General Information of the Compound
Compound ID
CP0404332
Compound Name
8-chloro-2-propyl-6-[4-[[6-(trifluoromethyl)pyridin-3-yl]methoxy]phenyl]isoquinolin-1-one
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Structure
Formula
C25H20ClF3N2O2
Molecular Weight
472.894
Canonical SMILES
CCCn1ccc2cc(cc(Cl)c2c1=O)-c1ccc(OCc2ccc(nc2)C(F)(F)F)cc1
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InChI
InChI=1S/C25H20ClF3N2O2/c1-2-10-31-11-9-18-12-19(13-21(26)23(18)24(31)32)17-4-6-20(7-5-17)33-15-16-3-8-22(30-14-16)25(27,28)29/h3-9,11-14H,2,10,15H2,1H3
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InChIKey
GFNPOQIZCADBHS-UHFFFAOYSA-N
Physicochemical Property
logP
6.7247
Rotatable Bonds
6
Heavy Atom Count
33
Polar Areas
44.12
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
4
Complexity
33

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 46917791
SID: 99383109
ChEMBL ID
CHEMBL1669400
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01748, Metabotropic glutamate receptor 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
EC50 = 251.19 nM
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