| Compound ID |
Compound Name |
Compound Formula |
|
CP0555922
|
4-amino-1-[(2R)-6-amino-2-[[(2R)-4-methyl-2-[[(2R)-3-phenyl-2-[[2-[[(2S)-2-phenylpropyl]amino]acetyl]amino]propanoyl]amino]pentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid
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|
C38H57N7O6
|
1
|
| 1 |
EC50 = 0.0155 nM
|
|
|
|
CP0571873
|
(2R)-N-[(2R)-6-amino-1-morpholin-4-yl-1-oxohexan-2-yl]-4-methyl-2-[[(2R)-3-phenyl-2-[[2-(3-phenylpropylamino)acetyl]amino]propanoyl]amino]pentanamide
Show/Hide
|
C36H54N6O5
|
1
|
| 1 |
EC50 = 0.045 nM
|
|
|
|
CP0507539
|
(2R)-N-[(2R)-6-amino-1-morpholin-4-yl-1-oxohexan-2-yl]-4-methyl-2-[[(2R)-3-phenyl-2-[[2-(2-phenylethylamino)acetyl]amino]propanoyl]amino]pentanamide
Show/Hide
|
C35H52N6O5
|
1
|
| 1 |
EC50 = 0.048 nM
|
|
|
|
CP0565292
|
4-amino-1-[(2R)-6-amino-2-[[(2R)-4-methyl-2-[[(2R)-3-phenyl-2-[[2-(2-phenylethylamino)acetyl]amino]propanoyl]amino]pentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid
Show/Hide
|
C37H55N7O6
|
1
|
| 1 |
EC50 = 0.054 nM
|
|
|
|
CP0551676
|
4-amino-1-[(2R)-6-amino-2-[[(2R)-4-methyl-2-[[(2R)-3-phenyl-2-[[2-[(1-phenylcyclopropyl)methylamino]acetyl]amino]propanoyl]amino]pentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid
Show/Hide
|
C39H57N7O6
|
1
|
| 1 |
EC50 = 0.057 nM
|
|
|
|
CP0426401
|
4-amino-1-[(2R)-6-amino-2-[[(2R)-4-methyl-2-[[(2R)-2-[[2-[(2-methyl-2-phenylpropyl)amino]acetyl]amino]-3-phenylpropanoyl]amino]pentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid
Show/Hide
|
C39H59N7O6
|
1
|
| 1 |
EC50 = 0.078 nM
|
|
|
|
CP0568857
|
(2R)-N-[(2R)-6-amino-1-morpholin-4-yl-1-oxohexan-2-yl]-4-methyl-2-[[(2R)-3-phenyl-2-[[2-[[(1S,2R)-2-phenylcyclopropyl]amino]acetyl]amino]propanoyl]amino]pentanamide
Show/Hide
|
C36H52N6O5
|
1
|
| 1 |
EC50 = 0.08 nM
|
|
|
|
CP0660496
|
17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5alpha-epoxy-6beta-[(4'-bromo)benzamido]morphinan-oxalate
Show/Hide
|
C29H31BrN2O8
|
3
|
| 1 |
EC50 = 0.1 nM
|
|
|
| 2 |
EC50 > 10000 nM
|
|
|
| 3 |
Ki = 0.29 nM
|
|
|
|
CP0393957
|
methyl (4aR,5S,8aS)-4-[2-[3-chloro-4-(trifluoromethyl)phenyl]acetyl]-5-[(3S)-3-hydroxypyrrolidin-1-yl]-2,3,4a,5,6,7,8,8a-octahydroquinoxaline-1-carboxylate
Show/Hide
|
C23H29ClF3N3O4
|
1
|
| 1 |
EC50 = 0.3 nM
|
|
|
|
CP0677647
|
17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5alpha-epoxy-6beta-[(4'-t-butyl)benzamido]morphinan-oxalate
Show/Hide
|
C33H40N2O8
|
4
|
| 1 |
EC50 = 0.4 nM
|
|
|
| 2 |
EC50 > 10000 nM
|
|
|
| 3 |
Ki = 0.37 nM
|
|
|
| 4 |
Ki > 10000 nM
|
|
|
|
CP0864334
|
SID50107217
Show/Hide
|
C19H27Cl3N2O
|
1
|
| 1 |
EC50 = 0.4 nM
|
|
|
|
CP0472730
|
methyl (4aR,5S,8aS)-4-[2-(3-chloro-4-fluorophenyl)acetyl]-5-[(3S)-3-fluoropyrrolidin-1-yl]-2,3,4a,5,6,7,8,8a-octahydroquinoxaline-1-carboxylate
Show/Hide
|
C22H28ClF2N3O3
|
1
|
| 1 |
EC50 = 0.4 nM
|
|
|
|
CP0677646
|
3,4-dichloro-N-[(1S,5R,13R,14R,17S)-4-(cyclopropylmethyl)-10,17-dihydroxy-12-oxa-4-azapentacyclo[9.6.1.0^{1,13}.0^{5,17}.0^{7,18}]octadeca-7(18),8,10-trien-14-yl]benzamide oxalic acid
Show/Hide
|
C29H30Cl2N2O8
|
3
|
| 1 |
EC50 = 0.9 nM
|
|
|
| 2 |
EC50 > 10000 nM
|
|
|
| 3 |
Ki = 0.34 nM
|
|
|
|
CP0393146
|
methyl (4aR,5S,8aS)-4-[2-(3,4-dichlorophenyl)acetyl]-5-[(3S)-3-hydroxypyrrolidin-1-yl]-2,3,4a,5,6,7,8,8a-octahydroquinoxaline-1-carboxylate
Show/Hide
|
C22H29Cl2N3O4
|
1
|
| 1 |
EC50 = 0.9 nM
|
|
|
|
CP0548019
|
methyl (4aR,5S,8aS)-4-[2-(3,4-dichlorophenyl)acetyl]-5-(dimethylamino)-2,3,4a,5,6,7,8,8a-octahydroquinoxaline-1-carboxylate
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|
C20H27Cl2N3O3
|
1
|
| 1 |
EC50 = 1 nM
|
|
|
|
CP0411020
|
(1S,11R,15R,16R,17S,19S)-12-(cyclopropylmethyl)-6-hydroxy-22-phenyl-2,4,18-trioxa-12,22-diazaheptacyclo[15.4.2.15,9.01,16.011,19.015,19.015,24]tetracosa-5,7,9(24)-trien-23-one
Show/Hide
|
C29H30N2O5
|
1
|
| 1 |
EC50 = 1.2 nM
|
|
|
|
CP0548522
|
1-[(4aS,8S,8aR)-8-[(3S)-3-hydroxypyrrolidin-1-yl]-4-(1,2-oxazol-3-ylmethylsulfonyl)-2,3,4a,5,6,7,8,8a-octahydroquinoxalin-1-yl]-2-(4-chloro-3-fluorophenyl)ethanone
Show/Hide
|
C24H30ClFN4O5S
|
1
|
| 1 |
EC50 = 1.4 nM
|
|
|
|
CP0393960
|
1-[(4aS,8S,8aR)-4-methylsulfonyl-8-pyrrolidin-1-yl-2,3,4a,5,6,7,8,8a-octahydroquinoxalin-1-yl]-2-(3,4-dichlorophenyl)ethanone
Show/Hide
|
C21H29Cl2N3O3S
|
1
|
| 1 |
EC50 = 1.5 nM
|
|
|
|
CP0393149
|
methyl 2-[(4aR,5S,8aS)-4-[2-(3,4-dichlorophenyl)acetyl]-5-pyrrolidin-1-yl-2,3,4a,5,6,7,8,8a-octahydroquinoxalin-1-yl]acetate
Show/Hide
|
C23H31Cl2N3O3
|
1
|
| 1 |
EC50 = 1.7 nM
|
|
|
|
CP0551860
|
1-[(4aS,8S,8aR)-8-[(3S)-3-hydroxypyrrolidin-1-yl]-4-methylsulfonyl-2,3,4a,5,6,7,8,8a-octahydroquinoxalin-1-yl]-2-(3,4-dichlorophenyl)ethanone
Show/Hide
|
C21H29Cl2N3O4S
|
1
|
| 1 |
EC50 = 1.8 nM
|
|
|
|
CP0380133
|
methyl (4aR,5S,8aS)-4-[2-(3,4-dichlorophenyl)acetyl]-5-pyrrolidin-1-yl-2,3,4a,5,6,7,8,8a-octahydroquinoxaline-1-carboxylate
Show/Hide
|
C22H29Cl2N3O3
|
1
|
| 1 |
EC50 = 2 nM
|
|
|
|
CP0393148
|
methyl (4aR,5S,8aS)-4-[2-(3-chloro-4-fluorophenyl)acetyl]-5-[(3S)-3-hydroxypyrrolidin-1-yl]-2,3,4a,5,6,7,8,8a-octahydroquinoxaline-1-carboxylate
Show/Hide
|
C22H29ClFN3O4
|
1
|
| 1 |
EC50 = 2.2 nM
|
|
|
|
CP0548023
|
(4aR,5S,8aS)-4-[2-(3,4-dichlorophenyl)acetyl]-N,N-dimethyl-5-pyrrolidin-1-yl-2,3,4a,5,6,7,8,8a-octahydroquinoxaline-1-sulfonamide
Show/Hide
|
C22H32Cl2N4O3S
|
1
|
| 1 |
EC50 = 2.2 nM
|
|
|
|
CP0668279
|
17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5alpha-epoxy-6beta-[(4'-methyl)benzamido]morphinan-oxalate
Show/Hide
|
C30H34N2O8
|
4
|
| 1 |
EC50 = 2.4 nM
|
|
|
| 2 |
EC50 > 10000 nM
|
|
|
| 3 |
Ki = 0.015 nM
|
|
|
| 4 |
Ki = 0.11 nM
|
|
|
|
CP0397222
|
(1S,11R,15R,16R,17S,19S)-12-(cyclopropylmethyl)-6-hydroxy-22-(2-phenylethyl)-2,4,18-trioxa-12,22-diazaheptacyclo[15.4.2.15,9.01,16.011,19.015,19.015,24]tetracosa-5,7,9(24)-trien-23-one
Show/Hide
|
C31H34N2O5
|
1
|
| 1 |
EC50 = 2.4 nM
|
|
|
|
CP0393150
|
ethyl 2-[(4aR,5S,8aS)-4-[2-(3,4-dichlorophenyl)acetyl]-5-pyrrolidin-1-yl-2,3,4a,5,6,7,8,8a-octahydroquinoxalin-1-yl]acetate
Show/Hide
|
C24H33Cl2N3O3
|
1
|
| 1 |
EC50 = 3.2 nM
|
|
|
|
CP0438573
|
1-[(4aS,8S,8aS)-8-pyrrolidin-1-yl-3,4,4a,5,6,7,8,8a-octahydro-2H-quinoxalin-1-yl]-2-(3,4-dichlorophenyl)ethanone
Show/Hide
|
C20H27Cl2N3O
|
1
|
| 1 |
EC50 = 3.7 nM
|
|
|
|
CP0519692
|
methyl (4aR,5S,8aS)-4-[2-(4-chloro-3-fluorophenyl)acetyl]-5-[(3S)-3-hydroxypyrrolidin-1-yl]-2,3,4a,5,6,7,8,8a-octahydroquinoxaline-1-carboxylate
Show/Hide
|
C22H29ClFN3O4
|
1
|
| 1 |
EC50 = 3.9 nM
|
|
|
|
CP0552351
|
(4aR,5S,8aS)-4-[2-(3,4-dichlorophenyl)acetyl]-N-propan-2-yl-5-pyrrolidin-1-yl-2,3,4a,5,6,7,8,8a-octahydroquinoxaline-1-carboxamide
Show/Hide
|
C24H34Cl2N4O2
|
1
|
| 1 |
EC50 = 4.5 nM
|
|
|
|
CP0521044
|
methyl (4aR,5S,8aS)-4-[2-(3,4-dichlorophenyl)acetyl]-5-[(3R)-3-hydroxypyrrolidin-1-yl]-2,3,4a,5,6,7,8,8a-octahydroquinoxaline-1-carboxylate
Show/Hide
|
C22H29Cl2N3O4
|
1
|
| 1 |
EC50 = 4.7 nM
|
|
|
|
CP0036843
|
(2S,4aR,6aR,7R,9S,10aS,10bR)-9-(acetyloxy)-2-(furan-3-yl)dodecahydro-6a,10b-dimethyl-4,10-dioxo-2H-naphtho-[2,1-c]pyran-7-carboxylic acid methyl ester
Show/Hide
|
C23H28O8
|
2
|
| 1 |
EC50 = 5 nM
|
|
|
| 2 |
Ki = 0.8 nM
|
|
|
|
CP0393958
|
propan-2-yl 2-[(4aR,5S,8aS)-4-[2-(3,4-dichlorophenyl)acetyl]-5-pyrrolidin-1-yl-2,3,4a,5,6,7,8,8a-octahydroquinoxalin-1-yl]acetate
Show/Hide
|
C25H35Cl2N3O3
|
1
|
| 1 |
EC50 = 5 nM
|
|
|
|
CP0035617
|
N-methyl-2-phenyl-N-[(5R,7S,8S)-7-(pyrrolidin-1-yl)-1-oxaspiro[4.5]decan-8-yl]acetamide
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|
C22H32N2O2
|
7
|
| 1 |
EC50 = 5.3 nM
|
|
|
| 2 |
EC50 = 12 nM
|
|
|
| 3 |
EC50 = 80 nM
|
|
|
| 4 |
EC50 = 534 nM
|
|
|
| 5 |
ED50 = 24 nM
|
|
|
| 6 |
IC50 = 2 nM
|
|
|
| 7 |
IC50 = 8 nM
|
|
|
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CP0555739
|
1-[(4aS,8S,8aR)-8-[(3S)-3-hydroxypyrrolidin-1-yl]-4-methylsulfonyl-2,3,4a,5,6,7,8,8a-octahydroquinoxalin-1-yl]-2-(3-chloro-4-fluorophenyl)ethanone
Show/Hide
|
C21H29ClFN3O4S
|
1
|
| 1 |
EC50 = 5.9 nM
|
|
|
|
CP0465108
|
1-[(4aS,8S,8aR)-8-[(3S)-3-hydroxypyrrolidin-1-yl]-4-(1,2-oxazol-3-ylmethylsulfonyl)-2,3,4a,5,6,7,8,8a-octahydroquinoxalin-1-yl]-2-(4-chlorophenyl)ethanone
Show/Hide
|
C24H31ClN4O5S
|
1
|
| 1 |
EC50 = 6.9 nM
|
|
|
|
CP0845402
|
4-chloro-N-[(1S,5R,13R,14R,17S)-4-(cyclopropylmethyl)-10,17-dihydroxy-12-oxa-4-azapentacyclo[9.6.1.0^{1,13}.0^{5,17}.0^{7,18}]octadeca-7(18),8,10-trien-14-yl]benzamide oxalic acid
Show/Hide
|
C29H31ClN2O8
|
3
|
| 1 |
EC50 = 7.1 nM
|
|
|
| 2 |
EC50 > 10000 nM
|
|
|
| 3 |
Ki = 0.23 nM
|
|
|
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CP0548024
|
1-[(4aS,8S,8aR)-8-[(3S)-3-hydroxypyrrolidin-1-yl]-4-methylsulfonyl-2,3,4a,5,6,7,8,8a-octahydroquinoxalin-1-yl]-2-(4-chloro-3-fluorophenyl)ethanone
Show/Hide
|
C21H29ClFN3O4S
|
1
|
| 1 |
EC50 = 8 nM
|
|
|
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CP0519693
|
2-[(4aR,5S,8aS)-4-[2-(3,4-dichlorophenyl)acetyl]-5-pyrrolidin-1-yl-2,3,4a,5,6,7,8,8a-octahydroquinoxalin-1-yl]-N-methyl-2-oxoacetamide
Show/Hide
|
C23H30Cl2N4O3
|
1
|
| 1 |
EC50 = 8.1 nM
|
|
|
|
CP0401390
|
1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-[(3S)-3-piperidinyl]-1H-benzimidazole
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|
C26H40N4
|
2
|
| 1 |
EC50 = 8.4 nM
|
|
|
| 2 |
Ki = 9.2 nM
|
|
|
|
CP0676041
|
17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5alpha-epoxy-6beta-[(4'-trimethylfluoro)benzamido]morphinan-oxalate
Show/Hide
|
C30H31F3N2O8
|
4
|
| 1 |
EC50 = 9.9 nM
|
|
|
| 2 |
EC50 > 10000 nM
|
|
|
| 3 |
Ki = 0.34 nM
|
|
|
| 4 |
Ki = 0.637 nM
|
|
|
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CP0519691
|
methyl (4aR,5S,8aS)-4-[2-(3,4-difluorophenyl)acetyl]-5-[(3S)-3-hydroxypyrrolidin-1-yl]-2,3,4a,5,6,7,8,8a-octahydroquinoxaline-1-carboxylate
Show/Hide
|
C22H29F2N3O4
|
1
|
| 1 |
EC50 = 11 nM
|
|
|
|
CP0411820
|
1-(4-butyl-8-pyrrolidin-1-yl-2,3,4a,5,6,7,8,8a-octahydroquinoxalin-1-yl)-2-(3,4-dichlorophenyl)ethanone
Show/Hide
|
C24H35Cl2N3O
|
1
|
| 1 |
EC50 = 12 nM
|
|
|
|
CP0401391
|
1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-[(3S)-1-methyl-3-piperidinyl]-1H-benzimidazole
Show/Hide
|
C27H42N4
|
2
|
| 1 |
EC50 = 13 nM
|
|
|
| 2 |
Ki = 10 nM
|
|
|
|
CP0548020
|
methyl (4aR,5S,8aS)-4-[2-(4-chlorophenyl)acetyl]-5-[(3S)-3-hydroxypyrrolidin-1-yl]-2,3,4a,5,6,7,8,8a-octahydroquinoxaline-1-carboxylate
Show/Hide
|
C22H30ClN3O4
|
1
|
| 1 |
EC50 = 14 nM
|
|
|
|
CP0548520
|
methyl (4aR,5S,8aS)-4-[2-(3-chlorophenyl)acetyl]-5-[(3S)-3-hydroxypyrrolidin-1-yl]-2,3,4a,5,6,7,8,8a-octahydroquinoxaline-1-carboxylate
Show/Hide
|
C22H30ClN3O4
|
1
|
| 1 |
EC50 = 15 nM
|
|
|
|
CP0372877
|
2-(3,5-dimethylpiperazin-1-yl)-1-[1-(1-methylcyclooctyl)piperidin-4-yl]-1H-benzimidazole
Show/Hide
|
C27H43N5
|
2
|
| 1 |
EC50 = 18 nM
|
|
|
| 2 |
Ki = 15 nM
|
|
|
|
CP0376884
|
(1-{4-[2-(4-Methylpiperazin-1-yl)-1H-benzimidazol-1-yl]piperidin-1-yl}cyclooctyl)methanol
Show/Hide
|
C26H41N5O
|
2
|
| 1 |
EC50 = 18 nM
|
|
|
| 2 |
Ki = 333 nM
|
|
|
|
CP0411819
|
2-(3,4-dichlorophenyl)-1-(4-methyl-8-pyrrolidin-1-yl-2,3,4a,5,6,7,8,8a-octahydroquinoxalin-1-yl)ethanone
Show/Hide
|
C21H29Cl2N3O
|
1
|
| 1 |
EC50 = 20 nM
|
|
|
|
CP0964616
|
methyl 4-(2-(3,4-dichlorophenyl)acetyl)-5-(pyrrolidin-1-yl)octahydroquinoxaline-1(2H)-carboxylate
Show/Hide
|
C22H29Cl2N3O3
|
1
|
| 1 |
EC50 = 20 nM
|
|
|
|
CP0488298
|
2-(3,4-dichlorophenyl)-1-[4-[(4-methoxyphenyl)methyl]-8-pyrrolidin-1-yl-2,3,4a,5,6,7,8,8a-octahydroquinoxalin-1-yl]ethanone
Show/Hide
|
C28H35Cl2N3O2
|
1
|
| 1 |
EC50 = 26 nM
|
|
|
|
CP0668278
|
17-Cyclopropylmethyl-3,14beta-dihydroxy-4,5alpha-epoxy-6beta-[(4'-iodo)benzamido]morphinan-oxalate
Show/Hide
|
C29H31IN2O8
|
4
|
| 1 |
EC50 = 29 nM
|
|
|
| 2 |
EC50 > 10000 nM
|
|
|
| 3 |
Ki = 0.37 nM
|
|
|
| 4 |
Ki > 10000 nM
|
|
|
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CP0380896
|
1-[(4aR,8S,8aR)-4-benzyl-8-pyrrolidin-1-yl-2,3,4a,5,6,7,8,8a-octahydroquinoxalin-1-yl]-2-(3,4-dichlorophenyl)ethanone
Show/Hide
|
C27H33Cl2N3O
|
2
|
| 1 |
EC50 = 29 nM
|
|
|
| 2 |
EC50 = 490 nM
|
|
|
|
CP0411818
|
2-(3,4-dichlorophenyl)-1-(8-pyrrolidin-1-yl-3,4,4a,5,6,7,8,8a-octahydro-2H-quinoxalin-1-yl)ethanone
Show/Hide
|
C20H27Cl2N3O
|
1
|
| 1 |
EC50 = 33 nM
|
|
|
|
CP0850829
|
2-(3,4-Dichlorophenyl)-1-{(4aRS,8SR,8aRS)-4-[(pyridin-3-yl)-methyl]-8-(pyrrolidin-1-yl)perhydrochinoxalin-1-yl}ethan-1-one
Show/Hide
|
C26H32Cl2N4O
|
2
|
| 1 |
EC50 = 34 nM
|
|
|
| 2 |
Ki = 22 nM
|
|
|
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CP0513068
|
2-(3,4-dichlorophenyl)-1-[8-(3-hydroxypyrrolidin-1-yl)-3,4,4a,5,6,7,8,8a-octahydro-2H-quinoxalin-1-yl]ethanone
Show/Hide
|
C20H27Cl2N3O2
|
1
|
| 1 |
EC50 = 35 nM
|
|
|
|
CP0397224
|
(1S,11R,15R,16R,17S,19S)-22-benzyl-12-(cyclopropylmethyl)-6-hydroxy-2,4,18-trioxa-12,22-diazaheptacyclo[15.4.2.15,9.01,16.011,19.015,19.015,24]tetracosa-5,7,9(24)-trien-23-one
Show/Hide
|
C30H32N2O5
|
1
|
| 1 |
EC50 = 39.8 nM
|
|
|
|
CP0411821
|
2-(3,4-dichlorophenyl)-1-[4-(pyridin-2-ylmethyl)-8-pyrrolidin-1-yl-2,3,4a,5,6,7,8,8a-octahydroquinoxalin-1-yl]ethanone
Show/Hide
|
C26H32Cl2N4O
|
1
|
| 1 |
EC50 = 41 nM
|
|
|
|
CP0386133
|
2-(3-{1-[1-(1-Methylcyclooctyl)piperidin-4-yl]-1H-benzimidazol-2-yl}phenoxy)ethanol
Show/Hide
|
C29H39N3O2
|
2
|
| 1 |
EC50 = 48 nM
|
|
|
| 2 |
Ki = 43 nM
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|
|
|
CP0043300
|
ETHYLSALVINORINB-2-O-MALONATE
Show/Hide
|
C26H32O10
|
1
|
| 1 |
EC50 = 52 nM
|
|
|
|
CP0897021
|
2-(3,4-Dichlorophenyl)-1-{(4aRS,8SR,8aRS)-4-[(1H-imidazol-5-yl)methyl]-8-(pyrrolidin-1-yl)perhydroquinoxalin-1-yl}ethan-1-one
Show/Hide
|
C24H31Cl2N5O
|
1
|
| 1 |
EC50 = 56 nM
|
|
|
|
CP0474038
|
1-[4-benzyl-8-(3-hydroxypyrrolidin-1-yl)-2,3,4a,5,6,7,8,8a-octahydroquinoxalin-1-yl]-2-(3,4-dichlorophenyl)ethanone
Show/Hide
|
C27H33Cl2N3O2
|
1
|
| 1 |
EC50 = 64 nM
|
|
|
|
CP0386132
|
1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-[(3R)-1-methyl-3-piperidinyl]-1H-benzimidazole
Show/Hide
|
C27H42N4
|
2
|
| 1 |
EC50 = 70 nM
|
|
|
| 2 |
Ki = 25 nM
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|
|
|
CP0087875
|
4-O-[(2S,4aR,6aR,7R,9S,10aS,10bR)-2-(furan-3-yl)-7-methoxycarbonyl-6a,10b-dimethyl-4,10-dioxo-2,4a,5,6,7,8,9,10a-octahydro-1H-benzo[f]isochromen-9-yl] 1-O-methyl (E)-but-2-enedioate
Show/Hide
|
C26H30O10
|
1
|
| 1 |
EC50 = 70 nM
|
|
|
|
CP0860430
|
2-(3,4-Dichlorophenyl)-1-{(4aRS,8SR,8aSR)-4-[(pyridin-3-yl)-methyl]-8-[(3SR)-3-hydroxypyrrolidin-1-yl]-perhydrochinoxalin-1-yl}ethan-1-one
Show/Hide
|
C26H32Cl2N4O2
|
2
|
| 1 |
EC50 = 77 nM
|
|
|
| 2 |
Ki = 31 nM
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|
|
|
CP0508087
|
2-(3,4-dichlorophenyl)-1-[8-(3-hydroxypyrrolidin-1-yl)-4-methyl-2,3,4a,5,6,7,8,8a-octahydroquinoxalin-1-yl]ethanone
Show/Hide
|
C21H29Cl2N3O2
|
1
|
| 1 |
EC50 = 79 nM
|
|
|
|
CP0411824
|
methyl 4-[2-(3,4-dichlorophenyl)acetyl]-5-(3-hydroxypyrrolidin-1-yl)-2,3,4a,5,6,7,8,8a-octahydroquinoxaline-1-carboxylate
Show/Hide
|
C22H29Cl2N3O4
|
2
|
| 1 |
EC50 = 79 nM
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|
|
| 2 |
EC50 = 85 nM
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|
|
|
CP0386129
|
1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-[(3R)-3-piperidinyl]-1H-benzimidazole
Show/Hide
|
C26H40N4
|
2
|
| 1 |
EC50 = 80 nM
|
|
|
| 2 |
Ki = 23.1 nM
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|
|
|
CP0372512
|
(+)-Methyl(1S,2R,5R)-8-[2-(3,4-Dichlorophenyl)acetyl]-2-(pyrrolidin-1-yl)-6,8-diazabicyclo[3.2.2]nonane-6-carboxylate
Show/Hide
|
C21H27Cl2N3O3
|
2
|
| 1 |
EC50 = 87 nM
|
|
|
| 2 |
Ki = 6 nM
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|
|
|
CP0421466
|
(2R)-2-[[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]amino]-N-[(4S)-2-[3-[[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-5-(4-benzylpiperidin-1-yl)-1-oxopentan-2-yl]amino]-3-oxopropyl]-3-oxo-4,5-dihydro-1H-2-benzazepin-4-yl]-5-(diaminomethylideneamino)pentanamide
Show/Hide
|
C56H75N11O7
|
1
|
| 1 |
EC50 = 95 nM
|
|
|
|
CP0421467
|
(2S)-2-[3-[(4S)-4-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-oxo-4,5-dihydro-1H-2-benzazepin-2-yl]propanoylamino]-N-[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]-5-(diaminomethylideneamino)pentanamide
Show/Hide
|
C45H63N13O7
|
1
|
| 1 |
EC50 = 108 nM
|
|
|
|
CP0064900
|
methyl (4aR,5S,8aR)-4-[2-(3,4-dichlorophenyl)acetyl]-5-pyrrolidin-1-yl-2,3,4a,5,6,7,8,8a-octahydroquinoxaline-1-carboxylate
Show/Hide
|
C22H29Cl2N3O3
|
1
|
| 1 |
EC50 = 110 nM
|
|
|
|
CP0043298
|
3-O-[(2S,4aR,6aR,7R,9S,10aS,10bR)-2-(furan-3-yl)-7-methoxycarbonyl-6a,10b-dimethyl-4,10-dioxo-2,4a,5,6,7,8,9,10a-octahydro-1H-benzo[f]isochromen-9-yl] 1-O-methyl propanedioate
Show/Hide
|
C25H30O10
|
1
|
| 1 |
EC50 = 137 nM
|
|
|
|
CP0480593
|
ethyl 4-[2-(3,4-dichlorophenyl)acetyl]-5-pyrrolidin-1-yl-2,3,4a,5,6,7,8,8a-octahydroquinoxaline-1-carboxylate
Show/Hide
|
C23H31Cl2N3O3
|
1
|
| 1 |
EC50 = 150 nM
|
|
|
|
CP0372876
|
1-(3-{1-[1-(1-Methylcyclooctyl)piperidin-4-yl]-1H-benzimidazol-2-yl}phenyl)methanamine
Show/Hide
|
C28H38N4
|
2
|
| 1 |
EC50 = 154 nM
|
|
|
| 2 |
Ki = 72 nM
|
|
|
|
CP0411822
|
methyl 3-[4-[2-(3,4-dichlorophenyl)acetyl]-5-(3-hydroxypyrrolidin-1-yl)-2,3,4a,5,6,7,8,8a-octahydroquinoxalin-1-yl]-3-oxopropanoate
Show/Hide
|
C24H31Cl2N3O5
|
1
|
| 1 |
EC50 = 170 nM
|
|
|
|
CP0427455
|
1-{1-[1-(Hydroxymethyl)cyclooctyl]piperidin-4-yl}-1Hbenzimidazol-2(3H)-one
Show/Hide
|
C21H31N3O2
|
2
|
| 1 |
EC50 = 194 nM
|
|
|
| 2 |
Ki = 239 nM
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|
|
|
CP0379863
|
methyl 3-[4-[2-(3,4-dichlorophenyl)acetyl]-5-pyrrolidin-1-yl-2,3,4a,5,6,7,8,8a-octahydroquinoxalin-1-yl]-3-oxopropanoate
Show/Hide
|
C24H31Cl2N3O4
|
1
|
| 1 |
EC50 = 220 nM
|
|
|
|
CP0411823
|
1-(4-benzoyl-8-pyrrolidin-1-yl-2,3,4a,5,6,7,8,8a-octahydroquinoxalin-1-yl)-2-(3,4-dichlorophenyl)ethanone
Show/Hide
|
C27H31Cl2N3O2
|
1
|
| 1 |
EC50 = 260 nM
|
|
|
|
CP0410120
|
(1S,11R,15R,16R,17S,19S)-22-benzyl-6-hydroxy-12-methyl-2,4,18-trioxa-12,22-diazaheptacyclo[15.4.2.15,9.01,16.011,19.015,19.015,24]tetracosa-5,7,9(24)-trien-23-one
Show/Hide
|
C27H28N2O5
|
1
|
| 1 |
EC50 = 307 nM
|
|
|
|
CP0413580
|
1-(4-acetyl-8-pyrrolidin-1-yl-2,3,4a,5,6,7,8,8a-octahydroquinoxalin-1-yl)-2-(3,4-dichlorophenyl)ethanone
Show/Hide
|
C22H29Cl2N3O2
|
1
|
| 1 |
EC50 = 330 nM
|
|
|
|
CP0401132
|
(1S,11R,15R,16R,17S,19S)-22-benzyl-6-hydroxy-12-(2-methylpropyl)-2,4,18-trioxa-12,22-diazaheptacyclo[15.4.2.15,9.01,16.011,19.015,19.015,24]tetracosa-5,7,9(24)-trien-23-one
Show/Hide
|
C30H34N2O5
|
1
|
| 1 |
EC50 = 333 nM
|
|
|
|
CP0377808
|
(1-{4-[2-(3-Methylpiperazin-1-yl)-1H-benzimidazol-1-yl]piperidin-1-yl}cyclooctyl)methanol
Show/Hide
|
C26H41N5O
|
2
|
| 1 |
EC50 = 366 nM
|
|
|
| 2 |
Ki = 275 nM
|
|
|
|
CP0413579
|
1-[4-benzoyl-8-(3-hydroxypyrrolidin-1-yl)-2,3,4a,5,6,7,8,8a-octahydroquinoxalin-1-yl]-2-(3,4-dichlorophenyl)ethanone
Show/Hide
|
C27H31Cl2N3O3
|
1
|
| 1 |
EC50 = 470 nM
|
|
|
|
CP0421379
|
(2S)-2-[[(2S)-1-[(2S)-5-amino-2-[[(2S)-2-[[2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-5-oxopentanoyl]pyrrolidine-2-carbonyl]amino]-N-[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]pentanediamide
Show/Hide
|
C53H73N15O12
|
1
|
| 1 |
EC50 = 562.34 nM
|
|
|
|
CP0463554
|
1-[4-[2-(3,4-dichlorophenyl)acetyl]-5-pyrrolidin-1-yl-2,3,4a,5,6,7,8,8a-octahydroquinoxalin-1-yl]propan-1-one
Show/Hide
|
C23H31Cl2N3O2
|
1
|
| 1 |
EC50 = 600 nM
|
|
|
|
CP0390918
|
(+)-1-[(1S,2R,5R)-6-Benzyl-2-(pyrrolidin-1-yl)-6,8-diazabicyclo[3.2.2]nonan-8-yl]-2-(3,4-dichlorophenyl)ethanone
Show/Hide
|
C26H31Cl2N3O
|
2
|
| 1 |
EC50 = 820 nM
|
|
|
| 2 |
Ki = 70 nM
|
|
|
|
CP0108686
|
4-O-[(2S,4aR,6aR,7R,9S,10aS,10bR)-2-(furan-3-yl)-7-methoxycarbonyl-6a,10b-dimethyl-4,10-dioxo-2,4a,5,6,7,8,9,10a-octahydro-1H-benzo[f]isochromen-9-yl] 1-O-methyl butanedioate
Show/Hide
|
C26H32O10
|
1
|
| 1 |
EC50 = 855 nM
|
|
|
|
CP0395472
|
2-[(9R)-9-pyridin-2-yl-6-oxaspiro[4.5]decan-9-yl]-N-(thiophen-2-ylmethyl)ethanamine
Show/Hide
|
C21H28N2OS
|
1
|
| 1 |
EC50 = 900 nM
|
|
|
|
CP0084730
|
Oliceridine
Show/Hide
|
C22H30N2O2S
|
1
|
| 1 |
EC50 = 1400 nM
|
|
|
|
CP0386130
|
1-[1-(1-Methylcyclooctyl)piperidin-4-yl]-2-[3-(trifluoromethyl)phenyl]-1H-benzimidazole
Show/Hide
|
C28H34F3N3
|
2
|
| 1 |
EC50 = 1578 nM
|
|
|
| 2 |
Ki = 352 nM
|
|
|
|
CP0373152
|
(+)-1-{(1S,2R,5R)-8-[2-(3,4-Dichlorophenyl)acetyl]-2-(pyrrolidin-1-yl)-6,8-diazabicyclo[3.2.2]nonan-8-yl}propan-1-one
Show/Hide
|
C22H29Cl2N3O2
|
2
|
| 1 |
EC50 = 1800 nM
|
|
|
| 2 |
Ki = 120 nM
|
|
|
|
CP0041255
|
(+)-4-((alpha R)-((2S,5R)-4-allyl-2,5-dimethylpiperazin-1-yl)(3-methoxyphenyl)methyl)-N,N-diethylbenzamide
Show/Hide
|
C28H39N3O2
|
1
|
| 1 |
EC50 = 5264 nM
|
|
|
|
CP0397225
|
(1S,11R,15R,16R,17S,19S)-22-benzyl-6-hydroxy-12-(2-phenylethyl)-2,4,18-trioxa-12,22-diazaheptacyclo[15.4.2.15,9.01,16.011,19.015,19.015,24]tetracosa-5,7,9(24)-trien-23-one
Show/Hide
|
C34H34N2O5
|
1
|
| 1 |
EC50 = 12530 nM
|
|
|
|
CP0507540
|
4-amino-1-[(2R)-6-amino-2-[[(2R)-4-methyl-2-[[(2R)-3-phenyl-2-[[1-(2-phenylethylamino)cyclopropanecarbonyl]amino]propanoyl]amino]pentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid
Show/Hide
|
C39H57N7O6
|
1
|
| 1 |
EC50 > 1 nM
|
|
|
|
CP0571834
|
(2R)-N-[(2R)-6-amino-1-morpholin-4-yl-1-oxohexan-2-yl]-2-[[(2R)-2-[[2-(benzylamino)acetyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanamide
Show/Hide
|
C34H50N6O5
|
1
|
| 1 |
EC50 > 1 nM
|
|
|
|
CP0573849
|
4-amino-1-[(2R)-6-amino-2-[[(2R)-4-methyl-2-[[(2R)-3-phenyl-2-[[(2R)-2-(2-phenylethylamino)propanoyl]amino]propanoyl]amino]pentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid
Show/Hide
|
C38H57N7O6
|
1
|
| 1 |
EC50 > 1 nM
|
|
|
|
CP0578920
|
(2R)-N-[(2R)-6-amino-1-morpholin-4-yl-1-oxohexan-2-yl]-2-[[(2R)-2-[[2-(2,3-dihydro-1H-inden-2-ylamino)acetyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanamide
Show/Hide
|
C36H52N6O5
|
1
|
| 1 |
EC50 > 1 nM
|
|
|
|
CP0578921
|
(3S)-N-[(2R)-1-[[(2R)-1-[[(2R)-6-amino-1-morpholin-4-yl-1-oxohexan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide
Show/Hide
|
C35H50N6O5
|
1
|
| 1 |
EC50 > 1 nM
|
|
|
|
CP0374966
|
3-(5-Fluoro-2-methoxy-phenyl)-1-[2-(3-hydroxy-pyrrolidin-1-yl)-1-phenyl-ethyl]-1H-pyridin-2-one
Show/Hide
|
C24H25FN2O3
|
2
|
| 1 |
ED50 = 32 nM
|
|
|
| 2 |
IC50 = 5.5 nM
|
|
|
|
CP0442086
|
5-(2,4-Dichloro-phenyl)-3-(1-phenyl-2-pyrrolidin-1-yl-ethyl)-3H-pyrimidin-4-one
Show/Hide
|
C22H21Cl2N3O
|
2
|
| 1 |
ED50 = 615 nM
|
|
|
| 2 |
IC50 = 41 nM
|
|
|
|
CP0873061
|
(S)-2-amino-N-(((S)-3-((S)-1-((S)-1-amino-1-oxo-3-phenylpropan-2-ylamino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl)-2,4-dioxooxazolidin-5-yl)methyl)-3-(4-hydroxyphenyl)propanamide
Show/Hide
|
C33H34N6O7
|
2
|
| 1 |
IC50 = 0.22 nM
|
|
|
| 2 |
Ki = 9.8 nM
|
|
|
|
CP0040101
|
2-(3,4-dichlorophenyl)-N-methyl-N-[(1R,2R)-2-pyrrolidin-1-ylcyclohexyl]acetamide
Show/Hide
|
C19H26Cl2N2O
|
5
|
| 1 |
IC50 = 0.3 nM
|
|
|
| 2 |
IC50 = 0.9 nM
|
|
|
| 3 |
IC50 = 1.2 nM
|
|
|
| 4 |
Ki = 1.5 nM
|
|
|
| 5 |
Ki = 2.9 nM
|
|
|
|
CP0041449
|
C18130
Show/Hide
|
C40H43N3O6
|
2
|
| 1 |
IC50 = 2.1 nM
|
|
|
| 2 |
Ki = 0.34 nM
|
|
|
|
CP0402345
|
3-(2,4-Dichloro-phenyl)-1-(1-phenyl-2-pyrrolidin-1-yl-ethyl)-1H-pyridin-2-one
Show/Hide
|
C23H22Cl2N2O
|
1
|
| 1 |
IC50 = 2.3 nM
|
|
|
|
CP0072632
|
CAS_5985-38-6
Show/Hide
|
C17H23NO
|
1
|
| 1 |
IC50 = 4 nM
|
|
|
|
CP0409713
|
3-(2,5-Dimethoxy-phenyl)-1-[2-(3-hydroxy-pyrrolidin-1-yl)-1-phenyl-ethyl]-1H-pyridin-2-one
Show/Hide
|
C25H28N2O4
|
1
|
| 1 |
IC50 = 6.9 nM
|
|
|
|
CP0409099
|
1-[2-(3-Hydroxy-pyrrolidin-1-yl)-1-phenyl-ethyl]-3-(4-trifluoromethoxy-phenyl)-1H-pyridin-2-one
Show/Hide
|
C24H23F3N2O3
|
1
|
| 1 |
IC50 = 7.6 nM
|
|
|
|
CP0449080
|
3-(4-Fluoro-3-methyl-phenyl)-1-[2-(3-hydroxy-pyrrolidin-1-yl)-1-phenyl-ethyl]-1H-pyridin-2-one
Show/Hide
|
C24H25FN2O2
|
1
|
| 1 |
IC50 = 8.4 nM
|
|
|
|
CP0164875
|
1-(1-Phenyl-2-pyrrolidin-1-yl-ethyl)-3-(4-trifluoromethyl-phenyl)-1H-pyridin-2-one
Show/Hide
|
C24H23F3N2O
|
1
|
| 1 |
IC50 = 8.7 nM
|
|
|
|
CP0432431
|
3-(3-Hydroxymethyl-phenyl)-1-[2-(3-hydroxy-pyrrolidin-1-yl)-1-phenyl-ethyl]-1H-pyridin-2-one
Show/Hide
|
C24H26N2O3
|
1
|
| 1 |
IC50 = 9.6 nM
|
|
|
|
CP0463984
|
3-(2,6-Dimethoxy-phenyl)-1-[2-(3-hydroxy-pyrrolidin-1-yl)-1-phenyl-ethyl]-1H-pyridin-2-one
Show/Hide
|
C25H28N2O4
|
1
|
| 1 |
IC50 = 9.8 nM
|
|
|
|
CP0442010
|
2-{1-[2-(3-Hydroxy-pyrrolidin-1-yl)-1-phenyl-ethyl]-2-oxo-1,2-dihydro-pyridin-3-yl}-benzaldehyde
Show/Hide
|
C24H24N2O3
|
1
|
| 1 |
IC50 = 13 nM
|
|
|
|
CP0448087
|
3-(4-Acetyl-phenyl)-1-[2-(3-hydroxy-pyrrolidin-1-yl)-1-phenyl-ethyl]-1H-pyridin-2-one
Show/Hide
|
C25H26N2O3
|
1
|
| 1 |
IC50 = 14 nM
|
|
|
|
CP0857643
|
N-methyl-2-phenyl-N-((5R,7S,8S)-8-(pyrrolidin-1-yl)-1-oxaspiro[4.5]decan-7-yl)acetamide
Show/Hide
|
C22H32N2O2
|
2
|
| 1 |
IC50 = 16 nM
|
|
|
| 2 |
Ki = 6.4 nM
|
|
|
|
CP0288282
|
8-azabicyclo[3.2.1]octan-3-yloxy-benzamide
Show/Hide
|
C20H24N2O2S
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0462785
|
1-[2-(3-Hydroxy-pyrrolidin-1-yl)-1-phenyl-ethyl]-3-(3-trifluoromethoxy-phenyl)-1H-pyridin-2-one
Show/Hide
|
C24H23F3N2O3
|
1
|
| 1 |
IC50 = 22 nM
|
|
|
|
CP0472074
|
3-(3-Amino-phenyl)-1-[2-(3-hydroxy-pyrrolidin-1-yl)-1-phenyl-ethyl]-1H-pyridin-2-one
Show/Hide
|
C23H25N3O2
|
1
|
| 1 |
IC50 = 25 nM
|
|
|
|
CP0860286
|
4N,13N-dibenzyl-17-cyclopropylmethyl-16-methyl-17-azatetracyclo[7.6.2.02,7.010,15]heptadeca-2(7),3,5,12,14-pentaene-4,13-diamine
Show/Hide
|
C35H37N3
|
1
|
| 1 |
IC50 = 31 nM
|
|
|
|
CP0405225
|
3-(4-Fluoro-phenyl)-1-[2-(3-hydroxy-pyrrolidin-1-yl)-1-phenyl-ethyl]-1H-pyridin-2-one
Show/Hide
|
C23H23FN2O2
|
1
|
| 1 |
IC50 = 33 nM
|
|
|
|
CP0493904
|
3-(5-Acetyl-thiophen-2-yl)-1-[2-(3-hydroxy-pyrrolidin-1-yl)-1-phenyl-ethyl]-1H-pyridin-2-one
Show/Hide
|
C23H24N2O3S
|
1
|
| 1 |
IC50 = 38 nM
|
|
|
|
CP0866022
|
4-Methoxy-N-(1,2,3,4-tetrahydro-1-isoquinolinylmethyl)benzamide
Show/Hide
|
C18H20N2O2
|
1
|
| 1 |
IC50 = 50 nM
|
|
|
|
CP0404630
|
3-(5-Chloro-2-methoxy-phenyl)-1-[2-(3-hydroxy-pyrrolidin-1-yl)-1-phenyl-ethyl]-1H-pyridin-2-one
Show/Hide
|
C24H25ClN2O3
|
1
|
| 1 |
IC50 = 53 nM
|
|
|
|
CP0404629
|
6-{1-[2-Oxo-3-(4-trifluoromethyl-phenyl)-2H-pyridin-1-yl]-2-pyrrolidin-1-yl-ethyl}-4H-benzo[1,4]oxazin-3-one
Show/Hide
|
C26H24F3N3O3
|
1
|
| 1 |
IC50 = 57 nM
|
|
|
|
CP0483843
|
US9056836, 11
Show/Hide
|
C22H27NO5
|
1
|
| 1 |
IC50 = 66.82 nM
|
|
|
|
CP0868761
|
3,4-Dimethyl-N-[(2-methyl-1,2,3,4-tetrahydro-1-isoquinolinyl)methyl]benzamide
Show/Hide
|
C20H24N2O
|
1
|
| 1 |
IC50 = 80 nM
|
|
|
|
CP0461088
|
1-(1-Phenyl-2-pyrrolidin-1-yl-ethyl)-3-(4-trifluoromethyl-phenylamino)-1H-pyridin-2-one
Show/Hide
|
C24H24F3N3O
|
1
|
| 1 |
IC50 = 82 nM
|
|
|
|
CP0848863
|
4-Chloro-N-(1,2,3,4-tetrahydro-1-isoquinolinylmethyl)benzamide
Show/Hide
|
C17H17ClN2O
|
1
|
| 1 |
IC50 = 90 nM
|
|
|
|
CP0409712
|
1-(1-Phenyl-2-pyrrolidin-1-yl-ethyl)-3-p-tolylamino-1H-pyridin-2-one
Show/Hide
|
C24H27N3O
|
1
|
| 1 |
IC50 = 94 nM
|
|
|
|
CP0437232
|
1-[2-(3-Hydroxy-pyrrolidin-1-yl)-1-phenyl-ethyl]-3-(2-methoxy-phenyl)-1H-pyridin-2-one
Show/Hide
|
C24H26N2O3
|
1
|
| 1 |
IC50 = 94 nM
|
|
|
|
CP0431277
|
1'-cyclooctylmethyl-5-isopropyl-1-methylspiro[2,3-dihydro-1H-indole-3,4'-(hexahydropyridine)]-2-one
Show/Hide
|
C25H38N2O
|
1
|
| 1 |
IC50 = 97 nM
|
|
|
|
CP0378938
|
1'-cyclooctylmethyl-1-{2-hydroxy-3-[2-(1,4-oxazinan-4-yl)ethylamino]propyl}spiro[2,3-dihydro-1H-indole-3,4'-(hexahydropyridine)]-2-one
Show/Hide
|
C30H48N4O3
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0378192
|
1'-cyclooctylmethyl-6-hydroxy-1-methylspiro[2,3-dihydro-1H-indole-3,4'-(hexahydropyridine)]-2-one
Show/Hide
|
C22H32N2O2
|
1
|
| 1 |
IC50 = 120 nM
|
|
|
|
CP0858938
|
4-Methyl-N-[(2-methyl-1,2,3,4-tetrahydro-1-isoquinolinyl)methyl]benzamide
Show/Hide
|
C19H22N2O
|
1
|
| 1 |
IC50 = 140 nM
|
|
|
|
CP0906414
|
3-Methyl-N-(1,2,3,4-tetrahydro-1-isoquinolinylmethyl)benzamide
Show/Hide
|
C18H20N2O
|
1
|
| 1 |
IC50 = 140 nM
|
|
|
|
CP0350873
|
3-[[(1S,5R)-8-[2-[4-(dimethylcarbamoylamino)cyclohexyl]ethyl]-8-azabicyclo[3.2.1]octan-3-yl]oxy]benzamide
Show/Hide
|
C25H38N4O3
|
1
|
| 1 |
IC50 = 172 nM
|
|
|
|
CP0397806
|
8-(cyclooctylmethyl)-3-[(2S)-3-[2-(3,4-dimethoxyphenyl)ethylamino]-2-hydroxypropyl]-1-(4-fluorophenyl)-1,3,8-triazaspiro[4.5]decan-4-one
Show/Hide
|
C35H51FN4O4
|
1
|
| 1 |
IC50 = 200 nM
|
|
|
|
CP0857995
|
17-cyclopropylmethyl-16-methyl-17-azatetracyclo[7.6.2.02,7.010,15]heptadeca-2(7),3,5,12,14-pentaene-4,13-diol
Show/Hide
|
C21H23NO2
|
1
|
| 1 |
IC50 = 204 nM
|
|
|
|
CP0288283
|
3-((1R,3r,5S)-8-(cyclohexylmethyl)-8-azabicyclo[3.2.1]octan-3-yloxy)benzamide
Show/Hide
|
C21H30N2O2
|
1
|
| 1 |
IC50 = 204 nM
|
|
|
|
CP0378190
|
1'-cyclooctylmethyl-1-[3-ethyl(4-methylbenzyl)amino-2-hydroxypropyl]spiro[2,3-dihydro-1H-indole-3,4'-(hexahydropyridine)]-2-one
Show/Hide
|
C34H49N3O2
|
1
|
| 1 |
IC50 = 220 nM
|
|
|
|
CP0316361
|
3-[[(1S,5R)-8-benzyl-8-azabicyclo[3.2.1]octan-3-yl]oxy]-5-fluorobenzamide
Show/Hide
|
C21H23FN2O2
|
1
|
| 1 |
IC50 = 222 nM
|
|
|
|
CP0397802
|
3-[(2S)-3-[benzyl(butyl)amino]-2-hydroxypropyl]-8-(cyclooctylmethyl)-1-(4-fluorophenyl)-1,3,8-triazaspiro[4.5]decan-4-one
Show/Hide
|
C36H53FN4O2
|
1
|
| 1 |
IC50 = 240 nM
|
|
|
|
CP0431276
|
1'-cyclooctylmethyl-5-fluoro-1-methylspiro[2,3-dihydro-1H-indole-3,4'-(hexahydropyridine)]-2-one
Show/Hide
|
C22H31FN2O
|
1
|
| 1 |
IC50 = 250 nM
|
|
|
|
CP0848865
|
N-(1,2,3,4-tetrahydro-1-isoquinolinylmethyl)-4-(trifluoromethoxy)benzamide
Show/Hide
|
C18H17F3N2O2
|
1
|
| 1 |
IC50 = 260 nM
|
|
|
|
CP0354597
|
3-[[(1S,5R)-8-benzyl-8-azabicyclo[3.2.1]octan-3-yl]oxy]benzamide
Show/Hide
|
C21H24N2O2
|
1
|
| 1 |
IC50 = 286 nM
|
|
|
|
CP0432426
|
1-[1-(4-Methoxy-phenyl)-2-pyrrolidin-1-yl-ethyl]-3-(4-trifluoromethyl-phenyl)-1H-pyridin-2-one
Show/Hide
|
C25H25F3N2O2
|
1
|
| 1 |
IC50 = 320 nM
|
|
|
|
CP0453421
|
1-(1-Phenyl-2-pyrrolidin-1-yl-ethyl)-3-(1-p-tolyl-ethylamino)-1H-pyridin-2-one
Show/Hide
|
C26H31N3O
|
1
|
| 1 |
IC50 = 330 nM
|
|
|
|
CP0288284
|
CHEMBL1223954
Show/Hide
|
C21H24N2OS
|
1
|
| 1 |
IC50 = 338 nM
|
|
|
|
CP0293776
|
3-[[(1S,5R)-8-benzyl-8-azabicyclo[3.2.1]octan-3-yl]oxy]phenol
Show/Hide
|
C20H23NO2
|
1
|
| 1 |
IC50 = 347 nM
|
|
|
|
CP0553464
|
1-(2-bromo-4-methylphenyl)-3,6,6-trimethyl-5,7-dihydroindazol-4-one
Show/Hide
|
C17H19BrN2O
|
1
|
| 1 |
IC50 = 370 nM
|
|
|
|
CP0396914
|
1-(2,4-dibromophenyl)-3,6,6-trimethyl-5,7-dihydroindazol-4-one
Show/Hide
|
C16H16Br2N2O
|
1
|
| 1 |
IC50 = 410 nM
|
|
|
|
CP0375961
|
(3-{1-[2-Oxo-3-(4-trifluoromethyl-phenyl)-2H-pyridin-1-yl]-2-pyrrolidin-1-yl-ethyl}-phenoxy)-acetic acid
Show/Hide
|
C26H25F3N2O4
|
1
|
| 1 |
IC50 = 420 nM
|
|
|
|
CP0446480
|
1'-cyclooctylmethylspiro[2,3-dihydro-1H-indole-3,4'-(hexahydropyridine)]-2-one
Show/Hide
|
C21H30N2O
|
1
|
| 1 |
IC50 = 430 nM
|
|
|
|
CP0848864
|
3,4-Dichloro-N-[(2-methyl-1,2,3,4-tetrahydro-1-isoquinolinyl)methyl]benzamide
Show/Hide
|
C18H18Cl2N2O
|
1
|
| 1 |
IC50 = 440 nM
|
|
|
|
CP0269068
|
3-[[(1S,5R)-8-[2-[4-(dimethylcarbamoylamino)cyclohexyl]ethyl]-8-azabicyclo[3.2.1]octan-3-yl]oxy]benzamide
Show/Hide
|
C25H38N4O3
|
1
|
| 1 |
IC50 = 451 nM
|
|
|
|
CP0316364
|
4-[[(1R,5S)-8-benzyl-8-azabicyclo[3.2.1]octan-3-yl]oxy]-3-methylbenzamide
Show/Hide
|
C22H26N2O2
|
1
|
| 1 |
IC50 = 462 nM
|
|
|
|
CP0378189
|
1'-cyclooctylmethyl-1-(2-oxiranylmethyl)spiro[2,3-dihydro-1H-indole-3,4'-(hexahydropyridine)]-2-one
Show/Hide
|
C24H34N2O2
|
1
|
| 1 |
IC50 = 480 nM
|
|
|
|
CP0861339
|
4-Ethyl-N-[(2-methyl-1,2,3,4-tetrahydro-1-isoquinolinyl)methyl]benzamide
Show/Hide
|
C20H24N2O
|
1
|
| 1 |
IC50 = 490 nM
|
|
|
|
CP0448592
|
1'-cyclooctylmethyl-1,5-dimethylspiro[2,3-dihydro-1H-indole-3,4'-(hexahydropyridine)]-2-one
Show/Hide
|
C23H34N2O
|
1
|
| 1 |
IC50 = 540 nM
|
|
|
|
CP0403702
|
4-Phenyl-2-(1-phenyl-2-pyrrolidin-1-yl-ethyl)-2H-pyridazin-3-one
Show/Hide
|
C22H23N3O
|
1
|
| 1 |
IC50 = 550 nM
|
|
|
|
CP0431274
|
1'-cyclooctylmethyl-1,4-dimethylspiro[2,3-dihydro-1H-indole-3,4'-(hexahydropyridine)]-2-one
Show/Hide
|
C23H34N2O
|
1
|
| 1 |
IC50 = 560 nM
|
|
|
|
CP0396908
|
1-(2-bromo-4-chlorophenyl)-3,6,6-trimethyl-5,7-dihydroindazol-4-one
Show/Hide
|
C16H16BrClN2O
|
1
|
| 1 |
IC50 = 570 nM
|
|
|
|
CP0910261
|
4-Ethyl-N-(1,2,3,4-tetrahydro-1-isoquinolinylmethyl)benzamide
Show/Hide
|
C19H22N2O
|
1
|
| 1 |
IC50 = 570 nM
|
|
|
|
CP0240261
|
CHEMBL1223952
Show/Hide
|
C22H26N2O
|
1
|
| 1 |
IC50 = 596 nM
|
|
|
|
CP0442122
|
methyl 2-[1'-(cyclooctylmethyl)-2-oxospiro[indole-3,4'-piperidine]-1-yl]acetate
Show/Hide
|
C24H34N2O3
|
1
|
| 1 |
IC50 = 640 nM
|
|
|
|
CP0842136
|
4N,13N-dibenzyl-16,17-dimethyl-17-azatetracyclo[7.6.2.02,7.010,15]heptadeca-2(7),3,5,12,14-pentaene-4,13-diamine
Show/Hide
|
C32H33N3
|
1
|
| 1 |
IC50 = 640 nM
|
|
|
|
CP0498240
|
1-(2-Morpholin-4-yl-1-phenyl-ethyl)-3-(4-trifluoromethyl-phenyl)-1H-pyridin-2-one
Show/Hide
|
C24H23F3N2O2
|
1
|
| 1 |
IC50 = 700 nM
|
|
|
|
CP0861341
|
N-[(2-Butyl-1,2,3,4-tetrahydro-1-isoquinolinyl)methyl]-4-methylbenzamide
Show/Hide
|
C22H28N2O
|
1
|
| 1 |
IC50 = 780 nM
|
|
|
|
CP0893658
|
3,4-Dichloro-N-(1,2,3,4-tetrahydro-1-isoquinolinylmethyl)benzamide
Show/Hide
|
C17H16Cl2N2O
|
1
|
| 1 |
IC50 = 810 nM
|
|
|
|
CP0458883
|
N-(4-amino-2-methylquinolin-6-yl)-2-[[4-[(8-aminooctylamino)methyl]phenoxy]methyl]benzamide
Show/Hide
|
C33H41N5O2
|
1
|
| 1 |
IC50 = 872 nM
|
|
|
|
CP0467715
|
N-(4-amino-2-methylquinolin-6-yl)-2-[[4-[[10-[[4-[[2-[(4-amino-2-methylquinolin-6-yl)carbamoyl]phenyl]methoxy]phenyl]methylamino]decylamino]methyl]phenoxy]methyl]benzamide
Show/Hide
|
C60H66N8O4
|
1
|
| 1 |
IC50 = 900 nM
|
|
|
|
CP0378193
|
1'-cyclooctylmethyl-1-methylspiro[2,3-dihydro-1H-indole-3,4'-(hexahydropyridine)]-2-one
Show/Hide
|
C22H32N2O
|
1
|
| 1 |
IC50 = 930 nM
|
|
|
|
CP0849473
|
16,17-dimethyl-17-azatetracyclo[7.6.2.02,7.010,15]heptadeca-2(7),3,5,12,14-pentaene-4,13-diol
Show/Hide
|
C18H19NO2
|
1
|
| 1 |
IC50 = 961 nM
|
|
|
|
CP0467675
|
2-[[4-[(7-aminoheptylamino)methyl]phenoxy]methyl]-N-(4-amino-2-methylquinolin-6-yl)benzamide
Show/Hide
|
C32H39N5O2
|
1
|
| 1 |
IC50 = 998 nM
|
|
|
|
CP0473197
|
N-(4-amino-2-methylquinolin-6-yl)-2-[[4-[[7-[[4-[[2-[(4-amino-2-methylquinolin-6-yl)carbamoyl]phenyl]methoxy]phenyl]methylamino]heptylamino]methyl]phenoxy]methyl]benzamide
Show/Hide
|
C57H60N8O4
|
1
|
| 1 |
IC50 = 1023 nM
|
|
|
|
CP0438200
|
N-(4-amino-2-methylquinolin-6-yl)-2-[[4-[[9-[[4-[[2-[(4-amino-2-methylquinolin-6-yl)carbamoyl]phenyl]methoxy]phenyl]methylamino]nonylamino]methyl]phenoxy]methyl]benzamide
Show/Hide
|
C59H64N8O4
|
1
|
| 1 |
IC50 = 1049 nM
|
|
|
|
CP0458879
|
N-(4-amino-2-methylquinolin-6-yl)-2-[[4-[[4-[[4-[[2-[(4-amino-2-methylquinolin-6-yl)carbamoyl]phenyl]methoxy]phenyl]methylamino]butylamino]methyl]phenoxy]methyl]benzamide
Show/Hide
|
C54H54N8O4
|
1
|
| 1 |
IC50 = 1091 nM
|
|
|
|
CP0442124
|
1-benzyl-1'-cyclooctylmethylspiro[2,3-dihydro-1H-indole-3,4'-(hexahydropyridine)]-2-one
Show/Hide
|
C28H36N2O
|
1
|
| 1 |
IC50 = 1100 nM
|
|
|
|
CP0396913
|
1-(2,4-dibromophenyl)-3,6,6-trimethyl-5,7-dihydro-4H-indazol-4-ol
Show/Hide
|
C16H18Br2N2O
|
1
|
| 1 |
IC50 = 1100 nM
|
|
|
|
CP0861342
|
3-Chloro-N-(1,2,3,4-tetrahydro-1-isoquinolinylmethyl)benzamide
Show/Hide
|
C17H17ClN2O
|
1
|
| 1 |
IC50 = 1120 nM
|
|
|
|
CP0441164
|
N-(4-amino-2-methylquinolin-6-yl)-2-[[4-[(hexylamino)methyl]phenoxy]methyl]benzamide
Show/Hide
|
C31H36N4O2
|
1
|
| 1 |
IC50 = 1157 nM
|
|
|
|
CP0862931
|
4N,13N-diphenyl-17-cyclopropylmethyl-16-methyl-(9S,16R)-17-azatetracyclo[7.6.2.02,7.010,15]heptadeca-2(7),3,5,12,14-pentaene-4,13-diamine
Show/Hide
|
C33H33N3
|
1
|
| 1 |
IC50 = 1200 nM
|
|
|
|
CP0404849
|
1'-cyclooctylmethyl-6-methoxy-1-methylspiro[2,3-dihydro-1H-indole-3,4'-(hexahydropyridine)]-2-one
Show/Hide
|
C23H34N2O2
|
1
|
| 1 |
IC50 = 1220 nM
|
|
|
|
CP0436411
|
2-[[4-[(6-aminohexylamino)methyl]phenoxy]methyl]-N-(4-amino-2-methylquinolin-6-yl)benzamide
Show/Hide
|
C31H37N5O2
|
1
|
| 1 |
IC50 = 1222 nM
|
|
|
|
CP0464762
|
N-(4-amino-2-methylquinolin-6-yl)-2-[[4-[[8-[[4-[[2-[(4-amino-2-methylquinolin-6-yl)carbamoyl]phenyl]methoxy]phenyl]methylamino]octylamino]methyl]phenoxy]methyl]benzamide
Show/Hide
|
C58H62N8O4
|
1
|
| 1 |
IC50 = 1269 nM
|
|
|
|
CP0269067
|
3-[[(1S,5R)-8-[[4-(dimethylcarbamoylamino)cyclohexyl]methyl]-8-azabicyclo[3.2.1]octan-3-yl]oxy]benzamide
Show/Hide
|
C24H36N4O3
|
1
|
| 1 |
IC50 = 1301 nM
|
|
|
|
CP0460591
|
N-(4-amino-2-methylquinolin-6-yl)-2-[[4-[[6-[[4-[[2-[(4-amino-2-methylquinolin-6-yl)carbamoyl]phenyl]methoxy]phenyl]methylamino]hexylamino]methyl]phenoxy]methyl]benzamide
Show/Hide
|
C56H58N8O4
|
1
|
| 1 |
IC50 = 1347 nM
|
|
|
|
CP0402337
|
1-(2-[1,2]Diazepin-1-yl-1-phenyl-ethyl)-3-(4-trifluoromethyl-phenyl)-1H-pyridin-2-one
Show/Hide
|
C25H20F3N3O
|
1
|
| 1 |
IC50 = 1400 nM
|
|
|
|
CP0332308
|
3-[[(1S,5R)-8-benzyl-8-azabicyclo[3.2.1]octan-3-yl]amino]benzamide
Show/Hide
|
C21H25N3O
|
1
|
| 1 |
IC50 = 1489 nM
|
|
|
|
CP0477972
|
N-(4-amino-2-methylquinolin-6-yl)-2-[[4-[[5-[[4-[[2-[(4-amino-2-methylquinolin-6-yl)carbamoyl]phenyl]methoxy]phenyl]methylamino]pentylamino]methyl]phenoxy]methyl]benzamide
Show/Hide
|
C55H56N8O4
|
1
|
| 1 |
IC50 = 1496 nM
|
|
|
|
CP0894633
|
17-cyclopropylmethyl-16-methyl-4,13-di(4-methylhexahydro-1-pyrazinyl)-(16R)-17-azatetracyclo[7.6.2.02,7.010,15]heptadeca-2(7),3,5,12,14-pentaene
Show/Hide
|
C31H43N5
|
1
|
| 1 |
IC50 = 1600 nM
|
|
|
|
CP0458881
|
N-(4-amino-2-methylquinolin-6-yl)-2-[[4-[(3-aminopropylamino)methyl]phenoxy]methyl]benzamide
Show/Hide
|
C28H31N5O2
|
1
|
| 1 |
IC50 = 1649 nM
|
|
|
|
CP0000305
|
(-)-(etorphine)
Show/Hide
|
C17H19NO3
|
1
|
| 1 |
IC50 = 1705.1 nM
|
|
|
|
CP0496439
|
(1S,9R,16S)-16-benzyl-17-methyl-17-azatetracyclo[7.6.2.02,7.010,15]heptadeca-2,4,6,10,12,14-hexaene
Show/Hide
|
C24H23N
|
1
|
| 1 |
IC50 = 1710 nM
|
|
|
|
CP0315148
|
3-[[(1R,5S)-8-benzyl-8-azabicyclo[3.2.1]octan-3-yl]oxy]-5-methylbenzamide
Show/Hide
|
C22H26N2O2
|
1
|
| 1 |
IC50 = 1733 nM
|
|
|
|
CP0461301
|
5-Phenyl-3-(1-phenyl-2-pyrrolidin-1-yl-ethyl)-3H-pyrimidin-4-one
Show/Hide
|
C22H23N3O
|
1
|
| 1 |
IC50 = 1760 nM
|
|
|
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CP0464766
|
N-(4-amino-2-methylquinolin-6-yl)-2-[[4-[(heptylamino)methyl]phenoxy]methyl]benzamide
Show/Hide
|
C32H38N4O2
|
1
|
| 1 |
IC50 = 1850 nM
|
|
|
|
CP0898107
|
17-cyclopropylmethyl-16-methyl-13-methylcarbonyloxy-17-azatetracyclo[7.6.2.02,7.010,15]heptadeca-2(7),3,5,12,14-pentaen-4-yl acetate
Show/Hide
|
C25H27NO4
|
1
|
| 1 |
IC50 = 2020 nM
|
|
|
|
CP0135661
|
CHEMBL1223953
Show/Hide
|
C22H26N2O
|
1
|
| 1 |
IC50 = 2143 nM
|
|
|
|
CP0530026
|
N-(4-amino-2-methylquinolin-6-yl)-2-[[4-[(5-aminopentylamino)methyl]phenoxy]methyl]benzamide
Show/Hide
|
C30H35N5O2
|
1
|
| 1 |
IC50 = 2155 nM
|
|
|
|
CP0431273
|
1'-cyclooctylmethyl-1,6-dimethylspiro[2,3-dihydro-1H-indole-3,4'-(hexahydropyridine)]-2-one
Show/Hide
|
C23H34N2O
|
1
|
| 1 |
IC50 = 2380 nM
|
|
|
|
CP0453821
|
3-Phenyl-1-(1-phenyl-2-pyrrolidin-1-yl-ethyl)-1H-pyrazin-2-one
Show/Hide
|
C22H23N3O
|
1
|
| 1 |
IC50 = 2450 nM
|
|
|
|
CP0467714
|
N-(4-amino-2-methylquinolin-6-yl)-2-[[4-[(nonylamino)methyl]phenoxy]methyl]benzamide
Show/Hide
|
C34H42N4O2
|
1
|
| 1 |
IC50 = 2565 nM
|
|
|
|
CP0431272
|
2-[1'-cyclooctylmethyl-2-oxospiro[2,3-dihydro-1H-indole-3,4'-(hexahydropyridine)]-1-yl]ethyl acetate
Show/Hide
|
C25H36N2O3
|
1
|
| 1 |
IC50 = 2640 nM
|
|
|
|
CP0396910
|
1-(2,4-dichlorophenyl)-3,6,6-trimethyl-5,7-dihydroindazol-4-one
Show/Hide
|
C16H16Cl2N2O
|
1
|
| 1 |
IC50 = 2650 nM
|
|
|
|
CP0350878
|
4-[[(1R,5S)-8-benzyl-8-azabicyclo[3.2.1]octan-3-yl]oxy]-3-fluorobenzamide
Show/Hide
|
C21H23FN2O2
|
1
|
| 1 |
IC50 = 2698 nM
|
|
|
|
CP0866024
|
N-{[2-(2-Chloroethyl)-1,2,3,4-tetrahydro-1-isoquinolinyl]methyl}-4-methylbenzamide
Show/Hide
|
C20H23ClN2O
|
1
|
| 1 |
IC50 = 2940 nM
|
|
|
|
CP0429746
|
(1S,9R,16S)-17-methyl-16-(2-methylpropyl)-17-azatetracyclo[7.6.2.02,7.010,15]heptadeca-2,4,6,10,12,14-hexaene
Show/Hide
|
C21H25N
|
1
|
| 1 |
IC50 = 2970 nM
|
|
|
|
CP0458880
|
N-(4-amino-2-methylquinolin-6-yl)-2-[[4-(propylaminomethyl)phenoxy]methyl]benzamide
Show/Hide
|
C28H30N4O2
|
1
|
| 1 |
IC50 = 3079 nM
|
|
|
|
CP0439272
|
1-[1-(4-Diethylamino-phenyl)-2-pyrrolidin-1-yl-ethyl]-3-(4-trifluoromethyl-phenyl)-1H-pyridin-2-one
Show/Hide
|
C28H32F3N3O
|
1
|
| 1 |
IC50 = 3080 nM
|
|
|
|
CP0861136
|
16,17-dimethyl-4,13-di(4-methylhexahydro-1-pyrazinyl)-(16R)-17-azatetracyclo[7.6.2.02,7.010,15]heptadeca-2(7),3,5,12,14-pentaene
Show/Hide
|
C28H39N5
|
1
|
| 1 |
IC50 = 3200 nM
|
|
|
|
CP0405533
|
(1S,9R,16S)-17-methyl-16-propan-2-yl-17-azatetracyclo[7.6.2.02,7.010,15]heptadeca-2,4,6,10,12,14-hexaene
Show/Hide
|
C20H23N
|
1
|
| 1 |
IC50 = 3410 nM
|
|
|
|
CP0316362
|
3-[[(1R,5S)-8-benzyl-8-azabicyclo[3.2.1]octan-3-yl]oxy]-4-methylbenzamide
Show/Hide
|
C22H26N2O2
|
1
|
| 1 |
IC50 = 3500 nM
|
|
|
|
CP0912304
|
4N,13N-diphenyl-16,17-dimethyl-(16R)-17-azatetracyclo[7.6.2.02,7.010,15]heptadeca-2(7),3,5,12,14-pentaene-4,13-diamine
Show/Hide
|
C30H29N3
|
1
|
| 1 |
IC50 = 3600 nM
|
|
|
|
CP0460589
|
N-(4-amino-2-methylquinolin-6-yl)-2-[[4-[(pentylamino)methyl]phenoxy]methyl]benzamide
Show/Hide
|
C30H34N4O2
|
1
|
| 1 |
IC50 = 3669 nM
|
|
|
|
CP0378194
|
1'-cyclooctylmethyl-5-isopropyl-1-propylspiro[2,3-dihydro-1H-indole-3,4'-(hexahydropyridine)]-2-one
Show/Hide
|
C27H42N2O
|
1
|
| 1 |
IC50 = 4000 nM
|
|
|
|
CP0316363
|
3-[[(1R,5S)-8-benzyl-8-azabicyclo[3.2.1]octan-3-yl]oxy]-2-methylbenzamide
Show/Hide
|
C22H26N2O2
|
1
|
| 1 |
IC50 = 4176 nM
|
|
|
|
CP0269069
|
3-[[(1S,5R)-8-[[4-(dimethylcarbamoylamino)cyclohexyl]methyl]-8-azabicyclo[3.2.1]octan-3-yl]oxy]benzamide
Show/Hide
|
C24H36N4O3
|
1
|
| 1 |
IC50 = 4197 nM
|
|
|
|
CP0458882
|
2-[[4-[(4-aminobutylamino)methyl]phenoxy]methyl]-N-(4-amino-2-methylquinolin-6-yl)benzamide
Show/Hide
|
C29H33N5O2
|
1
|
| 1 |
IC50 = 4257 nM
|
|
|
|
CP0464761
|
N-(4-amino-2-methylquinolin-6-yl)-2-[[4-[(decylamino)methyl]phenoxy]methyl]benzamide
Show/Hide
|
C35H44N4O2
|
1
|
| 1 |
IC50 = 4348 nM
|
|
|
|
CP0464760
|
N-(4-amino-2-methylquinolin-6-yl)-2-[[4-[(octylamino)methyl]phenoxy]methyl]benzamide
Show/Hide
|
C33H40N4O2
|
1
|
| 1 |
IC50 = 4955 nM
|
|
|
|
CP0847518
|
17-cyclopropylmethyl-4,13-dimethoxy-16-methyl-17-azatetracyclo[7.6.2.02,7.010,15]heptadeca-2(7),3,5,12,14-pentaene
Show/Hide
|
C23H27NO2
|
1
|
| 1 |
IC50 = 5330 nM
|
|
|
|
CP0460590
|
N-(4-amino-2-methylquinolin-6-yl)-2-[[4-[[3-[[4-[[2-[(4-amino-2-methylquinolin-6-yl)carbamoyl]phenyl]methoxy]phenyl]methylamino]propylamino]methyl]phenoxy]methyl]benzamide
Show/Hide
|
C53H52N8O4
|
1
|
| 1 |
IC50 = 5475 nM
|
|
|
|
CP0471448
|
N-(4-amino-2-methylquinolin-6-yl)-2-[[4-(butylaminomethyl)phenoxy]methyl]benzamide
Show/Hide
|
C29H32N4O2
|
1
|
| 1 |
IC50 = 5924 nM
|
|
|
|
CP0860528
|
20-azapentacyclo[7.6.5.02,7.010,15.016,20]icosa-2(7),3,5,12,14-pentaene
Show/Hide
|
C19H19N
|
1
|
| 1 |
IC50 = 6100 nM
|
|
|
|
CP0505803
|
N-(4-amino-2-methylquinolin-6-yl)-2-[[4-[(9-aminononylamino)methyl]phenoxy]methyl]benzamide
Show/Hide
|
C34H43N5O2
|
1
|
| 1 |
IC50 = 6177 nM
|
|
|
|
CP0916131
|
4,13-dibromo-16,17-dimethyl-17-azatetracyclo[7.6.2.02,7.010,15]heptadeca-2(7),3,5,12,14-pentaene
Show/Hide
|
C18H17Br2N
|
1
|
| 1 |
IC50 = 6920 nM
|
|
|
|
CP0879674
|
4N,13N-di(4-bromobenzyl)-20-azapentacyclo[7.6.5.02,7.010,15.016,20]icosa-2(7),3,5,12,14-pentaene-4,13-diamine
Show/Hide
|
C33H31Br2N3
|
1
|
| 1 |
IC50 = 7000 nM
|
|
|
|
CP0857761
|
20-azapentacyclo[7.6.5.02,7.010,15.016,20]icosa-2(7),3,5,12,14-pentaene-4,13-diol
Show/Hide
|
C19H19NO2
|
1
|
| 1 |
IC50 = 7200 nM
|
|
|
|
CP0860291
|
21-azapentacyclo[7.6.6.02,7.010,15.016,21]henicosa-2(7),3,5,12,14-pentaene
Show/Hide
|
C20H21N
|
1
|
| 1 |
IC50 = 7400 nM
|
|
|
|
CP0887589
|
4,13-dibromo-20-azapentacyclo[7.6.5.02,7.010,15.016,20]icosa-2(7),3,5,12,14-pentaene
Show/Hide
|
C19H17Br2N
|
1
|
| 1 |
IC50 = 7400 nM
|
|
|
|
CP0124715
|
N-(4-amino-2-methylquinolin-6-yl)-2-[(4-ethylphenoxy)methyl]benzamide
Show/Hide
|
C26H25N3O2
|
1
|
| 1 |
IC50 = 7512 nM
|
|
|
|
CP0126522
|
3-[[(1R,5S)-8-benzyl-8-azabicyclo[3.2.1]octan-3-yl]sulfinyl]benzamide
Show/Hide
|
C21H24N2O2S
|
1
|
| 1 |
IC50 = 8242 nM
|
|
|
|
CP0288285
|
2-[[(1S,5R)-8-benzyl-8-azabicyclo[3.2.1]octan-3-yl]oxy]pyridine-4-carboxamide
Show/Hide
|
C20H23N3O2
|
1
|
| 1 |
IC50 = 8624 nM
|
|
|
|
CP0861340
|
3,4-Dimethyl-N-(1,2,3,4-tetrahydro-1-isoquinolinylmethyl)benzamide
Show/Hide
|
C19H22N2O
|
1
|
| 1 |
IC50 = 8930 nM
|
|
|
|
CP0464763
|
2-[[4-[(10-aminodecylamino)methyl]phenoxy]methyl]-N-(4-amino-2-methylquinolin-6-yl)benzamide
Show/Hide
|
C35H45N5O2
|
1
|
| 1 |
IC50 = 9103 nM
|
|
|
|
CP0194600
|
3-[[(1S,5R)-8-benzyl-8-azabicyclo[3.2.1]octan-3-yl]oxy]benzamide
Show/Hide
|
C21H24N2O2
|
1
|
| 1 |
IC50 = 9680 nM
|
|
|
|
CP0457255
|
1-(2-Imidazol-1-yl-1-phenyl-ethyl)-3-(4-trifluoromethyl-phenyl)-1H-pyridin-2-one
Show/Hide
|
C23H18F3N3O
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0378939
|
1'-cyclooctylmethyl-1-cyclopropylmethyl-6-methoxyspiro[2,3-dihydro-1H-indole-3,4'-(hexahydropyridine)]-2-one
Show/Hide
|
C26H38N2O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0483671
|
2-[1'-cyclooctylmethyl-2-oxospiro[2,3-dihydro-1H-indole-3,4'-(hexahydropyridine)]-1-yl]acetic acid
Show/Hide
|
C23H32N2O3
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0377742
|
(1S,9R,16R)-16-methyl-17-azatetracyclo[7.6.2.02,7.010,15]heptadeca-2,4,6,10,12,14-hexaene
Show/Hide
|
C17H17N
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0429531
|
3-[(1S,9R,16S)-17-methyl-17-azatetracyclo[7.6.2.02,7.010,15]heptadeca-2,4,6,10,12,14-hexaen-16-yl]propan-1-ol
Show/Hide
|
C20H23NO
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0440968
|
(1S,9R,16S)-16,17-dimethyl-17-azatetracyclo[7.6.2.02,7.010,15]heptadeca-2,4,6,10,12,14-hexaene
Show/Hide
|
C18H19N
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0846761
|
1-[16-methyl-17-azatetracyclo[7.6.2.02,7.010,15]heptadeca-2(7),3,5,12,14-pentaen-17-yl]-1-ethanone
Show/Hide
|
C19H19NO
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0860195
|
16-methyl-(16S)-17-azatetracyclo[7.6.2.02,7.010,15]heptadeca-2(7),3,5,12,14-pentaen-17-ylmethanol
Show/Hide
|
C18H19NO
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0860198
|
4,13-dimethoxy-16,17-dimethyl-17-azatetracyclo[7.6.2.02,7.010,15]heptadeca-2(7),3,5,12,14-pentaene
Show/Hide
|
C20H23NO2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0861137
|
17-cyclopropylmethyl-16-methyl-17-azatetracyclo[7.6.2.02,7.010,15]heptadeca-2(7),3,5,12,14-pentaene
Show/Hide
|
C21H23N
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0863316
|
4-[16,17-dimethyl-13-(1,4-oxazinan-4-yl)-17-azatetracyclo[7.6.2.02,7.010,15]heptadeca-2(7),3,5,12,14-pentaen-4-yl]-1,4-oxazinane
Show/Hide
|
C26H33N3O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0879677
|
4,5,12,13-tetramethoxy-16,17-dimethyl-17-azatetracyclo[7.6.2.02,7.010,15]heptadeca-2(7),3,5,12,14-pentaene
Show/Hide
|
C22H27NO4
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0879871
|
17-cyclopropylmethyl-4,5,12,13-tetramethoxy-16-methyl-17-azatetracyclo[7.6.2.02,7.010,15]heptadeca-2(7),3,5,12,14-pentaene
Show/Hide
|
C25H31NO4
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0894635
|
4,13-dimethoxy-20-azapentacyclo[7.6.5.02,7.010,15.016,20]icosa-2(7),3,5,12,14-pentaene
Show/Hide
|
C21H23NO2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0926227
|
4,5,13,14-tetramethoxy-16,17-dimethyl-17-azatetracyclo[7.6.2.02,7.010,15]heptadeca-2(7),3,5,12,14-pentaene
Show/Hide
|
C22H27NO4
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0135663
|
4-[[(1R,5S)-8-benzyl-8-azabicyclo[3.2.1]octan-3-yl]oxy]benzamide
Show/Hide
|
C21H24N2O2
|
1
|
| 1 |
IC50 = 10729 nM
|
|
|
|
CP0350876
|
4-[[(1S,5R)-8-benzyl-8-azabicyclo[3.2.1]octan-3-yl]oxy]pyridine-2-carboxamide
Show/Hide
|
C20H23N3O2
|
1
|
| 1 |
IC50 = 14161 nM
|
|
|
|
CP0079310
|
(-)-Codeine
Show/Hide
|
C18H21NO3
|
1
|
| 1 |
IC50 = 15000 nM
|
|
|
|
CP0269070
|
5-[[(1S,5R)-8-benzyl-8-azabicyclo[3.2.1]octan-3-yl]oxy]pyridine-3-carboxamide
Show/Hide
|
C20H23N3O2
|
1
|
| 1 |
IC50 = 17802 nM
|
|
|
|
CP0866030
|
4-Fluoro-N-(1,2,3,4-tetrahydro-1-isoquinolinylmethyl)benzamide
Show/Hide
|
C17H17FN2O
|
1
|
| 1 |
IC50 = 18600 nM
|
|
|
|
CP0269071
|
6-[[(1R,5S)-8-benzyl-8-azabicyclo[3.2.1]octan-3-yl]oxy]pyridine-3-carboxamide
Show/Hide
|
C20H23N3O2
|
1
|
| 1 |
IC50 = 19287 nM
|
|
|
|
CP0240262
|
3-[[(1R,5S)-8-benzyl-8-azabicyclo[3.2.1]octan-3-yl]oxy]-N-methylbenzamide
Show/Hide
|
C22H26N2O2
|
1
|
| 1 |
IC50 > 30000 nM
|
|
|
|
CP0288286
|
6-[[(1S,5R)-8-benzyl-8-azabicyclo[3.2.1]octan-3-yl]oxy]pyrazine-2-carboxamide
Show/Hide
|
C19H22N4O2
|
1
|
| 1 |
IC50 > 30000 nM
|
|
|
|
CP0288287
|
2-[[(1R,5S)-8-benzyl-8-azabicyclo[3.2.1]octan-3-yl]oxy]benzamide
Show/Hide
|
C21H24N2O2
|
1
|
| 1 |
IC50 > 30000 nM
|
|
|
|
CP0293775
|
6-[[(1S,5R)-8-benzyl-8-azabicyclo[3.2.1]octan-3-yl]oxy]pyridine-2-carboxamide
Show/Hide
|
C20H23N3O2
|
1
|
| 1 |
IC50 > 30000 nM
|
|
|
|
CP0350881
|
5-[[(1S,5R)-8-benzyl-8-azabicyclo[3.2.1]octan-3-yl]oxy]pyridine-2-carboxamide
Show/Hide
|
C20H23N3O2
|
1
|
| 1 |
IC50 > 30000 nM
|
|
|
|
CP0354598
|
3-[[(1S,5R)-8-benzyl-8-azabicyclo[3.2.1]octan-3-yl]oxy]-N,N-dimethylbenzamide
Show/Hide
|
C23H28N2O2
|
1
|
| 1 |
IC50 > 30000 nM
|
|
|
|
CP0916741
|
16,17-dimethyl-17-azatetracyclo[7.6.2.02,7.010,15]heptadeca-2(7),3,5,12,14-pentaene
Show/Hide
|
C18H19N
|
1
|
| 1 |
IC50 > 75000 nM
|
|
|
|
CP0402346
|
3-Phenylamino-1-(1-phenyl-2-pyrrolidin-1-yl-ethyl)-1H-pyridin-2-one
Show/Hide
|
C23H25N3O
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0846760
|
17-allyl-16-methyl-17-azatetracyclo[7.6.2.02,7.010,15]heptadeca-2(7),3,5,12,14-pentaene
Show/Hide
|
C20H21N
|
1
|
| 1 |
IC50 > 4000 nM
|
|
|
|
CP0900036
|
4,13-dibromo-17-cyclopropylmethyl-16-methyl-17-azatetracyclo[7.6.2.02,7.010,15]heptadeca-2(7),3,5,12,14-pentaene
Show/Hide
|
C21H21Br2N
|
1
|
| 1 |
IC50 > 4900 nM
|
|
|
|
CP0848432
|
16-methyl-17-azatetracyclo[7.6.2.02,7.010,15]heptadeca-2(7),3,5,12,14-pentaen-17-yl(phenyl)methane
Show/Hide
|
C24H23N
|
1
|
| 1 |
IC50 > 5800 nM
|
|
|
|
CP0894634
|
13-methylcarbonyloxy-20-azapentacyclo[7.6.5.02,7.010,15.016,20]icosa-2(7),3,5,12,14-pentaen-4-yl acetate
Show/Hide
|
C23H23NO4
|
1
|
| 1 |
IC50 > 6000 nM
|
|
|
|
CP0860157
|
4,13-difluoro-20-azapentacyclo[7.6.5.02,7.010,15.016,20]icosa-2(7),3,5,12,14-pentaene
Show/Hide
|
C19H17F2N
|
1
|
| 1 |
IC50 > 6400 nM
|
|
|
|
CP0861141
|
16,17-dimethyl-13-methylcarbonyloxy-17-azatetracyclo[7.6.2.02,7.010,15]heptadeca-2(7),3,5,12,14-pentaen-4-yl acetate
Show/Hide
|
C22H23NO4
|
1
|
| 1 |
IC50 > 9500 nM
|
|
|
|
CP0858120
|
2-[16-methyl-(16S)-17-azatetracyclo[7.6.2.02,7.010,15]heptadeca-2(7),3,5,12,14-pentaen-17-yl]-1-ethanol
Show/Hide
|
C19H21NO
|
1
|
| 1 |
IC50 > 9960 nM
|
|
|
|
CP0560037
|
US9221831, 75
Show/Hide
|
C32H38N2O5
|
1
|
| 1 |
Ki = 0.014 nM
|
|
|
|
CP0072629
|
2-[3-cyclopropylmethyl-11-hydroxy-15-methoxy-(1S,2R,6S,14R,15R,16R)-13-oxa-3-azahexacyclo[13.2.2.12,8.01,6.06,14.07,12]icosa-7,9,11-trien-16-yl]-2-propanol
Show/Hide
|
C26H35NO4
|
1
|
| 1 |
Ki = 0.02 nM
|
|
|
|
CP0561031
|
US9221831, 15
Show/Hide
|
C31H36FNO3
|
1
|
| 1 |
Ki = 0.02 nM
|
|
|
|
CP0484015
|
US9221831, 28
Show/Hide
|
C32H40N2O3
|
1
|
| 1 |
Ki = 0.04 nM
|
|
|
|
CP0072627
|
BUPRENORPHINE
Show/Hide
|
C29H41NO4
|
2
|
| 1 |
Ki = 0.04 nM
|
|
|
| 2 |
Ki = 0.07 nM
|
|
|
|
CP0048724
|
(4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-bis(oxidanyl)-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7-one;hydrochloride
Show/Hide
|
C20H23NO4
|
2
|
| 1 |
Ki = 0.042 nM
|
|
|
| 2 |
Ki = 0.81 nM
|
|
|
|
CP0572416
|
US9221831, 72
Show/Hide
|
C33H40N2O5
|
1
|
| 1 |
Ki = 0.05 nM
|
|
|
|
CP0400515
|
US8969358, 101
Show/Hide
|
C33H41N3O4
|
1
|
| 1 |
Ki = 0.06 nM
|
|
|
|
CP0578133
|
US8969358, 105
Show/Hide
|
C30H43N3O4
|
1
|
| 1 |
Ki = 0.06 nM
|
|
|
|
CP0519533
|
US9221831, 85
Show/Hide
|
C30H42N2O5
|
1
|
| 1 |
Ki = 0.06 nM
|
|
|
|
CP0454022
|
US8969358, 124
Show/Hide
|
C31H38N2O5S
|
1
|
| 1 |
Ki = 0.07 nM
|
|
|
|
CP0457077
|
US8969358, 112
Show/Hide
|
C26H35N3O4
|
1
|
| 1 |
Ki = 0.07 nM
|
|
|
|
CP0553850
|
US8969358, 106
Show/Hide
|
C29H39N3O4
|
1
|
| 1 |
Ki = 0.07 nM
|
|
|
|
CP0561353
|
US9221831, 84
Show/Hide
|
C33H40N2O5
|
1
|
| 1 |
Ki = 0.07 nM
|
|
|
|
CP0570657
|
US9221831, 69
Show/Hide
|
C32H36N2O3
|
1
|
| 1 |
Ki = 0.07 nM
|
|
|
|
CP0379341
|
(1R,2S,6R,14R,15S,19R)-15-(2-fluoroethoxy)-19-[(2S)-2-hydroxy-4-phenylbutan-2-yl]-5-methyl-13-oxa-5-azahexacyclo[13.2.2.12,8.01,6.02,14.012,20]icosa-8(20),9,11,16-tetraen-11-ol
Show/Hide
|
C31H36FNO4
|
1
|
| 1 |
Ki = 0.08 nM
|
|
|
|
CP0524305
|
US8969358, 136
Show/Hide
|
C31H37N3O4
|
1
|
| 1 |
Ki = 0.08 nM
|
|
|
|
CP0577839
|
US8969358, 125
Show/Hide
|
C30H36N2O5S
|
1
|
| 1 |
Ki = 0.08 nM
|
|
|
|
CP0522213
|
US9221831, 18
Show/Hide
|
C28H33NO4
|
1
|
| 1 |
Ki = 0.08 nM
|
|
|
|
CP0561032
|
US9221831, 22
Show/Hide
|
C27H31NO4
|
1
|
| 1 |
Ki = 0.08 nM
|
|
|
|
CP0400516
|
US8969358, 121
Show/Hide
|
C28H38N4O5
|
1
|
| 1 |
Ki = 0.09 nM
|
|
|
|
CP0561382
|
US8969358, 102
Show/Hide
|
C30H43N3O4
|
1
|
| 1 |
Ki = 0.09 nM
|
|
|
|
CP0066819
|
US8530494, 6
Show/Hide
|
C32H39NO4
|
1
|
| 1 |
Ki = 0.09 nM
|
|
|
|
CP0517845
|
US9221831, 11
Show/Hide
|
C33H37N3O4
|
1
|
| 1 |
Ki = 0.09 nM
|
|
|
|
CP0575555
|
US8969358, 137
Show/Hide
|
C32H39N3O4
|
1
|
| 1 |
Ki = 0.1 nM
|
|
|
|
CP0531274
|
US9221831, 76
Show/Hide
|
C32H38N2O4
|
1
|
| 1 |
Ki = 0.1 nM
|
|
|
|
CP0563216
|
US8969358, 123
Show/Hide
|
C33H39N3O4
|
1
|
| 1 |
Ki = 0.11 nM
|
|
|
|
CP0512640
|
US9221831, 91
Show/Hide
|
C33H41N3O5
|
1
|
| 1 |
Ki = 0.11 nM
|
|
|
|
CP0379340
|
(1S,2S,6R,14R,15R,16R)-5-(cyclopropylmethyl)-15-(2-fluoroethoxy)-16-[(2S)-2-hydroxy-3,3-dimethylbutan-2-yl]-13-oxa-5-azahexacyclo[13.2.2.12,8.01,6.02,14.012,20]icosa-8(20),9,11-trien-11-ol
Show/Hide
|
C30H42FNO4
|
1
|
| 1 |
Ki = 0.12 nM
|
|
|
|
CP0402715
|
US9315514, 3
Show/Hide
|
C29H39NO4
|
1
|
| 1 |
Ki = 0.12 nM
|
|
|
|
CP0551299
|
US8969358, 113
Show/Hide
|
C35H43N3O6
|
1
|
| 1 |
Ki = 0.13 nM
|
|
|
|
CP0563215
|
US8969358, 107
Show/Hide
|
C33H41N3O5
|
1
|
| 1 |
Ki = 0.13 nM
|
|
|
|
CP0506814
|
US8969358, 103
Show/Hide
|
C27H37N3O4
|
1
|
| 1 |
Ki = 0.14 nM
|
|
|
|
CP0523334
|
US9221831, 86
Show/Hide
|
C27H36N2O5
|
1
|
| 1 |
Ki = 0.14 nM
|
|
|
|
CP0525179
|
US9221831, 30
Show/Hide
|
C34H42N2O4
|
1
|
| 1 |
Ki = 0.14 nM
|
|
|
|
CP0561349
|
US9221831, 31
Show/Hide
|
C32H39NO3S
|
1
|
| 1 |
Ki = 0.14 nM
|
|
|
|
CP0518281
|
US9221831, 74
Show/Hide
|
C38H42N2O5
|
1
|
| 1 |
Ki = 0.15 nM
|
|
|
|
CP0518312
|
US9221831, 26
Show/Hide
|
C31H40N2O5
|
1
|
| 1 |
Ki = 0.15 nM
|
|
|
|
CP0557544
|
US9221831, 21
Show/Hide
|
C29H34N2O4
|
1
|
| 1 |
Ki = 0.15 nM
|
|
|
|
CP0506951
|
US8969358, 111
Show/Hide
|
C35H43N3O5
|
1
|
| 1 |
Ki = 0.16 nM
|
|
|
|
CP0541993
|
US8969358, 115
Show/Hide
|
C31H41N3O5
|
1
|
| 1 |
Ki = 0.16 nM
|
|
|
|
CP0464975
|
US8969358, 129
Show/Hide
|
C28H37N3O5
|
1
|
| 1 |
Ki = 0.17 nM
|
|
|
|
CP0539826
|
US8969358, 104
Show/Hide
|
C27H37N3O5
|
1
|
| 1 |
Ki = 0.18 nM
|
|
|
|
CP0899391
|
US9096606, 21
Show/Hide
|
C32H39ClNO4+
|
1
|
| 1 |
Ki = 0.19 nM
|
|
|
|
CP0491407
|
US9221831, 4
Show/Hide
|
C28H32FNO3
|
1
|
| 1 |
Ki = 0.19 nM
|
|
|
|
CP0518495
|
US9315514, 4
Show/Hide
|
C31H43NO4
|
1
|
| 1 |
Ki = 0.19 nM
|
|
|
|
CP0415677
|
(1S,2S,6R,14R,15S,16R)-5-(cyclopropylmethyl)-15-(2-fluoroethoxy)-16-(2-hydroxypropan-2-yl)-13-oxa-5-azahexacyclo[13.2.2.12,8.01,6.02,14.012,20]icosa-8(20),9,11-trien-11-ol
Show/Hide
|
C27H36FNO4
|
1
|
| 1 |
Ki = 0.2 nM
|
|
|
|
CP0955083
|
US9096606, 16
Show/Hide
|
C32H39FNO4+
|
1
|
| 1 |
Ki = 0.2 nM
|
|
|
|
CP0960055
|
US9096606, 15
Show/Hide
|
C30H38NO4S+
|
1
|
| 1 |
Ki = 0.2 nM
|
|
|
|
CP0546004
|
US9221831, 73
Show/Hide
|
C34H41NO7
|
1
|
| 1 |
Ki = 0.2 nM
|
|
|
|
CP0399863
|
US8969358, 117
Show/Hide
|
C28H37N3O5
|
1
|
| 1 |
Ki = 0.22 nM
|
|
|
|
CP0528995
|
US9221831, 3
Show/Hide
|
C30H35NO3
|
1
|
| 1 |
Ki = 0.23 nM
|
|
|
|
CP0512685
|
US9221831, 19
Show/Hide
|
C31H36BrNO3
|
1
|
| 1 |
Ki = 0.24 nM
|
|
|
|
CP0926450
|
US9096606, 19
Show/Hide
|
C32H39FNO4+
|
1
|
| 1 |
Ki = 0.25 nM
|
|
|
|
CP0956780
|
US8969358, 109
Show/Hide
|
C30H39N5O4
|
1
|
| 1 |
Ki = 0.25 nM
|
|
|
|
CP0935636
|
US9096606, 4
Show/Hide
|
C32H39FNO4+
|
1
|
| 1 |
Ki = 0.26 nM
|
|
|
|
CP0919317
|
US9096606, 20
Show/Hide
|
C32H39ClNO4+
|
1
|
| 1 |
Ki = 0.27 nM
|
|
|
|
CP0518309
|
US9221831, 2
Show/Hide
|
C28H34N2O3
|
1
|
| 1 |
Ki = 0.28 nM
|
|
|
|
CP0906696
|
US9096606, 11
Show/Hide
|
C30H38NO5+
|
1
|
| 1 |
Ki = 0.29 nM
|
|
|
|
CP0965842
|
US9096606, 17
Show/Hide
|
C33H42NO4+
|
1
|
| 1 |
Ki = 0.29 nM
|
|
|
|
CP0478256
|
US9221831, 61
Show/Hide
|
C33H40N2O5
|
1
|
| 1 |
Ki = 0.29 nM
|
|
|
|
CP0506815
|
US8969358, 134
Show/Hide
|
C32H36N2O6
|
1
|
| 1 |
Ki = 0.32 nM
|
|
|
|
CP0465830
|
US9388162, 73
Show/Hide
|
C23H31NO2
|
1
|
| 1 |
Ki = 0.32 nM
|
|
|
|
CP0479756
|
US9388162, 74
Show/Hide
|
C23H31NO2
|
1
|
| 1 |
Ki = 0.33 nM
|
|
|
|
CP0524414
|
US8969358, 110
Show/Hide
|
C29H39N3O5
|
1
|
| 1 |
Ki = 0.35 nM
|
|
|
|
CP0557530
|
US8969358, 120
Show/Hide
|
C32H45N3O5
|
1
|
| 1 |
Ki = 0.35 nM
|
|
|
|
CP0553851
|
US8969358, 126
Show/Hide
|
C25H31F3N2O5S
|
1
|
| 1 |
Ki = 0.37 nM
|
|
|
|
CP0457078
|
US8969358, 114
Show/Hide
|
C32H45N3O5
|
1
|
| 1 |
Ki = 0.4 nM
|
|
|
|
CP0530384
|
US9221831, 29
Show/Hide
|
C33H42N2O5S
|
1
|
| 1 |
Ki = 0.43 nM
|
|
|
|
CP0531271
|
US9221831, 32
Show/Hide
|
C32H39NO4S
|
1
|
| 1 |
Ki = 0.43 nM
|
|
|
|
CP0536940
|
US9315514, 11
Show/Hide
|
C29H37NO4
|
1
|
| 1 |
Ki = 0.44 nM
|
|
|
|
CP0567029
|
US9221831, 1
Show/Hide
|
C31H39NO5
|
1
|
| 1 |
Ki = 0.46 nM
|
|
|
|
CP0952676
|
US9096606, 22
Show/Hide
|
C33H42NO4+
|
1
|
| 1 |
Ki = 0.47 nM
|
|
|
|
CP0400517
|
US8969358, 131
Show/Hide
|
C30H41N3O5
|
1
|
| 1 |
Ki = 0.47 nM
|
|
|
|
CP0464976
|
US8969358, 133
Show/Hide
|
C30H35N5O5
|
1
|
| 1 |
Ki = 0.48 nM
|
|
|
|
CP0406826
|
US9221831, 16
Show/Hide
|
C29H36N2O5S
|
1
|
| 1 |
Ki = 0.53 nM
|
|
|
|
CP0965840
|
US9096606, 7
Show/Hide
|
C32H40NO4+
|
1
|
| 1 |
Ki = 0.55 nM
|
|
|
|
CP0899390
|
US9096606, 14
Show/Hide
|
C32H39ClNO4+
|
1
|
| 1 |
Ki = 0.59 nM
|
|
|
|
CP0550486
|
US8969358, 122
Show/Hide
|
C29H39N3O6
|
1
|
| 1 |
Ki = 0.61 nM
|
|
|
|
CP0536188
|
US8969358, 119
Show/Hide
|
C30H40N4O6
|
1
|
| 1 |
Ki = 0.62 nM
|
|
|
|
CP0564405
|
US9221831, 64
Show/Hide
|
C33H42N2O6S
|
1
|
| 1 |
Ki = 0.7 nM
|
|
|
|
CP0567724
|
US9315514, 5
Show/Hide
|
C32H45NO4
|
1
|
| 1 |
Ki = 0.72 nM
|
|
|
|
CP0519117
|
US9221831, 80
Show/Hide
|
C31H44N2O5
|
1
|
| 1 |
Ki = 0.73 nM
|
|
|
|
CP0464974
|
US8969358, 127
Show/Hide
|
C25H34N2O5S
|
1
|
| 1 |
Ki = 0.74 nM
|
|
|
|
CP0881219
|
US9096606, 5
Show/Hide
|
C34H40NO4S+
|
1
|
| 1 |
Ki = 0.78 nM
|
|
|
|
CP0478258
|
US9221831, 65
Show/Hide
|
C34H43NO4
|
1
|
| 1 |
Ki = 0.93 nM
|
|
|
|
CP0897879
|
US8969358, 116
Show/Hide
|
C32H41N5O5
|
1
|
| 1 |
Ki = 0.95 nM
|
|
|
|
CP0483039
|
US9388162, 9
Show/Hide
|
C22H27NO5
|
1
|
| 1 |
Ki = 0.97 nM
|
|
|
|
CP0531647
|
US9221831, 79
Show/Hide
|
C29H40N2O6
|
1
|
| 1 |
Ki = 1.02 nM
|
|
|
|
CP0055599
|
(4R,4aS,7aS,12bS)-3-(cyclopropylmethyl)-7-methylidene-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-4a,9-diol
Show/Hide
|
C21H25NO3
|
1
|
| 1 |
Ki = 1.03 nM
|
|
|
|
CP0881759
|
US9096606, 6
Show/Hide
|
C33H42NO4+
|
1
|
| 1 |
Ki = 1.06 nM
|
|
|
|
CP0556896
|
US9221831, 51
Show/Hide
|
C37H41NO3
|
1
|
| 1 |
Ki = 1.07 nM
|
|
|
|
CP0390636
|
(2E)-1-[6-[[2-[[2-[3-[[amino-[[(1S,2S,13R,21R)-22-(cyclopropylmethyl)-2,16-dihydroxy-14-oxa-11,22-diazaheptacyclo[13.9.1.01,13.02,21.04,12.05,10.019,25]pentacosa-4(12),5(10),6,8,15,17,19(25)-heptaen-7-yl]amino]methylidene]amino]propylamino]-2-oxoethyl]amino]-2-oxoethyl]amino]-6-oxohexyl]-3,3-dimethyl-2-[(2E,4E)-5-(1,3,3-trimethyl-5-sulfoindol-1-ium-2-yl)penta-2,4-dienylidene]indole-5-sulfonate
Show/Hide
|
C66H78N10O12S2
|
1
|
| 1 |
Ki = 1.1 nM
|
|
|
|
CP0423896
|
US9221831, 90
Show/Hide
|
C33H39NO7
|
1
|
| 1 |
Ki = 1.11 nM
|
|
|
|
CP0945584
|
US8969358, 135
Show/Hide
|
C28H36N6O4
|
1
|
| 1 |
Ki = 1.15 nM
|
|
|
|
CP0517848
|
US9221831, 82
Show/Hide
|
C31H44N2O5
|
1
|
| 1 |
Ki = 1.16 nM
|
|
|
|
CP0038839
|
(4R,4aS,7aR,12bS)-3-allyl-4a,9-dihydroxy-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7-one;hydrochloride
Show/Hide
|
C19H21NO4
|
4
|
| 1 |
Ki = 1.2 nM
|
|
|
| 2 |
Ki = 14.7 nM
|
|
|
| 3 |
Ki = 15 nM
|
|
|
| 4 |
Ki = 362 nM
|
|
|
|
CP0208977
|
N-(cyclohexylmethyl)-2,2-dimethyl-3-(methylamino)-3-phenylpropanamide
Show/Hide
|
C19H30N2O
|
1
|
| 1 |
Ki = 1.2 nM
|
|
|
|
CP0356608
|
3-(3-Hydroxy-phenyl)-2,2-dimethyl-3-methylamino-N-naphthalen-1-ylmethyl-propionamide
Show/Hide
|
C23H26N2O2
|
1
|
| 1 |
Ki = 1.3 nM
|
|
|
|
CP0561352
|
US9221831, 48
Show/Hide
|
C33H41N3O5
|
1
|
| 1 |
Ki = 1.37 nM
|
|
|
|
CP0560035
|
US9221831, 67
Show/Hide
|
C32H39NO5S
|
1
|
| 1 |
Ki = 1.39 nM
|
|
|
|
CP0391391
|
(2E)-1-[6-[3-[[amino-[[(1S,2S,13R,21R)-22-(cyclopropylmethyl)-2,16-dihydroxy-14-oxa-11,22-diazaheptacyclo[13.9.1.01,13.02,21.04,12.05,10.019,25]pentacosa-4(12),5(10),6,8,15,17,19(25)-heptaen-7-yl]amino]methylidene]amino]propylamino]-6-oxohexyl]-3,3-dimethyl-2-[(2E,4E)-5-(1,3,3-trimethyl-5-sulfoindol-1-ium-2-yl)penta-2,4-dienylidene]indole-5-sulfonate
Show/Hide
|
C62H72N8O10S2
|
1
|
| 1 |
Ki = 1.4 nM
|
|
|
|
CP0519116
|
US9221831, 68
Show/Hide
|
C28H39NO6
|
1
|
| 1 |
Ki = 1.57 nM
|
|
|
|
CP0531273
|
US9221831, 71
Show/Hide
|
C32H37NO5
|
1
|
| 1 |
Ki = 1.58 nM
|
|
|
|
CP0561351
|
US9221831, 41
Show/Hide
|
C31H38N2O5
|
1
|
| 1 |
Ki = 1.71 nM
|
|
|
|
CP0557542
|
US9221831, 20
Show/Hide
|
C29H32N2O3
|
1
|
| 1 |
Ki = 1.76 nM
|
|
|
|
CP0390637
|
(2E)-1-[6-[[2-[[2-[[2-[[2-[3-[[amino-[[(1S,2S,13R,21R)-22-(cyclopropylmethyl)-2,16-dihydroxy-14-oxa-11,22-diazaheptacyclo[13.9.1.01,13.02,21.04,12.05,10.019,25]pentacosa-4(12),5(10),6,8,15,17,19(25)-heptaen-7-yl]amino]methylidene]amino]propylamino]-2-oxoethyl]amino]-2-oxoethyl]amino]-2-oxoethyl]amino]-2-oxoethyl]amino]-6-oxohexyl]-3,3-dimethyl-2-[(2E,4E)-5-(1,3,3-trimethyl-5-sulfoindol-1-ium-2-yl)penta-2,4-dienylidene]indole-5-sulfonate
Show/Hide
|
C70H84N12O14S2
|
1
|
| 1 |
Ki = 1.8 nM
|
|
|
|
CP0518310
|
US9221831, 14
Show/Hide
|
C27H33N3O3S2
|
1
|
| 1 |
Ki = 2.43 nM
|
|
|
|
CP0568160
|
US9221831, 25
Show/Hide
|
C35H41NO5S
|
1
|
| 1 |
Ki = 2.51 nM
|
|
|
|
CP0525185
|
US9221831, 92
Show/Hide
|
C37H47NO6
|
1
|
| 1 |
Ki = 2.55 nM
|
|
|
|
CP0567030
|
US9221831, 35
Show/Hide
|
C38H51NO7
|
1
|
| 1 |
Ki = 2.55 nM
|
|
|
|
CP0536189
|
US8969358, 128
Show/Hide
|
C28H36N2O6
|
1
|
| 1 |
Ki = 2.62 nM
|
|
|
|
CP0512641
|
US9221831, 97
Show/Hide
|
C34H43NO6
|
1
|
| 1 |
Ki = 2.75 nM
|
|
|
|
CP0515110
|
US9221831, 47
Show/Hide
|
C33H41NO5
|
1
|
| 1 |
Ki = 2.76 nM
|
|
|
|
CP0556366
|
US9221831, 66
Show/Hide
|
C33H41N3O4
|
1
|
| 1 |
Ki = 2.86 nM
|
|
|
|
CP0291585
|
3-(Cyclopropylmethyl-methyl-amino)-3-(3-hydroxy-phenyl)-2,2-dimethyl-N-phenethyl-propionamide
Show/Hide
|
C24H32N2O2
|
1
|
| 1 |
Ki = 2.9 nM
|
|
|
|
CP0529251
|
US8969358, 108
Show/Hide
|
C28H37N3O6
|
1
|
| 1 |
Ki = 3.05 nM
|
|
|
|
CP0396991
|
(2E)-1-[6-[[2-[[2-[[2-[[2-[3-[[amino-[[(1S,2S,13R,21R)-22-(cyclopropylmethyl)-2,16-dihydroxy-14-oxa-11,22-diazaheptacyclo[13.9.1.01,13.02,21.04,12.05,10.019,25]pentacosa-4(12),5(10),6,8,15,17,19(25)-heptaen-7-yl]amino]methylidene]amino]propylamino]-2-oxoethyl]amino]-2-oxoethyl]amino]-2-oxoethyl]amino]-2-oxoethyl]amino]-6-oxohexyl]-3,3-dimethyl-2-[(E)-3-(1,3,3-trimethyl-5-sulfoindol-1-ium-2-yl)prop-2-enylidene]indole-5-sulfonate
Show/Hide
|
C68H82N12O14S2
|
1
|
| 1 |
Ki = 3.2 nM
|
|
|
|
CP0331945
|
3-(3-Hydroxy-phenyl)-2,2-dimethyl-3-methylamino-N-(3-phenyl-propyl)-propionamide
Show/Hide
|
C21H28N2O2
|
1
|
| 1 |
Ki = 3.6 nM
|
|
|
|
CP0532562
|
US9221831, 8
Show/Hide
|
C30H33N3O4
|
1
|
| 1 |
Ki = 4.18 nM
|
|
|
|
CP0530385
|
US9221831, 49
Show/Hide
|
C34H42N2O5
|
1
|
| 1 |
Ki = 4.39 nM
|
|
|
|
CP0561587
|
US9315514, 6
Show/Hide
|
C35H43NO4
|
1
|
| 1 |
Ki = 4.61 nM
|
|
|
|
CP0389013
|
(2S)-2-amino-N-[(4-anilino-1-benzylpiperidin-4-yl)methyl]-5-(diaminomethylideneamino)pentanamide
Show/Hide
|
C25H37N7O
|
1
|
| 1 |
Ki = 4.83 nM
|
|
|
|
CP0055256
|
N-benzyl-3-(3-hydroxyphenyl)-2,2-dimethyl-3-(methylamino)propanamide
Show/Hide
|
C19H24N2O2
|
1
|
| 1 |
Ki = 5 nM
|
|
|
|
CP0955002
|
US9096606, 1
Show/Hide
|
C33H40Cl2NO4+
|
1
|
| 1 |
Ki = 5.02 nM
|
|
|
|
CP0963832
|
US9221831, 70
Show/Hide
|
C32H37N5O3
|
1
|
| 1 |
Ki = 5.02 nM
|
|
|
|
CP0427873
|
8-indan-1-yl-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
|
C22H25N3O
|
1
|
| 1 |
Ki = 5.3 nM
|
|
|
|
CP0561348
|
US9221831, 23
Show/Hide
|
C29H33NO5
|
1
|
| 1 |
Ki = 5.49 nM
|
|
|
|
CP0462059
|
3-Methyl-1-phenethyl-4-(phenyl-propionyl-amino)-piperidine-4-carboxylic acid methyl ester
Show/Hide
|
C25H32N2O3
|
1
|
| 1 |
Ki = 5.5 nM
|
|
|
|
CP0219118
|
N-(cyclohexylmethyl)-3-(3-hydroxyphenyl)-2,2-dimethyl-3-(methylamino)propanamide
Show/Hide
|
C19H30N2O2
|
1
|
| 1 |
Ki = 5.7 nM
|
|
|
|
CP0557545
|
US9221831, 24
Show/Hide
|
C28H36N2O5
|
1
|
| 1 |
Ki = 5.74 nM
|
|
|
|
CP0246056
|
3-(3-Hydroxy-phenyl)-2,2-dimethyl-3-methylamino-N-phenethyl-propionamide
Show/Hide
|
C20H26N2O2
|
1
|
| 1 |
Ki = 6.3 nM
|
|
|
|
CP0531275
|
US9221831, 77
Show/Hide
|
C28H38N2O5
|
1
|
| 1 |
Ki = 6.63 nM
|
|
|
|
CP0562458
|
US9221831, 27
Show/Hide
|
C31H38N2O3
|
1
|
| 1 |
Ki = 6.69 nM
|
|
|
|
CP0572321
|
US9221831, 88
Show/Hide
|
C34H40N2O4
|
1
|
| 1 |
Ki = 6.75 nM
|
|
|
|
CP0555368
|
US8969358, 118
Show/Hide
|
C30H39N3O7
|
1
|
| 1 |
Ki = 7.1 nM
|
|
|
|
CP0516743
|
US9290488, ZA05
Show/Hide
|
C32H45N5O3
|
1
|
| 1 |
Ki = 7.4 nM
|
|
|
|
CP0529949
|
US9221831, 7
Show/Hide
|
C32H36N2O3S2
|
1
|
| 1 |
Ki = 8.03 nM
|
|
|
|
CP0567041
|
US9221831, 87
Show/Hide
|
C37H47NO6
|
1
|
| 1 |
Ki = 8.33 nM
|
|
|
|
CP0390635
|
(2E)-1-[6-[3-[[amino-[[(1S,2S,13R,21R)-22-(cyclopropylmethyl)-2,16-dihydroxy-14-oxa-11,22-diazaheptacyclo[13.9.1.01,13.02,21.04,12.05,10.019,25]pentacosa-4(12),5(10),6,8,15,17,19(25)-heptaen-7-yl]amino]methylidene]amino]propylamino]-6-oxohexyl]-3,3-dimethyl-2-[(E)-3-(1,3,3-trimethyl-5-sulfoindol-1-ium-2-yl)prop-2-enylidene]indole-5-sulfonate
Show/Hide
|
C60H70N8O10S2
|
1
|
| 1 |
Ki = 8.6 nM
|
|
|
|
CP0561021
|
US9221831, 50
Show/Hide
|
C34H42N2O6
|
1
|
| 1 |
Ki = 9.8 nM
|
|
|
|
CP0572320
|
US9221831, 63
Show/Hide
|
C34H43NO5
|
1
|
| 1 |
Ki = 10.06 nM
|
|
|
|
CP0539806
|
US9221831, 36
Show/Hide
|
C42H59NO9
|
1
|
| 1 |
Ki = 10.13 nM
|
|
|
|
CP0954972
|
US9096606, 24
Show/Hide
|
C31H40NO5+
|
1
|
| 1 |
Ki = 10.57 nM
|
|
|
|
CP0384913
|
1-Phenyl-8-(1,2,3,4-tetrahydro-naphthalen-1-yl)-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
|
C23H27N3O
|
1
|
| 1 |
Ki = 10.7 nM
|
|
|
|
CP0451938
|
US9290488, ZA04
Show/Hide
|
C30H41N5O3
|
1
|
| 1 |
Ki = 11.6 nM
|
|
|
|
CP0539807
|
US9221831, 39
Show/Hide
|
C35H43NO7
|
1
|
| 1 |
Ki = 12.07 nM
|
|
|
|
CP0567040
|
US9221831, 83
Show/Hide
|
C30H41N3O6
|
1
|
| 1 |
Ki = 12.67 nM
|
|
|
|
CP0412499
|
US9175000, 6
Show/Hide
|
C34H43NO6
|
1
|
| 1 |
Ki = 12.89 nM
|
|
|
|
CP0536237
|
US8969358, 130
Show/Hide
|
C30H40N2O6
|
1
|
| 1 |
Ki = 13.52 nM
|
|
|
|
CP0531276
|
US8969358, 100
Show/Hide
|
C28H39N3O4
|
1
|
| 1 |
Ki = 13.8 nM
|
|
|
|
CP0383583
|
US8846929, 101
Show/Hide
|
C27H39N5O
|
1
|
| 1 |
Ki = 14.9 nM
|
|
|
|
CP0546001
|
US9221831, 9
Show/Hide
|
C28H35N3O3S2
|
1
|
| 1 |
Ki = 15.02 nM
|
|
|
|
CP0441927
|
US8846929, 12
Show/Hide
|
C28H41N5O
|
1
|
| 1 |
Ki = 15.1 nM
|
|
|
|
CP0518311
|
US9221831, 17
Show/Hide
|
C30H36N2O4
|
1
|
| 1 |
Ki = 15.18 nM
|
|
|
|
CP0400518
|
US8969358, 132
Show/Hide
|
C30H34N4O6
|
1
|
| 1 |
Ki = 15.28 nM
|
|
|
|
CP0561497
|
US9221831, 44
Show/Hide
|
C27H37N3O4
|
1
|
| 1 |
Ki = 15.81 nM
|
|
|
|
CP0570656
|
US9221831, 58
Show/Hide
|
C30H36N2O5
|
1
|
| 1 |
Ki = 16.03 nM
|
|
|
|
CP0484017
|
US9221831, 55
Show/Hide
|
C29H38N2O5
|
1
|
| 1 |
Ki = 16.18 nM
|
|
|
|
CP0443713
|
US8846929, 326
Show/Hide
|
C35H51N5O5
|
1
|
| 1 |
Ki = 16.2 nM
|
|
|
|
CP0556385
|
US9090618, H56b(ii)
Show/Hide
|
C32H46N4O2
|
1
|
| 1 |
Ki = 16.3 nM
|
|
|
|
CP0392868
|
8-(8-Chloro-1,2,3,4-tetrahydro-naphthalen-2-yl)-3-(2-hydroxy-ethyl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
|
C25H30ClN3O2
|
1
|
| 1 |
Ki = 16.4 nM
|
|
|
|
CP0404575
|
8-(7-Chloro-1,2,3,4-tetrahydro-naphthalen-2-yl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
|
C23H26ClN3O
|
1
|
| 1 |
Ki = 16.4 nM
|
|
|
|
CP0501250
|
8-(5,8-Dichloro-1,2,3,4-tetrahydro-naphthalen-2-yl)-3-methyl-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
|
C24H27Cl2N3O
|
1
|
| 1 |
Ki = 17 nM
|
|
|
|
CP0537913
|
1-Phenyl-8-(1,2,3,4-tetrahydro-naphthalen-1-yl)-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
|
C23H27N3O
|
1
|
| 1 |
Ki = 17 nM
|
|
|
|
CP0904690
|
US9096606, 12
Show/Hide
|
C35H42NO5+
|
1
|
| 1 |
Ki = 17.31 nM
|
|
|
|
CP0492825
|
8-(8-Chloro-1,2,3,4-tetrahydro-naphthalen-2-yl)-3-methoxymethyl-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
|
C25H30ClN3O2
|
1
|
| 1 |
Ki = 17.5 nM
|
|
|
|
CP0523335
|
US9221831, 89
Show/Hide
|
C35H43NO6
|
1
|
| 1 |
Ki = 19.26 nM
|
|
|
|
CP0572319
|
US9221831, 59
Show/Hide
|
C33H39NO6
|
1
|
| 1 |
Ki = 19.8 nM
|
|
|
|
CP0531272
|
US9221831, 45
Show/Hide
|
C27H36N2O5
|
1
|
| 1 |
Ki = 20.48 nM
|
|
|
|
CP0503758
|
US8846929, 354
Show/Hide
|
C30H39N3O3
|
1
|
| 1 |
Ki = 20.6 nM
|
|
|
|
CP0517847
|
US9221831, 62
Show/Hide
|
C34H44N2O8S2
|
1
|
| 1 |
Ki = 20.61 nM
|
|
|
|
CP0393640
|
8-(5-Chloro-1,2,3,4-tetrahydro-naphthalen-2-yl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
|
C23H26ClN3O
|
1
|
| 1 |
Ki = 20.7 nM
|
|
|
|
CP0545613
|
US9175000, 16
Show/Hide
|
C39H45N3O4
|
1
|
| 1 |
Ki = 21.82 nM
|
|
|
|
CP0558145
|
(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[3-[(4S)-4-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-oxo-4,5-dihydro-1H-2-benzazepin-2-yl]propanoylamino]-5-carbamimidamidopentanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-carbamimidamidopentanamide
Show/Hide
|
C79H110N24O13
|
1
|
| 1 |
Ki = 22 nM
|
|
|
|
CP0503755
|
US8846929, 51
Show/Hide
|
C25H37N5O
|
1
|
| 1 |
Ki = 22 nM
|
|
|
|
CP0520563
|
US8846929, 5
Show/Hide
|
C27H39N5O
|
1
|
| 1 |
Ki = 22.5 nM
|
|
|
|
CP0524296
|
US8846929, 72
Show/Hide
|
C33H47N5O4
|
1
|
| 1 |
Ki = 23.4 nM
|
|
|
|
CP0561856
|
US8846929, 212
Show/Hide
|
C27H37N5O2
|
1
|
| 1 |
Ki = 25.9 nM
|
|
|
|
CP0274703
|
8-Acenaphthen-1-yl-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
|
C25H25N3O
|
1
|
| 1 |
Ki = 26 nM
|
|
|
|
CP0414922
|
3-Allyl-8-(5,8-dichloro-1,2,3,4-tetrahydro-naphthalen-2-yl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
|
C26H29Cl2N3O
|
1
|
| 1 |
Ki = 26.2 nM
|
|
|
|
CP0514985
|
US9090618, ZA28
Show/Hide
|
C22H34N6O
|
1
|
| 1 |
Ki = 26.2 nM
|
|
|
|
CP0530587
|
US9221831, 78
Show/Hide
|
C28H38N2O6
|
1
|
| 1 |
Ki = 26.28 nM
|
|
|
|
CP0431678
|
8-(8-Chloro-1,2,3,4-tetrahydro-naphthalen-2-yl)-3-(2-oxo-2-phenyl-ethyl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
|
C31H32ClN3O2
|
1
|
| 1 |
Ki = 28.8 nM
|
|
|
|
CP0573295
|
US9221831, 57
Show/Hide
|
C30H35NO6
|
1
|
| 1 |
Ki = 29.43 nM
|
|
|
|
CP0403123
|
(2R)-2-[[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]amino]-N-[(4S)-2-(3-amino-3-oxopropyl)-3-oxo-4,5-dihydro-1H-2-benzazepin-4-yl]-5-(diaminomethylideneamino)pentanamide
Show/Hide
|
C30H42N8O5
|
1
|
| 1 |
Ki = 29.9 nM
|
|
|
|
CP0413165
|
US9090618, ZA52
Show/Hide
|
C36H55N5O
|
1
|
| 1 |
Ki = 30.4 nM
|
|
|
|
CP0531762
|
US8846929, 22
Show/Hide
|
C26H39N5O
|
1
|
| 1 |
Ki = 30.4 nM
|
|
|
|
CP0491130
|
US8846929, 329
Show/Hide
|
C35H51N5O5
|
1
|
| 1 |
Ki = 31.2 nM
|
|
|
|
CP0484014
|
US9221831, 5
Show/Hide
|
C34H39N3O4
|
1
|
| 1 |
Ki = 31.23 nM
|
|
|
|
CP0529180
|
US9090618, ZA55
Show/Hide
|
C30H44N4O
|
1
|
| 1 |
Ki = 31.3 nM
|
|
|
|
CP0561350
|
US9221831, 40
Show/Hide
|
C34H41NO7
|
1
|
| 1 |
Ki = 31.61 nM
|
|
|
|
CP0387607
|
(3S,6S,9S,12R)-3,9-dibenzyl-6-(1H-indol-3-ylmethyl)-1,4,7,10-tetrazabicyclo[10.3.0]pentadecane-2,5,8,11-tetrone
Show/Hide
|
C34H35N5O4
|
1
|
| 1 |
Ki = 32 nM
|
|
|
|
CP0943136
|
US9221831, 60
Show/Hide
|
C33H39N5O4
|
1
|
| 1 |
Ki = 32.67 nM
|
|
|
|
CP0386503
|
(2S)-6-amino-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[3-[(4S)-4-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-oxo-4,5-dihydro-1H-2-benzazepin-2-yl]propanoylamino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-methylpentanoyl]amino]hexanamide
Show/Hide
|
C72H107N21O13
|
1
|
| 1 |
Ki = 33 nM
|
|
|
|
CP0529179
|
US9090618, ZA27
Show/Hide
|
C21H31N5O
|
1
|
| 1 |
Ki = 33.7 nM
|
|
|
|
CP0906695
|
US9096606, 10
Show/Hide
|
C31H40NO5+
|
1
|
| 1 |
Ki = 35.04 nM
|
|
|
|
CP0529285
|
US8846929, 313
Show/Hide
|
C30H42N4O4
|
1
|
| 1 |
Ki = 35.3 nM
|
|
|
|
CP0512686
|
US9221831, 33
Show/Hide
|
C32H47NO7
|
1
|
| 1 |
Ki = 37.04 nM
|
|
|
|
CP0544990
|
US9290488, CC01
Show/Hide
|
C30H40N4O3
|
1
|
| 1 |
Ki = 38 nM
|
|
|
|
CP0478259
|
US9221831, 94
Show/Hide
|
C34H42N2O5
|
1
|
| 1 |
Ki = 38.44 nM
|
|
|
|
CP0377805
|
[1-[4-[2-(2-benzyl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl)benzimidazol-1-yl]piperidin-1-yl]cyclooctyl]methanol
Show/Hide
|
C34H47N5O
|
1
|
| 1 |
Ki = 39 nM
|
|
|
|
CP0441775
|
8-(5,8-Dichloro-1,2,3,4-tetrahydro-naphthalen-2-yl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
|
C23H25Cl2N3O
|
1
|
| 1 |
Ki = 40.1 nM
|
|
|
|
CP0556406
|
US9175000, 14
Show/Hide
|
C34H43N3O4
|
1
|
| 1 |
Ki = 40.13 nM
|
|
|
|
CP0568166
|
US9290488, B11a(ii)
Show/Hide
|
C30H40N4O3
|
1
|
| 1 |
Ki = 40.8 nM
|
|
|
|
CP0484123
|
US9090618, O85d
Show/Hide
|
C34H48N4O4
|
1
|
| 1 |
Ki = 41.3 nM
|
|
|
|
CP0531450
|
US9221831, 38
Show/Hide
|
C43H61NO10
|
1
|
| 1 |
Ki = 42.46 nM
|
|
|
|
CP0578702
|
US9056836, 12
Show/Hide
|
C24H32N2O4
|
1
|
| 1 |
Ki = 42.53 nM
|
|
|
|
CP0966860
|
US9221831, 95
Show/Hide
|
C30H35N5O4
|
1
|
| 1 |
Ki = 43.67 nM
|
|
|
|
CP0442552
|
US9090618, ZA43
Show/Hide
|
C33H51N5O2S
|
1
|
| 1 |
Ki = 43.7 nM
|
|
|
|
CP0419034
|
8-(5-Methyl-1,2,3,4-tetrahydro-naphthalen-1-yl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
|
C24H29N3O
|
1
|
| 1 |
Ki = 44 nM
|
|
|
|
CP0448645
|
8-(5,8-Dichloro-1,2,3,4-tetrahydro-naphthalen-2-yl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
|
C23H25Cl2N3O
|
1
|
| 1 |
Ki = 44.2 nM
|
|
|
|
CP0539153
|
US9221831, 6
Show/Hide
|
C29H32N2O3S2
|
1
|
| 1 |
Ki = 45.49 nM
|
|
|
|
CP0506573
|
1-Phenyl-8-(1,2,3,4-tetrahydro-naphthalen-1-yl)-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
|
C23H27N3O
|
1
|
| 1 |
Ki = 46.3 nM
|
|
|
|
CP0399072
|
US8846929, 240
Show/Hide
|
C27H37N3O3
|
1
|
| 1 |
Ki = 46.3 nM
|
|
|
|
CP0442188
|
US8846929, 34
Show/Hide
|
C27H35N5O2
|
1
|
| 1 |
Ki = 46.34 nM
|
|
|
|
CP0401976
|
(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[3-[(4S)-4-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-oxo-4,5-dihydro-1H-2-benzazepin-2-yl]propanoylamino]-5-carbamimidamidopentanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-carbamimidamidopentanamide
Show/Hide
|
C77H106N24O13
|
1
|
| 1 |
Ki = 47 nM
|
|
|
|
CP0484016
|
US9221831, 34
Show/Hide
|
C36H55NO9
|
1
|
| 1 |
Ki = 47.06 nM
|
|
|
|
CP0504159
|
1-Phenyl-8-(1,2,3,4-tetrahydro-naphthalen-2-yl)-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
|
C23H27N3O
|
1
|
| 1 |
Ki = 47.1 nM
|
|
|
|
CP0516252
|
US9221831, 37
Show/Hide
|
C39H53NO8
|
1
|
| 1 |
Ki = 47.27 nM
|
|
|
|
CP0460113
|
8-(5,8-Dichloro-1,2,3,4-tetrahydro-naphthalen-2-yl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
|
C23H25Cl2N3O
|
1
|
| 1 |
Ki = 47.3 nM
|
|
|
|
CP0498221
|
8-(8-Chloro-1,2,3,4-tetrahydro-naphthalen-2-yl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
|
C23H26ClN3O
|
1
|
| 1 |
Ki = 48 nM
|
|
|
|
CP0351211
|
2,2-Dimethyl-3-methylamino-N-phenethyl-3-phenyl-propionamide
Show/Hide
|
C20H26N2O
|
1
|
| 1 |
Ki = 49 nM
|
|
|
|
CP0442040
|
US8846929, 311
Show/Hide
|
C32H38N4O4
|
1
|
| 1 |
Ki = 49.3 nM
|
|
|
|
CP0470339
|
US8846929, 352
Show/Hide
|
C33H40N4O4
|
1
|
| 1 |
Ki = 49.7 nM
|
|
|
|
CP0526549
|
US9090618, ZA56
Show/Hide
|
C30H44N4O
|
1
|
| 1 |
Ki = 50.1 nM
|
|
|
|
CP0957896
|
US9090618, ZA69
Show/Hide
|
C28H37N5
|
1
|
| 1 |
Ki = 51 nM
|
|
|
|
CP0572463
|
US9290488, CC02
Show/Hide
|
C32H42N4O3
|
1
|
| 1 |
Ki = 51 nM
|
|
|
|
CP0443036
|
US9175000, 15
Show/Hide
|
C39H44N2O5
|
1
|
| 1 |
Ki = 51.34 nM
|
|
|
|
CP0567031
|
US9221831, 42
Show/Hide
|
C27H36N2O5
|
1
|
| 1 |
Ki = 51.45 nM
|
|
|
|
CP0493037
|
3-Benzyl-8-(5,8-dichloro-1,2,3,4-tetrahydro-naphthalen-2-yl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
|
C30H31Cl2N3O
|
1
|
| 1 |
Ki = 52 nM
|
|
|
|
CP0519022
|
US9175000, 12
Show/Hide
|
C33H40N2O5
|
1
|
| 1 |
Ki = 52.21 nM
|
|
|
|
CP0466707
|
US8846929, 120
Show/Hide
|
C31H39N5O3
|
1
|
| 1 |
Ki = 55.8 nM
|
|
|
|
CP0858784
|
US9096606, 8
Show/Hide
|
C34H44NO5+
|
1
|
| 1 |
Ki = 56.98 nM
|
|
|
|
CP0529283
|
US8846929, 39
Show/Hide
|
C25H37N5O
|
1
|
| 1 |
Ki = 57.3 nM
|
|
|
|
CP0426229
|
US9090618, ZA50
Show/Hide
|
C33H51N5O2S
|
1
|
| 1 |
Ki = 58.3 nM
|
|
|
|
CP0518184
|
US9090618, ZA26
Show/Hide
|
C23H35N5O
|
1
|
| 1 |
Ki = 59 nM
|
|
|
|
CP0491120
|
US8846929, 364
Show/Hide
|
C27H35N3O3
|
1
|
| 1 |
Ki = 63 nM
|
|
|
|
CP0491131
|
US8846929, 300
Show/Hide
|
C33H40N4O4
|
1
|
| 1 |
Ki = 63.4 nM
|
|
|
|
CP0545906
|
US8846929, 282
Show/Hide
|
C29H35N5O3
|
1
|
| 1 |
Ki = 64.2 nM
|
|
|
|
CP0452601
|
US9056836, 10
Show/Hide
|
C22H29NO5
|
1
|
| 1 |
Ki = 64.47 nM
|
|
|
|
CP0484018
|
US9221831, 56
Show/Hide
|
C31H37NO6
|
1
|
| 1 |
Ki = 64.53 nM
|
|
|
|
CP0538967
|
US9090618, H30b(ii)
Show/Hide
|
C31H44N4O2
|
1
|
| 1 |
Ki = 65.2 nM
|
|
|
|
CP0495520
|
US9388162, 48
Show/Hide
|
C30H37NO4
|
1
|
| 1 |
Ki = 65.3 nM
|
|
|
|
CP0470332
|
US8846929, 153
Show/Hide
|
C26H35N3O3
|
1
|
| 1 |
Ki = 66 nM
|
|
|
|
CP0924248
|
US9096606, 2
Show/Hide
|
C34H41ClNO6+
|
1
|
| 1 |
Ki = 66.73 nM
|
|
|
|
CP0464044
|
US8846929, 189
Show/Hide
|
C30H40N6O3
|
1
|
| 1 |
Ki = 67 nM
|
|
|
|
CP0520566
|
US8846929, 31
Show/Hide
|
C26H39N5O
|
1
|
| 1 |
Ki = 67.5 nM
|
|
|
|
CP0402464
|
US9290488, B34a
Show/Hide
|
C31H42N4O3
|
1
|
| 1 |
Ki = 72.3 nM
|
|
|
|
CP0450030
|
US9340542, 8
Show/Hide
|
C22H27N3O3
|
1
|
| 1 |
Ki = 72.5 nM
|
|
|
|
CP0529287
|
US8846929, 10
Show/Hide
|
C25H37N5O
|
1
|
| 1 |
Ki = 73.5 nM
|
|
|
|
CP0101248
|
N-(cyclopropylmethyl)-3-(3-hydroxyphenyl)-2,2-dimethyl-3-(methylamino)propanamide
Show/Hide
|
C16H24N2O2
|
1
|
| 1 |
Ki = 75 nM
|
|
|
|
CP0311104
|
3-(Butyl-methyl-amino)-3-(3-hydroxy-phenyl)-2,2-dimethyl-N-phenethyl-propionamide
Show/Hide
|
C24H34N2O2
|
1
|
| 1 |
Ki = 75 nM
|
|
|
|
CP0086136
|
US8476271, 405
Show/Hide
|
C27H35N3O3
|
1
|
| 1 |
Ki = 75.4 nM
|
|
|
|
CP0223449
|
US8846929, 356
Show/Hide
|
C28H39N3O3
|
1
|
| 1 |
Ki = 76 nM
|
|
|
|
CP0556941
|
US9090618, ZA70
Show/Hide
|
C29H38ClN5
|
1
|
| 1 |
Ki = 79 nM
|
|
|
|
CP0447764
|
US9056836, 22
Show/Hide
|
C20H28N2O3
|
1
|
| 1 |
Ki = 79.08 nM
|
|
|
|
CP0486328
|
US9388162, 72
Show/Hide
|
C24H33NO2
|
1
|
| 1 |
Ki = 82.9 nM
|
|
|
|
CP0529288
|
US8846929, 86
Show/Hide
|
C21H31N3O
|
1
|
| 1 |
Ki = 83.5 nM
|
|
|
|
CP0380599
|
(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[3-[(4S)-4-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-oxo-4,5-dihydro-1H-2-benzazepin-2-yl]propanoylamino]-5-carbamimidamidopentanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-(4-fluorophenyl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-carbamimidamidopentanamide
Show/Hide
|
C77H105FN24O12
|
1
|
| 1 |
Ki = 84 nM
|
|
|
|
CP0443717
|
US8846929, 302
Show/Hide
|
C25H35N3O3
|
1
|
| 1 |
Ki = 85.4 nM
|
|
|
|
CP0445197
|
US9290488, L2b(ii)
Show/Hide
|
C30H40N4O3
|
1
|
| 1 |
Ki = 86 nM
|
|
|
|
CP0423897
|
US9221831, 96
Show/Hide
|
C34H41NO6
|
1
|
| 1 |
Ki = 87.27 nM
|
|
|
|
CP0272526
|
8-[(1R,3aR)-2,3,3a,4,5,6-hexahydro-1H-phenalen-1-yl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
Show/Hide
|
C26H31N3O
|
1
|
| 1 |
Ki = 89 nM
|
|
|
|
CP0957292
|
US9090618, ZA68
Show/Hide
|
C28H37N5
|
1
|
| 1 |
Ki = 89.6 nM
|
|
|
|
CP0450522
|
US9056836, 19
Show/Hide
|
C20H29NO3
|
1
|
| 1 |
Ki = 89.61 nM
|
|
|
|
CP0503753
|
US8846929, 15
Show/Hide
|
C21H30N4O
|
1
|
| 1 |
Ki = 92.9 nM
|
|
|
|
CP0405142
|
2-benzyl-1'-(4-tert-butylcyclohexyl)-2,3-dihydro-1H-spiro[isoquinoline-4,4'-piperidine]-3-one
Show/Hide
|
C30H40N2O
|
1
|
| 1 |
Ki = 97 nM
|
|
|
|
CP0121280
|
7-[2-[2-(3-chlorophenyl)ethylamino]ethyl]quinolin-2-amine
Show/Hide
|
C19H20ClN3
|
1
|
| 1 |
Ki < 100 nM
|
|
|
|
CP0503751
|
US8846929, 328
Show/Hide
|
C31H45N5O3
|
1
|
| 1 |
Ki = 102 nM
|
|
|
|
CP0405144
|
7-fluoro-2-methyl-1'-[4-(propan-2-yl)cyclohexyl]-2,3-dihydro-1H-spiro[isoquinoline-4,4'-piperidine]-3-one
Show/Hide
|
C23H33FN2O
|
1
|
| 1 |
Ki = 103 nM
|
|
|
|
CP0450741
|
US9090618, H56b(i)
Show/Hide
|
C32H46N4O2
|
1
|
| 1 |
Ki = 108 nM
|
|
|
|
CP0413120
|
US9290488, B21a
Show/Hide
|
C31H40N4O3
|
1
|
| 1 |
Ki = 111.4 nM
|
|
|
|
CP0442217
|
US9096606, 23
Show/Hide
|
C35H44F2NO4+
|
1
|
| 1 |
Ki = 112.07 nM
|
|
|
|
CP0544987
|
US9290488, B12a
Show/Hide
|
C30H40N4O3
|
1
|
| 1 |
Ki = 113 nM
|
|
|
|
CP0450740
|
US9090618, ZA60
Show/Hide
|
C30H39N5
|
1
|
| 1 |
Ki = 114.8 nM
|
|
|
|
CP0402465
|
US9290488, A11a(ii)
Show/Hide
|
C29H38N4O3
|
1
|
| 1 |
Ki = 116 nM
|
|
|
|
CP0906694
|
US9096606, 3
Show/Hide
|
C34H44NO4+
|
1
|
| 1 |
Ki = 117.13 nM
|
|
|
|
CP0526528
|
US8637502, 60
Show/Hide
|
C23H27N3O2
|
1
|
| 1 |
Ki = 119 nM
|
|
|
|
CP0437155
|
2-benzyl-5-fluoro-1'-[4-(propan-2-yl)cyclohexyl]-2,3-dihydro-1H-spiro[isoquinoline-4,4'-piperidine]-3-one
Show/Hide
|
C29H37FN2O
|
1
|
| 1 |
Ki = 123 nM
|
|
|
|
CP0413164
|
US9090618, H36b(i)
Show/Hide
|
C31H45N5O
|
1
|
| 1 |
Ki = 123 nM
|
|
|
|
CP0519422
|
US9290488, E53a(i)
Show/Hide
|
C31H42N4O3
|
1
|
| 1 |
Ki = 128 nM
|
|
|
|
CP0470179
|
US9388162, 17
Show/Hide
|
C27H34N2O6
|
1
|
| 1 |
Ki = 128.06 nM
|
|
|
|
CP0903202
|
US8846929, 351
Show/Hide
|
C30H38N6O4
|
1
|
| 1 |
Ki = 129.5 nM
|
|
|
|
CP0954558
|
US9090618, ZA61
Show/Hide
|
C29H40N6
|
1
|
| 1 |
Ki = 130 nM
|
|
|
|
CP0515132
|
US8846929, 87
Show/Hide
|
C26H38N6O
|
1
|
| 1 |
Ki = 130 nM
|
|
|
|
CP0529284
|
US8846929, 80
Show/Hide
|
C28H35N5O3
|
1
|
| 1 |
Ki = 132 nM
|
|
|
|
CP0470952
|
US8846929, 216
Show/Hide
|
C31H43N5O3
|
1
|
| 1 |
Ki = 134 nM
|
|
|
|
CP0530685
|
US9290488, K29b
Show/Hide
|
C30H40N4O3
|
1
|
| 1 |
Ki = 135 nM
|
|
|
|
CP0464914
|
US8846929, 4
Show/Hide
|
C32H47N5O3
|
1
|
| 1 |
Ki = 135.8 nM
|
|
|
|
CP0519421
|
US9290488, B20a(i)
Show/Hide
|
C31H40N4O3
|
1
|
| 1 |
Ki = 137 nM
|
|
|
|
CP0449966
|
US9175000, 13
Show/Hide
|
C34H42N2O5
|
1
|
| 1 |
Ki = 138.42 nM
|
|
|
|
CP0491126
|
US8846929, 70
Show/Hide
|
C24H33N3O3
|
1
|
| 1 |
Ki = 141 nM
|
|
|
|
CP0531780
|
US8846929, 308
Show/Hide
|
C28H38N4O4
|
1
|
| 1 |
Ki = 144 nM
|
|
|
|
CP0486327
|
US9388162, 19
Show/Hide
|
C28H38N2O6
|
1
|
| 1 |
Ki = 145.53 nM
|
|
|
|
CP0946010
|
US9340542, 7
Show/Hide
|
C24H27N3O3
|
1
|
| 1 |
Ki = 147.6 nM
|
|
|
|
CP0512280
|
US9340542, 9
Show/Hide
|
C22H27N3O3
|
1
|
| 1 |
Ki = 147.8 nM
|
|
|
|
CP0374654
|
8-(6-Chloro-1,2,3,4-tetrahydro-naphthalen-2-yl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
|
C23H26ClN3O
|
1
|
| 1 |
Ki = 149 nM
|
|
|
|
CP0478853
|
US9090618, H30b(i)
Show/Hide
|
C31H44N4O2
|
1
|
| 1 |
Ki = 150 nM
|
|
|
|
CP0442032
|
US8846929, 21
Show/Hide
|
C31H47N5O3
|
1
|
| 1 |
Ki = 151 nM
|
|
|
|
CP0503757
|
US8846929, 102
Show/Hide
|
C26H38N4O3
|
1
|
| 1 |
Ki = 156 nM
|
|
|
|
CP0529482
|
US9290488, B20a(ii)
Show/Hide
|
C31H40N4O3
|
1
|
| 1 |
Ki = 159 nM
|
|
|
|
CP0289733
|
8-Indan-2-yl-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one
Show/Hide
|
C22H25N3O
|
1
|
| 1 |
Ki = 161 nM
|
|
|
|
CP0442036
|
US8846929, 69
Show/Hide
|
C24H33N3O2
|
1
|
| 1 |
Ki = 161 nM
|
|
|
|
CP0899416
|
US8846929, 122
Show/Hide
|
C29H35N5O3
|
1
|
| 1 |
Ki = 161 nM
|
|
|
|
CP0443715
|
US8846929, 301
Show/Hide
|
C26H37N3O3
|
1
|
| 1 |
Ki = 162 nM
|
|
|
|
CP0899389
|
US9096606, 13
Show/Hide
|
C37H44NO4+
|
1
|
| 1 |
Ki = 165.12 nM
|
|
|
|
CP0551139
|
US8846929, 6
Show/Hide
|
C28H36N4O
|
1
|
| 1 |
Ki = 165.2 nM
|
|
|
|
CP0517947
|
US8637502, 6
Show/Hide
|
C21H29N3O2
|
1
|
| 1 |
Ki = 167 nM
|
|
|
|
CP0484463
|
US8846929, 9
Show/Hide
|
C23H35N5O
|
1
|
| 1 |
Ki = 167.6 nM
|
|
|
|
CP0550113
|
US9090618, ZA59
Show/Hide
|
C33H48N4O2
|
1
|
| 1 |
Ki = 169 nM
|
|
|
|
CP0551328
|
US8637502, 57
Show/Hide
|
C24H33N3O2
|
1
|
| 1 |
Ki = 170 nM
|
|
|
|
CP0529289
|
US8846929, 312
Show/Hide
|
C27H36N4O4
|
1
|
| 1 |
Ki = 172 nM
|
|
|
|
CP0067482
|
(3R)-1-[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]-N-[(2S)-1-[[(1S)-2-carbamoyl-1-phenylprop-2-enyl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]pyrrolidine-3-carboxamide
Show/Hide
|
C37H42N6O5
|
1
|
| 1 |
Ki = 174 nM
|
|
|
|
CP0491125
|
US8846929, 58
Show/Hide
|
C24H37N5O2
|
1
|
| 1 |
Ki = 175 nM
|
|
|
|
CP0500714
|
1'-(4-tert-butylcyclohexyl)-2-methyl-2,3-dihydro-1H-spiro[isoquinoline-4,4'-piperidine]-3-one
Show/Hide
|
C24H36N2O
|
1
|
| 1 |
Ki = 178 nM
|
|
|
|
CP0441681
|
3-(1-(cyclooctylmethyl)piperidin-4-yl)-5-fluoro-1H-indole
Show/Hide
|
C22H31FN2
|
1
|
| 1 |
Ki = 180 nM
|
|
|
|
CP0128897
|
(3S)-1-[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]-N-[(2S)-1-[[(1R)-2-carbamoyl-1-(furan-2-yl)prop-2-enyl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]pyrrolidine-3-carboxamide
Show/Hide
|
C35H40N6O6
|
1
|
| 1 |
Ki = 180 nM
|
|
|
|
CP0466574
|
US8846929, 129
Show/Hide
|
C27H36N4O5
|
1
|
| 1 |
Ki = 180 nM
|
|
|
|
CP0962091
|
US9221831, 54
Show/Hide
|
C34H41N5O4
|
1
|
| 1 |
Ki = 180.85 nM
|
|
|
|
CP0510254
|
US8846929, 85
Show/Hide
|
C21H31N3O
|
1
|
| 1 |
Ki = 182 nM
|
|
|
|
CP0507886
|
US9290488, L2b(i)
Show/Hide
|
C30H40N4O3
|
1
|
| 1 |
Ki = 188 nM
|
|
|
|
CP0437142
|
2-benzyl-1'-(4-tert-butylcyclohexyl)-5-fluoro-2,3-dihydro-1H-spiro[isoquinoline-4,4'-piperidine]-3-one
Show/Hide
|
C30H39FN2O
|
1
|
| 1 |
Ki = 190 nM
|
|
|
|
CP0495519
|
US9388162, 15
Show/Hide
|
C25H32N2O6
|
1
|
| 1 |
Ki = 190.65 nM
|
|
|
|
CP0443704
|
US8846929, 46
Show/Hide
|
C25H36N4O4
|
1
|
| 1 |
Ki = 191 nM
|
|
|
|
CP0443703
|
US8846929, 26
Show/Hide
|
C24H37N7O
|
1
|
| 1 |
Ki = 191.4 nM
|
|
|
|
CP0185280
|
2-[(S)-[[(2S)-2-[[(2S)-1-[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-phenylmethyl]prop-2-enoic acid
Show/Hide
|
C37H41N5O6
|
1
|
| 1 |
Ki = 192 nM
|
|
|
|
CP0185281
|
2-[(R)-[[(2S)-2-[[(2S)-1-[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-(furan-2-yl)methyl]prop-2-enoic acid
Show/Hide
|
C35H39N5O7
|
1
|
| 1 |
Ki = 200 nM
|
|
|
|
CP0067669
|
(3R)-1-[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]-N-[(2S)-1-[[(1R)-2-carbamoyl-1-(furan-2-yl)prop-2-enyl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]pyrrolidine-3-carboxamide
Show/Hide
|
C35H40N6O6
|
1
|
| 1 |
Ki = 205 nM
|
|
|
|
CP0491117
|
US8846929, 309
Show/Hide
|
C29H40N4O4S
|
1
|
| 1 |
Ki = 210 nM
|
|
|
|
CP0443712
|
US8846929, 337
Show/Hide
|
C29H41N5O3
|
1
|
| 1 |
Ki = 220 nM
|
|
|
|
CP0442024
|
US8846929, 37
Show/Hide
|
C27H39N5O2
|
1
|
| 1 |
Ki = 222.01 nM
|
|
|
|
CP0490203
|
US9290488, K2b(ii)
Show/Hide
|
C29H38N4O3
|
1
|
| 1 |
Ki = 223 nM
|
|
|
|
CP0545907
|
US8846929, 284
Show/Hide
|
C29H41N5O3
|
1
|
| 1 |
Ki = 223.4 nM
|
|
|
|
CP0397974
|
4-anilino-1-benzyl-N-[2-(diaminomethylideneamino)ethyl]piperidine-4-carboxamide
Show/Hide
|
C22H30N6O
|
1
|
| 1 |
Ki = 224 nM
|
|
|
|
CP0450106
|
US8846929, 193
Show/Hide
|
C29H41N5O3
|
1
|
| 1 |
Ki = 224 nM
|
|
|
|
CP0491129
|
US8846929, 310
Show/Hide
|
C28H36N4O6
|
1
|
| 1 |
Ki = 229 nM
|
|
|
|
CP0067481
|
(3S)-1-[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]-N-[(2S)-1-[[(1S)-2-carbamoyl-1-phenylprop-2-enyl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]pyrrolidine-3-carboxamide
Show/Hide
|
C37H42N6O5
|
1
|
| 1 |
Ki = 240 nM
|
|
|
|
CP0442038
|
US8846929, 84
Show/Hide
|
C29H36N4O3
|
1
|
| 1 |
Ki = 245 nM
|
|
|
|
CP0450742
|
US9090618, ZA35
Show/Hide
|
C25H35N3O
|
1
|
| 1 |
Ki = 246 nM
|
|
|
|
CP0518469
|
US9388162, 24
Show/Hide
|
C28H33NO4
|
1
|
| 1 |
Ki = 249.2 nM
|
|
|
|
CP0472349
|
US8846929, 128
Show/Hide
|
C27H36N4O4
|
1
|
| 1 |
Ki = 250 nM
|
|
|
|
CP0519156
|
US8846929, 90
Show/Hide
|
C25H35N5O2
|
1
|
| 1 |
Ki = 253 nM
|
|
|
|
CP0406798
|
US9090618, H58d(ii)
Show/Hide
|
C33H48N4O2
|
1
|
| 1 |
Ki = 254 nM
|
|
|
|
CP0417247
|
US8846929, 194
Show/Hide
|
C31H43N5O4
|
1
|
| 1 |
Ki = 256 nM
|
|
|
|
CP0442030
|
US8846929, 2
Show/Hide
|
C23H34N4O
|
1
|
| 1 |
Ki = 257 nM
|
|
|
|
CP0493189
|
US9388162, 8
Show/Hide
|
C23H29NO5
|
1
|
| 1 |
Ki = 260.85 nM
|
|
|
|
CP0479195
|
US9090618, ZA33
Show/Hide
|
C27H40N4O2
|
1
|
| 1 |
Ki = 265 nM
|
|
|
|
CP0445196
|
US9290488, E53a(ii)
Show/Hide
|
C31H42N4O3
|
1
|
| 1 |
Ki = 274 nM
|
|
|
|
CP0529282
|
US8846929, 13
Show/Hide
|
C29H41N5O2
|
1
|
| 1 |
Ki = 283 nM
|
|
|
|
CP0544986
|
US9290488, B2a(ii)
Show/Hide
|
C29H38N4O3
|
1
|
| 1 |
Ki = 289 nM
|
|
|
|
CP0529286
|
US8846929, 7
Show/Hide
|
C28H43N5O3
|
1
|
| 1 |
Ki = 296 nM
|
|
|
|
CP0503746
|
US8846929, 44
Show/Hide
|
C32H40N4O3
|
1
|
| 1 |
Ki = 301 nM
|
|
|
|
CP0450787
|
US8846929, 18
Show/Hide
|
C25H35N5O2
|
1
|
| 1 |
Ki = 303 nM
|
|
|
|
CP0540038
|
US9290488, A11a(i)
Show/Hide
|
C29H38N4O3
|
1
|
| 1 |
Ki = 323 nM
|
|
|
|
CP0409260
|
US9388162, 49
Show/Hide
|
C24H33NO4
|
1
|
| 1 |
Ki = 324.4 nM
|
|
|
|
CP0503754
|
US8846929, 16
Show/Hide
|
C28H40N4O3
|
1
|
| 1 |
Ki = 328 nM
|
|
|
|
CP0403752
|
3-(1-benzylpiperidin-4-yl)-5-chloro-1H-indole
Show/Hide
|
C20H21ClN2
|
1
|
| 1 |
Ki = 330 nM
|
|
|
|
CP0449437
|
5-chloro-3-(1-(cyclooctylmethyl)piperidin-4-yl)-2-methyl-1H-indole
Show/Hide
|
C23H33ClN2
|
1
|
| 1 |
Ki = 330 nM
|
|
|
|
CP0466577
|
US8846929, 207
Show/Hide
|
C31H38N4O3
|
1
|
| 1 |
Ki = 346 nM
|
|
|
|
CP0950558
|
US9096606, 9
Show/Hide
|
C32H40NO4+
|
1
|
| 1 |
Ki = 348.08 nM
|
|
|
|
CP0399425
|
US8846929, 306
Show/Hide
|
C29H38N4O4
|
1
|
| 1 |
Ki = 350 nM
|
|
|
|
CP0412095
|
US9090618, B56c(ii)
Show/Hide
|
C31H44N4O2
|
1
|
| 1 |
Ki = 353 nM
|
|
|
|
CP0510249
|
US8846929, 32
Show/Hide
|
C23H33N5O2
|
1
|
| 1 |
Ki = 354 nM
|
|
|
|
CP0472344
|
US8637502, 5
Show/Hide
|
C22H31N3O2
|
1
|
| 1 |
Ki = 355 nM
|
|
|
|
CP0066194
|
N-[2-(1,3-benzodioxol-5-yl)ethyl]-N-[2-(3,4-dimethoxyphenyl)ethyl]-3-phenylpropan-1-amine
Show/Hide
|
C28H33NO4
|
1
|
| 1 |
Ki = 363 nM
|
|
|
|
CP0399430
|
US8846929, 336
Show/Hide
|
C25H31N3O3
|
1
|
| 1 |
Ki = 365 nM
|
|
|
|
CP0450789
|
US8846929, 38
Show/Hide
|
C29H36N4O
|
1
|
| 1 |
Ki = 375 nM
|
|
|
|
CP0470955
|
US8846929, 290
Show/Hide
|
C26H35N3O3
|
1
|
| 1 |
Ki = 375 nM
|
|
|
|
CP0520565
|
US8846929, 30
Show/Hide
|
C27H41N5O3S
|
1
|
| 1 |
Ki = 378 nM
|
|
|
|
CP0510251
|
US8846929, 57
Show/Hide
|
C25H36N4O3
|
1
|
| 1 |
Ki = 379 nM
|
|
|
|
CP0402596
|
US8846929, 125
Show/Hide
|
C27H38N4O4
|
1
|
| 1 |
Ki = 380 nM
|
|
|
|
CP0450102
|
US8846929, 119
Show/Hide
|
C24H33N5O2
|
1
|
| 1 |
Ki = 381 nM
|
|
|
|
CP0377807
|
(1-{4-[2-(3,3-Dimethylpiperazin-1-yl)-1H-benzimidazol-1-yl]piperidin-1-yl}cyclooctyl)methanol
Show/Hide
|
C27H43N5O
|
1
|
| 1 |
Ki = 387 nM
|
|
|
|
CP0510253
|
US8846929, 82
Show/Hide
|
C27H33N5O3
|
1
|
| 1 |
Ki = 391 nM
|
|
|
|
CP0507283
|
US9388162, 46
Show/Hide
|
C23H31NO4
|
1
|
| 1 |
Ki = 394.2 nM
|
|
|
|
CP0561347
|
US9221831, 12
Show/Hide
|
C25H31N3O3S2
|
1
|
| 1 |
Ki = 399.88 nM
|
|
|
|
CP0451427
|
US9388162, 1
Show/Hide
|
C25H33NO5
|
1
|
| 1 |
Ki = 407.78 nM
|
|
|
|
CP0405146
|
5-fluoro-2-methyl-1'-[4-(propan-2-yl)cyclohexyl]-2,3-dihydro-1H-spiro[isoquinoline-4,4'-piperidine]-3-one
Show/Hide
|
C23H33FN2O
|
1
|
| 1 |
Ki = 412 nM
|
|
|
|
CP0503749
|
US8846929, 77
Show/Hide
|
C22H30N4O2
|
1
|
| 1 |
Ki = 418 nM
|
|
|
|
CP0412569
|
US8846929, 126
Show/Hide
|
C27H40N4O4
|
1
|
| 1 |
Ki = 422 nM
|
|
|
|
CP0520136
|
US8846929, 294
Show/Hide
|
C26H35N3O3
|
1
|
| 1 |
Ki = 425 nM
|
|
|
|
CP0557345
|
US8846929, 178
Show/Hide
|
C28H39N5O3
|
1
|
| 1 |
Ki = 429 nM
|
|
|
|
CP0570755
|
US9221831, 43
Show/Hide
|
C35H42N2O7
|
1
|
| 1 |
Ki = 434.84 nM
|
|
|
|
CP0418230
|
US8637502, 12
Show/Hide
|
C25H23N3O2
|
1
|
| 1 |
Ki = 439 nM
|
|
|
|
CP0483216
|
US8846929, 241
Show/Hide
|
C25H33N3O3
|
1
|
| 1 |
Ki = 440 nM
|
|
|
|
CP0538970
|
US9090618, ZA58
Show/Hide
|
C33H48N4O2
|
1
|
| 1 |
Ki = 444 nM
|
|
|
|
CP0483217
|
US8846929, 279
Show/Hide
|
C28H39N5O3
|
1
|
| 1 |
Ki = 447 nM
|
|
|
|
CP0519154
|
US8846929, 59
Show/Hide
|
C27H39N5O2
|
1
|
| 1 |
Ki = 457 nM
|
|
|
|
CP0569075
|
US8846929, 121
Show/Hide
|
C25H34N4O3
|
1
|
| 1 |
Ki = 460 nM
|
|
|
|
CP0423891
|
US9221831, 13
Show/Hide
|
C24H29N3O3S2
|
1
|
| 1 |
Ki = 461.98 nM
|
|
|
|
CP0196420
|
N-benzyl-2,2-dimethyl-3-(methylamino)-3-phenylpropanamide
Show/Hide
|
C19H24N2O
|
1
|
| 1 |
Ki = 467 nM
|
|
|
|
CP0483219
|
US8846929, 298
Show/Hide
|
C25H33N3O3
|
1
|
| 1 |
Ki = 469 nM
|
|
|
|
CP0491116
|
US8846929, 307
Show/Hide
|
C27H36N4O4
|
1
|
| 1 |
Ki = 478 nM
|
|
|
|
CP0464918
|
US8846929, 127
Show/Hide
|
C24H32N4O3
|
1
|
| 1 |
Ki = 480 nM
|
|
|
|
CP0443720
|
US8846929, 366
Show/Hide
|
C22H29N3O3
|
1
|
| 1 |
Ki = 480.5 nM
|
|
|
|
CP0519153
|
US8846929, 29
Show/Hide
|
C27H39N5O2
|
1
|
| 1 |
Ki = 481 nM
|
|
|
|
CP0535561
|
US8846929, 174
Show/Hide
|
C29H39N5O4
|
1
|
| 1 |
Ki = 488 nM
|
|
|
|
CP0442039
|
US8846929, 133
Show/Hide
|
C24H30FN3O3
|
1
|
| 1 |
Ki = 501 nM
|
|
|
|
CP0441924
|
US8846929, 60
Show/Hide
|
C27H39N5O2
|
1
|
| 1 |
Ki = 510 nM
|
|
|
|
CP0450777
|
US8846929, 23
Show/Hide
|
C28H41N5O2
|
1
|
| 1 |
Ki = 514 nM
|
|
|
|
CP0517846
|
US9221831, 46
Show/Hide
|
C34H41NO6
|
1
|
| 1 |
Ki = 516.58 nM
|
|
|
|
CP0510256
|
US8846929, 304
Show/Hide
|
C23H31N3O3
|
1
|
| 1 |
Ki = 523 nM
|
|
|
|
CP0544765
|
US8846929, 209
Show/Hide
|
C32H40N4O3
|
1
|
| 1 |
Ki = 534 nM
|
|
|
|
CP0503750
|
US8846929, 88
Show/Hide
|
C22H28N4O
|
1
|
| 1 |
Ki = 536 nM
|
|
|
|
CP0512244
|
US8846929, 56
Show/Hide
|
C24H34N4O4
|
1
|
| 1 |
Ki = 544 nM
|
|
|
|
CP0450790
|
US8846929, 43
Show/Hide
|
C30H38N4O
|
1
|
| 1 |
Ki = 544.2 nM
|
|
|
|
CP0437154
|
2-methyl-1'-[4-(propan-2-yl)cyclohexyl]-2,3-dihydro-1H-spiro[isoquinoline-4,4'-piperidine]-3-one
Show/Hide
|
C23H34N2O
|
1
|
| 1 |
Ki = 557 nM
|
|
|
|
CP0550161
|
US8637502, 47
Show/Hide
|
C25H36N4O3
|
1
|
| 1 |
Ki = 559 nM
|
|
|
|
CP0554241
|
US8846929, 288
Show/Hide
|
C27H37N3O3
|
1
|
| 1 |
Ki = 565 nM
|
|
|
|
CP0921412
|
US9090618, ZA39
Show/Hide
|
C26H35N7
|
1
|
| 1 |
Ki = 566 nM
|
|
|
|
CP0413138
|
US8846929, 211
Show/Hide
|
C31H45N5O3
|
1
|
| 1 |
Ki = 568 nM
|
|
|
|
CP0450788
|
US8846929, 27
Show/Hide
|
C27H38N4O3
|
1
|
| 1 |
Ki = 583 nM
|
|
|
|
CP0399423
|
US8846929, 83
Show/Hide
|
C23H32N4O3
|
1
|
| 1 |
Ki = 586 nM
|
|
|
|
CP0553793
|
US8846929, 66
Show/Hide
|
C26H39N5O3S
|
1
|
| 1 |
Ki = 587 nM
|
|
|
|
CP0529291
|
US8846929, 353
Show/Hide
|
C31H45N5O3
|
1
|
| 1 |
Ki = 589 nM
|
|
|
|
CP0450739
|
US9090618, ZA29
Show/Hide
|
C24H35N5O3
|
1
|
| 1 |
Ki = 594 nM
|
|
|
|
CP0491123
|
US8846929, 42
Show/Hide
|
C26H37N5O2
|
1
|
| 1 |
Ki = 611.9 nM
|
|
|
|
CP0412097
|
US9090618, ZA48
Show/Hide
|
C33H48N4O2
|
1
|
| 1 |
Ki = 614 nM
|
|
|
|
CP0491110
|
US8846929, 78
Show/Hide
|
C23H32N4O2
|
1
|
| 1 |
Ki = 618 nM
|
|
|
|
CP0491121
|
US8846929, 17
Show/Hide
|
C23H32N4O2
|
1
|
| 1 |
Ki = 622 nM
|
|
|
|
CP0520571
|
US8846929, 243
Show/Hide
|
C24H31N3O3
|
1
|
| 1 |
Ki = 630 nM
|
|
|
|
CP0279176
|
US8476271, 18
Show/Hide
|
C27H37N3O3
|
1
|
| 1 |
Ki = 640 nM
|
|
|
|
CP0383582
|
US8846929, 99
Show/Hide
|
C29H40N4O3
|
1
|
| 1 |
Ki = 657 nM
|
|
|
|
CP0484466
|
US8846929, 67
Show/Hide
|
C24H36N4O3
|
1
|
| 1 |
Ki = 666 nM
|
|
|
|
CP0069223
|
4-[4-chloro-3-(trifluoromethyl)phenyl]-1-[3-(4-fluoro-N-(4-fluorophenyl)anilino)propyl]piperidin-4-ol
Show/Hide
|
C27H26ClF5N2O
|
1
|
| 1 |
Ki = 667 nM
|
|
|
|
CP0484468
|
US8846929, 81
Show/Hide
|
C24H34N4O2
|
1
|
| 1 |
Ki = 669 nM
|
|
|
|
CP0531764
|
US8846929, 327
Show/Hide
|
C31H43N5O5
|
1
|
| 1 |
Ki = 672.5 nM
|
|
|
|
CP0441682
|
5-chloro-3-(1-(1,2-dihydroacenaphthylen-1-yl)piperidin-4-yl)-2-methyl-1H-indole
Show/Hide
|
C26H25ClN2
|
1
|
| 1 |
Ki = 680 nM
|
|
|
|
CP0450748
|
US8637502, 61
Show/Hide
|
C23H27N3O2
|
1
|
| 1 |
Ki = 682 nM
|
|
|
|
CP0443711
|
US8846929, 92
Show/Hide
|
C25H36N4O2
|
1
|
| 1 |
Ki = 688 nM
|
|
|
|
CP0500380
|
US9090618, H56d(ii)
Show/Hide
|
C32H46N4O2
|
1
|
| 1 |
Ki = 700 nM
|
|
|
|
CP0386893
|
N-[[1-benzyl-4-(naphthalen-1-ylamino)piperidin-4-yl]methyl]-2-(diaminomethylideneamino)acetamide
Show/Hide
|
C26H32N6O
|
1
|
| 1 |
Ki = 705 nM
|
|
|
|
CP0402598
|
US8846929, 226
Show/Hide
|
C27H39N5O3
|
1
|
| 1 |
Ki = 707 nM
|
|
|
|
CP0428064
|
3-(1-(naphthalen-1-ylmethyl)piperidin-4-yl)-1H-pyrrolo[2,3-b]pyridine
Show/Hide
|
C23H23N3
|
1
|
| 1 |
Ki = 710 nM
|
|
|
|
CP0542020
|
US8846929, 52
Show/Hide
|
C26H38N4O2
|
1
|
| 1 |
Ki = 712 nM
|
|
|
|
CP0557306
|
US8846929, 47
Show/Hide
|
C24H35N5O2
|
1
|
| 1 |
Ki = 731 nM
|
|
|
|
CP0204782
|
(2S)-2-[[(2R,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-5-(diaminomethylideneamino)pentanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-methylpentanoyl]amino]-6-aminohexanamide
Show/Hide
|
C44H70N14O9
|
1
|
| 1 |
Ki = 732 nM
|
|
|
|
CP0556940
|
US8846929, 221
Show/Hide
|
C29H42N6O4
|
1
|
| 1 |
Ki = 740 nM
|
|
|
|
CP0466709
|
US8846929, 123
Show/Hide
|
C30H37N5O3
|
1
|
| 1 |
Ki = 743 nM
|
|
|
|
CP0453004
|
5-chloro-2-methyl-3-(1-(naphthalen-1-ylmethyl)piperidin-4-yl)-1H-indole
Show/Hide
|
C25H25ClN2
|
1
|
| 1 |
Ki = 750 nM
|
|
|
|
CP0492151
|
US8846929, 203
Show/Hide
|
C30H41N5O4
|
1
|
| 1 |
Ki = 750 nM
|
|
|
|
CP0402716
|
US9315514, 7
Show/Hide
|
C36H45NO4
|
1
|
| 1 |
Ki = 757 nM
|
|
|
|
CP0515133
|
US8846929, 305
Show/Hide
|
C31H38N4O3
|
1
|
| 1 |
Ki = 780 nM
|
|
|
|
CP0450781
|
US8846929, 45
Show/Hide
|
C26H33N5O2
|
1
|
| 1 |
Ki = 805 nM
|
|
|
|
CP0484465
|
US8846929, 61
Show/Hide
|
C26H38N4O3
|
1
|
| 1 |
Ki = 810 nM
|
|
|
|
CP0425428
|
5-fluoro-3-(1-(naphthalen-1-ylmethyl)piperidin-4-yl)-1H-indole
Show/Hide
|
C24H23FN2
|
1
|
| 1 |
Ki = 820 nM
|
|
|
|
CP0426226
|
US9090618, ZA10
Show/Hide
|
C34H50N4O2
|
1
|
| 1 |
Ki = 822 nM
|
|
|
|
CP0479194
|
US9090618, H32b(ii)
Show/Hide
|
C32H46N4O2
|
1
|
| 1 |
Ki = 828 nM
|
|
|
|
CP0450785
|
US8846929, 318
Show/Hide
|
C31H37N5O4
|
1
|
| 1 |
Ki = 835 nM
|
|
|
|
CP0479308
|
(1S,2S,5R)-methyl 8-(2-(3,4-dichlorophenyl)acetyl)-2-(pyrrolidin-1-yl)-6,8-diazabicyclo[3.2.2]nonane-6-carboxylate
Show/Hide
|
C21H27Cl2N3O3
|
1
|
| 1 |
Ki = 850 nM
|
|
|
|
CP0442033
|
US8846929, 24
Show/Hide
|
C24H34N4O
|
1
|
| 1 |
Ki = 852 nM
|
|
|
|
CP0558717
|
US8846929, 218
Show/Hide
|
C28H41N5O4
|
1
|
| 1 |
Ki = 863 nM
|
|
|
|
CP0443113
|
US8846929, 188
Show/Hide
|
C29H40N4O4
|
1
|
| 1 |
Ki = 871 nM
|
|
|
|
CP0524500
|
US8637502, 9
Show/Hide
|
C22H31N3O2
|
1
|
| 1 |
Ki = 880 nM
|
|
|
|
CP0450773
|
US8846929, 3
Show/Hide
|
C23H34N4O2
|
1
|
| 1 |
Ki = 888 nM
|
|
|
|
CP0433730
|
N,N-diethyl-4-[[(1S,5S)-4-phenyl-8-prop-2-enyl-6,8-diazabicyclo[3.2.2]non-3-en-6-yl]methyl]benzamide
Show/Hide
|
C28H35N3O
|
1
|
| 1 |
Ki = 890 nM
|
|
|
|
CP0470951
|
US8846929, 197
Show/Hide
|
C27H38N4O3
|
1
|
| 1 |
Ki = 890 nM
|
|
|
|
CP0399432
|
US8846929, 11
Show/Hide
|
C24H37N5O3S
|
1
|
| 1 |
Ki = 905 nM
|
|
|
|
CP0450784
|
US8846929, 314
Show/Hide
|
C32H38N4O4
|
1
|
| 1 |
Ki = 909 nM
|
|
|
|
CP0417987
|
(-)-1-[(1R,2R,5S)-6-Benzyl-2-(pyrrolidin-1-yl)-6,8-diazabicyclo[3.2.2]nonan-8-yl]-2-(3,4-dichlorophenyl)ethanone
Show/Hide
|
C26H31Cl2N3O
|
1
|
| 1 |
Ki = 920 nM
|
|
|
|
CP0545697
|
US8846929, 199
Show/Hide
|
C30H42N4O3
|
1
|
| 1 |
Ki = 920 nM
|
|
|
|
CP0372979
|
2-benzyl-1'-[4-(propan-2-yl)cyclohexyl]-2,3-dihydro-1H-spiro[isoquinoline-4,4'-piperidine]-3-one
Show/Hide
|
C29H38N2O
|
1
|
| 1 |
Ki = 928 nM
|
|
|
|
CP0510250
|
US8846929, 55
Show/Hide
|
C24H36N4O3
|
1
|
| 1 |
Ki = 929 nM
|
|
|
|
CP0542019
|
US8846929, 49
Show/Hide
|
C28H41N5O2
|
1
|
| 1 |
Ki = 971 nM
|
|
|
|
CP0510252
|
US8846929, 79
Show/Hide
|
C25H36N4O4
|
1
|
| 1 |
Ki = 994 nM
|
|
|
|
CP0569073
|
US8846929, 115
Show/Hide
|
C26H36N4O4
|
1
|
| 1 |
Ki = 998 nM
|
|
|
|
CP0168317
|
1-(4,4-bis(4-fluorophenyl)butyl)-4-(4-chloro-3-(trifluoromethyl)phenyl)piperidin-4-ol
Show/Hide
|
C28H27ClF5NO
|
1
|
| 1 |
Ki = 1000 nM
|
|
|
|
CP0403753
|
3-(1-benzyl-1,2,3,6-tetrahydropyridin-4-yl)-5-chloro-1H-indole
Show/Hide
|
C20H19ClN2
|
1
|
| 1 |
Ki = 1010 nM
|
|
|
|
CP0154285
|
1-[5,5-bis(4-fluorophenyl)pent-4-enyl]-4-[4-chloro-3-(trifluoromethyl)phenyl]piperidin-4-ol
Show/Hide
|
C29H27ClF5NO
|
1
|
| 1 |
Ki = 1021 nM
|
|
|
|
CP0954971
|
US9096606, 18
Show/Hide
|
C34H43N2O5+
|
1
|
| 1 |
Ki = 1031.97 nM
|
|
|
|
CP0919309
|
US8846929, 71
Show/Hide
|
C22H29N3O3
|
1
|
| 1 |
Ki = 1034 nM
|
|
|
|
CP0510248
|
US8846929, 28
Show/Hide
|
C27H38N4O4
|
1
|
| 1 |
Ki = 1038 nM
|
|
|
|
CP0394322
|
N,N-diethyl-4-[[(1S,4R,5S)-4-phenyl-8-prop-2-enyl-6,8-diazabicyclo[3.2.2]nonan-6-yl]methyl]benzamide
Show/Hide
|
C28H37N3O
|
1
|
| 1 |
Ki = 1100 nM
|
|
|
|
CP0405141
|
2-benzyl-1'-(4-tert-butylcyclohexyl)-7-fluoro-2,3-dihydro-1H-spiro[isoquinoline-4,4'-piperidine]-3-one
Show/Hide
|
C30H39FN2O
|
1
|
| 1 |
Ki = 1104 nM
|
|
|
|
CP0470333
|
US8846929, 235
Show/Hide
|
C23H31N3O3
|
1
|
| 1 |
Ki = 1116 nM
|
|
|
|
CP0503748
|
US8846929, 65
Show/Hide
|
C25H38N4O3
|
1
|
| 1 |
Ki = 1149 nM
|
|
|
|
CP0405143
|
1'-(4-tert-butylcyclohexyl)-7-fluoro-2-methyl-2,3-dihydro-1H-spiro[isoquinoline-4,4'-piperidine]-3-one
Show/Hide
|
C24H35FN2O
|
1
|
| 1 |
Ki = 1150 nM
|
|
|
|
CP0469759
|
US8846929, 176
Show/Hide
|
C30H42N4O3
|
1
|
| 1 |
Ki = 1153 nM
|
|
|
|
CP0446496
|
7-chloro-3-(1-(cyclooctylmethyl)piperidin-4-yl)-1H-indole
Show/Hide
|
C22H31ClN2
|
1
|
| 1 |
Ki = 1170 nM
|
|
|
|
CP0503756
|
US8846929, 54
Show/Hide
|
C24H36N4O3
|
1
|
| 1 |
Ki = 1195 nM
|
|
|
|
CP0464915
|
US8846929, 114
Show/Hide
|
C29H40N4O3
|
1
|
| 1 |
Ki = 1203 nM
|
|
|
|
CP0389012
|
N-[(4-anilino-1-benzylpiperidin-4-yl)methyl]-2-(diaminomethylideneamino)acetamide
Show/Hide
|
C22H30N6O
|
1
|
| 1 |
Ki = 1233 nM
|
|
|
|
CP0520567
|
US8846929, 33
Show/Hide
|
C24H35N5O3
|
1
|
| 1 |
Ki = 1282.6 nM
|
|
|
|
CP0442187
|
US8846929, 25
Show/Hide
|
C24H36N4O3
|
1
|
| 1 |
Ki = 1300 nM
|
|
|
|
CP0517946
|
US8637502, 66
Show/Hide
|
C20H28N4O2
|
1
|
| 1 |
Ki = 1317 nM
|
|
|
|
CP0082560
|
4-[4-chloro-3-(trifluoromethyl)phenyl]-1-(4,4-diphenylbutyl)piperidin-4-ol
Show/Hide
|
C28H29ClF3NO
|
1
|
| 1 |
Ki = 1328 nM
|
|
|
|
CP0543998
|
US8846929, 201
Show/Hide
|
C28H37N5O4
|
1
|
| 1 |
Ki = 1360 nM
|
|
|
|
CP0383805
|
(3aR,7aR)-3-[1-(1,2,3,4,4a,5,6,7,8,8a-decahydronaphthalen-2-yl)piperidin-4-yl]-3a,4,5,6,7,7a-hexahydro-1H-benzimidazol-2-one
Show/Hide
|
C22H37N3O
|
1
|
| 1 |
Ki = 1394 nM
|
|
|
|
CP0386894
|
N-[[1-benzyl-4-(naphthalen-1-ylmethyl)piperidin-4-yl]methyl]-2-(diaminomethylideneamino)acetamide
Show/Hide
|
C27H33N5O
|
1
|
| 1 |
Ki = 1470 nM
|
|
|
|
CP0442025
|
US8846929, 68
Show/Hide
|
C25H36N4O2
|
1
|
| 1 |
Ki = 1486 nM
|
|
|
|
CP0464045
|
US8846929, 191
Show/Hide
|
C27H37N5O4
|
1
|
| 1 |
Ki = 1493 nM
|
|
|
|
CP0083027
|
1-{3-[3-(tert-butyl) phenyl]-(1,2,4-triazol-4-yl) }-3-phenol
Show/Hide
|
C18H19N3O
|
1
|
| 1 |
Ki = 1500 nM
|
|
|
|
CP0417979
|
(+)-1-[(1S,2S,5R)-6-Benzyl-2-(pyrrolidin-1-yl)-6,8-diazabicyclo[3.2.2]nonan-8-yl]-2-(3,4-dichlorophenyl)ethanone
Show/Hide
|
C26H31Cl2N3O
|
1
|
| 1 |
Ki = 1510 nM
|
|
|
|
CP0412096
|
US9090618, ZA37
Show/Hide
|
C27H36N4O3
|
1
|
| 1 |
Ki = 1543 nM
|
|
|
|
CP0513748
|
US8846929, 296
Show/Hide
|
C25H31N3O3
|
1
|
| 1 |
Ki = 1547 nM
|
|
|
|
CP0426466
|
US8846929, 303
Show/Hide
|
C24H33N3O3
|
1
|
| 1 |
Ki = 1582 nM
|
|
|
|
CP0545896
|
US8846929, 270
Show/Hide
|
C28H25N3O3
|
1
|
| 1 |
Ki = 1600 nM
|
|
|
|
CP0554260
|
US8846929, 196
Show/Hide
|
C28H38N4O4
|
1
|
| 1 |
Ki = 1650 nM
|
|
|
|
CP0394295
|
N,N-diethyl-4-[[(1S,4S,5S)-4-phenyl-8-prop-2-enyl-6,8-diazabicyclo[3.2.2]nonan-6-yl]methyl]benzamide
Show/Hide
|
C28H37N3O
|
1
|
| 1 |
Ki = 1700 nM
|
|
|
|
CP0373072
|
(3aR,7aR)-1-(1-Cyclooctylmethyl-piperidin-4-yl)-octahydro-benzoimidazol-2-one
Show/Hide
|
C21H37N3O
|
1
|
| 1 |
Ki = 1701 nM
|
|
|
|
CP0198449
|
4-[4-chloro-3-(trifluoromethyl)phenyl]-1-[5-(4-fluorophenyl)pentyl]piperidin-4-ol
Show/Hide
|
C23H26ClF4NO
|
1
|
| 1 |
Ki = 1705 nM
|
|
|
|
CP0941773
|
US8846929, 317
Show/Hide
|
C26H34N8O2
|
1
|
| 1 |
Ki = 1720 nM
|
|
|
|
CP0491119
|
US8846929, 359
Show/Hide
|
C26H33N3O3
|
1
|
| 1 |
Ki = 1756 nM
|
|
|
|
CP0529481
|
US9290488, E54a
Show/Hide
|
C31H42N4O3
|
1
|
| 1 |
Ki = 1770 nM
|
|
|
|
CP0453003
|
3-(1-(1,2-dihydroacenaphthylen-1-yl)piperidin-4-yl)-5-fluoro-1H-indole
Show/Hide
|
C25H23FN2
|
1
|
| 1 |
Ki = 1890 nM
|
|
|
|
CP0458107
|
(R)-1-(3-(1-(cyclooctylmethyl)piperidin-4-yl)-5-fluoro-1H-indol-1-yl)-3-(dimethylamino)propan-2-ol
Show/Hide
|
C27H42FN3O
|
1
|
| 1 |
Ki = 1900 nM
|
|
|
|
CP0098923
|
(2S)-6-amino-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-methylpentanoyl]amino]hexanamide
Show/Hide
|
C42H68N14O8
|
1
|
| 1 |
Ki = 1900 nM
|
|
|
|
CP0372978
|
2-benzyl-7-fluoro-1'-[4-(propan-2-yl)cyclohexyl]-2,3-dihydro-1H-spiro[isoquinoline-4,4'-piperidine]-3-one
Show/Hide
|
C29H37FN2O
|
1
|
| 1 |
Ki = 1920 nM
|
|
|
|
CP0554261
|
US8846929, 231
Show/Hide
|
C27H38N4O4
|
1
|
| 1 |
Ki = 2032 nM
|
|
|
|
CP0470331
|
US8846929, 253
Show/Hide
|
C25H33N3O3
|
1
|
| 1 |
Ki = 2055 nM
|
|
|
|
CP0109897
|
US8846929, 362
Show/Hide
|
C26H33N3O3
|
1
|
| 1 |
Ki = 2280 nM
|
|
|
|
CP0409534
|
N,N-diethyl-4-[[(1S,4S,5S)-4-phenyl-8-propyl-6,8-diazabicyclo[3.2.2]nonan-6-yl]methyl]benzamide
Show/Hide
|
C28H39N3O
|
1
|
| 1 |
Ki = 2400 nM
|
|
|
|
CP0924804
|
US8846929, 237
Show/Hide
|
C24H33N3O3
|
1
|
| 1 |
Ki = 2473 nM
|
|
|
|
CP0436265
|
7-chloro-3-(1-(1,2-dihydroacenaphthylen-1-yl)piperidin-4-yl)-1H-indole
Show/Hide
|
C25H23ClN2
|
1
|
| 1 |
Ki = 2600 nM
|
|
|
|
CP0464036
|
US8846929, 124
Show/Hide
|
C29H35N5O3
|
1
|
| 1 |
Ki = 2600 nM
|
|
|
|
CP0198450
|
1-[5,5-bis(4-fluorophenyl)pentyl]-4-[4-chloro-3-(trifluoromethyl)phenyl]piperidin-4-ol
Show/Hide
|
C29H29ClF5NO
|
1
|
| 1 |
Ki = 2669 nM
|
|
|
|
CP0413438
|
US9145408, 360
Show/Hide
|
C25H31N3O3
|
1
|
| 1 |
Ki = 2691 nM
|
|
|
|
CP0491128
|
US8846929, 95
Show/Hide
|
C22H30N4O3
|
1
|
| 1 |
Ki = 2728 nM
|
|
|
|
CP0446331
|
3-(1-(1,2-dihydroacenaphthylen-1-yl)piperidin-4-yl)-1H-pyrrolo[2,3-b]pyridine
Show/Hide
|
C24H23N3
|
1
|
| 1 |
Ki = 2780 nM
|
|
|
|
CP0466570
|
US8846929, 106
Show/Hide
|
C25H34N4O3
|
1
|
| 1 |
Ki = 2840 nM
|
|
|
|
CP0205889
|
US8476271, 19
Show/Hide
|
C26H33N3O3
|
1
|
| 1 |
Ki = 2889 nM
|
|
|
|
CP0529290
|
US8846929, 320
Show/Hide
|
C25H29N3O3
|
1
|
| 1 |
Ki = 3090 nM
|
|
|
|
CP0248165
|
2-benzyl-5-(3-methoxyphenyl)-1,3-dihydroisoindole
Show/Hide
|
C22H21NO
|
1
|
| 1 |
Ki = 3182 nM
|
|
|
|
CP0559708
|
US8846929, 239
Show/Hide
|
C25H35N3O3
|
1
|
| 1 |
Ki = 3272 nM
|
|
|
|
CP0412571
|
US8846929, 228
Show/Hide
|
C29H41N5O5
|
1
|
| 1 |
Ki = 3320 nM
|
|
|
|
CP0470178
|
US9388162, 12
Show/Hide
|
C24H29NO7
|
1
|
| 1 |
Ki = 3410.66 nM
|
|
|
|
CP0372980
|
1'-(4-tert-butylcyclohexyl)-5-fluoro-2-methyl-2,3-dihydro-1H-spiro[isoquinoline-4,4'-piperidine]-3-one
Show/Hide
|
C24H35FN2O
|
1
|
| 1 |
Ki = 3600 nM
|
|
|
|
CP0960303
|
US9340542, 5
Show/Hide
|
C26H30N2O4
|
1
|
| 1 |
Ki = 3602 nM
|
|
|
|
CP0500713
|
1'-(4-tert-butylcyclohexyl)-7-fluoro-2,3-dihydro-1H-spiro[isoquinoline-4,4'-piperidine]-3-one
Show/Hide
|
C23H33FN2O
|
1
|
| 1 |
Ki = 3641 nM
|
|
|
|
CP0398314
|
N-[[1-benzyl-4-(3,5-dimethoxyanilino)piperidin-4-yl]methyl]-2-(diaminomethylideneamino)acetamide
Show/Hide
|
C24H34N6O3
|
1
|
| 1 |
Ki = 3678 nM
|
|
|
|
CP0437156
|
1'-[4-(propan-2-yl)cyclohexyl]-2,3-dihydro-1H-spiro[isoquinoline-4,4'-piperidine]-3-one
Show/Hide
|
C22H32N2O
|
1
|
| 1 |
Ki = 3827 nM
|
|
|
|
CP0405145
|
1'-(4-tert-butylcyclohexyl)-2,3-dihydro-1H-spiro[isoquinoline-4,4'-piperidine]-3-one
Show/Hide
|
C23H34N2O
|
1
|
| 1 |
Ki = 3844 nM
|
|
|
|
CP0442845
|
3-(1-(cyclooctylmethyl)piperidin-4-yl)-1H-pyrrolo[2,3-b]pyridine
Show/Hide
|
C21H31N3
|
1
|
| 1 |
Ki = 3890 nM
|
|
|
|
CP0450786
|
US8846929, 355
Show/Hide
|
C23H27N3O3
|
1
|
| 1 |
Ki = 3891 nM
|
|
|
|
CP0405147
|
7-fluoro-1'-[4-(propan-2-yl)cyclohexyl]-2,3-dihydro-1H-spiro[isoquinoline-4,4'-piperidine]-3-one
Show/Hide
|
C22H31FN2O
|
1
|
| 1 |
Ki = 3977 nM
|
|
|
|
CP0415883
|
4-[4-[1-[4-[1-[6-[(2-methylpropan-2-yl)oxycarbonylamino]hexyl]triazol-4-yl]butyl]piperidin-4-yl]phenyl]-7-[4-(trifluoromethyl)phenyl]naphthalene-2-carboxylic acid
Show/Hide
|
C46H54F3N5O4
|
1
|
| 1 |
Ki = 4060 nM
|
|
|
|
CP0551327
|
US8637502, 44
Show/Hide
|
C23H30N4O2
|
1
|
| 1 |
Ki = 4232 nM
|
|
|
|
CP0386588
|
2-(diaminomethylideneamino)-N-[(1,4-dibenzylpiperidin-4-yl)methyl]acetamide
Show/Hide
|
C23H31N5O
|
1
|
| 1 |
Ki = 4247 nM
|
|
|
|
CP0969803
|
US9340542, 6
Show/Hide
|
C25H29N3O3
|
1
|
| 1 |
Ki = 4285 nM
|
|
|
|
CP0446495
|
1-(1,2-dihydroacenaphthylen-1-yl)-4-(1-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)piperidin-3-ol
Show/Hide
|
C25H25N3O
|
1
|
| 1 |
Ki = 4300 nM
|
|
|
|
CP0450783
|
US8846929, 103
Show/Hide
|
C25H35N5O2
|
1
|
| 1 |
Ki = 4330 nM
|
|
|
|
CP0503747
|
US8846929, 64
Show/Hide
|
C25H33N5O2
|
1
|
| 1 |
Ki = 4359 nM
|
|
|
|
CP0557348
|
US8846929, 292
Show/Hide
|
C26H33N3O3
|
1
|
| 1 |
Ki = 4470 nM
|
|
|
|
CP0524297
|
US8846929, 89
Show/Hide
|
C26H36N4O3
|
1
|
| 1 |
Ki = 4490 nM
|
|
|
|
CP0561553
|
US9340542, 2
Show/Hide
|
C23H29N3O3
|
1
|
| 1 |
Ki = 4758 nM
|
|
|
|
CP0510247
|
US8846929, 335
Show/Hide
|
C26H35N3O3
|
1
|
| 1 |
Ki = 5154 nM
|
|
|
|
CP0478850
|
US9145408, 369
Show/Hide
|
C26H34N4O3
|
1
|
| 1 |
Ki = 5345 nM
|
|
|
|
CP0383584
|
US8846929, 104
Show/Hide
|
C26H37N5O3
|
1
|
| 1 |
Ki = 5350 nM
|
|
|
|
CP0543999
|
US8846929, 249
Show/Hide
|
C24H31N3O4
|
1
|
| 1 |
Ki = 6000 nM
|
|
|
|
CP0129542
|
US8476271, 97
Show/Hide
|
C25H31N3O3
|
1
|
| 1 |
Ki = 6143 nM
|
|
|
|
CP0453622
|
(3aR,7aR)-1-[1-(4-Isopropyl-cyclohexyl)-piperidin-4-yl]-octahydro-benzoimidazol-2-one
Show/Hide
|
C21H37N3O
|
1
|
| 1 |
Ki = 6212 nM
|
|
|
|
CP0962055
|
2-[(R)-[[(2S)-2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxy-2,6-dimethyl-phenyl)propanoyl]-methyl-amino]propanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-(2-furyl)methyl]prop-2-enamide
Show/Hide
|
C34H40N6O6
|
1
|
| 1 |
Ki = 6700 nM
|
|
|
|
CP0402513
|
US9090618, ZA25
Show/Hide
|
C31H45N5O2
|
1
|
| 1 |
Ki = 6800 nM
|
|
|
|
CP0462642
|
US8637502, 24
Show/Hide
|
C27H26N4O3
|
1
|
| 1 |
Ki = 6950 nM
|
|
|
|
CP0529483
|
US9290488, C20a(ii)
Show/Hide
|
C30H38N4O4
|
1
|
| 1 |
Ki = 7050 nM
|
|
|
|
CP0543359
|
2-[(R)-[[(2S)-2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]-methylamino]propanoyl]amino]-3-phenylpropanoyl]amino]-(furan-2-yl)methyl]prop-2-enamide
Show/Hide
|
C32H39N5O6
|
1
|
| 1 |
Ki = 8310 nM
|
|
|
|
CP0512279
|
US9340542, 3
Show/Hide
|
C23H29N3O3
|
1
|
| 1 |
Ki = 8406 nM
|
|
|
|
CP0962056
|
2-[(S)-[[(2S)-2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxy-2,6-dimethyl-phenyl)propanoyl]-methyl-amino]propanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-phenyl-methyl]prop-2-enamide
Show/Hide
|
C36H42N6O5
|
1
|
| 1 |
Ki = 8620 nM
|
|
|
|
CP0067293
|
1-{3-[4-(tert-butyl)phenyl]-5-[(4-N-methyl)piperazin-1-yl]-(1,2,4-triazol-4-yl)}-3-phenol
Show/Hide
|
C23H29N5O
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0075030
|
1-{3-[4-(tert-butyl)phenyl]-5-[2-(N,N-dimethylamino)ethyl]-(1,2,4-triazol-4-yl)}-3-phenol
Show/Hide
|
C22H28N4O
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0082069
|
1-[(3-naphthalen-2-yl)-5-N,N-dimethylamino-(1,2,4-triazol-4-yl) ]-3-phenol
Show/Hide
|
C20H18N4O
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0110347
|
4-[3-(4-tert-butylphenyl)-5-(dimethylamino)-1,2,4-triazol-4-yl]phenol
Show/Hide
|
C20H24N4O
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0134916
|
1-{3-[3-(tert-butyl) phenyl]-5-N,N-dimethylaminomethyl-(1,2,4-triazol-4-yl) }-3-phenol
Show/Hide
|
C21H26N4O
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0134941
|
1-[3-(4-biphenyl)-5-N,N-dimethylamino-(1,2,4-triazol-4-yl) ]-3-phenol
Show/Hide
|
C22H20N4O
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0160714
|
1-[3-(3-biphenyl)-5-N,N-dimethylamino-(1,2,4-triazol-4-yl) ]-3-phenol
Show/Hide
|
C22H20N4O
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0160715
|
1-{3-[3-(tert-butyl) phenyl]-5-N,N-dimethylamino-(1,2,4-triazol-4-yl) }-3-phenol
Show/Hide
|
C20H24N4O
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0180130
|
1-{3-[4-(tert-butyl) phenyl]-(1,2,4-triazol-4-yl) }-3-phenol
Show/Hide
|
C18H19N3O
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0185592
|
1-[(3-naphthalen-2-yl)-(1,2,4-triazol-4-yl) ]-3-phenol
Show/Hide
|
C18H13N3O
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0185594
|
1-[3-(4-biphenyl)-(1,2,4-triazol-4-yl) ]-3-phenol
Show/Hide
|
C20H15N3O
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0208947
|
1-{3-[3-(tert-butyl) phenyl]-(1,2,4-triazol-4-yl) }-3-methoxybenzene
Show/Hide
|
C19H21N3O
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0215389
|
1-{3-[4-(tert-butyl)phenyl]-5-N,N-dimethylamino-(1,2,4-triazol-4-yl)}-3-methoxybenzene
Show/Hide
|
C21H26N4O
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0215390
|
1-{3-[4-(tert-butyl) phenyl]-5-N,N-dimethylamino-(1,2,4-triazol-4-yl)}-3-phenol
Show/Hide
|
C20H24N4O
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0215402
|
1-[3-(3-biphenyl)-(1,2,4-triazol-4-yl) ]-3-phenol
Show/Hide
|
C20H15N3O
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0221707
|
1-{3-[4-(tert-butyl) phenyl]-5-N,N-dimethylaminomethyl-(1,2,4-triazol-4-yl)}-3-phenol
Show/Hide
|
C21H26N4O
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0320154
|
1-{3-[3-(tert-butyl) phenyl]-(1,2,4-triazol-4-yl) }-3-methoxybenzene
Show/Hide
|
C19H21N3O
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0038350
|
(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-6-amino-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-6-amino-2-[(2S)-2-[(2S)-2-{2-[(2S,3R)-2-[(2S)-2-(2-{2-[(2S)-2-amino-3-phenylpropanamido]acetamido}acetamido)-3-phenylpropanamido]-3-hydroxybutanamido]acetamido}propanamido]-5-carbamimidamidopentanamido]hexanamido]-3-hydroxypropanamido]propanamido]-5-carbamimidamidopentanamido]hexanamido]-4-methylpentanamido]propanamido]butanediamido]-4-carbamoylbutanoic acid
Show/Hide
|
C79H129N27O22
|
2
|
| 1 |
Ki > 10000 nM
|
|
|
| 2 |
Ki > 1000 nM
|
|
|
|
CP0405140
|
4-phenyl-1-[4-(propan-2-yl)cyclohexyl]piperidine-4-carboxamide
Show/Hide
|
C21H32N2O
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0431782
|
N-methyl-4-phenyl-1-[4-(propan-2-yl)cyclohexyl]piperidine-4-carboxamide
Show/Hide
|
C22H34N2O
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0500712
|
N-benzyl-4-phenyl-1-[4-(propan-2-yl)cyclohexyl]piperidine-4-carboxamide
Show/Hide
|
C28H38N2O
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0377993
|
(3aR,7aR)-1-Ethyl-3-[1-(4-isopropyl-cyclohexyl)-piperidin-4-yl]-octahydro-benzoimidazol-2-one
Show/Hide
|
C23H41N3O
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0410672
|
(3aR,7aR)-1-[1-(1,2,3,4,4a,5,6,7,8,8a-decahydronaphthalen-2-yl)piperidin-4-yl]-3-ethyl-3a,4,5,6,7,7a-hexahydrobenzimidazol-2-one
Show/Hide
|
C24H41N3O
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0448201
|
(3aR,7aR)-1-(1-Cyclooctylmethyl-piperidin-4-yl)-3-ethyl-octahydro-benzoimidazol-2-one
Show/Hide
|
C23H41N3O
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0002070
|
1-(1H-Indol-3-yl)-2-propanamine
Show/Hide
|
C11H14N2
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0002071
|
N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-N-prop-2-enylprop-2-en-1-amine
Show/Hide
|
C17H22N2O
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0635067
|
2-amino-6-chloro-3,4-dihydroquinazoline hydrochloride
Show/Hide
|
C8H9Cl2N3
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0202831
|
4-[4-chloro-3-(trifluoromethyl)phenyl]-1-[4-(4-methoxy-N-(4-methoxyphenyl)anilino)butyl]piperidin-4-ol
Show/Hide
|
C30H34ClF3N2O3
|
1
|
| 1 |
Ki = 10000 nM
|
|
|
|
CP0314578
|
4-[4-chloro-3-(trifluoromethyl)phenyl]-1-[4-(4-fluoro-N-(4-fluorophenyl)anilino)butyl]piperidin-4-ol
Show/Hide
|
C28H28ClF5N2O
|
1
|
| 1 |
Ki = 10000 nM
|
|
|
|
CP0235395
|
(S)-1-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionyl]-pyrrolidine-2-carboxylic acid [(S)-1-((S)-1-carbamoyl-2-phenyl-ethylcarbamoyl)-2-(1H-indol-3-yl)-ethyl]-amide
Show/Hide
|
C34H38N6O5
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0543360
|
2-[(R)-[[(2S)-2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]-methylamino]propanoyl]amino]-3-phenylpropanoyl]amino]-(furan-2-yl)methyl]prop-2-enamide
Show/Hide
|
C30H35N5O6
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1
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| 1 |
Ki > 10000 nM
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CP0567885
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2-[(S)-[[(2S)-2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]-methylamino]propanoyl]amino]-3-phenylpropanoyl]amino]-phenylmethyl]prop-2-enamide
Show/Hide
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C32H37N5O5
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1
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| 1 |
Ki > 10000 nM
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|
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CP0571667
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2-[(S)-[[(2S)-2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]-methylamino]propanoyl]amino]-3-phenylpropanoyl]amino]-phenylmethyl]prop-2-enamide
Show/Hide
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C34H41N5O5
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1
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| 1 |
Ki > 10000 nM
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CP0965088
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2-[(S)-[[(2S)-2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]-methyl-amino]propanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-phenyl-methyl]prop-2-enamide
Show/Hide
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C34H38N6O5
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1
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| 1 |
Ki > 10001 nM
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CP0950723
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2-[(R)-[[(2S)-2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]-methyl-amino]propanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-(2-furyl)methyl]prop-2-enamide
Show/Hide
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C32H36N6O6
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1
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| 1 |
Ki > 10002 nM
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CP0510257
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US8846929, 363
Show/Hide
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C27H33N3O3
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1
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| 1 |
Ki = 10240 nM
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CP0484464
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US8846929, 19
Show/Hide
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C29H36N4O
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1
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| 1 |
Ki = 11500 nM
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CP0529485
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US9388162, 18
Show/Hide
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C29H40N2O6
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1
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| 1 |
Ki = 15905.72 nM
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CP0533591
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US8846929, 286
Show/Hide
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C24H33N3O3
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1
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| 1 |
Ki = 16760 nM
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CP0466710
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US8846929, 111
Show/Hide
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C26H35N3O3
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1
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| 1 |
Ki = 19250 nM
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CP0491118
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US8846929, 323
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C25H31N3O3
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1
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| 1 |
Ki > 20000 nM
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CP0489626
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US9388162, 10
Show/Hide
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C25H31NO7
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1
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| 1 |
Ki > 20000 nM
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CP0493190
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US9388162, 13
Show/Hide
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C26H34N2O6
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1
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| 1 |
Ki > 20000 nM
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|
|
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CP0507282
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US9388162, 16
Show/Hide
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C28H36N2O6
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1
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| 1 |
Ki > 20000 nM
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|
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CP0441839
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(2S)-2-[[(2S)-2-acetamido-3-(1H-indol-3-yl)propanoyl]amino]-N-(2-amino-2-oxoethyl)-3-phenylpropanamide
Show/Hide
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C24H27N5O4
|
1
|
| 1 |
Ki = 33000 nM
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CP0389474
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(2R,5S,8R)-5-benzyl-2-(1H-indol-3-ylmethyl)-3,6,10,14-tetraoxo-1,4,7,11-tetrazacyclotetradecane-8-carboxamide
Show/Hide
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C27H30N6O5
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1
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| 1 |
Ki > 100000 nM
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CP0423727
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(2S)-2-[[(2R)-2-acetamido-3-(1H-indol-3-yl)propanoyl]amino]-3-phenylpropanamide
Show/Hide
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C22H24N4O3
|
1
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| 1 |
Ki > 100000 nM
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|
|
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CP0423729
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(2S)-2-[[(2R)-2-acetamido-3-(1H-indol-3-yl)propanoyl]amino]-N-(2-amino-2-oxoethyl)-3-phenylpropanamide
Show/Hide
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C24H27N5O4
|
1
|
| 1 |
Ki > 100000 nM
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|
|
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CP0856450
|
(R)-2-acetamido-6-amino-N-((S)-1-(2-amino-2-oxoethylamino)-1-oxo-3-phenylpropan-2-yl)hexanamide 2,2,2-trifluoroacetate
Show/Hide
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C21H30F3N5O6
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1
|
| 1 |
Ki > 100000 nM
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|
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CP0857908
|
(R)-2-acetamido-N-((S)-1-(2-amino-2-oxoethylamino)-1-oxo-3-phenylpropan-2-yl)-5-guanidinopentanamide 2,2,2-trifluoroacetate
Show/Hide
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C21H30F3N7O6
|
1
|
| 1 |
Ki > 100000 nM
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|
|
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CP0870555
|
(R)-2-acetamido-N-((S)-1-(2-amino-2-oxoethylamino)-1-oxo-3-phenylpropan-2-yl)-3-(1H-imidazol-5-yl)propanamide 2,2,2-trifluoroacetate
Show/Hide
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C21H25F3N6O6
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1
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| 1 |
Ki > 100000 nM
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|
|
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CP0877772
|
(R)-2-acetamido-6-amino-N-((S)-1-amino-1-oxo-3-phenylpropan-2-yl)hexanamide 2,2,2-trifluoroacetate
Show/Hide
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C19H27F3N4O5
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1
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| 1 |
Ki > 100000 nM
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CP0880822
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(R)-2-acetamido-N-((S)-1-amino-1-oxo-3-phenylpropan-2-yl)-5-guanidinopentanamide 2,2,2-trifluoroacetate
Show/Hide
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C19H27F3N6O5
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1
|
| 1 |
Ki > 100000 nM
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|
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CP0911598
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(R)-2-acetamido-N-((S)-1-amino-1-oxo-3-phenylpropan-2-yl)-3-(1H-imidazol-5-yl)propanamide 2,2,2-trifluoroacetate
Show/Hide
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C19H22F3N5O5
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1
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| 1 |
Ki > 100000 nM
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|
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CP0379938
|
(3S,6R,12S)-3-benzyl-12-[(4-hydroxyphenyl)methyl]-6-(1H-indol-3-ylmethyl)-1,4,7,10,13-pentazacyclopentadecane-2,5,8,11,14-pentone
Show/Hide
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C33H34N6O6
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1
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| 1 |
Ki > 100000 nM
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|
|
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CP0379941
|
(2S)-2-[[(2R)-2-acetamido-3-(7-bromo-2-methyl-1H-indol-3-yl)propanoyl]amino]-N-(2-amino-2-oxoethyl)-3-phenylpropanamide
Show/Hide
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C25H28BrN5O4
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1
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| 1 |
Ki > 100000 nM
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|
|
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CP0396830
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(2S)-2-[[(2R)-2-acetamido-3-(7-bromo-1H-indol-3-yl)propanoyl]amino]-N-(2-amino-2-oxoethyl)-3-phenylpropanamide
Show/Hide
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C24H26BrN5O4
|
1
|
| 1 |
Ki > 100000 nM
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|
|
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CP0411912
|
(2S)-2-[[(2R)-2-acetamido-3-(5-methyl-1H-indol-3-yl)propanoyl]amino]-N-(2-amino-2-oxoethyl)-3-phenylpropanamide
Show/Hide
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C25H29N5O4
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1
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| 1 |
Ki > 100000 nM
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|
|
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CP0487945
|
(2S)-2-[[(2R)-2-acetamido-3-(5-bromo-1H-indol-3-yl)propanoyl]amino]-N-(2-amino-2-oxoethyl)-3-phenylpropanamide
Show/Hide
|
C24H26BrN5O4
|
1
|
| 1 |
Ki > 100000 nM
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|
|
|
CP0490600
|
(2S)-2-[[(2R)-2-acetamido-3-(2-methyl-1H-indol-3-yl)propanoyl]amino]-N-(2-amino-2-oxoethyl)-3-phenylpropanamide
Show/Hide
|
C25H29N5O4
|
1
|
| 1 |
Ki > 100000 nM
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|
|
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CP0494500
|
(2S)-2-[[(2R)-2-acetamido-3-(5-nitro-1H-indol-3-yl)propanoyl]amino]-N-(2-amino-2-oxoethyl)-3-phenylpropanamide
Show/Hide
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C24H26N6O6
|
1
|
| 1 |
Ki > 100000 nM
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|
|
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CP0873058
|
(S)-2-amino-N-(((R)-3-((S)-1-((S)-1-amino-1-oxo-3-phenylpropan-2-ylamino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl)-2,4-dioxooxazolidin-5-yl)methyl)-3-(4-hydroxyphenyl)propanamide
Show/Hide
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C33H34N6O7
|
1
|
| 1 |
Ki > 100000 nM
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|
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CP0907830
|
(S)-2-amino-N-(((R)-3-((R)-1-((S)-1-amino-1-oxo-3-phenylpropan-2-ylamino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl)-2,4-dioxooxazolidin-5-yl)methyl)-3-(4-hydroxyphenyl)propanamide
Show/Hide
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C33H34N6O7
|
1
|
| 1 |
Ki > 100000 nM
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|
|
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CP0924851
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(S)-2-amino-N-(((S)-3-((R)-1-((S)-1-amino-1-oxo-3-phenylpropan-2-ylamino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl)-2,4-dioxooxazolidin-5-yl)methyl)-3-(4-hydroxyphenyl)propanamide
Show/Hide
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C33H34N6O7
|
1
|
| 1 |
Ki > 100000 nM
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|
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CP0421304
|
(7S,10S,13R)-10-benzyl-7-(1H-indol-3-ylmethyl)-1,5,8,11-tetrazabicyclo[11.3.0]hexadecane-2,6,9,12-tetrone
Show/Hide
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C28H31N5O4
|
1
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| 1 |
Ki > 100000 nM
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CP0434119
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(8S,11S,14R)-11-benzyl-8-(1H-indol-3-ylmethyl)-1,6,9,12-tetrazabicyclo[12.3.0]heptadecane-2,7,10,13-tetrone
Show/Hide
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C29H33N5O4
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1
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| 1 |
Ki > 100000 nM
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|
|
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CP0434498
|
(3R,6S,9S,12R)-9-benzyl-6-(1H-indol-3-ylmethyl)-3-methyl-1,4,7,10-tetrazabicyclo[10.3.0]pentadecane-2,5,8,11-tetrone
Show/Hide
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C28H31N5O4
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1
|
| 1 |
Ki > 100000 nM
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|
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CP0460556
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(3S,6S,9S,12R)-3,9-dibenzyl-6-[(1-methylindol-3-yl)methyl]-1,4,7,10-tetrazabicyclo[10.3.0]pentadecane-2,5,8,11-tetrone
Show/Hide
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C35H37N5O4
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1
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| 1 |
Ki > 100000 nM
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|
|
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CP0475188
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(3S,6S,9R,12R)-9-benzyl-6-(1H-indol-3-ylmethyl)-3-methyl-1,4,7,10-tetrazabicyclo[10.3.0]pentadecane-2,5,8,11-tetrone
Show/Hide
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C28H31N5O4
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1
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| 1 |
Ki > 100000 nM
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CP0532891
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(3S,6R,9S,12R)-3,9-dibenzyl-6-[(1-methylindol-3-yl)methyl]-1,4,7,10-tetrazabicyclo[10.3.0]pentadecane-2,5,8,11-tetrone
Show/Hide
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C35H37N5O4
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1
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| 1 |
Ki > 100000 nM
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CP0376883
|
methyl 1-[4-[2-(4-methylpiperazin-1-yl)benzimidazol-1-yl]piperidin-1-yl]cyclooctane-1-carboxylate
Show/Hide
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C27H41N5O2
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1
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| 1 |
Ki > 570 nM
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CP0377809
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(1-{4-[2-(4-Chlorophenyl)-1H-benzimidazol-1-yl]piperidin-1-yl}cyclooctyl)methanol
Show/Hide
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C27H34ClN3O
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1
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| 1 |
Ki > 570 nM
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CP0393713
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1-{4-[2-(4-Methylpiperazin-1-yl)-1H-benzimidazol-1-yl]-piperidin-1-yl}cyclooctanecarboxylic acid
Show/Hide
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C26H39N5O2
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1
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| 1 |
Ki > 570 nM
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|
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CP0145209
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[1-[4-[2-(2,3,3a,4,6,6a-hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl)benzimidazol-1-yl]piperidin-1-yl]cyclooctyl]methanol
Show/Hide
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C27H41N5O
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1
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| 1 |
Ki > 577 nM
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CP0372529
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(+)-1-{(1S,2S,5R)-8-[2-(3,4-Dichlorophenyl)acetyl]-2-(pyrrolidin-1-yl)-6,8-diazabicyclo[3.2.2]nonan-8-yl}propan-1-one
Show/Hide
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C22H29Cl2N3O2
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1
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| 1 |
Ki > 1000 nM
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CP0390914
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(1R,2R,5S)-methyl 8-(2-(3,4-dichlorophenyl)acetyl)-2-(pyrrolidin-1-yl)-6,8-diazabicyclo[3.2.2]nonane-6-carboxylate
Show/Hide
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C21H27Cl2N3O3
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1
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| 1 |
Ki > 1000 nM
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CP0390917
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(-)-1-{(1R,2R,5S)-8-[2-(3,4-Dichlorophenyl)acetyl]-2-(pyrrolidin-1-yl)-6,8-diazabicyclo[3.2.2]nonan-8-yl}propan-1-one
Show/Hide
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C22H29Cl2N3O2
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1
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| 1 |
Ki > 1000 nM
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CP0390920
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(-)-1-{(1R,2S,5S)-8-[2-(3,4-Dichlorophenyl)acetyl]-2-(pyrrolidin-1-yl)-6,8-diazabicyclo[3.2.2]nonan-8-yl}propan-1-one
Show/Hide
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C22H29Cl2N3O2
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1
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| 1 |
Ki > 1000 nM
|
|
|
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CP0390922
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(-)-Methyl(1R,2S,5S)-8-[2-(3,4-Dichlorophenyl)acetyl]-2-(pyrrolidin-1-yl)-6,8-diazabicyclo[3.2.2]nonane-6-carboxylate
Show/Hide
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C21H27Cl2N3O3
|
1
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| 1 |
Ki > 1000 nM
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|
|
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CP0475786
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(-)-1-[(1R,2S,5S)-6-Benzyl-2-(pyrrolidin-1-yl)-6,8-diazabicyclo-[3.2.2]nonan-8-yl]-2-(3,4-dichlorophenyl)ethanone
Show/Hide
|
C26H31Cl2N3O
|
1
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| 1 |
Ki > 1000 nM
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|
|
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CP0394000
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3-(1-(1,2-dihydroacenaphthylen-1-yl)piperidin-4-yl)-6-fluoro-1H-indole
Show/Hide
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C25H23FN2
|
1
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| 1 |
Ki > 5000 nM
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CP0395364
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1-((R)-3-amino-2-hydroxypropyl)-3-(1-(1,2-dihydroacenaphthylen-1-yl)-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole-5-carbonitrile
Show/Hide
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C29H28N4O
|
1
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| 1 |
Ki > 5000 nM
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|
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CP0395365
|
3-(1-(1,2-dihydroacenaphthylen-1-yl)-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole-5-carbonitrile
Show/Hide
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C26H21N3
|
1
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| 1 |
Ki > 5000 nM
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CP0428049
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1-(1,2-dihydroacenaphthylen-1-yl)-4-(1-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)piperidin-3-yl acetate
Show/Hide
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C27H27N3O2
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1
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| 1 |
Ki > 5000 nM
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CP0428067
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3-(1-(cyclohexylmethyl)piperidin-4-yl)-1H-pyrrolo[2,3-b]pyridine
Show/Hide
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C19H27N3
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1
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| 1 |
Ki > 5000 nM
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CP0436267
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2-(3-(1-(1,2-dihydroacenaphthylen-1-yl)piperidin-4-yl)-1H-pyrrolo[2,3-b]pyridin-1-yl)ethanol
Show/Hide
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C26H27N3O
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1
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| 1 |
Ki > 5000 nM
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CP0446330
|
3-(1-(1,2-dihydroacenaphthylen-1-yl)piperidin-4-yl)-1-methyl-1H-pyrrolo[2,3-b]pyridine
Show/Hide
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C25H25N3
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1
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| 1 |
Ki > 5000 nM
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CP0446332
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3-(1-(4-phenoxybenzyl)piperidin-4-yl)-1H-pyrrolo[2,3-b]pyridine
Show/Hide
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C25H25N3O
|
1
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| 1 |
Ki > 5000 nM
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|
|
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CP0453006
|
3-(1-(1,2-dihydroacenaphthylen-1-yl)-1,2,3,6-tetrahydropyridin-4-yl)-6-fluoro-1H-indole
Show/Hide
|
C25H21FN2
|
1
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| 1 |
Ki > 5000 nM
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|
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CP0458106
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1-benzyl-6-chloro-3-(1-(1,2-dihydroacenaphthylen-1-yl)piperidin-4-yl)-1H-indole
Show/Hide
|
C32H29ClN2
|
1
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| 1 |
Ki > 5000 nM
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|
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CP0464515
|
(4-(1H-pyrrolo[2,3-b]pyridin-3-yl)piperidin-1-yl)(4-tert-butylcyclohexyl)methanone
Show/Hide
|
C23H33N3O
|
1
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| 1 |
Ki > 5000 nM
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|
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CP0496761
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3-(1-hexylpiperidin-4-yl)-1H-pyrrolo[2,3-b]pyridine
Show/Hide
|
C18H27N3
|
1
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| 1 |
Ki > 5000 nM
|
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CP0511035
|
(2R)-1-(3-(1-(1,2-dihydroacenaphthylen-1-yl)piperidin-4-yl)-6-fluoro-1H-indol-1-yl)-3-(dimethylamino)propan-2-ol
Show/Hide
|
C30H34FN3O
|
1
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| 1 |
Ki > 5000 nM
|
|
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CP0477339
|
N-[(3-methoxythiophen-2-yl)methyl]-2-[(8R)-8-pyridin-2-yl-6-oxaspiro[4.5]decan-8-yl]ethanamine
Show/Hide
|
C22H30N2O2S
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1
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| 1 |
Ki < 10000 nM
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