General Information of the Compound
Compound ID
CP0458882
Compound Name
2-[[4-[(4-aminobutylamino)methyl]phenoxy]methyl]-N-(4-amino-2-methylquinolin-6-yl)benzamide
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Structure
Formula
C29H33N5O2
Molecular Weight
483.616
Canonical SMILES
Cc1cc(N)c2cc(NC(=O)c3ccccc3COc3ccc(CNCCCCN)cc3)ccc2n1
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InChI
InChI=1S/C29H33N5O2/c1-20-16-27(31)26-17-23(10-13-28(26)33-20)34-29(35)25-7-3-2-6-22(25)19-36-24-11-8-21(9-12-24)18-32-15-5-4-14-30/h2-3,6-13,16-17,32H,4-5,14-15,18-19,30H2,1H3,(H2,31,33)(H,34,35)
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InChIKey
CMFMGQWSFBZJHX-UHFFFAOYSA-N
Physicochemical Property
logP
4.78522
Rotatable Bonds
11
Heavy Atom Count
36
Polar Areas
115.29
Hydrogen Bond Donor Count
4
Hydrogen Bond Acceptor Count
6
Complexity
36

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 52915516
SID: 123051715
ChEMBL ID
CHEMBL1762406
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00983, Kappa-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 4257 nM
   TI
   LI
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   TS
Protein ID: PT01515, Mu-type opioid receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 5333 nM
   TI
   LI
   LO
   TS
Protein ID: PT01360, Nociceptin receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 799.8 nM
   TI
   LI
   LO
   TS