Brief Information of the Compound and Protein
Compound Name
 Compound Info 
(E)-3-[4-[(E)-1-(4-hydroxyphenyl)-2-phenylbut-1-enyl]phenyl]prop-2-enoic acid
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 PubChem ID
CID: 9799518
SID: 14755330
Canonical SMILES
CC\C(=C(/c1ccc(O)cc1)c1ccc(\C=C\C(O)=O)cc1)c1ccccc1
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Compound Formula C25H22O3
Compound Structure
Protein Name
 Protein Info 
Estrogen receptor
Protein Classification
Transcription factor
>
Nuclear receptor
>
Nuclear hormone receptor subfamily 3
>
Nuclear hormone receptor subfamily 3 group A
>
Nuclear hormone receptor subfamily 3 group A member 1
Uniprot ID
P03372
Gene Name
ESR1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000083 MCF-7
 Cell Line Info 
Homo sapiens (Human)  6
1
EC50 = 1.7 nM
   TI
   LI
   LO
   TS
2
IC50 = 6.761 nM
   TI
   LI
   LO
   TS
3
IC50 = 7 nM
   TI
   LI
   LO
   TS
4
IC50 = 12 nM
   TI
   LI
   LO
   TS
5
IC50 = 242 nM
   TI
   LI
   LO
   TS
6
IC50 > 30000 nM
   TI
   LI
   LO
   TS
CL000043 U2OS
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 238 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 0.1445 nM
2 IC50 = 0.15 nM
3 IC50 = 5.35 nM
4 IC50 = 6 nM
5 IC50 = 43 nM
6 Ki = 2.512 nM