| Compound ID |
Compound Name |
Compound Formula |
|
CP0427828
|
3-(cyclopropylmethyl)-7-[(3-methyl-3-phenylpiperidin-1-yl)methyl]-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine
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|
C24H27F3N4
|
1
|
| 1 |
EC50 = 2.6 nM
|
|
|
|
CP0441825
|
3-(cyclopropylmethyl)-7-[4-(3,6-difluoro-2-methoxyphenyl)piperidin-1-yl]-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine
Show/Hide
|
C23H23F5N4O
|
1
|
| 1 |
EC50 = 4.1 nM
|
|
|
|
CP0427760
|
8-chloro-3-(cyclopropylmethyl)-7-[4-(2-fluoro-6-methoxyphenyl)piperidin-1-yl]-[1,2,4]triazolo[4,3-a]pyridine
Show/Hide
|
C22H24ClFN4O
|
2
|
| 1 |
EC50 = 6 nM
|
|
|
| 2 |
IC50 = 11.2 nM
|
|
|
|
CP0458978
|
8-chloro-3-(cyclopropylmethyl)-7-[4-(2,4-difluoro-6-methoxyphenyl)piperidin-1-yl]-[1,2,4]triazolo[4,3-a]pyridine
Show/Hide
|
C22H23ClF2N4O
|
2
|
| 1 |
EC50 = 6.9 nM
|
|
|
| 2 |
IC50 = 5.6 nM
|
|
|
|
CP0054204
|
8-chloro-3-(cyclopropylmethyl)-7-[4-(3,6-difluoro-2-methoxyphenyl)piperidin-1-yl]-[1,2,4]triazolo[4,3-a]pyridine
Show/Hide
|
C22H23ClF2N4O
|
2
|
| 1 |
EC50 = 7.5 nM
|
|
|
| 2 |
IC50 = 9.23 nM
|
|
|
|
CP0054201
|
8-chloro-3-(cyclopropylmethyl)-7-[4-(5-fluoro-2-methoxyphenyl)piperidin-1-yl]-[1,2,4]triazolo[4,3-a]pyridine
Show/Hide
|
C22H24ClFN4O
|
2
|
| 1 |
EC50 = 8.2 nM
|
|
|
| 2 |
IC50 = 11.2 nM
|
|
|
|
CP0427757
|
8-chloro-3-(cyclopropylmethyl)-7-[4-(2,3-difluoro-6-methoxyphenyl)piperidin-1-yl]-[1,2,4]triazolo[4,3-a]pyridine
Show/Hide
|
C22H23ClF2N4O
|
2
|
| 1 |
EC50 = 9.3 nM
|
|
|
| 2 |
IC50 = 7.3 nM
|
|
|
|
CP0475736
|
3-(cyclopropylmethyl)-7-[[4-(2,6-difluorophenyl)piperidin-1-yl]methyl]-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine
Show/Hide
|
C23H23F5N4
|
1
|
| 1 |
EC50 = 9.7 nM
|
|
|
|
CP0412874
|
3-(cyclopropylmethyl)-7-[4-(2,4-difluorophenyl)piperidin-1-yl]-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine
Show/Hide
|
C22H21F5N4
|
1
|
| 1 |
EC50 = 10 nM
|
|
|
|
CP0427758
|
8-chloro-7-[4-(5-fluoro-2-methoxyphenyl)piperidin-1-yl]-3-(2,2,2-trifluoroethyl)-[1,2,4]triazolo[4,3-a]pyridine
Show/Hide
|
C20H19ClF4N4O
|
1
|
| 1 |
EC50 = 10.5 nM
|
|
|
|
CP0458977
|
3-(cyclopropylmethyl)-7-[4-(3-fluoro-2-methoxyphenyl)piperidin-1-yl]-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine
Show/Hide
|
C23H24F4N4O
|
1
|
| 1 |
EC50 = 11 nM
|
|
|
|
CP0451567
|
7-[[4-(2-chlorophenyl)piperidin-1-yl]methyl]-3-(cyclopropylmethyl)-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine
Show/Hide
|
C23H24ClF3N4
|
1
|
| 1 |
EC50 = 13.5 nM
|
|
|
|
CP0468146
|
3-[3-[[1-(2,2-dimethylpropyl)-3-methyl-2-oxobenzimidazol-5-yl]oxymethyl]phenyl]-5-fluorobenzoic acid
Show/Hide
|
C27H27FN2O4
|
1
|
| 1 |
EC50 = 15 nM
|
|
|
|
CP0458064
|
3-(cyclopropylmethyl)-7-[[4-(2,4-difluorophenyl)piperidin-1-yl]methyl]-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine
Show/Hide
|
C23H23F5N4
|
1
|
| 1 |
EC50 = 15 nM
|
|
|
|
CP0475735
|
3-(cyclopropylmethyl)-7-[[4-(2-fluorophenyl)piperidin-1-yl]methyl]-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine
Show/Hide
|
C23H24F4N4
|
1
|
| 1 |
EC50 = 15 nM
|
|
|
|
CP0140486
|
1-(2,2-dimethylpropyl)-3-methyl-5-[(1S,4R)-2-(1,2-oxazole-3-carbonyl)-2-azabicyclo[2.2.2]oct-5-en-5-yl]imidazo[4,5-b]pyridin-2-one
Show/Hide
|
C23H27N5O3
|
1
|
| 1 |
EC50 = 16 nM
|
|
|
|
CP0070721
|
3-(cyclopropylmethyl)-7-(4-phenylpiperidin-1-yl)-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine
Show/Hide
|
C22H23F3N4
|
3
|
| 1 |
EC50 = 17 nM
|
|
|
| 2 |
EC50 = 270 nM
|
|
|
| 3 |
IC50 = 15 nM
|
|
|
|
CP0454695
|
3-(cyclopropylmethyl)-7-[[4-(2,4-dichlorophenyl)piperazin-1-yl]methyl]-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine
Show/Hide
|
C22H22Cl2F3N5
|
1
|
| 1 |
EC50 = 17 nM
|
|
|
|
CP0003618
|
8-chloro-3-(cyclopropylmethyl)-7-[4-(2-methoxyphenyl)piperidin-1-yl]-[1,2,4]triazolo[4,3-a]pyridine
Show/Hide
|
C22H25ClN4O
|
1
|
| 1 |
EC50 = 20 nM
|
|
|
|
CP0125935
|
3-(cyclopropylmethyl)-7-[(4-phenylpiperidin-1-yl)methyl]-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine
Show/Hide
|
C23H25F3N4
|
1
|
| 1 |
EC50 = 21 nM
|
|
|
|
CP0519593
|
3-(cyclopropylmethyl)-7-[[4-(2,4-difluorophenyl)-1,4-diazepan-1-yl]methyl]-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine
Show/Hide
|
C23H24F5N5
|
1
|
| 1 |
EC50 = 22 nM
|
|
|
|
CP0413713
|
3-butyl-7-(4-phenylpiperidin-1-yl)-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine
Show/Hide
|
C22H25F3N4
|
1
|
| 1 |
EC50 = 24 nM
|
|
|
|
CP0427759
|
8-chloro-3-(cyclopropylmethyl)-7-[4-(3,4-difluoro-2-methoxyphenyl)piperidin-1-yl]-[1,2,4]triazolo[4,3-a]pyridine
Show/Hide
|
C22H23ClF2N4O
|
1
|
| 1 |
EC50 = 26 nM
|
|
|
|
CP0536392
|
2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxoimidazo[4,5-b]pyridin-5-yl]benzonitrile
Show/Hide
|
C19H20N4O
|
1
|
| 1 |
EC50 = 26 nM
|
|
|
|
CP0376958
|
3-(cyclopropylmethyl)-7-[(4-methoxy-4-phenylpiperidin-1-yl)methyl]-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine
Show/Hide
|
C24H27F3N4O
|
1
|
| 1 |
EC50 = 26 nM
|
|
|
|
CP0427830
|
3-(cyclopropylmethyl)-7-[[4-(2,6-difluorophenyl)piperazin-1-yl]methyl]-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine
Show/Hide
|
C22H22F5N5
|
1
|
| 1 |
EC50 = 26 nM
|
|
|
|
CP0440056
|
3'-((2-cyclopentyl-6,7-dimethyl-1-oxo-2,3-dihydro-1H-inden-5-yloxy)methyl)-biphenyl-4-carboxylic acid
Show/Hide
|
C30H30O4
|
1
|
| 1 |
EC50 = 27.54 nM
|
|
|
|
CP0047319
|
1-(2,2-dimethylpropyl)-3-methyl-5-[(1S,4S)-5-(thiadiazole-4-carbonyl)-2,5-diazabicyclo[2.2.2]octan-2-yl]imidazo[4,5-b]pyridin-2-one
Show/Hide
|
C21H27N7O2S
|
2
|
| 1 |
EC50 = 29 nM
|
|
|
| 2 |
EC50 = 637 nM
|
|
|
|
CP0140519
|
1-(2,2-dimethylpropyl)-3-methyl-5-[(1S,4S)-5-(1,2-oxazole-3-carbonyl)-2,5-diazabicyclo[2.2.2]octan-2-yl]imidazo[4,5-b]pyridin-2-one
Show/Hide
|
C22H28N6O3
|
2
|
| 1 |
EC50 = 29 nM
|
|
|
| 2 |
EC50 = 668 nM
|
|
|
|
CP0515480
|
1-butyl-4-[3-chloro-4-(2,6-dimethylpyridin-3-yl)oxyphenyl]-2-oxopyridine-3-carbonitrile
Show/Hide
|
C23H22ClN3O2
|
1
|
| 1 |
EC50 = 30 nM
|
|
|
|
CP0217750
|
2,2,2-Trifluoro-ethanesulfonic acid [3-(1-methyl-butoxy)-phenyl]-pyridin-3-ylmethyl-amide
Show/Hide
|
C19H23F3N2O3S
|
1
|
| 1 |
EC50 = 30.9 nM
|
|
|
|
CP0493639
|
7-[4-(3-fluoro-2-methoxyphenyl)piperidin-1-yl]-3-(2,2,2-trifluoroethyl)-[1,2,4]triazolo[4,3-a]pyridine-8-carbonitrile
Show/Hide
|
C21H19F4N5O
|
1
|
| 1 |
EC50 = 31 nM
|
|
|
|
CP0510968
|
1-(cyclopropylmethyl)-4-[4-(2,6-difluorophenyl)piperidin-1-yl]-2-oxopyridine-3-carbonitrile
Show/Hide
|
C21H21F2N3O
|
1
|
| 1 |
EC50 = 31 nM
|
|
|
|
CP0385037
|
1-(2,2-dimethylpropyl)-3-methyl-5-phenylbenzimidazol-2-one
Show/Hide
|
C19H22N2O
|
1
|
| 1 |
EC50 = 31 nM
|
|
|
|
CP0533014
|
1-(cyclopropylmethyl)-4-[4-(2-methoxyphenyl)piperidin-1-yl]-2-oxopyridine-3-carbonitrile
Show/Hide
|
C22H25N3O2
|
1
|
| 1 |
EC50 = 35 nM
|
|
|
|
CP0452556
|
5-(5-benzoyl-2,5-diazabicyclo[2.2.2]octan-2-yl)-1-(2,2-dimethylpropyl)-3-methylimidazo[4,5-b]pyridin-2-one
Show/Hide
|
C25H31N5O2
|
1
|
| 1 |
EC50 = 36 nM
|
|
|
|
CP0441949
|
8-chloro-3-(cyclopropylmethyl)-7-[4-(3-fluoro-2-methoxyphenyl)piperidin-1-yl]-[1,2,4]triazolo[4,3-a]pyridine
Show/Hide
|
C22H24ClFN4O
|
1
|
| 1 |
EC50 = 37 nM
|
|
|
|
CP0380298
|
1-(2,2-dimethylpropyl)-3-methyl-5-(5-pyrimidin-2-yl-2,5-diazabicyclo[2.2.2]octan-2-yl)imidazo[4,5-b]pyridin-2-one
Show/Hide
|
C22H29N7O
|
1
|
| 1 |
EC50 = 37 nM
|
|
|
|
CP0427829
|
N-[[3-(cyclopropylmethyl)-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridin-7-yl]methyl]-4-(2,4-difluorophenyl)cyclohexan-1-amine
Show/Hide
|
C24H25F5N4
|
1
|
| 1 |
EC50 = 38 nM
|
|
|
|
CP0453527
|
3-(cyclopropylmethyl)-7-(4-fluoro-4-phenylpiperidin-1-yl)-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine
Show/Hide
|
C22H22F4N4
|
1
|
| 1 |
EC50 = 39 nM
|
|
|
|
CP0439090
|
2-[[4-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]piperidin-1-yl]methyl]-1-methylbenzimidazole
Show/Hide
|
C20H20ClF3N4
|
2
|
| 1 |
EC50 = 39.81 nM
|
|
|
| 2 |
EC50 = 630.96 nM
|
|
|
|
CP0315343
|
1-(3-methylbutyl)-2-oxo-4-(4-phenoxyphenyl)pyridine-3-carbonitrile
Show/Hide
|
C23H22N2O2
|
1
|
| 1 |
EC50 = 42 nM
|
|
|
|
CP0463598
|
1-(cyclopropylmethyl)-2-oxo-4-[4-[3-(trifluoromethyl)phenyl]piperidin-1-yl]pyridine-3-carbonitrile
Show/Hide
|
C22H22F3N3O
|
1
|
| 1 |
EC50 = 46 nM
|
|
|
|
CP0492417
|
4-[4-(4-chlorophenyl)piperidin-1-yl]-1-(cyclopropylmethyl)-2-oxopyridine-3-carbonitrile
Show/Hide
|
C21H22ClN3O
|
1
|
| 1 |
EC50 = 48 nM
|
|
|
|
CP0508220
|
4-[4-(2-chlorophenyl)piperidin-1-yl]-1-(cyclopropylmethyl)-2-oxopyridine-3-carbonitrile
Show/Hide
|
C21H22ClN3O
|
1
|
| 1 |
EC50 = 49 nM
|
|
|
|
CP0176186
|
2-[1-(2,2-dimethylpropyl)-3-methyl-2-oxoimidazo[4,5-b]pyridin-5-yl]-4-(2-hydroxypropan-2-yl)benzonitrile
Show/Hide
|
C22H26N4O2
|
1
|
| 1 |
EC50 = 49 nM
|
|
|
|
CP0475100
|
2-[[4-[6-chloro-3-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]methyl]-1-methylbenzimidazole-5-carbonitrile
Show/Hide
|
C20H18ClF3N6
|
1
|
| 1 |
EC50 = 50.12 nM
|
|
|
|
CP0499580
|
8-chloro-7-(4-phenylpiperidin-1-yl)-3-(2,2,2-trifluoroethyl)-[1,2,4]triazolo[4,3-a]pyridine
Show/Hide
|
C19H18ClF3N4
|
1
|
| 1 |
EC50 = 55 nM
|
|
|
|
CP0536848
|
1-(cyclobutylmethyl)-2-oxo-4-(4-phenylpiperidin-1-yl)pyridine-3-carbonitrile
Show/Hide
|
C22H25N3O
|
1
|
| 1 |
EC50 = 55 nM
|
|
|
|
CP0413715
|
7-(4-phenylpiperidin-1-yl)-3-(2,2,2-trifluoroethyl)-[1,2,4]triazolo[4,3-a]pyridine-8-carbonitrile
Show/Hide
|
C20H18F3N5
|
2
|
| 1 |
EC50 = 56 nM
|
|
|
| 2 |
EC50 = 56.23 nM
|
|
|
|
CP0538614
|
1-(2,2-dimethylpropyl)-3-methyl-5-(2-methylphenyl)imidazo[4,5-b]pyridin-2-one
Show/Hide
|
C19H23N3O
|
1
|
| 1 |
EC50 = 57 nM
|
|
|
|
CP0427820
|
3-(cyclopropylmethyl)-7-[[4-[(2,4-difluorophenyl)methoxy]piperidin-1-yl]methyl]-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine
Show/Hide
|
C24H25F5N4O
|
1
|
| 1 |
EC50 = 57 nM
|
|
|
|
CP0510161
|
3-(cyclopropylmethyl)-7-[[4-(2,4-difluorophenoxy)piperidin-1-yl]methyl]-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine
Show/Hide
|
C23H23F5N4O
|
1
|
| 1 |
EC50 = 57 nM
|
|
|
|
CP0475734
|
3-(cyclopropylmethyl)-7-[[4-phenyl-4-(trifluoromethyl)piperidin-1-yl]methyl]-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine
Show/Hide
|
C24H24F6N4
|
1
|
| 1 |
EC50 = 58 nM
|
|
|
|
CP0047317
|
1-(2,2-dimethylpropyl)-5-[5-(2-hydroxypropan-2-yl)-2-methylphenyl]-3-methylimidazo[4,5-b]pyridin-2-one
Show/Hide
|
C22H29N3O2
|
2
|
| 1 |
EC50 = 61 nM
|
|
|
| 2 |
EC50 = 63 nM
|
|
|
|
CP0499593
|
8-chloro-3-(cyclopropylmethyl)-7-[4-(2,4-difluorophenyl)piperidin-1-yl]-[1,2,4]triazolo[4,3-a]pyridine
Show/Hide
|
C21H21ClF2N4
|
1
|
| 1 |
EC50 = 61.66 nM
|
|
|
|
CP0513956
|
2-[[4-[3-chloro-6-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]methyl]-1-ethylbenzimidazole
Show/Hide
|
C20H21ClF3N5
|
1
|
| 1 |
EC50 = 63.1 nM
|
|
|
|
CP0450657
|
4-[3-chloro-4-(2,6-dimethylpyridin-3-yl)oxyphenyl]-1-(cyclopropylmethyl)-2-oxopyridine-3-carbonitrile
Show/Hide
|
C23H20ClN3O2
|
1
|
| 1 |
EC50 = 64 nM
|
|
|
|
CP0376960
|
3-(cyclopropylmethyl)-7-[(3-phenylpiperidin-1-yl)methyl]-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine
Show/Hide
|
C23H25F3N4
|
1
|
| 1 |
EC50 = 65 nM
|
|
|
|
CP0398770
|
1-(cyclopropylmethyl)-4-[4-(2,4-difluorophenyl)piperidin-1-yl]-2-oxopyridine-3-carbonitrile
Show/Hide
|
C21H21F2N3O
|
1
|
| 1 |
EC50 = 68 nM
|
|
|
|
CP0447800
|
1-(2,2-dimethylpropyl)-3-methyl-5-phenylimidazo[4,5-b]pyridin-2-one
Show/Hide
|
C18H21N3O
|
1
|
| 1 |
EC50 = 70 nM
|
|
|
|
CP0413721
|
3-(cyclopropylmethyl)-7-(4-phenylpiperidin-1-yl)-[1,2,4]triazolo[4,3-a]pyridine-8-carbonitrile
Show/Hide
|
C22H23N5
|
1
|
| 1 |
EC50 = 74 nM
|
|
|
|
CP0046845
|
3-(cyclopropylmethyl)-7-[[4-(2,4-difluorophenyl)piperazin-1-yl]methyl]-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine
Show/Hide
|
C22H22F5N5
|
1
|
| 1 |
EC50 = 78 nM
|
|
|
|
CP0234177
|
2-[[4-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]methyl]-1-methylbenzimidazole
Show/Hide
|
C19H19ClF3N5
|
2
|
| 1 |
EC50 = 79.43 nM
|
|
|
| 2 |
EC50 = 1995.26 nM
|
|
|
|
CP0422138
|
2-[[4-(4-chlorophenyl)piperidin-1-yl]methyl]-1-methylbenzimidazole
Show/Hide
|
C20H22ClN3
|
2
|
| 1 |
EC50 = 79.43 nM
|
|
|
| 2 |
EC50 = 5011.87 nM
|
|
|
|
CP0456797
|
3-[1-(2,2-dimethylpropyl)-3-methyl-2-oxoimidazo[4,5-b]pyridin-5-yl]benzonitrile
Show/Hide
|
C19H20N4O
|
1
|
| 1 |
EC50 = 80 nM
|
|
|
|
CP0508219
|
1-(cyclopropylmethyl)-4-[4-(2-fluorophenyl)piperidin-1-yl]-2-oxopyridine-3-carbonitrile
Show/Hide
|
C21H22FN3O
|
1
|
| 1 |
EC50 = 81 nM
|
|
|
|
CP0474408
|
1-(2,2-dimethylpropyl)-5-(2-fluorophenyl)-3-methylimidazo[4,5-b]pyridin-2-one
Show/Hide
|
C18H20FN3O
|
1
|
| 1 |
EC50 = 81 nM
|
|
|
|
CP0074742
|
3-{(5S)-5-[(4-tert-butylphenoxy)methyl]-2-oxo-1,3-oxazolidin-3-yl}benzonitrile
Show/Hide
|
C21H22N2O3
|
2
|
| 1 |
EC50 = 82 nM
|
|
|
| 2 |
EC50 = 4900 nM
|
|
|
|
CP0376956
|
CHEMBL3940264
Show/Hide
|
C24H25F5N4
|
1
|
| 1 |
EC50 = 83 nM
|
|
|
|
CP0413660
|
8-chloro-7-(7-chloro-1H-indol-5-yl)-3-(2,2,2-trifluoroethyl)imidazo[1,2-a]pyridine
Show/Hide
|
C17H10Cl2F3N3
|
1
|
| 1 |
EC50 = 85 nM
|
|
|
|
CP0181913
|
1-(2,2-dimethylpropyl)-5-[5-(hydroxymethyl)-2-methylphenyl]-3-methylimidazo[4,5-b]pyridin-2-one
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C20H25N3O2
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1
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| 1 |
EC50 = 86 nM
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CP0463607
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1-(cyclopropylmethyl)-4-[4-(4-fluorophenyl)piperidin-1-yl]-2-oxopyridine-3-carbonitrile
Show/Hide
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C21H22FN3O
|
1
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| 1 |
EC50 = 89 nM
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CP0463580
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1-butyl-2-oxo-4-(4-phenylpiperidin-1-yl)pyridine-3-carbonitrile
Show/Hide
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C21H25N3O
|
1
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| 1 |
EC50 = 95 nM
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CP0539109
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1-(cyclopropylmethyl)-4-[4-(4-methoxyphenyl)piperidin-1-yl]-2-oxopyridine-3-carbonitrile
Show/Hide
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C22H25N3O2
|
1
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| 1 |
EC50 = 98 nM
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CP0422137
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2-[[4-(3-chlorophenyl)piperidin-1-yl]methyl]-1-methylbenzimidazole
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C20H22ClN3
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2
|
| 1 |
EC50 = 100 nM
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| 2 |
EC50 = 3981.07 nM
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CP0422141
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1-methyl-2-((4-(4-(trifluoromethyl)phenyl)piperidin-1-yl)methyl)-1H-benzo[d]imidazole
Show/Hide
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C21H22F3N3
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2
|
| 1 |
EC50 = 100 nM
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| 2 |
EC50 = 1995.26 nM
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CP0513314
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1-methyl-2-[[4-[3-(trifluoromethyl)phenyl]piperidin-1-yl]methyl]benzimidazole
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C21H22F3N3
|
2
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| 1 |
EC50 = 100 nM
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| 2 |
EC50 = 2511.89 nM
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CP0420795
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1-butyl-4-[3-chloro-4-(2-methylpyridin-3-yl)oxyphenyl]-2-oxopyridine-3-carbonitrile
Show/Hide
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C22H20ClN3O2
|
1
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| 1 |
EC50 = 100 nM
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CP0432221
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4-(3-chloro-4-cyclopentyloxyphenyl)-1-(3-methylbutyl)-2-oxopyridine-3-carbonitrile
Show/Hide
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C22H25ClN2O2
|
1
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| 1 |
EC50 = 100 nM
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CP0450656
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4-[4-(2,6-dimethylpyridin-3-yl)oxyphenyl]-1-(3-methylbutyl)-2-oxopyridine-3-carbonitrile
Show/Hide
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C24H25N3O2
|
1
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| 1 |
EC50 = 100 nM
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CP0413719
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8-chloro-3-(cyclopropylmethyl)-7-(4-phenylpiperidin-1-yl)-[1,2,4]triazolo[4,3-a]pyridine
Show/Hide
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C21H23ClN4
|
1
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| 1 |
EC50 = 102 nM
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CP0511002
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1-(3-methylbutyl)-2-oxo-4-(4-phenylpiperidin-1-yl)pyridine-3-carbonitrile
Show/Hide
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C22H27N3O
|
1
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| 1 |
EC50 = 102 nM
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CP0509262
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1-(2,2-dimethylpropyl)-3-methyl-5-(3-methylphenyl)imidazo[4,5-b]pyridin-2-one
Show/Hide
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C19H23N3O
|
1
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| 1 |
EC50 = 103 nM
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CP0436450
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4-[3-chloro-4-(cyclopropylmethoxy)phenyl]-1-(3-methylbutyl)-2-oxopyridine-3-carbonitrile
Show/Hide
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C21H23ClN2O2
|
1
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| 1 |
EC50 = 110 nM
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CP0435590
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7-[7-chloro-1-(cyclopropylmethyl)indol-5-yl]-3-(2,2,2-trifluoroethyl)imidazo[1,2-a]pyridine-8-carbonitrile
Show/Hide
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C22H16ClF3N4
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1
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| 1 |
EC50 = 110 nM
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CP0468145
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1-(2,2-dimethylpropyl)-5-[3-(hydroxymethyl)phenyl]-3-methylimidazo[4,5-b]pyridin-2-one
Show/Hide
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C19H23N3O2
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1
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| 1 |
EC50 = 112 nM
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CP0443445
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1-(2,2-dimethylpropyl)-3-methyl-5-[5-(pyridine-3-carbonyl)-2,5-diazabicyclo[2.2.2]octan-2-yl]imidazo[4,5-b]pyridin-2-one
Show/Hide
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C24H30N6O2
|
1
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| 1 |
EC50 = 115 nM
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CP0397529
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3-ethyl-7-(4-phenylpiperidin-1-yl)-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine
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C20H21F3N4
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1
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| 1 |
EC50 = 116 nM
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CP0412873
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8-chloro-7-(4-fluoro-4-phenylpiperidin-1-yl)-3-(2,2,2-trifluoroethyl)-[1,2,4]triazolo[4,3-a]pyridine
Show/Hide
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C19H17ClF4N4
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1
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| 1 |
EC50 = 116 nM
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CP0514518
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7-(7-chloro-1-methylindol-5-yl)-3-(2,2,2-trifluoroethyl)imidazo[1,2-a]pyridine-8-carbonitrile
Show/Hide
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C19H12ClF3N4
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1
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| 1 |
EC50 = 120 nM
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CP0445532
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7-(4-phenylpiperidin-1-yl)-3-(2,2,2-trifluoroethyl)imidazo[1,2-a]pyridine-8-carbonitrile
Show/Hide
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C21H19F3N4
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1
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| 1 |
EC50 = 125 nM
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CP0055055
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tert-butyl 5-[1-(2,2-dimethylpropyl)-3-methyl-2-oxoimidazo[4,5-b]pyridin-5-yl]-2,5-diazabicyclo[2.2.2]octane-2-carboxylate
Show/Hide
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C23H35N5O3
|
1
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| 1 |
EC50 = 125 nM
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CP0136531
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2-[[4-(5-chloropyrimidin-2-yl)piperazin-1-yl]methyl]-1-methylbenzimidazole
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C17H19ClN6
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2
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| 1 |
EC50 = 125.89 nM
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| 2 |
EC50 = 1258.93 nM
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CP0306761
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2-((4-(2-Fluorophenyl)piperidin-1-yl)methyl)-1-methyl-1H-benzo-[d]imidazole
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C20H22FN3
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2
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| 1 |
EC50 = 125.89 nM
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| 2 |
EC50 = 3981.07 nM
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CP0458982
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2-[[4-(4-chloro-2-fluorophenyl)piperazin-1-yl]methyl]-1-methylbenzimidazole
Show/Hide
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C19H20ClFN4
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2
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| 1 |
EC50 = 125.89 nM
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| 2 |
EC50 = 2511.89 nM
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CP0458994
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2-[[4-[6-chloro-3-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]methyl]-6-fluoro-1-methylbenzimidazole
Show/Hide
|
C19H18ClF4N5
|
1
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| 1 |
EC50 = 125.89 nM
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CP0506246
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1-benzyl-2-[[4-(5-chloropyrimidin-2-yl)piperazin-1-yl]methyl]benzimidazole
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C23H23ClN6
|
1
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| 1 |
EC50 = 125.89 nM
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CP0541683
|
1-benzyl-2-[[4-[6-chloro-3-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]methyl]benzimidazole
Show/Hide
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C25H23ClF3N5
|
1
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| 1 |
EC50 = 125.89 nM
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CP0867333
|
5-(2-Methoxyphenethylamino)-2-propylisoquinolin-1(2H)-one
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C21H24N2O2
|
1
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| 1 |
EC50 = 125.89 nM
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CP0432338
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1-(cyclobutylmethyl)-4-[4-(2-methylpyridin-4-yl)oxyphenyl]-2-oxopyridine-3-carbonitrile
Show/Hide
|
C23H21N3O2
|
1
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| 1 |
EC50 = 126 nM
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CP0427819
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3-(cyclopropylmethyl)-7-[(4-fluoro-4-phenylpiperidin-1-yl)methyl]-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine
Show/Hide
|
C23H24F4N4
|
1
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| 1 |
EC50 = 132 nM
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CP0432337
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1-butyl-4-[4-(2,6-dimethylpyridin-3-yl)oxyphenyl]-2-oxopyridine-3-carbonitrile
Show/Hide
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C23H23N3O2
|
1
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| 1 |
EC50 = 138 nM
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CP0533046
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1-(cyclopropylmethyl)-4-[4-(3-fluorophenyl)piperidin-1-yl]-2-oxopyridine-3-carbonitrile
Show/Hide
|
C21H22FN3O
|
1
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| 1 |
EC50 = 141 nM
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CP0494411
|
7-[3-chloro-4-(cyclopropylamino)phenyl]-3-(2,2,2-trifluoroethyl)imidazo[1,2-a]pyridine-8-carbonitrile
Show/Hide
|
C19H14ClF3N4
|
1
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| 1 |
EC50 = 141.25 nM
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CP0054727
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1-butyl-3-chloro-4-(4-phenylpiperidin-1-yl)pyridin-2-one
Show/Hide
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C20H25ClN2O
|
2
|
| 1 |
EC50 = 147 nM
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| 2 |
IC50 = 68 nM
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CP0413717
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2-[3-(cyclopropylmethyl)-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridin-7-yl]-3,4-dihydro-1H-isoquinoline
Show/Hide
|
C20H19F3N4
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1
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| 1 |
EC50 = 149 nM
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CP0383130
|
1-(2,2-dimethylpropyl)-3-methyl-5-[5-[(5-methyl-1,2-oxazol-3-yl)methyl]-2,5-diazabicyclo[2.2.2]octan-2-yl]imidazo[4,5-b]pyridin-2-one
Show/Hide
|
C23H32N6O2
|
1
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| 1 |
EC50 = 149 nM
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CP0493994
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4-[2-chloro-4-[8-chloro-3-(2,2,2-trifluoroethyl)imidazo[1,2-a]pyridin-7-yl]anilino]cyclohexan-1-ol
Show/Hide
|
C21H20Cl2F3N3O
|
1
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| 1 |
EC50 = 150 nM
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CP0417653
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1-(cyclopropylmethyl)-2-oxo-4-(4-phenylpiperidin-1-yl)pyridine-3-carbonitrile
Show/Hide
|
C21H23N3O
|
1
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| 1 |
EC50 = 151 nM
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CP0463608
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1-(cyclopropylmethyl)-4-[4-(3,5-difluorophenyl)piperidin-1-yl]-2-oxopyridine-3-carbonitrile
Show/Hide
|
C21H21F2N3O
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1
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| 1 |
EC50 = 151 nM
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CP0412875
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7-(4-phenylpiperidin-1-yl)-3-propylimidazo[1,2-a]pyridine-8-carbonitrile
Show/Hide
|
C22H24N4
|
1
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| 1 |
EC50 = 155 nM
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CP0507280
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7-(4-phenylmethoxyphenyl)-3-(2,2,2-trifluoroethyl)imidazo[1,2-a]pyridine-8-carbonitrile
Show/Hide
|
C23H16F3N3O
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1
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| 1 |
EC50 = 158.49 nM
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CP0387456
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2-[1-[(1-methylbenzimidazol-2-yl)methyl]piperidin-4-yl]-1,3-benzothiazole
Show/Hide
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C21H22N4S
|
2
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| 1 |
EC50 = 158.49 nM
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| 2 |
EC50 = 3162.28 nM
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CP0506247
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2-[[4-[6-chloro-3-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]methyl]-1-(2-methoxyethyl)benzimidazole
Show/Hide
|
C21H23ClF3N5O
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1
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| 1 |
EC50 = 158.49 nM
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CP0513957
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2-[[4-(5-chloropyrimidin-2-yl)piperazin-1-yl]methyl]-1-ethylbenzimidazole
Show/Hide
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C18H21ClN6
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1
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| 1 |
EC50 = 158.49 nM
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CP0376931
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8-chloro-2-propyl-6-(4-pyridin-4-yloxyphenyl)isoquinolin-1-one
Show/Hide
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C23H19ClN2O2
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1
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| 1 |
EC50 = 158.49 nM
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CP0880217
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5-(3-Phenylpropylamino)-2-propylisoquinolin-1(2H)-one
Show/Hide
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C21H24N2O
|
1
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| 1 |
EC50 = 158.49 nM
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CP0446028
|
CHEMBL2152119
Show/Hide
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C23H21ClF3N3O
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1
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| 1 |
EC50 = 160 nM
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CP0410294
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1-butyl-4-[3-chloro-4-(2-methylpyridin-4-yl)oxyphenyl]-2-oxopyridine-3-carbonitrile
Show/Hide
|
C22H20ClN3O2
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1
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| 1 |
EC50 = 166 nM
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CP0463599
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3-chloro-1-(cyclopropylmethyl)-4-(4-phenylpiperidin-1-yl)pyridin-2-one
Show/Hide
|
C20H23ClN2O
|
1
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| 1 |
EC50 = 170 nM
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CP0420792
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4-[3-chloro-4-(oxan-4-ylamino)phenyl]-1-(3-methylbutyl)-2-oxopyridine-3-carbonitrile
Show/Hide
|
C22H26ClN3O2
|
1
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| 1 |
EC50 = 174 nM
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CP0445531
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8-chloro-3-(cyclopropylmethyl)-7-[4-phenyl-4-(trifluoromethyl)piperidin-1-yl]-[1,2,4]triazolo[4,3-a]pyridine
Show/Hide
|
C22H22ClF3N4
|
1
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| 1 |
EC50 = 178 nM
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CP0398769
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1-(2-cyclopropylethyl)-2-oxo-4-(4-phenylpiperidin-1-yl)pyridine-3-carbonitrile
Show/Hide
|
C22H25N3O
|
1
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| 1 |
EC50 = 178 nM
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CP0566649
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1-(2,2-dimethylpropyl)-5-[4-(hydroxymethyl)phenyl]-3-methylimidazo[4,5-b]pyridin-2-one
Show/Hide
|
C19H23N3O2
|
1
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| 1 |
EC50 = 181 nM
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CP0385039
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1-(2,2-dimethylpropyl)-5-(2-methoxyphenyl)-3-methylimidazo[4,5-b]pyridin-2-one
Show/Hide
|
C19H23N3O2
|
1
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| 1 |
EC50 = 184 nM
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CP0523108
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4-[3-chloro-4-(oxan-4-yloxy)phenyl]-1-(3-methylbutyl)-2-oxopyridine-3-carbonitrile
Show/Hide
|
C22H25ClN2O3
|
1
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| 1 |
EC50 = 186 nM
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CP0446540
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7-(4-phenoxyphenyl)-3-(2,2,2-trifluoroethyl)imidazo[1,2-a]pyridine-8-carbonitrile
Show/Hide
|
C22H14F3N3O
|
2
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| 1 |
EC50 = 186 nM
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| 2 |
EC50 = 186.21 nM
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CP0514517
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7-[1-(cyclopropylmethyl)indol-5-yl]-3-(2,2,2-trifluoroethyl)imidazo[1,2-a]pyridine-8-carbonitrile
Show/Hide
|
C22H17F3N4
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1
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| 1 |
EC50 = 190 nM
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CP0385038
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1-(2,2-dimethylpropyl)-3-methyl-5-(3-methylsulfonylphenyl)imidazo[4,5-b]pyridin-2-one
Show/Hide
|
C19H23N3O3S
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1
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| 1 |
EC50 = 191 nM
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CP0420569
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4-[1-(2,2-dimethylpropyl)-3-methyl-2-oxoimidazo[4,5-b]pyridin-5-yl]benzonitrile
Show/Hide
|
C19H20N4O
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1
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| 1 |
EC50 = 192 nM
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CP0533047
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3-chloro-1-(2-methylpropyl)-4-(4-phenylpiperidin-1-yl)pyridin-2-one
Show/Hide
|
C20H25ClN2O
|
1
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| 1 |
EC50 = 195 nM
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CP0158029
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7-methyl-5-[3-(piperazin-1-ylmethyl)-1,2,4-oxadiazol-5-yl]-2-[[4-(trifluoromethoxy)phenyl]methyl]-3H-isoindol-1-one
Show/Hide
|
C24H24F3N5O3
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1
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| 1 |
EC50 = 195 nM
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CP0441267
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1-Methyl-2-((4-phenylpiperidin-1-yl)methyl)-1H-benzo[d]-imidazole
Show/Hide
|
C20H23N3
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2
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| 1 |
EC50 = 199.53 nM
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| 2 |
EC50 = 6309.57 nM
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CP0452269
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1-methyl-2-[[4-[4-(trifluoromethyl)phenyl]piperazin-1-yl]methyl]benzimidazole
Show/Hide
|
C20H21F3N4
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2
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| 1 |
EC50 = 199.53 nM
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| 2 |
EC50 = 6309.57 nM
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CP0469995
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3-[1-[(1-methylbenzimidazol-2-yl)methyl]piperidin-4-yl]-1,2-benzothiazole
Show/Hide
|
C21H22N4S
|
2
|
| 1 |
EC50 = 199.53 nM
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| 2 |
EC50 = 2511.89 nM
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CP0473909
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2-[[4-[6-chloro-3-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]methyl]-5-fluoro-1-methylbenzimidazole
Show/Hide
|
C19H18ClF4N5
|
1
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| 1 |
EC50 = 199.53 nM
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CP0856503
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2-Propyl-5-(3-trifluoromethoxybenzylamino)isoquinolin-1(2H)-one
Show/Hide
|
C20H19F3N2O2
|
1
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| 1 |
EC50 = 199.53 nM
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CP0867334
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5-(2-Chlorobenzylamino)-2-propylisoquinolin-1(2H)-one
Show/Hide
|
C19H19ClN2O
|
1
|
| 1 |
EC50 = 199.53 nM
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CP0867335
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5-(4-Methylphenethylamino)-2-propylisoquinolin-1(2H)-one
Show/Hide
|
C21H24N2O
|
1
|
| 1 |
EC50 = 199.53 nM
|
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CP0436453
|
4-[3-chloro-4-(2-methylpyridin-3-yl)oxyphenyl]-1-(cyclopropylmethyl)-2-oxopyridine-3-carbonitrile
Show/Hide
|
C22H18ClN3O2
|
1
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| 1 |
EC50 = 230 nM
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CP0514516
|
7-(1-methylindol-5-yl)-3-(2,2,2-trifluoroethyl)imidazo[1,2-a]pyridine-8-carbonitrile
Show/Hide
|
C19H13F3N4
|
1
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| 1 |
EC50 = 230 nM
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CP0492827
|
7-(4-piperidin-1-ylphenyl)-3-(2,2,2-trifluoroethyl)imidazo[1,2-a]pyridine-8-carbonitrile
Show/Hide
|
C21H19F3N4
|
1
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| 1 |
EC50 = 234.42 nM
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CP0400700
|
5-[(4-tert-butylphenoxy)methyl]-3-phenyl-1,3-oxazolidin-2-one
Show/Hide
|
C20H23NO3
|
1
|
| 1 |
EC50 = 240 nM
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CP0386446
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3-(5-hexyl-2-oxo-1,3-oxazolidin-3-yl)benzonitrile
Show/Hide
|
C16H20N2O2
|
1
|
| 1 |
EC50 = 250 nM
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CP0531816
|
8-chloro-7-[7-chloro-1-(cyclopropylmethyl)indol-5-yl]-3-(2,2,2-trifluoroethyl)imidazo[1,2-a]pyridine
Show/Hide
|
C21H16Cl2F3N3
|
1
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| 1 |
EC50 = 250 nM
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CP0510999
|
1-(cyclopropylmethyl)-4-(4-phenylpiperidin-1-yl)-3-(trifluoromethyl)pyridin-2-one
Show/Hide
|
C21H23F3N2O
|
1
|
| 1 |
EC50 = 251 nM
|
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CP0475099
|
2-[[4-[6-chloro-3-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]methyl]-5-methoxy-1-methylbenzimidazole
Show/Hide
|
C20H21ClF3N5O
|
1
|
| 1 |
EC50 = 251.19 nM
|
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CP0404332
|
8-chloro-2-propyl-6-[4-[[6-(trifluoromethyl)pyridin-3-yl]methoxy]phenyl]isoquinolin-1-one
Show/Hide
|
C25H20ClF3N2O2
|
1
|
| 1 |
EC50 = 251.19 nM
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CP0877430
|
5-(4-Methoxyphenethoxy)2-propylisoquinolin-1(2H)-one
Show/Hide
|
C21H23NO3
|
1
|
| 1 |
EC50 = 251.19 nM
|
|
|
|
CP0923532
|
5-(3-Methoxyphenethylamino)-2-propylisoquinolin-1(2H)-one
Show/Hide
|
C21H24N2O2
|
1
|
| 1 |
EC50 = 251.19 nM
|
|
|
|
CP0949399
|
5-(chloro(phenethyl)amino)-2-propylisoquinolin-1(2H)-one
Show/Hide
|
C20H21ClN2O
|
1
|
| 1 |
EC50 = 251.19 nM
|
|
|
|
CP0949400
|
5-(4-Methoxyphenethylamino)-2-propylisoquinolin-1(2H)-one
Show/Hide
|
C21H24N2O2
|
1
|
| 1 |
EC50 = 251.19 nM
|
|
|
|
CP0415973
|
4-(3,4-dimethoxyphenyl)-1-(3-methylbutyl)-2-oxopyridine-3-carbonitrile
Show/Hide
|
C19H22N2O3
|
1
|
| 1 |
EC50 = 260 nM
|
|
|
|
CP0523107
|
1-(cyclopropylmethyl)-4-[4-(2,6-dimethylpyridin-3-yl)oxyphenyl]-2-oxopyridine-3-carbonitrile
Show/Hide
|
C23H21N3O2
|
1
|
| 1 |
EC50 = 263 nM
|
|
|
|
CP0450654
|
1-(3-methylbutyl)-4-[4-(2-methylpyridin-3-yl)oxyphenyl]-2-oxopyridine-3-carbonitrile
Show/Hide
|
C23H23N3O2
|
1
|
| 1 |
EC50 = 275 nM
|
|
|
|
CP0524144
|
1-(2-methylpropyl)-2-oxo-4-(4-phenylpiperidin-1-yl)pyridine-3-carbonitrile
Show/Hide
|
C21H25N3O
|
1
|
| 1 |
EC50 = 282 nM
|
|
|
|
CP0450649
|
4-[4-(cyclopropylmethoxy)phenyl]-1-(3-methylbutyl)-2-oxopyridine-3-carbonitrile
Show/Hide
|
C21H24N2O2
|
1
|
| 1 |
EC50 = 290 nM
|
|
|
|
CP0430433
|
7-(4-phenylpiperidin-1-yl)-3-propyl-[1,2,4]triazolo[4,3-a]pyridine-8-carbonitrile
Show/Hide
|
C21H23N5
|
1
|
| 1 |
EC50 = 299 nM
|
|
|
|
CP0538613
|
1-(2,2-dimethylpropyl)-3-methyl-5-(4-methylphenyl)imidazo[4,5-b]pyridin-2-one
Show/Hide
|
C19H23N3O
|
1
|
| 1 |
EC50 = 313 nM
|
|
|
|
CP0293940
|
1-butyl-4-[3-fluoro-4-(2-methylpyridin-4-yl)oxyphenyl]-2-oxopyridine-3-carbonitrile
Show/Hide
|
C22H20FN3O2
|
1
|
| 1 |
EC50 = 316 nM
|
|
|
|
CP0422140
|
1-methyl-2-((4-(2-(trifluoromethyl)phenyl)piperidin-1-yl)methyl)-1H-benzo[d]imidazole
Show/Hide
|
C21H22F3N3
|
2
|
| 1 |
EC50 = 316.23 nM
|
|
|
| 2 |
EC50 = 6309.57 nM
|
|
|
|
CP0452272
|
2-[4-[(1-methylbenzimidazol-2-yl)methyl]piperazin-1-yl]-1,3-benzothiazole
Show/Hide
|
C20H21N5S
|
2
|
| 1 |
EC50 = 316.23 nM
|
|
|
| 2 |
EC50 = 1995.26 nM
|
|
|
|
CP0473888
|
1-methyl-2-[[4-[2-(trifluoromethyl)phenyl]piperazin-1-yl]methyl]benzimidazole
Show/Hide
|
C20H21F3N4
|
2
|
| 1 |
EC50 = 316.23 nM
|
|
|
| 2 |
EC50 > 15848.93 nM
|
|
|
|
CP0376930
|
8-chloro-2-propyl-6-[6-(pyridin-3-ylmethoxy)pyridin-3-yl]isoquinolin-1-one
Show/Hide
|
C23H20ClN3O2
|
1
|
| 1 |
EC50 = 316.23 nM
|
|
|
|
CP0542084
|
8-chloro-6-(4-methoxyphenyl)-2-propylisoquinolin-1-one
Show/Hide
|
C19H18ClNO2
|
1
|
| 1 |
EC50 = 316.23 nM
|
|
|
|
CP0900303
|
5-(3-Methoxybenzylamino)-2-propylisoquinolin-1(2H)-one
Show/Hide
|
C20H22N2O2
|
1
|
| 1 |
EC50 = 316.23 nM
|
|
|
|
CP0486091
|
7-(7-chloro-1H-indol-5-yl)-3-(2,2,2-trifluoroethyl)imidazo[1,2-a]pyridine-8-carbonitrile
Show/Hide
|
C18H10ClF3N4
|
1
|
| 1 |
EC50 = 320 nM
|
|
|
|
CP0486088
|
7-[1-(4-hydroxycyclohexyl)indol-5-yl]-3-(2,2,2-trifluoroethyl)imidazo[1,2-a]pyridine-8-carbonitrile
Show/Hide
|
C24H21F3N4O
|
1
|
| 1 |
EC50 = 330 nM
|
|
|
|
CP0055051
|
5-(3,4-dihydro-2H-quinolin-1-yl)-1-(2,2-dimethylpropyl)-3-methylimidazo[4,5-b]pyridin-2-one
Show/Hide
|
C21H26N4O
|
1
|
| 1 |
EC50 = 332 nM
|
|
|
|
CP0420794
|
1-butyl-4-[4-(2-methylpyridin-3-yl)oxyphenyl]-2-oxopyridine-3-carbonitrile
Show/Hide
|
C22H21N3O2
|
1
|
| 1 |
EC50 = 347 nM
|
|
|
|
CP0506508
|
5-((3-tert-butylphenoxy)methyl)-3-phenyloxazolidin-2-one
Show/Hide
|
C20H23NO3
|
1
|
| 1 |
EC50 = 350 nM
|
|
|
|
CP0533054
|
2-oxo-4-(4-phenylpiperidin-1-yl)-1-(4,4,4-trifluorobutyl)pyridine-3-carbonitrile
Show/Hide
|
C21H22F3N3O
|
1
|
| 1 |
EC50 = 355 nM
|
|
|
|
CP0390532
|
5-((4-chlorophenoxy)methyl)-3-phenyloxazolidin-2-one
Show/Hide
|
C16H14ClNO3
|
1
|
| 1 |
EC50 = 360 nM
|
|
|
|
CP0401445
|
5-((4-isopropylphenoxy)methyl)-3-phenyloxazolidin-2-one
Show/Hide
|
C19H21NO3
|
1
|
| 1 |
EC50 = 360 nM
|
|
|
|
CP0475410
|
5-((3-ethylphenoxy)methyl)-3-phenyloxazolidin-2-one
Show/Hide
|
C18H19NO3
|
1
|
| 1 |
EC50 = 360 nM
|
|
|
|
CP0511001
|
1-(3-methylbutyl)-2-oxo-4-(2-phenylethyl)pyridine-3-carbonitrile
Show/Hide
|
C19H22N2O
|
1
|
| 1 |
EC50 = 361 nM
|
|
|
|
CP0450648
|
4-(3-chloro-4-methoxyphenyl)-1-(3-methylbutyl)-2-oxopyridine-3-carbonitrile
Show/Hide
|
C18H19ClN2O2
|
1
|
| 1 |
EC50 = 363 nM
|
|
|
|
CP0515481
|
1-butyl-4-[4-(2,6-dimethylpyridin-4-yl)oxy-3-fluorophenyl]-2-oxopyridine-3-carbonitrile
Show/Hide
|
C23H22FN3O2
|
1
|
| 1 |
EC50 = 372 nM
|
|
|
|
CP0536391
|
1-(2,2-dimethylpropyl)-3-methyl-5-(4-methylsulfonylphenyl)imidazo[4,5-b]pyridin-2-one
Show/Hide
|
C19H23N3O3S
|
1
|
| 1 |
EC50 = 379 nM
|
|
|
|
CP0397530
|
8-chloro-3-ethyl-7-(4-phenylpiperidin-1-yl)-[1,2,4]triazolo[4,3-a]pyridine
Show/Hide
|
C19H21ClN4
|
1
|
| 1 |
EC50 = 386 nM
|
|
|
|
CP0494809
|
1-butyl-4-[2-fluoro-4-(2-methylpyridin-4-yl)oxyphenyl]-2-oxopyridine-3-carbonitrile
Show/Hide
|
C22H20FN3O2
|
1
|
| 1 |
EC50 = 390 nM
|
|
|
|
CP0410293
|
1-butyl-4-[4-(2-methylpyridin-4-yl)oxyphenyl]-2-oxopyridine-3-carbonitrile
Show/Hide
|
C22H21N3O2
|
1
|
| 1 |
EC50 = 398 nM
|
|
|
|
CP0469054
|
8-chloro-6-(5-fluoro-6-methoxypyridin-3-yl)-2-propylisoquinolin-1-one
Show/Hide
|
C18H16ClFN2O2
|
1
|
| 1 |
EC50 = 398.11 nM
|
|
|
|
CP0475859
|
8-chloro-6-[4-[(6-chloropyridin-3-yl)methoxy]phenyl]-2-propylisoquinolin-1-one
Show/Hide
|
C24H20Cl2N2O2
|
1
|
| 1 |
EC50 = 398.11 nM
|
|
|
|
CP0867336
|
5-[N-(4-Methoxyphenethyl)-N-methylamino]-2-propylisoquinolin-1(2H)-one
Show/Hide
|
C22H26N2O2
|
1
|
| 1 |
EC50 = 398.11 nM
|
|
|
|
CP0479528
|
3-(cyclopropylmethyl)-7-(1,3-dihydroisoindol-2-yl)-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine
Show/Hide
|
C19H17F3N4
|
1
|
| 1 |
EC50 = 400 nM
|
|
|
|
CP0047321
|
1-(2,2-dimethylpropyl)-3-methyl-5-piperidin-1-ylimidazo[4,5-b]pyridin-2-one
Show/Hide
|
C17H26N4O
|
1
|
| 1 |
EC50 = 430 nM
|
|
|
|
CP0480131
|
7-[4-(4,6-dimethylpyrimidin-2-yl)piperazin-1-yl]-3-(2,2,2-trifluoroethyl)imidazo[1,2-a]pyridine-8-carbonitrile
Show/Hide
|
C20H20F3N7
|
1
|
| 1 |
EC50 = 446.68 nM
|
|
|
|
CP0502269
|
7-(4-tert-butylphenyl)-3-(2,2,2-trifluoroethyl)imidazo[1,2-a]pyridine-8-carbonitrile
Show/Hide
|
C20H18F3N3
|
1
|
| 1 |
EC50 = 446.68 nM
|
|
|
|
CP0065879
|
1-(3-methylbutyl)-4-[4-(2-methylpyridin-4-yl)oxyphenyl]-2-oxopyridine-3-carbonitrile
Show/Hide
|
C23H23N3O2
|
1
|
| 1 |
EC50 = 447 nM
|
|
|
|
CP0401446
|
(R)-5-hexyl-3-phenyloxazolidin-2-one
Show/Hide
|
C15H21NO2
|
2
|
| 1 |
EC50 = 450 nM
|
|
|
| 2 |
EC50 = 13800 nM
|
|
|
|
CP0436452
|
4-[4-(methylamino)phenyl]-1-(3-methylbutyl)-2-oxopyridine-3-carbonitrile
Show/Hide
|
C18H21N3O
|
1
|
| 1 |
EC50 = 460 nM
|
|
|
|
CP0413720
|
3-(methoxymethyl)-7-(4-phenylpiperidin-1-yl)-[1,2,4]triazolo[4,3-a]pyridine-8-carbonitrile
Show/Hide
|
C20H21N5O
|
1
|
| 1 |
EC50 = 468 nM
|
|
|
|
CP0385353
|
1-(3-methylbutyl)-2-oxo-4-(4-pyridin-3-yloxyphenyl)pyridine-3-carbonitrile
Show/Hide
|
C22H21N3O2
|
1
|
| 1 |
EC50 = 479 nM
|
|
|
|
CP0413659
|
7-[1-(oxan-4-yl)indol-5-yl]-3-(2,2,2-trifluoroethyl)imidazo[1,2-a]pyridine-8-carbonitrile
Show/Hide
|
C23H19F3N4O
|
1
|
| 1 |
EC50 = 501 nM
|
|
|
|
CP0534107
|
3-ethyl-7-(4-phenylpiperidin-1-yl)imidazo[1,2-a]pyridine-8-carbonitrile
Show/Hide
|
C21H22N4
|
1
|
| 1 |
EC50 = 501 nM
|
|
|
|
CP0387459
|
1-methyl-2-[[4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]methyl]benzimidazole
Show/Hide
|
C19H20F3N5
|
2
|
| 1 |
EC50 = 501.19 nM
|
|
|
| 2 |
EC50 = 6309.57 nM
|
|
|
|
CP0507289
|
2-[[4-(5-chloropyrimidin-2-yl)piperazin-1-yl]methyl]-1-(2-methoxyethyl)benzimidazole
Show/Hide
|
C19H23ClN6O
|
1
|
| 1 |
EC50 = 501.19 nM
|
|
|
|
CP0475860
|
8-chloro-6-(6-phenoxypyridin-3-yl)-2-propylisoquinolin-1-one
Show/Hide
|
C23H19ClN2O2
|
1
|
| 1 |
EC50 = 501.19 nM
|
|
|
|
CP0693205
|
5-Phenethylamino-2-propylisoquinolin-1(2H)-one
Show/Hide
|
C20H22N2O
|
1
|
| 1 |
EC50 = 501.19 nM
|
|
|
|
CP0856504
|
5-(chloro(3-methoxybenzyl)amino)-2-propylisoquinolin-1(2H)-one
Show/Hide
|
C20H21ClN2O2
|
1
|
| 1 |
EC50 = 501.19 nM
|
|
|
|
CP0949401
|
5-(4-Methoxybenzylamino)-2-propylisoquinolin-1(2H)-one
Show/Hide
|
C20H22N2O2
|
1
|
| 1 |
EC50 = 501.19 nM
|
|
|
|
CP0441018
|
3-(cyclopropylmethyl)-7-(4-pyridin-3-ylpiperidin-1-yl)-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine
Show/Hide
|
C21H22F3N5
|
1
|
| 1 |
EC50 = 519 nM
|
|
|
|
CP0443446
|
1-(2,2-dimethylpropyl)-3-methyl-5-[1-(1,2-oxazole-3-carbonyl)piperidin-4-yl]imidazo[4,5-b]pyridin-2-one
Show/Hide
|
C21H27N5O3
|
1
|
| 1 |
EC50 = 531 nM
|
|
|
|
CP0161011
|
1-(3-methylbutyl)-2-oxo-4-(4-pyridin-4-yloxyphenyl)pyridine-3-carbonitrile
Show/Hide
|
C22H21N3O2
|
1
|
| 1 |
EC50 = 550 nM
|
|
|
|
CP0452182
|
5-((3-isopropylphenoxy)methyl)-3-phenyloxazolidin-2-one
Show/Hide
|
C19H21NO3
|
1
|
| 1 |
EC50 = 580 nM
|
|
|
|
CP0383473
|
3-(3-chlorophenyl)-5-hexyloxazolidin-2-one
Show/Hide
|
C15H20ClNO2
|
1
|
| 1 |
EC50 = 590 nM
|
|
|
|
CP0452181
|
5-((4-ethylphenoxy)methyl)-3-phenyloxazolidin-2-one
Show/Hide
|
C18H19NO3
|
1
|
| 1 |
EC50 = 590 nM
|
|
|
|
CP0851238
|
5-hexyl-3-phenyloxazolidin-2-one
Show/Hide
|
C15H21NO2
|
1
|
| 1 |
EC50 = 590 nM
|
|
|
|
CP0531815
|
7-[3-chloro-4-(oxan-4-yloxy)phenyl]-3-(2,2,2-trifluoroethyl)imidazo[1,2-a]pyridine-8-carbonitrile
Show/Hide
|
C21H17ClF3N3O2
|
1
|
| 1 |
EC50 = 617 nM
|
|
|
|
CP0446538
|
1-butyl-4-[4-(4,6-dimethylpyrimidin-2-yl)piperazin-1-yl]-2-oxopyridine-3-carbonitrile
Show/Hide
|
C20H26N6O
|
1
|
| 1 |
EC50 = 630.96 nM
|
|
|
|
CP0376929
|
8-chloro-6-[6-(2-phenylethoxy)pyridin-3-yl]-2-propylisoquinolin-1-one
Show/Hide
|
C25H23ClN2O2
|
1
|
| 1 |
EC50 = 630.96 nM
|
|
|
|
CP0404330
|
8-chloro-2-propyl-6-(3-pyridin-3-ylpropoxy)isoquinolin-1-one
Show/Hide
|
C20H21ClN2O2
|
1
|
| 1 |
EC50 = 630.96 nM
|
|
|
|
CP0473360
|
8-chloro-2-propyl-6-pyridin-3-ylisoquinolin-1-one
Show/Hide
|
C17H15ClN2O
|
1
|
| 1 |
EC50 = 630.96 nM
|
|
|
|
CP0455525
|
5-hexyl-3-(3-methoxyphenyl)oxazolidin-2-one
Show/Hide
|
C16H23NO3
|
1
|
| 1 |
EC50 = 640 nM
|
|
|
|
CP0475405
|
5-hexyl-3-m-tolyloxazolidin-2-one
Show/Hide
|
C16H23NO2
|
1
|
| 1 |
EC50 = 640 nM
|
|
|
|
CP0503917
|
3-(3-fluorophenyl)-5-hexyloxazolidin-2-one
Show/Hide
|
C15H20FNO2
|
1
|
| 1 |
EC50 = 640 nM
|
|
|
|
CP0485954
|
7-[4-(4,6-dimethylpyrimidin-2-yl)piperazin-1-yl]-3-propylimidazo[1,2-a]pyridine-8-carbonitrile
Show/Hide
|
C21H25N7
|
1
|
| 1 |
EC50 = 645.65 nM
|
|
|
|
CP0436451
|
1-(3-methylbutyl)-2-oxo-4-(4-pyridin-2-yloxyphenyl)pyridine-3-carbonitrile
Show/Hide
|
C22H21N3O2
|
1
|
| 1 |
EC50 = 646 nM
|
|
|
|
CP0514133
|
3-phenyl-5-(p-tolyloxymethyl)oxazolidin-2-one
Show/Hide
|
C17H17NO3
|
1
|
| 1 |
EC50 = 660 nM
|
|
|
|
CP0566918
|
1-(3-methylbutyl)-2-oxo-4-(4-phenylpiperazin-1-yl)pyridine-3-carbonitrile
Show/Hide
|
C21H26N4O
|
1
|
| 1 |
EC50 = 661 nM
|
|
|
|
CP0470443
|
3-ethyl-7-(4-phenylpiperidin-1-yl)-[1,2,4]triazolo[4,3-a]pyridine-8-carbonitrile
Show/Hide
|
C20H21N5
|
1
|
| 1 |
EC50 = 696 nM
|
|
|
|
CP0486089
|
7-[3-chloro-4-(oxan-4-ylamino)phenyl]-3-(2,2,2-trifluoroethyl)imidazo[1,2-a]pyridine-8-carbonitrile
Show/Hide
|
C21H18ClF3N4O
|
1
|
| 1 |
EC50 = 710 nM
|
|
|
|
CP0487684
|
4-(5-hexyl-2-oxooxazolidin-3-yl)benzonitrile
Show/Hide
|
C16H20N2O2
|
1
|
| 1 |
EC50 = 760 nM
|
|
|
|
CP0386449
|
3-phenyl-5-((4-(trifluoromethyl)phenoxy)methyl)oxazolidin-2-one
Show/Hide
|
C17H14F3NO3
|
1
|
| 1 |
EC50 = 780 nM
|
|
|
|
CP0475409
|
5-pentyl-3-phenyloxazolidin-2-one
Show/Hide
|
C14H19NO2
|
1
|
| 1 |
EC50 = 790 nM
|
|
|
|
CP0487678
|
3-(4-fluorophenyl)-5-hexyloxazolidin-2-one
Show/Hide
|
C15H20FNO2
|
1
|
| 1 |
EC50 = 790 nM
|
|
|
|
CP0387455
|
2-[[4-(5-chloropyrimidin-2-yl)piperazin-1-yl]methyl]-1-propylbenzimidazole
Show/Hide
|
C19H23ClN6
|
1
|
| 1 |
EC50 = 794.33 nM
|
|
|
|
CP0446516
|
2-[[4-(4-chlorophenyl)-1-piperazinyl]methyl]-1-methylbenzimidazole
Show/Hide
|
C19H21ClN4
|
2
|
| 1 |
EC50 = 794.33 nM
|
|
|
| 2 |
EC50 > 15848.93 nM
|
|
|
|
CP0458996
|
2-[[4-(2-fluorophenyl)piperazin-1-yl]methyl]-1-methylbenzimidazole
Show/Hide
|
C19H21FN4
|
2
|
| 1 |
EC50 = 794.33 nM
|
|
|
| 2 |
EC50 = 6309.57 nM
|
|
|
|
CP0380942
|
8-chloro-6-(6-methoxypyridin-3-yl)-2-propylisoquinolin-1-one
Show/Hide
|
C18H17ClN2O2
|
1
|
| 1 |
EC50 = 794.33 nM
|
|
|
|
CP0404331
|
8-chloro-6-(6-morpholin-4-ylpyridin-3-yl)-2-propylisoquinolin-1-one
Show/Hide
|
C21H22ClN3O2
|
1
|
| 1 |
EC50 = 794.33 nM
|
|
|
|
CP0499560
|
8-chloro-2-propyl-6-(2-pyridin-3-ylethoxy)isoquinolin-1-one
Show/Hide
|
C19H19ClN2O2
|
1
|
| 1 |
EC50 = 794.33 nM
|
|
|
|
CP0420793
|
1-(cyclopropylmethyl)-4-[4-(2-methylpyridin-4-yl)oxyphenyl]-2-oxopyridine-3-carbonitrile
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C22H19N3O2
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1
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| 1 |
EC50 = 832 nM
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CP0506509
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5-((3-chlorophenoxy)methyl)-3-phenyloxazolidin-2-one
Show/Hide
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C16H14ClNO3
|
1
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| 1 |
EC50 = 840 nM
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CP0459001
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7-(4-pyrimidin-2-ylpiperazin-1-yl)-3-(2,2,2-trifluoroethyl)imidazo[1,2-a]pyridine-8-carbonitrile
Show/Hide
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C18H16F3N7
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1
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| 1 |
EC50 = 851.14 nM
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CP0510980
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4-(3,4-dihydro-1H-isoquinolin-2-yl)-1-(3-methylbutyl)-2-oxopyridine-3-carbonitrile
Show/Hide
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C20H23N3O
|
1
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| 1 |
EC50 = 871 nM
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CP0542556
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1-butyl-4-[2-chloro-4-(2-methylpyridin-4-yl)oxyphenyl]-2-oxopyridine-3-carbonitrile
Show/Hide
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C22H20ClN3O2
|
1
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| 1 |
EC50 = 933 nM
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CP0445530
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8-chloro-3-(cyclopropylmethyl)-7-(4-phenylpiperazin-1-yl)-[1,2,4]triazolo[4,3-a]pyridine
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C20H22ClN5
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1
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| 1 |
EC50 = 944 nM
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CP0371726
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7-(4-phenylpiperazin-1-yl)-3-propylimidazo[1,2-a]pyridine-8-carbonitrile
Show/Hide
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C21H23N5
|
1
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| 1 |
EC50 = 977.24 nM
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CP0450655
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1-(cyclopropylmethyl)-4-[4-(2-methylpyridin-3-yl)oxyphenyl]-2-oxopyridine-3-carbonitrile
Show/Hide
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C22H19N3O2
|
1
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| 1 |
EC50 = 1072 nM
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CP0485952
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3-(2-cyclopropylethyl)-7-(4-pyrimidin-2-ylpiperazin-1-yl)imidazo[1,2-a]pyridine-8-carbonitrile
Show/Hide
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C21H23N7
|
1
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| 1 |
EC50 = 1096.48 nM
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CP0413714
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7-(4-phenylpiperidin-1-yl)-3-(pyrrolidin-1-ylmethyl)-[1,2,4]triazolo[4,3-a]pyridine-8-carbonitrile
Show/Hide
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C23H26N6
|
1
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| 1 |
EC50 = 1120 nM
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CP0514023
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4-(4-methoxyphenyl)-1-(3-methylbutyl)-2-oxopyridine-3-carbonitrile
Show/Hide
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C18H20N2O2
|
1
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| 1 |
EC50 = 1150 nM
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CP0386447
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5-hexyl-3-(4-methoxyphenyl)oxazolidin-2-one
Show/Hide
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C16H23NO3
|
1
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| 1 |
EC50 = 1170 nM
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CP0436449
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4-(3-fluoro-4-methoxyphenyl)-1-(3-methylbutyl)-2-oxopyridine-3-carbonitrile
Show/Hide
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C18H19FN2O2
|
1
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| 1 |
EC50 = 1170 nM
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CP0496165
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3-phenyl-5-((3-(trifluoromethyl)phenoxy)methyl)oxazolidin-2-one
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C17H14F3NO3
|
1
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| 1 |
EC50 = 1180 nM
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CP0514132
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5-octyl-3-phenyloxazolidin-2-one
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C17H25NO2
|
1
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| 1 |
EC50 = 1200 nM
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CP0496164
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methyl 4-(5-hexyl-2-oxo-1,3-oxazolidin-3-yl)benzoate
Show/Hide
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C17H23NO4
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1
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| 1 |
EC50 = 1220 nM
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CP0413716
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3-(cyclopropylmethyl)-7-(3-phenylpyrrolidin-1-yl)-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine
Show/Hide
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C21H21F3N4
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1
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| 1 |
EC50 = 1230 nM
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CP0499581
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3-tert-butyl-7-(4-phenylpiperidin-1-yl)-[1,2,4]triazolo[4,3-a]pyridine-8-carbonitrile
Show/Hide
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C22H25N5
|
1
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| 1 |
EC50 = 1230 nM
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CP0385927
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8-chloro-2-propyl-6-[4-(pyridin-3-ylmethoxy)phenyl]isoquinolin-1-one
Show/Hide
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C24H21ClN2O2
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1
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| 1 |
EC50 = 1258.93 nM
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CP0499557
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8-chloro-2-propyl-6-pyridin-4-ylisoquinolin-1-one
Show/Hide
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C17H15ClN2O
|
1
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| 1 |
EC50 = 1258.93 nM
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CP0900304
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5-(3-Phenoxybenzylamino)-2-propylisoquinolin-1(2H)-one
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C25H24N2O2
|
1
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| 1 |
EC50 = 1258.93 nM
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CP0047316
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5-(2,5-diazabicyclo[2.2.2]octan-2-yl)-1-(2,2-dimethylpropyl)-3-methylimidazo[4,5-b]pyridin-2-one
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C18H27N5O
|
1
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| 1 |
EC50 = 1286 nM
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CP0417984
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5-butyl-3-phenyloxazolidin-2-one
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C13H17NO2
|
1
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| 1 |
EC50 = 1300 nM
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CP0475408
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methyl 3-(5-hexyl-2-oxo-1,3-oxazolidin-3-yl)benzoate
Show/Hide
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C17H23NO4
|
1
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| 1 |
EC50 = 1350 nM
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CP0385354
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1-(3-methylbutyl)-2-oxo-4-[4-(pyridin-4-ylamino)phenyl]pyridine-3-carbonitrile
Show/Hide
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C22H22N4O
|
1
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| 1 |
EC50 = 1479 nM
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CP0469047
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8-chloro-2-propyl-6-(1H-pyrazol-4-yl)isoquinolin-1-one
Show/Hide
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C15H14ClN3O
|
1
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| 1 |
EC50 = 1584.89 nM
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CP0486090
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7-(3,4-dihydro-2H-1,4-benzoxazin-7-yl)-3-(2,2,2-trifluoroethyl)imidazo[1,2-a]pyridine-8-carbonitrile
Show/Hide
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C18H13F3N4O
|
1
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| 1 |
EC50 = 1660 nM
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CP0386445
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2-(5-hexyl-2-oxooxazolidin-3-yl)benzonitrile
Show/Hide
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C16H20N2O2
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1
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| 1 |
EC50 = 1760 nM
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CP0487685
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5-hexyl-3-(3-hydroxyphenyl)oxazolidin-2-one
Show/Hide
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C15H21NO3
|
1
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| 1 |
EC50 = 1930 nM
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CP0513313
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2-[[4-[6-chloro-3-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]methyl]-1-methyl-5-(trifluoromethyl)benzimidazole
Show/Hide
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C20H18ClF6N5
|
1
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| 1 |
EC50 = 1995.26 nM
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CP0446964
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8-chloro-6-(4-phenoxyphenyl)-2-propylisoquinolin-1-one
Show/Hide
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C24H20ClNO2
|
1
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| 1 |
EC50 = 1995.26 nM
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CP0867337
|
5-Benzylamino-2-propylisoquinolin-1(2H)-one
Show/Hide
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C19H20N2O
|
1
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| 1 |
EC50 = 1995.26 nM
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CP0450652
|
1-(3-methylbutyl)-4-(4-morpholin-4-ylphenyl)-2-oxopyridine-3-carbonitrile
Show/Hide
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C21H25N3O2
|
1
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| 1 |
EC50 = 2040 nM
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CP0514515
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7-(3-chloro-4-morpholin-4-ylphenyl)-3-(2,2,2-trifluoroethyl)imidazo[1,2-a]pyridine-8-carbonitrile
Show/Hide
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C20H16ClF3N4O
|
1
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| 1 |
EC50 = 2140 nM
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CP0514134
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5-((4-methoxyphenoxy)methyl)-3-phenyloxazolidin-2-one
Show/Hide
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C17H17NO4
|
1
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| 1 |
EC50 = 2190 nM
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CP0140518
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5-(3,4,4a,5,6,7,8,8a-octahydro-2H-quinolin-1-yl)-1-(2,2-dimethylpropyl)-3-methylimidazo[4,5-b]pyridin-2-one
Show/Hide
|
C21H32N4O
|
1
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| 1 |
EC50 = 2200 nM
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CP0421735
|
7-[4-(4,6-dimethylpyrimidin-2-yl)piperazin-1-yl]-3-ethylimidazo[1,2-a]pyridine-8-carbonitrile
Show/Hide
|
C20H23N7
|
1
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| 1 |
EC50 = 2290.87 nM
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CP0491214
|
2-[[4-[6-chloro-3-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]methyl]-1-propylbenzimidazole
Show/Hide
|
C21H23ClF3N5
|
1
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| 1 |
EC50 = 2511.89 nM
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CP0499559
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8-chloro-2-propyl-6-(pyridin-3-ylmethoxy)isoquinolin-1-one
Show/Hide
|
C18H17ClN2O2
|
1
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| 1 |
EC50 = 2511.89 nM
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CP0452180
|
5-hexyl-3-(3-(methylsulfonyl)phenyl)oxazolidin-2-one
Show/Hide
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C16H23NO4S
|
1
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| 1 |
EC50 = 2700 nM
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CP0483670
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1-(3-methylbutyl)-2-oxo-4-phenylmethoxypyridine-3-carbonitrile
Show/Hide
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C18H20N2O2
|
1
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| 1 |
EC50 = 2951 nM
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CP0481661
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1-(3-methylbutyl)-2-oxo-4-(4-pyridin-2-ylpiperazin-1-yl)pyridine-3-carbonitrile
Show/Hide
|
C20H25N5O
|
1
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| 1 |
EC50 = 3090 nM
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CP0469055
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8-chloro-2-propyl-6-(pyridin-3-ylmethylamino)isoquinolin-1-one
Show/Hide
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C18H18ClN3O
|
1
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| 1 |
EC50 = 3162.28 nM
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CP0436447
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4-(3-methoxyphenyl)-1-(3-methylbutyl)-2-oxopyridine-3-carbonitrile
Show/Hide
|
C18H20N2O2
|
1
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| 1 |
EC50 = 3169 nM
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CP0417983
|
3-(3-aminophenyl)-5-hexyloxazolidin-2-one
Show/Hide
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C15H22N2O2
|
1
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| 1 |
EC50 = 3300 nM
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CP0536845
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1-(3-methylbutyl)-2-oxo-4-(3-phenylpiperidin-1-yl)pyridine-3-carbonitrile
Show/Hide
|
C22H27N3O
|
1
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| 1 |
EC50 = 3311 nM
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CP0390533
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3-phenyl-5-(m-tolyloxymethyl)oxazolidin-2-one
Show/Hide
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C17H17NO3
|
1
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| 1 |
EC50 = 3440 nM
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CP0401444
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5-(phenoxymethyl)-3-phenyloxazolidin-2-one
Show/Hide
|
C16H15NO3
|
1
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| 1 |
EC50 = 3500 nM
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CP0383471
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5-hexyl-3-p-tolyloxazolidin-2-one
Show/Hide
|
C16H23NO2
|
1
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| 1 |
EC50 = 3820 nM
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CP0429987
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5-((2-chlorophenoxy)methyl)-3-phenyloxazolidin-2-one
Show/Hide
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C16H14ClNO3
|
1
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| 1 |
EC50 = 3897 nM
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CP0499558
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8-chloro-2-propyl-6-pyrimidin-5-ylisoquinolin-1-one
Show/Hide
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C16H14ClN3O
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1
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| 1 |
EC50 = 3981.07 nM
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CP0468677
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5-((3-methoxyphenoxy)methyl)-3-phenyloxazolidin-2-one
Show/Hide
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C17H17NO4
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1
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| 1 |
EC50 = 4110 nM
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CP0475407
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3-(4-chlorophenyl)-5-hexyloxazolidin-2-one
Show/Hide
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C15H20ClNO2
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1
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| 1 |
EC50 = 4450 nM
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CP0566650
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1-(2,2-dimethylpropyl)-3-methyl-5-(2-methylsulfonylphenyl)imidazo[4,5-b]pyridin-2-one
Show/Hide
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C19H23N3O3S
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1
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| 1 |
EC50 = 4624 nM
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CP0567248
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4-(4-benzylpiperazin-1-yl)-1-(3-methylbutyl)-2-oxopyridine-3-carbonitrile
Show/Hide
|
C22H28N4O
|
1
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| 1 |
EC50 = 4677 nM
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CP0387458
|
1-methyl-2-[(4-phenylpiperazin-1-yl)methyl]benzimidazole
Show/Hide
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C19H22N4
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2
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| 1 |
EC50 = 5011.87 nM
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| 2 |
EC50 > 15848.93 nM
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CP0380941
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8-chloro-6-[6-(dimethylamino)pyridin-3-yl]-2-propylisoquinolin-1-one
Show/Hide
|
C19H20ClN3O
|
1
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| 1 |
EC50 = 5011.87 nM
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CP0404329
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8-chloro-6-(4-hydroxypiperidin-1-yl)-2-propylisoquinolin-1-one
Show/Hide
|
C17H21ClN2O2
|
1
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| 1 |
EC50 = 5011.87 nM
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CP0438458
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8-chloro-6-morpholin-4-yl-2-propylisoquinolin-1-one
Show/Hide
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C16H19ClN2O2
|
1
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| 1 |
EC50 = 5011.87 nM
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CP0514131
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3-(4-aminophenyl)-5-hexyloxazolidin-2-one
Show/Hide
|
C15H22N2O2
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1
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| 1 |
EC50 = 5870 nM
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CP0475406
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3-(2-fluorophenyl)-5-hexyloxazolidin-2-one
Show/Hide
|
C15H20FNO2
|
1
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| 1 |
EC50 = 7150 nM
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CP0487686
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5-hexyl-3-(4-hydroxyphenyl)oxazolidin-2-one
Show/Hide
|
C15H21NO3
|
1
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| 1 |
EC50 = 7810 nM
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CP0499561
|
2-propyl-6-pyridin-3-ylisoquinolin-1-one
Show/Hide
|
C17H16N2O
|
1
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| 1 |
EC50 = 7943.28 nM
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CP0475287
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1-(3-methylbutyl)-2-oxo-4-phenylpyridine-3-carbonitrile
Show/Hide
|
C17H18N2O
|
1
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| 1 |
EC50 = 8510 nM
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CP0469046
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8-chloro-6-piperazin-1-yl-2-propylisoquinolin-1-one
Show/Hide
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C16H20ClN3O
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1
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| 1 |
EC50 > 10000 nM
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CP0505657
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6-morpholin-4-yl-2-propylisoquinolin-1-one
Show/Hide
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C16H20N2O2
|
1
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| 1 |
EC50 > 10000 nM
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CP0415972
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4-(2-methoxyphenyl)-1-(3-methylbutyl)-2-oxopyridine-3-carbonitrile
Show/Hide
|
C18H20N2O2
|
1
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| 1 |
EC50 > 10000 nM
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CP0524143
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4-[benzyl(methyl)amino]-1-(3-methylbutyl)-2-oxopyridine-3-carbonitrile
Show/Hide
|
C19H23N3O
|
1
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| 1 |
EC50 = 10715 nM
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CP0422158
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4-[4-[(1-methylbenzimidazol-2-yl)methyl]piperazin-1-yl]benzonitrile
Show/Hide
|
C20H21N5
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1
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| 1 |
EC50 > 12589.25 nM
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CP0497297
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2-[[4-[6-chloro-3-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]methyl]-1H-benzimidazole
Show/Hide
|
C18H17ClF3N5
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1
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| 1 |
EC50 = 12589.25 nM
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CP0506248
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2-[[4-(5-chloropyrimidin-2-yl)piperazin-1-yl]methyl]-1H-benzimidazole
Show/Hide
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C16H17ClN6
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1
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| 1 |
EC50 = 12589.25 nM
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CP0002355
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(2S)-2-aminopentanedioic acid
Show/Hide
|
C5H9NO4
|
1
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| 1 |
EC50 = 12589.25 nM
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CP0511230
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1-(2,2-dimethylpropyl)-5-methoxy-3-methylbenzimidazol-2-one
Show/Hide
|
C14H20N2O2
|
1
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| 1 |
EC50 = 12870 nM
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CP0488984
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1-methyl-2-[(4-pyridin-2-ylpiperidin-1-yl)methyl]benzimidazole
Show/Hide
|
C19H22N4
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2
|
| 1 |
EC50 > 15848.93 nM
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| 2 |
EC50 > 3162.28 nM
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CP0439586
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1-methyl-2-[(4-pyridin-2-ylpiperazin-1-yl)methyl]benzimidazole
Show/Hide
|
C18H21N5
|
1
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| 1 |
EC50 = 15848.93 nM
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CP0429986
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5-benzyl-3-phenyloxazolidin-2-one
Show/Hide
|
C16H15NO2
|
1
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| 1 |
EC50 = 25130 nM
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CP0383472
|
3-(2-chlorophenyl)-5-hexyloxazolidin-2-one
Show/Hide
|
C15H20ClNO2
|
1
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| 1 |
EC50 > 30000 nM
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CP0383478
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5-((2-ethylphenoxy)methyl)-3-phenyloxazolidin-2-one
Show/Hide
|
C18H19NO3
|
1
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| 1 |
EC50 > 30000 nM
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CP0383479
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N-[3-[(2-oxo-3-phenyl-1,3-oxazolidin-5-yl)methoxy]phenyl]acetamide
Show/Hide
|
C18H18N2O4
|
1
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| 1 |
EC50 > 30000 nM
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CP0386448
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5-((2-isopropylphenoxy)methyl)-3-phenyloxazolidin-2-one
Show/Hide
|
C19H21NO3
|
1
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| 1 |
EC50 > 30000 nM
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CP0386450
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4-((2-oxo-3-phenyloxazolidin-5-yl)methoxy)benzamide
Show/Hide
|
C17H16N2O4
|
1
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| 1 |
EC50 > 30000 nM
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CP0390534
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N-[4-[(2-oxo-3-phenyl-1,3-oxazolidin-5-yl)methoxy]phenyl]acetamide
Show/Hide
|
C18H18N2O4
|
1
|
| 1 |
EC50 > 30000 nM
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CP0400704
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3-phenyl-5-((2-(trifluoromethyl)phenoxy)methyl)oxazolidin-2-one
Show/Hide
|
C17H14F3NO3
|
1
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| 1 |
EC50 > 30000 nM
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CP0455526
|
5-((3-aminophenoxy)methyl)-3-phenyloxazolidin-2-one
Show/Hide
|
C16H16N2O3
|
1
|
| 1 |
EC50 > 30000 nM
|
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CP0455527
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3-((2-oxo-3-phenyloxazolidin-5-yl)methoxy)benzamide
Show/Hide
|
C17H16N2O4
|
1
|
| 1 |
EC50 > 30000 nM
|
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CP0475411
|
N-[2-[(2-oxo-3-phenyl-1,3-oxazolidin-5-yl)methoxy]phenyl]acetamide
Show/Hide
|
C18H18N2O4
|
1
|
| 1 |
EC50 > 30000 nM
|
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CP0487688
|
5-hexyl-3-(4-(methylsulfonyl)phenyl)oxazolidin-2-one
Show/Hide
|
C16H23NO4S
|
1
|
| 1 |
EC50 > 30000 nM
|
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CP0487689
|
3-phenyl-5-(o-tolyloxymethyl)oxazolidin-2-one
Show/Hide
|
C17H17NO3
|
1
|
| 1 |
EC50 > 30000 nM
|
|
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CP0487690
|
5-((4-aminophenoxy)methyl)-3-phenyloxazolidin-2-one
Show/Hide
|
C16H16N2O3
|
1
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| 1 |
EC50 > 30000 nM
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CP0496166
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(R)-3-(5-((4-tert-butylphenoxy)methyl)-2-oxooxazolidin-3-yl)benzonitrile
Show/Hide
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C21H22N2O3
|
1
|
| 1 |
EC50 > 30000 nM
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|
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CP0503918
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5-((2-methoxyphenoxy)methyl)-3-phenyloxazolidin-2-one
Show/Hide
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C17H17NO4
|
1
|
| 1 |
EC50 > 30000 nM
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|
|
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CP0514130
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5-hexyl-3-o-tolyloxazolidin-2-one
Show/Hide
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C16H23NO2
|
1
|
| 1 |
EC50 > 30000 nM
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|
|
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CP0536846
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1-(3-methylbutyl)-2-oxo-4-piperidin-1-ylpyridine-3-carbonitrile
Show/Hide
|
C16H23N3O
|
1
|
| 1 |
EC50 = 31623 nM
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|
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CP0542085
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1-oxo-2-propyl-6-pyridin-3-ylisoquinoline-8-carbonitrile
Show/Hide
|
C18H15N3O
|
1
|
| 1 |
EC50 > 50118.72 nM
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|
|
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CP0856368
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5-(benzylchloroamino)-2-propylisoquinolin-1(2H)-one
Show/Hide
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C19H19ClN2O
|
1
|
| 1 |
EC50 = 50118.72 nM
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|
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CP0479107
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(S)-1-(2-amino-2-carboxyethyl)-1H-1,2,3-triazole-4-carboxylic acid
Show/Hide
|
C6H8N4O4
|
1
|
| 1 |
EC50 > 100000 nM
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|
|
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CP0479108
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(S)-2-amino-3-(1-(carboxymethyl)-1H-1,2,3-triazol-4-yl)propanoic acid
Show/Hide
|
C7H10N4O4
|
1
|
| 1 |
EC50 > 100000 nM
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|
|
|
CP0501683
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(S)-2-amino-3-(1-(carboxymethyl)-1H-1,2,3-triazol-5-yl)propanoic acid
Show/Hide
|
C7H10N4O4
|
1
|
| 1 |
EC50 > 100000 nM
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|
|
|
CP0502129
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(S)-2-amino-3-(1-((S)-1-carboxy-2-phenylethyl)-1H-1,2,3-triazol-4-yl)propanoic acid
Show/Hide
|
C14H16N4O4
|
1
|
| 1 |
EC50 > 100000 nM
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|
|
|
CP0502130
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(S)-2-amino-3-(1-((S)-1-carboxy-2-phenylethyl)-1H-1,2,3-triazol-5-yl)propanoic acid
Show/Hide
|
C14H16N4O4
|
1
|
| 1 |
EC50 > 100000 nM
|
|
|
|
CP0383475
|
5-hexyl-3-(2-hydroxyphenyl)oxazolidin-2-one
Show/Hide
|
C15H21NO3
|
1
|
| 1 |
EC50 > 3000 nM
|
|
|
|
CP0383476
|
3-(2-aminophenyl)-5-hexyloxazolidin-2-one
Show/Hide
|
C15H22N2O2
|
1
|
| 1 |
EC50 > 3000 nM
|
|
|
|
CP0383477
|
methyl 2-(5-hexyl-2-oxo-1,3-oxazolidin-3-yl)benzoate
Show/Hide
|
C17H23NO4
|
1
|
| 1 |
EC50 > 3000 nM
|
|
|
|
CP0446993
|
5-hexyl-3-(2-methoxyphenyl)oxazolidin-2-one
Show/Hide
|
C16H23NO3
|
1
|
| 1 |
EC50 > 3000 nM
|
|
|
|
CP0487687
|
5-hexyl-3-(2-(methylsulfonyl)phenyl)oxazolidin-2-one
Show/Hide
|
C16H23NO4S
|
1
|
| 1 |
EC50 > 3000 nM
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|
|
|
CP0371724
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3-ethyl-7-(4-pyrimidin-2-ylpiperazin-1-yl)imidazo[1,2-a]pyridine-8-carbonitrile
Show/Hide
|
C18H19N7
|
1
|
| 1 |
EC50 > 3162.28 nM
|
|
|
|
CP0446539
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3-propyl-7-(4-pyrimidin-2-ylpiperazin-1-yl)imidazo[1,2-a]pyridine-8-carbonitrile
Show/Hide
|
C19H21N7
|
1
|
| 1 |
EC50 > 3162.28 nM
|
|
|
|
CP0470206
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3-phenyl-7-(4-phenylpiperazin-1-yl)imidazo[1,2-a]pyridine-8-carbonitrile
Show/Hide
|
C24H21N5
|
1
|
| 1 |
EC50 > 3162.28 nM
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|
|
|
CP0231490
|
7,8-dichloro-4-(3-(2-methylpyridin-4-yl)phenyl)-1H-benzo[b][1,4]diazepin-2(3H)-one
Show/Hide
|
C21H15Cl2N3O
|
1
|
| 1 |
IC50 = 7 nM
|
|
|
|
CP0237661
|
8-chloro-4-(3-(pyridin-4-yl)phenyl)-1H-benzo[b][1,4]diazepin-2(3H)-one
Show/Hide
|
C20H14ClN3O
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0202837
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4-(3-(2,6-dimethylpyridin-4-yl)phenyl)-7-methyl-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one
Show/Hide
|
C24H20F3N3O
|
1
|
| 1 |
IC50 = 14 nM
|
|
|
|
CP0232347
|
7-ethoxy-4-(3-(2-methylpyridin-4-yl)phenyl)-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one
Show/Hide
|
C24H20F3N3O2
|
1
|
| 1 |
IC50 = 15 nM
|
|
|
|
CP0295954
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4-(3-(2-methylpyridin-4-yl)phenyl)-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one
Show/Hide
|
C22H16F3N3O
|
1
|
| 1 |
IC50 = 25 nM
|
|
|
|
CP0338876
|
7-ethoxy-4-(3-(pyridin-4-yl)phenyl)-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one
Show/Hide
|
C23H18F3N3O2
|
1
|
| 1 |
IC50 = 38 nM
|
|
|
|
CP0053384
|
7-methyl-4-(3-(2-methylpyridin-4-yl)phenyl)-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one
Show/Hide
|
C23H18F3N3O
|
1
|
| 1 |
IC50 = 41 nM
|
|
|
|
CP0237670
|
4-(3-(pyridin-4-yl)phenyl)-8-(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one
Show/Hide
|
C21H14F3N3O
|
1
|
| 1 |
IC50 = 52 nM
|
|
|
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CP0411788
|
5-(1-(2,4-difluorophenyl)-5-methyl-1H-1,2,3-triazol-4-yl)-2-isopropylisoindolin-1-one
Show/Hide
|
C20H18F2N4O
|
1
|
| 1 |
IC50 > 10000 nM
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|
