| Compound ID |
Compound Name |
Compound Formula |
|
CP0196960
|
1-(azetidin-1-yl)-2-[4-[2-[(1S,2R)-2-[1-(5-chloropyrimidin-2-yl)piperidin-4-yl]cyclopropyl]ethoxy]-2-fluorophenyl]ethanone
Show/Hide
|
C25H30ClFN4O2
|
1
|
| 1 |
EC50 = 0.2 nM
|
|
|
|
CP0250773
|
1-(azetidin-1-yl)-2-[2,6-difluoro-4-[2-[(1S,2R)-2-[1-[5-(methoxymethyl)pyrimidin-2-yl]piperidin-4-yl]cyclopropyl]ethoxy]phenyl]ethanone
Show/Hide
|
C27H34F2N4O3
|
1
|
| 1 |
EC50 = 0.2 nM
|
|
|
|
CP0406757
|
1-(azetidin-1-yl)-2-[4-[2-[(1S,2R)-2-[1-(5-ethylpyrimidin-2-yl)piperidin-4-yl]cyclopropyl]ethoxy]-2-fluorophenyl]ethanone
Show/Hide
|
C27H35FN4O2
|
1
|
| 1 |
EC50 = 0.4 nM
|
|
|
|
CP0468083
|
propan-2-yl (1R,5R)-3-[6-(2-fluoro-4-methylsulfonylanilino)-5-nitropyrimidin-4-yl]oxy-8-azabicyclo[3.2.1]octane-8-carboxylate
Show/Hide
|
C22H26FN5O7S
|
1
|
| 1 |
EC50 = 0.6 nM
|
|
|
|
CP0406760
|
1-(azetidin-1-yl)-2-[2-fluoro-4-[2-[(1S,2R)-2-[1-[5-(methoxymethyl)pyrimidin-2-yl]piperidin-4-yl]cyclopropyl]ethoxy]phenyl]ethanone
Show/Hide
|
C27H35FN4O3
|
1
|
| 1 |
EC50 = 0.7 nM
|
|
|
|
CP0246804
|
2-[4-[2-[(1S,2R)-2-[1-(5-chloropyrimidin-2-yl)piperidin-4-yl]cyclopropyl]ethoxy]-2-fluorophenyl]-1-(3-hydroxyazetidin-1-yl)ethanone
Show/Hide
|
C25H30ClFN4O3
|
1
|
| 1 |
EC50 = 0.8 nM
|
|
|
|
CP0447464
|
1-(azetidin-1-yl)-2-[4-[2-[(1S,2R)-2-[1-(5-chloropyrimidin-2-yl)piperidin-4-yl]cyclopropyl]ethoxy]phenyl]ethanone
Show/Hide
|
C25H31ClN4O2
|
1
|
| 1 |
EC50 = 0.8 nM
|
|
|
|
CP0509584
|
tert-butyl (1R,4S,5S)-5-[6-(2-fluoro-4-methylsulfonylanilino)-5-nitropyrimidin-4-yl]oxy-2-azabicyclo[2.2.2]octane-2-carboxylate
Show/Hide
|
C23H28FN5O7S
|
1
|
| 1 |
EC50 = 1.2 nM
|
|
|
|
CP0377481
|
tert-butyl (1R,5R)-3-[[6-(4-cyano-2-fluoroanilino)-5-nitropyrimidin-4-yl]amino]-8-azabicyclo[3.2.1]octane-8-carboxylate
Show/Hide
|
C23H26FN7O4
|
1
|
| 1 |
EC50 = 1.3 nM
|
|
|
|
CP0468084
|
ethyl (1R,5R)-3-[6-(2-fluoro-4-methylsulfonylanilino)-5-nitropyrimidin-4-yl]oxy-8-azabicyclo[3.2.1]octane-8-carboxylate
Show/Hide
|
C21H24FN5O7S
|
1
|
| 1 |
EC50 = 1.4 nM
|
|
|
|
CP0897099
|
Endo-tert-butyl 3-(6-(2-fluoro-4-(methylsulfonyl)phenylamino)-5-nitropyrimidin-4-ylamino)-8-azabicyclo[3.2.1]octane-8-carboxylate
Show/Hide
|
C23H29FN6O6S
|
1
|
| 1 |
EC50 = 1.5 nM
|
|
|
|
CP0508440
|
tert-butyl (1R,5R)-3-[6-(2-fluoro-4-methylsulfonylanilino)-5-nitropyrimidin-4-yl]oxy-8-azabicyclo[3.2.1]octane-8-carboxylate
Show/Hide
|
C23H28FN5O7S
|
1
|
| 1 |
EC50 = 1.5 nM
|
|
|
|
CP0555452
|
tert-butyl (1R,5R)-3-[[6-(2-fluoro-4-methylsulfonylanilino)-5-nitropyrimidin-4-yl]amino]-8-azabicyclo[3.2.1]octane-8-carboxylate
Show/Hide
|
C23H29FN6O6S
|
1
|
| 1 |
EC50 = 1.5 nM
|
|
|
|
CP0112328
|
2-[4-[2-[(1S,2R)-2-[1-(5-chloropyrimidin-2-yl)piperidin-4-yl]cyclopropyl]ethoxy]-2-fluorophenyl]-1-piperidin-1-ylethanone
Show/Hide
|
C27H34ClFN4O2
|
1
|
| 1 |
EC50 = 1.5 nM
|
|
|
|
CP0468082
|
N-(2-fluoro-4-methylsulfonylphenyl)-6-[[(1R,5R)-8-methylsulfonyl-8-azabicyclo[3.2.1]octan-3-yl]oxy]-5-nitropyrimidin-4-amine
Show/Hide
|
C19H22FN5O7S2
|
1
|
| 1 |
EC50 = 1.6 nM
|
|
|
|
CP0365277
|
2-[4-[2-[(1S,2R)-2-[1-(5-chloropyrimidin-2-yl)piperidin-4-yl]cyclopropyl]ethoxy]phenyl]-N-cyclopropylacetamide
Show/Hide
|
C25H31ClN4O2
|
1
|
| 1 |
EC50 = 1.8 nM
|
|
|
|
CP0406759
|
1-(azetidin-1-yl)-2-[2-fluoro-4-[2-[(1S,2R)-2-[1-(3-propan-2-yl-1,2,4-oxadiazol-5-yl)piperidin-4-yl]cyclopropyl]ethoxy]phenyl]ethanone
Show/Hide
|
C26H35FN4O3
|
1
|
| 1 |
EC50 = 2 nM
|
|
|
|
CP0406761
|
1-(azetidin-1-yl)-2-[4-[2-[(1S,2R)-2-[1-(5-chloropyrimidin-2-yl)piperidin-4-yl]cyclopropyl]ethoxy]-3-fluorophenyl]ethanone
Show/Hide
|
C25H30ClFN4O2
|
1
|
| 1 |
EC50 = 2.2 nM
|
|
|
|
CP0904010
|
(1S,5S)-isobutyl 3-(6-(2-chloro-4-cyanophenylamino)-5-fluoropyrimidin-4-yloxy)-8-azabicyclo[3.2.1]octane-8-carboxylate
Show/Hide
|
C23H25ClFN5O3
|
1
|
| 1 |
EC50 = 2.6 nM
|
|
|
|
CP0310370
|
4-[(4-cyano-2-fluorophenoxy)methyl]-2-[1-(5-ethylpyrimidin-2-yl)piperidin-4-yl]pyrazole-3-carbonitrile
Show/Hide
|
C23H22FN7O
|
1
|
| 1 |
EC50 = 2.78 nM
|
|
|
|
CP0654582
|
3-chloro-4-(6-((1S,5S)-8-(cyclopropylsulfonyl)-8-azabicyclo[3.2.1]octan-3-yloxy)-5-methylpyrimidin-4-ylamino)benzonitrile
Show/Hide
|
C22H24ClN5O3S
|
1
|
| 1 |
EC50 = 3 nM
|
|
|
|
CP0488067
|
tert-butyl 4-[1-(4-methylsulfonylphenyl)triazole-4-carbonyl]piperazine-1-carboxylate
Show/Hide
|
C19H25N5O5S
|
1
|
| 1 |
EC50 = 3.12 nM
|
|
|
|
CP0106962
|
(1-methylcyclopropyl) 4-[(1R,2S)-2-[2-[4-[2-(azetidin-1-yl)-2-oxoethyl]-3-fluorophenoxy]ethyl]cyclopropyl]piperidine-1-carboxylate
Show/Hide
|
C26H35FN2O4
|
1
|
| 1 |
EC50 = 3.3 nM
|
|
|
|
CP0517421
|
N-(2-fluoro-4-methylsulfonylphenyl)-6-[[(1R,5R)-8-(4-fluorophenyl)sulfonyl-8-azabicyclo[3.2.1]octan-3-yl]oxy]-5-nitropyrimidin-4-amine
Show/Hide
|
C24H23F2N5O7S2
|
1
|
| 1 |
EC50 = 3.5 nM
|
|
|
|
CP0471863
|
(1-methylcyclopropyl) (1S,5S)-3-[6-(2-chloro-4-cyanoanilino)-5-fluoropyrimidin-4-yl]oxy-8-azabicyclo[3.2.1]octane-8-carboxylate
Show/Hide
|
C23H23ClFN5O3
|
1
|
| 1 |
EC50 = 3.5 nM
|
|
|
|
CP0542083
|
tert-butyl 4-[1-(4-cyano-2-fluorophenyl)triazole-4-carbonyl]oxypiperidine-1-carboxylate
Show/Hide
|
C20H22FN5O4
|
1
|
| 1 |
EC50 = 3.59 nM
|
|
|
|
CP0542082
|
tert-butyl 4-[1-(4-methylsulfonylphenyl)triazole-4-carbonyl]oxypiperidine-1-carboxylate
Show/Hide
|
C20H26N4O6S
|
1
|
| 1 |
EC50 = 3.67 nM
|
|
|
|
CP0336890
|
N-[(3S,4R)-3-fluoro-1-[[4-(trifluoromethyl)phenyl]methyl]piperidin-4-yl]-N-methyl-2-(4-methylsulfonylphenyl)acetamide
Show/Hide
|
C23H26F4N2O3S
|
1
|
| 1 |
EC50 = 4 nM
|
|
|
|
CP0453350
|
(1-methylcyclopropyl) 9-[6-(2-chloro-4-cyanoanilino)-5-methylpyrimidin-4-yl]oxy-3-oxa-7-azabicyclo[3.3.1]nonane-7-carboxylate
Show/Hide
|
C24H26ClN5O4
|
1
|
| 1 |
EC50 = 4 nM
|
|
|
|
CP0073883
|
4-[5-(3,3-dimethyl-2-oxaspiro[4.5]decan-8-yl)pentoxy]-N,N-dimethylbenzamide
Show/Hide
|
C25H39NO3
|
1
|
| 1 |
EC50 = 4 nM
|
|
|
|
CP0389998
|
4-[5-(3,3-dimethyl-1-oxaspiro[4.5]decan-8-yl)pentoxy]-N,N-dimethylbenzamide
Show/Hide
|
C25H39NO3
|
1
|
| 1 |
EC50 = 4 nM
|
|
|
|
CP0540910
|
tert-butyl 4-[1-(4-cyano-2-fluorophenyl)triazole-4-carbonyl]piperazine-1-carboxylate
Show/Hide
|
C19H21FN6O3
|
1
|
| 1 |
EC50 = 4.21 nM
|
|
|
|
CP0078155
|
(2-Fluoro-4-methanesulfonyl-phenyl)-{6-[4-(3-isopropyl-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-5-nitropyrimidin-4-yl}-amine
Show/Hide
|
C21H24FN7O5S
|
2
|
| 1 |
EC50 = 4.78 nM
|
|
|
| 2 |
EC50 = 640 nM
|
|
|
|
CP0450357
|
(1-methylcyclopropyl) 9-[6-(4-cyano-2-fluoroanilino)-5-methoxypyrimidin-4-yl]oxy-3-oxa-7-azabicyclo[3.3.1]nonane-7-carboxylate
Show/Hide
|
C24H26FN5O5
|
1
|
| 1 |
EC50 = 5 nM
|
|
|
|
CP0467766
|
tert-butyl 4-[5-[4-(dimethylcarbamoyl)phenoxy]pentyl]piperidine-1-carboxylate
Show/Hide
|
C24H38N2O4
|
1
|
| 1 |
EC50 = 5 nM
|
|
|
|
CP0477063
|
4-[(3,3-dimethyl-2-oxaspiro[4.5]decan-8-yl)oxy]-7-(2-fluoro-4-methylsulfonylphenyl)-5,6-dihydropyrrolo[2,3-d]pyrimidine
Show/Hide
|
C24H30FN3O4S
|
1
|
| 1 |
EC50 = 5 nM
|
|
|
|
CP0384658
|
CHEMBL4466171
Show/Hide
|
C23H30F2N2O5S
|
1
|
| 1 |
EC50 = 5 nM
|
|
|
|
CP0259933
|
tert-butyl (3R)-4-[5-[(3-cyanopyridin-4-yl)methoxy]pyrimidin-2-yl]-3-methylpiperazine-1-carboxylate
Show/Hide
|
C21H26N6O3
|
1
|
| 1 |
EC50 = 5.012 nM
|
|
|
|
CP0482309
|
(1-methylcyclobutyl) (1S,5S)-3-[6-(2-chloro-4-cyanoanilino)-5-fluoropyrimidin-4-yl]oxy-8-azabicyclo[3.2.1]octane-8-carboxylate
Show/Hide
|
C24H25ClFN5O3
|
1
|
| 1 |
EC50 = 5.1 nM
|
|
|
|
CP0523159
|
tert-butyl 5-[6-(2-fluoro-4-methylsulfonylanilino)-5-nitropyrimidin-4-yl]oxy-2-azabicyclo[2.2.1]heptane-2-carboxylate
Show/Hide
|
C22H26FN5O7S
|
1
|
| 1 |
EC50 = 5.6 nM
|
|
|
|
CP0393267
|
(1-methylcyclopropyl) (1R,5S)-9-[5-fluoro-6-(2-fluoroanilino)pyrimidin-4-yl]oxy-3-oxa-7-azabicyclo[3.3.1]nonane-7-carboxylate
Show/Hide
|
C22H24F2N4O4
|
1
|
| 1 |
EC50 = 6 nM
|
|
|
|
CP0532858
|
(1-ethylcyclopropyl) 9-[6-(4-cyano-2-fluoroanilino)-5-fluoropyrimidin-4-yl]oxy-3-oxa-7-azabicyclo[3.3.1]nonane-7-carboxylate
Show/Hide
|
C24H25F2N5O4
|
1
|
| 1 |
EC50 = 6 nM
|
|
|
|
CP0249964
|
CHEMBL4548931
Show/Hide
|
C22H26F4N2O5S
|
1
|
| 1 |
EC50 = 6 nM
|
|
|
|
CP0377480
|
propan-2-yl (1R,5R)-3-[[6-(2-fluoro-4-methylsulfonylanilino)-5-nitropyrimidin-4-yl]amino]-8-azabicyclo[3.2.1]octane-8-carboxylate
Show/Hide
|
C22H27FN6O6S
|
1
|
| 1 |
EC50 = 6.2 nM
|
|
|
|
CP0850513
|
Exo-tert-butyl 3-((6-(2-fluoro-4-(methylsulfonyl)phenylamino)-5-nitropyrimidin-4-ylamino)methyl)-8-azabicyclo[3.2.1]octane-8-carboxylate
Show/Hide
|
C24H31FN6O6S
|
1
|
| 1 |
EC50 = 6.7 nM
|
|
|
|
CP0895067
|
2-(6-((1S,5S)-8-(cyclopropylsulfonyl)-8-azabicyclo[3.2.1]octan-3-yloxy)-5-methylpyrimidin-4-yloxy)benzonitrile
Show/Hide
|
C22H24N4O4S
|
1
|
| 1 |
EC50 = 7 nM
|
|
|
|
CP0105308
|
N-[(3S,4R)-3-fluoro-1-[[4-(trifluoromethyl)phenyl]methyl]piperidin-4-yl]-N-methyl-2-[4-(tetrazol-1-yl)phenyl]acetamide
Show/Hide
|
C23H24F4N6O
|
1
|
| 1 |
EC50 = 7 nM
|
|
|
|
CP0376173
|
(1-methylcyclopropyl) 9-[6-(2-chloro-4-cyanoanilino)-5-methoxypyrimidin-4-yl]oxy-3-oxa-7-azabicyclo[3.3.1]nonane-7-carboxylate
Show/Hide
|
C24H26ClN5O5
|
1
|
| 1 |
EC50 = 7 nM
|
|
|
|
CP0414925
|
4-[5-(4,4-dimethyl-1-oxaspiro[5.5]undecan-9-yl)pentoxy]-N,N-dimethylbenzamide
Show/Hide
|
C26H41NO3
|
1
|
| 1 |
EC50 = 7 nM
|
|
|
|
CP0434814
|
3-[3,5-difluoro-4-(methylsulfonylmethyl)phenyl]-5-[(1R)-1-[(3,3-difluoro-1-oxaspiro[4.5]decan-8-yl)oxy]ethyl]-1,2,4-oxadiazole
Show/Hide
|
C21H24F4N2O5S
|
1
|
| 1 |
EC50 = 7 nM
|
|
|
|
CP0416566
|
tert-butyl 4-[1-(1,3-benzothiazol-2-yl)triazole-4-carbonyl]piperazine-1-carboxylate
Show/Hide
|
C19H22N6O3S
|
1
|
| 1 |
EC50 = 7.12 nM
|
|
|
|
CP0025099
|
4-[[2-[(2R)-2-methyl-4-(5-propan-2-yl-1,2,4-oxadiazol-3-yl)piperazin-1-yl]pyrimidin-5-yl]oxymethyl]pyridine-3-carbonitrile
Show/Hide
|
C21H24N8O2
|
1
|
| 1 |
EC50 = 7.943 nM
|
|
|
|
CP0536560
|
propan-2-yl (1S,5S)-3-[6-(2-chloro-4-cyanoanilino)-5-fluoropyrimidin-4-yl]oxy-8-azabicyclo[3.2.1]octane-8-carboxylate
Show/Hide
|
C22H23ClFN5O3
|
1
|
| 1 |
EC50 = 8 nM
|
|
|
|
CP0561226
|
tert-butyl 4-[1-(1,3-benzothiazol-2-yl)triazole-4-carbonyl]oxypiperidine-1-carboxylate
Show/Hide
|
C20H23N5O4S
|
1
|
| 1 |
EC50 = 8.17 nM
|
|
|
|
CP0542081
|
tert-butyl 4-[1-[2-chloro-4-(trifluoromethyl)phenyl]triazole-4-carbonyl]piperazine-1-carboxylate
Show/Hide
|
C19H21ClF3N5O3
|
1
|
| 1 |
EC50 = 8.78 nM
|
|
|
|
CP0382019
|
4-chloro-N-[2-methyl-5-(6-methyl-1,3-dioxo-2-propan-2-ylpyrrolo[3,4-c]pyridin-4-yl)oxyphenyl]benzenesulfonamide
Show/Hide
|
C24H22ClN3O5S
|
1
|
| 1 |
EC50 = 9 nM
|
|
|
|
CP0181432
|
1-(azetidin-1-yl)-2-[6-[2-[(1S,2R)-2-[1-(5-chloropyrimidin-2-yl)piperidin-4-yl]cyclopropyl]ethoxy]pyridin-3-yl]ethanone
Show/Hide
|
C24H30ClN5O2
|
1
|
| 1 |
EC50 = 9.4 nM
|
|
|
|
CP0412044
|
cyclobutyl 9-[6-(2-chloro-4-cyanoanilino)-5-fluoropyrimidin-4-yl]oxy-3-oxa-7-azabicyclo[3.3.1]nonane-7-carboxylate
Show/Hide
|
C23H23ClFN5O4
|
1
|
| 1 |
EC50 = 10 nM
|
|
|
|
CP0532848
|
(1-methylcyclobutyl) 9-[6-(2-chloro-4-cyanoanilino)-5-fluoropyrimidin-4-yl]oxy-3-oxa-7-azabicyclo[3.3.1]nonane-7-carboxylate
Show/Hide
|
C24H25ClFN5O4
|
1
|
| 1 |
EC50 = 10 nM
|
|
|
|
CP0960973
|
1-Methylcyclopropyl syn-9-[[6-[(2-chloro-4-cyanophenyl)amino]-5-fluoro-4-pyrimidinyl]oxy]-3-oxa-7-azabicyclo[3.3.1]nonane-7-carboxylate
Show/Hide
|
C23H23ClFN5O4
|
1
|
| 1 |
EC50 = 10 nM
|
|
|
|
CP0364571
|
propan-2-yl 4-[5-[4-(dimethylcarbamoyl)phenoxy]pentyl]piperidine-1-carboxylate
Show/Hide
|
C23H36N2O4
|
1
|
| 1 |
EC50 = 10 nM
|
|
|
|
CP0477305
|
tert-butyl 4-[1-[4-(trifluoromethyl)phenyl]triazole-4-carbonyl]oxypiperidine-1-carboxylate
Show/Hide
|
C20H23F3N4O4
|
1
|
| 1 |
EC50 = 10.43 nM
|
|
|
|
CP0282904
|
2-[1-(5-ethylpyrimidin-2-yl)piperidin-4-yl]-4-[[4-(tetrazol-1-yl)phenoxy]methyl]pyrazole-3-carbonitrile
Show/Hide
|
C23H24N10O
|
1
|
| 1 |
EC50 = 10.7 nM
|
|
|
|
CP0414916
|
4-chloro-N-methyl-N-[3-(6-methyl-1,3-dioxo-2-propan-2-ylpyrrolo[3,4-c]pyridin-4-yl)oxyphenyl]benzenesulfonamide
Show/Hide
|
C24H22ClN3O5S
|
1
|
| 1 |
EC50 = 11 nM
|
|
|
|
CP0458441
|
4-chloro-N-[3-(2-ethyl-6-methyl-1,3-dioxopyrrolo[3,4-c]pyridin-4-yl)oxyphenyl]benzenesulfonamide
Show/Hide
|
C22H18ClN3O5S
|
1
|
| 1 |
EC50 = 11 nM
|
|
|
|
CP0561225
|
tert-butyl 4-[1-[2-chloro-4-(trifluoromethyl)phenyl]triazole-4-carbonyl]oxypiperidine-1-carboxylate
Show/Hide
|
C20H22ClF3N4O4
|
1
|
| 1 |
EC50 = 11.12 nM
|
|
|
|
CP0894504
|
Endo-tert-butyl 3-(6-(4-(methylsulfonyl)phenylamino)-5-nitropyrimidin-4-ylamino)-8-azabicyclo[3.2.1]octane-8-carboxylate
Show/Hide
|
C23H30N6O6S
|
1
|
| 1 |
EC50 = 11.5 nM
|
|
|
|
CP0073436
|
N-[(3S,4R)-3-fluoro-1-[(5-fluoro-1,3-benzothiazol-2-yl)methyl]piperidin-4-yl]-N-methyl-2-[4-(tetrazol-1-yl)phenyl]acetamide
Show/Hide
|
C23H23F2N7OS
|
1
|
| 1 |
EC50 = 12 nM
|
|
|
|
CP0476413
|
methyl 1-[5-[(3R)-2-oxo-3-[6-(2,2,2-trifluoroethoxy)pyridin-3-yl]oxypyrrolidin-1-yl]pyridin-2-yl]azetidine-3-carboxylate
Show/Hide
|
C21H21F3N4O5
|
1
|
| 1 |
EC50 = 12 nM
|
|
|
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CP0562116
|
tert-butyl 4-[1-[4-chloro-3-(trifluoromethyl)phenyl]triazole-4-carbonyl]oxypiperidine-1-carboxylate
Show/Hide
|
C20H22ClF3N4O4
|
1
|
| 1 |
EC50 = 12.31 nM
|
|
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|
CP0439963
|
tert-butyl 4-[1-[4-chloro-3-(trifluoromethyl)phenyl]triazole-4-carbonyl]piperazine-1-carboxylate
Show/Hide
|
C19H21ClF3N5O3
|
1
|
| 1 |
EC50 = 12.34 nM
|
|
|
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CP0552544
|
tert-butyl 4-[1-(2-fluoro-4-methylsulfonylphenyl)triazole-4-carbonyl]piperazine-1-carboxylate
Show/Hide
|
C19H24FN5O5S
|
1
|
| 1 |
EC50 = 12.43 nM
|
|
|
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CP0438245
|
tert-butyl 4-[1-[[2-(2,3,6-trifluorophenyl)acetyl]amino]propan-2-yl]piperidine-1-carboxylate
Show/Hide
|
C21H29F3N2O3
|
1
|
| 1 |
EC50 = 13 nM
|
|
|
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CP0417965
|
tert-butyl 6-[6-[2-fluoro-4-(tetrazol-1-yl)phenoxy]-5-methylpyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate
Show/Hide
|
C25H29FN8O3
|
1
|
| 1 |
EC50 = 13 nM
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|
|
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CP0375598
|
ethyl 2-[3-[(4-chlorophenyl)sulfonylamino]phenoxy]-3-cyano-6-methylpyridine-4-carboxylate
Show/Hide
|
C22H18ClN3O5S
|
1
|
| 1 |
EC50 = 13 nM
|
|
|
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CP0413197
|
4-chloro-N-[3-(6-methyl-1,3-dioxo-2-propan-2-ylpyrrolo[3,4-c]pyridin-4-yl)oxyphenyl]benzenesulfonamide
Show/Hide
|
C23H20ClN3O5S
|
1
|
| 1 |
EC50 = 13 nM
|
|
|
|
CP0389678
|
(1-methylcyclopropyl) (1R,5S)-9-[6-(2,6-difluoroanilino)-5-fluoropyrimidin-4-yl]oxy-3-oxa-7-azabicyclo[3.3.1]nonane-7-carboxylate
Show/Hide
|
C22H23F3N4O4
|
1
|
| 1 |
EC50 = 13 nM
|
|
|
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CP0424165
|
6-[(3,3-dimethyl-2-oxaspiro[4.5]decan-8-yl)oxy]-N-(2-fluoro-4-methylsulfonylphenyl)-5-methylpyrimidin-4-amine
Show/Hide
|
C23H30FN3O4S
|
1
|
| 1 |
EC50 = 13 nM
|
|
|
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CP0561224
|
tert-butyl 4-[1-[4-(trifluoromethyl)phenyl]triazole-4-carbonyl]piperazine-1-carboxylate
Show/Hide
|
C19H22F3N5O3
|
1
|
| 1 |
EC50 = 13.56 nM
|
|
|
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CP0384333
|
tert-butyl 4-[1-(2-fluoro-4-methylsulfonylphenyl)triazole-4-carbonyl]oxypiperidine-1-carboxylate
Show/Hide
|
C20H25FN4O6S
|
1
|
| 1 |
EC50 = 13.98 nM
|
|
|
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CP0545819
|
tert-butyl 4-[5-(4-methylsulfonylphenoxy)pentyl]piperidine-1-carboxylate
Show/Hide
|
C22H35NO5S
|
1
|
| 1 |
EC50 = 14 nM
|
|
|
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CP0220713
|
propan-2-yl 4-[5-methyl-6-(2-methylpyridin-3-yl)oxypyrimidin-4-yl]oxypiperidine-1-carboxylate
Show/Hide
|
C20H26N4O4
|
1
|
| 1 |
EC50 = 15 nM
|
|
|
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CP0847545
|
(1S,5S)-8-(isobutylsulfonyl)-3-(5-methyl-6-(2-methylpyridin-3-yloxy)pyrimidin-4-yloxy)-8-azabicyclo[3.2.1]octane
Show/Hide
|
C22H30N4O4S
|
1
|
| 1 |
EC50 = 15 nM
|
|
|
|
CP0895060
|
4-(6-((1S,5S)-8-(cyclopropylsulfonyl)-8-azabicyclo[3.2.1]octan-3-yloxy)-5-methylpyrimidin-4-ylamino)-3-fluorobenzonitrile
Show/Hide
|
C22H24FN5O3S
|
1
|
| 1 |
EC50 = 15 nM
|
|
|
|
CP0461916
|
4-chloro-N-[3-(2-cyclopropyl-6-methyl-1,3-dioxopyrrolo[3,4-c]pyridin-4-yl)oxyphenyl]benzenesulfonamide
Show/Hide
|
C23H18ClN3O5S
|
1
|
| 1 |
EC50 = 15 nM
|
|
|
|
CP0887619
|
1-methylcyclopropyl 9-(6-(2,4-difluorophenylamino)-5-fluoropyrimidin-4-yloxy)-3-oxa-7-azabicyclo[3.3.1]nonane-7-carboxylate
Show/Hide
|
C22H23F3N4O4
|
1
|
| 1 |
EC50 = 15 nM
|
|
|
|
CP0517671
|
1-[6-[(3,3-dimethyl-2-oxaspiro[4.5]decan-8-yl)oxy]pyrimidin-4-yl]-5-methylsulfonyl-2,3-dihydroindole
Show/Hide
|
C24H31N3O4S
|
1
|
| 1 |
EC50 = 15 nM
|
|
|
|
CP0868802
|
4-((2-((R)-4-(5-((S)-1-methoxyethyl)-1,2,4-oxadiazol-3-yl)-2-methylpiperazin-1-yl)pyrimidin-5-yloxy)methyl)nicotinonitrile
Show/Hide
|
C21H24N8O3
|
1
|
| 1 |
EC50 = 15.85 nM
|
|
|
|
CP0893051
|
4-((2-((R)-4-(5-((R)-1-methoxyethyl)-1,2,4-oxadiazol-3-yl)-2-methylpiperazin-1-yl)pyrimidin-5-yloxy)methyl)nicotinonitrile
Show/Hide
|
C21H24N8O3
|
1
|
| 1 |
EC50 = 15.85 nM
|
|
|
|
CP0893106
|
(3R)-3-(trifluoromethyl)tetrahydrofuran-3-yl 4-(5-((3-cyanopyridin-4-yl)methoxy)pyrimidin-2-yl)-3-methylpiperazine-1-carboxylate
Show/Hide
|
C22H23F3N6O4
|
1
|
| 1 |
EC50 = 15.85 nM
|
|
|
|
CP0428076
|
tert-butyl 6-[5-ethyl-6-(2-methylpyridin-3-yl)oxypyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate
Show/Hide
|
C25H33N5O3
|
1
|
| 1 |
EC50 = 16 nM
|
|
|
|
CP0407645
|
ethyl 2-chloro-6-[3-[(4-chlorophenyl)sulfonylamino]phenoxy]pyridine-4-carboxylate
Show/Hide
|
C20H16Cl2N2O5S
|
2
|
| 1 |
EC50 = 16 nM
|
|
|
| 2 |
EC50 = 20 nM
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|
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CP0551842
|
4-chloro-N-[4-fluoro-3-(6-methyl-1,3-dioxo-2-propan-2-ylpyrrolo[3,4-c]pyridin-4-yl)oxyphenyl]benzenesulfonamide
Show/Hide
|
C23H19ClFN3O5S
|
1
|
| 1 |
EC50 = 16 nM
|
|
|
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CP0460295
|
(1-methylcyclopropyl) 9-[6-(2-chloro-4-cyanophenoxy)-5-methylpyrimidin-4-yl]oxy-3-oxa-7-azabicyclo[3.3.1]nonane-7-carboxylate
Show/Hide
|
C24H25ClN4O5
|
1
|
| 1 |
EC50 = 16 nM
|
|
|
|
CP0436074
|
N-(3,3-dimethyl-2-oxaspiro[4.5]decan-8-yl)-N-methyl-6-(5-methylsulfonyl-2,3-dihydroindol-1-yl)pyrimidin-4-amine
Show/Hide
|
C25H34N4O3S
|
1
|
| 1 |
EC50 = 16 nM
|
|
|
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CP0476799
|
tert-butyl 6-[5-methyl-6-[4-(tetrazol-1-yl)phenoxy]pyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate
Show/Hide
|
C25H30N8O3
|
1
|
| 1 |
EC50 = 17 nM
|
|
|
|
CP0389695
|
(1-methylcyclopropyl) 9-[6-[(2-chloropyridin-3-yl)amino]-5-fluoropyrimidin-4-yl]oxy-3-oxa-7-azabicyclo[3.3.1]nonane-7-carboxylate
Show/Hide
|
C21H23ClFN5O4
|
1
|
| 1 |
EC50 = 17 nM
|
|
|
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CP0847540
|
(1S,5S)-1-methylcyclopropyl 3-(5-methyl-6-(2-methylpyridin-3-yloxy)pyrimidin-4-yloxy)-8-azabicyclo[3.2.1]octane-8-carboxylate
Show/Hide
|
C23H28N4O4
|
1
|
| 1 |
EC50 = 18 nM
|
|
|
|
CP0917214
|
(1R,5R)-isopropyl 3-(5-methyl-6-(2-methylpyridin-3-yloxy)pyrimidin-4-yloxy)-8-azabicyclo[3.2.1]oct-6-ene-8-carboxylate
Show/Hide
|
C22H26N4O4
|
1
|
| 1 |
EC50 = 18 nM
|
|
|
|
CP0338363
|
N-[(3S,4R)-3-fluoro-1-[(5-fluoro-1,3-benzothiazol-2-yl)methyl]piperidin-4-yl]-N-methyl-2-(4-methylsulfonylphenyl)acetamide
Show/Hide
|
C23H25F2N3O3S2
|
1
|
| 1 |
EC50 = 18 nM
|
|
|
|
CP0418348
|
4-chloro-N-[3-(2-cyclopropyl-6-methoxy-1,3-dioxopyrrolo[3,4-c]pyridin-4-yl)oxyphenyl]benzenesulfonamide
Show/Hide
|
C23H18ClN3O6S
|
1
|
| 1 |
EC50 = 19 nM
|
|
|
|
CP0524115
|
4-chloro-N-[3-(6-methyl-1,3-dioxo-2-propan-2-ylpyrrolo[3,4-c]pyridin-4-yl)sulfanylphenyl]benzenesulfonamide
Show/Hide
|
C23H20ClN3O4S2
|
1
|
| 1 |
EC50 = 19 nM
|
|
|
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CP0571134
|
tert-butyl 4-[7-(2-fluoro-4-methylsulfonylanilino)triazolo[4,5-d]pyrimidin-3-yl]piperidine-1-carboxylate
Show/Hide
|
C21H26FN7O4S
|
1
|
| 1 |
EC50 = 19 nM
|
|
|
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CP0906581
|
1-methylcyclopropyl 9-(5-fluoro-6-(2-fluoro-4-(1H-1,2,4-triazol-1-yl)phenylamino)pyrimidin-4-yloxy)-3-oxa-7-azabicyclo[3.3.1]nonane-7-carboxylate
Show/Hide
|
C24H25F2N7O4
|
1
|
| 1 |
EC50 = 19 nM
|
|
|
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CP0357047
|
4-N-(3,3-dimethyl-2-oxaspiro[4.5]decan-8-yl)-6-N-(2-fluoro-4-methylsulfonylphenyl)pyrimidine-4,6-diamine
Show/Hide
|
C22H29FN4O3S
|
1
|
| 1 |
EC50 = 19 nM
|
|
|
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CP0210924
|
(1-methylcyclopropyl) 4-[5-cyano-4-[(4-cyano-2-fluorophenoxy)methyl]pyrazol-1-yl]piperidine-1-carboxylate
Show/Hide
|
C22H22FN5O3
|
1
|
| 1 |
EC50 = 19.3 nM
|
|
|
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CP0690692
|
(R)-3-(trifluoromethyl)oxetan-3-yl 4-(5-((3-cyanopyridin-4-yl)methoxy)pyrimidin-2-yl)-3-methylpiperazine-1-carboxylate
Show/Hide
|
C21H21F3N6O4
|
1
|
| 1 |
EC50 = 19.95 nM
|
|
|
|
CP0433407
|
4-chloro-N-[3-[6-chloro-4-(3-propan-2-yl-1,2,4-oxadiazol-5-yl)pyridin-2-yl]oxyphenyl]benzenesulfonamide
Show/Hide
|
C22H18Cl2N4O4S
|
2
|
| 1 |
EC50 = 20 nM
|
|
|
| 2 |
EC50 = 24 nM
|
|
|
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CP0545818
|
N,N-dimethyl-4-[5-(1-oxaspiro[5.5]undecan-9-yl)pentoxy]benzamide
Show/Hide
|
C24H37NO3
|
1
|
| 1 |
EC50 = 21 nM
|
|
|
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CP0417964
|
(1-methylcyclopropyl) 6-[6-[2-fluoro-4-(tetrazol-1-yl)phenoxy]-5-methylpyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate
Show/Hide
|
C25H27FN8O3
|
1
|
| 1 |
EC50 = 22 nM
|
|
|
|
CP0388345
|
(1-methylcyclopropyl) 4-[5-cyano-4-[[4-(tetrazol-1-yl)phenoxy]methyl]pyrazol-1-yl]piperidine-1-carboxylate
Show/Hide
|
C22H24N8O3
|
1
|
| 1 |
EC50 = 22.1 nM
|
|
|
|
CP0414917
|
4-chloro-N-[3-(2,6-dimethyl-1,3-dioxopyrrolo[3,4-c]pyridin-4-yl)oxyphenyl]benzenesulfonamide
Show/Hide
|
C21H16ClN3O5S
|
1
|
| 1 |
EC50 = 23 nM
|
|
|
|
CP0895062
|
(1S,5S)-isopropyl 3-(5-methyl-6-(2-methylpyridin-3-yloxy)pyrimidin-4-yloxy)-8-azabicyclo[3.2.1]octane-8-carboxylate
Show/Hide
|
C22H28N4O4
|
1
|
| 1 |
EC50 = 24 nM
|
|
|
|
CP0895065
|
(1S,5S)-8-(cyclopropylsulfonyl)-3-(5-methyl-6-(2-methylpyridin-3-yloxy)pyrimidin-4-yloxy)-8-azabicyclo[3.2.1]octane
Show/Hide
|
C21H26N4O4S
|
1
|
| 1 |
EC50 = 24 nM
|
|
|
|
CP0246603
|
N-[(3S,4R)-1-(1,3-benzothiazol-2-ylmethyl)-3-fluoropiperidin-4-yl]-N-methyl-2-(4-methylsulfonylphenyl)acetamide
Show/Hide
|
C23H26FN3O3S2
|
1
|
| 1 |
EC50 = 24 nM
|
|
|
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CP0895066
|
(1S,5S)-8-(5-chlorothiophen-2-ylsulfonyl)-3-(5-methyl-6-(2-methylpyridin-3-yloxy)pyrimidin-4-yloxy)-8-azabicyclo[3.2.1]octane
Show/Hide
|
C22H23ClN4O4S2
|
1
|
| 1 |
EC50 = 25 nM
|
|
|
|
CP0406105
|
(1-methylcyclopropyl) 9-[6-(2-chloro-4-cyanoanilino)pyrimidin-4-yl]oxy-3-oxa-7-azabicyclo[3.3.1]nonane-7-carboxylate
Show/Hide
|
C23H24ClN5O4
|
1
|
| 1 |
EC50 = 25 nM
|
|
|
|
CP0384654
|
CHEMBL4458134
Show/Hide
|
C24H33FN2O5S
|
1
|
| 1 |
EC50 = 25 nM
|
|
|
|
CP0121403
|
4-[[2-[(2R)-2-methyl-4-[5-(trifluoromethyl)-1,3,4-oxadiazol-2-yl]piperazin-1-yl]pyrimidin-5-yl]oxymethyl]pyridine-3-carbonitrile
Show/Hide
|
C19H17F3N8O2
|
1
|
| 1 |
EC50 = 25.12 nM
|
|
|
|
CP0532857
|
(1-methylcyclopropyl) 9-[5-fluoro-6-(2-fluorophenoxy)pyrimidin-4-yl]oxy-3-oxa-7-azabicyclo[3.3.1]nonane-7-carboxylate
Show/Hide
|
C22H23F2N3O5
|
1
|
| 1 |
EC50 = 26 nM
|
|
|
|
CP0467765
|
N,N-dimethyl-4-(5-spiro[5.5]undecan-3-ylpentoxy)benzamide
Show/Hide
|
C25H39NO2
|
1
|
| 1 |
EC50 = 27 nM
|
|
|
|
CP0444077
|
5-[(1R)-1-[(3,3-dimethyl-2-oxaspiro[4.5]decan-8-yl)oxy]ethyl]-3-[3-fluoro-4-(methylsulfonylmethyl)phenyl]-1,2,4-oxadiazole
Show/Hide
|
C23H31FN2O5S
|
1
|
| 1 |
EC50 = 27 nM
|
|
|
|
CP0553148
|
3-[3,5-difluoro-4-(methylsulfonylmethyl)phenyl]-5-[(1R)-1-[(4,4-difluoro-1-oxaspiro[5.5]undecan-9-yl)oxy]ethyl]-1,2,4-oxadiazole
Show/Hide
|
C22H26F4N2O5S
|
1
|
| 1 |
EC50 = 27 nM
|
|
|
|
CP0237666
|
N-[(3R,4S)-3-methoxy-1-[[4-(trifluoromethyl)phenyl]methyl]piperidin-4-yl]-N-methyl-2-[4-(tetrazol-1-yl)phenyl]acetamide
Show/Hide
|
C24H27F3N6O2
|
1
|
| 1 |
EC50 = 29 nM
|
|
|
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CP0342687
|
N-[(3R,4S)-3-fluoro-1-[[4-(trifluoromethyl)phenyl]methyl]piperidin-4-yl]-N-methyl-2-[4-(tetrazol-1-yl)phenyl]acetamide
Show/Hide
|
C23H24F4N6O
|
1
|
| 1 |
EC50 = 29 nM
|
|
|
|
CP0090790
|
propan-2-yl 4-[6-(2-fluoro-4-methylsulfonylphenoxy)-5-methylpyrimidin-4-yl]oxypiperidine-1-carboxylate
Show/Hide
|
C21H26FN3O6S
|
1
|
| 1 |
EC50 = 29 nM
|
|
|
|
CP0529096
|
4-[5-(1,5-dioxaspiro[5.5]undecan-9-yl)pentoxy]-N,N-dimethylbenzamide
Show/Hide
|
C23H35NO4
|
1
|
| 1 |
EC50 = 29 nM
|
|
|
|
CP0384359
|
CHEMBL4441437
Show/Hide
|
C24H33FN2O5S
|
1
|
| 1 |
EC50 = 29 nM
|
|
|
|
CP0917215
|
(1S,5S)-cyclobutyl 3-(5-methyl-6-(2-methylpyridin-3-yloxy)pyrimidin-4-yloxy)-8-azabicyclo[3.2.1]octane-8-carboxylate
Show/Hide
|
C23H28N4O4
|
1
|
| 1 |
EC50 = 30 nM
|
|
|
|
CP0917216
|
(1S,5S)-8-(butylsulfonyl)-3-(5-methyl-6-(2-methylpyridin-3-yloxy)pyrimidin-4-yloxy)-8-azabicyclo[3.2.1]octane
Show/Hide
|
C22H30N4O4S
|
1
|
| 1 |
EC50 = 30 nM
|
|
|
|
CP0411411
|
4-[[7-[6-chloro-4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)pyridin-2-yl]oxy-3,4-dihydro-2H-quinolin-1-yl]sulfonyl]benzonitrile
Show/Hide
|
C26H20ClN5O4S
|
1
|
| 1 |
EC50 = 30 nM
|
|
|
|
CP0421049
|
methyl 2-chloro-6-[[1-(4-chlorophenyl)sulfonyl-2,3-dihydroindol-6-yl]oxy]pyridine-4-carboxylate
Show/Hide
|
C21H16Cl2N2O5S
|
1
|
| 1 |
EC50 = 30 nM
|
|
|
|
CP0500859
|
2-[3-[(4-chlorophenyl)sulfonylamino]phenoxy]-3-cyano-N,6-dicyclopropylpyridine-4-carboxamide
Show/Hide
|
C25H21ClN4O4S
|
1
|
| 1 |
EC50 = 31 nM
|
|
|
|
CP0541824
|
5-[1-[(3,3-dimethyl-1-oxaspiro[4.5]decan-8-yl)oxy]ethyl]-3-[3-fluoro-4-(methylsulfonylmethyl)phenyl]-1,2,4-oxadiazole
Show/Hide
|
C23H31FN2O5S
|
1
|
| 1 |
EC50 = 31 nM
|
|
|
|
CP0381426
|
propan-2-yl 4-[1-[[2-(2,3,6-trifluorophenyl)acetyl]amino]propan-2-yl]piperidine-1-carboxylate
Show/Hide
|
C20H27F3N2O3
|
1
|
| 1 |
EC50 = 32 nM
|
|
|
|
CP0922343
|
(1S,5S)-3-(5-methyl-6-(2-methylpyridin-3-yloxy)pyrimidin-4-yloxy)-8-(propylsulfonyl)-8-azabicyclo[3.2.1]octane
Show/Hide
|
C21H28N4O4S
|
1
|
| 1 |
EC50 = 32 nM
|
|
|
|
CP0551843
|
4-chloro-N-[4-chloro-3-(6-methyl-1,3-dioxo-2-propan-2-ylpyrrolo[3,4-c]pyridin-4-yl)oxyphenyl]benzenesulfonamide
Show/Hide
|
C23H19Cl2N3O5S
|
1
|
| 1 |
EC50 = 33 nM
|
|
|
|
CP0477062
|
4-[[6-[(3,3-dimethyl-2-oxaspiro[4.5]decan-8-yl)oxy]-5-methylpyrimidin-4-yl]amino]-3-fluoro-N,N-dimethylbenzamide
Show/Hide
|
C25H33FN4O3
|
1
|
| 1 |
EC50 = 33 nM
|
|
|
|
CP0847543
|
2-(6-((1S,5S)-8-(cyclopropylsulfonyl)-8-azabicyclo[3.2.1]octan-3-yloxy)-5-methylpyrimidin-4-ylamino)-5-fluorobenzonitrile
Show/Hide
|
C22H24FN5O3S
|
1
|
| 1 |
EC50 = 34 nM
|
|
|
|
CP0465309
|
propan-2-yl 6-[6-[2-fluoro-4-(tetrazol-1-yl)phenoxy]-5-methylpyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate
Show/Hide
|
C24H27FN8O3
|
1
|
| 1 |
EC50 = 34 nM
|
|
|
|
CP0564260
|
N,N-dimethyl-4-[5-(1-oxaspiro[5.5]undecan-9-yl)pentoxy]benzamide
Show/Hide
|
C24H37NO3
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1
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| 1 |
EC50 = 36 nM
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CP0847544
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(1S,5S)-cyclopropylmethyl 3-(5-methyl-6-(2-methylpyridin-3-yloxy)pyrimidin-4-yloxy)-8-azabicyclo[3.2.1]octane-8-carboxylate
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C23H28N4O4
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1
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| 1 |
EC50 = 37 nM
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CP0895061
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(1R,5R)-8-(cyclopropylsulfonyl)-3-(5-methyl-6-(2-methylpyridin-3-yloxy)pyrimidin-4-yloxy)-8-azabicyclo[3.2.1]oct-6-ene
Show/Hide
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C21H24N4O4S
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1
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| 1 |
EC50 = 38 nM
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CP0915408
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(1S,5S)-1-cyclopropylethyl 3-(5-methyl-6-(2-methylpyridin-3-yloxy)pyrimidin-4-yloxy)-8-azabicyclo[3.2.1]octane-8-carboxylate
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C24H30N4O4
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1
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| 1 |
EC50 = 38 nM
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CP0449241
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(1-methylcyclopropyl) 6-[5-methyl-6-[4-(tetrazol-1-yl)phenoxy]pyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate
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C25H28N8O3
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1
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| 1 |
EC50 = 39 nM
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CP0555156
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N-(3,3-dimethyl-2-oxaspiro[4.5]decan-8-yl)-7-(2-fluoro-4-methylsulfonylphenyl)-N-methyl-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-amine
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C25H33FN4O3S
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1
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| 1 |
EC50 = 39 nM
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CP0386166
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tert-butyl 6-[6-(2-fluoro-4-methylsulfonylphenoxy)-5-methylpyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate
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C25H31FN4O5S
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1
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| 1 |
EC50 = 40 nM
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CP0428078
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tert-butyl 6-[5-methyl-6-(2-methylpyridin-3-yl)oxypyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate
Show/Hide
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C24H31N5O3
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1
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| 1 |
EC50 = 40 nM
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CP0329981
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propan-2-yl 4-[1-(4-methylsulfonylphenyl)pyrazolo[3,4-d]pyrimidin-4-yl]oxypiperidine-1-carboxylate
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C21H25N5O5S
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2
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| 1 |
EC50 = 40 nM
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| 2 |
EC50 = 41 nM
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CP0431729
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5-[2-chloro-6-[[1-(4-chlorophenyl)sulfonyl-6-fluoro-3,4-dihydro-2H-quinolin-7-yl]oxy]pyridin-4-yl]-3-cyclopropyl-1,2,4-oxadiazole
Show/Hide
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C25H19Cl2FN4O4S
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1
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| 1 |
EC50 = 40 nM
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CP0847546
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(1S,5S)-8-(4-fluorophenylsulfonyl)-3-(5-methyl-6-(2-methylpyridin-3-yloxy)pyrimidin-4-yloxy)-8-azabicyclo[3.2.1]octane
Show/Hide
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C24H25FN4O4S
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1
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| 1 |
EC50 = 42 nM
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CP0515224
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US9469631, 48
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C21H25F2N5O3
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1
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| 1 |
EC50 = 42 nM
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CP0424163
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6-[(3,3-dimethyl-2-oxaspiro[4.5]decan-8-yl)oxy]-5-ethyl-N-(2-fluoro-4-methylsulfonylphenyl)pyrimidin-4-amine
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C24H32FN3O4S
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1
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| 1 |
EC50 = 42 nM
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CP0210925
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(1-methylcyclopropyl) 4-[5-cyano-4-[[2-fluoro-4-(1-methyltetrazol-5-yl)phenoxy]methyl]pyrazol-1-yl]piperidine-1-carboxylate
Show/Hide
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C23H25FN8O3
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2
|
| 1 |
EC50 = 43.6 nM
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| 2 |
EC50 = 141 nM
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CP0474446
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(1-methylcyclopropyl) 4-[(2S)-1-[[2-(2,3,6-trifluorophenyl)acetyl]amino]propan-2-yl]piperidine-1-carboxylate
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C21H27F3N2O3
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1
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| 1 |
EC50 = 44 nM
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CP0915403
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(1S,5S)-3-(6-(2-chlorophenoxy)-5-methylpyrimidin-4-yloxy)-8-(cyclopropylsulfonyl)-8-azabicyclo[3.2.1]octane
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C21H24ClN3O4S
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1
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| 1 |
EC50 = 44 nM
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CP0453358
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tert-butyl 7-[6-(2-chloro-4-methylsulfonylanilino)-5-methylpyrimidin-4-yl]oxy-3-oxa-9-azabicyclo[3.3.1]nonane-9-carboxylate
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C24H31ClN4O6S
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1
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| 1 |
EC50 = 44 nM
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CP0384657
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5-[1-[(3,3-dimethyl-2-oxaspiro[4.5]decan-8-yl)oxy]ethyl]-3-[3-fluoro-4-(methylsulfonylmethyl)phenyl]-1,2,4-oxadiazole
Show/Hide
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C23H31FN2O5S
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1
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| 1 |
EC50 = 44 nM
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CP0508443
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tert-butyl (1R,5R)-3-[6-(2-chlorophenoxy)-5-nitropyrimidin-4-yl]oxy-8-azabicyclo[3.2.1]octane-8-carboxylate
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C22H25ClN4O6
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1
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| 1 |
EC50 = 44.2 nM
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CP0549117
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4-chloro-N-[3-(2,6-dicyclopropyl-1,3-dioxopyrrolo[3,4-c]pyridin-4-yl)oxyphenyl]benzenesulfonamide
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C25H20ClN3O5S
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1
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| 1 |
EC50 = 45 nM
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CP0436075
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4-N-(3,3-dimethyl-2-oxaspiro[4.5]decan-8-yl)-6-N-(2-fluoro-4-methylsulfonylphenyl)-4-N,5-dimethylpyrimidine-4,6-diamine
Show/Hide
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C24H33FN4O3S
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1
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| 1 |
EC50 = 45 nM
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CP0425682
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(5-ethylpyrimidin-2-yl) 4-[4-[(2-fluoro-4-methylsulfonylanilino)methyl]pyrazol-1-yl]piperidine-1-carboxylate
Show/Hide
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C23H27FN6O4S
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1
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| 1 |
EC50 = 47 nM
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CP0396609
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(1-methylcyclopropyl) 6-[5-ethyl-6-(2-methylpyridin-3-yl)oxypyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate
Show/Hide
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C25H31N5O3
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1
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| 1 |
EC50 = 49 nM
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CP0532859
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[1-(methoxymethyl)cyclopropyl] 9-[6-(4-cyano-2-fluoroanilino)-5-fluoropyrimidin-4-yl]oxy-3-oxa-7-azabicyclo[3.3.1]nonane-7-carboxylate
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C24H25F2N5O5
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1
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| 1 |
EC50 = 49 nM
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CP0895068
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5-chloro-2-(6-((1S,5S)-8-(cyclopropylsulfonyl)-8-azabicyclo[3.2.1]octan-3-yloxy)-5-methylpyrimidin-4-yloxy)benzonitrile
Show/Hide
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C22H23ClN4O4S
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1
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| 1 |
EC50 = 50 nM
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CP0463892
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ethyl 2-[3-[(4-chlorophenyl)sulfonylamino]phenoxy]-6-methylpyridine-4-carboxylate
Show/Hide
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C21H19ClN2O5S
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1
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| 1 |
EC50 = 50 nM
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CP0149543
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5-[2-chloro-6-[[1-(4-chlorophenyl)sulfonyl-3,4-dihydro-2H-quinolin-7-yl]oxy]pyridin-4-yl]-3-cyclopropyl-1,2,4-oxadiazole
Show/Hide
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C25H20Cl2N4O4S
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1
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| 1 |
EC50 = 50 nM
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CP0421052
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3-tert-butyl-5-[2-chloro-6-[[1-(4-chlorophenyl)sulfonyl-3,4-dihydro-2H-quinolin-7-yl]oxy]pyridin-4-yl]-1,2,4-oxadiazole
Show/Hide
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C26H24Cl2N4O4S
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1
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| 1 |
EC50 = 50 nM
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CP0437780
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5-[2-chloro-6-[[1-(4-chlorophenyl)sulfonyl-3,4-dihydro-2H-quinolin-7-yl]oxy]pyridin-4-yl]-3-propan-2-yl-1,2,4-oxadiazole
Show/Hide
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C25H22Cl2N4O4S
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1
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| 1 |
EC50 = 50 nM
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CP0261635
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N-[1-[[3-fluoro-4-(trifluoromethyl)phenyl]methyl]piperidin-4-yl]-N-methyl-2-[4-(tetrazol-1-yl)phenyl]acetamide
Show/Hide
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C23H24F4N6O
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1
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| 1 |
EC50 = 53 nM
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CP0917217
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6-((1S,5S)-8-(cyclopropylsulfonyl)-8-azabicyclo[3.2.1]octan-3-yloxy)-5-methyl-N-(2-methylpyridin-3-yl)pyrimidin-4-amine
Show/Hide
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C21H27N5O3S
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1
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| 1 |
EC50 = 54 nM
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CP0564956
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5-[(3R)-3-[6-(cyclopropylmethoxy)pyridin-3-yl]oxy-2-oxopyrrolidin-1-yl]-2-(3-hydroxyazetidin-1-yl)pyridine-3-carbonitrile
Show/Hide
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C22H23N5O4
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1
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| 1 |
EC50 = 57 nM
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CP0452674
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4-[(3,3-dimethyl-2-oxaspiro[4.5]decan-8-yl)oxy]-6-(2-fluoro-4-methylsulfonylphenoxy)-5-methylpyrimidine
Show/Hide
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C23H29FN2O5S
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1
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| 1 |
EC50 = 59 nM
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CP0421046
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7-chloro-6-[6-chloro-4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)pyridin-2-yl]oxy-4-(4-chlorophenyl)sulfonyl-2,3-dihydro-1,4-benzoxazine
Show/Hide
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C24H17Cl3N4O5S
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1
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| 1 |
EC50 = 60 nM
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CP0421048
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5-[2-chloro-6-[[1-(4-chlorophenyl)sulfonyl-3,4-dihydro-2H-quinolin-7-yl]oxy]pyridin-4-yl]-3-(cyclopropylmethyl)-1,2,4-oxadiazole
Show/Hide
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C26H22Cl2N4O4S
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1
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| 1 |
EC50 = 60 nM
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CP0467260
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5-[2-chloro-6-[[1-(4-chlorophenyl)sulfonyl-2,3-dihydroindol-6-yl]oxy]pyridin-4-yl]-3-cyclopropyl-1,2,4-oxadiazole
Show/Hide
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C24H18Cl2N4O4S
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1
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| 1 |
EC50 = 60 nM
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CP0847541
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(1S,5S)-2,2,2-trifluoroethyl 3-(5-methyl-6-(2-methylpyridin-3-yloxy)pyrimidin-4-yloxy)-8-azabicyclo[3.2.1]octane-8-carboxylate
Show/Hide
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C21H23F3N4O4
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1
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| 1 |
EC50 = 61 nM
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CP0377829
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(1R,3S,5R)-8-(cyclopropylsulfonyl)-6,6-difluoro-3-(5-methyl-6-(2-methylpyridin-3-yloxy)pyrimidin-4-yloxy)-8-azabicyclo[3.2.1]octane
Show/Hide
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C21H24F2N4O4S
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1
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| 1 |
EC50 = 62 nM
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CP0881291
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(R)-4-((2-(2-methyl-4-(5-(3-methyloxetan-3-yl)-1,2,4-oxadiazol-3-yl)piperazin-1-yl)pyrimidin-5-yloxy)methyl)nicotinonitrile
Show/Hide
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C22H24N8O3
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1
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| 1 |
EC50 = 63.1 nM
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CP0483375
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3-[2,5-difluoro-4-(methylsulfonylmethyl)phenyl]-5-[(1R)-1-[(3,3-dimethyl-2-oxaspiro[4.5]decan-8-yl)oxy]ethyl]-1,2,4-oxadiazole
Show/Hide
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C23H30F2N2O5S
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1
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| 1 |
EC50 = 64 nM
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CP0269948
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2-[4-[2-[(1S,2R)-2-[1-(5-chloropyrimidin-2-yl)piperidin-4-yl]cyclopropyl]ethoxy]phenyl]acetamide
Show/Hide
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C22H27ClN4O2
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1
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| 1 |
EC50 = 67 nM
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CP0433408
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4-chloro-N-[3-[6-chloro-4-(1,3-thiazol-2-yl)pyridin-2-yl]oxyphenyl]benzenesulfonamide
Show/Hide
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C20H13Cl2N3O3S2
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1
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| 1 |
EC50 = 68 nM
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CP0414913
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4-chloro-N-[3-(2-cyclopentyl-6-methyl-1,3-dioxopyrrolo[3,4-c]pyridin-4-yl)oxyphenyl]benzenesulfonamide
Show/Hide
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C25H22ClN3O5S
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1
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| 1 |
EC50 = 69 nM
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CP0434812
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2-[4-[5-[1-[(3,3-dimethyl-2-oxaspiro[4.5]decan-8-yl)oxy]ethyl]-1,2,4-oxadiazol-3-yl]-2-fluorophenyl]-N,N-dimethylacetamide
Show/Hide
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C25H34FN3O4
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1
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| 1 |
EC50 = 69 nM
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CP0421045
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2-[2-chloro-6-[[1-(4-chlorophenyl)sulfonyl-6-fluoro-3,4-dihydro-2H-quinolin-7-yl]oxy]pyridin-4-yl]-5-cyclopropyl-1,3,4-oxadiazole
Show/Hide
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C25H19Cl2FN4O4S
|
1
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| 1 |
EC50 = 70 nM
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CP0437779
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5-[2-chloro-6-[[1-(3,4-dichlorophenyl)sulfonyl-3,4-dihydro-2H-quinolin-7-yl]oxy]pyridin-4-yl]-3-cyclopropyl-1,2,4-oxadiazole
Show/Hide
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C25H19Cl3N4O4S
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1
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| 1 |
EC50 = 70 nM
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CP0375029
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(1-methylcyclopropyl) 7-[6-(2-fluoro-4-methylsulfonylanilino)-5-methylpyrimidin-4-yl]oxy-3-oxa-9-azabicyclo[3.3.1]nonane-9-carboxylate
Show/Hide
|
C24H29FN4O6S
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1
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| 1 |
EC50 = 70 nM
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CP0073435
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N-methyl-2-[4-(tetrazol-1-yl)phenyl]-N-[1-[[4-(trifluoromethyl)phenyl]methyl]piperidin-4-yl]acetamide
Show/Hide
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C23H25F3N6O
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1
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| 1 |
EC50 = 74 nM
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CP0395910
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tert-butyl 4-[1-[[2-(2,3-difluorophenyl)acetyl]amino]propan-2-yl]piperidine-1-carboxylate
Show/Hide
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C21H30F2N2O3
|
1
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| 1 |
EC50 = 75 nM
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CP0460402
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(1-methylcyclobutyl) 6-[5-methyl-6-(2-methylpyridin-3-yl)oxypyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate
Show/Hide
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C25H31N5O3
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1
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| 1 |
EC50 = 75 nM
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CP0110601
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N-[1-[(5-fluoro-1,3-benzothiazol-2-yl)methyl]piperidin-4-yl]-N-methyl-2-[4-(tetrazol-1-yl)phenyl]acetamide
Show/Hide
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C23H24FN7OS
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1
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| 1 |
EC50 = 76 nM
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CP0437219
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tert-butyl 6-[6-(2-fluoro-4-methylsulfonylanilino)-5-nitropyrimidin-4-yl]oxy-2-azabicyclo[2.2.1]heptane-2-carboxylate
Show/Hide
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C22H26FN5O7S
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1
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| 1 |
EC50 = 77.7 nM
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CP0438284
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tert-butyl 4-[1-[[2-(2,5-difluorophenyl)acetyl]amino]propan-2-yl]piperidine-1-carboxylate
Show/Hide
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C21H30F2N2O3
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1
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| 1 |
EC50 = 78 nM
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CP0529097
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tert-butyl 4-[6-(4-methylsulfonylphenoxy)hexyl]piperidine-1-carboxylate
Show/Hide
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C23H37NO5S
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1
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| 1 |
EC50 = 78 nM
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CP0378680
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(S)-1-methylcyclopropyl 4-(1-fluoro-2-(2-(2,3,6-trifluorophenyl)acetamido)ethyl)piperidine-1-carboxylate
Show/Hide
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C20H24F4N2O3
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1
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| 1 |
EC50 = 80 nM
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CP0421047
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2-[2-chloro-6-[[6-chloro-1-(4-chlorophenyl)sulfonyl-3,4-dihydro-2H-quinolin-7-yl]oxy]pyridin-4-yl]-5-cyclopropyl-1,3,4-oxadiazole
Show/Hide
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C25H19Cl3N4O4S
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1
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| 1 |
EC50 = 80 nM
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CP0431723
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2-[2-chloro-6-[[1-(4-chlorophenyl)sulfonyl-3,4-dihydro-2H-quinolin-7-yl]oxy]pyridin-4-yl]-5-cyclopropyl-1,3,4-oxadiazole
Show/Hide
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C25H20Cl2N4O4S
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1
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| 1 |
EC50 = 80 nM
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CP0431724
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5-[2-chloro-6-[[1-(4-chlorophenyl)sulfonyl-3,4-dihydro-2H-quinolin-7-yl]oxy]pyridin-4-yl]-3-ethyl-1,2,4-oxadiazole
Show/Hide
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C24H20Cl2N4O4S
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1
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| 1 |
EC50 = 80 nM
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CP0439864
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5-[2-chloro-6-[[6-chloro-1-(4-chlorophenyl)sulfonyl-3,4-dihydro-2H-quinolin-7-yl]oxy]pyridin-4-yl]-3-cyclopropyl-1,2,4-oxadiazole
Show/Hide
|
C25H19Cl3N4O4S
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1
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| 1 |
EC50 = 80 nM
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CP0487360
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5-[2-chloro-6-[[1-(4-methylphenyl)sulfonyl-3,4-dihydro-2H-quinolin-7-yl]oxy]pyridin-4-yl]-3-cyclopropyl-1,2,4-oxadiazole
Show/Hide
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C26H23ClN4O4S
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1
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| 1 |
EC50 = 80 nM
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CP0498951
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propan-2-yl 4-[6-(2-fluoro-4-methylsulfonylphenoxy)pyrimidin-4-yl]oxypiperidine-1-carboxylate
Show/Hide
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C20H24FN3O6S
|
1
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| 1 |
EC50 = 82 nM
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CP0494083
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N-(2-fluoro-4-methylsulfonylphenyl)-3-[1-(5-propylpyrimidin-2-yl)piperidin-4-yl]triazolo[4,5-d]pyrimidin-7-amine
Show/Hide
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C23H26FN9O2S
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1
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| 1 |
EC50 = 82 nM
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CP0459376
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N-methyl-1-[5-[(3R)-2-oxo-3-[6-(2,2,2-trifluoroethoxy)pyridin-3-yl]oxypyrrolidin-1-yl]pyrimidin-2-yl]-N-propan-2-ylazetidine-3-carboxamide
Show/Hide
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C23H27F3N6O4
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1
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| 1 |
EC50 = 82 nM
|
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CP0868061
|
5-(1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)-2-(2-fluoro-4-(methylsulfonyl)phenyl)-2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole hydrochloride
Show/Hide
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C23H28ClFN6O2S
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1
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| 1 |
EC50 = 83 nM
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CP0534516
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2-(3,3-dimethyl-2-oxaspiro[4.5]decan-8-yl)-4-[[4-(tetrazol-1-yl)phenoxy]methyl]-1,3-thiazole
Show/Hide
|
C22H27N5O2S
|
1
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| 1 |
EC50 = 85 nM
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CP0847548
|
2-(6-((1S,5S)-8-(cyclopropylsulfonyl)-8-azabicyclo[3.2.1]octan-3-yloxy)-5-methylpyrimidin-4-ylamino)benzonitrile
Show/Hide
|
C22H25N5O3S
|
1
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| 1 |
EC50 = 86 nM
|
|
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CP0541823
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3-[3-fluoro-4-(methylsulfonylmethyl)phenyl]-5-[1-(1-oxaspiro[5.5]undecan-9-yloxy)ethyl]-1,2,4-oxadiazole
Show/Hide
|
C22H29FN2O5S
|
1
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| 1 |
EC50 = 86 nM
|
|
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CP0460405
|
2-methylpropyl 6-[5-methyl-6-(2-methylpyridin-3-yl)oxypyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate
Show/Hide
|
C24H31N5O3
|
1
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| 1 |
EC50 = 88 nM
|
|
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CP0410417
|
4-[5-(1,4-dioxaspiro[4.5]decan-8-yl)pentoxy]-N,N-dimethylbenzamide
Show/Hide
|
C22H33NO4
|
1
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| 1 |
EC50 = 88 nM
|
|
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CP0407047
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4-chloro-N-[3-[6-chloro-4-(4-ethyl-1,3-thiazol-2-yl)pyridin-2-yl]oxyphenyl]benzenesulfonamide
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C22H17Cl2N3O3S2
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1
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| 1 |
EC50 = 89 nM
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CP0521318
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CHEMBL4467856
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C22H29FN2O5S
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1
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| 1 |
EC50 = 89 nM
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CP0390124
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5-[2-chloro-6-[[1-(4-fluorophenyl)sulfonyl-3,4-dihydro-2H-quinolin-7-yl]oxy]pyridin-4-yl]-3-cyclopropyl-1,2,4-oxadiazole
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C25H20ClFN4O4S
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1
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| 1 |
EC50 = 90 nM
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CP0431721
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5-[2-chloro-6-[[1-(4-methoxyphenyl)sulfonyl-3,4-dihydro-2H-quinolin-7-yl]oxy]pyridin-4-yl]-3-cyclopropyl-1,2,4-oxadiazole
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C26H23ClN4O5S
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1
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| 1 |
EC50 = 90 nM
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CP0471440
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5-[2-chloro-6-[[1-(3,4-difluorophenyl)sulfonyl-3,4-dihydro-2H-quinolin-7-yl]oxy]pyridin-4-yl]-3-cyclopropyl-1,2,4-oxadiazole
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C25H19ClF2N4O4S
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1
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| 1 |
EC50 = 90 nM
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CP0407048
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4-chloro-N-[3-[6-chloro-4-(1,3-oxazol-2-yl)pyridin-2-yl]oxyphenyl]benzenesulfonamide
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C20H13Cl2N3O4S
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1
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| 1 |
EC50 = 91 nM
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CP0547500
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N,N-dimethyl-4-[5-(1-oxaspiro[4.5]decan-8-yl)pentoxy]benzamide
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C23H35NO3
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1
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| 1 |
EC50 = 95 nM
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CP0476797
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tert-butyl 6-[6-[2-fluoro-4-(1,2,4-triazol-1-yl)phenoxy]-5-methylpyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate
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C26H30FN7O3
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1
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| 1 |
EC50 = 96 nM
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CP0451038
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(1-methylcyclopropyl) (1R,5R)-7-[6-(2-fluoro-4-methylsulfonylanilino)-5-methoxypyrimidin-4-yl]oxy-3-oxa-9-azabicyclo[3.3.1]nonane-9-carboxylate
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C24H29FN4O7S
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1
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| 1 |
EC50 = 97 nM
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CP0477064
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6-[(3,3-dimethyl-2-oxaspiro[4.5]decan-8-yl)oxy]-N-(2-fluoro-4-methylsulfonylphenyl)-5-propan-2-ylpyrimidin-4-amine
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C25H34FN3O4S
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1
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| 1 |
EC50 = 98 nM
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CP0386157
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propan-2-yl 6-[5-methyl-6-[4-(tetrazol-1-yl)phenoxy]pyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate
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C24H28N8O3
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1
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| 1 |
EC50 = 100 nM
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CP0421044
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5-[2-chloro-6-[[1-(4-chlorophenyl)sulfonyl-3,4-dihydro-2H-quinolin-7-yl]oxy]pyridin-4-yl]-3-cyclopropyl-1,2-oxazole
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C26H21Cl2N3O4S
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1
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| 1 |
EC50 = 100 nM
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CP0431728
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ethyl 2-chloro-6-[[1-(4-chlorophenyl)sulfonyl-3,4-dihydro-2H-quinolin-7-yl]oxy]pyridine-4-carboxylate
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C23H20Cl2N2O5S
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1
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| 1 |
EC50 = 100 nM
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CP0439863
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methyl 2-chloro-6-[[1-(4-chlorophenyl)sulfonyl-3,4-dihydro-2H-quinolin-7-yl]oxy]pyridine-4-carboxylate
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C22H18Cl2N2O5S
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1
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| 1 |
EC50 = 100 nM
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CP0467258
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5-[2-chloro-6-[[7-chloro-4-(4-chlorophenyl)sulfonyl-2,3-dihydro-1,4-benzothiazin-6-yl]oxy]pyridin-4-yl]-3-cyclopropyl-1,2,4-oxadiazole
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C24H17Cl3N4O4S2
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1
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| 1 |
EC50 = 100 nM
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CP0471439
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5-[2-[[1-(4-chlorophenyl)sulfonyl-3,4-dihydro-2H-quinolin-7-yl]oxy]-6-fluoropyridin-4-yl]-3-cyclopropyl-1,2,4-oxadiazole
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C25H20ClFN4O4S
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1
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| 1 |
EC50 = 100 nM
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CP0868801
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4-((2-((2R)-4-(5-(1,4-dioxan-2-yl)-1,2,4-oxadiazol-3-yl)-2-methylpiperazin-1-yl)pyrimidin-5-yloxy)methyl)nicotinonitrile
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C22H24N8O4
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1
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| 1 |
EC50 = 100 nM
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CP0445544
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5-[2-chloro-6-[[1-(4-chlorophenyl)sulfonyl-3,4-dihydro-2H-quinolin-7-yl]oxy]pyridin-4-yl]-3-(trifluoromethyl)-1,2,4-oxadiazole
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C23H15Cl2F3N4O4S
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1
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| 1 |
EC50 = 110 nM
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CP0447279
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tert-butyl 5-[6-(4-methylsulfonylanilino)-5-nitropyrimidin-4-yl]oxy-2-azabicyclo[2.2.1]heptane-2-carboxylate
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C22H27N5O7S
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1
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| 1 |
EC50 = 110 nM
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CP0847542
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(1S,5S)-3-(5-methyl-6-(2-methylpyridin-3-yloxy)pyrimidin-4-yloxy)-8-(2,2,2-trifluoroethylsulfonyl)-8-azabicyclo[3.2.1]octane
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C20H23F3N4O4S
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1
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| 1 |
EC50 = 112 nM
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CP0917218
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(1S,5S)-3-(5-methyl-6-(2-methylpyridin-3-yloxy)pyrimidin-4-yloxy)-8-(3,3,3-trifluoropropylsulfonyl)-8-azabicyclo[3.2.1]octane
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C21H25F3N4O4S
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1
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| 1 |
EC50 = 112 nM
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CP0480370
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tert-butyl 4-[1-[[2-(2,6-difluorophenyl)acetyl]amino]propan-2-yl]piperidine-1-carboxylate
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C21H30F2N2O3
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1
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| 1 |
EC50 = 120 nM
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CP0462319
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5-[2-[[1-(4-chlorophenyl)sulfonyl-3,4-dihydro-2H-quinolin-7-yl]oxy]-6-methylpyridin-4-yl]-3-cyclopropyl-1,2,4-oxadiazole
Show/Hide
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C26H23ClN4O4S
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1
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| 1 |
EC50 = 120 nM
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CP0449176
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propan-2-yl 6-[6-(2-fluoro-4-methylsulfonylphenoxy)-5-methylpyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate
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C24H29FN4O5S
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1
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| 1 |
EC50 = 121 nM
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CP0458442
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4-chloro-N-[3-(6-methyl-1,3-dioxopyrrolo[3,4-c]pyridin-4-yl)oxyphenyl]benzenesulfonamide
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C20H14ClN3O5S
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1
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| 1 |
EC50 = 121 nM
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CP0073439
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2-(2-fluoro-4-methylsulfonylphenyl)-N-methyl-N-[1-[[4-(trifluoromethyl)phenyl]methyl]piperidin-4-yl]acetamide
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C23H26F4N2O3S
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1
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| 1 |
EC50 = 122 nM
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CP0460707
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(1R,3S,5R)-8-(cyclopropylsulfonyl)-6-fluoro-3-(5-methyl-6-(2-methylpyridin-3-yloxy)pyrimidin-4-yloxy)-8-azabicyclo[3.2.1]octane
Show/Hide
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C21H25FN4O4S
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1
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| 1 |
EC50 = 130 nM
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CP0449177
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cyclobutyl 6-[5-methyl-6-(2-methylpyridin-3-yl)oxypyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate
Show/Hide
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C24H29N5O3
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1
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| 1 |
EC50 = 130 nM
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CP0515299
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ethyl 2-[3-[(4-chlorophenyl)sulfonylamino]phenoxy]-3-cyano-6-cyclopropylpyridine-4-carboxylate
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C24H20ClN3O5S
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1
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| 1 |
EC50 = 130 nM
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CP0430027
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5-[2-[[1-(4-chlorophenyl)sulfonyl-3,4-dihydro-2H-quinolin-7-yl]oxy]-6-cyclopropylpyridin-4-yl]-3-cyclopropyl-1,2,4-oxadiazole
Show/Hide
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C28H25ClN4O4S
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1
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| 1 |
EC50 = 130 nM
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CP0915400
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(1S,5S)-ethyl 3-(5-methyl-6-(2-methylpyridin-3-yloxy)pyrimidin-4-yloxy)-8-azabicyclo[3.2.1]octane-8-carboxylate
Show/Hide
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C21H26N4O4
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1
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| 1 |
EC50 = 131 nM
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CP0237669
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2-(3-fluoro-4-methylsulfonylphenyl)-N-methyl-N-[1-[[4-(trifluoromethyl)phenyl]methyl]piperidin-4-yl]acetamide
Show/Hide
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C23H26F4N2O3S
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1
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| 1 |
EC50 = 131 nM
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CP0529095
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N,N-dimethyl-4-[5-(1-oxaspiro[4.5]decan-8-yl)pentoxy]benzamide
Show/Hide
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C23H35NO3
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1
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| 1 |
EC50 = 132 nM
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CP0424161
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6-[(3,3-dimethyl-2-oxaspiro[4.5]decan-8-yl)oxy]-5-methyl-N-(4-methylsulfonylphenyl)pyrimidin-4-amine
Show/Hide
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C23H31N3O4S
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1
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| 1 |
EC50 = 139 nM
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CP0246604
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N-[(3S,4R)-3-fluoro-1-[[5-(trifluoromethyl)pyridin-2-yl]methyl]piperidin-4-yl]-N-methyl-2-[4-(tetrazol-1-yl)phenyl]acetamide
Show/Hide
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C22H23F4N7O
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1
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| 1 |
EC50 = 140 nM
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CP0465312
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tert-butyl 6-[5-methyl-6-[4-(1,2,4-triazol-1-yl)phenoxy]pyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate
Show/Hide
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C26H31N7O3
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1
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| 1 |
EC50 = 140 nM
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CP0439866
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3-[2-chloro-6-[[1-(4-chlorophenyl)sulfonyl-3,4-dihydro-2H-quinolin-7-yl]oxy]pyridin-4-yl]-5-cyclopropyl-1,2,4-oxadiazole
Show/Hide
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C25H20Cl2N4O4S
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1
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| 1 |
EC50 = 140 nM
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CP0386162
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tert-butyl 6-[5-methoxy-6-(2-methylpyridin-3-yl)oxypyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate
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C24H31N5O4
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1
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| 1 |
EC50 = 144 nM
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CP0425700
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tert-butyl 6-[6-(4-cyano-2-fluorophenoxy)-5-methylpyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate
Show/Hide
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C25H28FN5O3
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1
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| 1 |
EC50 = 144 nM
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CP0481439
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[(2R)-butan-2-yl] 6-[5-methyl-6-(2-methylpyridin-3-yl)oxypyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate
Show/Hide
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C24H31N5O3
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1
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| 1 |
EC50 = 145 nM
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CP0428080
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[(2S)-butan-2-yl] 6-[5-methyl-6-(2-methylpyridin-3-yl)oxypyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate
Show/Hide
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C24H31N5O3
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1
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| 1 |
EC50 = 155 nM
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CP0840907
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(R)-4-((2-(4-(5-isopropyl-1,3,4-oxadiazol-2-yl)-2-methylpiperazin-1-yl)pyrimidin-5-yloxy)methyl)nicotinonitrile
Show/Hide
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C21H24N8O2
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1
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| 1 |
EC50 = 158.49 nM
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CP0411399
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ethyl 2-[3-[(4-chlorophenyl)sulfonylamino]phenoxy]pyridine-4-carboxylate
Show/Hide
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C20H17ClN2O5S
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1
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| 1 |
EC50 = 160 nM
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CP0417966
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propan-2-yl 6-[5-ethyl-6-(2-methylpyridin-3-yl)oxypyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate
Show/Hide
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C24H31N5O3
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1
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| 1 |
EC50 = 164 nM
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CP0910358
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6-((1S,5S)-8-(cyclopropylsulfonyl)-8-azabicyclo[3.2.1]octan-3-yloxy)-N-(2-fluoro-4-(methylsulfonyl)phenyl)-5-methylpyrimidin-4-amine
Show/Hide
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C22H27FN4O5S2
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1
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| 1 |
EC50 = 166 nM
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CP0440141
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(1-methylcyclopropyl) 6-[6-(2-fluoro-4-methylsulfonylphenoxy)-5-methylpyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate
Show/Hide
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C25H29FN4O5S
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1
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| 1 |
EC50 = 169 nM
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CP0333173
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N-[(3S,4R)-3-methoxy-1-[[4-(trifluoromethyl)phenyl]methyl]piperidin-4-yl]-N-methyl-2-[4-(tetrazol-1-yl)phenyl]acetamide
Show/Hide
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C24H27F3N6O2
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1
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| 1 |
EC50 = 172 nM
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CP0439865
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5-[2-chloro-6-[[1-(3-methylsulfonylphenyl)sulfonyl-3,4-dihydro-2H-quinolin-7-yl]oxy]pyridin-4-yl]-3-cyclopropyl-1,2,4-oxadiazole
Show/Hide
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C26H23ClN4O6S2
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1
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| 1 |
EC50 = 180 nM
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CP0458408
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5-[2-chloro-6-[[1-(4-chlorophenyl)sulfonyl-3,4-dihydro-2H-quinolin-7-yl]oxy]pyridin-4-yl]-3-methyl-1,2,4-oxadiazole
Show/Hide
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C23H18Cl2N4O4S
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1
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| 1 |
EC50 = 180 nM
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CP0433412
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propan-2-yl 4-[4-[(2-fluoro-4-methylsulfonylanilino)methyl]pyrazol-1-yl]piperidine-1-carboxylate
Show/Hide
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C20H27FN4O4S
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1
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| 1 |
EC50 = 181 nM
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CP0389676
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(3-methyloxetan-3-yl)methyl 9-[6-(2-chloro-4-cyanoanilino)-5-fluoropyrimidin-4-yl]oxy-3-oxa-7-azabicyclo[3.3.1]nonane-7-carboxylate
Show/Hide
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C24H25ClFN5O5
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1
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| 1 |
EC50 = 188 nM
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CP0439855
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5-[2-chloro-6-[[1-(4-chlorophenyl)sulfonyl-3,4-dihydro-2H-quinolin-7-yl]oxy]pyridin-4-yl]-3-(2,2,2-trifluoroethyl)-1,2,4-oxadiazole
Show/Hide
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C24H17Cl2F3N4O4S
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1
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| 1 |
EC50 = 190 nM
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CP0890135
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(R)-3-isopropyloxetan-3-yl 4-(5-((3-cyanopyridin-4-yl)methoxy)pyrimidin-2-yl)-3-methylpiperazine-1-carboxylate
Show/Hide
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C23H28N6O4
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1
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| 1 |
EC50 = 199.53 nM
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CP0894309
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(R)-3-methyloxetan-3-yl 4-(5-((3-cyanopyridin-4-yl)methoxy)pyrimidin-2-yl)-3-methylpiperazine-1-carboxylate
Show/Hide
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C21H24N6O4
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1
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| 1 |
EC50 = 199.53 nM
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CP0894314
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(R)-3-ethyloxetan-3-yl 4-(5-((3-cyanopyridin-4-yl)methoxy)pyrimidin-2-yl)-3-methylpiperazine-1-carboxylate
Show/Hide
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C22H26N6O4
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1
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| 1 |
EC50 = 199.53 nM
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CP0417963
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propan-2-yl 6-[5-methyl-6-[4-(triazol-1-yl)phenoxy]pyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate
Show/Hide
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C25H29N7O3
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1
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| 1 |
EC50 = 202 nM
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CP0548912
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tert-butyl (1R,5R)-3-[[6-(2-chloro-4-cyanoanilino)-5-nitropyrimidin-4-yl]amino]-8-azabicyclo[3.2.1]octane-8-carboxylate
Show/Hide
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C23H26ClN7O4
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1
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| 1 |
EC50 = 205 nM
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CP0415572
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tert-butyl 4-[4-(4-methylsulfonylphenoxy)butyl]piperidine-1-carboxylate
Show/Hide
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C21H33NO5S
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1
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| 1 |
EC50 = 209 nM
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CP0389677
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3-chloro-4-[5-cyclopropyl-6-[[7-(5-fluoropyrimidin-2-yl)-3-oxa-7-azabicyclo[3.3.1]nonan-9-yl]oxy]pyrimidin-4-yl]oxybenzonitrile
Show/Hide
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C25H22ClFN6O3
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1
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| 1 |
EC50 = 212 nM
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CP0526563
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4-chloro-N-[2-methyl-5-(6-methyl-1,3-dioxo-2-propan-2-ylpyrrolo[3,4-c]pyridin-4-yl)sulfanylphenyl]benzenesulfonamide
Show/Hide
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C24H22ClN3O4S2
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1
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| 1 |
EC50 = 224 nM
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CP0438246
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(1-methylcyclopropyl) 4-[(2R)-1-[[2-(2,3,6-trifluorophenyl)acetyl]amino]propan-2-yl]piperidine-1-carboxylate
Show/Hide
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C21H27F3N2O3
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1
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| 1 |
EC50 = 236 nM
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CP0543143
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N-(4-chlorophenyl)-3-(6-methyl-1,3-dioxo-2-propan-2-ylpyrrolo[3,4-c]pyridin-4-yl)oxybenzenesulfonamide
Show/Hide
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C23H20ClN3O5S
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1
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| 1 |
EC50 = 238 nM
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CP0386125
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2-methylpropyl 4-[4-[(2-fluoro-4-methylsulfonylanilino)methyl]pyrazol-1-yl]piperidine-1-carboxylate
Show/Hide
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C21H29FN4O4S
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1
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| 1 |
EC50 = 240 nM
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CP0470766
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propan-2-yl 4-[5-(2-fluoro-4-methylsulfonylphenyl)-4,6-dihydropyrrolo[3,4-c]pyrazol-2-yl]piperidine-1-carboxylate
Show/Hide
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C21H27FN4O4S
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1
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| 1 |
EC50 = 260 nM
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CP0421991
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5-[(3,3-dimethyl-2-oxaspiro[4.5]decan-8-yl)oxymethyl]-3-(3-fluoro-4-methylsulfonylphenyl)-1,2,4-oxadiazole
Show/Hide
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C21H27FN2O5S
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1
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| 1 |
EC50 = 261 nM
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CP0480369
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tert-butyl 4-[1-[[2-[4-(tetrazol-1-yl)phenyl]acetyl]amino]propan-2-yl]piperidine-1-carboxylate
Show/Hide
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C22H32N6O3
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1
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| 1 |
EC50 = 267 nM
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CP0416312
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3-chloro-4-[[6-[(9-cyclopropylsulfonyl-3-oxa-9-azabicyclo[3.3.1]nonan-7-yl)oxy]-5-methylpyrimidin-4-yl]amino]benzonitrile
Show/Hide
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C22H24ClN5O4S
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1
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| 1 |
EC50 = 268 nM
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CP0433406
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4-chloro-N-[3-(3-cyano-4,6-dimethylpyridin-2-yl)oxyphenyl]benzenesulfonamide
Show/Hide
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C20H16ClN3O3S
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1
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| 1 |
EC50 = 270 nM
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CP0380006
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5-[2-[[1-(4-chlorophenyl)sulfonyl-3,4-dihydro-2H-quinolin-7-yl]oxy]-6-methoxypyridin-4-yl]-3-cyclopropyl-1,2,4-oxadiazole
Show/Hide
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C26H23ClN4O5S
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1
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| 1 |
EC50 = 270 nM
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CP0458407
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2-[[7-[6-chloro-4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)pyridin-2-yl]oxy-3,4-dihydro-2H-quinolin-1-yl]sulfonyl]benzonitrile
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C26H20ClN5O4S
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1
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| 1 |
EC50 = 270 nM
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CP0465314
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propan-2-yl 6-[6-(4-cyano-2-fluorophenoxy)-5-methylpyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate
Show/Hide
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C24H26FN5O3
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1
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| 1 |
EC50 = 274 nM
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CP0439854
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5-[2-[[1-(benzenesulfonyl)-3,4-dihydro-2H-quinolin-7-yl]oxy]-6-chloropyridin-4-yl]-3-cyclopropyl-1,2,4-oxadiazole
Show/Hide
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C25H21ClN4O4S
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1
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| 1 |
EC50 = 290 nM
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CP0519743
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4-chloro-N-[3-(6-methyl-1,3-dioxo-2-phenylpyrrolo[3,4-c]pyridin-4-yl)oxyphenyl]benzenesulfonamide
Show/Hide
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C26H18ClN3O5S
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1
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| 1 |
EC50 = 299 nM
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CP0465308
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tert-butyl 6-[6-[2-fluoro-4-(3-methyl-1,2,4-triazol-1-yl)phenoxy]-5-methylpyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate
Show/Hide
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C27H32FN7O3
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1
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| 1 |
EC50 = 300 nM
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CP0477610
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4-chloro-N-[3-[6-chloro-4-(4-ethyl-1,2,4-triazol-3-yl)pyridin-2-yl]oxyphenyl]benzenesulfonamide
Show/Hide
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C21H17Cl2N5O3S
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1
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| 1 |
EC50 = 300 nM
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CP0550147
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3-[2,3-difluoro-4-(methylsulfonylmethyl)phenyl]-5-[(1R)-1-[(3,3-dimethyl-2-oxaspiro[4.5]decan-8-yl)oxy]ethyl]-1,2,4-oxadiazole
Show/Hide
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C23H30F2N2O5S
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1
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| 1 |
EC50 = 301 nM
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CP0477609
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N-[3-(3-cyano-4,6-dimethylpyridin-2-yl)oxyphenyl]-4-methylbenzenesulfonamide
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C21H19N3O3S
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1
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| 1 |
EC50 = 310 nM
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CP0380007
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7-chloro-6-[6-chloro-4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)pyridin-2-yl]oxy-4-(4-chlorophenyl)sulfonyl-2,3-dihydro-1lambda6,4-benzothiazine 1,1-dioxide
Show/Hide
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C24H17Cl3N4O6S2
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1
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| 1 |
EC50 = 310 nM
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CP0566087
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tert-butyl 6-[6-(4-methylsulfonylanilino)-5-nitropyrimidin-4-yl]oxy-2-azabicyclo[2.2.1]heptane-2-carboxylate
Show/Hide
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C22H27N5O7S
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1
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| 1 |
EC50 = 315 nM
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CP0411412
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5-[2-chloro-6-[[1-(3-fluorophenyl)sulfonyl-3,4-dihydro-2H-quinolin-7-yl]oxy]pyridin-4-yl]-3-cyclopropyl-1,2,4-oxadiazole
Show/Hide
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C25H20ClFN4O4S
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1
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| 1 |
EC50 = 320 nM
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CP0384161
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N,N-dimethyl-1-[5-[(3R)-2-oxo-3-[4-(1,3-thiazol-2-yl)phenoxy]pyrrolidin-1-yl]pyrimidin-2-yl]azetidine-3-carboxamide
Show/Hide
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C23H24N6O3S
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1
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| 1 |
EC50 = 324 nM
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CP0917213
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(1S,5S)-3-(5-methyl-6-(2-methylpyridin-3-yloxy)pyrimidin-4-yloxy)-8-(methylsulfonyl)-8-azabicyclo[3.2.1]octane
Show/Hide
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C19H24N4O4S
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1
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| 1 |
EC50 = 330 nM
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CP0498011
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US9469631, 49
Show/Hide
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C21H26FN5O3
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1
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| 1 |
EC50 = 338 nM
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CP0381425
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tert-butyl 4-[1-[[2-(3-fluorophenyl)acetyl]amino]propan-2-yl]piperidine-1-carboxylate
Show/Hide
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C21H31FN2O3
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1
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| 1 |
EC50 = 340 nM
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CP0407049
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N-tert-butyl-2-[3-[(4-chlorophenyl)sulfonylamino]phenoxy]-3-cyano-6-methylpyridine-4-carboxamide
Show/Hide
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C24H23ClN4O4S
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1
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| 1 |
EC50 = 350 nM
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CP0548334
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tert-butyl 4-[3-(4-methylsulfonylphenoxy)propyl]piperidine-1-carboxylate
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C20H31NO5S
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1
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| 1 |
EC50 = 353 nM
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CP0538324
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4-chloro-N-[3-fluoro-5-(6-methyl-1,3-dioxo-2-propan-2-ylpyrrolo[3,4-c]pyridin-4-yl)oxyphenyl]benzenesulfonamide
Show/Hide
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C23H19ClFN3O5S
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1
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| 1 |
EC50 = 357 nM
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CP0381098
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N-[3-(3-cyano-4,6-dimethylpyridin-2-yl)oxyphenyl]-4-(trifluoromethoxy)benzenesulfonamide
Show/Hide
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C21H16F3N3O4S
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1
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| 1 |
EC50 = 380 nM
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CP0433410
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N-[3-(3-cyano-4,6-dimethylpyridin-2-yl)oxyphenyl]-4-fluorobenzenesulfonamide
Show/Hide
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C20H16FN3O3S
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1
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| 1 |
EC50 = 380 nM
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CP0458440
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4-chloro-N-[2-methyl-5-[(6-methyl-1,3-dioxo-2-propan-2-ylpyrrolo[3,4-c]pyridin-4-yl)amino]phenyl]benzenesulfonamide
Show/Hide
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C24H23ClN4O4S
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1
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| 1 |
EC50 = 382 nM
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CP0389690
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N-methyl-N-[1-(4,5,6,7-tetrahydro-1,3-benzothiazol-2-ylmethyl)piperidin-4-yl]-2-[4-(tetrazol-1-yl)phenyl]acetamide
Show/Hide
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C23H29N7OS
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1
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| 1 |
EC50 = 396 nM
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CP0542591
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1-[5-Nitro-6-(4-[1,2,4]triazol-1-yl-phenylamino)-pyrimidin-4-yl]-piperidine-4-carboxylic acid ethyl ester
Show/Hide
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C20H22N8O4
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1
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| 1 |
EC50 = 400 nM
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CP0405127
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propan-2-yl 4-[2-[[2-(2,3,6-trifluorophenyl)acetyl]amino]ethyl]piperidine-1-carboxylate
Show/Hide
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C19H25F3N2O3
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1
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| 1 |
EC50 = 409 nM
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CP0384655
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CHEMBL4577659
Show/Hide
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C23H32N2O5S
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1
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| 1 |
EC50 = 426 nM
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CP0416624
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5-[(1S)-1-[(3,3-dimethyl-2-oxaspiro[4.5]decan-8-yl)oxy]ethyl]-3-[3-fluoro-4-(methylsulfonylmethyl)phenyl]-1,2,4-oxadiazole
Show/Hide
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C23H31FN2O5S
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1
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| 1 |
EC50 = 430 nM
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CP0407050
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N-[3-(3-cyano-4,6-dimethylpyridin-2-yl)oxyphenyl]-4-methoxybenzenesulfonamide
Show/Hide
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C21H19N3O4S
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1
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| 1 |
EC50 = 440 nM
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CP0073437
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N-methyl-N-[1-[[4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]methyl]piperidin-4-yl]-2-[4-(tetrazol-1-yl)phenyl]acetamide
Show/Hide
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C25H28N8O2
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1
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| 1 |
EC50 = 441 nM
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CP0510141
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2-chloro-6-[3-[(4-chlorophenyl)sulfonylamino]phenoxy]-N-cyclopropylpyridine-4-carboxamide
Show/Hide
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C21H17Cl2N3O4S
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1
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| 1 |
EC50 = 450 nM
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CP0272611
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N-methyl-2-(4-methylsulfonylphenyl)-N-[1-[[4-(trifluoromethyl)phenyl]methyl]piperidin-4-yl]acetamide
Show/Hide
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C23H27F3N2O3S
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1
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| 1 |
EC50 = 456 nM
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CP0538174
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[1-[5-[(3R)-2-oxo-3-[6-(2,2,2-trifluoroethoxy)pyridin-3-yl]oxypyrrolidin-1-yl]pyrimidin-2-yl]azetidin-3-yl] carbamate
Show/Hide
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C19H19F3N6O5
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1
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| 1 |
EC50 = 458 nM
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CP0417954
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cyclobutyl 4-[4-[(2-fluoro-4-methylsulfonylanilino)methyl]pyrazol-1-yl]piperidine-1-carboxylate
Show/Hide
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C21H27FN4O4S
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1
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| 1 |
EC50 = 462 nM
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CP0105307
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N-[(3S,4R)-3-fluoro-1-[[6-(trifluoromethyl)pyridin-3-yl]methyl]piperidin-4-yl]-N-methyl-2-[4-(tetrazol-1-yl)phenyl]acetamide
Show/Hide
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C22H23F4N7O
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1
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| 1 |
EC50 = 485 nM
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CP0342689
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N-methyl-4-[2-[methyl-[1-[[4-(trifluoromethyl)phenyl]methyl]piperidin-4-yl]amino]-2-oxoethyl]benzamide
Show/Hide
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C24H28F3N3O2
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1
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| 1 |
EC50 = 489 nM
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CP0414914
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4-chloro-N-[2-fluoro-3-(6-methyl-1,3-dioxo-2-propan-2-ylpyrrolo[3,4-c]pyridin-4-yl)oxyphenyl]benzenesulfonamide
Show/Hide
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C23H19ClFN3O5S
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1
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| 1 |
EC50 = 493 nM
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CP0470765
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5-[1-(5-ethylpyrimidin-2-yl)piperidin-4-yl]-2-(2-fluoro-4-methylsulfonylphenyl)-5-oxido-4,6-dihydropyrrolo[3,4-c]pyrazol-5-ium
Show/Hide
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C23H27FN6O3S
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1
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| 1 |
EC50 = 498 nM
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CP0893105
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(R)-((R)-tetrahydrofuran-3-yl)4-(5-((3-cyanopyridin-4-yl)methoxy)pyrimidin-2-yl)-3-methylpiperazine-1-carboxylate
Show/Hide
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C21H24N6O4
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1
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| 1 |
EC50 = 501.19 nM
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CP0467764
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4-[5-(2,2-dimethyl-1-oxaspiro[4.5]decan-8-yl)pentoxy]-N,N-dimethylbenzamide
Show/Hide
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C25H39NO3
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1
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| 1 |
EC50 = 511 nM
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CP0519813
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2-(4-acetamidophenyl)-N-methyl-N-[1-[[4-(trifluoromethyl)phenyl]methyl]piperidin-4-yl]acetamide
Show/Hide
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C24H28F3N3O2
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1
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| 1 |
EC50 = 535 nM
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CP0338487
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N-ethyl-2-(4-methylsulfonylphenyl)-N-[1-[[4-(trifluoromethyl)phenyl]methyl]piperidin-4-yl]acetamide
Show/Hide
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C24H29F3N2O3S
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1
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| 1 |
EC50 = 538 nM
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CP0421050
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5-[2-chloro-6-[[1-(3-chlorophenyl)sulfonyl-3,4-dihydro-2H-quinolin-7-yl]oxy]pyridin-4-yl]-3-cyclopropyl-1,2,4-oxadiazole
Show/Hide
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C25H20Cl2N4O4S
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1
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| 1 |
EC50 = 540 nM
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CP0431741
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3-[[7-[6-chloro-4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)pyridin-2-yl]oxy-3,4-dihydro-2H-quinolin-1-yl]sulfonyl]benzonitrile
Show/Hide
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C26H20ClN5O4S
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1
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| 1 |
EC50 = 550 nM
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CP0504369
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(5R)-tert-butyl 5-(5-methyl-6-(2-methylpyridin-3-yloxy)pyrimidin-4-yloxy)-2-azabicyclo[2.2.1]heptane-2-carboxylate
Show/Hide
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C22H28N4O4
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1
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| 1 |
EC50 = 558 nM
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CP0425701
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propan-2-yl 6-[5-methyl-6-(2-methylpyridin-3-yl)oxypyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate
Show/Hide
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C23H29N5O3
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1
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| 1 |
EC50 = 559 nM
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CP0430026
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5-[2-chloro-6-[[1-(3-methoxyphenyl)sulfonyl-3,4-dihydro-2H-quinolin-7-yl]oxy]pyridin-4-yl]-3-cyclopropyl-1,2,4-oxadiazole
Show/Hide
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C26H23ClN4O5S
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1
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| 1 |
EC50 = 590 nM
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CP0957894
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(R)-8-(3-aminopiperidin-1-yl)-7-(but-2-yn-1-yl)-3-methyl-1-(3-(4-(4-phenyl-1H-imidazol-2-yl)piperidin-l-yl)propyl)-1H-purine-2,6(3H,7H)-dione
Show/Hide
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C32H41N9O2
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1
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| 1 |
EC50 = 600 nM
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CP0411400
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2-[3-[(4-chlorophenyl)sulfonylamino]phenoxy]-3-cyano-N,N-diethyl-6-methylpyridine-4-carboxamide
Show/Hide
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C24H23ClN4O4S
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1
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| 1 |
EC50 = 610 nM
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CP0868780
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(R)-tetrahydro-2H-pyran-4-yl 4-(5-((3-cyanopyridin-4-yl)methoxy)pyrimidin-2-yl)-3-methylpiperazine-1-carboxylate
Show/Hide
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C22H26N6O4
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1
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| 1 |
EC50 = 630.96 nM
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CP0890134
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(R)-4-((2-(4-(5-(2-hydroxypropan-2-yl)-1,2,4-oxadiazol-3-yl)-2-methylpiperazin-1-yl)pyrimidin-5-yloxy)methyl)nicotinonitrile
Show/Hide
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C21H24N8O3
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1
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| 1 |
EC50 = 630.96 nM
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CP0386164
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(1-methylcyclopropyl) 6-[5-methyl-6-(2-methylpyridin-3-yl)oxypyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate
Show/Hide
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C24H29N5O3
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1
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| 1 |
EC50 = 636 nM
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CP0558146
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8-[(3R)-3-aminopiperidin-1-yl]-7-but-2-ynyl-3-methyl-1-[3-[4-(4-phenyl-1,3-thiazol-2-yl)piperazin-1-yl]propyl]purine-2,6-dione
Show/Hide
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C31H39N9O2S
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1
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| 1 |
EC50 = 650 nM
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CP0411401
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N-[3-(3-cyano-4,6-dimethylpyridin-2-yl)oxyphenyl]-4-ethylbenzenesulfonamide
Show/Hide
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C22H21N3O3S
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1
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| 1 |
EC50 = 660 nM
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CP0476792
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propan-2-yl 6-[5-methoxy-6-(2-methylpyridin-3-yl)oxypyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate
Show/Hide
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C23H29N5O4
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1
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| 1 |
EC50 = 691 nM
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CP0550146
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3-[3-fluoro-4-(methylsulfonylmethyl)phenyl]-5-[1-(1-oxaspiro[4.5]decan-8-yloxy)ethyl]-1,2,4-oxadiazole
Show/Hide
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C21H27FN2O5S
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1
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| 1 |
EC50 = 720 nM
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CP0421051
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5-[2-chloro-6-[[1-(4-methylsulfonylphenyl)sulfonyl-3,4-dihydro-2H-quinolin-7-yl]oxy]pyridin-4-yl]-3-cyclopropyl-1,2,4-oxadiazole
Show/Hide
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C26H23ClN4O6S2
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1
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| 1 |
EC50 = 770 nM
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CP0405125
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tert-butyl 4-[1-[[2-(2-fluorophenyl)acetyl]amino]propan-2-yl]piperidine-1-carboxylate
Show/Hide
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C21H31FN2O3
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1
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| 1 |
EC50 = 808 nM
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CP0378910
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N-[3-(3-cyano-4,6-dimethylpyridin-2-yl)oxyphenyl]-4-propan-2-ylbenzenesulfonamide
Show/Hide
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C23H23N3O3S
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1
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| 1 |
EC50 = 810 nM
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CP0569496
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8-[(3R)-3-aminopiperidin-1-yl]-7-but-2-ynyl-3-methyl-1-[3-[4-(5-phenyl-1,3-oxazol-2-yl)piperidin-1-yl]propyl]purine-2,6-dione
Show/Hide
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C32H40N8O3
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1
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| 1 |
EC50 = 830 nM
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CP0502605
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(5S)-tert-butyl 5-(5-methyl-6-(2-methylpyridin-3-yloxy)pyrimidin-4-yloxy)-2-azabicyclo[2.2.1]heptane-2-carboxylate
Show/Hide
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C22H28N4O4
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1
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| 1 |
EC50 = 860 nM
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CP0461201
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5-[2-chloro-6-[[1-(2,4-difluorophenyl)sulfonyl-3,4-dihydro-2H-quinolin-7-yl]oxy]pyridin-4-yl]-3-cyclopropyl-1,2,4-oxadiazole
Show/Hide
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C25H19ClF2N4O4S
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1
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| 1 |
EC50 = 860 nM
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CP0433413
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propan-2-yl 4-[2-(2-fluoro-4-methylsulfonylphenyl)-4,6-dihydropyrrolo[3,4-c]pyrazol-5-yl]piperidine-1-carboxylate
Show/Hide
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C21H27FN4O4S
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1
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| 1 |
EC50 = 864 nM
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CP0438283
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1-methylcyclopropyl 4-(2-(2-(2,3,6-trifluorophenyl)acetamido)ethyl)piperidine-1-carboxylate
Show/Hide
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C20H25F3N2O3
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1
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| 1 |
EC50 = 868 nM
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CP0381764
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tert-butyl 4-[1-[[2-(4-methylsulfonylphenyl)acetyl]amino]propan-2-yl]piperidine-1-carboxylate
Show/Hide
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C22H34N2O5S
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1
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| 1 |
EC50 = 884 nM
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CP0494361
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(1R,3S,5R)-8-(cyclopropylsulfonyl)-3-(5-methyl-6-(2-methylpyridin-3-yloxy)pyrimidin-4-yloxy)-8-azabicyclo[3.2.1]octan-6-one
Show/Hide
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C21H24N4O5S
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1
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| 1 |
EC50 = 918 nM
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CP0433405
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4-cyano-N-[3-(3-cyano-4,6-dimethylpyridin-2-yl)oxyphenyl]benzenesulfonamide
Show/Hide
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C21H16N4O3S
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1
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| 1 |
EC50 = 960 nM
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CP0528512
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1-{6-[4-(2-Methoxycarbonyl-acetyl)-phenoxy]-5-nitro-pyrimidin-4-yl}-piperidine-4-carboxylic acid ethyl ester
Show/Hide
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C22H24N4O8
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1
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| 1 |
EC50 = 1000 nM
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CP0417537
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tert-butyl 3-[4-(2-fluoro-4-methylsulfonylanilino)-6,7-dimethoxyquinazolin-2-yl]-3,9-diazabicyclo[4.2.1]nonane-9-carboxylate
Show/Hide
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C29H36FN5O6S
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1
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| 1 |
EC50 = 1000 nM
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CP0500396
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tert-butyl 3-[[[4-(2-fluoro-4-methylsulfonylanilino)-6,7-dimethoxyquinazolin-2-yl]amino]methyl]-8-azabicyclo[3.2.1]octane-8-carboxylate
Show/Hide
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C30H38FN5O6S
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1
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| 1 |
EC50 = 1000 nM
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CP0516986
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tert-butyl 3-[[4-(2-fluoro-4-methylsulfonylanilino)-6,7-dimethoxyquinazolin-2-yl]amino]-8-azabicyclo[3.2.1]octane-8-carboxylate
Show/Hide
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C29H36FN5O6S
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1
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| 1 |
EC50 = 1000 nM
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CP0535972
|
US9469631, 50
Show/Hide
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C21H25F2N5O3
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1
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| 1 |
EC50 = 1023 nM
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CP0449184
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(1-methylcyclopropyl) 6-[5-methoxy-6-(2-methylpyridin-3-yl)oxypyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate
Show/Hide
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C24H29N5O4
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1
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| 1 |
EC50 = 1028 nM
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CP0476798
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propan-2-yl 6-[6-[4-(dimethylcarbamoyl)-2-fluorophenoxy]-5-methylpyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate
Show/Hide
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C26H32FN5O4
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1
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| 1 |
EC50 = 1049 nM
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CP0407046
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4-chloro-N-[3-[6-chloro-4-(5-ethyl-1H-1,2,4-triazol-3-yl)pyridin-2-yl]oxyphenyl]benzenesulfonamide
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C21H17Cl2N5O3S
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1
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| 1 |
EC50 = 1060 nM
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CP0524608
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(1S,3S,5R)-8-(cyclopropylsulfonyl)-3-(5-methyl-6-(2-methylpyridin-3-yloxy)pyrimidin-4-yloxy)-8-azabicyclo[3.2.1]octan-6-ol
Show/Hide
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C21H26N4O5S
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1
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| 1 |
EC50 = 1150 nM
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CP0402242
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1-[6-(4-Methanesulfonyl-phenylamino)-5-nitro-pyrimidin-4-yl]-piperidine-4-carboxylic acid ethyl ester
Show/Hide
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C19H23N5O6S
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1
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| 1 |
EC50 = 1200 nM
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CP0949268
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(R)-((S)-tetrahydrofuran-3-yl)4-(5-((3-cyanopyridin-4-yl)methoxy)pyrimidin-2-yl)-3-methylpiperazine-1-carboxylate
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C21H24N6O4
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1
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| 1 |
EC50 = 1258.93 nM
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CP0517275
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N-methyl-2-[4-(tetrazol-1-yl)phenyl]-N-[1-[[5-(trifluoromethyl)pyridin-2-yl]methyl]piperidin-4-yl]acetamide
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C22H24F3N7O
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1
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| 1 |
EC50 = 1345 nM
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CP0381763
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(R)-1-methylcyclopropyl 4-(1-fluoro-2-(2-(2,3,6-trifluorophenyl)acetamido)ethyl)piperidine-1-carboxylate
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C20H24F4N2O3
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1
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| 1 |
EC50 = 1380 nM
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CP0516949
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8-[(3R)-3-aminopiperidin-1-yl]-7-but-2-ynyl-3-methyl-1-[3-[4-(3-phenyl-1,2,4-oxadiazol-5-yl)piperazin-1-yl]propyl]purine-2,6-dione
Show/Hide
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C30H38N10O3
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1
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| 1 |
EC50 = 1400 nM
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CP0556312
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8-[(3R)-3-aminopiperidin-1-yl]-7-but-2-ynyl-1-[3-[4-(5-fluoropyrimidin-2-yl)piperazin-1-yl]propyl]-3-methylpurine-2,6-dione
Show/Hide
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C26H35FN10O2
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1
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| 1 |
EC50 = 1410 nM
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CP0516950
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8-[(3R)-3-aminopiperidin-1-yl]-7-but-2-ynyl-3-methyl-1-[3-[4-(5-phenyl-1,2,4-oxadiazol-3-yl)piperazin-1-yl]propyl]purine-2,6-dione
Show/Hide
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C30H38N10O3
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1
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| 1 |
EC50 = 1450 nM
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CP0461200
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2-[2-chloro-6-[[1-(4-chlorophenyl)sulfonyl-3,4-dihydro-2H-quinolin-7-yl]oxy]pyridin-4-yl]-4-cyclopropyl-1,3-thiazole
Show/Hide
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C26H21Cl2N3O3S2
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1
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| 1 |
EC50 = 1500 nM
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CP0561675
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US9469631, 51
Show/Hide
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C23H30N4O3
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1
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| 1 |
EC50 = 1580 nM
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CP0893107
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(R)-oxetan-3-yl 4-(5-((3-cyanopyridin-4-yl)methoxy)pyrimidin-2-yl)-3-methylpiperazine-1-carboxylate
Show/Hide
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C20H22N6O4
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1
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| 1 |
EC50 = 1584.89 nM
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CP0378907
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N-[3-(3-cyano-4,6-dimethylpyridin-2-yl)oxyphenyl]-4-nitrobenzenesulfonamide
Show/Hide
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C20H16N4O5S
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1
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| 1 |
EC50 = 1600 nM
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CP0402243
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1-{5-Nitro-6-[4-(3-oxo-butyl)-phenoxy]-pyrimidin-4-yl}-piperidine-4-carboxylic acid ethyl ester
Show/Hide
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C22H26N4O6
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1
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| 1 |
EC50 = 1700 nM
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CP0397703
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4-chloro-N-[3-(3-cyano-6-methylpyridin-2-yl)oxyphenyl]benzenesulfonamide
Show/Hide
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C19H14ClN3O3S
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1
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| 1 |
EC50 = 1710 nM
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CP0516951
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8-[(3R)-3-aminopiperidin-1-yl]-7-but-2-ynyl-3-methyl-1-[3-[4-(5-propylpyrimidin-2-yl)piperazin-1-yl]propyl]purine-2,6-dione
Show/Hide
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C29H42N10O2
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1
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| 1 |
EC50 = 1850 nM
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CP0237668
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N-methyl-2-[4-(tetrazol-1-yl)phenyl]-N-[1-[[6-(trifluoromethyl)pyridin-3-yl]methyl]piperidin-4-yl]acetamide
Show/Hide
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C22H24F3N7O
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1
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| 1 |
EC50 = 1890 nM
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CP0481403
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1-[6-(4-Methanesulfonyl-phenoxy)-5-nitro-pyrimidin-4-yl]-piperidine-4-carboxylic acid ethyl ester
Show/Hide
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C19H22N4O7S
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1
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| 1 |
EC50 = 1900 nM
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CP0322222
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8-[(3R)-3-aminopiperidin-1-yl]-7-but-2-ynyl-3-methyl-1-[3-[4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazin-1-yl]propyl]purine-2,6-dione
Show/Hide
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C30H38N10O2S
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1
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| 1 |
EC50 = 1930 nM
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CP0411398
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4-chloro-N-[3-[3-cyano-6-cyclopropyl-4-(trifluoromethyl)pyridin-2-yl]oxyphenyl]benzenesulfonamide
Show/Hide
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C22H15ClF3N3O3S
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1
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| 1 |
EC50 = 2060 nM
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CP0847549
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(1S,5S)-8-(cyclopropylsulfonyl)-3-(5-methyl-6-(2-(trifluoromethyl)pyridin-3-yloxy)pyrimidin-4-yloxy)-8-azabicyclo[3.2.1]octane
Show/Hide
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C21H23F3N4O4S
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1
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| 1 |
EC50 = 2120 nM
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CP0446439
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4-chloro-N-[3-[3-cyano-6-(trifluoromethyl)pyridin-2-yl]oxyphenyl]benzenesulfonamide
Show/Hide
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C19H11ClF3N3O3S
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1
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| 1 |
EC50 = 2120 nM
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CP0035557
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(Z)-N-(2-hydroxyethyl)octadec-9-enamide
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C20H39NO2
|
1
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| 1 |
EC50 = 2200 nM
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CP0516952
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8-[(3R)-3-aminopiperidin-1-yl]-7-but-2-ynyl-1-[3-[4-(5-methoxypyrimidin-2-yl)piperazin-1-yl]propyl]-3-methylpurine-2,6-dione
Show/Hide
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C27H38N10O3
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1
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| 1 |
EC50 = 2260 nM
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CP0562936
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4-[5-[1-[(3,3-dimethyl-2-oxaspiro[4.5]decan-8-yl)oxy]ethyl]-1,2,4-oxadiazol-3-yl]-2-fluoro-N,N-dimethylbenzamide
Show/Hide
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C24H32FN3O4
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1
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| 1 |
EC50 = 2457 nM
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CP0554364
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1-[5-Nitro-6-(4-[1,2,4]triazol-1-yl-phenoxy)-pyrimidin-4-yl]-piperidine-4-carboxylic acid ethyl ester
Show/Hide
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C20H21N7O5
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1
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| 1 |
EC50 = 2500 nM
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CP0556313
|
8-[(3R)-3-aminopiperidin-1-yl]-7-but-2-ynyl-3-methyl-1-[3-[4-(5-methylpyrimidin-2-yl)piperazin-1-yl]propyl]purine-2,6-dione
Show/Hide
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C27H38N10O2
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1
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| 1 |
EC50 = 2560 nM
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CP0524607
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(6S)-tert-butyl 6-(5-methyl-6-(2-methylpyridin-3-yloxy)pyrimidin-4-yloxy)-2-azabicyclo[2.2.1]heptane-2-carboxylate
Show/Hide
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C22H28N4O4
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1
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| 1 |
EC50 = 2580 nM
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CP0500860
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2-[3-[(4-chlorophenyl)sulfonylamino]phenoxy]-3-cyano-6-methylpyridine-4-carboxylic acid
Show/Hide
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C20H14ClN3O5S
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1
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| 1 |
EC50 = 2740 nM
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CP0463893
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2-[3-[(4-chlorophenyl)sulfonylamino]phenoxy]-3-cyano-N,N,6-trimethylpyridine-4-carboxamide
Show/Hide
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C22H19ClN4O4S
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1
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| 1 |
EC50 = 2950 nM
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CP0402106
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1-[5-Nitro-6-(4-sulfamoyl-phenoxy)-pyrimidin-4-yl]-piperidine-4-carboxylic acid ethyl ester
Show/Hide
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C18H21N5O7S
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1
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| 1 |
EC50 = 3000 nM
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CP0556937
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8-[(3R)-3-aminopiperidin-1-yl]-7-but-2-ynyl-3-methyl-1-[3-[4-(4-phenyl-1,3-thiazol-2-yl)piperidin-1-yl]propyl]purine-2,6-dione
Show/Hide
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C32H40N8O2S
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1
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| 1 |
EC50 = 3130 nM
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CP0556311
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8-[(3R)-3-aminopiperidin-1-yl]-7-but-2-ynyl-1-[3-[4-(5-ethylpyrimidin-2-yl)piperazin-1-yl]propyl]-3-methylpurine-2,6-dione
Show/Hide
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C28H40N10O2
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1
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| 1 |
EC50 = 3990 nM
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CP0433409
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ethyl 6-tert-butyl-2-[3-[(4-chlorophenyl)sulfonylamino]phenoxy]-3-cyanopyridine-4-carboxylate
Show/Hide
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C25H24ClN3O5S
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1
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| 1 |
EC50 = 4000 nM
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CP0571756
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8-[(3R)-3-aminopiperidin-1-yl]-7-but-2-ynyl-3-methyl-1-[3-[4-[5-(trifluoromethyl)pyrimidin-2-yl]piperazin-1-yl]propyl]purine-2,6-dione
Show/Hide
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C27H35F3N10O2
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1
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| 1 |
EC50 = 4020 nM
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CP0429257
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5-[2-chloro-6-[[1-(4-chlorophenyl)sulfonyl-2,3,4,5-tetrahydro-1-benzazepin-8-yl]oxy]pyridin-4-yl]-3-cyclopropyl-1,2,4-oxadiazole
Show/Hide
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C26H22Cl2N4O4S
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1
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| 1 |
EC50 = 4300 nM
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CP0455150
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1-[5-[(3R)-3-[6-(cyclopropylmethoxy)pyridin-3-yl]oxy-2-oxopyrrolidin-1-yl]pyrimidin-2-yl]azetidine-3-carboxylic acid
Show/Hide
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C21H23N5O5
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1
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| 1 |
EC50 = 4920 nM
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CP0386161
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ethyl 6-[5-methyl-6-(2-methylpyridin-3-yl)oxypyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate
Show/Hide
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C22H27N5O3
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1
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| 1 |
EC50 = 5562 nM
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CP0405126
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tert-butyl 4-[1-[(2-phenylacetyl)amino]propan-2-yl]piperidine-1-carboxylate
Show/Hide
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C21H32N2O3
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1
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| 1 |
EC50 = 5980 nM
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CP0463894
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N-[3-(3-cyano-4,6-dimethylpyridin-2-yl)oxyphenyl]benzenesulfonamide
Show/Hide
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C20H17N3O3S
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1
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| 1 |
EC50 = 8400 nM
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CP0386124
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propan-2-yl 4-[4-[[(2-methyl-6-methylsulfonylpyridin-3-yl)amino]methyl]pyrazol-1-yl]piperidine-1-carboxylate
Show/Hide
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C20H29N5O4S
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1
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| 1 |
EC50 > 10000 nM
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CP0425702
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tert-butyl 6-[6-(2-methylpyridin-3-yl)oxypyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate
Show/Hide
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C23H29N5O3
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1
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| 1 |
EC50 > 10000 nM
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CP0465311
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(1-methylcyclopropyl) 6-[5-fluoro-6-(2-methylpyridin-3-yl)oxypyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate
Show/Hide
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C23H26FN5O3
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1
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| 1 |
EC50 > 10000 nM
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CP0465313
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(1-methylcyclopropyl) 6-[6-(2-methylpyridin-3-yl)oxypyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate
Show/Hide
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C23H27N5O3
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1
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| 1 |
EC50 > 10000 nM
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CP0947472
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Exo-tert-butyl 3-((6-(4-(methylsulfonyl)phenylamino)-5-nitropyrimidin-4-ylamino)methyl)-8-azabicyclo[3.2.1]octane-8-carboxylate
Show/Hide
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C24H32N6O6S
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1
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| 1 |
EC50 > 10000 nM
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CP0410688
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tert-butyl 4-[6,7-dimethoxy-2-(4-methylsulfonylanilino)quinazolin-4-yl]oxypiperidine-1-carboxylate
Show/Hide
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C27H34N4O7S
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1
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| 1 |
EC50 > 10000 nM
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CP0410689
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tert-butyl 3-[6,7-dimethoxy-2-(4-methylsulfonylanilino)quinazolin-4-yl]-3,9-diazabicyclo[4.2.1]nonane-9-carboxylate
Show/Hide
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C29H37N5O6S
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1
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| 1 |
EC50 > 10000 nM
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CP0410690
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4-(9-benzyl-3,9-diazabicyclo[4.2.1]nonan-3-yl)-6,7-dimethoxy-N-(4-methylsulfonylphenyl)quinazolin-2-amine
Show/Hide
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C31H35N5O4S
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1
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| 1 |
EC50 > 10000 nM
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CP0417531
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tert-butyl 4-[[6,7-dimethoxy-2-(4-methylsulfonylanilino)quinazolin-4-yl]oxymethyl]piperidine-1-carboxylate
Show/Hide
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C28H36N4O7S
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1
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| 1 |
EC50 > 10000 nM
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CP0417532
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tert-butyl 3-[6,7-dimethoxy-4-(4-methylsulfonylanilino)quinazolin-2-yl]-3,9-diazabicyclo[4.2.1]nonane-9-carboxylate
Show/Hide
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C29H37N5O6S
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1
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| 1 |
EC50 > 10000 nM
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CP0417534
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2-(9-benzyl-3,9-diazabicyclo[4.2.1]nonan-3-yl)-N-(2-fluoro-4-methylsulfonylphenyl)-6,7-dimethoxyquinazolin-4-amine
Show/Hide
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C31H34FN5O4S
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1
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| 1 |
EC50 > 10000 nM
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CP0417535
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tert-butyl 3-[[[6,7-dimethoxy-4-(4-methylsulfonylanilino)quinazolin-2-yl]amino]methyl]-8-azabicyclo[3.2.1]octane-8-carboxylate
Show/Hide
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C30H39N5O6S
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1
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| 1 |
EC50 > 10000 nM
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CP0425324
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tert-butyl 4-[[2-(2-fluoro-4-methylsulfonylanilino)-6,7-dimethoxyquinazolin-4-yl]oxymethyl]piperidine-1-carboxylate
Show/Hide
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C28H35FN4O7S
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1
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| 1 |
EC50 > 10000 nM
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CP0425325
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tert-butyl 4-[6,7-dimethoxy-4-(4-methylsulfonylanilino)quinazolin-2-yl]oxypiperidine-1-carboxylate
Show/Hide
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C27H34N4O7S
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1
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| 1 |
EC50 > 10000 nM
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CP0473346
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tert-butyl 4-[2-(2-fluoro-4-methylsulfonylanilino)-6,7-dimethoxyquinazolin-4-yl]oxypiperidine-1-carboxylate
Show/Hide
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C27H33FN4O7S
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1
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| 1 |
EC50 > 10000 nM
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CP0499766
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tert-butyl 3-[[[6,7-dimethoxy-2-(4-methylsulfonylanilino)quinazolin-4-yl]amino]methyl]-8-azabicyclo[3.2.1]octane-8-carboxylate
Show/Hide
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C30H39N5O6S
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1
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| 1 |
EC50 > 10000 nM
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CP0500394
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2-(9-benzyl-3,9-diazabicyclo[4.2.1]nonan-3-yl)-6,7-dimethoxy-N-(4-methylsulfonylphenyl)quinazolin-4-amine
Show/Hide
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C31H35N5O4S
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1
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| 1 |
EC50 > 10000 nM
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CP0500395
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tert-butyl 4-[4-(2-fluoro-4-methylsulfonylanilino)-6,7-dimethoxyquinazolin-2-yl]oxypiperidine-1-carboxylate
Show/Hide
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C27H33FN4O7S
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1
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| 1 |
EC50 > 10000 nM
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CP0540439
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tert-butyl 3-[[6,7-dimethoxy-2-(4-methylsulfonylanilino)quinazolin-4-yl]amino]-8-azabicyclo[3.2.1]octane-8-carboxylate
Show/Hide
|
C29H37N5O6S
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1
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| 1 |
EC50 > 10000 nM
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CP0540440
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tert-butyl 4-[[4-(2-fluoro-4-methylsulfonylanilino)-6,7-dimethoxyquinazolin-2-yl]oxymethyl]piperidine-1-carboxylate
Show/Hide
|
C28H35FN4O7S
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1
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| 1 |
EC50 > 10000 nM
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CP0538794
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tert-butyl 5-[6-(2-fluoro-4-methylsulfonylanilino)-5-nitropyrimidin-4-yl]oxy-2-azabicyclo[2.2.2]octane-2-carboxylate
Show/Hide
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C23H28FN5O7S
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1
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| 1 |
EC50 > 10000 nM
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CP0509512
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(6R)-tert-butyl 6-(5-methyl-6-(2-methylpyridin-3-yloxy)pyrimidin-4-yloxy)-2-azabicyclo[2.2.1]heptane-2-carboxylate
Show/Hide
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C22H28N4O4
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1
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| 1 |
EC50 > 20000 nM
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CP0847539
|
(1R,5R)-7-[5-Methyl-6-(2-methyl-pyridin-3-yloxy)-pyrimidin-4-yloxy]-9-aza-tricyclo[3.3.1.0*2,4*]nonane-9-carboxylic acid isopropyl ester
Show/Hide
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C23H28N4O4
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1
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| 1 |
EC50 > 30000 nM
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CP0342688
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N-methyl-2-phenyl-N-[1-[[4-(trifluoromethyl)phenyl]methyl]piperidin-4-yl]acetamide
Show/Hide
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C22H25F3N2O
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1
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| 1 |
EC50 > 30000 nM
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CP0415461
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4-chloro-N-[3-(6-methyl-1,3-dioxo-2-propan-2-ylpyrrolo[3,4-c]pyridin-4-yl)oxyphenyl]benzamide
Show/Hide
|
C24H20ClN3O4
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1
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| 1 |
EC50 > 30000 nM
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CP0431726
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6-[[1-(4-chlorophenyl)sulfonyl-3,4-dihydro-2H-quinolin-7-yl]oxy]-4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-1H-pyridin-2-one
Show/Hide
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C25H21ClN4O5S
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1
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| 1 |
EC50 > 30000 nM
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CP0425216
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1-[6-[(3,3-dimethyl-2-oxaspiro[4.5]decan-8-yl)oxy]-5-methylpyrimidin-4-yl]-5-methylsulfonyl-2,3-dihydroindole
Show/Hide
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C25H33N3O4S
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1
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| 1 |
EC50 > 1000 nM
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CP0534715
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6-[(3,3-dimethyl-2-oxaspiro[4.5]decan-8-yl)oxy]-N-(2-fluoro-4-methylsulfonylphenyl)-N,5-dimethylpyrimidin-4-amine
Show/Hide
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C24H32FN3O4S
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1
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| 1 |
EC50 > 1000 nM
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CP0388324
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6-N-(2-fluoro-4-methylsulfonylphenyl)-4-N-[(1R,5R)-8-methylsulfonyl-8-azabicyclo[3.2.1]octan-3-yl]-5-nitropyrimidine-4,6-diamine
Show/Hide
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C19H23FN6O6S2
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1
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| 1 |
EC50 > 2000 nM
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CP0388325
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cyclopropylmethyl (1R,5R)-3-[6-(2-fluoro-4-methylsulfonylanilino)-5-nitropyrimidin-4-yl]oxy-8-azabicyclo[3.2.1]octane-8-carboxylate
Show/Hide
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C23H26FN5O7S
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1
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| 1 |
EC50 > 2000 nM
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CP0388326
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cyclopropylmethyl (1R,5R)-3-[[6-(2-fluoro-4-methylsulfonylanilino)-5-nitropyrimidin-4-yl]amino]-8-azabicyclo[3.2.1]octane-8-carboxylate
Show/Hide
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C23H27FN6O6S
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1
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| 1 |
EC50 > 2000 nM
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CP0463846
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6-N-(2-fluoro-4-methylsulfonylphenyl)-4-N-[(1R,5R)-8-(4-fluorophenyl)sulfonyl-8-azabicyclo[3.2.1]octan-3-yl]-5-nitropyrimidine-4,6-diamine
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C24H24F2N6O6S2
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1
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| 1 |
EC50 > 2000 nM
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CP0463849
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tert-butyl (1R,5R)-3-[[6-(2-cyanoanilino)-5-nitropyrimidin-4-yl]amino]-8-azabicyclo[3.2.1]octane-8-carboxylate
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C23H27N7O4
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1
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| 1 |
EC50 > 2000 nM
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CP0469171
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ethyl (1R,5R)-3-[[6-(2-fluoro-4-methylsulfonylanilino)-5-nitropyrimidin-4-yl]amino]-8-azabicyclo[3.2.1]octane-8-carboxylate
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C21H25FN6O6S
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1
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| 1 |
EC50 > 2000 nM
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CP0508442
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tert-butyl (1R,5R)-3-[[6-(2-chlorophenoxy)-5-nitropyrimidin-4-yl]amino]-8-azabicyclo[3.2.1]octane-8-carboxylate
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C22H26ClN5O5
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1
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| 1 |
EC50 > 2000 nM
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CP0465310
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tert-butyl 6-[5-fluoro-6-(2-methylpyridin-3-yl)oxypyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate
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C23H28FN5O3
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1
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| 1 |
EC50 > 3014 nM
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CP0910252
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(1S,5S)-8-(isopropylsulfonyl)-3-(5-methyl-6-(2-methylpyridin-3-yloxy)pyrimidin-4-yloxy)-8-azabicyclo[3.2.1]octane
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C21H28N4O4S
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1
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| 1 |
EC50 > 5000 nM
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CP0386159
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tert-butyl 6-[5-methyl-6-[4-(3-methyl-1,2,4-triazol-1-yl)phenoxy]pyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate
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C27H33N7O3
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1
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| 1 |
EC50 > 8510 nM
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CP0554361
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1-[6-(4-bromo-phenoxy)-5-nitro-pyrimidin-4-yl]-piperidine-4-carboxylic acid ethyl ester
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C18H19BrN4O5
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1
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| 1 |
IC50 = 50 nM
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CP0529643
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ethyl 1-[6-[2-methyl-5-(trifluoromethyl)pyrazol-3-yl]oxy-5-nitropyrimidin-4-yl]piperidine-4-carboxylate
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C17H19F3N6O5
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1
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| 1 |
IC50 = 84 nM
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CP0542592
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ethyl 1-[6-[4-(2-methoxyethoxy)phenoxy]-5-nitropyrimidin-4-yl]piperidine-4-carboxylate
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C21H26N4O7
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1
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| 1 |
IC50 = 500 nM
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