General Information of the Compound
Compound ID
CP0564956
Compound Name
5-[(3R)-3-[6-(cyclopropylmethoxy)pyridin-3-yl]oxy-2-oxopyrrolidin-1-yl]-2-(3-hydroxyazetidin-1-yl)pyridine-3-carbonitrile
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Structure
Formula
C22H23N5O4
Molecular Weight
421.457
Canonical SMILES
OC1CN(C1)c1ncc(cc1C#N)N1CC[C@@H](Oc2ccc(OCC3CC3)nc2)C1=O
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InChI
InChI=1S/C22H23N5O4/c23-8-15-7-16(9-25-21(15)26-11-17(28)12-26)27-6-5-19(22(27)29)31-18-3-4-20(24-10-18)30-13-14-1-2-14/h3-4,7,9-10,14,17,19,28H,1-2,5-6,11-13H2/t19-/m1/s1
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InChIKey
OTBCPISSYHSVIX-LJQANCHMSA-N
Physicochemical Property
logP
1.50228
Rotatable Bonds
7
Heavy Atom Count
31
Polar Areas
111.81
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
8
Complexity
31

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 139437017
ChEMBL ID
CHEMBL4537090
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02455, Glucose-dependent insulinotropic receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
EC50 = 57 nM
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