Brief Information of the Compound and Protein
Compound Name
 Compound Info 
(E)-3-[3,5-difluoro-4-[(1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-1,3,4,9-tetrahydropyrido[3,4-b]indol-1-yl]phenyl]prop-2-enoic acid
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 PubChem ID
CID: 86287635
Canonical SMILES
C[C@@H]1Cc2c([nH]c3ccccc23)[C@H](N1CC(C)(C)F)c1c(F)cc(\C=C\C(O)=O)cc1F
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Compound Formula C25H25F3N2O2
Compound Structure
Protein Name
 Protein Info 
Estrogen receptor
Protein Classification
Transcription factor
>
Nuclear receptor
>
Nuclear hormone receptor subfamily 3
>
Nuclear hormone receptor subfamily 3 group A
>
Nuclear hormone receptor subfamily 3 group A member 1
Uniprot ID
P03372
Gene Name
ESR1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000083 MCF-7
 Cell Line Info 
Homo sapiens (Human)  4
1
IC50 = 0.138 nM
   TI
   LI
   LO
   TS
2
IC50 = 0.18 nM
   TI
   LI
   LO
   TS
3
IC50 = 0.2089 nM
   TI
   LI
   LO
   TS
4
IC50 = 0.3162 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 0.21 nM