General Information of the Compound
Compound ID
CP0529643
Compound Name
ethyl 1-[6-[2-methyl-5-(trifluoromethyl)pyrazol-3-yl]oxy-5-nitropyrimidin-4-yl]piperidine-4-carboxylate
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Structure
Formula
C17H19F3N6O5
Molecular Weight
444.37
Canonical SMILES
CCOC(=O)C1CCN(CC1)c1ncnc(Oc2cc(nn2C)C(F)(F)F)c1[N+]([O-])=O
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InChI
InChI=1S/C17H19F3N6O5/c1-3-30-16(27)10-4-6-25(7-5-10)14-13(26(28)29)15(22-9-21-14)31-12-8-11(17(18,19)20)23-24(12)2/h8-10H,3-7H2,1-2H3
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InChIKey
GZORJFSITDOUIP-UHFFFAOYSA-N
Physicochemical Property
logP
2.7089
Rotatable Bonds
6
Heavy Atom Count
31
Polar Areas
125.51
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
10
Complexity
31

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 3766553
SID: 15502474
ChEMBL ID
CHEMBL461765
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02455, Glucose-dependent insulinotropic receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 84 nM
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