Brief Information of the Compound and Protein
Compound Name
 Compound Info 
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(2,2,2-trifluoroethyl)benzenesulfonamide
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 PubChem ID
CID: 447912
SID: 14932512
Canonical SMILES
OC(c1ccc(cc1)N(CC(F)(F)F)S(=O)(=O)c1ccccc1)(C(F)(F)F)C(F)(F)F
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Compound Formula C17H12F9NO3S
Compound Structure
Protein Name
 Protein Info 
Nuclear receptor ROR-gamma
Protein Classification
Transcription factor
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Nuclear receptor
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Nuclear hormone receptor subfamily 1
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Nuclear hormone receptor subfamily 1 group F
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Nuclear hormone receptor subfamily 1 group F member 3
Uniprot ID
P51449
Gene Name
RORC
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000025 HEK-293T
 Cell Line Info 
Homo sapiens (Human)  5
1
IC50 = 330 nM
   TI
   LI
   LO
   TS
2
IC50 = 540 nM
   TI
   LI
   LO
   TS
3
IC50 = 810 nM
   TI
   LI
   LO
   TS
4
IC50 = 1700 nM
   TI
   LI
   LO
   TS
5
IC50 = 3500 nM
   TI
   LI
   LO
   TS
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  2
1
IC50 = 4400 nM
   TI
   LI
   LO
   TS
2
IC50 = 6500 nM
   TI
   LI
   LO
   TS
CL000001 Jurkat
 Cell Line Info 
Homo sapiens (Human)  1
1
EC50 = 333 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 60 nM
2 IC50 = 204 nM
3 IC50 = 501.19 nM
4 IC50 = 1700 nM
5 IC50 = 2010 nM
6 Ki = 51 nM