
N-[4-[2-fluoro-4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]phenyl]-3-phenylpropanamide
Show/Hide
|
C24H18F7NO2
|
1
|
| 1 |
IC50 = 1980 nM
|
|
|
|
CP0347124
|
US9303015, 44
Show/Hide
|
C35H37Cl2N5O3
|
1
|
| 1 |
IC50 = 2000 nM
|
|
|
|
CP0420321
|
(4-chlorophenyl)-(2,4-dimethoxy-3-phenylquinolin-6-yl)-(3-methylimidazol-4-yl)methanol
Show/Hide
|
C28H24ClN3O3
|
1
|
| 1 |
IC50 = 2000 nM
|
|
|
|
CP0438705
|
[4-chloro-3-[(4,4-difluorocyclohexyl)methyl]-2-methoxyquinolin-6-yl]-(2,6-dimethylpyridin-3-yl)-(3-methyltriazol-4-yl)methanol
Show/Hide
|
C28H30ClF2N5O2
|
1
|
| 1 |
IC50 = 2000 nM
|
|
|
|
CP0575103
|
4-[3-(2,6-dichlorobenzoyl)indol-1-yl]-2-methylbenzoic acid
Show/Hide
|
C23H15Cl2NO3
|
1
|
| 1 |
IC50 = 2010 nM
|
|
|
|
CP0557380
|
(3R,4S)-1-(1-(2- chloro-6- (trifluoromethyl)benzoyl)- 4-fluoro-1H-indazol-3-yl)- 3-hydroxypiperidine-4- carboxylic acid
Show/Hide
|
C21H16ClF4N3O4
|
1
|
| 1 |
IC50 = 2035 nM
|
|
|
|
CP0573623
|
[4-[[3-(1,3-benzothiazol-2-ylamino)-5-fluoro-2-methylphenyl]methyl]piperazin-1-yl]-cyclopentylmethanone
Show/Hide
|
C25H29FN4OS
|
1
|
| 1 |
IC50 = 2060 nM
|
|
|
|
CP0350607
|
US9303015, 18
Show/Hide
|
C27H21Cl2N3O3
|
1
|
| 1 |
IC50 = 2100 nM
|
|
|
|
CP0511701
|
(2,4-dichloro-3-phenylquinolin-6-yl)-phenyl-pyridin-4-ylmethanol
Show/Hide
|
C27H18Cl2N2O
|
1
|
| 1 |
IC50 = 2100 nM
|
|
|
|
CP0552968
|
N-[4-[2-fluoro-4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]phenyl]-1-(4-nitrophenyl)methanesulfonamide
Show/Hide
|
C22H15F7N2O5S
|
1
|
| 1 |
IC50 = 2220 nM
|
|
|
|
CP0464407
|
N-(3,4-dimethoxyphenyl)-2-[N-(4-methylphenyl)sulfonyl-3-(trifluoromethyl)anilino]acetamide
Show/Hide
|
C24H23F3N2O5S
|
1
|
| 1 |
IC50 = 2440 nM
|
|
|
|
CP0341216
|
tert-butyl N-[3-[(1-ethyl-2-oxobenzo[cd]indol-6-yl)sulfonylamino]phenyl]carbamate
Show/Hide
|
C24H25N3O5S
|
2
|
| 1 |
IC50 = 2510 nM
|
|
|
| 2 |
IC50 = 3390 nM
|
|
|
|
CP0546350
|
[4-[[3-(1,3-benzothiazol-2-ylamino)-2-methylphenyl]methyl]piperazin-1-yl]-cyclopentylmethanone
Show/Hide
|
C25H30N4OS
|
1
|
| 1 |
IC50 = 2620 nM
|
|
|
|
CP0393656
|
(4-chlorophenyl)-(4-chloro-3-phenylquinolin-6-yl)-(3-methylimidazol-4-yl)methanol
Show/Hide
|
C26H19Cl2N3O
|
1
|
| 1 |
IC50 = 2700 nM
|
|
|
|
CP0546326
|
[4-[[3-(1,3-benzothiazol-2-ylamino)-2,6-dimethylphenyl]methyl]piperazin-1-yl]-cyclopentylmethanone
Show/Hide
|
C26H32N4OS
|
1
|
| 1 |
IC50 = 2720 nM
|
|
|
|
CP0572715
|
2-[3-[[4-(cyclopentanecarbonyl)piperazin-1-yl]methyl]-2-methylanilino]-6,7-dihydro-5H-1,3-benzothiazol-4-one
Show/Hide
|
C25H32N4O2S
|
1
|
| 1 |
IC50 = 2870 nM
|
|
|
|
CP0552970
|
methyl 2-[[4-[2-fluoro-4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]phenyl]sulfamoylmethyl]benzoate
Show/Hide
|
C24H18F7NO5S
|
1
|
| 1 |
IC50 = 2960 nM
|
|
|
|
CP0570067
|
4,4,4-trifluoro-N-[4-[2-fluoro-4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]phenyl]butanamide
Show/Hide
|
C19H13F10NO2
|
1
|
| 1 |
IC50 = 3080 nM
|
|
|
|
CP0549207
|
4-[1-[(2,6-dichlorophenyl)methyl]indazol-3-yl]benzoic acid
Show/Hide
|
C21H14Cl2N2O2
|
1
|
| 1 |
IC50 = 3116 nM
|
|
|
|
CP0573099
|
[4-[[3-(1,3-benzothiazol-2-ylamino)-6-chloro-2-methylphenyl]methyl]piperazin-1-yl]-cyclopentylmethanone
Show/Hide
|
C25H29ClN4OS
|
1
|
| 1 |
IC50 = 3180 nM
|
|
|
|
CP0533360
|
N-[8-[[(3S)-4-(cyclopentanecarbonyl)-3-methylpiperazin-1-yl]methyl]-2,7-dimethyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl]-6-methylpyridine-3-carboxamide
Show/Hide
|
C27H35N7O2
|
1
|
| 1 |
IC50 = 3200 nM
|
|
|
|
CP0499806
|
N-(4-fluorophenyl)-2-[N-(4-methylphenyl)sulfonyl-3-(trifluoromethyl)anilino]acetamide
Show/Hide
|
C22H18F4N2O3S
|
1
|
| 1 |
IC50 = 3370 nM
|
|
|
|
CP0546323
|
cyclopentyl-[4-[[2-methyl-3-([1,3]thiazolo[4,5-b]pyrazin-2-ylamino)phenyl]methyl]piperazin-1-yl]methanone
Show/Hide
|
C23H28N6OS
|
1
|
| 1 |
IC50 = 3480 nM
|
|
|
|
CP0536420
|
2-[N-(4-methylphenyl)sulfonyl-3-(trifluoromethyl)anilino]-N-(4-methyl-1,3-thiazol-2-yl)acetamide
Show/Hide
|
C20H18F3N3O3S2
|
1
|
| 1 |
IC50 = 3650 nM
|
|
|
|
CP0455819
|
1-(1-(2-chloro-6- (trifluoromethyl)benzoyl)-1H- pyrazolo[4,3- b]pyridin-3- yl)piperidine-4- carboxylic acid
Show/Hide
|
C20H16ClF3N4O3
|
1
|
| 1 |
IC50 = 3766 nM
|
|
|
|
CP0511194
|
methyl 4-[[2-[N-(4-methylphenyl)sulfonyl-3-(trifluoromethyl)anilino]acetyl]amino]benzoate
Show/Hide
|
C24H21F3N2O5S
|
1
|
| 1 |
IC50 = 3980 nM
|
|
|
|
CP0533727
|
US9346782, 8
Show/Hide
|
C29H28ClF3N2O4
|
1
|
| 1 |
IC50 = 4000 nM
|
|
|
|
CP0562411
|
2-(4-aminophenyl)-N-[4-[2-fluoro-4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]phenyl]acetamide
Show/Hide
|
C23H17F7N2O2
|
1
|
| 1 |
IC50 = 4160 nM
|
|
|
|
CP0560071
|
N-[4-[2-fluoro-4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]phenyl]pentanamide
Show/Hide
|
C20H18F7NO2
|
1
|
| 1 |
IC50 = 4170 nM
|
|
|
|
CP0571778
|
methyl 3-[[4-[2-fluoro-4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]phenyl]sulfamoylmethyl]benzoate
Show/Hide
|
C24H18F7NO5S
|
1
|
| 1 |
IC50 = 4240 nM
|
|
|
|
CP0407552
|
N-(2,4-difluorophenyl)-2-[N-(4-methylphenyl)sulfonyl-3-(trifluoromethyl)anilino]acetamide
Show/Hide
|
C22H17F5N2O3S
|
1
|
| 1 |
IC50 = 4540 nM
|
|
|
|
CP0434664
|
N-(2-tert-butylphenyl)-1-ethyl-2-oxobenzo[cd]indole-6-sulfonamide
Show/Hide
|
C23H24N2O3S
|
2
|
| 1 |
IC50 = 4900 nM
|
|
|
| 2 |
IC50 = 9980 nM
|
|
|
|
CP0382312
|
1-ethyl-2-oxo-N-(3-sulfamoylphenyl)benzo[cd]indole-6-sulfonamide
Show/Hide
|
C19H17N3O5S2
|
1
|
| 1 |
IC50 = 5150 nM
|
|
|
|
CP0546006
|
US9303015, 22a
Show/Hide
|
C28H17F3N6O2
|
1
|
| 1 |
IC50 = 6000 nM
|
|
|
|
CP0403337
|
[4-chloro-3-[(4-fluorophenyl)methyl]-2-methoxyquinolin-6-yl]-(4-chlorophenyl)-(3-methylimidazol-4-yl)methanol
Show/Hide
|
C28H22Cl2FN3O2
|
1
|
| 1 |
IC50 = 6000 nM
|
|
|
|
CP0459886
|
[4-chloro-3-[(4-fluorophenyl)methyl]-2-methoxyquinolin-6-yl]-(3-methylimidazol-4-yl)-[6-(trifluoromethyl)pyridin-3-yl]methanol
Show/Hide
|
C28H21ClF4N4O2
|
1
|
| 1 |
IC50 = 6000 nM
|
|
|
|
CP0497977
|
methyl 3-[[2-[N-(4-methylphenyl)sulfonyl-3-(trifluoromethyl)anilino]acetyl]amino]benzoate
Show/Hide
|
C24H21F3N2O5S
|
1
|
| 1 |
IC50 = 6060 nM
|
|
|
|
CP0573836
|
cyclopentyl-[4-[[2-methyl-3-(5,6,7,8-tetrahydro-4H-cyclohepta[d][1,3]thiazol-2-ylamino)phenyl]methyl]piperazin-1-yl]methanone
Show/Hide
|
C26H36N4OS
|
1
|
| 1 |
IC50 = 6220 nM
|
|
|
|
CP0511196
|
N-[(4-fluorophenyl)methyl]-2-[N-(4-methylphenyl)sulfonyl-3-(trifluoromethyl)anilino]acetamide
Show/Hide
|
C23H20F4N2O3S
|
1
|
| 1 |
IC50 = 7510 nM
|
|
|
|
CP0562410
|
1-(4-cyanophenyl)-N-[4-[2-fluoro-4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]phenyl]methanesulfonamide
Show/Hide
|
C23H15F7N2O3S
|
1
|
| 1 |
IC50 = 7550 nM
|
|
|
|
CP0411808
|
N-(7,7-dimethyl-9-oxo-6,8-dihydrodibenzofuran-3-yl)-2-oxo-1H-benzo[cd]indole-6-sulfonamide
Show/Hide
|
C25H20N2O5S
|
2
|
| 1 |
IC50 = 7560 nM
|
|
|
| 2 |
IC50 = 11840 nM
|
|
|
|
CP0421940
|
N-[4-[2-fluoro-4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]phenyl]-1-(2-nitrophenyl)methanesulfonamide
Show/Hide
|
C22H15F7N2O5S
|
1
|
| 1 |
IC50 = 7660 nM
|
|
|
|
CP0568132
|
N-[4-[2-fluoro-4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]phenyl]-1-(4-methylsulfonylphenyl)methanesulfonamide
Show/Hide
|
C23H18F7NO5S2
|
1
|
| 1 |
IC50 = 7760 nM
|
|
|
|
CP0469347
|
N-[5-[[(3S)-4-(cyclopentanecarbonyl)-3-methylpiperazin-1-yl]methyl]-3,6-dimethyl-[1,2,4]triazolo[4,3-a]pyridin-7-yl]-6-methylpyridine-3-carboxamide
Show/Hide
|
C27H35N7O2
|
1
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| 1 |
IC50 = 8000 nM
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CP0421939
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4-[[4-[2-fluoro-4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]phenyl]sulfamoylmethyl]-N-methylbenzamide
Show/Hide
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C24H19F7N2O4S
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1
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| 1 |
IC50 = 8050 nM
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CP0536422
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2-[N-(4-methylphenyl)sulfonyl-3-(trifluoromethyl)anilino]-N-(pyridin-4-ylmethyl)acetamide
Show/Hide
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C22H20F3N3O3S
|
1
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| 1 |
IC50 = 8280 nM
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CP0464406
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N-(4-hydroxyphenyl)-2-[N-(4-methylphenyl)sulfonyl-3-(trifluoromethyl)anilino]acetamide
Show/Hide
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C22H19F3N2O4S
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1
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| 1 |
IC50 = 8340 nM
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CP0571777
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4-[[4-[2-fluoro-4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]phenyl]sulfamoylmethyl]benzamide
Show/Hide
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C23H17F7N2O4S
|
1
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| 1 |
IC50 = 8720 nM
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|
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CP0476296
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6-methyl-N-[7-methyl-8-[[(3S)-3-methyl-4-(oxane-4-carbonyl)piperazin-1-yl]methyl]-[1,2,4]triazolo[1,5-a]pyridin-6-yl]pyridine-3-carboxamide
Show/Hide
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C26H33N7O3
|
1
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| 1 |
IC50 = 10000 nM
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|
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CP0472933
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N-[2-(4-acetylpiperazin-1-yl)-2-oxoethyl]-4-methyl-N-[3-(trifluoromethyl)phenyl]benzenesulfonamide
Show/Hide
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C22H24F3N3O4S
|
1
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| 1 |
IC50 = 10430 nM
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|
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CP0472934
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N-[(4-hydroxyphenyl)methyl]-2-[N-(4-methylphenyl)sulfonyl-3-(trifluoromethyl)anilino]acetamide
Show/Hide
|
C23H21F3N2O4S
|
1
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| 1 |
IC50 = 22050 nM
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|
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CP0497976
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N-[(4-methylphenyl)methyl]-2-[N-(4-methylphenyl)sulfonyl-3-(trifluoromethyl)anilino]acetamide
Show/Hide
|
C24H23F3N2O3S
|
1
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| 1 |
IC50 = 27220 nM
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CP0053526
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3-(1,3-benzodioxol-5-yl)-1-(3,5-dimethylpiperidin-1-yl)-3-(2-hydroxy-5-propoxyphenyl)propan-1-one
Show/Hide
|
C26H33NO5
|
1
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| 1 |
IC50 > 1000 nM
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|
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CP0156193
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3-(1,3-benzodioxol-5-yl)-1-(3,5-dimethylpiperidin-1-yl)-3-(2-hydroxy-6-phenoxyphenyl)propan-1-one
Show/Hide
|
C29H31NO5
|
1
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| 1 |
IC50 > 1000 nM
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|
|
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CP0191950
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3-(1,3-benzodioxol-5-yl)-1-(3,5-dimethylpiperidin-1-yl)-3-(5-ethoxy-2-hydroxyphenyl)propan-1-one
Show/Hide
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C25H31NO5
|
1
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| 1 |
IC50 > 1000 nM
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|
|
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CP0254159
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1-(3,5-dimethylpiperidin-1-yl)-3-(2-hydroxynaphthalen-1-yl)-3-(4-methylphenyl)propan-1-one
Show/Hide
|
C27H31NO2
|
1
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| 1 |
IC50 > 1000 nM
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|
|
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CP0309303
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3-(1,3-benzodioxol-5-yl)-3-(2-hydroxy-4,6-dimethoxyphenyl)-1-(4-phenylpiperidin-1-yl)propan-1-one
Show/Hide
|
C29H31NO6
|
1
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| 1 |
IC50 > 1000 nM
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|
|
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CP0327016
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3-(1,3-benzodioxol-5-yl)-1-(3,5-dimethylpiperidin-1-yl)-3-(2-hydroxy-5-methylphenyl)propan-1-one
Show/Hide
|
C24H29NO4
|
1
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| 1 |
IC50 > 1000 nM
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|
|
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CP0331534
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3-(1,3-benzodioxol-5-yl)-1-(3,5-dimethylpiperidin-1-yl)-3-(2-hydroxynaphthalen-1-yl)propan-1-one
Show/Hide
|
C27H29NO4
|
1
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| 1 |
IC50 > 1000 nM
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|
|
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CP0331535
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3-(1,3-benzodioxol-5-yl)-1-(3,5-dimethylpiperidin-1-yl)-3-(5-ethyl-2-hydroxyphenyl)propan-1-one
Show/Hide
|
C25H31NO4
|
1
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| 1 |
IC50 > 1000 nM
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|
|
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CP0331536
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3-(1,3-benzodioxol-5-yl)-3-(2-hydroxy-4,6-dimethoxyphenyl)-1-[3-(trifluoromethyl)piperidin-1-yl]propan-1-one
Show/Hide
|
C24H26F3NO6
|
1
|
| 1 |
IC50 > 1000 nM
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|
|
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CP0418477
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3-(1,3-benzodioxol-5-yl)-1-(3,5-dimethylpiperidin-1-yl)-3-(2-hydroxy-6-methylphenyl)propan-1-one
Show/Hide
|
C24H29NO4
|
1
|
| 1 |
IC50 > 1000 nM
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|
|
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CP0359928
|
4-[3-(2,6-dichlorobenzoyl)indol-1-yl]-2-(trifluoromethyl)benzoic acid
Show/Hide
|
C23H12Cl2F3NO3
|
1
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| 1 |
IC50 > 1000 nM
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|
|
|
CP0242454
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4-[3-(2,6-dichlorobenzoyl)indol-1-yl]-3-(trifluoromethyl)benzoic acid
Show/Hide
|
C23H12Cl2F3NO3
|
1
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| 1 |
IC50 > 3000 nM
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|
|
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CP0393660
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(4-chlorophenyl)-(2-chloro-3-phenylquinolin-6-yl)-(3-methylimidazol-4-yl)methanol
Show/Hide
|
C26H19Cl2N3O
|
1
|
| 1 |
IC50 > 4000 nM
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|
|
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CP0180490
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4-[3-(2,6-dichlorobenzoyl)-2-methylindol-1-yl]benzoic acid
Show/Hide
|
C23H15Cl2NO3
|
1
|
| 1 |
IC50 > 5000 nM
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|
|
|
CP0556180
|
US9303015, 46
Show/Hide
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C27H16Cl2F6N4O2
|
1
|
| 1 |
IC50 > 6000 nM
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|
|
|
CP0187424
|
US9346782, 3
Show/Hide
|
C23H19Cl2N3O
|
1
|
| 1 |
IC50 > 6000 nM
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|
|
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CP0429547
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(3-benzyl-4-chloro-2-methoxyquinolin-6-yl)-(3-methylimidazol-4-yl)-[6-(trifluoromethyl)pyridin-3-yl]methanol
Show/Hide
|
C28H22ClF3N4O2
|
1
|
| 1 |
IC50 > 6000 nM
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|
|
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CP0558605
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[2-chloro-4-(methylamino)-3-phenylquinolin-6-yl]-(3-methylimidazol-4-yl)-pyridin-4-ylmethanol
Show/Hide
|
C26H22ClN5O
|
1
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| 1 |
IC50 > 6000 nM
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|
|
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CP0476935
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(2,4-dichloro-3-phenylquinolin-6-yl)-(2-fluoropyridin-4-yl)-(1-methylimidazol-2-yl)methanol
Show/Hide
|
C25H17Cl2FN4O
|
1
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| 1 |
IC50 > 6000 nM
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|
|
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CP0560515
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[4-chloro-3-[(4-fluoropiperidin-1-yl)methyl]-2-methoxyquinolin-6-yl]-(2,6-dimethylpyridin-3-yl)-(3-methyltriazol-4-yl)methanol
Show/Hide
|
C27H30ClFN6O2
|
1
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| 1 |
IC50 > 6000 nM
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