General Information of the Compound
Compound ID
CP0425682
Compound Name
(5-ethylpyrimidin-2-yl) 4-[4-[(2-fluoro-4-methylsulfonylanilino)methyl]pyrazol-1-yl]piperidine-1-carboxylate
    Show/Hide
Structure
Formula
C23H27FN6O4S
Molecular Weight
502.572
Canonical SMILES
CCc1cnc(OC(=O)N2CCC(CC2)n2cc(CNc3ccc(cc3F)S(C)(=O)=O)cn2)nc1
    Show/Hide
InChI
InChI=1S/C23H27FN6O4S/c1-3-16-11-26-22(27-12-16)34-23(31)29-8-6-18(7-9-29)30-15-17(14-28-30)13-25-21-5-4-19(10-20(21)24)35(2,32)33/h4-5,10-12,14-15,18,25H,3,6-9,13H2,1-2H3
    Show/Hide
InChIKey
UIGMXUHDQDBMNZ-UHFFFAOYSA-N
Physicochemical Property
logP
3.2261
Rotatable Bonds
7
Heavy Atom Count
35
Polar Areas
119.31
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
9
Complexity
35

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 71716738
ChEMBL ID
CHEMBL2313409
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02455, Glucose-dependent insulinotropic receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
EC50 = 47 nM
   TI
   LI
   LO
   TS