General Information of the Compound
Compound ID
CP0894633
Compound Name
17-cyclopropylmethyl-16-methyl-4,13-di(4-methylhexahydro-1-pyrazinyl)-(16R)-17-azatetracyclo[7.6.2.02,7.010,15]heptadeca-2(7),3,5,12,14-pentaene
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Structure
Formula
C31H43N5
Molecular Weight
485.72
Canonical SMILES
C[C@@H]1[C@H]2c3cc(N4CCN(C)CC4)ccc3C[C@@H](c3ccc(N4CCN(C)CC4)cc32)N1CC1CC1
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InChI
InChI=1S/C31H43N5/c1-22-31-28-19-25(34-14-10-32(2)11-15-34)7-6-24(28)18-30(36(22)21-23-4-5-23)27-9-8-26(20-29(27)31)35-16-12-33(3)13-17-35/h6-9,19-20,22-23,30-31H,4-5,10-18,21H2,1-3H3/t22-,30+,31+/m1/s1
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InChIKey
IXLMHBQYLIJKQI-OJXBSAKDSA-N
Physicochemical Property
logP
4.0334
Rotatable Bonds
4
Heavy Atom Count
36
Polar Areas
16.2
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
5
Complexity
36

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 122197498
ChEMBL ID
CHEMBL3707088
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01200, Delta-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 2040 nM
   TI
   LI
   LO
   TS
Protein ID: PT00983, Kappa-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 1600 nM
   TI
   LI
   LO
   TS
Protein ID: PT01515, Mu-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 690 nM
   TI
   LI
   LO
   TS