General Information of the Compound
Compound ID
CP0429257
Compound Name
5-[2-chloro-6-[[1-(4-chlorophenyl)sulfonyl-2,3,4,5-tetrahydro-1-benzazepin-8-yl]oxy]pyridin-4-yl]-3-cyclopropyl-1,2,4-oxadiazole
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Structure
Formula
C26H22Cl2N4O4S
Molecular Weight
557.459
Canonical SMILES
Clc1ccc(cc1)S(=O)(=O)N1CCCCc2ccc(Oc3cc(cc(Cl)n3)-c3nc(no3)C3CC3)cc12
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InChI
InChI=1S/C26H22Cl2N4O4S/c27-19-7-10-21(11-8-19)37(33,34)32-12-2-1-3-16-6-9-20(15-22(16)32)35-24-14-18(13-23(28)29-24)26-30-25(31-36-26)17-4-5-17/h6-11,13-15,17H,1-5,12H2
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InChIKey
JQHVSUQVTZTZSV-UHFFFAOYSA-N
Physicochemical Property
logP
6.6397
Rotatable Bonds
6
Heavy Atom Count
37
Polar Areas
98.42
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
7
Complexity
37

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 76321324
ChEMBL ID
CHEMBL3113003
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02455, Glucose-dependent insulinotropic receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
EC50 = 4300 nM
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