General Information of the Compound
Compound ID
CP0433407
Compound Name
4-chloro-N-[3-[6-chloro-4-(3-propan-2-yl-1,2,4-oxadiazol-5-yl)pyridin-2-yl]oxyphenyl]benzenesulfonamide
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Structure
Formula
C22H18Cl2N4O4S
Molecular Weight
505.383
Canonical SMILES
CC(C)c1noc(n1)-c1cc(Cl)nc(Oc2cccc(NS(=O)(=O)c3ccc(Cl)cc3)c2)c1
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InChI
InChI=1S/C22H18Cl2N4O4S/c1-13(2)21-26-22(32-27-21)14-10-19(24)25-20(11-14)31-17-5-3-4-16(12-17)28-33(29,30)18-8-6-15(23)7-9-18/h3-13,28H,1-2H3
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InChIKey
XMEYRMWCLMWUFX-UHFFFAOYSA-N
Physicochemical Property
logP
6.1549
Rotatable Bonds
7
Heavy Atom Count
33
Polar Areas
107.21
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
7
Complexity
33

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 71655315
ChEMBL ID
CHEMBL2391601
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02455, Glucose-dependent insulinotropic receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  2
1
EC50 = 20 nM
   TI
   LI
   LO
   TS
2
EC50 = 24 nM
   TI
   LI
   LO
   TS