General Information of the Compound
Compound ID
CP0436411
Compound Name
2-[[4-[(6-aminohexylamino)methyl]phenoxy]methyl]-N-(4-amino-2-methylquinolin-6-yl)benzamide
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Structure
Formula
C31H37N5O2
Molecular Weight
511.67
Canonical SMILES
Cc1cc(N)c2cc(NC(=O)c3ccccc3COc3ccc(CNCCCCCCN)cc3)ccc2n1
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InChI
InChI=1S/C31H37N5O2/c1-22-18-29(33)28-19-25(12-15-30(28)35-22)36-31(37)27-9-5-4-8-24(27)21-38-26-13-10-23(11-14-26)20-34-17-7-3-2-6-16-32/h4-5,8-15,18-19,34H,2-3,6-7,16-17,20-21,32H2,1H3,(H2,33,35)(H,36,37)
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InChIKey
QAGXUEMUOSEVRU-UHFFFAOYSA-N
Physicochemical Property
logP
5.56542
Rotatable Bonds
13
Heavy Atom Count
38
Polar Areas
115.29
Hydrogen Bond Donor Count
4
Hydrogen Bond Acceptor Count
6
Complexity
38

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 52915518
SID: 123051717
ChEMBL ID
CHEMBL1760025
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00983, Kappa-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 1222 nM
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   LI
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   TS
Protein ID: PT01515, Mu-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 5999 nM
   TI
   LI
   LO
   TS
Protein ID: PT01360, Nociceptin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 1106.7 nM
   TI
   LI
   LO
   TS