General Information of the Compound
Compound ID
CP0402242
Compound Name
1-[6-(4-Methanesulfonyl-phenylamino)-5-nitro-pyrimidin-4-yl]-piperidine-4-carboxylic acid ethyl ester
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Structure
Formula
C19H23N5O6S
Molecular Weight
449.489
Canonical SMILES
CCOC(=O)C1CCN(CC1)c1ncnc(Nc2ccc(cc2)S(C)(=O)=O)c1[N+]([O-])=O
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InChI
InChI=1S/C19H23N5O6S/c1-3-30-19(25)13-8-10-23(11-9-13)18-16(24(26)27)17(20-12-21-18)22-14-4-6-15(7-5-14)31(2,28)29/h4-7,12-13H,3,8-11H2,1-2H3,(H,20,21,22)
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InChIKey
NMFLPNKHJXTHLM-UHFFFAOYSA-N
Physicochemical Property
logP
2.3114
Rotatable Bonds
7
Heavy Atom Count
31
Polar Areas
144.63
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
10
Complexity
31

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 25052970
SID: 56389174
ChEMBL ID
CHEMBL451797
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02455, Glucose-dependent insulinotropic receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
EC50 = 1200 nM
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