Brief Information of the Compound and Protein
Compound Name
 Compound Info 
4-Hydroxytamoxifen
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 PubChem ID
CID: 63062
Canonical SMILES
CCC(=C(c1ccc(O)cc1)c1ccc(OCCN(C)C)cc1)c1ccccc1
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Compound Formula C26H29NO2
Compound Structure
Protein Name
 Protein Info 
Estrogen receptor
Protein Classification
Transcription factor
>
Nuclear receptor
>
Nuclear hormone receptor subfamily 3
>
Nuclear hormone receptor subfamily 3 group A
>
Nuclear hormone receptor subfamily 3 group A member 1
Uniprot ID
P03372
Gene Name
ESR1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000025 HEK-293T
 Cell Line Info 
Homo sapiens (Human)  2
1
EC50 = 8 nM
   TI
   LI
   LO
   TS
2
IC50 = 3 nM
   TI
   LI
   LO
   TS
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 70 nM
   TI
   LI
   LO
   TS
CL000083 MCF-7
 Cell Line Info 
Homo sapiens (Human)  3
1
Activity = 0.1 nM
   TI
   LI
   LO
   TS
2
IC50 = 3 nM
   TI
   LI
   LO
   TS
3
IC50 = 4897.79 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 EC50 = 15.7 nM
2 IC50 = 0.309 nM
3 IC50 = 0.5 nM
4 IC50 = 2 nM
5 IC50 = 5.6 nM
6 IC50 = 10.3 nM
7 IC50 = 17 nM
8 IC50 = 26.3 nM
9 Ki = 0.25 nM
10 Ki = 0.39 nM
11 Ki = 0.5 nM
12 Ki = 2.512 nM
13 Ki = 5.7 nM