Bioactivity Information

Brief Information of the Compound and Protein

Compound Name

Compound Info

N-methyl-2-phenyl-N-[(5R,7S,8S)-7-(pyrrolidin-1-yl)-1-oxaspiro[4.5]decan-8-yl]acetamide

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PubChem ID

CID: 105104

SID: 50093889

Canonical SMILES	CN([C@H]1CC[C@@]2(CCCO2)C[C@@H]1N1CCCC1)C(=O)Cc1ccccc1 Show/Hide
Compound Formula	C22H32N2O2

Compound Structure

Protein Name

Protein Info

Kappa-type opioid receptor

Protein Classification

Membrane receptor

Family A G protein-coupled receptor

Peptide receptor (family A GPCR)

Short peptide receptor (family A GPCR)

Opioid receptor

Uniprot ID

P41145

Gene Name

OPRK1

Table of Molecular Bioactivities Related to the Compound and Protein

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000011	CHO Cell Line Info	Cricetulus griseus (Chinese hamster)	11
1	EC50 = 0.8 nM	TI LI LO TS
2	EC50 = 12.5 nM	TI LI LO TS
3	EC50 = 26.1 nM	TI LI LO TS
4	EC50 = 28.1 nM	TI LI LO TS
5	EC50 = 60.14 nM	TI LI LO TS
6	EC50 = 207 nM	TI LI LO TS
7	Ki = 0.3 nM	TI LI LO TS
8	Ki = 1.05 nM	TI LI LO TS
9	Ki = 1.1 nM	TI LI LO TS
10	Ki = 1.6 nM	TI LI LO TS
11	Ki = 3.5 nM	TI LI LO TS
CL000006	HEK293 Cell Line Info	Homo sapiens (Human)	7
1	EC50 = 5.3 nM	TI LI LO TS
2	EC50 = 12 nM	TI LI LO TS
3	EC50 = 80 nM	TI LI LO TS
4	EC50 = 534 nM	TI LI LO TS
5	ED50 = 24 nM	TI LI LO TS
6	IC50 = 2 nM	TI LI LO TS
7	IC50 = 8 nM	TI LI LO TS

Biochemical Assays