General Information of the Compound
Compound ID
CP0427758
Compound Name
8-chloro-7-[4-(5-fluoro-2-methoxyphenyl)piperidin-1-yl]-3-(2,2,2-trifluoroethyl)-[1,2,4]triazolo[4,3-a]pyridine
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Structure
Formula
C20H19ClF4N4O
Molecular Weight
442.844
Canonical SMILES
COc1ccc(F)cc1C1CCN(CC1)c1ccn2c(CC(F)(F)F)nnc2c1Cl
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InChI
InChI=1S/C20H19ClF4N4O/c1-30-16-3-2-13(22)10-14(16)12-4-7-28(8-5-12)15-6-9-29-17(11-20(23,24)25)26-27-19(29)18(15)21/h2-3,6,9-10,12H,4-5,7-8,11H2,1H3
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InChIKey
ZAHRLTQFDAVZMQ-UHFFFAOYSA-N
Physicochemical Property
logP
5.0192
Rotatable Bonds
4
Heavy Atom Count
30
Polar Areas
42.66
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
5
Complexity
30

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 57459497
SID: 163456173
ChEMBL ID
CHEMBL2206439
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01748, Metabotropic glutamate receptor 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
EC50 = 10.5 nM
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