| Compound ID |
Compound Name |
Compound Formula |
|
CP0043589
|
(13S,17S)-13-Methyl-7-[9-(4,4,5,5,5-pentafluoro-pentane-1-sulfinyl)-nonyl]-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol
Show/Hide
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C32H47F5O3S
|
12
|
| 1 |
Activity = 0.1 nM
|
|
|
| 2 |
EC50 = 0.4 nM
|
|
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| 3 |
IC50 = 0.06 nM
|
|
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| 4 |
IC50 = 0.0631 nM
|
|
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| 5 |
IC50 = 0.3 nM
|
|
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| 6 |
IC50 = 0.32 nM
|
|
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| 7 |
IC50 = 0.47 nM
|
|
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| 8 |
IC50 = 1 nM
|
|
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| 9 |
IC50 = 1.2 nM
|
|
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| 10 |
IC50 = 3.4 nM
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|
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| 11 |
IC50 = 3.8 nM
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|
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| 12 |
IC50 = 5.012 nM
|
|
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CP0648741
|
4-Hydroxytamoxifen
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|
C26H29NO2
|
3
|
| 1 |
Activity = 0.1 nM
|
|
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| 2 |
IC50 = 3 nM
|
|
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| 3 |
IC50 = 4897.79 nM
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CP0156584
|
2-(4-Hydroxy-phenyl)-3-methyl-1-[4-(2-piperidin-1-yl-ethoxy)-benzyl]-1H-indol-5-ol
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|
C29H32N2O3
|
1
|
| 1 |
EC50 = 0.1 nM
|
|
|
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CP0959160
|
1-(3,5-Difluoro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenyl)azetidine-3-carboxamide
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|
C26H29F3N4O
|
1
|
| 1 |
EC50 = 0.1 nM
|
|
|
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CP0095089
|
2-(4-methoxyphenyl)-3-[4-(2-piperidin-1-ylethoxy)phenoxy]-1-benzothiophen-6-ol
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|
C28H29NO4S
|
1
|
| 1 |
EC50 = 0.2 nM
|
|
|
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CP0445896
|
6-(4- chloro-2- fluoro- phenyl)-5- [4-[(3S)-1- (3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2-ol
Show/Hide
|
C30H30ClF2NO2
|
1
|
| 1 |
EC50 = 0.2 nM
|
|
|
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CP0450720
|
5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-6-(4- pyridyl)- 8,9- dihydro- 7H- benzo[7]- annulen-2-ol
Show/Hide
|
C29H31FN2O2
|
1
|
| 1 |
EC50 = 0.2 nM
|
|
|
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CP0481791
|
7-(4-hydroxyphenyl)-8-[4-(1-propylazetidin-3-yl)oxyphenyl]-5,6-dihydronaphthalen-2-ol
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|
C28H29NO3
|
1
|
| 1 |
EC50 = 0.2 nM
|
|
|
|
CP0491461
|
6-(2,4-dichlorophenyl)-5-[4-[(3S)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7H-benzo[7]annulene-2-carboxylic acid
Show/Hide
|
C31H30Cl2FNO3
|
2
|
| 1 |
EC50 = 0.2 nM
|
|
|
| 2 |
EC50 = 1.2 nM
|
|
|
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CP0491462
|
5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-6-(3- pyridyl)- 8,9- dihydro- 7H- benzo[7]- annulen-2-ol
Show/Hide
|
C29H31FN2O2
|
1
|
| 1 |
EC50 = 0.2 nM
|
|
|
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CP0966645
|
(1R,3R)-1-(2,6-Difluoro-4-(3-(fluoromethyl)azetidin-1-yl)phenyl)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1Hpyrido[3,4-b]indole
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|
C26H29F4N3
|
1
|
| 1 |
EC50 = 0.22 nM
|
|
|
|
CP0572051
|
(E)-3-[3,5-difluoro-4-[(1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-1,3,4,4a,9,9a-hexahydropyrido[3,4-b]indol-1-yl]phenyl]prop-2-enoic acid
Show/Hide
|
C25H27F3N2O2
|
1
|
| 1 |
EC50 = 0.23 nM
|
|
|
|
CP0960902
|
6-(3,5-Difluoro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenyl)-2-oxa-6-azaspiro[3.3]heptane
Show/Hide
|
C27H30F3N3O
|
1
|
| 1 |
EC50 = 0.23 nM
|
|
|
|
CP0959159
|
3',5'-Difluoro-4'-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)-3-methoxy-[1,1'-biphenyl]-4-carboxylic Acid
Show/Hide
|
C30H29F3N2O3
|
1
|
| 1 |
EC50 = 0.25 nM
|
|
|
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CP0965953
|
1-(3,5-Difluoro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenyl)-1H-pyrazole-4-carboxylic Acid
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|
C26H25F3N4O2
|
1
|
| 1 |
EC50 = 0.26 nM
|
|
|
|
CP0402178
|
US9714221, Example 4
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|
C30H30ClF2NO2
|
1
|
| 1 |
EC50 = 0.3 nM
|
|
|
|
CP0479477
|
8-[4-[(3S)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-7-(4-hydroxyphenyl)-5,6-dihydronaphthalen-2-ol
Show/Hide
|
C29H30FNO3
|
1
|
| 1 |
EC50 = 0.3 nM
|
|
|
|
CP0547890
|
6-(2- chloro-4- fluoro- phenyl)-5- [4-[(3S)-1- (3-fluoro- propyl)- pyrrolidin-3- yl]oxy- phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2-ol
Show/Hide
|
C30H30ClF2NO2
|
1
|
| 1 |
EC50 = 0.3 nM
|
|
|
|
CP0576337
|
(E)-3-[4-[(E)-2-(2-chloro-4-methoxyphenyl)-2-cyclobutyl-1-imidazo[1,2-a]pyridin-6-ylethenyl]phenyl]prop-2-enoic acid
Show/Hide
|
C29H25ClN2O3
|
1
|
| 1 |
EC50 = 0.3 nM
|
|
|
|
CP0967353
|
3',5'-Difluoro-4'-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)-[1,1'-biphenyl]-4-carboxylic Acid
Show/Hide
|
C29H27F3N2O2
|
1
|
| 1 |
EC50 = 0.3 nM
|
|
|
|
CP0969484
|
6-(3-Fluoro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)-5-methoxyphenyl)-nicotinic Acid
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|
C29H29F2N3O3
|
1
|
| 1 |
EC50 = 0.34 nM
|
|
|
|
CP0968875
|
(E)-3-(3,5-Difluoro-4-((5R)-4-(2-fluoro-2-methylpropyl)-1,2,3,3a,4,5,6,10c-octahydrocyclopenta[5,6]pyrido[3,4-b]indol-5-yl)phenyl)acrylic Acid
Show/Hide
|
C27H27F3N2O2
|
1
|
| 1 |
EC50 = 0.35 nM
|
|
|
|
CP0547892
|
US9714221, Example 1
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|
C30H32FNO3
|
1
|
| 1 |
EC50 = 0.4 nM
|
|
|
|
CP0533848
|
(E)-3-[4-[(E)-1-(1,3-benzothiazol-5-yl)-2-(2-chloro-4-methoxyphenyl)-2-cyclobutylethenyl]phenyl]prop-2-enoic acid
Show/Hide
|
C29H24ClNO3S
|
1
|
| 1 |
EC50 = 0.4 nM
|
|
|
|
CP0567447
|
(E)-3-[4-[(E)-1-(1,3-benzothiazol-5-yl)-2-(4-chloro-2-cyanophenyl)-2-cyclobutylethenyl]phenyl]prop-2-enoic acid
Show/Hide
|
C29H21ClN2O2S
|
1
|
| 1 |
EC50 = 0.4 nM
|
|
|
|
CP0551988
|
2-[2-(1,1-difluoroethyl)-4-fluorophenyl]-3-[4-[1-(3-fluoropropyl)azetidin-3-yl]oxy-3-methoxyphenoxy]-6H-thieno[2,3-e]indazole
Show/Hide
|
C30H27F4N3O3S
|
1
|
| 1 |
EC50 = 0.4 nM
|
|
|
|
CP0579605
|
2-[1-[2-[4-[[2-[2-(1,1-difluoroethyl)-4-fluorophenyl]-6H-thieno[2,3-e]indazol-3-yl]oxy]phenoxy]ethyl]azetidin-3-yl]acetonitrile
Show/Hide
|
C30H25F3N4O2S
|
1
|
| 1 |
EC50 = 0.4 nM
|
|
|
|
CP0960905
|
3'-Chloro-5'-fluoro-4'-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)-3-methoxy-[1,1'-biphenyl]-4-carboxylic Acid
Show/Hide
|
C30H29ClF2N2O3
|
1
|
| 1 |
EC50 = 0.43 nM
|
|
|
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CP0960883
|
(E)-3-(3-Fluoro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)-5-methoxyphenyl)-acrylic Acid
Show/Hide
|
C26H28F2N2O3
|
1
|
| 1 |
EC50 = 0.48 nM
|
|
|
|
CP0968118
|
5-(3,5-Difluoro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenyl)thiazole-2-carboxylic Acid
Show/Hide
|
C26H24F3N3O2S
|
1
|
| 1 |
EC50 = 0.49 nM
|
|
|
|
CP0494093
|
(E)-3-[4-[(E)-1-(1H-indazol-5-yl)-2-(4-methylthiophen-3-yl)but-1-enyl]phenyl]prop-2-enoic acid
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|
C25H22N2O2S
|
1
|
| 1 |
EC50 = 0.5 nM
|
|
|
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CP0445895
|
6-(3-chloro-2-fluoro-phenyl)-5-[4-[(3S)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7H-benzo[7]annulen-2-ol
Show/Hide
|
C30H30ClF2NO2
|
1
|
| 1 |
EC50 = 0.5 nM
|
|
|
|
CP0466435
|
9-(4-{[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy}- phenyl]-8- phenyl- 6,7- dihydro- 5H- benzo[7]- annulen-3-ol5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-6-(1H- indazol-5- yl)-8,9- dihydro- 7H- benzo[7]- annulen-2-ol
Show/Hide
|
C30H32FNO2
|
1
|
| 1 |
EC50 = 0.5 nM
|
|
|
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CP0557236
|
6-(2- chloro-3- fluoro- phenyl)-5- [4-[(3S)-1- (3-fluoro- propyl)- pyrrolidin-3- yl]oxyphenyl]- 8,9-dihydro- 7H- benzo[7]- annulen-2-ol6-(2-fluoro- 4-methyl- phenyl)-5- [4-[(3S)-1- (3- fluoropropyl)- pyrrolidin- 3-yl]oxy- phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2-ol
Show/Hide
|
C30H30ClF2NO2
|
1
|
| 1 |
EC50 = 0.5 nM
|
|
|
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CP0859669
|
5-[4-[(3S)-1-(3-Fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-6-(1H-indol-5-yl)-8,9-dihydro-7H-benzo[7]annulen-2-ol
Show/Hide
|
C32H33FN2O2
|
1
|
| 1 |
EC50 = 0.5 nM
|
|
|
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CP0950273
|
6-(3,5-Difluoro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenyl)nicotinic Acid
Show/Hide
|
C28H26F3N3O2
|
1
|
| 1 |
EC50 = 0.5 nM
|
|
|
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CP0967899
|
1-(3,5-Difluoro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenyl)azetidine-3-carboxylic Acid
Show/Hide
|
C26H28F3N3O2
|
1
|
| 1 |
EC50 = 0.53 nM
|
|
|
|
CP0967351
|
3',5'-Difluoro-4'-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)-2-methoxy-[1,1'-biphenyl]-4-carboxylic Acid
Show/Hide
|
C30H29F3N2O3
|
1
|
| 1 |
EC50 = 0.54 nM
|
|
|
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CP0969280
|
1-(3,5-Difluoro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenyl)azetidine-3-carbonitrile
Show/Hide
|
C26H27F3N4
|
1
|
| 1 |
EC50 = 0.55 nM
|
|
|
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CP0960904
|
3',5'-Dichloro-4'-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)-3-methoxy-[1,1'-biphenyl]-4-carboxylic Acid
Show/Hide
|
C30H29Cl2FN2O3
|
1
|
| 1 |
EC50 = 0.58 nM
|
|
|
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CP0466436
|
7-(4-hydroxyphenyl)-8-[4-[(3S)-1-propylpyrrolidin-3-yl]oxyphenyl]-5,6-dihydronaphthalen-2-ol
Show/Hide
|
C29H31NO3
|
1
|
| 1 |
EC50 = 0.6 nM
|
|
|
|
CP0576338
|
(E)-3-[4-[(E)-2-(2-chloro-4-methoxyphenyl)-2-cyclobutyl-1-(4-morpholin-4-ylphenyl)ethenyl]phenyl]prop-2-enoic acid
Show/Hide
|
C32H32ClNO4
|
1
|
| 1 |
EC50 = 0.6 nM
|
|
|
|
CP0960903
|
(1R,3R)-1-(2,6-Difluoro-4-(3-(2-fluoroethoxy)azetidin-1-yl)-phenyl)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole
Show/Hide
|
C27H31F4N3O
|
1
|
| 1 |
EC50 = 0.61 nM
|
|
|
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CP0966891
|
3'-Fluoro-4'-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)-5'-methoxy-[1,1'-biphenyl]-4-carboxylic Acid
Show/Hide
|
C30H30F2N2O3
|
1
|
| 1 |
EC50 = 0.61 nM
|
|
|
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CP0967901
|
3',5'-Difluoro-4'-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)-[1,1'-biphenyl]-4-carboxamide
Show/Hide
|
C29H28F3N3O
|
1
|
| 1 |
EC50 = 0.66 nM
|
|
|
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CP0071951
|
(E)-3-[4-[(E)-2-(2-chloro-4-fluorophenyl)-1-(1H-indazol-5-yl)but-1-enyl]phenyl]prop-2-enoic acid
Show/Hide
|
C26H20ClFN2O2
|
4
|
| 1 |
EC50 = 0.7 nM
|
|
|
| 2 |
IC50 = 0.5 nM
|
|
|
| 3 |
IC50 = 0.85 nM
|
|
|
| 4 |
IC50 = 24 nM
|
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CP0395043
|
(E)-3-[4-[(E)-2-(2-chlorophenyl)-1-(1H-indazol-5-yl)but-1-enyl]phenyl]prop-2-enoic acid
Show/Hide
|
C26H21ClN2O2
|
1
|
| 1 |
EC50 = 0.7 nM
|
|
|
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CP0402180
|
6-(2- chlorophenyl)- 5-[4- [(3S)-1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2-ol
Show/Hide
|
C30H31ClFNO2
|
1
|
| 1 |
EC50 = 0.7 nM
|
|
|
|
CP0445891
|
US9714221, Example 11
Show/Hide
|
C30H32FNO3
|
1
|
| 1 |
EC50 = 0.7 nM
|
|
|
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CP0481786
|
5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-6-[4- (trifluoro- methoxy)- phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2- carboxylic acid
Show/Hide
|
C32H31F4NO4
|
1
|
| 1 |
EC50 = 0.7 nM
|
|
|
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CP0534711
|
(E)-3-[4-[(E)-1-(1,3-benzothiazol-5-yl)-2-(2-chloro-4-fluorophenyl)-2-cyclobutylethenyl]phenyl]prop-2-enoic acid
Show/Hide
|
C28H21ClFNO2S
|
1
|
| 1 |
EC50 = 0.7 nM
|
|
|
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CP0576336
|
(E)-3-[4-[(E)-2-(2-chloro-4-cyanophenyl)-2-cyclobutyl-1-[4-(1H-pyrazol-4-yl)phenyl]ethenyl]phenyl]prop-2-enoic acid
Show/Hide
|
C31H24ClN3O2
|
1
|
| 1 |
EC50 = 0.7 nM
|
|
|
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CP0969666
|
3',5'-Difluoro-4'-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)-[1,1'-biphenyl]-3-carboxylic Acid
Show/Hide
|
C29H27F3N2O2
|
1
|
| 1 |
EC50 = 0.7 nM
|
|
|
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CP0570341
|
2-[4-chloro-2-(1,1-difluoroethyl)phenyl]-3-[4-[(3R)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenoxy]-6H-thieno[2,3-e]indazole
Show/Hide
|
C30H27ClF3N3O2S
|
1
|
| 1 |
EC50 = 0.7 nM
|
|
|
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CP0488253
|
(E)-3-[4-[(E)-1-(1H-indazol-5-yl)-2-(2-methylphenyl)but-1-enyl]phenyl]prop-2-enoic acid
Show/Hide
|
C27H24N2O2
|
1
|
| 1 |
EC50 = 0.8 nM
|
|
|
|
CP0477377
|
(E)-3-[4-[(E)-1-(1,3-benzothiazol-5-yl)-2-(2-chloro-4-cyanophenyl)-2-cyclobutylethenyl]phenyl]prop-2-enoic acid
Show/Hide
|
C29H21ClN2O2S
|
1
|
| 1 |
EC50 = 0.8 nM
|
|
|
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CP0483024
|
(E)-3-[4-[(E)-2-(2-chloro-4-methoxyphenyl)-2-cyclobutyl-1-[4-(1,3-thiazol-5-yl)phenyl]ethenyl]phenyl]prop-2-enoic acid
Show/Hide
|
C31H26ClNO3S
|
1
|
| 1 |
EC50 = 0.8 nM
|
|
|
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CP0558009
|
(E)-3-[4-[(E)-2-(2-chloro-4-fluorophenyl)-2-cyclobutyl-1-[4-(1,3-thiazol-5-yl)phenyl]ethenyl]phenyl]prop-2-enoic acid
Show/Hide
|
C30H23ClFNO2S
|
1
|
| 1 |
EC50 = 0.8 nM
|
|
|
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CP0967352
|
3'-Chloro-5'-fluoro-4'-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)-[1,1'-biphenyl]-4-carboxylic Acid
Show/Hide
|
C29H27ClF2N2O2
|
1
|
| 1 |
EC50 = 0.85 nM
|
|
|
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CP0969895
|
(E)-3-(3,5-Difluoro-4-((1R,3S)-2-(2-fluoro-2-methylpropyl)-3-(fluoromethyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenyl)-acrylic Acid
Show/Hide
|
C25H24F4N2O2
|
1
|
| 1 |
EC50 = 0.86 nM
|
|
|
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CP0443440
|
(E)-3-[4-[(E)-2-(2-chloro-4-cyanophenyl)-1-(1H-indazol-5-yl)but-1-enyl]phenyl]prop-2-enoic acid
Show/Hide
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C27H20ClN3O2
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1
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| 1 |
EC50 = 0.9 nM
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CP0479478
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6-(2,4- dichloro- phenyl)-5-[4- [(3S)-1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2-ol
Show/Hide
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C30H30Cl2FNO2
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1
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| 1 |
EC50 = 0.9 nM
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CP0545266
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2-[2-(1,1-difluoroethyl)-4-fluorophenyl]-3-[4-[2-[3-(fluoromethyl)azetidin-1-yl]ethoxy]phenoxy]-6H-thieno[2,3-e]indazole
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C29H25F4N3O2S
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1
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| 1 |
EC50 = 0.9 nM
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CP0960881
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2-(3,5-Difluoro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenyl)-2-azaspiro-[3.3]heptane-6-carboxylic Acid
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C29H32F3N3O2
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1
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| 1 |
EC50 = 0.98 nM
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CP0491361
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(E)-3-[4-[(E)-2-(4-cyano-2-methylphenyl)-1-(1H-indazol-5-yl)but-1-enyl]phenyl]prop-2-enoic acid
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C28H23N3O2
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1
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| 1 |
EC50 = 1 nM
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CP0402179
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6-(2- chloro- phenyl)-5-[4- [(3S)-1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-8,9- dihydro- 7H- benzo[7]- annulene-2- carboxylic acid
Show/Hide
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C31H31ClFNO3
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1
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| 1 |
EC50 = 1 nM
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CP0528946
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8-[4-[(3S)-1-ethylpyrrolidin-3-yl]oxyphenyl]-7-(4-hydroxyphenyl)-5,6-dihydronaphthalen-2-ol
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C28H29NO3
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1
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| 1 |
EC50 = 1 nM
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CP0576339
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(E)-3-[4-[(E)-1-(1,3-benzothiazol-5-yl)-2-[2-chloro-4-(trifluoromethyl)phenyl]-2-cyclobutylethenyl]phenyl]prop-2-enoic acid
Show/Hide
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C29H21ClF3NO2S
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1
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| 1 |
EC50 = 1 nM
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CP0960901
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(E)-3-(5-Fluoro-6-((1S,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)pyridin-3-yl)acrylic Acid
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C24H25F2N3O2
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1
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| 1 |
EC50 = 1 nM
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CP0543545
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(E)-3-[4-[[2-[3-(1,1-difluoroethyl)-4-fluorophenyl]-6-hydroxy-1-benzothiophen-3-yl]oxy]phenyl]prop-2-enoic acid
Show/Hide
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C25H17F3O4S
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1
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| 1 |
EC50 = 1 nM
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CP0550234
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2-[4-chloro-2-(1,1-difluoroethyl)phenyl]-3-[4-[(3R)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenoxy]-1-benzothiophene-6-carboxylic acid
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C30H27ClF3NO4S
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1
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| 1 |
EC50 = 1 nM
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CP0570108
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(3R)-N-[4-[[2-[4-chloro-2-(1,1-difluoroethyl)phenyl]-6H-thieno[2,3-e]indazol-3-yl]oxy]phenyl]-1-(3-fluoropropyl)pyrrolidin-3-amine
Show/Hide
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C30H28ClF3N4OS
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1
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| 1 |
EC50 = 1 nM
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CP0967900
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5-((3,5-Difluoro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenyl)amino)-thiazole-2-carboxylic Acid
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C26H25F3N4O2S
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1
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| 1 |
EC50 = 1.08 nM
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CP0436079
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(E)-3-[4-[(E)-2-(4-chloro-2-cyanophenyl)-2-cyclobutyl-1-[4-(1H-pyrazol-4-yl)phenyl]ethenyl]phenyl]prop-2-enoic acid
Show/Hide
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C31H24ClN3O2
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1
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| 1 |
EC50 = 1.1 nM
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CP0532453
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(E)-3-[4-[(E)-1-(1,3-benzothiazol-5-yl)-2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-2-cyclobutylethenyl]phenyl]prop-2-enoic acid
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C28H20ClF3N2O2S
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1
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| 1 |
EC50 = 1.1 nM
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CP0534522
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(E)-3-[4-[(E)-2-(2-chloro-4-fluorophenyl)-2-cyclobutyl-1-[4-(1H-pyrazol-4-yl)phenyl]ethenyl]phenyl]prop-2-enoic acid
Show/Hide
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C30H24ClFN2O2
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1
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| 1 |
EC50 = 1.1 nM
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CP0545000
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2-[4-chloro-2-(1,1-difluoroethyl)phenyl]-3-[4-[1-(3-fluoropropyl)azetidin-3-yl]oxyphenoxy]-6H-thieno[2,3-e]indazole
Show/Hide
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C29H25ClF3N3O2S
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1
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| 1 |
EC50 = 1.1 nM
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CP0545265
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N-[4-[[2-[2-(1,1-difluoroethyl)-4-fluorophenyl]-6H-thieno[2,3-e]indazol-3-yl]oxy]-2-methoxyphenyl]-1-(3-fluoropropyl)azetidin-3-amine
Show/Hide
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C30H28F4N4O2S
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1
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| 1 |
EC50 = 1.1 nM
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CP0546743
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N-[4-[[2-[4-chloro-2-(1,1-difluoroethyl)phenyl]-6H-thieno[2,3-e]indazol-3-yl]oxy]phenyl]-1-(3-fluoropropyl)azetidin-3-amine
Show/Hide
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C29H26ClF3N4OS
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1
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| 1 |
EC50 = 1.2 nM
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CP0578750
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[2-[2-(1,1-difluoroethyl)-4-fluorophenyl]-3-[4-[2-[3-(fluoromethyl)azetidin-1-yl]ethoxy]phenoxy]-1-benzothiophen-6-yl]boronic acid
Show/Hide
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C28H26BF4NO4S
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1
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| 1 |
EC50 = 1.2 nM
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CP0969556
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(E)-3-(3,5-Difluoro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenyl)-N-hydroxyacrylamide
Show/Hide
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C25H26F3N3O2
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1
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| 1 |
EC50 = 1.28 nM
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CP0543544
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N-[4-[[2-[2-(1,1-difluoroethyl)-4-fluorophenyl]-6H-thieno[2,3-e]indazol-3-yl]oxy]-2-fluorophenyl]-1-(3-fluoropropyl)azetidin-3-amine
Show/Hide
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C29H25F5N4OS
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1
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| 1 |
EC50 = 1.3 nM
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CP0568297
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2-[2-(1,1-difluoroethyl)-4-fluorophenyl]-3-[3-fluoro-4-[1-(3-fluoropropyl)azetidin-3-yl]oxyphenoxy]-6H-thieno[2,3-e]indazole
Show/Hide
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C29H24F5N3O2S
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1
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| 1 |
EC50 = 1.3 nM
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CP0573007
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N-[4-[[2-[4-fluoro-2-(2-fluoropropan-2-yl)phenyl]-6H-thieno[2,3-e]indazol-3-yl]oxy]-2-methoxyphenyl]-1-(3-fluoropropyl)azetidin-3-amine
Show/Hide
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C31H31F3N4O2S
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1
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| 1 |
EC50 = 1.3 nM
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CP0483025
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(E)-3-[4-[(E)-2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-2-cyclobutyl-1-[4-(1,3-thiazol-5-yl)phenyl]ethenyl]phenyl]prop-2-enoic acid
Show/Hide
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C30H22ClF3N2O2S
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1
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| 1 |
EC50 = 1.4 nM
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CP0569178
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2-[4-fluoro-2-(2-fluoropropan-2-yl)phenyl]-3-[4-[1-(3-fluoropropyl)azetidin-3-yl]oxy-3-methoxyphenoxy]-6H-thieno[2,3-e]indazole
Show/Hide
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C31H30F3N3O3S
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1
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| 1 |
EC50 = 1.4 nM
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CP0576564
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N-[4-[[2-[4-fluoro-2-(2-fluoropropan-2-yl)phenyl]-6H-thieno[2,3-e]indazol-3-yl]oxy]phenyl]-1-(3-fluoropropyl)azetidin-3-amine
Show/Hide
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C30H29F3N4OS
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1
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| 1 |
EC50 = 1.4 nM
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CP0967903
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1-(3,5-Difluoro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenyl)pyrrolidine-3-carboxylic Acid
Show/Hide
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C27H30F3N3O2
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1
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| 1 |
EC50 = 1.47 nM
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CP0906550
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5-[4-[(3S)-1-(3-Fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-6-(1H-indazol-5-yl)-8,9-dihydro-7H-benzo[7]annulen-2-ol
Show/Hide
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C31H32FN3O2
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1
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| 1 |
EC50 = 1.5 nM
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CP0477375
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(E)-3-[4-[(E)-2-(2-chloro-4-fluorophenyl)-2-cyclobutyl-1-imidazo[1,2-a]pyridin-6-ylethenyl]phenyl]prop-2-enoic acid
Show/Hide
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C28H22ClFN2O2
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1
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| 1 |
EC50 = 1.5 nM
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CP0534713
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(E)-3-[4-[(E)-2-(2-chloro-4-methoxyphenyl)-2-cyclobutyl-1-[4-(1H-pyrazol-4-yl)phenyl]ethenyl]phenyl]prop-2-enoic acid
Show/Hide
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C31H27ClN2O3
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1
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| 1 |
EC50 = 1.5 nM
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CP0558010
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(E)-3-[4-[(E)-2-[2-chloro-4-(trifluoromethyl)phenyl]-2-cyclobutyl-1-imidazo[1,2-a]pyridin-6-ylethenyl]phenyl]prop-2-enoic acid
Show/Hide
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C29H22ClF3N2O2
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1
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| 1 |
EC50 = 1.5 nM
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CP0968874
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4-(3,5-Difluoro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenyl)morpholine
Show/Hide
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C26H30F3N3O
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1
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| 1 |
EC50 = 1.51 nM
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CP0967350
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(E)-3-(3,5-Difluoro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenyl)-acrylamide
Show/Hide
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C25H26F3N3O
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1
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| 1 |
EC50 = 1.56 nM
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CP0477376
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(E)-3-[4-[(E)-2-(2-chloro-4-fluorophenyl)-2-cyclobutyl-1-(4-morpholin-4-ylphenyl)ethenyl]phenyl]prop-2-enoic acid
Show/Hide
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C31H29ClFNO3
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1
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| 1 |
EC50 = 1.6 nM
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CP0959161
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3',5'-Dichloro-4'-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)-[1,1'-biphenyl]-4-carboxylic Acid
Show/Hide
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C29H27Cl2FN2O2
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1
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| 1 |
EC50 = 1.61 nM
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CP0040596
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(E)-3-[4-[(E)-1-(4-hydroxyphenyl)-2-phenylbut-1-enyl]phenyl]prop-2-enoic acid
Show/Hide
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C25H22O3
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6
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| 1 |
EC50 = 1.7 nM
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| 2 |
IC50 = 6.761 nM
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| 3 |
IC50 = 7 nM
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| 4 |
IC50 = 12 nM
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| 5 |
IC50 = 242 nM
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| 6 |
IC50 > 30000 nM
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CP0576335
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(E)-3-[4-[(E)-2-cyclobutyl-2-phenyl-1-[4-(1,3-thiazol-5-yl)phenyl]ethenyl]phenyl]prop-2-enoic acid
Show/Hide
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C30H25NO2S
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1
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| 1 |
EC50 = 1.7 nM
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CP0967746
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2-Chloro-3',5'-difluoro-4'-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)-[1,1'-biphenyl]-4-carboxylic Acid
Show/Hide
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C29H26ClF3N2O2
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1
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| 1 |
EC50 = 1.7 nM
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CP0532451
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(E)-3-[4-[(E)-2-(2-chloro-4-cyanophenyl)-2-cyclobutyl-1-[4-(1,3-thiazol-5-yl)phenyl]ethenyl]phenyl]prop-2-enoic acid
Show/Hide
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C31H23ClN2O2S
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1
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| 1 |
EC50 = 1.8 nM
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CP0569393
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3-[4-[1-(3-fluoropropyl)azetidin-3-yl]oxy-3-methoxyphenoxy]-2-[4-fluoro-2-(2,2,2-trifluoroethyl)phenyl]-6H-thieno[2,3-e]indazole
Show/Hide
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C30H26F5N3O3S
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1
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| 1 |
EC50 = 1.8 nM
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CP0436078
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(E)-3-[4-[(E)-2-(4-chloro-2-cyanophenyl)-2-cyclobutyl-1-[4-(1,3-thiazol-5-yl)phenyl]ethenyl]phenyl]prop-2-enoic acid
Show/Hide
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C31H23ClN2O2S
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1
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| 1 |
EC50 = 1.9 nM
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CP0567448
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(E)-3-[4-[(E)-2-[2-chloro-4-(trifluoromethyl)phenyl]-2-cyclobutyl-1-(4-morpholin-4-ylphenyl)ethenyl]phenyl]prop-2-enoic acid
Show/Hide
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C32H29ClF3NO3
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1
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| 1 |
EC50 = 1.9 nM
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CP0968189
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2-Chloro-3',5'-difluoro-4'-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)-6-methoxy-[1,1'-biphenyl]-4-carboxylic Acid
Show/Hide
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C30H28ClF3N2O3
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1
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| 1 |
EC50 = 1.92 nM
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CP0412839
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(E)-3-[4-[(E)-2-(3-chlorophenyl)-1-(1H-indazol-5-yl)but-1-enyl]phenyl]prop-2-enoic acid
Show/Hide
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C26H21ClN2O2
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1
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| 1 |
EC50 = 2 nM
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CP0494092
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(E)-3-[4-[(E)-2-(3-chloropyridin-4-yl)-1-(1H-indazol-5-yl)but-1-enyl]phenyl]prop-2-enoic acid
Show/Hide
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C25H20ClN3O2
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1
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| 1 |
EC50 = 2 nM
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CP0479476
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US9714221, Example 75
Show/Hide
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C31H31F4NO3
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1
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| 1 |
EC50 = 2 nM
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CP0547893
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5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-6-[4- (trifluoro- methyl- sulfanyl)- phenyl]- 8,9- dihydro- 7H- benzo[7]- annulen-2-ol
Show/Hide
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C31H31F4NO2S
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1
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| 1 |
EC50 = 2 nM
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CP0547894
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7-(4-hydroxyphenyl)-8-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-5,6-dihydronaphthalen-2-ol
Show/Hide
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C28H29NO3
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1
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| 1 |
EC50 = 2 nM
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CP0568223
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2-[4-fluoro-2-(2-fluoropropan-2-yl)phenyl]-3-[3-fluoro-4-[1-(3-fluoropropyl)azetidin-3-yl]oxyphenoxy]-6H-thieno[2,3-e]indazole
Show/Hide
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C30H27F4N3O2S
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1
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| 1 |
EC50 = 2 nM
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CP0484062
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(E)-3-[4-[(E)-2-cyclobutyl-2-phenyl-1-[4-(1H-pyrazol-4-yl)phenyl]ethenyl]phenyl]prop-2-enoic acid
Show/Hide
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C30H26N2O2
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1
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| 1 |
EC50 = 2.1 nM
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CP0568767
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1-(3-fluoropropyl)-N-[4-[[2-[4-fluoro-2-(2,2,2-trifluoroethyl)phenyl]-6H-thieno[2,3-e]indazol-3-yl]oxy]-2-methoxyphenyl]azetidin-3-amine
Show/Hide
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C30H27F5N4O2S
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1
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| 1 |
EC50 = 2.2 nM
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CP0569727
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N-[4-[[2-[2-(1,1-difluoroethyl)-4,5-difluorophenyl]-6H-thieno[2,3-e]indazol-3-yl]oxy]phenyl]-1-(3-fluoropropyl)azetidin-3-amine
Show/Hide
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C29H25F5N4OS
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1
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| 1 |
EC50 = 2.2 nM
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CP0571259
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1-(3-fluoropropyl)-N-[4-[[2-[4-fluoro-2-(2,2,2-trifluoroethyl)phenyl]-6H-thieno[2,3-e]indazol-3-yl]oxy]phenyl]azetidin-3-amine
Show/Hide
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C29H25F5N4OS
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1
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| 1 |
EC50 = 2.2 nM
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CP0576664
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[2-[2-(1,1-difluoroethyl)-4-fluorophenyl]-3-[4-[2-[(3R)-3-(fluoromethyl)pyrrolidin-1-yl]ethoxy]phenoxy]-1-benzothiophen-6-yl]boronic acid
Show/Hide
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C29H28BF4NO4S
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1
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| 1 |
EC50 = 2.2 nM
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CP0545264
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3-[4-[1-(3-fluoropropyl)azetidin-3-yl]oxyphenoxy]-2-[4-fluoro-2-(1,1,1-trifluoropropan-2-yl)phenyl]-6H-thieno[2,3-e]indazole
Show/Hide
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C30H26F5N3O2S
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1
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| 1 |
EC50 = 2.5 nM
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CP0967745
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(E)-3-(3,5-Dichloro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenyl)-acrylic Acid
Show/Hide
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C25H25Cl2FN2O2
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1
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| 1 |
EC50 = 2.51 nM
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CP0881991
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(E)-3-(4-((E)-1-(1H-Indazol-5-yl)-2-phenylbut-1-en-1-yl)phenyl)-acrylic Acid
Show/Hide
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C26H22N2O2
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2
|
| 1 |
EC50 = 2.6 nM
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| 2 |
EC50 = 3 nM
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CP0546742
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N-[4-[[2-[2-(1,1-difluoroethyl)-4,5-difluorophenyl]-6H-thieno[2,3-e]indazol-3-yl]oxy]-2-methoxyphenyl]-1-(3-fluoropropyl)azetidin-3-amine
Show/Hide
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C30H27F5N4O2S
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1
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| 1 |
EC50 = 2.6 nM
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CP0580059
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2-[4-chloro-2-(1,1-difluoroethyl)phenyl]-3-[4-[2-[3-(fluoromethyl)azetidin-1-yl]ethoxy]phenoxy]-1-benzothiophene-6-carboxylic acid
Show/Hide
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C29H25ClF3NO4S
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1
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| 1 |
EC50 = 2.6 nM
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CP0440958
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(E)-3-[4-[(E)-2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-2-cyclobutyl-1-[4-(1H-pyrazol-4-yl)phenyl]ethenyl]phenyl]prop-2-enoic acid
Show/Hide
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C30H23ClF3N3O2
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1
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| 1 |
EC50 = 2.8 nM
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CP0543104
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(E)-3-[4-[(E)-1-(1H-indol-5-yl)-2-phenylbut-1-enyl]phenyl]prop-2-enoic acid
Show/Hide
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C27H23NO2
|
1
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| 1 |
EC50 = 3 nM
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CP0543108
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(E)-3-[4-[(E)-2-(2-cyanophenyl)-1-(1H-indazol-5-yl)but-1-enyl]phenyl]prop-2-enoic acid
Show/Hide
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C27H21N3O2
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1
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| 1 |
EC50 = 3 nM
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CP0466434
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6-(2- Chloro-3- fluoro- phenyl)-5- {4-[(S)-1- (3-fluoro- propyl)- pyrrolidin-3- yloxy]- phenyl}-8,9- dihydro- 7H- benzocyclo- heptene-2- carboxylic acid
Show/Hide
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C31H30ClF2NO3
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1
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| 1 |
EC50 = 3 nM
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CP0551915
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2-[2-(1,1-difluoroethyl)-4,5-difluorophenyl]-3-[4-[1-(3-fluoropropyl)azetidin-3-yl]oxy-3-methoxyphenoxy]-6H-thieno[2,3-e]indazole
Show/Hide
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C30H26F5N3O3S
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1
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| 1 |
EC50 = 3 nM
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CP0967898
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(E)-3-(6-((1S,3R)-2-(2-Fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido [3,4-b]indol-1-yl)pyridin-3-yl)acrylic Acid
Show/Hide
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C24H26FN3O2
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1
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| 1 |
EC50 = 3.23 nM
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CP0571248
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2-[2-(1,1-difluoroethyl)-4,5-difluorophenyl]-3-[4-[1-(3-fluoropropyl)azetidin-3-yl]oxyphenoxy]-6H-thieno[2,3-e]indazole
Show/Hide
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C29H24F5N3O2S
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1
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| 1 |
EC50 = 3.4 nM
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CP0960906
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(E)-3-(2,6-Difluoro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenyl)-acrylic Acid
Show/Hide
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C25H25F3N2O2
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1
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| 1 |
EC50 = 3.48 nM
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CP0571814
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3-[3-fluoro-4-[1-(3-fluoropropyl)azetidin-3-yl]oxyphenoxy]-2-[4-fluoro-2-(2,2,2-trifluoroethyl)phenyl]-6H-thieno[2,3-e]indazole
Show/Hide
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C29H23F6N3O2S
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1
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| 1 |
EC50 = 3.6 nM
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CP0545402
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2-[2-(1,1-difluoroethyl)-4,5-difluorophenyl]-3-[3-fluoro-4-[1-(3-fluoropropyl)azetidin-3-yl]oxyphenoxy]-6H-thieno[2,3-e]indazole
Show/Hide
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C29H23F6N3O2S
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1
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| 1 |
EC50 = 3.9 nM
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CP0569316
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2-[4-chloro-2-(1,1-difluoroethyl)phenyl]-3-[4-[1-(3-fluoropropyl)azetidin-3-yl]oxyphenoxy]-1-benzothiophene-6-carboxylic acid
Show/Hide
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C29H25ClF3NO4S
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1
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| 1 |
EC50 = 3.9 nM
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CP0380692
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(E)-3-[4-[(E)-1-(1H-indazol-5-yl)-2-(2-methoxyphenyl)but-1-enyl]phenyl]prop-2-enoic acid
Show/Hide
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C27H24N2O3
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1
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| 1 |
EC50 = 4 nM
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CP0443439
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(E)-3-[4-[(Z)-1-(1H-indazol-5-yl)-2-phenylbut-1-enyl]-3-methoxyphenyl]prop-2-enoic acid
Show/Hide
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C27H24N2O3
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1
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| 1 |
EC50 = 4 nM
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CP0534684
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(E)-3-[4-[(E)-2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-2-cyclobutyl-1-(4-morpholin-4-ylphenyl)ethenyl]phenyl]prop-2-enoic acid
Show/Hide
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C31H28ClF3N2O3
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1
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| 1 |
EC50 = 4.1 nM
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CP0532452
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(E)-3-[4-[(E)-2-(2-chloro-4-cyanophenyl)-2-cyclobutyl-1-(4-morpholin-4-ylphenyl)ethenyl]phenyl]prop-2-enoic acid
Show/Hide
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C32H29ClN2O3
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1
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| 1 |
EC50 = 4.2 nM
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CP0477378
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(E)-3-[4-[(E)-2-(4-chloro-2-cyanophenyl)-2-cyclobutyl-1-imidazo[1,2-a]pyridin-6-ylethenyl]phenyl]prop-2-enoic acid
Show/Hide
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C29H22ClN3O2
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1
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| 1 |
EC50 = 4.3 nM
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CP0967410
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(E)-3-(3,5-Difluoro-4-((1R,3R)-3-methyl-2-((1-(trifluoromethyl)-cyclopropyl)methyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenyl)acrylic Acid
Show/Hide
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C26H23F5N2O2
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1
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| 1 |
EC50 = 4.48 nM
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CP0967902
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(E)-3-(4-((1R,3R)-2-(2-Fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)-3,5-dimethoxyphenyl)-acrylic Acid
Show/Hide
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C27H31FN2O4
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1
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| 1 |
EC50 = 4.67 nM
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CP0477164
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(E)-3-[4-[(E)-2-[2-chloro-4-(trifluoromethyl)phenyl]-2-cyclobutyl-1-[4-(1H-pyrazol-4-yl)phenyl]ethenyl]phenyl]prop-2-enoic acid
Show/Hide
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C31H24ClF3N2O2
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1
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| 1 |
EC50 = 4.8 nM
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CP0055255
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[(7S,8R,9S,13S,14S,17S)-7-(4-bromophenyl)sulfanyl-3-hydroxy-13-methyl-6-oxo-8,9,11,12,14,15,16,17-octahydro-7H-cyclopenta[a]phenanthren-17-yl] acetate
Show/Hide
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C26H27BrO4S
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1
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| 1 |
EC50 = 5 nM
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CP0477163
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(E)-3-[4-[(E)-2-(4-chloro-2-cyanophenyl)-2-cyclobutyl-1-(4-morpholin-4-ylphenyl)ethenyl]phenyl]prop-2-enoic acid
Show/Hide
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C32H29ClN2O3
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1
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| 1 |
EC50 = 5 nM
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CP0964121
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(E)-3-(4-((1R,3R)-2-Butyl-3-methyl-2,3,4,9-tetrahydro-1H-pyrido-[3,4-b]indol-1-yl)-3,5-difluorophenyl)acrylic Acid
Show/Hide
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C25H26F2N2O2
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1
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| 1 |
EC50 = 5.39 nM
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CP0484060
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(E)-3-[4-[(E)-1-(1,3-benzothiazol-5-yl)-2-cyclobutyl-2-phenylethenyl]phenyl]prop-2-enoic acid
Show/Hide
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C28H23NO2S
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1
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| 1 |
EC50 = 5.9 nM
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CP0499160
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(E)-3-[4-[(E)-1-(1H-indazol-5-yl)-2-phenylbut-1-enyl]-2-methylphenyl]prop-2-enoic acid
Show/Hide
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C27H24N2O2
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1
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| 1 |
EC50 = 6 nM
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CP0543107
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(E)-3-[4-[(E)-1-(1H-indazol-4-yl)-2-phenylbut-1-enyl]phenyl]prop-2-enoic acid
Show/Hide
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C26H22N2O2
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1
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| 1 |
EC50 = 6 nM
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CP0964123
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(1R,3R)-1-(4-(4,4-Difluoropiperidin-1-yl)-2,6-difluorophenyl)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido-[3,4-b]indole
Show/Hide
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C27H30F5N3
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1
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| 1 |
EC50 = 6.27 nM
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CP0570403
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1-(3-fluoropropyl)-N-[4-[[2-[4-fluoro-2-(1,1,1,2-tetrafluoropropan-2-yl)phenyl]-6H-thieno[2,3-e]indazol-3-yl]oxy]phenyl]azetidin-3-amine
Show/Hide
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C30H26F6N4OS
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1
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| 1 |
EC50 = 6.6 nM
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CP0967747
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1-((3,5-Difluoro-4-((3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenyl)amino)-cyclopropane-1-carboxylic Acid
Show/Hide
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C26H28F3N3O2
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1
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| 1 |
EC50 = 6.85 nM
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CP0200751
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(7S,8R,9S,13S,14S,17S)-7-(4-bromophenyl)sulfanyl-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,6,17-triol
Show/Hide
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C24H27BrO3S
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1
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| 1 |
EC50 = 7 nM
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CP0477156
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(E)-3-[4-[(E)-2-phenyl-1-[4-(1,3-thiazol-5-yl)phenyl]but-1-enyl]phenyl]prop-2-enoic acid
Show/Hide
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C28H23NO2S
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1
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| 1 |
EC50 = 7.4 nM
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CP0968223
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1-(3,5-Difluoro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenyl)piperidine-4-carboxylic Acid
Show/Hide
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C28H32F3N3O2
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1
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| 1 |
EC50 = 7.8 nM
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CP0488252
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(E)-3-[4-[(E)-1-(1H-indazol-5-yl)-2-(3-methylpyridin-4-yl)but-1-enyl]phenyl]prop-2-enoic acid
Show/Hide
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C26H23N3O2
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1
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| 1 |
EC50 = 8 nM
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CP0466437
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6-(4- chloro- phenyl)-5-[4- [(3S)-1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-8,9- dihydro- 7H- benzo[7]- annulene-2- carboxylic acid
Show/Hide
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C31H31ClFNO3
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1
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| 1 |
EC50 = 8 nM
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CP0554863
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5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-6-[4- (trifluoro- methyl- sulfanyl)- phenyl]-8,9- dihydro- 7H- benzo[7]- annulene-2- carboxylic acid
Show/Hide
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C32H31F4NO3S
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1
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| 1 |
EC50 = 8 nM
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CP0006292
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(1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-2,4,6-triene-5,14-diol
Show/Hide
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C18H24O2
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2
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| 1 |
EC50 = 10 nM
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| 2 |
IC50 = 0.2 nM
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CP0510936
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(E)-3-[4-[(E)-2-(4-chlorophenyl)-1-(1H-indazol-5-yl)but-1-enyl]phenyl]prop-2-enoic acid
Show/Hide
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C26H21ClN2O2
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1
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| 1 |
EC50 = 10 nM
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CP0395041
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(E)-3-[4-[(Z)-1-(1H-indazol-5-yl)-2-phenylbut-1-enyl]-2-methoxyphenyl]prop-2-enoic acid
Show/Hide
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C27H24N2O3
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1
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| 1 |
EC50 = 11 nM
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CP0533859
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(E)-3-[4-[(E)-2-phenyl-1-[4-(1H-pyrazol-4-yl)phenyl]but-1-enyl]phenyl]prop-2-enoic acid
Show/Hide
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C28H24N2O2
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1
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| 1 |
EC50 = 12 nM
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CP0081458
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(E)-3-[4-[[(7R,8R,9S,13S,14S,17S)-3,17-dihydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-7-yl]sulfanyl]phenyl]prop-2-enoic acid
Show/Hide
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C27H30O4S
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1
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| 1 |
EC50 = 13 nM
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CP0579352
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2-[4-chloro-2-(1,1-difluoroethyl)phenyl]-3-[4-[[1-(3-fluoropropyl)azetidin-3-yl]amino]phenoxy]-1-benzothiophene-6-carboxylic acid
Show/Hide
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C29H26ClF3N2O3S
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1
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| 1 |
EC50 = 13.1 nM
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CP0950626
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(E)-3-(4-((E)-1-(1H-Benzo[d][1,2,3]triazol-5-yl)-2-phenylbut-1-en-1-yl)phenyl)acrylic Acid
Show/Hide
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C25H21N3O2
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1
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| 1 |
EC50 = 14 nM
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CP0574707
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(E)-3-[3,5-difluoro-4-[(1R,3R)-2-(2-fluoro-2-methylpropyl)-3,9-dimethyl-3,4,4a,9a-tetrahydro-1H-pyrido[3,4-b]indol-1-yl]phenyl]prop-2-enoic acid
Show/Hide
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C26H29F3N2O2
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1
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| 1 |
EC50 = 14.8 nM
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CP0566571
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(E)-3-[4-[(Z)-1-(1H-indazol-5-yl)-2-phenylbut-1-enyl]-3-methylphenyl]prop-2-enoic acid
Show/Hide
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C27H24N2O2
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1
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| 1 |
EC50 = 15 nM
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CP0534717
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(E)-3-[4-[(E)-1-[4-(1-methylpyrazol-4-yl)phenyl]-2-phenylbut-1-enyl]phenyl]prop-2-enoic acid
Show/Hide
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C29H26N2O2
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1
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| 1 |
EC50 = 15 nM
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CP0567393
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(E)-3-[4-[(E)-1-[4-(1,3-oxazol-5-yl)phenyl]-2-phenylbut-1-enyl]phenyl]prop-2-enoic acid
Show/Hide
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C28H23NO3
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1
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| 1 |
EC50 = 17 nM
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CP0532450
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(E)-3-[4-[(E)-2-(2-chloro-4-cyanophenyl)-2-cyclobutyl-1-imidazo[1,2-a]pyridin-6-ylethenyl]phenyl]prop-2-enoic acid
Show/Hide
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C29H22ClN3O2
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1
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| 1 |
EC50 = 19 nM
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CP0534716
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(E)-3-[4-[(E)-1-(1,3-benzothiazol-5-yl)-2-phenylbut-1-enyl]phenyl]prop-2-enoic acid
Show/Hide
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C26H21NO2S
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1
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| 1 |
EC50 = 22 nM
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CP0412838
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(E)-3-[4-[(E)-1-(2-oxo-3H-1,3-benzoxazol-6-yl)-2-phenylbut-1-enyl]phenyl]prop-2-enoic acid
Show/Hide
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C26H21NO4
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1
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| 1 |
EC50 = 23 nM
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CP0517672
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(E)-3-[4-[(E)-2-(2-chloro-4-fluorophenyl)-1-(1-methylindazol-5-yl)but-1-enyl]phenyl]prop-2-enoic acid
Show/Hide
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C27H22ClFN2O2
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1
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| 1 |
EC50 = 27 nM
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CP0244419
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N-butyl-11-[[(7S,8R,9S,13S,14S,17S)-3,17-dihydroxy-13-methyl-6-oxo-8,9,11,12,14,15,16,17-octahydro-7H-cyclopenta[a]phenanthren-7-yl]sulfanyl]-N-methylundecanamide
Show/Hide
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C34H53NO4S
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2
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| 1 |
EC50 = 28 nM
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| 2 |
IC50 = 519 nM
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CP0542677
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(E)-3-[4-[(E)-2-(3-cyanophenyl)-1-(1H-indazol-5-yl)but-1-enyl]phenyl]prop-2-enoic acid
Show/Hide
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C27H21N3O2
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1
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| 1 |
EC50 = 28 nM
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CP0477158
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(E)-3-[4-[(E)-2-phenyl-1-[4-(1,2-thiazol-4-yl)phenyl]but-1-enyl]phenyl]prop-2-enoic acid
Show/Hide
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C28H23NO2S
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1
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| 1 |
EC50 = 28 nM
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CP0969812
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(E)-3-(3,5-Difluoro-4-(2'-(2-fluoro-2-methylpropyl)-1',2',4',9'-tetrahydrospiro[cyclopropane-1,3'-pyrido[3,4-b]indol]-1'-yl)-phenyl)acrylic Acid
Show/Hide
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C26H25F3N2O2
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1
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| 1 |
EC50 = 32.9 nM
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CP0550041
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(E)-3-[4-[(E)-2-(4-cyanophenyl)-1-(1H-indazol-5-yl)but-1-enyl]phenyl]prop-2-enoic acid
Show/Hide
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C27H21N3O2
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1
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| 1 |
EC50 = 36 nM
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CP0484059
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(E)-3-[4-[(E)-2-phenyl-1-[4-(1,3-thiazol-4-yl)phenyl]but-1-enyl]phenyl]prop-2-enoic acid
Show/Hide
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C28H23NO2S
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1
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| 1 |
EC50 = 37 nM
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CP0391057
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4-(2-phenyl-1H-indol-3-yl)phenol
Show/Hide
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C20H15NO
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1
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| 1 |
EC50 = 38.5 nM
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CP0214232
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N-butyl-N-methyl-11-[[(6R,7S,8R,9S,13S,14S,17S)-3,6,17-trihydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-7-yl]sulfanyl]undecanamide
Show/Hide
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C34H55NO4S
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2
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| 1 |
EC50 = 40 nM
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| 2 |
IC50 = 316 nM
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CP0380695
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(E)-3-[4-[(E)-1-(1H-indazol-5-yl)-2-(2-methylsulfonylphenyl)but-1-enyl]phenyl]prop-2-enoic acid
Show/Hide
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C27H24N2O4S
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1
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| 1 |
EC50 = 49 nM
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CP0477159
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(E)-3-[4-[(E)-1-(4-morpholin-4-ylphenyl)-2-phenylbut-1-enyl]phenyl]prop-2-enoic acid
Show/Hide
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C29H29NO3
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1
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| 1 |
EC50 = 50 nM
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CP0477373
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(E)-3-[4-[(E)-1-naphthalen-2-yl-2-phenylbut-1-enyl]phenyl]prop-2-enoic acid
Show/Hide
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C29H24O2
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1
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| 1 |
EC50 = 57 nM
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CP0424170
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(E)-3-[4-[(E)-1-imidazo[1,2-a]pyridin-6-yl-2-phenylbut-1-enyl]phenyl]prop-2-enoic acid
Show/Hide
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C26H22N2O2
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1
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| 1 |
EC50 = 75 nM
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CP0477369
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(E)-3-[4-[(E)-2-phenyl-1-[4-(1,3-thiazol-2-yl)phenyl]but-1-enyl]phenyl]prop-2-enoic acid
Show/Hide
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C28H23NO2S
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1
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| 1 |
EC50 = 83 nM
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CP0477374
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(E)-3-[4-[(E)-1-[4-(4-methylpiperazin-1-yl)phenyl]-2-phenylbut-1-enyl]phenyl]prop-2-enoic acid
Show/Hide
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C30H32N2O2
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1
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| 1 |
EC50 = 90 nM
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CP0533858
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(E)-3-[4-[(E)-2-phenyl-1-[4-(1H-pyrazol-5-yl)phenyl]but-1-enyl]phenyl]prop-2-enoic acid
Show/Hide
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C28H24N2O2
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1
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| 1 |
EC50 = 99 nM
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CP0510937
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(E)-3-[4-[(E)-1-(2-oxo-3H-1,3-benzothiazol-6-yl)-2-phenylbut-1-enyl]phenyl]prop-2-enoic acid
Show/Hide
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C26H21NO3S
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1
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| 1 |
EC50 = 101 nM
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CP0385507
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(E)-3-[4-[(E)-1-(1H-indazol-5-yl)-2-(4-methylpyridin-3-yl)but-1-enyl]phenyl]prop-2-enoic acid
Show/Hide
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C26H23N3O2
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1
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| 1 |
EC50 = 110 nM
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CP0861049
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(E)-3-(5-((Z)-1-(1H-indazol-5-yl)-2-phenylbut-1-en-1-yl)pyridin-2-yl)acrylic acid
Show/Hide
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C25H21N3O2
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1
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| 1 |
EC50 = 110 nM
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CP0516089
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(E)-3-[4-[(Z)-2-(4-hydroxyphenyl)-1-phenylbut-1-enyl]phenyl]prop-2-enoic acid
Show/Hide
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C25H22O3
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1
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| 1 |
EC50 = 113 nM
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CP0558008
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(E)-3-[4-[(E)-1-(1-methylindazol-5-yl)-2-phenylbut-1-enyl]phenyl]prop-2-enoic acid
Show/Hide
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C27H24N2O2
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1
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| 1 |
EC50 = 140 nM
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CP0477155
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(E)-3-[4-[(E)-1-(2-methyl-1,3-benzothiazol-5-yl)-2-phenylbut-1-enyl]phenyl]prop-2-enoic acid
Show/Hide
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C27H23NO2S
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1
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| 1 |
EC50 = 150 nM
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CP0540806
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(E)-3-[4-[(E)-1-(1H-indazol-5-yl)-2-(2-methylpyridin-3-yl)but-1-enyl]phenyl]prop-2-enoic acid
Show/Hide
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C26H23N3O2
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1
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| 1 |
EC50 = 160 nM
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CP0208541
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(E)-3-[4-[[(7R,8R,9S,13S,14S,17S)-3,17-dihydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-7-yl]sulfanyl]phenyl]-N,N-dimethylprop-2-enamide
Show/Hide
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C29H35NO3S
|
1
|
| 1 |
EC50 = 173 nM
|
|
|
|
CP0519320
|
(E)-3-[4-[(E)-2-phenyl-1-(4-piperidin-1-ylphenyl)but-1-enyl]phenyl]prop-2-enoic acid
Show/Hide
|
C30H31NO2
|
1
|
| 1 |
EC50 = 190 nM
|
|
|
|
CP0534521
|
(E)-3-[4-[(E)-1-(1,2-benzothiazol-5-yl)-2-phenylbut-1-enyl]phenyl]prop-2-enoic acid
Show/Hide
|
C26H21NO2S
|
1
|
| 1 |
EC50 = 200 nM
|
|
|
|
CP0519319
|
(E)-3-[4-[(E)-1-(1,3-benzothiazol-6-yl)-2-phenylbut-1-enyl]phenyl]prop-2-enoic acid
Show/Hide
|
C26H21NO2S
|
1
|
| 1 |
EC50 = 240 nM
|
|
|
|
CP0485645
|
4-(5-phenyl-2-(trifluoromethyl)-1H-imidazol-4-yl)phenol
Show/Hide
|
C16H11F3N2O
|
1
|
| 1 |
EC50 = 243 nM
|
|
|
|
CP0534519
|
(E)-3-[4-[(E)-1-imidazo[1,5-a]pyridin-6-yl-2-phenylbut-1-enyl]phenyl]prop-2-enoic acid
Show/Hide
|
C26H22N2O2
|
1
|
| 1 |
EC50 = 260 nM
|
|
|
|
CP0477370
|
(E)-3-[4-[(E)-1-(4-imidazol-1-ylphenyl)-2-phenylbut-1-enyl]phenyl]prop-2-enoic acid
Show/Hide
|
C28H24N2O2
|
1
|
| 1 |
EC50 = 300 nM
|
|
|
|
CP0208672
|
(7R,8R,9S,13S,14S,17S)-3-methoxy-13-methyl-7-[4-(2-piperidin-1-ylethoxy)phenyl]sulfanyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-ol
Show/Hide
|
C32H43NO3S
|
1
|
| 1 |
EC50 = 336 nM
|
|
|
|
CP0477372
|
(E)-3-[4-[(E)-2-phenyl-1-(triazolo[1,5-a]pyridin-5-yl)but-1-enyl]phenyl]prop-2-enoic acid
Show/Hide
|
C25H21N3O2
|
1
|
| 1 |
EC50 = 340 nM
|
|
|
|
CP0477371
|
(E)-3-[4-[(E)-2-phenyl-1-pyrazolo[1,5-a]pyridin-5-ylbut-1-enyl]phenyl]prop-2-enoic acid
Show/Hide
|
C26H22N2O2
|
1
|
| 1 |
EC50 = 350 nM
|
|
|
|
CP0406140
|
(E)-3-[4-[(E)-1-(1H-indazol-6-yl)-2-phenylbut-1-enyl]phenyl]prop-2-enoic acid
Show/Hide
|
C26H22N2O2
|
1
|
| 1 |
EC50 = 357 nM
|
|
|
|
CP0970209
|
(E)-3-(3,5-Difluoro-4-((1R,3R)-3-methyl-2-phenyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenyl)acrylic Acid
Show/Hide
|
C27H22F2N2O2
|
1
|
| 1 |
EC50 = 365 nM
|
|
|
|
CP0160687
|
(2E)-3-{4-[(1E)-1,2-DIPHENYLBUT-1-ENYL]PHENYL}ACRYLIC ACID
Show/Hide
|
C25H22O2
|
8
|
| 1 |
EC50 = 390 nM
|
|
|
| 2 |
IC50 = 264 nM
|
|
|
| 3 |
IC50 = 654 nM
|
|
|
| 4 |
IC50 = 1288.25 nM
|
|
|
| 5 |
IC50 = 4000 nM
|
|
|
| 6 |
IC50 = 12825 nM
|
|
|
| 7 |
IC50 > 100000 nM
|
|
|
| 8 |
IC50 > 1270 nM
|
|
|
|
CP0484058
|
(E)-3-[4-[(E)-1-(1,3-benzoxazol-5-yl)-2-phenylbut-1-enyl]phenyl]prop-2-enoic acid
Show/Hide
|
C26H21NO3
|
1
|
| 1 |
EC50 = 460 nM
|
|
|
|
CP0914168
|
(E)-3-(4-((E)-1-(1H-Benzo[d]imidazol-5-yl)-2-phenylbut-1-en-1-yl)phenyl)acrylic acid
Show/Hide
|
C26H22N2O2
|
1
|
| 1 |
EC50 = 957 nM
|
|
|
|
CP0491360
|
(E)-3-[4-[(E)-1-[4-(methanesulfonamido)phenyl]-2-phenylbut-1-enyl]phenyl]prop-2-enoic acid
Show/Hide
|
C26H25NO4S
|
1
|
| 1 |
EC50 = 1050 nM
|
|
|
|
CP0406142
|
(E)-3-[4-[(Z)-1-(1H-indazol-5-yl)-2-phenylbut-1-enyl]thiophen-2-yl]prop-2-enoic acid
Show/Hide
|
C24H20N2O2S
|
1
|
| 1 |
EC50 = 1130 nM
|
|
|
|
CP0542678
|
(E)-3-[4-[(E)-1-(6-oxo-1H-pyridin-3-yl)-2-phenylbut-1-enyl]phenyl]prop-2-enoic acid
Show/Hide
|
C24H21NO3
|
1
|
| 1 |
EC50 = 6280 nM
|
|
|
|
CP0654308
|
4-[4-(2,4-Dioxothiazolidin-5-ylidenemethyl)-2-methoxyphenoxy]-3-trifluoromethylbenzonitrile
Show/Hide
|
C19H11F3N2O4S
|
2
|
| 1 |
EC50 > 15000 nM
|
|
|
| 2 |
IC50 > 15000 nM
|
|
|
|
CP0436077
|
(E)-3-[4-[(E)-1-imidazo[1,2-a]pyridin-7-yl-2-phenylbut-1-enyl]phenyl]prop-2-enoic acid
Show/Hide
|
C26H22N2O2
|
1
|
| 1 |
EC50 > 500 nM
|
|
|
|
CP0468989
|
(E)-3-[4-[(E)-2-phenyl-1-(tetrazolo[1,5-a]pyridin-6-yl)but-1-enyl]phenyl]prop-2-enoic acid
Show/Hide
|
C24H20N4O2
|
1
|
| 1 |
EC50 > 500 nM
|
|
|
|
CP0534520
|
(E)-3-[4-[(E)-2-phenyl-1-([1,2,4]triazolo[4,3-a]pyridin-6-yl)but-1-enyl]phenyl]prop-2-enoic acid
Show/Hide
|
C25H21N3O2
|
1
|
| 1 |
EC50 > 500 nM
|
|
|
|
CP0442479
|
4-(2-(1-methyl-1H-pyrrol-2-yl)-1H-benzo[d]imidazol-1-yl)phenol
Show/Hide
|
C18H15N3O
|
1
|
| 1 |
EC50 > 1000 nM
|
|
|
|
CP0960882
|
(E)-3-(3,5-Difluoro-4-((1R,3R)-2-(3-fluoro-3-methylbutyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenyl)acrylic Acid
Show/Hide
|
C26H27F3N2O2
|
1
|
| 1 |
EC50 > 1000 nM
|
|
|
|
CP0960884
|
1-(4-(3,5-Difluoro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenyl)-piperazin-1-yl)prop-2-en-1-one
Show/Hide
|
C29H33F3N4O
|
1
|
| 1 |
EC50 > 1000 nM
|
|
|
|
CP0966890
|
1-(3,5-Difluoro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenyl)-N,N-dimethylazetidin-3-amine
Show/Hide
|
C27H33F3N4
|
1
|
| 1 |
EC50 > 1000 nM
|
|
|
|
CP0967748
|
4-(3,5-Difluoro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenyl)-thiomorpholine 1,1-Dioxide
Show/Hide
|
C26H30F3N3O2S
|
1
|
| 1 |
EC50 > 1000 nM
|
|
|
|
CP0568236
|
2-[2-(1,1-difluoroethyl)-4-fluorophenyl]-3-[4-[2-[3-(fluoromethyl)azetidin-1-yl]ethoxymethyl]phenoxy]-6H-thieno[2,3-e]indazole
Show/Hide
|
C30H27F4N3O2S
|
1
|
| 1 |
EC50 > 1000 nM
|
|
|
|
CP0569726
|
2-[2-(1,1-difluoroethyl)-4-fluorophenyl]-3-[4-[2-[3-(fluoromethyl)azetidin-1-yl]ethylsulfonyl]phenoxy]-6H-thieno[2,3-e]indazole
Show/Hide
|
C29H25F4N3O3S2
|
1
|
| 1 |
EC50 > 1000 nM
|
|
|
|
CP0570342
|
2-[4-chloro-2-(1,1-difluoroethyl)phenyl]-3-[4-[[(2R)-1-(3-fluoropropyl)pyrrolidin-2-yl]methoxy]phenoxy]-6H-thieno[2,3-e]indazole
Show/Hide
|
C31H29ClF3N3O2S
|
1
|
| 1 |
EC50 > 1000 nM
|
|
|
|
CP0574630
|
3-[4-[2-(6,6-difluoro-3-azabicyclo[3.1.0]hexan-3-yl)ethoxy]phenoxy]-2-[2-(1,1-difluoroethyl)-4-fluorophenyl]-6H-thieno[2,3-e]indazole
Show/Hide
|
C30H24F5N3O2S
|
1
|
| 1 |
EC50 > 1000 nM
|
|
|
|
CP0540900
|
(2S)-4-chloro-2-[4-[2-[3-(fluoromethyl)azetidin-1-yl]ethoxy]phenyl]-3-(3-hydroxyphenyl)-2H-chromen-6-ol
Show/Hide
|
C27H25ClFNO4
|
1
|
| 1 |
IC50 = 0.01 nM
|
|
|
|
CP0155237
|
(S)-2-(4-(2-(3-(fluoromethyl)azetidin-1-yl)ethoxy)phenyl)-3-(3-hydroxyphenyl)-4-methyl-2H-chromen-6-ol
Show/Hide
|
C28H28FNO4
|
2
|
| 1 |
IC50 = 0.03 nM
|
|
|
| 2 |
IC50 = 0.1 nM
|
|
|
|
CP0426222
|
(2S)-5-chloro-2-[4-[2-[3-(fluoromethyl)azetidin-1-yl]ethoxy]phenyl]-3-(4-fluorophenyl)-4-methyl-2H-chromen-6-ol
Show/Hide
|
C28H26ClF2NO3
|
1
|
| 1 |
IC50 = 0.03 nM
|
|
|
|
CP0943752
|
N-(4-((6S,8R)-7-(2,2-Difluoropropyl)-8-methyl-6,7,8,9-tetrahydro-3H-pyrazolo[4,3-f]isoquinolin-6-yl)-3-methoxyphenyl)-1-(3-fluoropropyl)azetidin-3-amine
Show/Hide
|
C27H34F3N5O
|
1
|
| 1 |
IC50 = 0.03981 nM
|
|
|
|
CP0430259
|
19-[4-[2-[3-(fluoromethyl)azetidin-1-yl]ethoxy]phenyl]-8,18-dioxatetracyclo[9.8.0.02,7.012,17]nonadeca-1(11),2(7),3,5,12(17),13,15-heptaene-5,15-diol
Show/Hide
|
C29H28FNO5
|
1
|
| 1 |
IC50 = 0.045 nM
|
|
|
|
CP0488773
|
(2S)-2-[4-[2-[3-(fluoromethyl)azetidin-1-yl]ethoxy]phenyl]-3-(3-hydroxyphenyl)-4-methyl-2H-chromen-8-ol
Show/Hide
|
C28H28FNO4
|
1
|
| 1 |
IC50 = 0.05 nM
|
|
|
|
CP0923144
|
2-fluoro-6-((6S,8R)-1-fluoro-8-methyl-7-(2,2,2-trifluoroethyl)-6,7,8,9-tetrahydro-3H-pyrazolo[4,3-f]isoquinolin-6-yl)-N-(1-(3-fluoropropyl)azetidin-3-yl)pyridin-3-amine
Show/Hide
|
C24H26F6N6
|
1
|
| 1 |
IC50 = 0.05012 nM
|
|
|
|
CP0537836
|
19-[4-[(2S)-2-[(3R)-3-(fluoromethyl)pyrrolidin-1-yl]propoxy]phenyl]-8,18-dioxatetracyclo[9.8.0.02,7.012,17]nonadeca-1(11),2(7),3,5,12(17),13,15-heptaene-5,15-diol
Show/Hide
|
C31H32FNO5
|
1
|
| 1 |
IC50 = 0.051 nM
|
|
|
|
CP0864287
|
(1R,3R)-1-(2,6-difluoro-4-((1-(3-fluoropropyl)azetidin-3-yl)oxy)phenyl)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole
Show/Hide
|
C28H33F4N3O
|
1
|
| 1 |
IC50 = 0.053 nM
|
|
|
|
CP0483090
|
(19S)-19-[4-[2-[3-(fluoromethyl)azetidin-1-yl]ethoxy]phenyl]-8,18-dioxatetracyclo[9.8.0.02,7.012,17]nonadeca-1(11),2(7),3,5,12(17),13,15-heptaene-5,15-diol
Show/Hide
|
C29H28FNO5
|
1
|
| 1 |
IC50 = 0.055 nM
|
|
|
|
CP0530166
|
(19R)-19-[4-[2-[3-(fluoromethyl)azetidin-1-yl]ethoxy]phenyl]-8,18-dioxatetracyclo[9.8.0.02,7.012,17]nonadeca-1(11),2(7),3,5,12(17),13,15-heptaene-5,15-diol
Show/Hide
|
C29H28FNO5
|
1
|
| 1 |
IC50 = 0.059 nM
|
|
|
|
CP0910627
|
1-(3-Fluoropropyl)-N-(3-methoxy-4-((6S,8R)-8-methyl-7-(2,2,2-trifluoroethyl)-6,7,8,9-tetrahydro-3H-pyrazolo[4,3-f]isoquinolin-6-yl)phenyl)azetidin-3-amine
Show/Hide
|
C26H31F4N5O
|
1
|
| 1 |
IC50 = 0.0631 nM
|
|
|
|
CP0895121
|
(1R,3R)-1-(2,6-difluoro-4-(1-propylazetidin-3-yloxy)phenyl)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole
Show/Hide
|
C28H34F3N3O
|
1
|
| 1 |
IC50 = 0.065 nM
|
|
|
|
CP0402276
|
(2S)-3-cyclohexyl-2-[4-[2-[3-(fluoromethyl)azetidin-1-yl]ethoxy]phenyl]-4-methyl-2H-chromen-6-ol
Show/Hide
|
C28H34FNO3
|
1
|
| 1 |
IC50 = 0.07 nM
|
|
|
|
CP0528178
|
19-[4-[2-[(3R)-3-(fluoromethyl)pyrrolidin-1-yl]ethoxy]phenyl]-8,18-dioxatetracyclo[9.8.0.02,7.012,17]nonadeca-1(11),2(7),3,5,12(17),13,15-heptaene-5,15-diol
Show/Hide
|
C30H30FNO5
|
1
|
| 1 |
IC50 = 0.076 nM
|
|
|
|
CP0418825
|
(1R,3R)-1-[2,6-difluoro-4-[2-[3-(fluoromethyl)azetidin-1-yl]ethoxy]phenyl]-2-(2-fluoro-2-methylpropyl)-3-methyl-1,3,4,9-tetrahydropyrido[3,4-b]indole
Show/Hide
|
C28H33F4N3O
|
2
|
| 1 |
IC50 = 0.07943 nM
|
|
|
| 2 |
IC50 = 0.19 nM
|
|
|
|
CP0575375
|
(2S)-2-[4-[2-[3-(fluoromethyl)azetidin-1-yl]ethoxy]phenyl]-4-methyl-3-(1H-pyrazol-4-yl)-2H-chromen-6-ol
Show/Hide
|
C25H26FN3O3
|
1
|
| 1 |
IC50 = 0.08 nM
|
|
|
|
CP0870596
|
(1R,3R)-1-(2,6-difluoro-4-(1-(prop-2-ynyl)azetidin-3-yloxy)phenyl)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole
Show/Hide
|
C28H30F3N3O
|
1
|
| 1 |
IC50 = 0.083 nM
|
|
|
|
CP0901629
|
(1R,3R)-1-(4-(2-(3-(difluoromethyl)azetidin-1-yl)ethoxy)-2,6-difluorophenyl)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole
Show/Hide
|
C28H32F5N3O
|
1
|
| 1 |
IC50 = 0.09 nM
|
|
|
|
CP0939305
|
(1R,3R)-1-(2,6-difluoro-4-(2-((R)-3-(fluoromethyl)pyrrolidin-1-yl)ethoxy)phenyl)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole
Show/Hide
|
C29H35F4N3O
|
1
|
| 1 |
IC50 = 0.09 nM
|
|
|
|
CP0081673
|
US10227334, Example (S)-3-(3-Hydroxyphenyl)-4-methyl-2-(4-((S)-2-((R)-3-methylpyrrolidin-1- yl)propoxy)phenyl)-2H-chromen-6-ol
Show/Hide
|
C30H33NO4
|
1
|
| 1 |
IC50 = 0.1 nM
|
|
|
|
CP0435376
|
3-(4-hydroxyphenyl)-4-methyl-2-[4-[(2S)-2-[(3R)-3-methylpyrrolidin-1-yl]propoxy]phenyl]-2H-chromen-6-ol
Show/Hide
|
C30H33NO4
|
1
|
| 1 |
IC50 = 0.1 nM
|
|
|
|
CP0455828
|
(2S)-2-[4-[2-[3-(fluoromethyl)azetidin-1-yl]ethoxy]phenyl]-3-(4-fluorophenyl)-4-methyl-2H-chromen-6-ol
Show/Hide
|
C28H27F2NO3
|
2
|
| 1 |
IC50 = 0.1 nM
|
|
|
| 2 |
IC50 = 0.3 nM
|
|
|
|
CP0484090
|
(2S)-2-[4-[(2S)-2-[(3R)-3-(fluoromethyl)pyrrolidin-1-yl]propoxy]phenyl]-3-(3-hydroxyphenyl)-4-methyl-2H-chromen-6-ol
Show/Hide
|
C30H32FNO4
|
1
|
| 1 |
IC50 = 0.1 nM
|
|
|
|
CP0535630
|
2-[4-[2-[(3R)-3-(fluoromethyl)pyrrolidin-1-yl]ethoxy]phenyl]-3-(3-hydroxyphenyl)-4-methyl-2H-chromen-6-ol
Show/Hide
|
C29H30FNO4
|
1
|
| 1 |
IC50 = 0.1 nM
|
|
|
|
CP0535631
|
2-[4-[2-[4-(fluoromethyl)piperidin-1-yl]ethoxy]phenyl]-3-(3-hydroxyphenyl)-4-methyl-2H-chromen-6-ol
Show/Hide
|
C30H32FNO4
|
1
|
| 1 |
IC50 = 0.1 nM
|
|
|
|
CP0916888
|
N-(4-((6S,8R)-7-(2,2-Difluoroethyl)-8-methyl-6,7,8,9-tetrahydro-3H-pyrazolo[4,3-f]isoquinolin-6-yl)-3-methoxyphenyl)-1-(3-fluoropropyl)azetidin-3-amine
Show/Hide
|
C26H32F3N5O
|
1
|
| 1 |
IC50 = 0.1 nM
|
|
|
|
CP0928285
|
5-fluoro-6-((6S,8R)-1-fluoro-8-methyl-7-(2,2,2-trifluoroethyl)-6,7,8,9-tetrahydro-3H-pyrazolo[4,3-f]isoquinolin-6-yl)-N-(1-(3-fluoropropyl)azetidin-3-yl)pyridin-3-amine
Show/Hide
|
C24H26F6N6
|
1
|
| 1 |
IC50 = 0.1 nM
|
|
|
|
CP0544794
|
6-(2,4-dichlorophenyl)-5-[3,5-difluoro-4-[[1-(3-fluoropropyl)azetidin-3-ylidene]methyl]phenyl]-8,9-dihydro-7H-benzo[7]annulene-2-carboxylic acid;hydrochloride
Show/Hide
|
C31H27Cl3F3NO2
|
1
|
| 1 |
IC50 = 0.1 nM
|
|
|
|
CP0567911
|
6-[2-chloro-4-(trifluoromethyl)phenyl]-5-[4-[[1-(3-fluoropropyl)azetidin-3-ylidene]methyl]phenyl]-8,9-dihydro-7H-benzo[7]annulene-2-carboxylic acid
Show/Hide
|
C32H28ClF4NO2
|
1
|
| 1 |
IC50 = 0.1 nM
|
|
|
|
CP0571275
|
6-[3-chloro-2-(trifluoromethyl)phenyl]-5-[4-[[1-(3-fluoropropyl)azetidin-3-yl]methyl]phenyl]-8,9-dihydro-7H-benzo[7]annulene-2-carboxylic acid
Show/Hide
|
C32H30ClF4NO2
|
1
|
| 1 |
IC50 = 0.1 nM
|
|
|
|
CP0576334
|
6-(2,4-dichloro-3-fluorophenyl)-5-[4-[[1-(3-fluoropropyl)azetidin-3-yl]methyl]phenyl]-8,9-dihydro-7H-benzo[7]annulene-2-carboxylic acid;hydrochloride
Show/Hide
|
C31H30Cl3F2NO2
|
1
|
| 1 |
IC50 = 0.1 nM
|
|
|
|
CP0579280
|
6-(3-chloro-2-methylphenyl)-5-[4-[[1-(3-fluoropropyl)azetidin-3-yl]methyl]phenyl]-8,9-dihydro-7H-benzo[7]annulene-2-carboxylic acid;hydrochloride
Show/Hide
|
C32H34Cl2FNO2
|
1
|
| 1 |
IC50 = 0.1 nM
|
|
|
|
CP0579883
|
5-[4-[[1-(3-fluoropropyl)azetidin-3-yl]methyl]phenyl]-6-[3-fluoro-2-(trifluoromethyl)phenyl]-8,9-dihydro-7H-benzo[7]annulene-2-carboxylic acid
Show/Hide
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C32H30F5NO2
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1
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| 1 |
IC50 = 0.1 nM
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CP0903483
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N-((S)-1-(3-Fluoropropyl)pyrrolidin-3-yl)-6-((6S,8R)-8-methyl-7-(2,2,2-trifluoroethyl)-6,7,8,9-tetrahydro-3H-pyrazolo[4,3-f]isoquinolin-6-yl)pyridin-3-amine
Show/Hide
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C25H30F4N6
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1
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| 1 |
IC50 = 0.1259 nM
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CP0910557
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(6S,8R)-6-(2,6-Difluoro-4-(2-(3-(fluoromethyl)azetidin-1-yl)ethoxy)phenyl)-7-(2-fluoro-2-methylpropyl)-8-methyl-6,7,8,9-tetrahydro-3H-pyrazolo[4,3-f]isoquinoline
Show/Hide
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C27H32F4N4O
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1
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| 1 |
IC50 = 0.1259 nM
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CP0910623
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(6S,8R)-7-((1-Fluorocyclopropyl)methyl)-6-(4-(2-(3-(fluoromethyl)azetidin-1-yl)ethoxy)-2-methoxyphenyl)-8-methyl-6,7,8,9-tetrahydro-3H-pyrazolo[4,3-f]isoquinoline
Show/Hide
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C28H34F2N4O2
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1
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| 1 |
IC50 = 0.1259 nM
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CP0910622
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CAMIZESTRANT
Show/Hide
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C24H28F4N6
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4
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| 1 |
IC50 = 0.1259 nM
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| 2 |
IC50 = 0.1585 nM
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| 3 |
IC50 = 6.31 nM
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| 4 |
IC50 > 316.23 nM
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CP0955784
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5-fluoro-N-(1-(3-fluoropropyl)azetidin-3-yl)-6-((6S,8R)-8-methyl-7-(2,2,3-trifluoropropyl)-6,7,8,9-tetrahydro-3H-pyrazolo[4,3-f]isoquinolin-6-yl)pyridin-3-amine
Show/Hide
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C25H29F5N6
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1
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| 1 |
IC50 = 0.1259 nM
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CP0188526
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(E)-3-[3,5-difluoro-4-[(1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-1,3,4,9-tetrahydropyrido[3,4-b]indol-1-yl]phenyl]prop-2-enoic acid
Show/Hide
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C25H25F3N2O2
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4
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| 1 |
IC50 = 0.138 nM
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| 2 |
IC50 = 0.18 nM
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| 3 |
IC50 = 0.2089 nM
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| 4 |
IC50 = 0.3162 nM
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CP0870595
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(1R,3R)-1-(4-(1-allylazetidin-3-yloxy)-2,6-difluorophenyl)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole
Show/Hide
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C28H32F3N3O
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1
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| 1 |
IC50 = 0.15 nM
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CP0903484
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(6S,8R)-7-(2-Fluoro-2-methylpropyl)-6-(4-(2-(3-(fluoromethyl)azetidin-1-yl)ethoxy)-2-methoxyphenyl)-8-methyl-6,7,8,9-tetrahydro-3H-pyrazolo[4,3-f]isoquinoline
Show/Hide
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C28H36F2N4O2
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1
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| 1 |
IC50 = 0.1585 nM
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CP0911491
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(6R,8R)-6-(4-(2-(3-(Fluoromethyl)azetidin-1-yl)ethoxy)phenyl)-7-isobutyl-8-methyl-6,7,8,9-tetrahydro-3H-pyrazolo[4,3-f]isoquinoline
Show/Hide
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C27H35FN4O
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1
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| 1 |
IC50 = 0.1585 nM
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CP0916133
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N-(1-(3-Fluoropropyl)azetidin-3-yl)-6-((6S,8R)-8-methyl-7-(2,2,2-trifluoroethyl)-6,7,8,9-tetrahydro-3H-pyrrolo[3,2-f]isoquinolin-6-yl)pyridin-3-amine
Show/Hide
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C25H29F4N5
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1
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| 1 |
IC50 = 0.1585 nM
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CP0382937
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(2S)-3-(4,4-difluorocyclohexyl)-2-[4-[2-[3-(fluoromethyl)azetidin-1-yl]ethoxy]phenyl]-4-methyl-2H-chromen-6-ol
Show/Hide
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C28H32F3NO3
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1
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| 1 |
IC50 = 0.17 nM
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CP0901632
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(1R,3R)-1-(4-(1-(3-chloropropyl)azetidin-3-yloxy)-2,6-difluorophenyl)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole
Show/Hide
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C28H33ClF3N3O
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1
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| 1 |
IC50 = 0.17 nM
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CP0948398
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(1R,3R)-1-(2,6-difluoro-4-(1-(2-fluoroethyl)azetidin-3-yloxy)phenyl)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole
Show/Hide
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C27H31F4N3O
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1
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| 1 |
IC50 = 0.18 nM
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CP0901631
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(1R,3R)-1-(2,6-difluoro-4-(2-(3-methylazetidin-1-yl)ethoxy)phenyl)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole
Show/Hide
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C28H34F3N3O
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1
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| 1 |
IC50 = 0.19 nM
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CP0569928
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(E)-3-[4-[(6S,8R)-7-(2,2-difluoropropyl)-8-methyl-3,6,8,9-tetrahydropyrazolo[4,3-f]isoquinolin-6-yl]-3-fluoro-5-methoxyphenyl]prop-2-enoic acid
Show/Hide
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C24H24F3N3O3
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1
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| 1 |
IC50 = 0.1995 nM
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CP0871672
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N-(4-((6S,8R)-7-(2-Fluoro-2-methylpropyl)-8-methyl-6,7,8,9-tetrahydro-3H-pyrazolo[4,3-f]isoquinolin-6-yl)-3-methoxyphenyl)-1-(3-fluoropropyl)azetidin-3-amine
Show/Hide
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C28H37F2N5O
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1
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| 1 |
IC50 = 0.1995 nM
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CP0903485
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(6S,8R)-6-(2,6-Difluoro-4-(2-(3-(fluoromethyl)azetidin-1-yl)ethoxy)phenyl)-7-isobutyl-8-methyl-6,7,8,9-tetrahydro-3H-pyrazolo[4,3-f]isoquinoline
Show/Hide
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C27H33F3N4O
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1
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| 1 |
IC50 = 0.1995 nM
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CP0911485
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N-(1-(3-Fluoropropyl)azetidin-3-yl)-N-methyl-6-((6S,8R)-8-methyl-7-(2,2,2-trifluoroethyl)-6,7,8,9-tetrahydro-3H-pyrazolo[4,3-f]isoquinolin-6-yl)pyridin-3-amine
Show/Hide
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C25H30F4N6
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1
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| 1 |
IC50 = 0.1995 nM
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CP0944988
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2,2-Difluoro-3-((6S,8R)-6-(4-((1-(3-fluoropropyl)azetidin-3-yl)amino)-2-methoxyphenyl)-8-methyl-3,6,8,9-tetrahydro-7H-pyrazolo[4,3-f]isoquinolin-7-yl)propan-1-ol
Show/Hide
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C27H34F3N5O2
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1
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| 1 |
IC50 = 0.1995 nM
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CP0898623
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2-fluoro-N-(1-(3-fluoropropyl)azetidin-3-yl)-6-((6S,8R)-8-methyl-7-(2,2,2-trifluoroethyl)-6,7,8,9-tetrahydro-3H-pyrazolo[4,3-f]isoquinolin-6-yl)pyridin-3-amine
Show/Hide
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C24H27F5N6
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1
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| 1 |
IC50 = 0.1995 nM
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CP0942944
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6-((6S,8R)-4-fluoro-8-methyl-7-(2,2,2-trifluoroethyl)-6,7,8,9-tetrahydro-3H-pyrazolo[4,3-f]isoquinolin-6-yl)-N-(1-(3-fluoropropyl)azetidin-3-yl)pyridin-3-amine
Show/Hide
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C24H27F5N6
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1
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| 1 |
IC50 = 0.1995 nM
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CP0447044
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(E)-3-(4-((2-(2-(1,1- difluoroethyl)phenyl)-6- hydroxybenzo[b] thiophen-3- yl)oxy)phenyl)acrylic acid
Show/Hide
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C25H18F2O4S
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2
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| 1 |
IC50 = 0.2 nM
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| 2 |
IC50 = 11 nM
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CP0457842
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US10058534, 139
Show/Hide
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C25H17F3O4S
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3
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| 1 |
IC50 = 0.2 nM
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| 2 |
IC50 = 6 nM
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| 3 |
IC50 = 8.9 nM
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CP0383466
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5-[4-[(3S)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-6-(4-hydroxycyclohexyl)-8,9-dihydro-7H-benzo[7]annulen-2-ol
Show/Hide
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C30H38FNO3
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1
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| 1 |
IC50 = 0.2 nM
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CP0394349
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5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-6-(4- methoxy- 2-methyl- phenyl)-8,9- dihydro- 7H- benzo[7]- annulen-2-ol1-fluoro-6- (2-fluoro-4- methyl- phenyl)-5- [4-[(3S)-1- (3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2-ol
Show/Hide
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C32H36FNO3
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1
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| 1 |
IC50 = 0.2 nM
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CP0532888
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6-[4- (difluoro- methoxy)-2- fluoro- phenyl]-1- fluoro-5-[4- [(3S)-1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2-ol
Show/Hide
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C31H30F5NO3
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1
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| 1 |
IC50 = 0.2 nM
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CP0271286
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3-(3-hydroxyphenyl)-4-methyl-2-[4-[(2S)-2-[(3R)-3-methylpyrrolidin-1-yl]propoxy]phenyl]-2H-chromen-6-ol
Show/Hide
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C30H33NO4
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1
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| 1 |
IC50 = 0.2 nM
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CP0427270
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3-(3-hydroxyphenyl)-4-methyl-2-[4-(2-piperidin-1-ylethoxy)phenyl]-2H-chromen-6-ol
Show/Hide
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C29H31NO4
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1
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| 1 |
IC50 = 0.2 nM
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CP0435373
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3-(3-hydroxyphenyl)-4-methyl-2-[4-[2-[(3S)-3-methylpyrrolidin-1-yl]ethoxy]phenyl]-2H-chromen-6-ol
Show/Hide
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C29H31NO4
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1
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| 1 |
IC50 = 0.2 nM
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CP0435374
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3-(3-hydroxyphenyl)-4-methyl-2-[4-[(2S)-2-piperidin-1-ylpropoxy]phenyl]-2H-chromen-6-ol
Show/Hide
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C30H33NO4
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1
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| 1 |
IC50 = 0.2 nM
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CP0457515
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3-(3-hydroxyphenyl)-4-methyl-2-[4-[2-(4-methylpiperidin-1-yl)ethoxy]phenyl]-2H-chromen-6-ol
Show/Hide
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C30H33NO4
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1
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| 1 |
IC50 = 0.2 nM
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CP0466428
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2-[4-[(2S)-2-(azepan-1-yl)propoxy]phenyl]-3-(3-hydroxyphenyl)-4-methyl-2H-chromen-6-ol
Show/Hide
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C31H35NO4
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1
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| 1 |
IC50 = 0.2 nM
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CP0466443
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2-[4-[2-(azepan-1-yl)ethoxy]phenyl]-3-(3-hydroxyphenyl)-4-methyl-2H-chromen-6-ol
Show/Hide
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C30H33NO4
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1
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| 1 |
IC50 = 0.2 nM
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CP0484718
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3-(3-hydroxyphenyl)-4-methyl-2-[4-[(2S)-2-[(3S)-3-methylpyrrolidin-1-yl]propoxy]phenyl]-2H-chromen-6-ol
Show/Hide
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C30H33NO4
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1
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| 1 |
IC50 = 0.2 nM
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CP0484719
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3-(3-hydroxyphenyl)-4-methyl-2-[4-[(2R)-2-[(3S)-3-methylpyrrolidin-1-yl]propoxy]phenyl]-2H-chromen-6-ol
Show/Hide
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C30H33NO4
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1
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| 1 |
IC50 = 0.2 nM
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CP0548198
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3-(3-hydroxyphenyl)-4-methyl-2-[4-[(2S)-2-[(3R)-3-methylpyrrolidin-1-yl]propoxy]phenyl]-2H-chromen-7-ol
Show/Hide
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C30H33NO4
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1
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| 1 |
IC50 = 0.2 nM
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CP0455825
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2-[4-[2-[(2S)-2-(fluoromethyl)pyrrolidin-1-yl]ethoxy]phenyl]-3-(3-hydroxyphenyl)-4-methyl-2H-chromen-6-ol
Show/Hide
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C29H30FNO4
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1
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| 1 |
IC50 = 0.2 nM
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CP0455827
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2-[4-[(2S)-2-[3-(fluoromethyl)azetidin-1-yl]propoxy]phenyl]-3-(3-hydroxyphenyl)-4-methyl-2H-chromen-6-ol
Show/Hide
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C29H30FNO4
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1
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| 1 |
IC50 = 0.2 nM
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CP0470347
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2-[4-[2-[(3R)-3-(difluoromethyl)pyrrolidin-1-yl]ethoxy]phenyl]-3-(3-hydroxyphenyl)-4-methyl-2H-chromen-6-ol
Show/Hide
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C29H29F2NO4
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1
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| 1 |
IC50 = 0.2 nM
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CP0478997
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2-[4-[(2S)-2-[(3R)-3-(fluoromethyl)pyrrolidin-1-yl]propoxy]phenyl]-3-(3-hydroxyphenyl)-4-methyl-2H-chromen-6-ol
Show/Hide
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C30H32FNO4
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1
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| 1 |
IC50 = 0.2 nM
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CP0539421
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4-[2-[4-[2-[3-(fluoromethyl)azetidin-1-yl]ethoxy]phenyl]-6-hydroxy-4-methyl-2H-chromen-3-yl]benzonitrile
Show/Hide
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C29H27FN2O3
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1
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| 1 |
IC50 = 0.2 nM
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CP0434261
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(2S)-5-fluoro-2-[4-[2-[3-(fluoromethyl)azetidin-1-yl]ethoxy]phenyl]-3-(4-fluorophenyl)-4-methyl-2H-chromen-6-ol
Show/Hide
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C28H26F3NO3
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1
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| 1 |
IC50 = 0.2 nM
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CP0561772
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(2S)-2-[4-[2-[3-(fluoromethyl)azetidin-1-yl]ethoxy]phenyl]-3-[(E)-3-methoxyprop-1-enyl]-4-methyl-2H-chromen-6-ol
Show/Hide
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C26H30FNO4
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1
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| 1 |
IC50 = 0.2 nM
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CP0546149
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6-[2,5-bis(trifluoromethyl)phenyl]-5-[4-[[1-(3-fluoropropyl)azetidin-3-ylidene]methyl]phenyl]-8,9-dihydro-7H-benzo[7]annulene-2-carboxylic acid
Show/Hide
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C33H28F7NO2
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1
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| 1 |
IC50 = 0.2 nM
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CP0575832
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5-[4-[[1-(3,3-difluoropropyl)azetidin-3-ylidene]methyl]phenyl]-6-(4-fluoro-2-methylphenyl)-8,9-dihydro-7H-benzo[7]annulene-2-carboxylic acid
Show/Hide
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C32H30F3NO2
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1
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| 1 |
IC50 = 0.2 nM
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CP0575833
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6-(4-cyclopropyl-2-methylphenyl)-5-[4-[[1-(3-fluoropropyl)azetidin-3-ylidene]methyl]phenyl]-8,9-dihydro-7H-benzo[7]annulene-2-carboxylic acid
Show/Hide
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C35H36FNO2
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1
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| 1 |
IC50 = 0.2 nM
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CP0575834
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6-(2,4-dichlorophenyl)-5-[4-[[1-(3-fluoropropyl)azetidin-3-ylidene]methyl]phenyl]-8,9-dihydro-7H-benzo[7]annulen-2-ol
Show/Hide
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C30H28Cl2FNO
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1
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| 1 |
IC50 = 0.2 nM
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CP0571276
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5-[4-[[1-(3,3-difluoropropyl)azetidin-3-yl]methyl]phenyl]-6-[3-fluoro-2-(trifluoromethyl)phenyl]-8,9-dihydro-7H-benzo[7]annulene-2-carboxylic acid
Show/Hide
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C32H29F6NO2
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1
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| 1 |
IC50 = 0.2 nM
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CP0579884
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6-(cyclobutylmethyl)-5-[4-[[1-(3-fluoropropyl)azetidin-3-yl]methyl]phenyl]-8,9-dihydro-7H-benzo[7]annulene-2-carboxylic acid
Show/Hide
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C30H36FNO2
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1
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| 1 |
IC50 = 0.2 nM
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CP0867238
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(1R,3R)-1-(2,6-difluoro-4-((S)-2-((R)-3-(fluoromethyl)pyrrolidin-1-yl)propoxy)phenyl)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole
Show/Hide
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C30H37F4N3O
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1
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| 1 |
IC50 = 0.21 nM
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CP0148110
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(E)-3-[3,5-difluoro-4-[(1S,3R)-2-(2-fluoro-2-methylpropyl)-6-hydroxy-3-methyl-3,4-dihydro-1H-isoquinolin-1-yl]phenyl]prop-2-enoic acid
Show/Hide
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C23H24F3NO3
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1
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| 1 |
IC50 = 0.25 nM
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CP0421184
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(1R,3R)-1-[2,6-difluoro-4-[2-[3-(fluoromethyl)azetidin-1-yl]ethoxy]phenyl]-2-(2-fluoro-2-methylpropyl)-1,3-dimethyl-4,9-dihydro-3H-pyrido[3,4-b]indole
Show/Hide
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C29H35F4N3O
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1
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| 1 |
IC50 = 0.2512 nM
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CP0875488
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(E)-3-[3,5-Difluoro-4-[(6S,8R)-7-(2-fluoro-2-methyl-propyl)-8-methyl-3,6,8,9-tetrahydropyrazolo[4,3-f]isoquinolin-6-yl]phenyl]-prop-2-enoic Acid
Show/Hide
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C24H24F3N3O2
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5
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| 1 |
IC50 = 0.2512 nM
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| 2 |
IC50 = 0.7943 nM
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| 3 |
IC50 = 1 nM
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| 4 |
IC50 = 7.943 nM
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| 5 |
IC50 > 3162.28 nM
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CP0923250
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(6S,8R)-6-(4-(2-(3-(Fluoromethyl)azetidin-1-yl)ethoxy)-2-methoxyphenyl)-7-((3-fluorooxetan-3-yl)methyl)-8-methyl-6,7,8,9-tetrahydro-3H-pyrazolo[4,3-f]isoquinoline
Show/Hide
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C28H34F2N4O3
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1
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| 1 |
IC50 = 0.2512 nM
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CP0928283
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5-fluoro-N-(1-(3-fluoropropyl)azetidin-3-yl)-6-((6S,8R)-8-methyl-7-(2,2,2-trifluoroethyl)-6,7,8,9-tetrahydro-3H-pyrazolo[4,3-f]isoquinolin-6-yl)pyridin-3-amine
Show/Hide
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C24H27F5N6
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1
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| 1 |
IC50 = 0.2512 nM
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CP0434262
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(2S)-2-[4-[2-[3-(fluoromethyl)azetidin-1-yl]ethoxy]phenyl]-3-(4-hydroxycyclohexyl)-4-methyl-2H-chromen-6-ol
Show/Hide
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C28H34FNO4
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1
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| 1 |
IC50 = 0.28 nM
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CP0317549
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19-[4-(2-piperidin-1-ylethoxy)phenyl]-8,18-dioxatetracyclo[9.8.0.02,7.012,17]nonadeca-1(11),2(7),3,5,12(17),13,15-heptaene-5,15-diol
Show/Hide
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C30H31NO5
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2
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| 1 |
IC50 = 0.28 nM
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| 2 |
IC50 = 19 nM
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CP0464085
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(E)-3-(4-((2-(2-(1- fluoroethyl)phenyl)-6- hydroxybenzo[b] thiophen-3- yl)oxy)phenyl)acrylic acid
Show/Hide
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C25H19FO4S
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2
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| 1 |
IC50 = 0.3 nM
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| 2 |
IC50 = 25 nM
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CP0472900
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5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-6-(2- methyl- 1,3- benzo- xazol-6-yl)-8,9- dihydro- 7H- benzo[7]- annulen-2-ol
Show/Hide
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C32H33FN2O3
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1
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| 1 |
IC50 = 0.3 nM
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CP0472902
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6-(3-fluoro- 4-methoxy- phenyl)-5- [4-[(3S)-1- (3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2-ol
Show/Hide
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C31H33F2NO3
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1
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| 1 |
IC50 = 0.3 nM
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CP0386906
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3-(3-Hydroxyphenyl)-4-methyl-2-(4-(2-(3-methylazetidin-1-yl)ethoxy)phenyl)-2H-chromen-6-ol
Show/Hide
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C28H29NO4
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1
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| 1 |
IC50 = 0.3 nM
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CP0393901
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3-(3-hydroxyphenyl)-4-methyl-2-[4-[(2R)-2-pyrrolidin-1-ylpropoxy]phenyl]-2H-chromen-6-ol
Show/Hide
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C29H31NO4
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1
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| 1 |
IC50 = 0.3 nM
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CP0476731
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3-(3-hydroxyphenyl)-4-methyl-2-[4-[(2R)-2-[(3R)-3-methylpyrrolidin-1-yl]propoxy]phenyl]-2H-chromen-6-ol
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C30H33NO4
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1
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| 1 |
IC50 = 0.3 nM
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CP0520057
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2-[4-[2-(azetidin-1-yl)ethoxy]phenyl]-3-(3-hydroxyphenyl)-4-methyl-2H-chromen-6-ol
Show/Hide
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C27H27NO4
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1
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| 1 |
IC50 = 0.3 nM
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CP0552415
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3-(4-hydroxyphenyl)-4-methyl-2-[4-[(2S)-2-[(3R)-3-methylpyrrolidin-1-yl]propoxy]phenyl]-2H-chromen-7-ol
Show/Hide
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C30H33NO4
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1
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| 1 |
IC50 = 0.3 nM
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CP0455826
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3-(3-hydroxyphenyl)-2-[4-[2-[(3R)-3-(methoxymethyl)pyrrolidin-1-yl]ethoxy]phenyl]-4-methyl-2H-chromen-6-ol
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C30H33NO5
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1
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| 1 |
IC50 = 0.3 nM
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CP0574300
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(-)-2-(4-(2-(3-(Fluoromethyl)azetidin-1-yl)ethoxy)phenyl)-3-(3-hydroxyphenyl)-4-methyl-2H-chromen-6-ol
Show/Hide
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C28H28FNO4
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1
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| 1 |
IC50 = 0.3 nM
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CP0540898
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(2S)-3-(6-aminopyridin-3-yl)-2-[4-[2-[3-(fluoromethyl)azetidin-1-yl]ethoxy]phenyl]-4-methyl-2H-chromen-6-ol
Show/Hide
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C27H28FN3O3
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1
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| 1 |
IC50 = 0.3 nM
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CP0479595
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(E)-3-[4-[(6S,8R)-7-(2,2-difluoropropyl)-8-methyl-3,6,8,9-tetrahydropyrazolo[4,3-f]isoquinolin-6-yl]-2-fluoro-5-methoxyphenyl]prop-2-enoic acid
Show/Hide
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C24H24F3N3O3
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1
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| 1 |
IC50 = 0.3162 nM
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CP0563688
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(E)-3-[4-[(6R,8R)-7-(2-fluoro-2-methylpropyl)-8-methyl-3,6,8,9-tetrahydropyrazolo[4,3-f]isoquinolin-6-yl]phenyl]prop-2-enoic acid
Show/Hide
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C24H26FN3O2
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1
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| 1 |
IC50 = 0.3162 nM
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CP0871671
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6-((6S,8R)-7-(2-Fluoro-2-methylpropyl)-8-methyl-6,7,8,9-tetrahydro-3H-pyrazolo[4,3-f]isoquinolin-6-yl)-N-(1-(3-fluoropropyl)azetidin-3-yl)pyridin-3-amine
Show/Hide
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C26H34F2N6
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1
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| 1 |
IC50 = 0.3162 nM
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CP0910628
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N-(4-((6S,8R)-7-((1-Fluorocyclopropyl)methyl)-8-methyl-6,7,8,9-tetrahydro-3H-pyrazolo[4,3-f]isoquinolin-6-yl)-3-methoxyphenyl)-1-(3-fluoropropyl)azetidin-3-amine
Show/Hide
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C28H35F2N5O
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1
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| 1 |
IC50 = 0.3162 nM
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CP0911390
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6-((6S,8R)-7-(2,2-Difluoropropyl)-8-methyl-6,7,8,9-tetrahydro-3H-pyrazolo[4,3-f]isoquinolin-6-yl)-N-(1-(3-fluoropropyl)azetidin-3-yl)pyridin-3-amine
Show/Hide
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C25H31F3N6
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1
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| 1 |
IC50 = 0.3162 nM
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CP0911489
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3-Fluoro-N-(2-(4-((6S,8R)-7-((1-fluorocyclopropyl)methyl)-8-methyl-6,7,8,9-tetrahydro-3H-pyrazolo[4,3-f]isoquinolin-6-yl)-3-methoxyphenoxy)ethyl)propan-1-amine
Show/Hide
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C27H34F2N4O2
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1
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| 1 |
IC50 = 0.3162 nM
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CP0913177
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6-((6S,8R)-7-(2,2-Difluoroethyl)-8-methyl-6,7,8,9-tetrahydro-3H-pyrazolo[4,3-f]isoquinolin-6-yl)-N-(1-(3-fluoropropyl)azetidin-3-yl)pyridin-3-amine
Show/Hide
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C24H29F3N6
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1
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| 1 |
IC50 = 0.3162 nM
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CP0429289
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(E)-3-[3,5-difluoro-4-[(1S,3R)-2-[(2S)-3-fluoro-2-methylpropyl]-6-hydroxy-3-methyl-3,4-dihydro-1H-isoquinolin-1-yl]phenyl]prop-2-enoic acid
Show/Hide
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C23H24F3NO3
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1
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| 1 |
IC50 = 0.37 nM
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CP0864279
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(1R,3R)-1-(2,6-difluoro-4-(2-(3-fluoro-3-(fluoromethyl)azetidin-1-yl)ethoxy)phenyl)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole
Show/Hide
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C28H32F5N3O
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1
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| 1 |
IC50 = 0.38 nM
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CP0867243
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(1R,3R)-1-(2,6-difluoro-4-(1-(4-fluorobutyl)azetidin-3-yloxy)phenyl)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole
Show/Hide
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C29H35F4N3O
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1
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| 1 |
IC50 = 0.39 nM
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CP0551068
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(E)-3-[4-[(6S,8R)-7-(2,2-difluoropropyl)-8-methyl-3,6,8,9-tetrahydropyrazolo[4,3-f]isoquinolin-6-yl]-3,5-difluorophenyl]prop-2-enoic acid
Show/Hide
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C23H21F4N3O2
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1
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| 1 |
IC50 = 0.3981 nM
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CP0910590
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(6S,8R)-6-(5-(2-(3-(Fluoromethyl)azetidin-1-yl)ethoxy)pyridin-2-yl)-8-methyl-7-(2,2,2-trifluoroethyl)-6,7,8,9-tetrahydro-3H-pyrazolo[4,3-f]isoquinoline
Show/Hide
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C24H27F4N5O
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1
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| 1 |
IC50 = 0.3981 nM
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CP0911947
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(6S,8R)-6-(5-(((S)-1-(3-Fluoropropyl)pyrrolidin-3-yl)oxy)pyridin-2-yl)-8-methyl-7-(2,2,2-trifluoroethyl)-6,7,8,9-tetrahydro-3H-pyrazolo[4,3-f]isoquinoline
Show/Hide
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C25H29F4N5O
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1
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| 1 |
IC50 = 0.3981 nM
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CP0916134
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(6S,8R)-6-(5-(2-(3-(Fluoromethyl)azetidin-1-yl)ethoxy)pyridin-2-yl)-7-isobutyl-8-methyl-6,7,8,9-tetrahydro-3H-pyrazolo[4,3-f]isoquinoline
Show/Hide
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C26H34FN5O
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1
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| 1 |
IC50 = 0.3981 nM
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CP0916889
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(6S,8R)-7-((1-Fluorocyclopropyl)methyl)-6-(4-((1-(3-fluoropropyl)azetidin-3-yl)oxy)-2-methoxyphenyl)-8-methyl-6,7,8,9-tetrahydro-3H-pyrazolo[4,3-f]isoquinoline
Show/Hide
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C28H34F2N4O2
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1
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| 1 |
IC50 = 0.3981 nM
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CP0953969
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(6S,8R)-7-((1-Fluorocyclopropyl)methyl)-6-(5-(2-(3-(fluoromethyl)azetidin-1-yl)ethoxy)pyridin-2-yl)-8-methyl-6,7,8,9-tetrahydro-3H-pyrazolo[4,3-f]isoquinoline
Show/Hide
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C26H31F2N5O
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1
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| 1 |
IC50 = 0.3981 nM
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CP0226160
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(E)-3-[4-[(1R,3R)-2-[(2S)-3-fluoro-2-methylpropyl]-6-hydroxy-3-methyl-3,4-dihydro-1H-isoquinolin-1-yl]phenyl]prop-2-enoic acid
Show/Hide
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C23H26FNO3
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1
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| 1 |
IC50 = 0.4 nM
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CP0508373
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(E)-3-[4-[2-[2-fluoro-4-(2-methylpropyl)phenyl]-6-hydroxy-1-methyl-3,4-dihydroisoquinolin-1-yl]phenyl]prop-2-enoic acid
Show/Hide
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C29H30FNO3
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2
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| 1 |
IC50 = 0.4 nM
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| 2 |
IC50 = 7 nM
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CP0561514
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(E)-3-[4-[2-(4-cyclopropylphenyl)-6-hydroxy-1-methyl-3,4-dihydroisoquinolin-1-yl]phenyl]prop-2-enoic acid
Show/Hide
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C28H27NO3
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2
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| 1 |
IC50 = 0.4 nM
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| 2 |
IC50 = 39 nM
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CP0476181
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(E)-3-(4-((6-hydroxy-2- (2-isopropylphenyl)- benzo[b]thiophen-3- yl)oxy)phenyl)acrylic acid
Show/Hide
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C26H22O4S
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2
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| 1 |
IC50 = 0.4 nM
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| 2 |
IC50 = 6 nM
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CP0393899
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3-(3-hydroxyphenyl)-4-methyl-2-[4-[(2S)-2-pyrrolidin-1-ylpropoxy]phenyl]-2H-chromen-6-ol
Show/Hide
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C29H31NO4
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1
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| 1 |
IC50 = 0.4 nM
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CP0412529
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4-methyl-2-[4-[(2S)-2-[(3R)-3-methylpyrrolidin-1-yl]propoxy]phenyl]-3-phenyl-2H-chromen-6-ol
Show/Hide
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C30H33NO3
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1
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| 1 |
IC50 = 0.4 nM
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CP0412530
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3-(4-fluorophenyl)-4-methyl-2-[4-[(2S)-2-[(3R)-3-methylpyrrolidin-1-yl]propoxy]phenyl]-2H-chromen-6-ol
Show/Hide
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C30H32FNO3
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1
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| 1 |
IC50 = 0.4 nM
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CP0435372
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3-(3-hydroxyphenyl)-4-methyl-2-[4-[2-[(3R)-3-methylpyrrolidin-1-yl]ethoxy]phenyl]-2H-chromen-6-ol
Show/Hide
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C29H31NO4
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1
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| 1 |
IC50 = 0.4 nM
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CP0466442
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3-(3-hydroxyphenyl)-4-methyl-2-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-2H-chromen-6-ol
Show/Hide
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C28H29NO4
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1
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| 1 |
IC50 = 0.4 nM
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CP0458081
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2-[4-[2-[3-(fluoromethyl)azetidin-1-yl]ethoxy]phenyl]-3-(4-fluorophenyl)-4-methyl-2H-chromen-6-ol
Show/Hide
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C28H27F2NO3
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1
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| 1 |
IC50 = 0.4 nM
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CP0705277
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N-(4-(4-((1r,3r,5R,7S)-adamantan-2-ylidene(4-hydroxyphenyl)methyl)phenoxy)butyl)cyclohexanecarboxamide
Show/Hide
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C34H43NO3
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1
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| 1 |
IC50 = 0.4 nM
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CP0206907
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(E)-3-[3,5-difluoro-4-[(1R,3R)-3-methyl-2-(2-methylpropyl)-1,3,4,9-tetrahydropyrido[3,4-b]indol-1-yl]phenyl]prop-2-enoic acid
Show/Hide
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C25H26F2N2O2
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1
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| 1 |
IC50 = 0.4169 nM
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CP0402277
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(2S)-2-[4-[2-[3-(fluoromethyl)azetidin-1-yl]ethoxy]phenyl]-3-(4-fluorophenyl)-4-methyl-2H-chromen-8-ol
Show/Hide
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C28H27F2NO3
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1
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| 1 |
IC50 = 0.42 nM
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CP0448672
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(E)-3-[4-[6-hydroxy-1-methyl-2-[4-(2,2,2-trifluoroethyl)phenyl]-3,4-dihydroisoquinolin-1-yl]phenyl]prop-2-enoic acid
Show/Hide
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C27H24F3NO3
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2
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| 1 |
IC50 = 0.5 nM
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| 2 |
IC50 = 27 nM
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CP0435377
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3-(3-fluorophenyl)-4-methyl-2-[4-[(2S)-2-[(3R)-3-methylpyrrolidin-1-yl]propoxy]phenyl]-2H-chromen-6-ol
Show/Hide
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C30H32FNO3
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1
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| 1 |
IC50 = 0.5 nM
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CP0666264
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tert-butyl (1-((4-(4-((1r,3r,5R,7S)-adamantan-2-ylidene(4-hydroxyphenyl)methyl)phenoxy)butyl)amino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl)carbamate
Show/Hide
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C43H51N3O5
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1
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| 1 |
IC50 = 0.5 nM
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CP0753587
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(1R,4R,5S)-N-[4-[4-[2-adamantylidene-(4-hydroxyphenyl)methyl]phenoxy]butyl]bicyclo[2.2.1]hept-2-ene-5-carboxamide
Show/Hide
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C35H41NO3
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1
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| 1 |
IC50 = 0.5 nM
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CP0402296
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(2S)-4-ethyl-2-[4-[2-[3-(fluoromethyl)azetidin-1-yl]ethoxy]phenyl]-3-(3-hydroxyphenyl)-2H-chromen-6-ol
Show/Hide
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C29H30FNO4
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1
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| 1 |
IC50 = 0.5 nM
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CP0402298
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(2S)-2-[4-[2-[3-(fluoromethyl)azetidin-1-yl]ethoxy]phenyl]-3-(3-hydroxyphenyl)-2H-chromen-6-ol
Show/Hide
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C27H26FNO4
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1
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| 1 |
IC50 = 0.5 nM
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CP0556568
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(2S)-2-[4-[2-[3-(fluoromethyl)azetidin-1-yl]ethoxy]phenyl]-4-methyl-3-pyridin-3-yl-2H-chromen-6-ol
Show/Hide
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C27H27FN2O3
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1
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| 1 |
IC50 = 0.5 nM
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CP0911487
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2,2-Difluoro-3-((6S,8R)-6-(5-((1-(3-fluoropropyl)azetidin-3-yl)amino)pyridin-2-yl)-8-methyl-3,6,8,9-tetrahydro-7H-pyrazolo[4,3-f]isoquinolin-7-yl)propan-1-ol
Show/Hide
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C25H31F3N6O
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1
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| 1 |
IC50 = 0.5012 nM
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CP0911490
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(6S,8R)-6-(4-(2-(3-(Fluoromethyl)azetidin-1-yl)ethoxy)-2-methoxyphenyl)-7-isobutyl-8-methyl-6,7,8,9-tetrahydro-3H-pyrazolo[4,3-f]isoquinoline
Show/Hide
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C28H37FN4O2
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1
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| 1 |
IC50 = 0.5012 nM
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CP0911492
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(S)-6-(8,8-Dimethyl-7-(2,2,2-trifluoroethyl)-6,7,8,9-tetrahydro-3H-pyrazolo[4,3-f]isoquinolin-6-yl)-N-(1-(3-fluoropropyl)azetidin-3-yl)pyridin-3-amine
Show/Hide
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C25H30F4N6
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1
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| 1 |
IC50 = 0.5012 nM
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CP0911948
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(6S,8R)-7-(2,2-Difluoroethyl)-6-(5-(2-(3-(fluoromethyl)azetidin-1-yl)ethoxy)pyridin-2-yl)-8-methyl-6,7,8,9-tetrahydro-3H-pyrazolo[4,3-f]isoquinoline
Show/Hide
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C24H28F3N5O
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1
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| 1 |
IC50 = 0.5012 nM
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CP0966367
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6-((6S,8S)-7-(2,2-difluoroethyl)-8-(difluoromethyl)-6,7,8,9-tetrahydro-3H-pyrazolo[4,3-f]isoquinolin-6-yl)-N-(1-(3-fluoropropyl)azetidin-3-yl)pyridin-3-amine
Show/Hide
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C24H27F5N6
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1
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| 1 |
IC50 = 0.5012 nM
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CP0870597
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(1R,3R)-1-(2,6-difluoro-4-(1-((1-(fluoromethyl)cyclopropyl)methyl)azetidin-3-yloxy)phenyl)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole
Show/Hide
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C30H35F4N3O
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1
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| 1 |
IC50 = 0.52 nM
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CP0667874
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(E)-3-(4-(((1r,3r,5R,7S)-Adamantan-2-ylidene)(4-hydroxyphenyl)-methyl)phenyl)-N-(3-hydroxypropyl)acrylamide
Show/Hide
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C29H33NO3
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2
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| 1 |
IC50 = 0.53 nM
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| 2 |
IC50 = 50 nM
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CP0953362
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(1R,3R)-1-(2,6-difluoro-4-(1-(((1R,2S)-2-fluorocyclopropyl)methyl)azetidin-3-yloxy)phenyl)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole
Show/Hide
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C29H33F4N3O
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1
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| 1 |
IC50 = 0.55 nM
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CP0901630
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(1R,3R)-1-(2,6-difluoro-4-(1-(((1R,2R)-2-fluorocyclopropyl)methyl)azetidin-3-yloxy)phenyl)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole
Show/Hide
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C29H33F4N3O
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1
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| 1 |
IC50 = 0.56 nM
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CP0402278
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(2S)-7-fluoro-2-[4-[2-[3-(fluoromethyl)azetidin-1-yl]ethoxy]phenyl]-3-(4-fluorophenyl)-4-methyl-2H-chromen-6-ol
Show/Hide
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C28H26F3NO3
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1
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| 1 |
IC50 = 0.58 nM
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CP0448673
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(E)-3-[4-[2-(4-cyclobutylphenyl)-6-hydroxy-1-methyl-3,4-dihydroisoquinolin-1-yl]phenyl]prop-2-enoic acid
Show/Hide
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C29H29NO3
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2
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| 1 |
IC50 = 0.6 nM
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| 2 |
IC50 = 53 nM
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CP0558792
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(E)-3-[4-[2-[4-(cyclopropylmethyl)phenyl]-6-hydroxy-1-methyl-3,4-dihydroisoquinolin-1-yl]phenyl]prop-2-enoic acid
Show/Hide
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C29H29NO3
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2
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| 1 |
IC50 = 0.6 nM
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| 2 |
IC50 = 6.5 nM
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CP0431918
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(E)-3-[4-[(6R,8R)-8-methyl-7-(2-methylpropyl)-3,6,8,9-tetrahydropyrazolo[4,3-f]isoquinolin-6-yl]phenyl]prop-2-enoic acid
Show/Hide
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C24H27N3O2
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1
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| 1 |
IC50 = 0.631 nM
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CP0446733
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(E)-3-[3,5-difluoro-4-[(6S,8R)-7-(2-fluoro-2-methylpropyl)-6,8-dimethyl-8,9-dihydro-3H-pyrazolo[4,3-f]isoquinolin-6-yl]phenyl]prop-2-enoic acid
Show/Hide
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C25H26F3N3O2
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1
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| 1 |
IC50 = 0.631 nM
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CP0446735
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(E)-3-[4-[(6S,8R)-7-(2-fluoro-2-methylpropyl)-8-methyl-3,6,8,9-tetrahydropyrazolo[4,3-f]isoquinolin-6-yl]-3-methoxyphenyl]prop-2-enoic acid
Show/Hide
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C25H28FN3O3
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1
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| 1 |
IC50 = 0.631 nM
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CP0911488
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6-((6S,8R)-7-((1-Fluorocyclopropyl)methyl)-8-methyl-6,7,8,9-tetrahydro-3H-pyrazolo[4,3-f]isoquinolin-6-yl)-N-(1-(3-fluoropropyl)azetidin-3-yl)pyridin-3-amine
Show/Hide
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C26H32F2N6
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1
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| 1 |
IC50 = 0.631 nM
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CP0911950
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N1-(3-Fluoropropyl)-N2-(6-((6S,8R)-8-methyl-7-(2,2,2-trifluoroethyl)-6,7,8,9-tetrahydro-3H-pyrazolo[4,3-f]isoquinolin-6-yl)pyridin-3-yl)ethane-1,2-diamine
Show/Hide
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C23H28F4N6
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1
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| 1 |
IC50 = 0.631 nM
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CP0539259
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5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-6-(3- hydroxy- phenyl)-8,9- dihydro- 7H- benzo[7]- annulen-2-ol
Show/Hide
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C30H32FNO3
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1
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| 1 |
IC50 = 0.7 nM
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CP0513444
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3-[6-hydroxy-4-methyl-2-[4-[(2S)-2-[(3R)-3-methylpyrrolidin-1-yl]propoxy]phenyl]-2H-chromen-3-yl]benzonitrile
Show/Hide
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C31H32N2O3
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1
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| 1 |
IC50 = 0.7 nM
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CP0656696
|
SID50106949
Show/Hide
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C28H28ClNO4S
|
1
|
| 1 |
IC50 = 0.72 nM
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CP0431916
|
(E)-3-[3,5-difluoro-4-[(6S,8R)-8-methyl-7-(2-methylpropyl)-3,6,8,9-tetrahydropyrazolo[4,3-f]isoquinolin-6-yl]phenyl]prop-2-enoic acid
Show/Hide
|
C24H25F2N3O2
|
1
|
| 1 |
IC50 = 0.7943 nM
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|
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CP0535362
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(E)-3-[4-[(6S,8R)-7-(2,2-difluoropropyl)-6,8-dimethyl-8,9-dihydro-3H-pyrazolo[4,3-f]isoquinolin-6-yl]-3,5-difluorophenyl]prop-2-enoic acid
Show/Hide
|
C24H23F4N3O2
|
1
|
| 1 |
IC50 = 0.7943 nM
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CP0911483
|
N-((S)-1-(3-Fluoropropyl)pyrrolidin-3-yl)-N-methyl-6-((6S,8R)-8-methyl-7-(2,2,2-trifluoroethyl)-6,7,8,9-tetrahydro-3H-pyrazolo[4,3-f]isoquinolin-6-yl)pyridin-3-amine
Show/Hide
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C26H32F4N6
|
1
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| 1 |
IC50 = 0.7943 nM
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CP0911486
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(S)-6-(7-(2,2-Difluoroethyl)-8,8-dimethyl-6,7,8,9-tetrahydro-3H-pyrazolo[4,3-f]isoquinolin-6-yl)-N-(1-(3-fluoropropyl)azetidin-3-yl)pyridin-3-amine
Show/Hide
|
C25H31F3N6
|
1
|
| 1 |
IC50 = 0.7943 nM
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CP0447306
|
(E)-3-[4-[6-hydroxy-1-methyl-2-[4-(2-methylpropyl)phenyl]-3,4-dihydroisoquinolin-1-yl]phenyl]prop-2-enoic acid
Show/Hide
|
C29H31NO3
|
2
|
| 1 |
IC50 = 0.8 nM
|
|
|
| 2 |
IC50 = 11 nM
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CP0476929
|
(3R)-1-[2-[4-[6-hydroxy-3-(3-hydroxyphenyl)-4-methyl-2H-chromen-2-yl]phenoxy]ethyl]pyrrolidine-3-carbonitrile
Show/Hide
|
C29H28N2O4
|
1
|
| 1 |
IC50 = 0.8 nM
|
|
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CP0239890
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(E)-3-[4-[(1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-1,3,4,9-tetrahydropyrido[3,4-b]indol-1-yl]phenyl]prop-2-enoic acid
Show/Hide
|
C25H27FN2O2
|
1
|
| 1 |
IC50 = 0.8511 nM
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CP0508370
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(E)-3-[4-[6-hydroxy-1-methyl-2-(4-propan-2-ylphenyl)-3,4-dihydroisoquinolin-1-yl]phenyl]prop-2-enoic acid
Show/Hide
|
C28H29NO3
|
4
|
| 1 |
IC50 = 0.9 nM
|
|
|
| 2 |
IC50 = 1.8 nM
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|
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| 3 |
IC50 = 2.1 nM
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| 4 |
IC50 = 30 nM
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CP0466426
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US10227334, Example 2-(4-((S)-2-(azetidin-1-yl)propoxy)phenyl)-3-(3-hydroxyphenyl)-4-methyl-2H- chromen-6-ol
Show/Hide
|
C28H29NO4
|
1
|
| 1 |
IC50 = 0.9 nM
|
|
|
|
CP0517795
|
US10058534, 54
Show/Hide
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C24H18N4O3S
|
2
|
| 1 |
IC50 = 1 nM
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|
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| 2 |
IC50 = 60 nM
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CP0447043
|
(E)-3-(4-((2-(2-(tert- butyl)phenyl)-6- hydroxybenzo[b] thiophen-3-yl)oxy) phenyl)-acrylic acid
Show/Hide
|
C27H24O4S
|
2
|
| 1 |
IC50 = 1 nM
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|
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| 2 |
IC50 = 36 nM
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|
|
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CP0457843
|
US10058534, 31
Show/Hide
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C26H20F3NO4S
|
2
|
| 1 |
IC50 = 1 nM
|
|
|
| 2 |
IC50 = 10 nM
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CP0458513
|
(E)-3-(4-((2-(4-fluoro- 2-(trifluoromethyl)- phenyl)-6-hydroxy- benzo[b]thiophen-3- yl)oxy)phenyl)acrylic acid
Show/Hide
|
C24H14F4O4S
|
2
|
| 1 |
IC50 = 1 nM
|
|
|
| 2 |
IC50 = 12 nM
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CP0458516
|
(E)-3-(4-((2-(2- ethylphenyl)-6- hydroxybenzo[b] thiophen-3-yl)oxy) phenyl)-acrylic acid
Show/Hide
|
C25H20O4S
|
2
|
| 1 |
IC50 = 1 nM
|
|
|
| 2 |
IC50 = 36 nM
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CP0538802
|
(E)-3-(4-((6-hydroxy-2- (2-(trifluoromethyl)- phenyl)benzo[b] thiophen-3-yl)oxy) phenyl)-acrylic acid
Show/Hide
|
C24H15F3O4S
|
2
|
| 1 |
IC50 = 1 nM
|
|
|
| 2 |
IC50 = 23 nM
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|
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CP0455542
|
(E)-3-[4-[(6S,8R)-7-(2,2-difluoropropyl)-8-methyl-3,6,8,9-tetrahydropyrazolo[4,3-f]isoquinolin-6-yl]-3-methoxyphenyl]prop-2-enoic acid
Show/Hide
|
C24H25F2N3O3
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
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CP0382940
|
(2S)-7-chloro-2-[4-[2-[3-(fluoromethyl)azetidin-1-yl]ethoxy]phenyl]-3-(4-fluorophenyl)-4-methyl-2H-chromen-6-ol
Show/Hide
|
C28H26ClF2NO3
|
1
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| 1 |
IC50 = 1 nM
|
|
|
|
CP0911484
|
6-((6S,8R)-7-(2,2-Difluoroethyl)-6,8-dimethyl-6,7,8,9-tetrahydro-3H-pyrazolo[4,3-f]isoquinolin-6-yl)-N-(1-(3-fluoropropyl)azetidin-3-yl)pyridin-3-amine
Show/Hide
|
C25H31F3N6
|
1
|
| 1 |
IC50 = 1 nM
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|
|
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CP0953372
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N1-(6-((6S,8R)-7-((1-Fluorocyclopropyl)methyl)-8-methyl-6,7,8,9-tetrahydro-3H-pyrazolo[4,3-f]isoquinolin-6-yl)pyridin-3-yl)-N2-(3-fluoropropyl)ethane-1,2-diamine
Show/Hide
|
C25H32F2N6
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
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CP0382938
|
3-(fluoromethyl)-1-[2-[4-[(2S)-4-methyl-3-phenyl-2H-chromen-2-yl]phenoxy]ethyl]azetidine
Show/Hide
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C28H28FNO2
|
1
|
| 1 |
IC50 = 1.1 nM
|
|
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CP0226161
|
(E)-3-[3,5-difluoro-4-[(1S,3R)-6-hydroxy-2-[(2R)-3-methoxy-2-methylpropyl]-3-methyl-3,4-dihydro-1H-isoquinolin-1-yl]phenyl]prop-2-enoic acid
Show/Hide
|
C24H27F2NO4
|
1
|
| 1 |
IC50 = 1.2 nM
|
|
|
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CP0421185
|
(E)-3-[3,5-difluoro-4-[(1R,3R)-2-(2-fluoro-2-methylpropyl)-1,3-dimethyl-4,9-dihydro-3H-pyrido[3,4-b]indol-1-yl]phenyl]prop-2-enoic acid
Show/Hide
|
C26H27F3N2O2
|
1
|
| 1 |
IC50 = 1.259 nM
|
|
|
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CP0078978
|
(E)-3-[4-[(1R)-2-[(2S)-3-fluoro-2-methylpropyl]-6-hydroxy-3,3-dimethyl-1,4-dihydroisoquinolin-1-yl]phenyl]prop-2-enoic acid
Show/Hide
|
C24H28FNO3
|
1
|
| 1 |
IC50 = 1.3 nM
|
|
|
|
CP0403695
|
(E)-3-[4-[(1R,3R)-6-hydroxy-3-methyl-2-(2-methylpropyl)-3,4-dihydro-1H-isoquinolin-1-yl]phenyl]prop-2-enoic acid
Show/Hide
|
C23H27NO3
|
1
|
| 1 |
IC50 = 1.3 nM
|
|
|
|
CP0447305
|
(E)-3-[4-[2-(4-butylphenyl)-6-hydroxy-1-methyl-3,4-dihydroisoquinolin-1-yl]phenyl]prop-2-enoic acid
Show/Hide
|
C29H31NO3
|
2
|
| 1 |
IC50 = 1.4 nM
|
|
|
| 2 |
IC50 = 23 nM
|
|
|
|
CP0474706
|
4-methyl-2-[4-[(2S)-2-[(3R)-3-methylpyrrolidin-1-yl]propoxy]phenyl]-3-(3-methylsulfonylphenyl)-2H-chromen-6-ol
Show/Hide
|
C31H35NO5S
|
1
|
| 1 |
IC50 = 1.4 nM
|
|
|
|
CP0393863
|
4-[6-hydroxy-4-methyl-2-[4-[(2S)-2-[(3R)-3-methylpyrrolidin-1-yl]propoxy]phenyl]-2H-chromen-3-yl]benzonitrile
Show/Hide
|
C31H32N2O3
|
1
|
| 1 |
IC50 = 1.5 nM
|
|
|
|
CP0556780
|
(E)-3-[3,5-difluoro-4-[(1R,12S)-16-(2-fluoro-2-methylpropyl)-3,16-diazatetracyclo[10.3.1.02,10.04,9]hexadeca-2(10),4,6,8,13-pentaen-1-yl]phenyl]prop-2-enoic acid
Show/Hide
|
C27H25F3N2O2
|
1
|
| 1 |
IC50 = 1.585 nM
|
|
|
|
CP0479594
|
(E)-3-[4-[(6R)-8,8-dimethyl-7-(2-methylpropyl)-6,9-dihydro-3H-pyrazolo[4,3-f]isoquinolin-6-yl]phenyl]prop-2-enoic acid
Show/Hide
|
C25H29N3O2
|
1
|
| 1 |
IC50 = 1.585 nM
|
|
|
|
CP0234590
|
(E)-3-[3,5-difluoro-4-[(1S)-6-hydroxy-3,3-dimethyl-2-(2-methylpropyl)-1,4-dihydroisoquinolin-1-yl]phenyl]prop-2-enoic acid
Show/Hide
|
C24H27F2NO3
|
1
|
| 1 |
IC50 = 1.6 nM
|
|
|
|
CP0296034
|
(E)-3-[3,5-difluoro-4-[(1S)-2-[(2S)-3-fluoro-2-methylpropyl]-6-hydroxy-3,3-dimethyl-1,4-dihydroisoquinolin-1-yl]phenyl]prop-2-enoic acid
Show/Hide
|
C24H26F3NO3
|
1
|
| 1 |
IC50 = 1.6 nM
|
|
|
|
CP0391623
|
(1R,12R)-1-[2,6-difluoro-4-[2-[3-(fluoromethyl)azetidin-1-yl]ethoxy]phenyl]-16-(2-fluoro-2-methylpropyl)-3,16-diazatetracyclo[10.3.1.02,10.04,9]hexadeca-2(10),4,6,8-tetraene
Show/Hide
|
C30H35F4N3O
|
1
|
| 1 |
IC50 = 1.995 nM
|
|
|
|
CP0734555
|
(1s,4r)-N-(4-(4-((1r,3r,5R,7S)-adamantan-2-ylidene(4-hydroxyphenyl)methyl)phenoxy)butyl)-4-(trifluoromethyl)cyclohexanecarboxamide
Show/Hide
|
C35H42F3NO3
|
1
|
| 1 |
IC50 = 2 nM
|
|
|
|
CP0762762
|
(3aS,6aS)-N-(4-(4-((1r,3r,5R,7S)-adamantan-2-ylidene(4-hydroxyphenyl)methyl)phenoxy)butyl)octahydro-2,5-methanopentalene-2-carboxamide
Show/Hide
|
C37H45NO3
|
1
|
| 1 |
IC50 = 2 nM
|
|
|
|
CP0361697
|
(E)-3-[4-[(E)-2-[4-chloro-2-(trifluoromethyl)phenyl]-1-(1H-indol-2-yl)but-1-enyl]phenyl]prop-2-enoic acid
Show/Hide
|
C28H21ClF3NO2
|
1
|
| 1 |
IC50 = 2 nM
|
|
|
|
CP0363869
|
(E)-3-[4-[(1R,3R)-3-methyl-2-(2-methylpropyl)-1,3,4,9-tetrahydropyrido[3,4-b]indol-1-yl]phenyl]prop-2-enoic acid
Show/Hide
|
C25H28N2O2
|
1
|
| 1 |
IC50 = 2.089 nM
|
|
|
|
CP0705293
|
(E)-3-(4-(((1r,3r,5R,7S)-Adamantan-2-ylidene)(4-hydroxyphenyl)-methyl)phenyl)-N,N-bis(2-hydroxyethyl)acrylamide
Show/Hide
|
C30H35NO4
|
1
|
| 1 |
IC50 = 2.1 nM
|
|
|
|
CP0535195
|
(2S)-2-[4-[2-[3-(fluoromethyl)azetidin-1-yl]ethoxy]phenyl]-3-(4-fluorophenyl)-4-methyl-2H-chromen-6-amine
Show/Hide
|
C28H28F2N2O2
|
1
|
| 1 |
IC50 = 2.5 nM
|
|
|
|
CP0455543
|
(E)-3-[4-[(6S,8R)-7-(2-fluoro-2-methylpropyl)-6,8-dimethyl-8,9-dihydro-3H-pyrazolo[4,3-f]isoquinolin-6-yl]-3-methoxyphenyl]prop-2-enoic acid
Show/Hide
|
C26H30FN3O3
|
1
|
| 1 |
IC50 = 2.512 nM
|
|
|
|
CP0943929
|
N-(1-(3-fluoropropyl)azetidin-3-yl)-6-((6S,8R)-5-methoxy-8-methyl-7-(2,2,2-trifluoroethyl)-6,7,8,9-tetrahydro-3H-pyrazolo[4,3-f]isoquinolin-6-yl)pyridin-3-amine
Show/Hide
|
C25H30F4N6O
|
1
|
| 1 |
IC50 = 2.512 nM
|
|
|
|
CP0213170
|
(E)-3-[4-[7-hydroxy-3-[2-methyl-4-(trifluoromethoxy)phenyl]-2-oxochromen-4-yl]oxyphenyl]prop-2-enoic acid
Show/Hide
|
C26H17F3O7
|
2
|
| 1 |
IC50 = 2.7 nM
|
|
|
| 2 |
IC50 = 3.9 nM
|
|
|
|
CP0754813
|
(E)-3-(4-(((1r,3r,5R,7S)-Adamantan-2-ylidene)(4-hydroxyphenyl)-methyl)phenyl)-N-(2-(dimethylamino)ethyl)acrylamide
Show/Hide
|
C30H36N2O2
|
1
|
| 1 |
IC50 = 2.9 nM
|
|
|
|
CP0051115
|
2-(4-fluorophenyl)-1-methyl-1-{4-[2-(piperidin-1-yl)ethoxy]phenyl}-1,2,3,4-tetrahydroisoquinolin-6-ol
Show/Hide
|
C29H33FN2O2
|
1
|
| 1 |
IC50 = 3 nM
|
|
|
|
CP0454557
|
(E)-3-[4-[2-(3-fluoro-4-propan-2-ylphenyl)-6-hydroxy-1-methyl-3,4-dihydroisoquinolin-1-yl]phenyl]prop-2-enoic acid
Show/Hide
|
C28H28FNO3
|
2
|
| 1 |
IC50 = 3 nM
|
|
|
| 2 |
IC50 = 108 nM
|
|
|
|
CP0045086
|
4-Hydroxytamoxifen
Show/Hide
|
C26H29NO2
|
2
|
| 1 |
IC50 = 3 nM
|
|
|
| 2 |
IC50 = 10.2 nM
|
|
|
|
CP0519438
|
(E)-2-(4- hydroxyphenyl)-3-(4- (2-(2-methyl-2H- tetrazol-5-yl)vinyl)- phenoxy)benzo[b] thiophen-6-ol
Show/Hide
|
C24H18N4O3S
|
2
|
| 1 |
IC50 = 3 nM
|
|
|
| 2 |
IC50 = 34 nM
|
|
|
|
CP0538812
|
US10058534, 80
Show/Hide
|
C25H20O5S
|
2
|
| 1 |
IC50 = 3 nM
|
|
|
| 2 |
IC50 = 123 nM
|
|
|
|
CP0705276
|
(3r,5r,7r)-N-(3-(4-((1r,3r,5R,7S)-adamantan-2-ylidene(4-hydroxyphenyl)methyl)phenoxy)propyl)adamantane-1-carboxamide
Show/Hide
|
C37H45NO3
|
1
|
| 1 |
IC50 = 3 nM
|
|
|
|
CP0560784
|
1-[2-[4-[(2S)-6-fluoro-3-(4-fluorophenyl)-4-methyl-2H-chromen-2-yl]phenoxy]ethyl]-3-(fluoromethyl)azetidine
Show/Hide
|
C28H26F3NO2
|
1
|
| 1 |
IC50 = 3 nM
|
|
|
|
CP0911949
|
N-(1-(3-Fluoropropyl)-3-methylazetidin-3-yl)-6-((6S,8R)-8-methyl-7-(2,2,2-trifluoroethyl)-6,7,8,9-tetrahydro-3H-pyrazolo[4,3-f]isoquinolin-6-yl)pyridin-3-amine
Show/Hide
|
C25H30F4N6
|
1
|
| 1 |
IC50 = 3.162 nM
|
|
|
|
CP0266681
|
N-butyl-11-[[(7R,8R,9S,13S,14S,17S)-3,17-dihydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-7-yl]sulfanyl]-N-methylundecanamide
Show/Hide
|
C34H55NO3S
|
1
|
| 1 |
IC50 = 3.5 nM
|
|
|
|
CP0234591
|
(E)-3-[4-[(1R)-6-hydroxy-2-(2-methylpropyl)-3,4-dihydro-1H-isoquinolin-1-yl]phenyl]prop-2-enoic acid
Show/Hide
|
C22H25NO3
|
2
|
| 1 |
IC50 = 3.981 nM
|
|
|
| 2 |
IC50 = 4.4 nM
|
|
|
|
CP0519439
|
(E)-3-(4-((2-(4-fluoro- 2-methylphenyl)-6- hydroxybenzo[b] thiophen-3-yl)oxy) phenyl)-acrylic acid
Show/Hide
|
C24H17FO4S
|
2
|
| 1 |
IC50 = 4 nM
|
|
|
| 2 |
IC50 = 78 nM
|
|
|
|
CP0544823
|
(E)-3-(4-((6-hydroxy-2- (o-tolyl)benzo- [b]thiophen-3-yl)oxy)- phenyl)acrylic acid
Show/Hide
|
C24H18O4S
|
2
|
| 1 |
IC50 = 4 nM
|
|
|
| 2 |
IC50 = 89 nM
|
|
|
|
CP0570359
|
(E)-3-[4-[(E)-1-(1H-indol-2-yl)-2-[2-(trifluoromethyl)phenyl]but-1-enyl]phenyl]prop-2-enoic acid
Show/Hide
|
C28H22F3NO2
|
1
|
| 1 |
IC50 = 4 nM
|
|
|
|
CP0458524
|
US10058534, 79
Show/Hide
|
C24H16F2O4S
|
2
|
| 1 |
IC50 = 4.2 nM
|
|
|
| 2 |
IC50 = 52 nM
|
|
|
|
CP0860891
|
(E)-3-(4-(((1r,3r,5R,7S)-Adamantan-2-ylidene)(4-hydroxyphenyl)-methyl)phenyl)-N-(4-hydroxybutyl)acrylamide
Show/Hide
|
C30H35NO3
|
1
|
| 1 |
IC50 = 4.3 nM
|
|
|
|
CP0508461
|
(E)-3-[4-[2-(4-butan-2-ylphenyl)-6-hydroxy-1-methyl-3,4-dihydroisoquinolin-1-yl]phenyl]prop-2-enoic acid
Show/Hide
|
C29H31NO3
|
2
|
| 1 |
IC50 = 4.6 nM
|
|
|
| 2 |
IC50 = 112 nM
|
|
|
|
CP0100791
|
4-[4-(4-hydroxy-3-methylphenyl)heptan-4-yl]-2-methylphenol
Show/Hide
|
C21H28O2
|
1
|
| 1 |
IC50 = 4.9 nM
|
|
|
|
CP0928284
|
6-((6S,8R)-5-fluoro-8-methyl-7-(2,2,2-trifluoroethyl)-6,7,8,9-tetrahydro-3H-pyrazolo[4,3-f]isoquinolin-6-yl)-N-(1-(3-fluoropropyl)azetidin-3-yl)pyridin-3-amine
Show/Hide
|
C24H27F5N6
|
1
|
| 1 |
IC50 = 5.012 nM
|
|
|
|
CP0671639
|
(E)-3-(4-(((1r,3r,5R,7S)-Adamantan-2-ylidene)(4-hydroxyphenyl)-methyl)phenyl)-N-(2-hydroxyethyl)-N-methylacrylamide
Show/Hide
|
C29H33NO3
|
1
|
| 1 |
IC50 = 5.4 nM
|
|
|
|
CP0457841
|
(E)-3-(4-((6-hydroxy-2- (2-methylpyridin-3- yl)benzo[b]thiophen-3- yl)oxy)phenyl)acrylic acid
Show/Hide
|
C23H17NO4S
|
2
|
| 1 |
IC50 = 5.4 nM
|
|
|
| 2 |
IC50 = 669 nM
|
|
|
|
CP0205422
|
(E)-3-[4-[(1R,3R)-6-hydroxy-1,3-dimethyl-2-(2-methylpropyl)-3,4-dihydroisoquinolin-1-yl]phenyl]prop-2-enoic acid
Show/Hide
|
C24H29NO3
|
1
|
| 1 |
IC50 = 5.5 nM
|
|
|
|
CP0447311
|
(E)-3-[4-[6-hydroxy-1-methyl-2-(4-pentylphenyl)-3,4-dihydroisoquinolin-1-yl]phenyl]prop-2-enoic acid
Show/Hide
|
C30H33NO3
|
2
|
| 1 |
IC50 = 5.5 nM
|
|
|
| 2 |
IC50 = 55 nM
|
|
|
|
CP0682150
|
(E)-3-(4-(((1r,3r,5R,7S)-Adamantan-2-ylidene)(4-hydroxyphenyl)-methyl)phenyl)-N-(2-hydroxyethyl)acrylamide
Show/Hide
|
C28H31NO3
|
1
|
| 1 |
IC50 = 5.6 nM
|
|
|
|
CP0466430
|
4-methyl-2-[4-[(2S)-2-[(3R)-3-methylpyrrolidin-1-yl]propoxy]phenyl]-3-(4-methylsulfonylphenyl)-2H-chromen-6-ol
Show/Hide
|
C31H35NO5S
|
1
|
| 1 |
IC50 = 5.7 nM
|
|
|
|
CP0382939
|
(6S)-6-[4-[2-[3-(fluoromethyl)azetidin-1-yl]ethoxy]phenyl]-7-(4-fluorophenyl)-8-methyl-1,6-dihydropyrano[2,3-f]indazole
Show/Hide
|
C29H27F2N3O2
|
1
|
| 1 |
IC50 = 5.7 nM
|
|
|
|
CP0122533
|
(E)-3-[4-[(1R,3R)-6-hydroxy-2-[(2R)-3-methoxy-2-methylpropyl]-3-methyl-3,4-dihydro-1H-isoquinolin-1-yl]phenyl]prop-2-enoic acid
Show/Hide
|
C24H29NO4
|
1
|
| 1 |
IC50 = 5.8 nM
|
|
|
|
CP0481989
|
(S,E)-3-(4-((6-hydroxy- 2-(2-(1- hydroxyethyl)phenyl) benzo[b]thiophen-3- yl)oxy)phenyl)acrylic acid
Show/Hide
|
C25H20O5S
|
2
|
| 1 |
IC50 = 6 nM
|
|
|
| 2 |
IC50 = 179 nM
|
|
|
|
CP0550519
|
(E)-3-[4-[(E)-2-[2-chloro-4-(trifluoromethyl)phenyl]-1-(1H-indol-2-yl)but-1-enyl]phenyl]prop-2-enoic acid
Show/Hide
|
C28H21ClF3NO2
|
1
|
| 1 |
IC50 = 6 nM
|
|
|
|
CP0148109
|
(E)-3-[4-[(1R,3R)-6-hydroxy-3-methyl-2-[4-(trifluoromethoxy)phenyl]-3,4-dihydro-1H-isoquinolin-1-yl]phenyl]prop-2-enoic acid
Show/Hide
|
C26H22F3NO4
|
1
|
| 1 |
IC50 = 6.1 nM
|
|
|
|
CP0446732
|
(E)-3-[4-[(6S,8R)-7-(2,2-difluoropropyl)-8-methyl-3,6,8,9-tetrahydropyrazolo[4,3-f]isoquinolin-6-yl]-2-fluoro-3-methoxyphenyl]prop-2-enoic acid
Show/Hide
|
C24H24F3N3O3
|
1
|
| 1 |
IC50 = 6.31 nM
|
|
|
|
CP0484747
|
(E)-3-[4-[(6R)-7-(2-methylpropyl)-3,6,8,9-tetrahydropyrazolo[4,3-f]isoquinolin-6-yl]phenyl]prop-2-enoic acid
Show/Hide
|
C23H25N3O2
|
1
|
| 1 |
IC50 = 6.31 nM
|
|
|
|
CP0198191
|
(E)-3-[4-[(1R)-2-(2-fluoro-2-methylpropyl)-6-hydroxy-3,3-dimethyl-1,4-dihydroisoquinolin-1-yl]phenyl]prop-2-enoic acid
Show/Hide
|
C24H28FNO3
|
1
|
| 1 |
IC50 = 6.5 nM
|
|
|
|
CP0243826
|
(E)-3-[4-[[7-hydroxy-3-[2-methyl-4-(trifluoromethoxy)phenyl]-2-oxochromen-4-yl]methyl]phenyl]prop-2-enoic acid
Show/Hide
|
C27H19F3O6
|
1
|
| 1 |
IC50 = 7 nM
|
|
|
|
CP0205421
|
(E)-3-[4-[(1R)-6-hydroxy-3,3-dimethyl-2-(2-methylpropyl)-1,4-dihydroisoquinolin-1-yl]phenyl]prop-2-enoic acid
Show/Hide
|
C24H29NO3
|
1
|
| 1 |
IC50 = 7 nM
|
|
|
|
CP0447307
|
(E)-3-[4-[2-(4-fluorophenyl)-6-hydroxy-1-methyl-3,4-dihydroisoquinolin-1-yl]phenyl]prop-2-enoic acid
Show/Hide
|
C25H22FNO3
|
2
|
| 1 |
IC50 = 7 nM
|
|
|
| 2 |
IC50 = 202 nM
|
|
|
|
CP0466126
|
(E)-3-[4-[(E)-2-(2,4-dichlorophenyl)-1-(1H-indol-2-yl)but-1-enyl]phenyl]prop-2-enoic acid
Show/Hide
|
C27H21Cl2NO2
|
1
|
| 1 |
IC50 = 9 nM
|
|
|
|
CP0550610
|
(E)-3-[4-[(E)-1-(1H-indol-2-yl)-2-(2-methylphenyl)but-1-enyl]phenyl]prop-2-enoic acid
Show/Hide
|
C28H25NO2
|
1
|
| 1 |
IC50 = 9 nM
|
|
|
|
CP0562925
|
(E)-3-[4-[(E)-2-(2-cyanophenyl)-1-(1H-indol-2-yl)but-1-enyl]phenyl]prop-2-enoic acid
Show/Hide
|
C28H22N2O2
|
1
|
| 1 |
IC50 = 9 nM
|
|
|
|
CP0671624
|
(E)-3-(4-(((1r,3r,5R,7S)-Adamantan-2-ylidene)(4-hydroxyphenyl)-methyl)phenyl)-N-butylacrylamide
Show/Hide
|
C30H35NO2
|
1
|
| 1 |
IC50 = 9.1 nM
|
|
|
|
CP0435375
|
(2R)-3-(3-hydroxyphenyl)-4-methyl-2-[4-[(2S)-2-[(3R)-3-methylpyrrolidin-1-yl]propoxy]phenyl]-2H-chromen-6-ol
Show/Hide
|
C30H33NO4
|
1
|
| 1 |
IC50 = 9.7 nM
|
|
|
|
CP0176106
|
(E)-3-[3,5-difluoro-4-[(1S)-6-hydroxy-2-[(2R)-3-methoxy-2-methylpropyl]-3,3-dimethyl-1,4-dihydroisoquinolin-1-yl]phenyl]prop-2-enoic acid
Show/Hide
|
C25H29F2NO4
|
1
|
| 1 |
IC50 = 9.9 nM
|
|
|
|
CP0264844
|
(R)-8-Methoxy-5-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-11,12-dihydro-5H-6,13-dioxa-benzo[3,4]cyclohepta[1,2-a]naphthalen-2-ol
Show/Hide
|
C31H33NO5
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0307562
|
(R)-5-[4-(2-Piperidin-1-yl-ethoxy)-phenyl]-11,12-dihydro-5H-6,13-dioxa-benzo[3,4]cyclohepta[1,2-a]naphthalen-8-ol
Show/Hide
|
C30H31NO4
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0667871
|
(E)-3-(4-(((1r,3r,5R,7S)-Adamantan-2-ylidene)(4-hydroxyphenyl)-methyl)phenyl)-N-(5-hydroxypentyl)acrylamide
Show/Hide
|
C31H37NO3
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0682149
|
(E)-3-(4-(((1r,3r,5R,7S)-Adamantan-2-ylidene)(4-hydroxyphenyl)-methyl)phenyl)-N-(2-aminoethyl)acrylamide
Show/Hide
|
C28H32N2O2
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0150847
|
(R)-5-[4-(2-Piperidin-1-yl-ethoxy)-phenyl]-11,12-dihydro-5H-6,13-dioxa-benzo[3,4]cyclohepta[1,2-a]naphthalene-2,8-diol
Show/Hide
|
C30H31NO5
|
1
|
| 1 |
IC50 = 11 nM
|
|
|
|
CP0198193
|
(E)-3-[4-[(1R)-6-hydroxy-1-methyl-2-(2-methylpropyl)-3,4-dihydroisoquinolin-1-yl]phenyl]prop-2-enoic acid
Show/Hide
|
C23H27NO3
|
1
|
| 1 |
IC50 = 11 nM
|
|
|
|
CP0481919
|
US10058534, 72
Show/Hide
|
C25H18N2O3S
|
2
|
| 1 |
IC50 = 11 nM
|
|
|
| 2 |
IC50 = 53 nM
|
|
|
|
CP0534385
|
(2R)-2-[4-[(2S)-2-[(3R)-3-(fluoromethyl)pyrrolidin-1-yl]propoxy]phenyl]-3-(3-hydroxyphenyl)-4-methyl-2H-chromen-6-ol
Show/Hide
|
C30H32FNO4
|
1
|
| 1 |
IC50 = 11 nM
|
|
|
|
CP0447310
|
(E)-3-[4-[6-hydroxy-1-methyl-2-(3-propan-2-ylphenyl)-3,4-dihydroisoquinolin-1-yl]phenyl]prop-2-enoic acid
Show/Hide
|
C28H29NO3
|
2
|
| 1 |
IC50 = 12 nM
|
|
|
| 2 |
IC50 = 466 nM
|
|
|
|
CP0682145
|
(E)-3-(4-(((1r,3r,5R,7S)-Adamantan-2-ylidene)(4-hydroxyphenyl)-methyl)phenyl)-N-(3-aminopropyl)acrylamide
Show/Hide
|
C29H34N2O2
|
1
|
| 1 |
IC50 = 12 nM
|
|
|
|
CP0484805
|
(R)-2-(4-(2-(3-(Fluoromethyl)azetidin-1-yl)ethoxy)phenyl)-3-(3-hydroxyphenyl)-4-methyl-2H-chromen-6-ol
Show/Hide
|
C28H28FNO4
|
1
|
| 1 |
IC50 = 13 nM
|
|
|
|
CP0428770
|
(E)-3-[4-[2-(3-fluoro-4-methylphenyl)-6-hydroxy-1-methyl-3,4-dihydroisoquinolin-1-yl]phenyl]prop-2-enoic acid
Show/Hide
|
C26H24FNO3
|
2
|
| 1 |
IC50 = 15 nM
|
|
|
| 2 |
IC50 = 111 nM
|
|
|
|
CP0448666
|
(E)-3-[4-[6-hydroxy-1-methyl-2-(6-propan-2-ylpyridin-3-yl)-3,4-dihydroisoquinolin-1-yl]phenyl]prop-2-enoic acid
Show/Hide
|
C27H28N2O3
|
2
|
| 1 |
IC50 = 15 nM
|
|
|
| 2 |
IC50 = 1158 nM
|
|
|
|
CP0470346
|
(2R)-2-[4-[2-[3-(fluoromethyl)azetidin-1-yl]ethoxy]phenyl]-3-(4-fluorophenyl)-4-methyl-2H-chromen-6-ol
Show/Hide
|
C28H27F2NO3
|
1
|
| 1 |
IC50 = 15 nM
|
|
|
|
CP0550944
|
3-(fluoromethyl)-1-[2-[4-[(2S)-3-(4-fluorophenyl)-6-methoxy-4-methyl-2H-chromen-2-yl]phenoxy]ethyl]azetidine
Show/Hide
|
C29H29F2NO3
|
1
|
| 1 |
IC50 = 15 nM
|
|
|
|
CP0076787
|
(E)-3-[3,5-difluoro-4-[(1R,12R)-16-(2-fluoro-2-methylpropyl)-3,16-diazatetracyclo[10.3.1.02,10.04,9]hexadeca-2(10),4,6,8-tetraen-1-yl]phenyl]prop-2-enoic acid
Show/Hide
|
C27H27F3N2O2
|
1
|
| 1 |
IC50 = 15.85 nM
|
|
|
|
CP0860031
|
(E)-3-(4-(((1r,3r,5R,7S)-Adamantan-2-ylidene)(4-hydroxyphenyl)methyl)phenyl)acrylic acid
Show/Hide
|
C26H26O3
|
2
|
| 1 |
IC50 = 17 nM
|
|
|
| 2 |
IC50 = 500 nM
|
|
|
|
CP0458523
|
US10058534, 73
Show/Hide
|
C26H20N2O3S
|
2
|
| 1 |
IC50 = 17 nM
|
|
|
| 2 |
IC50 = 125 nM
|
|
|
|
CP0557133
|
(E)-3-[4-[(E)-2-(4-chloro-2-cyanophenyl)-1-(1H-indol-2-yl)but-1-enyl]phenyl]prop-2-enoic acid
Show/Hide
|
C28H21ClN2O2
|
1
|
| 1 |
IC50 = 18 nM
|
|
|
|
CP0259625
|
(E)-3-[4-[3-(4-fluoro-2-methylphenyl)-7-hydroxy-2-oxochromen-4-yl]oxyphenyl]prop-2-enoic acid
Show/Hide
|
C25H17FO6
|
2
|
| 1 |
IC50 = 21 nM
|
|
|
| 2 |
IC50 = 27 nM
|
|
|
|
CP0568410
|
(E)-3-[4-[(E)-2-(2-chloro-4-fluorophenyl)-1-(1H-indol-2-yl)but-1-enyl]phenyl]prop-2-enoic acid
Show/Hide
|
C27H21ClFNO2
|
1
|
| 1 |
IC50 = 21 nM
|
|
|
|
CP0466184
|
(E)-3-[4-[(E)-2-(2,5-dichlorophenyl)-1-(1H-indol-2-yl)but-1-enyl]phenyl]prop-2-enoic acid
Show/Hide
|
C27H21Cl2NO2
|
1
|
| 1 |
IC50 = 25 nM
|
|
|
|
CP0457840
|
(E)-3-(4-((6-hydroxy-2- phenylbenzo[b]thiophen- 3-yl)oxy)phenyl)- acrylic acid
Show/Hide
|
C23H16O4S
|
2
|
| 1 |
IC50 = 26 nM
|
|
|
| 2 |
IC50 = 2306 nM
|
|
|
|
CP0473578
|
US10058534, 2
Show/Hide
|
C23H16O5S
|
2
|
| 1 |
IC50 = 26 nM
|
|
|
| 2 |
IC50 = 748 nM
|
|
|
|
CP0448669
|
(E)-3-[4-[(1S)-6-hydroxy-1-methyl-2-(4-propan-2-ylphenyl)-3,4-dihydroisoquinolin-1-yl]phenyl]prop-2-enoic acid
Show/Hide
|
C28H29NO3
|
1
|
| 1 |
IC50 = 27 nM
|
|
|
|
CP0434260
|
(7S)-7-[4-[2-[3-(fluoromethyl)azetidin-1-yl]ethoxy]phenyl]-6-(4-fluorophenyl)-5-methyl-1,7-dihydropyrano[3,2-f]indazole
Show/Hide
|
C29H27F2N3O2
|
1
|
| 1 |
IC50 = 27 nM
|
|
|
|
CP0573121
|
(E)-3-[4-[(E)-2-(2-chlorophenyl)-1-(1H-indol-2-yl)but-1-enyl]phenyl]prop-2-enoic acid
Show/Hide
|
C27H22ClNO2
|
1
|
| 1 |
IC50 = 29 nM
|
|
|
|
CP0172562
|
(E)-3-[4-[[3-(4-chloro-2-methylphenyl)-7-hydroxy-2-oxochromen-4-yl]methyl]phenyl]prop-2-enoic acid
Show/Hide
|
C26H19ClO5
|
1
|
| 1 |
IC50 = 30 nM
|
|
|
|
CP0550517
|
(E)-3-[4-[(E)-1-(1H-indol-2-yl)-2-(4-methoxyphenyl)but-1-enyl]phenyl]prop-2-enoic acid
Show/Hide
|
C28H25NO3
|
1
|
| 1 |
IC50 = 30 nM
|
|
|
|
CP0188527
|
(2S)-3-[(1R,3R)-1-(4-chlorophenyl)-3-methyl-1,3,4,9-tetrahydropyrido[3,4-b]indol-2-yl]-2-methylpropanoic acid
Show/Hide
|
C22H23ClN2O2
|
1
|
| 1 |
IC50 = 30.2 nM
|
|
|
|
CP0458521
|
US10058534, 1
Show/Hide
|
C23H18O5S
|
2
|
| 1 |
IC50 = 31 nM
|
|
|
| 2 |
IC50 = 457 nM
|
|
|
|
CP0219221
|
(E)-3-[4-[(E)-2-(2-chloro-4-cyanophenyl)-1-(1H-indol-2-yl)but-1-enyl]phenyl]prop-2-enoic acid
Show/Hide
|
C28H21ClN2O2
|
1
|
| 1 |
IC50 = 31 nM
|
|
|
|
CP0448668
|
(E)-3-[4-[(1R)-6-hydroxy-1-methyl-2-(4-propan-2-ylphenyl)-3,4-dihydroisoquinolin-1-yl]phenyl]prop-2-enoic acid
Show/Hide
|
C28H29NO3
|
1
|
| 1 |
IC50 = 34 nM
|
|
|
|
CP0505212
|
(E)-3-[4-[6-hydroxy-2-[4-(trifluoromethoxy)phenyl]-3,4-dihydro-1H-isoquinolin-1-yl]phenyl]prop-2-enoic acid
Show/Hide
|
C25H20F3NO4
|
1
|
| 1 |
IC50 = 35 nM
|
|
|
|
CP0447302
|
(E)-3-[4-(6-hydroxy-1-methyl-2-phenyl-3,4-dihydroisoquinolin-1-yl)phenyl]prop-2-enoic acid
Show/Hide
|
C25H23NO3
|
2
|
| 1 |
IC50 = 35 nM
|
|
|
| 2 |
IC50 = 366 nM
|
|
|
|
CP0476241
|
US9714221, Example 25
Show/Hide
|
C30H37FN2O2
|
1
|
| 1 |
IC50 = 38 nM
|
|
|
|
CP0477705
|
(E)-3-(4-((6-hydroxy-2- (4-hydroxyphenyl)- benzo[b]thiophen-3- yl)oxy)phenyl)acrylamide
Show/Hide
|
C23H17NO4S
|
1
|
| 1 |
IC50 = 40 nM
|
|
|
|
CP0455588
|
(E)-3-[4-[(1S)-6-hydroxy-2-(2-methylpropyl)-3,4-dihydro-1H-isoquinolin-1-yl]phenyl]prop-2-enoic acid
Show/Hide
|
C22H25NO3
|
1
|
| 1 |
IC50 = 42 nM
|
|
|
|
CP0553936
|
(E)-3-[4-[(E)-2-(2-chloro-6-methylphenyl)-1-(1H-indol-2-yl)but-1-enyl]phenyl]prop-2-enoic acid
Show/Hide
|
C28H24ClNO2
|
1
|
| 1 |
IC50 = 42 nM
|
|
|
|
CP0111178
|
(E)-3-[4-[(1R)-6-hydroxy-7-methyl-2-(2-methylpropyl)-3,4-dihydro-1H-isoquinolin-1-yl]phenyl]prop-2-enoic acid
Show/Hide
|
C23H27NO3
|
1
|
| 1 |
IC50 = 43 nM
|
|
|
|
CP0447303
|
2-(4-fluorophenyl)-1-[4-[(E)-2-[5-(hydroxymethyl)-1,3,4-oxadiazol-2-yl]ethenyl]phenyl]-1-methyl-3,4-dihydroisoquinolin-6-ol
Show/Hide
|
C27H24FN3O3
|
1
|
| 1 |
IC50 = 43 nM
|
|
|
|
CP0251826
|
(1R,3R)-1-(4-chlorophenyl)-2-(2-hydroxyethyl)-3-methyl-1,3,4,9-tetrahydropyrido[3,4-b]indol-6-ol
Show/Hide
|
C20H21ClN2O2
|
1
|
| 1 |
IC50 = 43.65 nM
|
|
|
|
CP0109093
|
(E)-3-[4-[(1R,3R)-2-[(2R)-3-hydroxy-2-methylpropyl]-3-methyl-1,3,4,9-tetrahydropyrido[3,4-b]indol-1-yl]phenyl]prop-2-enoic acid
Show/Hide
|
C25H28N2O3
|
1
|
| 1 |
IC50 = 45.71 nM
|
|
|
|
CP0428769
|
(E)-3-[4-[2-(4-fluorophenyl)-6-hydroxy-1-methyl-3,4-dihydroisoquinolin-1-yl]phenyl]-N-(3,3,3-trifluoropropyl)prop-2-enamide
Show/Hide
|
C28H26F4N2O2
|
1
|
| 1 |
IC50 = 46 nM
|
|
|
|
CP0109094
|
(E)-3-[4-[(1R,3R)-2-[(2S)-3-hydroxy-2-methylpropyl]-3-methyl-1,3,4,9-tetrahydropyrido[3,4-b]indol-1-yl]phenyl]prop-2-enoic acid
Show/Hide
|
C25H28N2O3
|
1
|
| 1 |
IC50 = 46.77 nM
|
|
|
|
CP0219220
|
(E)-3-[4-[(E)-2-(2-cyano-3-fluorophenyl)-1-(1H-indol-2-yl)but-1-enyl]phenyl]prop-2-enoic acid
Show/Hide
|
C28H21FN2O2
|
1
|
| 1 |
IC50 = 49 nM
|
|
|
|
CP0246740
|
(E)-3-[4-[[7-hydroxy-2-oxo-3-[4-(trifluoromethoxy)phenyl]chromen-4-yl]methyl]phenyl]prop-2-enoic acid
Show/Hide
|
C26H17F3O6
|
1
|
| 1 |
IC50 = 52 nM
|
|
|
|
CP0481918
|
(E)-3-(4-((6-hydroxy-2- (4- hydroxyphenyl)benzo[b] thiophen-3- yl)oxy)phenyl)-N- methylacrylamide
Show/Hide
|
C24H19NO4S
|
2
|
| 1 |
IC50 = 53 nM
|
|
|
| 2 |
IC50 = 58 nM
|
|
|
|
CP0172564
|
(E)-3-[4-[[5-fluoro-3-(4-fluoro-2-methylphenyl)-7-hydroxy-2-oxochromen-4-yl]methyl]phenyl]prop-2-enoic acid
Show/Hide
|
C26H18F2O5
|
1
|
| 1 |
IC50 = 55 nM
|
|
|
|
CP0558590
|
2-(4-fluorophenyl)-1-[4-[(E)-2-(1H-imidazol-5-yl)ethenyl]phenyl]-1-methyl-3,4-dihydroisoquinolin-6-ol
Show/Hide
|
C27H24FN3O
|
1
|
| 1 |
IC50 = 55 nM
|
|
|
|
CP0458522
|
(E)-3-(4-((6-hydroxy-2- (4- hydroxyphenyl)benzo[b] thiophen-3- yl)oxy)phenyl)-N-(2- hydroxyethyl)acrylamide
Show/Hide
|
C25H21NO5S
|
1
|
| 1 |
IC50 = 55 nM
|
|
|
|
CP0539052
|
2-(4-fluorophenyl)-1-methyl-1-[4-[(E)-2-(5-propyl-1,3,4-oxadiazol-2-yl)ethenyl]phenyl]-3,4-dihydroisoquinolin-6-ol
Show/Hide
|
C29H28FN3O2
|
1
|
| 1 |
IC50 = 56 nM
|
|
|
|
CP0448665
|
2-(4-fluorophenyl)-1-methyl-1-[4-[(E)-2-(3-methylimidazol-4-yl)ethenyl]phenyl]-3,4-dihydroisoquinolin-6-ol
Show/Hide
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C28H26FN3O
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1
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| 1 |
IC50 = 57 nM
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CP0172563
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(E)-3-[4-[[3-(4-fluoro-2-methylphenyl)-7-hydroxy-2-oxochromen-4-yl]-methylamino]phenyl]prop-2-enoic acid
Show/Hide
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C26H20FNO5
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1
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| 1 |
IC50 = 60 nM
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CP0446734
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(E)-3-[4-[7-(2-methylpropyl)-3,6,8,9-tetrahydropyrrolo[3,2-f]isoquinolin-6-yl]phenyl]prop-2-enoic acid
Show/Hide
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C24H26N2O2
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1
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| 1 |
IC50 = 63.1 nM
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CP0546672
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4-[[(2-chloro-5-phenylthieno[2,3-d]pyrimidin-4-yl)amino]methyl]phenol
Show/Hide
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C19H14ClN3OS
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1
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| 1 |
IC50 = 65 nM
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CP0466124
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(E)-3-[4-[(E)-1-(1H-indol-2-yl)-2-phenylbut-1-enyl]phenyl]prop-2-enoic acid
Show/Hide
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C27H23NO2
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1
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| 1 |
IC50 = 66.6 nM
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CP0553324
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(E)-3-[4-[(E)-1-(1H-indol-2-yl)-2-[3-(trifluoromethoxy)phenyl]but-1-enyl]phenyl]prop-2-enoic acid
Show/Hide
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C28H22F3NO3
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1
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| 1 |
IC50 = 68 nM
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CP0562824
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(E)-3-[4-[(E)-1-(1H-indol-2-yl)-2-(3-methylphenyl)but-1-enyl]phenyl]prop-2-enoic acid
Show/Hide
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C28H25NO2
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1
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| 1 |
IC50 = 69 nM
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CP0444035
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(E)-3-[4-(6-hydroxy-2-phenyl-3,4-dihydro-1H-isoquinolin-1-yl)phenyl]prop-2-enoic acid
Show/Hide
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C24H21NO3
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1
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| 1 |
IC50 = 71 nM
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CP0564672
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(2S)-2-[4-[2-[3-(fluoromethyl)azetidin-1-yl]ethoxy]phenyl]-4-methyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-2H-chromen-6-ol
Show/Hide
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C27H31FN2O3
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1
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| 1 |
IC50 = 72 nM
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CP0465131
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(E)-3-[4-[(1R)-1-(difluoromethyl)-6-hydroxy-2-(4-propan-2-ylphenyl)-3,4-dihydroisoquinolin-1-yl]phenyl]prop-2-enoic acid
Show/Hide
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C28H27F2NO3
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1
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| 1 |
IC50 = 77 nM
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CP0176107
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(E)-3-[4-[(1R,3R)-3-methyl-2-(2-methylpropyl)-3,4-dihydro-1H-isoquinolin-1-yl]phenyl]prop-2-enoic acid
Show/Hide
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C23H27NO2
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1
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| 1 |
IC50 = 82 nM
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CP0109095
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2-[(1R,3R)-1-(4-chlorophenyl)-3-methyl-1,3,4,9-tetrahydropyrido[3,4-b]indol-2-yl]ethanol
Show/Hide
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C20H21ClN2O
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1
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| 1 |
IC50 = 85.11 nM
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CP0474195
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(E)-3-[4-(2-benzyl-6-hydroxy-3,4-dihydro-1H-isoquinolin-1-yl)phenyl]prop-2-enoic acid
Show/Hide
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C25H23NO3
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1
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| 1 |
IC50 = 90 nM
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CP0466125
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(E)-3-[4-[(E)-1-(1H-indol-2-yl)-2-[2-(trifluoromethoxy)phenyl]but-1-enyl]phenyl]prop-2-enoic acid
Show/Hide
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C28H22F3NO3
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1
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| 1 |
IC50 = 93 nM
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CP0213173
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(E)-3-[4-[3-[2-methyl-4-(trifluoromethoxy)phenyl]-2-oxochromen-4-yl]oxyphenyl]prop-2-enoic acid
Show/Hide
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C26H17F3O6
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3
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| 1 |
IC50 = 100 nM
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| 2 |
IC50 = 180 nM
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| 3 |
IC50 > 3100 nM
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CP0560785
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4-[(2S)-2-[4-[2-[3-(fluoromethyl)azetidin-1-yl]ethoxy]phenyl]-4-methyl-3-phenyl-2H-chromen-6-yl]morpholine
Show/Hide
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C32H35FN2O3
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1
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| 1 |
IC50 = 100 nM
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CP0561512
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(E)-3-[4-[1-(difluoromethyl)-6-hydroxy-2-(4-propan-2-ylphenyl)-3,4-dihydroisoquinolin-1-yl]phenyl]prop-2-enoic acid
Show/Hide
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C28H27F2NO3
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1
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| 1 |
IC50 = 110 nM
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CP0393914
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2-(4-fluorophenyl)-1-methyl-1-[4-[(E)-2-(5-methyl-1,3,4-oxadiazol-2-yl)ethenyl]phenyl]-3,4-dihydroisoquinolin-6-ol
Show/Hide
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C27H24FN3O2
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1
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| 1 |
IC50 = 113 nM
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CP0447304
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2-(4-fluorophenyl)-1-methyl-1-[4-[(E)-2-(2-methyltetrazol-5-yl)ethenyl]phenyl]-3,4-dihydroisoquinolin-6-ol
Show/Hide
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C26H24FN5O
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1
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| 1 |
IC50 = 113 nM
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CP0302559
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(E)-3-[4-[[3-(4-fluoro-2-methylphenyl)-7-hydroxy-2-oxochromen-4-yl]methyl]phenyl]prop-2-enoic acid
Show/Hide
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C26H19FO5
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1
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| 1 |
IC50 = 117 nM
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CP0574573
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(E)-3-[4-[6-hydroxy-1-methyl-2-[4-(trifluoromethyl)phenyl]-3,4-dihydroisoquinolin-1-yl]phenyl]prop-2-enoic acid
Show/Hide
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C26H22F3NO3
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1
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| 1 |
IC50 = 119 nM
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CP0574574
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(E)-3-[4-[2-(4-fluorophenyl)-6-hydroxy-1-methyl-3,4-dihydroisoquinolin-1-yl]phenyl]-N-methylprop-2-enamide
Show/Hide
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C26H25FN2O2
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1
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| 1 |
IC50 = 120 nM
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CP0476180
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(E)-3-(4-((2-(2- (dimethylamino)phenyl)- 6-hydroxybenzo[b] thiophen-3- yl)oxy)phenyl)acrylic acid
Show/Hide
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C25H21NO4S
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1
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| 1 |
IC50 = 124 nM
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CP0428768
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(E)-3-[4-[(1R)-6-hydroxy-2-(4-propan-2-ylphenyl)-1-(trifluoromethyl)-3,4-dihydroisoquinolin-1-yl]phenyl]prop-2-enoic acid
Show/Hide
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C28H26F3NO3
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1
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| 1 |
IC50 = 125 nM
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CP0942945
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(6S,8R)-6-(5-((1-(3-fluoropropyl)azetidin-3-yl)amino)pyridin-2-yl)-8-methyl-7-(2,2,2-trifluoroethyl)-6,7,8,9-tetrahydro-3H-pyrazolo[4,3-f]isoquinolin-5-ol
Show/Hide
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C24H28F4N6O
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1
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| 1 |
IC50 = 125.89 nM
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CP0550611
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(E)-3-[4-[(E)-1-(1H-indol-2-yl)-2-[3-(trifluoromethyl)phenyl]but-1-enyl]phenyl]prop-2-enoic acid
Show/Hide
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C28H22F3NO2
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1
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| 1 |
IC50 = 131 nM
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CP0393915
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(E)-3-[4-[6-hydroxy-2-(4-propan-2-ylphenyl)-1-(trifluoromethyl)-3,4-dihydroisoquinolin-1-yl]phenyl]prop-2-enoic acid
Show/Hide
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C28H26F3NO3
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1
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| 1 |
IC50 = 139 nM
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CP0074206
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(R)-5-[4-(2-Pyrrolidin-1-yl-ethoxy)-phenyl]-11,12-dihydro-5H-6,13-dioxa-benzo[3,4]cyclohepta[1,2-a]naphthalene-2,8-diol
Show/Hide
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C29H29NO5
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1
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| 1 |
IC50 = 150 nM
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CP0264843
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(S)-5-[4-(2-Piperidin-1-yl-ethoxy)-phenyl]-11,12-dihydro-5H-6,13-dioxa-benzo[3,4]cyclohepta[1,2-a]naphthalen-8-ol
Show/Hide
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C30H31NO4
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1
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| 1 |
IC50 = 150 nM
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CP0307559
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(S)-8-Methoxy-5-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-11,12-dihydro-5H-6,13-dioxa-benzo[3,4]cyclohepta[1,2-a]naphthalen-2-ol
Show/Hide
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C31H33NO5
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1
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| 1 |
IC50 = 150 nM
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CP0520487
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(E)-3-[4-[(1R,3R)-6-methoxy-3-methyl-2-(2-methylpropyl)-3,4-dihydro-1H-isoquinolin-1-yl]phenyl]prop-2-enoic acid
Show/Hide
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C24H29NO3
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1
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| 1 |
IC50 = 160 nM
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CP0562926
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(E)-3-[4-[(E)-1-(1H-indol-2-yl)-2-[4-(trifluoromethyl)phenyl]but-1-enyl]phenyl]prop-2-enoic acid
Show/Hide
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C28H22F3NO2
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1
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| 1 |
IC50 = 163 nM
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CP0296035
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(E)-3-[4-[(1R)-6-hydroxy-5-methyl-2-(2-methylpropyl)-3,4-dihydro-1H-isoquinolin-1-yl]phenyl]prop-2-enoic acid
Show/Hide
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C23H27NO3
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1
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| 1 |
IC50 = 170 nM
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CP0149126
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(S)-5-[4-(2-Piperidin-1-yl-ethoxy)-phenyl]-11,12-dihydro-5H-6,13-dioxa-benzo[3,4]cyclohepta[1,2-a]naphthalene-2,8-diol
Show/Hide
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C30H31NO5
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1
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| 1 |
IC50 = 174 nM
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CP0569684
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(E)-3-[4-[[3-(2-chloro-4-fluorophenyl)-7-hydroxy-2-oxochromen-4-yl]methyl]phenyl]prop-2-enoic acid
Show/Hide
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C25H16ClFO5
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1
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| 1 |
IC50 = 178 nM
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CP0508371
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(E)-3-[4-[6-hydroxy-1-methyl-2-(4-methylphenyl)-3,4-dihydroisoquinolin-1-yl]phenyl]prop-2-enoic acid
Show/Hide
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C26H25NO3
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1
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| 1 |
IC50 = 207 nM
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CP0534789
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(E)-2-(4-((6-hydroxy-2- (4- hydroxyphenyl)benzo [b]thiophen-3- yl)oxy)benzylidene) butanoic acid
Show/Hide
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C25H20O5S
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1
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| 1 |
IC50 = 216 nM
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CP0204168
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(R)-5-[4-(2-Azepan-1-yl-ethoxy)-phenyl]-11,12-dihydro-5H-6,13-dioxa-benzo[3,4]cyclohepta[1,2-a]naphthalene-2,8-diol
Show/Hide
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C31H33NO5
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1
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| 1 |
IC50 = 217 nM
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CP0465150
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3-[4-[2-(4-fluorophenyl)-6-hydroxy-1-methyl-3,4-dihydroisoquinolin-1-yl]phenyl]propanoic acid
Show/Hide
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C25H24FNO3
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1
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| 1 |
IC50 = 219 nM
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CP0481988
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2-(4-hydroxyphenyl)-3-[4-[(E)-2-(2H-tetrazol-5-yl)ethenyl]phenoxy]-1-benzothiophen-6-ol
Show/Hide
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C23H16N4O3S
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1
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| 1 |
IC50 = 219 nM
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CP0165902
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5R-(+)-[4-(2-diisopropylaminoethoxy)phenyl]-11,12-dihydro-5H-6,13-dioxabenzo[3,4]cyclohepta[1,2-a]naphthalene-2,8-diol
Show/Hide
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C31H35NO5
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1
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| 1 |
IC50 = 220 nM
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CP0041761
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2-(4-hydroxyphenyl)-3-({4-[2-(piperidin-1-yl)ethoxy]phenyl}carbonyl)-1-benzothiophen-6-ol
Show/Hide
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C28H27NO4S
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2
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| 1 |
IC50 = 222 nM
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| 2 |
IC50 > 100 nM
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CP0213171
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(E)-3-[4-[3-(4-fluoro-2-methylphenyl)-2-oxochromen-4-yl]oxyphenyl]prop-2-enoic acid
Show/Hide
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C25H17FO5
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3
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| 1 |
IC50 = 248 nM
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| 2 |
IC50 = 330 nM
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| 3 |
IC50 > 3100 nM
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CP0494869
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(E)-3-[4-[7-ethoxy-3-[2-methyl-4-(trifluoromethoxy)phenyl]-2-oxochromen-4-yl]oxyphenyl]prop-2-enoic acid
Show/Hide
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C28H21F3O7
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1
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| 1 |
IC50 = 253 nM
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CP0555865
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(E)-3-[4-[3-(4-fluoro-2-methylphenyl)-7-hydroxy-2-oxochromen-4-yl]phenyl]prop-2-enoic acid
Show/Hide
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C25H17FO5
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1
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| 1 |
IC50 = 256 nM
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CP0447312
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(E)-3-[4-[2-(2-fluoro-4-propan-2-ylphenyl)-6-hydroxy-1-methyl-3,4-dihydroisoquinolin-1-yl]phenyl]prop-2-enoic acid
Show/Hide
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C28H28FNO3
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2
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| 1 |
IC50 = 262 nM
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| 2 |
IC50 = 374 nM
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CP0219219
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(E)-3-[4-[(E)-2-(4-chlorophenyl)-1-(1H-indol-2-yl)but-1-enyl]phenyl]prop-2-enoic acid
Show/Hide
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C27H22ClNO2
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1
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| 1 |
IC50 = 271 nM
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CP0096802
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20-{4-[2-(piperidin-1-yl)ethoxy]phenyl}-8,19-dioxatetracyclo[10.8.0.0^{2,7}.0^{13,18}]icosa-1(12),2(7),3,5,13,15,17-heptaene-5,16-diol
Show/Hide
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C31H33NO5
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1
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| 1 |
IC50 = 280 nM
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CP0149030
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(R)-5-[4-(2-Dimethylamino-ethoxy)-phenyl]-11,12-dihydro-5H-6,13-dioxa-benzo[3,4]cyclohepta[1,2-a]naphthalene-2,8-diol
Show/Hide
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C27H27NO5
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1
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| 1 |
IC50 = 293 nM
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CP0454558
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(E)-3-[4-[2-(4-tert-butylphenyl)-6-hydroxy-1-methyl-3,4-dihydroisoquinolin-1-yl]phenyl]prop-2-enoic acid
Show/Hide
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C29H31NO3
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1
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| 1 |
IC50 = 302 nM
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CP0458515
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(E)-3-(4-((6-hydroxy-2- (4-hydroxyphenyl)- benzo[b]thiophen-3- yl)oxy)phenyl)but-2- enoic acid
Show/Hide
|
C24H18O5S
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1
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| 1 |
IC50 = 316 nM
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CP0347201
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(E)-3-[4-[[7-hydroxy-6-methyl-2-oxo-3-[4-(trifluoromethoxy)phenyl]chromen-4-yl]methyl]phenyl]prop-2-enoic acid
Show/Hide
|
C27H19F3O6
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1
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| 1 |
IC50 = 320 nM
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CP0476178
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(E)-3-(4-((6-hydroxy-2- (4-hydroxy-3- methylphenyl)benzo[b] thiophen-3- yl)oxy)phenyl)acrylic acid
Show/Hide
|
C24H18O5S
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1
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| 1 |
IC50 = 327 nM
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CP0172561
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(E)-3-[4-[[7-hydroxy-3-(4-methoxyphenyl)-2-oxochromen-4-yl]methyl]phenyl]prop-2-enoic acid
Show/Hide
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C26H20O6
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1
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| 1 |
IC50 = 350 nM
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CP0271993
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(S)-5-[4-(2-Azepan-1-yl-ethoxy)-phenyl]-11,12-dihydro-5H-6,13-dioxa-benzo[3,4]cyclohepta[1,2-a]naphthalene-2,8-diol
Show/Hide
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C31H33NO5
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1
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| 1 |
IC50 = 401 nM
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CP0271994
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5S-(-)-[4-(2-diisopropylaminoethoxy)phenyl]-11,12-dihydro-5H-6,13-dioxabenzo[3,4]cyclohepta-[1,2-a]naphthalene-2,8-diol
Show/Hide
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C31H35NO5
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1
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| 1 |
IC50 = 424 nM
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CP0476667
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ethyl 5-[4-(4-hydroxy-3-methylphenyl)heptan-4-yl]-1H-pyrrole-2-carboxylate
Show/Hide
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C21H29NO3
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1
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| 1 |
IC50 = 450 nM
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CP0442387
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(E)-3-[4-[[3-(4-chlorophenyl)-7-hydroxy-2-oxochromen-4-yl]methyl]phenyl]prop-2-enoic acid
Show/Hide
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C25H17ClO5
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1
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| 1 |
IC50 = 471 nM
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CP0361695
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(E)-3-[4-[(E)-2-(2,3-dichlorophenyl)-1-(1H-indol-2-yl)but-1-enyl]phenyl]prop-2-enoic acid
Show/Hide
|
C27H21Cl2NO2
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1
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| 1 |
IC50 = 495 nM
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CP0447301
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(E)-3-[4-[2-(3-fluorophenyl)-6-hydroxy-1-methyl-3,4-dihydroisoquinolin-1-yl]phenyl]prop-2-enoic acid
Show/Hide
|
C25H22FNO3
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1
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| 1 |
IC50 = 505 nM
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CP0483131
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(E)-3-[4-[7-(difluoromethyl)-3-[2-methyl-4-(trifluoromethoxy)phenyl]-2-oxochromen-4-yl]oxyphenyl]prop-2-enoic acid
Show/Hide
|
C27H17F5O6
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1
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| 1 |
IC50 = 506 nM
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CP0479568
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(E)-3-[4-[8-fluoro-3-(4-fluoro-2-methylphenyl)-7-hydroxy-2-oxochromen-4-yl]oxyphenyl]prop-2-enoic acid
Show/Hide
|
C25H16F2O6
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1
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| 1 |
IC50 = 509 nM
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CP0501232
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(E)-3-[4-[[7-hydroxy-2-oxo-3-[4-(trifluoromethyl)phenyl]chromen-4-yl]methyl]phenyl]prop-2-enoic acid
Show/Hide
|
C26H17F3O5
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1
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| 1 |
IC50 = 531 nM
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CP0505211
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(E)-3-[4-[(1S)-6-hydroxy-1-methyl-2-(2-methylpropyl)-3,4-dihydroisoquinolin-1-yl]phenyl]prop-2-enoic acid
Show/Hide
|
C23H27NO3
|
1
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| 1 |
IC50 = 590 nM
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CP0481924
|
US10058534, 26
Show/Hide
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C24H18O5S
|
1
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| 1 |
IC50 = 647 nM
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CP0347199
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(E)-3-[4-[[3-(2,4-difluorophenyl)-7-hydroxy-2-oxochromen-4-yl]methyl]phenyl]prop-2-enoic acid
Show/Hide
|
C25H16F2O5
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1
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| 1 |
IC50 = 660 nM
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CP0149118
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(S)-5-[4-(2-Dimethylamino-ethoxy)-phenyl]-11,12-dihydro-5H-6,13-dioxa-benzo[3,4]cyclohepta[1,2-a]naphthalene-2,8-diol
Show/Hide
|
C27H27NO5
|
1
|
| 1 |
IC50 = 687 nM
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CP0271988
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(S)-5-[4-(2-Pyrrolidin-1-yl-ethoxy)-phenyl]-11,12-dihydro-5H-6,13-dioxa-benzo[3,4]cyclohepta[1,2-a]naphthalene-2,8-diol
Show/Hide
|
C29H29NO5
|
1
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| 1 |
IC50 = 688 nM
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CP0573122
|
(E)-3-[4-[(E)-2-(4-cyanophenyl)-1-(1H-indol-2-yl)but-1-enyl]phenyl]prop-2-enoic acid
Show/Hide
|
C28H22N2O2
|
1
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| 1 |
IC50 = 723 nM
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CP0206908
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3-[(1R,3R)-1-(4-chlorophenyl)-3-methyl-1,3,4,9-tetrahydropyrido[3,4-b]indol-2-yl]propanoic acid
Show/Hide
|
C21H21ClN2O2
|
1
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| 1 |
IC50 = 776.25 nM
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CP0352779
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(R)-5-[4-(2-Morpholin-4-yl-ethoxy)-phenyl]-11,12-dihydro-5H-6,13-dioxa-benzo[3,4]cyclohepta[1,2-a]naphthalene-2,8-diol
Show/Hide
|
C29H29NO6
|
1
|
| 1 |
IC50 = 816 nM
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|
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CP0481922
|
US10058534, 28
Show/Hide
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C24H18O5S
|
1
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| 1 |
IC50 = 886 nM
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CP0567140
|
US10058534, 3
Show/Hide
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C24H15F3O4S
|
1
|
| 1 |
IC50 = 941 nM
|
|
|
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CP0243827
|
(E)-3-[4-[[3-(4-fluoro-2-methylphenyl)-7-(hydroxymethyl)-2-oxochromen-4-yl]methyl]phenyl]prop-2-enoic acid
Show/Hide
|
C27H21FO5
|
1
|
| 1 |
IC50 = 1000 nM
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|
|
|
CP0508369
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2-(4-fluorophenyl)-1-methyl-1-[4-[(E)-2-(2H-tetrazol-5-yl)ethenyl]phenyl]-3,4-dihydroisoquinolin-6-ol
Show/Hide
|
C25H22FN5O
|
1
|
| 1 |
IC50 = 1030 nM
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|
|
|
CP0538804
|
(E)-3-(4-((6-hydroxy-2- (4-hydroxyphenyl)- benzo[b]thiophen-3- yl)oxy)-3- methylphenyl)acrylic acid
Show/Hide
|
C24H18O5S
|
1
|
| 1 |
IC50 = 1030 nM
|
|
|
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CP0448667
|
(E)-3-[4-[(1S)-6-hydroxy-2-(4-propan-2-ylphenyl)-1-(trifluoromethyl)-3,4-dihydroisoquinolin-1-yl]phenyl]prop-2-enoic acid
Show/Hide
|
C28H26F3NO3
|
1
|
| 1 |
IC50 = 1138 nM
|
|
|
|
CP0454556
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(E)-N-(2,2-difluoroethyl)-3-[4-[2-(4-fluorophenyl)-6-hydroxy-1-methyl-3,4-dihydroisoquinolin-1-yl]phenyl]prop-2-enamide
Show/Hide
|
C27H25F3N2O2
|
1
|
| 1 |
IC50 = 1174 nM
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|
|
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CP0188529
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2-[1-(4-chlorophenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indol-2-yl]ethanol
Show/Hide
|
C19H19ClN2O
|
1
|
| 1 |
IC50 = 1174.9 nM
|
|
|
|
CP0302561
|
(E)-3-[4-[(7-hydroxy-2-oxo-3-phenylchromen-4-yl)methyl]phenyl]prop-2-enoic acid
Show/Hide
|
C25H18O5
|
3
|
| 1 |
IC50 = 1180 nM
|
|
|
| 2 |
IC50 = 1500 nM
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|
|
| 3 |
IC50 > 100000 nM
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|
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CP0149119
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(R)-5-[4-(3-Piperidin-1-yl-propoxy)-phenyl]-11,12-dihydro-5H-6,13-dioxa-benzo[3,4]cyclohepta[1,2-a]naphthalene-2,8-diol
Show/Hide
|
C31H33NO5
|
1
|
| 1 |
IC50 = 1200 nM
|
|
|
|
CP0165906
|
(S)-5-[4-(2-Diethylamino-ethoxy)-phenyl]-8-fluoro-11,12-dihydro-5H-6,13-dioxa-benzo[3,4]cyclohepta[1,2-a]naphthalen-2-ol
Show/Hide
|
C29H30FNO4
|
1
|
| 1 |
IC50 = 1200 nM
|
|
|
|
CP0149117
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(R)-2-Methoxy-5-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-11,12-dihydro-5H-6,13-dioxa-benzo[3,4]cyclohepta[1,2-a]naphthalen-8-ol
Show/Hide
|
C31H33NO5
|
1
|
| 1 |
IC50 = 1210 nM
|
|
|
|
CP0317079
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5R-[4-(2-piperidin-1-ylethoxy)phenyl]-11,12-dihydro-5H-6,13-dioxabenzo[3,4]cyclohepta[1,2-a]naphthalen-2-ol
Show/Hide
|
C30H31NO4
|
1
|
| 1 |
IC50 = 1210 nM
|
|
|
|
CP0181776
|
5S-(+)-[4-(2-piperidin-1-ylethoxy)phenyl]-11,12-dihydro-5H-6,13-dioxabenzo[3,4]cyclohepta[1,2-a]naphthalen-2-ol
Show/Hide
|
C30H31NO4
|
1
|
| 1 |
IC50 = 1236 nM
|
|
|
|
CP0265683
|
(S)-2-Methoxy-5-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-11,12-dihydro-5H-6,13-dioxa-benzo[3,4]cyclohepta[1,2-a]naphthalen-8-ol
Show/Hide
|
C31H33NO5
|
1
|
| 1 |
IC50 = 1236 nM
|
|
|
|
CP0557963
|
(E)-3-(4-((6-hydroxy-2- (4-hydroxyphenyl)- benzo[b]thiophen-3- yl)oxy)-2- methylphenyl)acrylic acid
Show/Hide
|
C24H18O5S
|
1
|
| 1 |
IC50 = 1270 nM
|
|
|
|
CP0055817
|
(E)-3-[4-[[3-(4-fluorophenyl)-7-hydroxy-2-oxochromen-4-yl]methyl]phenyl]prop-2-enoic acid
Show/Hide
|
C25H17FO5
|
1
|
| 1 |
IC50 = 1280 nM
|
|
|
|
CP0236096
|
(R)-5-[4-(2-Azepan-1-yl-ethoxy)-phenyl]-8-fluoro-11,12-dihydro-5H-6,13-dioxa-benzo[3,4]cyclohepta[1,2-a]naphthalen-2-ol
Show/Hide
|
C31H32FNO4
|
1
|
| 1 |
IC50 = 1300 nM
|
|
|
|
CP0241149
|
(E)-3-[4-[[2-oxo-3-[4-(trifluoromethoxy)phenyl]chromen-4-yl]methyl]phenyl]prop-2-enoic acid
Show/Hide
|
C26H17F3O5
|
1
|
| 1 |
IC50 = 1300 nM
|
|
|
|
CP0251825
|
(E)-3-[4-[(1R,3R)-2-(2-hydroxyethyl)-3-methyl-1,3,4,9-tetrahydropyrido[3,4-b]indol-1-yl]phenyl]prop-2-enoic acid
Show/Hide
|
C23H24N2O3
|
1
|
| 1 |
IC50 = 1318.26 nM
|
|
|
|
CP0149115
|
5R-(+)-[4-(2-dimethylaminoethoxy)phenyl]-11,12-dihydro-5H-6,13-dioxabenzo[3,4]cyclohepta[1,2-a]naphthalen-2-ol
Show/Hide
|
C27H27NO4
|
1
|
| 1 |
IC50 = 1350 nM
|
|
|
|
CP0271989
|
5S-(-)-[4-(2-Dimethylamino-ethoxy)-phenyl]-11,12-dihydro-5H-6,13-dioxa benzo[3,4]cyclohepta[1,2-a]naphthalen-8-ol
Show/Hide
|
C27H27NO4
|
1
|
| 1 |
IC50 = 1350 nM
|
|
|
|
CP0274557
|
(S)-5-[4-(2-Azepan-1-yl-ethoxy)-phenyl]-8-fluoro-11,12-dihydro-5H-6,13-dioxa-benzo[3,4]cyclohepta[1,2-a]naphthalen-2-ol
Show/Hide
|
C31H32FNO4
|
1
|
| 1 |
IC50 = 1355 nM
|
|
|
|
CP0553696
|
(E)-3-[4-[[7-amino-3-(4-fluoro-2-methylphenyl)-2-oxochromen-4-yl]methyl]phenyl]prop-2-enoic acid
Show/Hide
|
C26H20FNO4
|
1
|
| 1 |
IC50 = 1380 nM
|
|
|
|
CP0537165
|
(E)-3-[4-[(E)-2-(4-chloro-3-methylphenyl)-1-(1H-indol-2-yl)but-1-enyl]phenyl]prop-2-enoic acid
Show/Hide
|
C28H24ClNO2
|
1
|
| 1 |
IC50 = 1389 nM
|
|
|
|
CP0465149
|
2-(4-fluorophenyl)-1-methyl-1-[4-[(E)-2-(1-methyltetrazol-5-yl)ethenyl]phenyl]-3,4-dihydroisoquinolin-6-ol
Show/Hide
|
C26H24FN5O
|
1
|
| 1 |
IC50 = 1409 nM
|
|
|
|
CP0442388
|
(E)-3-[4-[[3-(4-fluoro-2-methylphenyl)-7-hydroxy-2-oxochromen-4-yl]amino]phenyl]prop-2-enoic acid
Show/Hide
|
C25H18FNO5
|
1
|
| 1 |
IC50 = 1450 nM
|
|
|
|
CP0191133
|
5S-(-)-[4-(2-dimethylaminoethoxy)phenyl]-11,12-dihydro-5H-6,13-dioxabenzo[3,4]cyclohepta[1,2-a]naphthalen-2-ol
Show/Hide
|
C27H27NO4
|
1
|
| 1 |
IC50 = 1456 nM
|
|
|
|
CP0271991
|
(R)-5-{4-[2-(4-Methyl-piperazin-1-yl)-ethoxy]-phenyl}-11,12-dihydro-5H-6,13-dioxa-benzo[3,4]cyclohepta[1,2-a]naphthalene-2,8-diol
Show/Hide
|
C30H32N2O5
|
1
|
| 1 |
IC50 = 1550 nM
|
|
|
|
CP0151313
|
5R-(+)-[4-(2-diethylaminoethoxy)phenyl]-11,12-dihydro-5H-6,13-dioxabenzo[3,4]cyclohepta[1,2-a]naphthalen-2-ol
Show/Hide
|
C29H31NO4
|
1
|
| 1 |
IC50 = 1570 nM
|
|
|
|
CP0271992
|
(R)-5-[4-(2-Diethylamino-ethoxy)-phenyl]-8-fluoro-11,12-dihydro-5H-6,13-dioxa-benzo[3,4]cyclohepta[1,2-a]naphthalen-2-ol
Show/Hide
|
C29H30FNO4
|
1
|
| 1 |
IC50 = 1570 nM
|
|
|
|
CP0003923
|
(2-{4-[(1Z)-1,2-diphenylbut-1-en-1-yl]phenoxy}ethyl)dimethylamine
Show/Hide
|
C26H29NO
|
2
|
| 1 |
IC50 = 1605 nM
|
|
|
| 2 |
IC50 = 10000 nM
|
|
|
|
CP0306439
|
5S-(-)-[4-(2-diethylaminoethoxy)phenyl]-11,12-dihydro-5H-6,13-dioxabenzo-[3,4]cyclohepta[1,2-a]naphthalen-2-ol
Show/Hide
|
C29H31NO4
|
1
|
| 1 |
IC50 = 1660 nM
|
|
|
|
CP0481178
|
(E)-3-[4-[[7-hydroxy-2-oxo-3-[3-(trifluoromethoxy)phenyl]chromen-4-yl]methyl]phenyl]prop-2-enoic acid
Show/Hide
|
C26H17F3O6
|
1
|
| 1 |
IC50 = 1710 nM
|
|
|
|
CP0149026
|
(S)-5-[4-(3-Piperidin-1-yl-propoxy)-phenyl]-11,12-dihydro-5H-6,13-dioxa-benzo[3,4]cyclohepta[1,2-a]naphthalene-2,8-diol
Show/Hide
|
C31H33NO5
|
1
|
| 1 |
IC50 = 1800 nM
|
|
|
|
CP0563114
|
(E)-3-[4-[[2-(4-fluorophenyl)-6-hydroxy-1-benzothiophen-3-yl]oxy]phenyl]prop-2-enoic acid
Show/Hide
|
C23H15FO4S
|
1
|
| 1 |
IC50 = 1823 nM
|
|
|
|
CP0274537
|
5S-(-)-[4-(2-azepan-1-ylethoxy)phenyl]-11,12-dihydro-5H-6,13-dioxabenzo[3,4]cyclohepta[1,2-a]naphthalen-8-ol
Show/Hide
|
C31H33NO4
|
1
|
| 1 |
IC50 = 1844 nM
|
|
|
|
CP0315839
|
5S-(-)-[4-(2-azepan-1-ylethoxy)phenyl]-11,12-dihydro-5H-6,13-dioxabenzo[3,4]cyclohepta[1,2-a]naphthalen-2-ol
Show/Hide
|
C31H33NO4
|
1
|
| 1 |
IC50 = 1920 nM
|
|
|
|
CP0287047
|
(E)-3-[4-[[3-(4-fluoro-2-methoxyphenyl)-7-hydroxy-2-oxochromen-4-yl]methyl]phenyl]prop-2-enoic acid
Show/Hide
|
C26H19FO6
|
1
|
| 1 |
IC50 = 2260 nM
|
|
|
|
CP0517313
|
(E)-3-[4-[(E)-2-[4-chloro-3-(trifluoromethyl)phenyl]-1-(1H-indol-2-yl)but-1-enyl]phenyl]prop-2-enoic acid
Show/Hide
|
C28H21ClF3NO2
|
1
|
| 1 |
IC50 = 2449 nM
|
|
|
|
CP0265682
|
(R)-5-[4-(2-Thiomorpholin-4-yl-ethoxy)-phenyl]-11,12-dihydro-5H-6,13-dioxa-benzo[3,4]cyclohepta[1,2-a]naphthalene-2,8-diol
Show/Hide
|
C29H29NO5S
|
1
|
| 1 |
IC50 = 2460 nM
|
|
|
|
CP0468724
|
2-(4-fluorophenyl)-1-methyl-1-[4-[(E)-2-(1-methylimidazol-4-yl)ethenyl]phenyl]-3,4-dihydroisoquinolin-6-ol
Show/Hide
|
C28H26FN3O
|
1
|
| 1 |
IC50 = 2564 nM
|
|
|
|
CP0302558
|
(E)-3-[4-[[7-hydroxy-3-(3-methylphenyl)-2-oxochromen-4-yl]methyl]phenyl]prop-2-enoic acid
Show/Hide
|
C26H20O5
|
1
|
| 1 |
IC50 = 3090 nM
|
|
|
|
CP0557964
|
(E)-3-[4-[[6-hydroxy-2-(4-hydroxyphenyl)-1-benzothiophen-3-yl]-methylamino]phenyl]prop-2-enoic acid
Show/Hide
|
C24H19NO4S
|
1
|
| 1 |
IC50 = 3400 nM
|
|
|
|
CP0302560
|
(E)-3-[4-[[7-methoxy-2-oxo-3-[4-(trifluoromethoxy)phenyl]chromen-4-yl]methyl]phenyl]prop-2-enoic acid
Show/Hide
|
C27H19F3O6
|
1
|
| 1 |
IC50 = 3600 nM
|
|
|
|
CP0188528
|
3-[1-(4-chlorophenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indol-2-yl]propanoic acid
Show/Hide
|
C20H19ClN2O2
|
1
|
| 1 |
IC50 = 3715.35 nM
|
|
|
|
CP0481920
|
(E)-3-(4-((6-hydroxy-2- (4-hydroxyphenyl)- benzo[b]thiophen-3- yl)oxy)-2- methylphenyl)acrylic acid
Show/Hide
|
C24H18O6S
|
1
|
| 1 |
IC50 = 5020 nM
|
|
|
|
CP0448222
|
(E)-3-[4-[[7-hydroxy-3-(3-methoxyphenyl)-2-oxochromen-4-yl]methyl]phenyl]prop-2-enoic acid
Show/Hide
|
C26H20O6
|
1
|
| 1 |
IC50 = 5640 nM
|
|
|
|
CP0055818
|
(E)-3-[4-[[7-hydroxy-8-methyl-2-oxo-3-[4-(trifluoromethoxy)phenyl]chromen-4-yl]methyl]phenyl]prop-2-enoic acid
Show/Hide
|
C27H19F3O6
|
1
|
| 1 |
IC50 = 5840 nM
|
|
|
|
CP0517796
|
US10058534, 29
Show/Hide
|
C22H15NO5S
|
1
|
| 1 |
IC50 = 7750 nM
|
|
|
|
CP0045844
|
1-{2-[4-((R)-2,8-Dimethoxy-11,12-dihydro-5H-6,13-dioxa-benzo[3,4]cyclohepta[1,2-a]naphthalen-5-yl)-phenoxy]-ethyl}-piperidine
Show/Hide
|
C32H35NO5
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0045959
|
1-{2-[4-((S)-2,8-Dihydroxy-11,12-dihydro-5H-6,13-dioxa-benzo[3,4]cyclohepta[1,2-a]naphthalen-5-yl)-phenoxy]-ethyl}-pyrrolidine-2,5-dione
Show/Hide
|
C29H25NO7
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0074060
|
5S-[3-(2-Thiomorpholin-4-ylethoxy)phenyl]-11,12-dihydro-5H-6,13-dioxabenzo[3,4]cyclohepta[1,2-a]naphthalene-2,8-diol
Show/Hide
|
C29H29NO5S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0074205
|
(S)-5-[3-(2-Piperidin-1-yl-ethoxy)-phenyl]-11,12-dihydro-5H-6,13-dioxa-benzo[3,4]cyclohepta[1,2-a]naphthalene-2,8-diol
Show/Hide
|
C30H31NO5
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0149031
|
methyl 2-[4-(5,15-dihydroxy-8,18-dioxatetracyclo[9.8.0.02,7.012,17]nonadeca-1(11),2(7),3,5,12(17),13,15-heptaen-19-yl)phenoxy]acetate
Show/Hide
|
C26H22O7
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0150784
|
(S)-5-[4-(2-Morpholin-4-yl-ethoxy)-phenyl]-11,12-dihydro-5H-6,13-dioxa-benzo[3,4]cyclohepta[1,2-a]naphthalene-2,8-diol
Show/Hide
|
C29H29NO6
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0151315
|
1-{2-[4-((R)-2,8-Dihydroxy-11,12-dihydro-5H-6,13-dioxa-benzo[3,4]cyclohepta[1,2-a]naphthalen-5-yl)-phenoxy]-ethyl}-pyrrolidine-2,5-dione
Show/Hide
|
C29H25NO7
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0165904
|
(S)-5-{4-[2-(4-Methyl-piperazin-1-yl)-ethoxy]-phenyl}-11,12-dihydro-5H-6,13-dioxa-benzo[3,4]cyclohepta[1,2-a]naphthalene-2,8-diol
Show/Hide
|
C30H32N2O5
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0181777
|
5R-(+)-[4-(2-azepan-1-ylethoxy)phenyl]-11,12-dihydro-5H-6,13-dioxabenzo[3,4]cyclohepta[1,2-a]naphthalen-2-ol
Show/Hide
|
C31H33NO4
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0181778
|
(S)-5-{3-[2-(4-Methyl-piperazin-1-yl)-ethoxy]-phenyl}-11,12-dihydro-5H-6,13-dioxa-benzo[3,4]cyclohepta[1,2-a]naphthalene-2,8-diol
Show/Hide
|
C30H32N2O5
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0264845
|
5R-(+)-[4-(2-azepan-1-ylethoxy)phenyl]-11,12-dihydro-5H-6,13-dioxabenzo[3,4]cyclohepta[1,2-a]naphthalen-8-ol
Show/Hide
|
C31H33NO4
|
1
|
| 1 |
IC50 = 10000 nM
|
|
|
|
CP0264846
|
(R)-5-[3-(2-Piperidin-1-yl-ethoxy)-phenyl]-11,12-dihydro-5H-6,13-dioxa-benzo[3,4]cyclohepta[1,2-a]naphthalene-2,8-diol
Show/Hide
|
C30H31NO5
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0264848
|
5-[4-(3-Hydroxypropoxy)phenyl]-11,12-dihydro-5H-6,13-dioxabenzo[3,4]cyclohepta[1,2-a]naphthal ene-2,8-diol
Show/Hide
|
C26H24O6
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0264850
|
1-{2-[4-((S)-2,8-Dimethoxy-11,12-dihydro-5H-6,13-dioxa-benzo[3,4]cyclohepta[1,2-a]naphthalen-5-yl)-phenoxy]-ethyl}-piperidine
Show/Hide
|
C32H35NO5
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0265684
|
5R-(+)-[4-(2-Dimethylamino-ethoxy)-phenyl]-11,12-dihydro-5H-6,13-dioxabenzo[3,4]cyclohepta[1,2-a]naphthalen-8-ol
Show/Hide
|
C27H27NO4
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0271990
|
3-[4-((S)-2,8-Dihydroxy-11,12-dihydro-5H-6,13-dioxa-benzo[3,4]cyclohepta[1,2-a]naphthalen-5-yl)-phenoxy]-propionic acid
Show/Hide
|
C26H22O7
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0271995
|
1-{3-[4-((S)-2,8-Dihydroxy-11,12-dihydro-5H-6,13-dioxa-benzo[3,4]cyclohepta[1,2-a]naphthalen-5-yl)-phenoxy]-propyl}-pyrrolidine-2,5-dione
Show/Hide
|
C30H27NO7
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0271996
|
(R)-5-[3-(2-Thiomorpholin-4-yl-ethoxy)-phenyl]-11,12-dihydro-5H-6,13-dioxa-benzo[3,4]cyclohepta[1,2-a]naphthalene-2,8-diol
Show/Hide
|
C29H29NO5S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0272307
|
(R)-5-{3-[2-(4-Methyl-piperazin-1-yl)-ethoxy]-phenyl}-11,12-dihydro-5H-6,13-dioxa-benzo[3,4]cyclohepta[1,2-a]naphthalene-2,8-diol
Show/Hide
|
C30H32N2O5
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0274555
|
3-[4-((R)-2,8-Dihydroxy-11,12-dihydro-5H-6,13-dioxa-benzo[3,4]cyclohepta[1,2-a]naphthalen-5-yl)-phenoxy]-propionic acid
Show/Hide
|
C26H22O7
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0314443
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5-[4-(2-Hydroxyethoxy)phenyl]-11,12-dihydro-5H-6,13-dioxabenzo[3,4]cyclohepta [1,2-a]naphthalene-2,8-diol
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C25H22O6
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1
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| 1 |
IC50 > 10000 nM
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CP0314444
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(S)-5-[4-(2-Thiomorpholin-4-yl-ethoxy)-phenyl]-11,12-dihydro-5H-6,13-dioxa-benzo[3,4]cyclohepta[1,2-a]naphthalene-2,8-diol
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C29H29NO5S
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1
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| 1 |
IC50 > 10000 nM
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CP0508429
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(E)-3-[4-[6-hydroxy-1-methyl-2-(2-propan-2-ylphenyl)-3,4-dihydroisoquinolin-1-yl]phenyl]prop-2-enoic acid
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C28H29NO3
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1
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| 1 |
IC50 = 10000 nM
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CP0458520
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(E)-3-[4-[6-hydroxy-2-(4-hydroxyphenyl)-1-benzothiophen-3-yl]phenyl]prop-2-enoic acid
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C23H16O4S
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1
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| 1 |
IC50 > 10000 nM
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CP0544818
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(E)-3-[4-[6-hydroxy-2-(4-hydroxyphenyl)-1-benzothiophene-3-carbonyl]phenyl]prop-2-enoic acid
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C24H16O5S
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1
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| 1 |
IC50 > 10000 nM
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CP0546247
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(E)-3-[4-[[6-hydroxy-2-(4-hydroxyphenyl)-1-benzothiophen-3-yl]amino]phenyl]prop-2-enoic acid
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C23H17NO4S
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1
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| 1 |
IC50 > 10000 nM
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CP0551069
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(E)-3-[4-[11-(2-methylpropyl)-3,11-diazatricyclo[6.4.1.04,13]trideca-1,4,6,8(13)-tetraen-12-yl]phenyl]prop-2-enoic acid
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C24H26N2O2
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1
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| 1 |
IC50 > 10000 nM
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CP0571443
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(E)-3-[4-[[7-fluoro-2-oxo-3-[4-(trifluoromethoxy)phenyl]chromen-4-yl]methyl]phenyl]prop-2-enoic acid
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C26H16F4O5
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1
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| 1 |
IC50 = 10600 nM
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CP0508462
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(E)-3-[4-[(1S)-1-(difluoromethyl)-6-hydroxy-2-(4-propan-2-ylphenyl)-3,4-dihydroisoquinolin-1-yl]phenyl]prop-2-enoic acid
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C28H27F2NO3
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1
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| 1 |
IC50 = 37500 nM
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CP0550943
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5-[(2S)-2-[4-[2-[3-(fluoromethyl)azetidin-1-yl]ethoxy]phenyl]-6-hydroxy-4-methyl-2H-chromen-3-yl]-1H-pyridin-2-one
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C27H27FN2O4
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1
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| 1 |
IC50 > 100 nM
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CP0561771
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N-[(2S)-2-[4-[2-[3-(fluoromethyl)azetidin-1-yl]ethoxy]phenyl]-3-(4-fluorophenyl)-4-methyl-2H-chromen-6-yl]acetamide
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C30H30F2N2O3
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1
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| 1 |
IC50 > 100 nM
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CP0564671
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N-[(2S)-2-[4-[2-[3-(fluoromethyl)azetidin-1-yl]ethoxy]phenyl]-4-methyl-3-phenyl-2H-chromen-6-yl]methanesulfonamide
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C29H31FN2O4S
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1
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| 1 |
IC50 > 100 nM
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CP0575376
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1-[4-[(2S)-2-[4-[2-[3-(fluoromethyl)azetidin-1-yl]ethoxy]phenyl]-6-hydroxy-4-methyl-2H-chromen-3-yl]piperidin-1-yl]ethanone
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C29H35FN2O4
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1
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| 1 |
IC50 > 100 nM
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CP0261672
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4-OHT
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C26H29NO2
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1
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| 1 |
IC50 > 100 nM
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CP0542781
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2-[4-[3-(4-aminophenyl)-7-hydroxy-2-oxochromene-4-carbonyl]phenoxy]ethylsulfamic acid
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C24H20N2O8S
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1
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| 1 |
IC50 > 100 nM
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CP0542783
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2-[1-(3,4,4a,5,6,7,8,8a-octahydro-2H-1,8-naphthyridin-1-yl)propan-2-yloxy]-1-(2,8-dihydroxy-4b,6,10b,11-tetrahydrochromeno[4,3-c]cinnolin-5-yl)ethanone
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C28H36N4O5
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1
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| 1 |
IC50 > 100 nM
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CP0542785
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2,8-dihydroxy-5-[2-oxo-3-(piperidin-1-ylmethoxy)propyl]-6H-chromeno[4,3-c]cinnolin-11-one
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C24H25N3O6
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1
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| 1 |
IC50 > 100 nM
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CP0542787
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7-hydroxy-3-(4-hydroxyphenyl)-4-[4-[2-(1H-isoquinolin-2-yl)ethoxy]benzoyl]isochromen-1-one
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C33H25NO6
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1
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| 1 |
IC50 > 100 nM
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CP0542788
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1-[2-[4-[3-(4-aminophenyl)-7-hydroxy-2-oxochromene-4-carbonyl]phenoxy]ethyl]-6-oxo-2,5-dihydropyridine-3-carboxylic acid
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C30H24N2O8
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1
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| 1 |
IC50 > 100 nM
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CP0544241
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1-[2-[4-[3-(4-aminophenyl)-7-hydroxy-2-oxo-1H-quinoline-4-carbonyl]phenoxy]ethyl]-6-oxo-2,5-dihydropyridine-3-carboxylic acid
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C30H25N3O7
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1
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| 1 |
IC50 > 100 nM
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CP0546175
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1-[2-[4-(2,8-dihydroxy-11-oxo-6H-chromeno[4,3-c]cinnolin-5-yl)-2-methylphenoxy]ethyl]-3,6-dihydro-2H-pyridine-5-carboxylic acid
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C30H27N3O7
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1
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| 1 |
IC50 > 100 nM
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CP0549814
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[7-hydroxy-3-(4-hydroxyphenyl)-2H-chromen-4-yl]-[3-methyl-4-[2-(8H-1,7-naphthyridin-7-yl)ethoxy]phenyl]methanone
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C33H28N2O5
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1
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| 1 |
IC50 > 100 nM
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CP0551244
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[4-[2-(5,7-dihydropyrrolo[3,4-b]pyridin-6-yl)ethoxy]-3-methylphenyl]-[7-hydroxy-3-(4-hydroxyphenyl)-2H-chromen-4-yl]methanone
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C32H28N2O5
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1
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| 1 |
IC50 > 100 nM
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CP0562955
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1-[2-[4-[2-[[7-hydroxy-3-(4-hydroxyphenyl)-2-oxochromen-4-yl]amino]acetyl]-2-methylphenoxy]ethyl]-3,6-dihydro-2H-pyridine-5-carboxylic acid
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C32H30N2O8
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1
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| 1 |
IC50 > 100 nM
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CP0562957
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1-[2-[4-[7-hydroxy-3-(4-hydroxyphenyl)-1-oxoisochromene-4-carbonyl]phenoxy]ethyl]pyrrolidine-2,5-dione
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C28H21NO8
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1
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| 1 |
IC50 > 100 nM
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CP0562960
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2,8-dihydroxy-5-[4-[2-(methylamino)ethoxy]phenyl]-6H-chromeno[4,3-c]cinnolin-11-one
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C24H21N3O5
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1
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| 1 |
IC50 > 100 nM
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CP0274556
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1-{3-[4-((R)-2,8-Dihydroxy-11,12-dihydro-5H-6,13-dioxa-benzo[3,4]cyclohepta[1,2-a]naphthalen-5-yl)-phenoxy]-propyl}-pyrrolidine-2,5-dione
Show/Hide
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C30H27NO7
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1
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| 1 |
IC50 > 1000 nM
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CP0488157
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(E)-3-[4-[[7-(difluoromethyl)-3-(4-fluoro-2-methylphenyl)-2-oxochromen-4-yl]methyl]phenyl]prop-2-enoic acid
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C27H19F3O4
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1
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| 1 |
IC50 > 2150 nM
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CP0448224
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(E)-3-[4-[6-fluoro-3-(4-fluoro-2-methylphenyl)-7-hydroxy-2-oxochromen-4-yl]oxyphenyl]prop-2-enoic acid
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C25H16F2O6
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1
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| 1 |
IC50 > 3000 nM
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CP0085192
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1,3-dimethoxy-5-[(Z)-2-(4-methoxyphenyl)ethenyl]benzene
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C17H18O3
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1
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| 1 |
Ki = 132 nM
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CP0085168
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1-[(Z)-2-(4-ethoxyphenyl)ethenyl]-3,5-dimethoxybenzene
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C18H20O3
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1
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| 1 |
Ki = 136 nM
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CP0274708
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1,3-dimethoxy-5-[(E)-2-(4-methoxyphenyl)ethenyl]benzene
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C17H18O3
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1
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| 1 |
Ki = 261 nM
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CP0274707
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1-[(E)-2-(4-ethoxyphenyl)ethenyl]-3,5-dimethoxybenzene
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C18H20O3
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1
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| 1 |
Ki = 380.8 nM
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CP0041805
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(E)-resveratrol
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C14H12O3
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1
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| 1 |
Ki = 785 nM
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CP0084880
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1-[(E)-2-(4-butoxyphenyl)ethenyl]-3,5-dimethoxybenzene
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C20H24O3
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1
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| 1 |
Ki > 100000 nM
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CP0084881
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1,3-dichloro-5-[(Z)-2-[3-(trifluoromethyl)phenyl]ethenyl]benzene
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C15H9Cl2F3
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1
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| 1 |
Ki > 100000 nM
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CP0139192
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1,3-dichloro-5-[(Z)-2-(4-chlorophenyl)ethenyl]benzene
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C14H9Cl3
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1
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| 1 |
Ki > 100000 nM
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CP0194970
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1,3-difluoro-5-[(E)-2-(4-methoxyphenyl)ethenyl]benzene
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C15H12F2O
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1
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| 1 |
Ki > 100000 nM
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CP0200475
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1,3-dichloro-5-[(Z)-2-(4-methoxyphenyl)ethenyl]benzene
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C15H12Cl2O
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1
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| 1 |
Ki > 100000 nM
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CP0247977
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1-[(Z)-2-(4-butoxyphenyl)ethenyl]-3,5-dimethoxybenzene
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C20H24O3
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1
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| 1 |
Ki > 100000 nM
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CP0256927
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1,3-dichloro-5-[(E)-2-(4-chlorophenyl)ethenyl]benzene
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C14H9Cl3
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1
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| 1 |
Ki > 100000 nM
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CP0259047
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1,3-dichloro-5-[(E)-2-[4-(trifluoromethyl)phenyl]ethenyl]benzene
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C15H9Cl2F3
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1
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| 1 |
Ki > 100000 nM
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CP0265147
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1-[(E)-2-(4-fluorophenyl)ethenyl]-3,5-dimethoxybenzene
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C16H15FO2
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1
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| 1 |
Ki > 100000 nM
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CP0274706
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1,3-dichloro-5-[(E)-2-(3-methoxyphenyl)ethenyl]benzene
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C15H12Cl2O
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1
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| 1 |
Ki > 100000 nM
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CP0274709
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1-[(Z)-2-(4-fluorophenyl)ethenyl]-3,5-dimethoxybenzene
Show/Hide
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C16H15FO2
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1
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| 1 |
Ki > 100000 nM
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CP0274711
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1,3-difluoro-5-[(Z)-2-(4-methoxyphenyl)ethenyl]benzene
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C15H12F2O
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1
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| 1 |
Ki > 100000 nM
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CP0309536
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1,3-bis(trifluoromethyl)-5-[(E)-2-[4-(trifluoromethyl)phenyl]ethenyl]benzene
Show/Hide
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C17H9F9
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1
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| 1 |
Ki > 100000 nM
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CP0323427
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1,3-dichloro-5-[(E)-2-[3-(trifluoromethyl)phenyl]ethenyl]benzene
Show/Hide
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C15H9Cl2F3
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1
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| 1 |
Ki > 100000 nM
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CP0323428
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1,3-dichloro-5-[(E)-2-(4-methoxyphenyl)ethenyl]benzene
Show/Hide
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C15H12Cl2O
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1
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| 1 |
Ki > 100000 nM
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CP0323429
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1,3-difluoro-5-[(E)-2-(4-fluorophenyl)ethenyl]benzene
Show/Hide
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C14H9F3
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1
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| 1 |
Ki > 100000 nM
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CP0323430
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1,3-bis(trifluoromethyl)-5-[(Z)-2-[4-(trifluoromethyl)phenyl]ethenyl]benzene
Show/Hide
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C17H9F9
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1
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| 1 |
Ki > 100000 nM
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CP0335144
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1,3-dichloro-5-[(Z)-2-(3-methoxyphenyl)ethenyl]benzene
Show/Hide
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C15H12Cl2O
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1
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| 1 |
Ki > 100000 nM
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CP0335145
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1,3-dichloro-5-[(Z)-2-[4-(trifluoromethyl)phenyl]ethenyl]benzene
Show/Hide
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C15H9Cl2F3
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1
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| 1 |
Ki > 100000 nM
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CP0449402
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1,3-difluoro-5-[(Z)-2-(4-fluorophenyl)ethenyl]benzene
Show/Hide
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C14H9F3
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1
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| 1 |
Ki > 100000 nM
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