General Information of the Compound
Compound ID
CP0386157
Compound Name
propan-2-yl 6-[5-methyl-6-[4-(tetrazol-1-yl)phenoxy]pyrimidin-4-yl]-2,6-diazatricyclo[3.3.1.13,7]decane-2-carboxylate
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Structure
Formula
C24H28N8O3
Molecular Weight
476.541
Canonical SMILES
CC(C)OC(=O)N1C2CC3CC1CC(C2)N3c1ncnc(Oc2ccc(cc2)-n2cnnn2)c1C
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InChI
InChI=1S/C24H28N8O3/c1-14(2)34-24(33)32-19-8-17-9-20(32)11-18(10-19)31(17)22-15(3)23(26-12-25-22)35-21-6-4-16(5-7-21)30-13-27-28-29-30/h4-7,12-14,17-20H,8-11H2,1-3H3
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InChIKey
XJVIXQWGMYJCSJ-UHFFFAOYSA-N
Physicochemical Property
logP
3.28202
Rotatable Bonds
5
Heavy Atom Count
35
Polar Areas
111.39
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
10
Complexity
35

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 71546855
ChEMBL ID
CHEMBL2312515
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02455, Glucose-dependent insulinotropic receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
EC50 = 100 nM
   TI
   LI
   LO
   TS
CL000524 HEK293-FT Homo sapiens (Human)  1
1
Ki = 94 nM
   TI
   LI
   LO
   TS