General Information of the Compound
Compound ID
CP0962091
Compound Name
US9221831, 54
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Structure
Formula
C34H41N5O4
Molecular Weight
583.733
Canonical SMILES
COc1ccc2c3c1O[C@H]1[C@@]4(OC)CC[C@@]5(C[C@@H]4COCc4ccc(Cc6nn[nH]n6)cc4)[C@@H](C2)N(CC2CC2)CC[C@]315
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InChI
InChI=1S/C34H41N5O4/c1-40-26-10-9-24-16-27-32-11-12-34(41-2,31-33(32,29(24)30(26)43-31)13-14-39(27)18-22-5-6-22)25(17-32)20-42-19-23-7-3-21(4-8-23)15-28-35-37-38-36-28/h3-4,7-10,22,25,27,31H,5-6,11-20H2,1-2H3,(H,35,36,37,38)/t25-,27-,31-,32-,33+,34-/m1/s1
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InChIKey
DUVPACRADXQHNE-KRSIGYQBSA-N
Physicochemical Property
logP
4.2404
Rotatable Bonds
10
Heavy Atom Count
43
Polar Areas
94.62
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
8
Complexity
43

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 89978562
ChEMBL ID
CHEMBL4111263
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00983, Kappa-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 180.85 nM
   TI
   LI
   LO
   TS