General Information of the Compound
Compound ID
CP0476792
Compound Name
propan-2-yl 6-[5-methoxy-6-(2-methylpyridin-3-yl)oxypyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate
    Show/Hide
Structure
Formula
C23H29N5O4
Molecular Weight
439.516
Canonical SMILES
COc1c(Oc2cccnc2C)ncnc1N1C2CC3CC1CC(C2)N3C(=O)OC(C)C
    Show/Hide
InChI
InChI=1S/C23H29N5O4/c1-13(2)31-23(29)28-17-8-15-9-18(28)11-16(10-17)27(15)21-20(30-4)22(26-12-25-21)32-19-6-5-7-24-14(19)3/h5-7,12-13,15-18H,8-11H2,1-4H3
    Show/Hide
InChIKey
YGXXZFLKCGZDIF-UHFFFAOYSA-N
Physicochemical Property
logP
3.70992
Rotatable Bonds
5
Heavy Atom Count
32
Polar Areas
89.91
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
8
Complexity
32

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 71546200
ChEMBL ID
CHEMBL2312509
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02455, Glucose-dependent insulinotropic receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
EC50 = 691 nM
   TI
   LI
   LO
   TS
CL000524 HEK293-FT Homo sapiens (Human)  1
1
Ki = 1496 nM
   TI
   LI
   LO
   TS