| Compound ID |
Compound Name |
Compound Formula |
|
CP0415486
|
[(1R,2R,6R,10S,11R,15S,17R)-13-benzyl-6-hydroxy-4,17-dimethyl-5-oxo-15-prop-1-en-2-yl-12,14,18-trioxapentacyclo[11.4.1.01,10.02,6.011,15]octadeca-3,8-dien-8-yl]methyl 2-[4-(methanesulfonamido)-3-methoxyphenyl]acetate
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|
C38H43NO10S
|
1
|
| 1 |
EC50 = 0.106 nM
|
|
|
|
CP0222429
|
RESINIFERATOXIN
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|
C37H40O9
|
3
|
| 1 |
EC50 = 0.27 nM
|
|
|
| 2 |
Ki = 0.043 nM
|
|
|
| 3 |
Ki = 0.13 nM
|
|
|
|
CP0410045
|
[(2R,6R,10S,15S,17R)-13-benzyl-6-hydroxy-4,17-dimethyl-5-oxo-15-prop-1-en-2-yl-12,14,18-trioxapentacyclo[11.4.1.01,10.02,6.011,15]octadeca-3,8-dien-8-yl]methyl 2-(4-amino-3-methoxyphenyl)acetate
Show/Hide
|
C37H41NO8
|
2
|
| 1 |
EC50 = 0.46 nM
|
|
|
| 2 |
Ki = 0.13 nM
|
|
|
|
CP0517120
|
[(2R,6R,10S,15S,17R)-13-benzyl-6-hydroxy-4,17-dimethyl-5-oxo-15-prop-1-en-2-yl-12,14,18-trioxapentacyclo[11.4.1.01,10.02,6.011,15]octadeca-3,8-dien-8-yl]methyl 2-(4-amino-3-fluoro-5-methoxyphenyl)acetate
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|
C37H40FNO8
|
2
|
| 1 |
EC50 = 1.14 nM
|
|
|
| 2 |
Ki = 0.7 nM
|
|
|
|
CP0375075
|
[(1R,2R,6R,10S,11R,15S,17R)-13-benzyl-6-hydroxy-4,17-dimethyl-5-oxo-15-prop-1-en-2-yl-12,14,18-trioxapentacyclo[11.4.1.01,10.02,6.011,15]octadeca-3,8-dien-8-yl]methyl 2-[4-(methanesulfonamido)phenyl]acetate
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|
C37H41NO9S
|
1
|
| 1 |
EC50 = 1.78 nM
|
|
|
|
CP0415499
|
[(1R,2R,6R,10S,11R,15S,17R)-13-benzyl-6-hydroxy-4,17-dimethyl-5-oxo-15-prop-1-en-2-yl-12,14,18-trioxapentacyclo[11.4.1.01,10.02,6.011,15]octadeca-3,8-dien-8-yl]methyl 2-(2,4-difluorophenyl)acetate
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|
C36H36F2O7
|
1
|
| 1 |
EC50 = 1.8 nM
|
|
|
|
CP0447073
|
(4-amino-3-methoxyphenyl) [(1R,2R,6R,10S,11R,13S,15R,17R)-13-benzyl-6-hydroxy-4,17-dimethyl-5-oxo-15-prop-1-en-2-yl-12,14,18-trioxapentacyclo[11.4.1.01,10.02,6.011,15]octadeca-3,8-dien-8-yl]methyl carbonate
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|
C36H39NO9
|
2
|
| 1 |
EC50 = 1.84 nM
|
|
|
| 2 |
Ki = 0.58 nM
|
|
|
|
CP0373235
|
[(2R,6R,10S,15S,17R)-13-benzyl-6-hydroxy-4,17-dimethyl-5-oxo-15-prop-1-en-2-yl-12,14,18-trioxapentacyclo[11.4.1.01,10.02,6.011,15]octadeca-3,8-dien-8-yl]methyl 2-(3-fluoro-4-hydroxy-5-methoxyphenyl)acetate
Show/Hide
|
C37H39FO9
|
2
|
| 1 |
EC50 = 1.88 nM
|
|
|
| 2 |
Ki = 0.26 nM
|
|
|
|
CP0415485
|
[(1R,2R,6R,10S,11R,15S,17R)-13-benzyl-6-hydroxy-4,17-dimethyl-5-oxo-15-prop-1-en-2-yl-12,14,18-trioxapentacyclo[11.4.1.01,10.02,6.011,15]octadeca-3,8-dien-8-yl]methyl 2-(3-fluorophenyl)acetate
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|
C36H37FO7
|
1
|
| 1 |
EC50 = 1.92 nM
|
|
|
|
CP0326468
|
2,2-Dimethyl-propionic acid 2-(3,4-dimethyl-benzyl)-3-[3-(4-hydroxy-3-methoxy-benzyl)-thioureido]-propyl ester
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|
C26H36N2O4S
|
2
|
| 1 |
EC50 = 1.97 nM
|
|
|
| 2 |
Ki = 17.4 nM
|
|
|
|
CP0424008
|
[(1R,2R,6R,10S,11R,15S,17R)-13-benzyl-6-hydroxy-4,17-dimethyl-5-oxo-15-prop-1-en-2-yl-12,14,18-trioxapentacyclo[11.4.1.01,10.02,6.011,15]octadeca-3,8-dien-8-yl]methyl 2-[3-fluoro-4-(methanesulfonamido)phenyl]acetate
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|
C37H40FNO9S
|
1
|
| 1 |
EC50 = 2.45 nM
|
|
|
|
CP0372290
|
1-(4-tert-Butyl-benzyl)-3-(4-hydroxy-3-methoxy-benzyl)-thiourea
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|
C20H26N2O2S
|
4
|
| 1 |
EC50 = 2.5 nM
|
|
|
| 2 |
EC50 = 2.6 nM
|
|
|
| 3 |
Ki = 58.6 nM
|
|
|
| 4 |
Ki = 59 nM
|
|
|
|
CP0434050
|
2,2-Dimethyl-propionic acid 2-(4-tert-butyl-benzyl)-3-[3-(4-hydroxy-3-methoxy-benzyl)-thioureido]-propyl ester
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|
C28H40N2O4S
|
2
|
| 1 |
EC50 = 2.83 nM
|
|
|
| 2 |
Ki = 6.35 nM
|
|
|
|
CP0397472
|
(4-amino-3-fluoro-5-methoxyphenyl) [(1R,2R,6R,10S,11R,13S,15R,17R)-13-benzyl-6-hydroxy-4,17-dimethyl-5-oxo-15-prop-1-en-2-yl-12,14,18-trioxapentacyclo[11.4.1.01,10.02,6.011,15]octadeca-3,8-dien-8-yl]methyl carbonate
Show/Hide
|
C36H38FNO9
|
2
|
| 1 |
EC50 = 3.17 nM
|
|
|
| 2 |
Ki = 2.21 nM
|
|
|
|
CP0459798
|
[(1R,2R,6R,10S,11R,15S,17R)-13-benzyl-6-hydroxy-4,17-dimethyl-5-oxo-15-prop-1-en-2-yl-12,14,18-trioxapentacyclo[11.4.1.01,10.02,6.011,15]octadeca-3,8-dien-8-yl]methyl 2-(4-fluorophenyl)acetate
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|
C36H37FO7
|
1
|
| 1 |
EC50 = 3.88 nM
|
|
|
|
CP0398040
|
[2-[(4-tert-butylphenyl)methyl]-3-[[2-(4-hydroxy-3-methoxyphenyl)acetyl]amino]propyl] 2,2-dimethylpropanoate
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|
C28H39NO5
|
2
|
| 1 |
EC50 = 4.08 nM
|
|
|
| 2 |
Ki = 13.1 nM
|
|
|
|
CP0462377
|
[(1R,2R,6R,10S,11R,15S,17R)-13-benzyl-6-hydroxy-4,17-dimethyl-5-oxo-15-prop-1-en-2-yl-12,14,18-trioxapentacyclo[11.4.1.01,10.02,6.011,15]octadeca-3,8-dien-8-yl]methyl 2-(2,5-difluorophenyl)acetate
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|
C36H36F2O7
|
1
|
| 1 |
EC50 = 4.21 nM
|
|
|
|
CP0386212
|
[(1R,2R,6R,10S,11R,13S,15R,17R)-13-benzyl-6-hydroxy-4,17-dimethyl-5-oxo-15-prop-1-en-2-yl-12,14,18-trioxapentacyclo[11.4.1.01,10.02,6.011,15]octadeca-3,8-dien-8-yl]methyl [4-(methanesulfonamido)-3-methoxyphenyl] carbonate
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|
C37H41NO11S
|
2
|
| 1 |
EC50 = 4.62 nM
|
|
|
| 2 |
Ki = 1.28 nM
|
|
|
|
CP0510054
|
[(1R,2R,6R,10S,11R,15S,17R)-13-benzyl-6-hydroxy-4,17-dimethyl-5-oxo-15-prop-1-en-2-yl-12,14,18-trioxapentacyclo[11.4.1.01,10.02,6.011,15]octadeca-3,8-dien-8-yl]methyl 2-(2-fluorophenyl)acetate
Show/Hide
|
C36H37FO7
|
1
|
| 1 |
EC50 = 4.65 nM
|
|
|
|
CP0404349
|
[(1R,2R,6R,10S,11R,13S,15R,17R)-13-benzyl-6-hydroxy-4,17-dimethyl-5-oxo-15-prop-1-en-2-yl-12,14,18-trioxapentacyclo[11.4.1.01,10.02,6.011,15]octadeca-3,8-dien-8-yl]methyl (3-fluoro-4-hydroxy-5-methoxyphenyl) carbonate
Show/Hide
|
C36H37FO10
|
2
|
| 1 |
EC50 = 4.97 nM
|
|
|
| 2 |
Ki = 1.17 nM
|
|
|
|
CP0459799
|
[(1R,2R,6R,10S,11R,15S,17R)-13-benzyl-6-hydroxy-4,17-dimethyl-5-oxo-15-prop-1-en-2-yl-12,14,18-trioxapentacyclo[11.4.1.01,10.02,6.011,15]octadeca-3,8-dien-8-yl]methyl 2-(3,4-difluorophenyl)acetate
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|
C36H36F2O7
|
1
|
| 1 |
EC50 = 5.5 nM
|
|
|
|
CP0399727
|
2-(3-(4-hydroxy-3-methoxybenzyl)thioureido)-3-(4-tert-butylphenyl)propyl pivalate
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|
C27H38N2O4S
|
2
|
| 1 |
EC50 = 5.7 nM
|
|
|
| 2 |
Ki = 34.6 nM
|
|
|
|
CP0470505
|
[(2R,6R,10S,15S,17R)-13-benzyl-6-hydroxy-4,17-dimethyl-5-oxo-15-prop-1-en-2-yl-12,14,18-trioxapentacyclo[11.4.1.01,10.02,6.011,15]octadeca-3,8-dien-8-yl]methyl 2-(3-chloro-4-hydroxy-5-methoxyphenyl)acetate
Show/Hide
|
C37H39ClO9
|
2
|
| 1 |
EC50 = 5.7 nM
|
|
|
| 2 |
Ki = 1.03 nM
|
|
|
|
CP0424002
|
[(1R,2R,6R,10S,11R,15S,17R)-13-benzyl-6-hydroxy-4,17-dimethyl-5-oxo-15-prop-1-en-2-yl-12,14,18-trioxapentacyclo[11.4.1.01,10.02,6.011,15]octadeca-3,8-dien-8-yl]methyl 2-(2,3-difluorophenyl)acetate
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|
C36H36F2O7
|
1
|
| 1 |
EC50 = 9.1 nM
|
|
|
|
CP0424004
|
[(1R,2R,6R,10S,11R,15S,17R)-13-benzyl-6-hydroxy-4,17-dimethyl-5-oxo-15-prop-1-en-2-yl-12,14,18-trioxapentacyclo[11.4.1.01,10.02,6.011,15]octadeca-3,8-dien-8-yl]methyl 2-(2,6-difluorophenyl)acetate
Show/Hide
|
C36H36F2O7
|
1
|
| 1 |
EC50 = 11.3 nM
|
|
|
|
CP0372034
|
2-(3-(4-hydroxy-3-methoxybenzyl)thioureido)-4-(3,4-dimethylphenyl)butyl pivalate
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|
C26H36N2O4S
|
2
|
| 1 |
EC50 = 14.7 nM
|
|
|
| 2 |
Ki = 56 nM
|
|
|
|
CP0410340
|
N-[3-(3,4-dimethylphenyl)propyl]-2-(4-hydroxy-3-methoxyphenyl)propanamide
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|
C21H27NO3
|
2
|
| 1 |
EC50 = 21.3 nM
|
|
|
| 2 |
Ki = 177 nM
|
|
|
|
CP0372038
|
2-(3-(4-hydroxy-3-methoxybenzyl)thioureido)-4-(4-tert-butylphenyl)butyl pivalate
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|
C28H40N2O4S
|
2
|
| 1 |
EC50 = 21.5 nM
|
|
|
| 2 |
Ki = 36.5 nM
|
|
|
|
CP0118920
|
2,2-Dimethyl-propionic acid 2-(3,4-dimethyl-benzyl)-3-[3-(4-methanesulfonylamino-3-methoxy-benzyl)-thioureido]-propyl ester
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|
C27H39N3O5S2
|
2
|
| 1 |
EC50 = 22 nM
|
|
|
| 2 |
Ki = 49 nM
|
|
|
|
CP0425798
|
2-(4-tert-Butylbenzyl)-3-[2-(4-amino-3-methoxyphenyl)acetamido]propyl pivalate
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|
C28H40N2O4
|
2
|
| 1 |
EC50 = 22.9 nM
|
|
|
| 2 |
Ki = 108 nM
|
|
|
|
CP0445375
|
N-[(4-tert-butylphenyl)methyl]-2-(4-hydroxy-3-methoxyphenyl)propanamide
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|
C21H27NO3
|
2
|
| 1 |
EC50 = 24 nM
|
|
|
| 2 |
Ki = 308 nM
|
|
|
|
CP0445376
|
2-(4-hydroxy-3-methoxyphenyl)-N-nonylpropanamide
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|
C19H31NO3
|
2
|
| 1 |
EC50 = 26.3 nM
|
|
|
| 2 |
Ki = 159 nM
|
|
|
|
CP0426681
|
3-[(4-tert-butylphenyl)methyl]-1-[(4-methanesulfonamido-3-methoxyphenyl)methyl]thiourea
Show/Hide
|
C21H29N3O3S2
|
5
|
| 1 |
EC50 = 32.4 nM
|
|
|
| 2 |
Ki = 3.4 nM
|
|
|
| 3 |
Ki = 50 nM
|
|
|
| 4 |
Ki = 50.4 nM
|
|
|
| 5 |
Ki = 51 nM
|
|
|
|
CP0245890
|
2,2-Dimethyl-propionic acid 2-(4-tert-butyl-benzyl)-3-[3-(4-methanesulfonylamino-3-methoxy-benzyl)-thioureido]-propyl ester
Show/Hide
|
C29H43N3O5S2
|
1
|
| 1 |
EC50 = 40 nM
|
|
|
|
CP0492357
|
N-[3-(3,4-dimethylphenyl)propyl]-2-(4-hydroxy-3-methoxyphenyl)acetamide
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|
C20H25NO3
|
2
|
| 1 |
EC50 = 41 nM
|
|
|
| 2 |
Ki = 354 nM
|
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|
CP0049976
|
(6E)-N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methylnon-6-enamide
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|
C18H27NO3
|
2
|
| 1 |
EC50 = 44.8 nM
|
|
|
| 2 |
Ki = 1700 nM
|
|
|
|
CP0424005
|
[(1R,2R,6R,10S,11R,15S,17R)-13-benzyl-6-hydroxy-4,17-dimethyl-5-oxo-15-prop-1-en-2-yl-12,14,18-trioxapentacyclo[11.4.1.01,10.02,6.011,15]octadeca-3,8-dien-8-yl]methyl 2-(3,5-difluorophenyl)acetate
Show/Hide
|
C36H36F2O7
|
1
|
| 1 |
EC50 = 59 nM
|
|
|
|
CP0372286
|
2-(3-(3-chloro-4-hydroxy-5-methoxybenzyl)thioureido)-3-(4-tert-butylphenyl)propyl pivalate
Show/Hide
|
C27H37ClN2O4S
|
2
|
| 1 |
EC50 = 60 nM
|
|
|
| 2 |
Ki = 28.8 nM
|
|
|
|
CP0410339
|
2-(4-hydroxy-3-methoxyphenyl)-N-nonylacetamide
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|
C18H29NO3
|
2
|
| 1 |
EC50 = 61 nM
|
|
|
| 2 |
Ki = 240 nM
|
|
|
|
CP0410338
|
2-(4-Hydroxy-3-methoxy-phenyl)-N-octyl-acetamide
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|
C17H27NO3
|
2
|
| 1 |
EC50 = 77 nM
|
|
|
| 2 |
Ki = 848 nM
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|
|
CP0492356
|
N-[(4-tert-butylphenyl)methyl]-2-(4-hydroxy-3-methoxyphenyl)acetamide
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|
C20H25NO3
|
2
|
| 1 |
EC50 = 82 nM
|
|
|
| 2 |
Ki = 667 nM
|
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|
|
CP0416230
|
N-[(4-hydroxy-3-methoxyphenyl)methyl]decanamide
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|
C18H29NO3
|
2
|
| 1 |
EC50 = 83 nM
|
|
|
| 2 |
Ki = 864 nM
|
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CP0416228
|
2-(4-hydroxy-3-methoxyphenyl)-N-octylpropanamide
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|
C18H29NO3
|
2
|
| 1 |
EC50 = 130 nM
|
|
|
| 2 |
Ki = 744 nM
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|
CP0483185
|
1-[4-(2-Amino-ethoxy)-3-methoxy-benzyl]-3-(4-tert-butyl-benzyl)-thiourea
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|
C22H31N3O2S
|
2
|
| 1 |
EC50 = 132 nM
|
|
|
| 2 |
Ki = 84 nM
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CP0479125
|
N-[(4-tert-butylphenyl)methyl]-2-(2-chloro-4-hydroxy-5-methoxyphenyl)acetamide
Show/Hide
|
C20H24ClNO3
|
2
|
| 1 |
EC50 = 135 nM
|
|
|
| 2 |
Ki = 486 nM
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CP0340076
|
Benzoic acid 2-(3,4-dimethyl-benzyl)-3-[3-(4-methanesulfonylamino-3-methoxy-benzyl)-thioureido]-propyl ester
Show/Hide
|
C29H35N3O5S2
|
1
|
| 1 |
EC50 = 166 nM
|
|
|
|
CP0262336
|
(9Z)-N-[(4-hydroxy-3-methoxyphenyl)methyl]octadec-9-enamide
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|
C26H43NO3
|
2
|
| 1 |
EC50 = 202 nM
|
|
|
| 2 |
Ki = 142 nM
|
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|
CP0439703
|
N-[(4-tert-butylphenyl)methyl]-2-(3-chloro-4-hydroxyphenyl)acetamide
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|
C19H22ClNO2
|
2
|
| 1 |
EC50 = 206 nM
|
|
|
| 2 |
Ki = 132 nM
|
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CP0416231
|
N-[(4-tert-butylphenyl)methyl]-2-(3-fluoro-4-hydroxyphenyl)propanamide
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|
C20H24FNO2
|
2
|
| 1 |
EC50 = 221 nM
|
|
|
| 2 |
Ki = 178 nM
|
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|
CP0076630
|
N-[(4-hydroxy-3-methoxyphenyl)methyl]nonanamide
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|
C17H27NO3
|
2
|
| 1 |
EC50 = 223 nM
|
|
|
| 2 |
Ki = 1223 nM
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CP0416226
|
2-[4-(2-aminoethoxy)-3-methoxyphenyl]-N-[(4-tert-butylphenyl)methyl]propanamide
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|
C23H32N2O3
|
2
|
| 1 |
EC50 = 238 nM
|
|
|
| 2 |
Ki = 504 nM
|
|
|
|
CP0460399
|
2,2-Dimethyl-propionic acid 2-(3,4-dimethyl-benzyl)-3-[2-(4-methanesulfonylamino-3-methoxy-phenyl)-acetylamino]-propyl ester
Show/Hide
|
C27H38N2O6S
|
2
|
| 1 |
EC50 = 244 nM
|
|
|
| 2 |
Ki = 430 nM
|
|
|
|
CP0487136
|
1-[(4-tert-butylphenyl)methyl]-3-[[4-(ethenylsulfonylamino)phenyl]methyl]thiourea
Show/Hide
|
C21H27N3O2S2
|
2
|
| 1 |
EC50 = 250 nM
|
|
|
| 2 |
Ki = 231 nM
|
|
|
|
CP0402446
|
Benzoic acid 2-(4-tert-butyl-benzyl)-3-[3-(4-methanesulfonylamino-3-methoxy-benzyl)-thioureido]-propyl ester
Show/Hide
|
C31H39N3O5S2
|
1
|
| 1 |
EC50 = 252 nM
|
|
|
|
CP0416232
|
2-[4-(2-aminoethoxy)-3-methoxyphenyl]-N-[(4-tert-butylphenyl)methyl]acetamide
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|
C22H30N2O3
|
2
|
| 1 |
EC50 = 358 nM
|
|
|
| 2 |
Ki = 1230 nM
|
|
|
|
CP0409708
|
2,2-Dimethyl-propionic acid 2-(3,4-dimethyl-benzyl)-3-(4-methanesulfonylamino-3-methoxy-benzyloxythiocarbonylamino)-propyl ester
Show/Hide
|
C27H38N2O6S2
|
2
|
| 1 |
EC50 = 373 nM
|
|
|
| 2 |
Ki = 199 nM
|
|
|
|
CP0424000
|
N-[[(1R,2R,6R,10S,11R,15S,17R)-13-benzyl-6-hydroxy-4,17-dimethyl-5-oxo-15-prop-1-en-2-yl-12,14,18-trioxapentacyclo[11.4.1.01,10.02,6.011,15]octadeca-3,8-dien-8-yl]methyl]-2-[4-(methanesulfonamido)phenyl]acetamide
Show/Hide
|
C37H42N2O8S
|
1
|
| 1 |
EC50 = 375 nM
|
|
|
|
CP0399925
|
1-[(4-tert-butylphenyl)methyl]-3-[1-(4-hydroxy-3-methoxyphenyl)ethyl]thiourea
Show/Hide
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C21H28N2O2S
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2
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| 1 |
EC50 = 380 nM
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| 2 |
Ki = 194 nM
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CP0416229
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2-[4-(2-aminoethoxy)-3-methoxyphenyl]-N-[3-(3,4-dimethylphenyl)propyl]propanamide
Show/Hide
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C23H32N2O3
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2
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| 1 |
EC50 = 404 nM
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| 2 |
Ki = 518 nM
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CP0221907
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2,2-Dimethyl-propionic acid 3-[3-(4-acetylamino-benzyl)-thioureido]-2-(3,4-dimethyl-benzyl)-propyl ester
Show/Hide
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C27H37N3O3S
|
1
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| 1 |
EC50 = 450 nM
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CP0333259
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2-[4-(2-Amino-ethoxy)-3-methoxy-phenyl]-N-[3-(3,4-dimethyl-phenyl)-propyl]-acetamide
Show/Hide
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C22H30N2O3
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2
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| 1 |
EC50 = 589 nM
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| 2 |
Ki = 930 nM
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CP0399923
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(E)-N-[1-(4-hydroxy-3-methoxyphenyl)ethyl]octadec-9-enamide
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C27H45NO3
|
2
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| 1 |
EC50 = 678 nM
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| 2 |
Ki = 226 nM
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CP0065232
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2,2-Dimethyl-propionic acid 2-(3,4-dimethyl-benzyl)-3-{3-[4-(propane-2-sulfonylamino)-benzyl]-thioureido}-propyl ester
Show/Hide
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C28H41N3O4S2
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1
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| 1 |
EC50 = 790 nM
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CP0488881
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2,2-Dimethyl-propionic acid 2-(3,4-dimethyl-benzyl)-3-[3-(3-methoxy-4-methanesulfonylamino-benzyl)-thioureido-N-hydroxy]-propyl ester
Show/Hide
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C27H39N3O6S2
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2
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| 1 |
EC50 = 809 nM
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| 2 |
Ki = 396 nM
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CP0415716
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N-[(4-tert-butylphenyl)methyl]-2-(3-fluoro-4-hydroxyphenyl)acetamide
Show/Hide
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C19H22FNO2
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2
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| 1 |
EC50 = 911 nM
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| 2 |
Ki = 808 nM
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CP0222332
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2,2-Dimethyl-propionic acid 2-(3,4-dimethyl-benzyl)-3-[3-(3-methanesulfonylamino-benzyl)-thioureido]-propyl ester
Show/Hide
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C26H37N3O4S2
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1
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| 1 |
EC50 = 990 nM
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CP0448729
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1-(4-tert-Butyl-benzyl)-3-(3-methanesulfonyl-benzyl)-thiourea
Show/Hide
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C20H26N2O2S2
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2
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| 1 |
EC50 = 1010 nM
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| 2 |
Ki = 1000 nM
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CP0391975
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3-[(4-tert-butylphenyl)methyl]-1-hydroxy-1-[[4-(methanesulfonamido)phenyl]methyl]urea
Show/Hide
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C20H27N3O4S
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2
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| 1 |
EC50 = 1055 nM
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| 2 |
Ki = 3500 nM
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CP0373234
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[(2R,6R,10S,15S,17R)-13-benzyl-6-hydroxy-4,17-dimethyl-5-oxo-15-prop-1-en-2-yl-12,14,18-trioxapentacyclo[11.4.1.01,10.02,6.011,15]octadeca-3,8-dien-8-yl]methyl 2-(3,5-dibromophenyl)acetate
Show/Hide
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C36H36Br2O7
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2
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| 1 |
EC50 = 1070 nM
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| 2 |
Ki = 110 nM
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CP0079191
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2,2-Dimethyl-propionic acid 2-(3,4-dimethyl-benzyl)-3-[3-(4-isobutyrylamino-benzyl)-thioureido]-propyl ester
Show/Hide
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C29H41N3O3S
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1
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| 1 |
EC50 = 1140 nM
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CP0416233
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N-[1-(4-hydroxy-3-methoxyphenyl)ethyl]decanamide
Show/Hide
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C19H31NO3
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2
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| 1 |
EC50 = 1250 nM
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| 2 |
Ki = 3300 nM
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CP0399924
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N-[1-(4-hydroxy-3-methoxyphenyl)ethyl]nonanamide
Show/Hide
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C18H29NO3
|
2
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| 1 |
EC50 = 1580 nM
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| 2 |
Ki = 4275 nM
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CP0038427
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2,2-Dimethyl-propionic acid 2-(3,4-dimethyl-benzyl)-3-{3-[4-(methanesulfonylamino-methyl)-benzyl]-thioureido}-propyl ester
Show/Hide
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C27H39N3O4S2
|
1
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| 1 |
EC50 = 1700 nM
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CP0466519
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1-[(4-tert-butylphenyl)methyl]-3-[[4-(methanesulfonamidomethyl)phenyl]methyl]thiourea
Show/Hide
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C21H29N3O2S2
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2
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| 1 |
EC50 = 1720 nM
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| 2 |
Ki = 6120 nM
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CP0366899
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Benzoic acid 2-(3,4-dimethyl-benzyl)-3-[3-(4-methanesulfonylamino-benzyl)-thioureido]-propyl ester
Show/Hide
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C28H33N3O4S2
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1
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| 1 |
EC50 = 1730 nM
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CP0399830
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1-(4-tert-Butyl-benzyl)-3-(3-methanesulfinyl-benzyl)-thiourea
Show/Hide
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C20H26N2OS2
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2
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| 1 |
EC50 = 1890 nM
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| 2 |
Ki = 3600 nM
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CP0378152
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2-(4-tert-Butyl-phenyl)-N-hydroxy-N-(4-methanesulfonylamino-benzyl)-acetamide
Show/Hide
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C20H26N2O4S
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2
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| 1 |
EC50 = 1960 nM
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| 2 |
Ki = 5300 nM
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CP0435305
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1-[(4-tert-butylphenyl)methyl]-1-hydroxy-3-[[4-(methanesulfonamido)-3-methoxyphenyl]methyl]thiourea
Show/Hide
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C21H29N3O4S2
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2
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| 1 |
EC50 = 2000 nM
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| 2 |
Ki = 926 nM
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CP0154431
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Benzoic acid 2-(4-tert-butyl-benzyl)-3-[3-(4-methanesulfonylamino-benzyl)-thioureido]-propyl ester
Show/Hide
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C30H37N3O4S2
|
1
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| 1 |
EC50 = 2790 nM
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CP0480671
|
1-[(4-tert-butylphenyl)methyl]-3-[[3-(methanesulfonamido)phenyl]methyl]thiourea
Show/Hide
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C20H27N3O2S2
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2
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| 1 |
EC50 = 4100 nM
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| 2 |
Ki = 6000 nM
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CP0415717
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1-[1-[4-(2-aminoethoxy)-3-methoxyphenyl]ethyl]-3-[(4-tert-butylphenyl)methyl]thiourea
Show/Hide
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C23H33N3O2S
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2
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| 1 |
EC50 = 5800 nM
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| 2 |
Ki = 1430 nM
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CP0445645
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1-[(4-tert-butylphenyl)methyl]-3-[[3-fluoro-4-(methanesulfonamido)phenyl]methyl]-1-hydroxythiourea
Show/Hide
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C20H26FN3O3S2
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2
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| 1 |
EC50 > 7060 nM
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| 2 |
Ki = 800 nM
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CP0490196
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(2S)-N-(2-(6-(2-acetamidobenzo[d]thiazol-4-yloxy)pyrimidin-4-yl)-5-(trifluoromethyl)phenyl)-1-isobutyl-5-methylpyrrolidine-2-carboxamide
Show/Hide
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C30H31F3N6O3S
|
1
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| 1 |
IC50 = 0.069 nM
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CP0386522
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(R)-methyl 5-Chloro-6-(3-methyl-4-(6-(trifluoromethyl)-4-(3,4,5-trifluorophenyl)-1H-benzo[d]imidazol-2-yl)piperazin-1-yl)nicotinate
Show/Hide
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C26H20ClF6N5O2
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1
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| 1 |
IC50 = 0.3 nM
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CP0394313
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(R)-3-Amino-5-(2-(1-methoxypropan-2-ylamino)-6-(4-(trifluoromethyl)phenyl)pyrimidin-4-yloxy)quinoxalin-2(1H)-one
Show/Hide
|
C23H21F3N6O3
|
1
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| 1 |
IC50 = 0.3 nM
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CP0398937
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(S)-N-(2-(6-(2-acetamidobenzo[d]thiazol-4-yloxy)pyrimidin-4-yl)-5-(trifluoromethyl)phenyl)-1-isobutylpyrrolidine-2-carboxamide
Show/Hide
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C29H29F3N6O3S
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1
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| 1 |
IC50 = 0.36 nM
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CP0528798
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N-[4-[2-[1-(2-methylpropyl)-3,6-dihydro-2H-pyridin-4-yl]-6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl]oxy-1,3-benzothiazol-2-yl]acetamide
Show/Hide
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C29H28F3N5O2S
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2
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| 1 |
IC50 = 0.4 nM
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| 2 |
IC50 = 3.2 nM
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CP0122651
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4-(3-Chloro-pyridin-2-yl)-piperazine-1-carboxylic acid (4-tert-butyl-phenyl)-amide
Show/Hide
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C20H25ClN4O
|
2
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| 1 |
IC50 = 0.4 nM
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| 2 |
IC50 = 0.5 nM
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CP0403070
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N-[4-[6-[2-(1-pyridin-2-ylethylamino)-4-(trifluoromethyl)phenyl]pyrimidin-4-yl]oxy-1,3-benzothiazol-2-yl]acetamide
Show/Hide
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C27H21F3N6O2S
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1
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| 1 |
IC50 = 0.48 nM
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CP0384542
|
AMG 517
Show/Hide
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C20H13F3N4O2S
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2
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| 1 |
IC50 = 0.5 nM
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| 2 |
IC50 = 0.9 nM
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CP0384477
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(R)-N-(2-(6-(2-acetamidobenzo[d]thiazol-4-yloxy)pyrimidin-4-yl)-5-(trifluoromethyl)phenyl)-1-isobutylpyrrolidine-2-carboxamide
Show/Hide
|
C29H29F3N6O3S
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1
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| 1 |
IC50 = 0.53 nM
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CP0422042
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3-amino-5-({6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl}oxy)-1,2-dihydroquinoxalin-2-one
Show/Hide
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C19H12F3N5O2
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2
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| 1 |
IC50 = 0.57 nM
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| 2 |
IC50 = 0.64 nM
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CP0455050
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tert-butyl 4-[4-[(2-acetamido-1,3-benzothiazol-4-yl)oxy]-6-[4-(trifluoromethyl)phenyl]pyrimidin-2-yl]-3,6-dihydro-2H-pyridine-1-carboxylate
Show/Hide
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C30H28F3N5O4S
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2
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| 1 |
IC50 = 0.6 nM
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| 2 |
IC50 = 1.8 nM
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CP0518210
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(R)-1-(5-chloro-6-((R)-3-methyl-4-(6-(trifluoromethyl)-4-(3,4,5-trifluorophenyl)-1H-benzo[d]imidazol-2-yl)piperazin-1-yl)pyridin-3-yl)ethanol
Show/Hide
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C26H22ClF6N5O
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2
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| 1 |
IC50 = 0.6 nM
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| 2 |
IC50 = 2.3 nM
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CP0384648
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3-Amino-5-(2-(2-methoxyethylamino)-6-(4-(trifluoromethyl)-phenyl)pyrimidin-4-yloxy)quinoxalin-2(1H)-one
Show/Hide
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C22H19F3N6O3
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2
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| 1 |
IC50 = 0.6 nM
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| 2 |
IC50 = 0.8 nM
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CP0427673
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(S)-N-(2-(6-(2-acetamidobenzo[d]thiazol-4-yloxy)pyrimidin-4-yl)-5-(trifluoromethyl)phenyl)-1-isobutyl-2-methylpyrrolidine-2-carboxamide
Show/Hide
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C30H31F3N6O3S
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1
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| 1 |
IC50 = 0.68 nM
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CP0525925
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(R)-(6-(3-methyl-4-(6-(trifluoromethyl)-4-(3,4,5-trifluorophenyl)-1H-benzo[d]imidazol-2-yl)piperazin-1-yl)-5-(trifluoromethyl)pyridin-3-yl)methanol (
Show/Hide
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C26H20F9N5O
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2
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| 1 |
IC50 = 0.7 nM
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| 2 |
IC50 = 1.4 nM
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CP0422039
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3-Amino-5-(6-(2-(2-methoxyethylamino)-6-(trifluoromethyl)-pyridin-3-yl)pyrimidin-4-yloxy)quinoxalin-2(1H)-one
Show/Hide
|
C21H18F3N7O3
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2
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| 1 |
IC50 = 0.7 nM
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| 2 |
IC50 = 1.3 nM
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CP0445206
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N-[2-[6-[(3-amino-2-oxo-1H-quinoxalin-5-yl)oxy]pyrimidin-4-yl]-5-(trifluoromethyl)phenyl]pyridine-2-carboxamide
Show/Hide
|
C25H16F3N7O3
|
1
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| 1 |
IC50 = 0.7 nM
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CP0394316
|
3-Amino-5-(6-(2-amino-6-(trifluoromethyl)pyridin-3-yl)pyrimidin-4-yloxy)quinoxalin-2(1H)-one
Show/Hide
|
C18H12F3N7O2
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2
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| 1 |
IC50 = 0.8 nM
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| 2 |
IC50 = 2.7 nM
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CP0433671
|
(S)-3-Amino-5-(2-(1-methoxypropan-2-ylamino)-6-(4-(trifluoromethyl)phenyl)pyrimidin-4-yloxy)quinoxalin-2(1H)-one
Show/Hide
|
C23H21F3N6O3
|
2
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| 1 |
IC50 = 0.8 nM
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| 2 |
IC50 = 1 nM
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CP0394315
|
3-Amino-5-(6-(2-((R)-tetrahydrofuran-3-ylamino)-6-(trifluoromethyl)pyridin-3-yl)pyrimidin-4-yloxy)quinoxalin-2(1H)-one
Show/Hide
|
C22H18F3N7O3
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2
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| 1 |
IC50 = 0.8 nM
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| 2 |
IC50 = 1.1 nM
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CP0386524
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(R,S)-1-(5-chloro-6-((R)-3-methyl-4-(6-(trifluoromethyl)-4-(3,4,5-trifluorophenyl)-1H-benzo[d]imidazol-2-yl)piperazin-1-yl)pyridin-3-yl)ethane-1,2-diol
Show/Hide
|
C26H22ClF6N5O2
|
1
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| 1 |
IC50 = 0.9 nM
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CP0537910
|
(R)-(5-chloro-6-(4-(4-(dibenzylamino)-6-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)-3-methylpiperazin-1-yl)pyridin-3-yl)-methanol
Show/Hide
|
C33H32ClF3N6O
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2
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| 1 |
IC50 = 0.9 nM
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| 2 |
IC50 = 1.9 nM
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CP0422044
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3-Amino-5-(6-(2-((1-isobutylpiperidin-2-yl)methylamino)-6-(trifluoromethyl)pyridin-3-yl)pyrimidin-4-yloxy)quinoxalin-2(1H)-one
Show/Hide
|
C28H31F3N8O2
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2
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| 1 |
IC50 = 0.9 nM
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| 2 |
IC50 = 1.7 nM
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CP0458594
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(R)-(5-chloro-6-(3-methyl-4-(5-(4-(trifluoromethyl)phenyl)-4-(3,4,5-trifluorophenyl)-1H-imidazol-2-yl)piperazin-1-yl)pyridin-3-yl)methanol
Show/Hide
|
C27H22ClF6N5O
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2
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| 1 |
IC50 = 1 nM
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| 2 |
IC50 = 4 nM
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CP0554123
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N-[2-[6-[(2-acetamido-1,3-benzothiazol-4-yl)oxy]pyrimidin-4-yl]-5-(trifluoromethyl)phenyl]pyridine-2-carboxamide
Show/Hide
|
C26H17F3N6O3S
|
1
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| 1 |
IC50 = 1 nM
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CP0541664
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(R,S)-1-(6-((R)-3-methyl-4-(6-(trifluoromethyl)-4-(3,4,5-trifluorophenyl)-1H-benzo[d]imidazol-2-yl)piperazin-1-yl)-5-(trifluoromethyl)pyridin-3-yl)ethanol
Show/Hide
|
C27H22F9N5O
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2
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| 1 |
IC50 = 1 nM
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| 2 |
IC50 = 1.5 nM
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CP0433239
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N-[4-[2-pyridin-4-yl-6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl]oxy-1,3-benzothiazol-2-yl]acetamide
Show/Hide
|
C25H16F3N5O2S
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2
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| 1 |
IC50 = 1.1 nM
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| 2 |
IC50 = 6.2 nM
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CP0454341
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N-[4-[2-morpholin-4-yl-6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl]oxy-1,3-benzothiazol-2-yl]acetamide
Show/Hide
|
C24H20F3N5O3S
|
2
|
| 1 |
IC50 = 1.1 nM
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| 2 |
IC50 = 28 nM
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CP0541666
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(R)-tert-butyl 2-(4-(3-Chloro-5-(hydroxymethyl)pyridin-2-yl)-2-methylpiperazin-1-yl)-6-(trifluoromethyl)-1H-benzo[d]imidazol-4-ylcarbamate
Show/Hide
|
C24H28ClF3N6O3
|
2
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| 1 |
IC50 = 1.1 nM
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| 2 |
IC50 = 2.1 nM
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CP0398935
|
N-[2-[6-[(2-acetamido-1,3-benzothiazol-4-yl)oxy]pyrimidin-4-yl]-5-(trifluoromethyl)phenyl]-5,5-dimethylpyrrolidine-2-carboxamide
Show/Hide
|
C27H25F3N6O3S
|
1
|
| 1 |
IC50 = 1.2 nM
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CP0500423
|
4-({6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl}oxy)-1,3-benzothiazol-2-amine
Show/Hide
|
C18H11F3N4OS
|
2
|
| 1 |
IC50 = 1.2 nM
|
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| 2 |
IC50 > 4000 nM
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CP0451804
|
(R)-N-(2-(4-(3-chloro-5-(hydroxymethyl)pyridin-2-yl)-2-methylpiperazin-1-yl)-6-(trifluoromethyl)-1H-benzo[d]imidazol-4-yl)cyclohexanecarboxamide
Show/Hide
|
C26H30ClF3N6O2
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2
|
| 1 |
IC50 = 1.2 nM
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| 2 |
IC50 = 1.6 nM
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CP0527728
|
(R)-2-(4-(3-chloro-5-vinylpyridin-2-yl)-2-methylpiperazin-1-yl)-6-(trifluoromethyl)-4-(3,4,5-trifluorophenyl)-1H-benzo[d]-imidazole
Show/Hide
|
C26H20ClF6N5
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2
|
| 1 |
IC50 = 1.3 nM
|
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| 2 |
IC50 = 1.7 nM
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CP0454339
|
N-[4-[2-methyl-6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl]oxy-1,3-benzothiazol-2-yl]acetamide
Show/Hide
|
C21H15F3N4O2S
|
2
|
| 1 |
IC50 = 1.4 nM
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|
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| 2 |
IC50 = 9.3 nM
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CP0510606
|
N-[4-[2-piperidin-1-yl-6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl]oxy-1,3-benzothiazol-2-yl]acetamide
Show/Hide
|
C25H22F3N5O2S
|
2
|
| 1 |
IC50 = 1.5 nM
|
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| 2 |
IC50 = 5.1 nM
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CP0529691
|
N-[4-[2-(1-pyridin-2-ylethylamino)-6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl]oxy-1,3-benzothiazol-2-yl]acetamide
Show/Hide
|
C27H21F3N6O2S
|
2
|
| 1 |
IC50 = 1.5 nM
|
|
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| 2 |
IC50 = 1.6 nM
|
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|
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CP0384647
|
3-Amino-5-(6-(2-amino-4-(trifluoromethyl)phenyl)pyrimidin-4-yloxy)quinoxalin-2(1H)-one
Show/Hide
|
C19H13F3N6O2
|
2
|
| 1 |
IC50 = 1.5 nM
|
|
|
| 2 |
IC50 = 3.9 nM
|
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|
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CP0498643
|
ethyl 3-[(7-hydroxynaphthalen-1-yl)carbamoylamino]benzoate
Show/Hide
|
C20H18N2O4
|
1
|
| 1 |
IC50 = 1.6 nM
|
|
|
|
CP0435893
|
N-{4-[(6-{4-[(1S)-1-[4-(trifluoromethyl)phenyl]ethyl]piperazin-1-yl}pyrimidin-4-yl)oxy]-1,3-benzothiazol-2-yl}acetamide
Show/Hide
|
C26H25F3N6O2S
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2
|
| 1 |
IC50 = 1.8 nM
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| 2 |
IC50 = 5 nM
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CP0386527
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(R)-2-(4-(3-bromopyridin-2-yl)-3-methylpiperazin-1-yl)-6-(trifluoromethyl)-4-(3,4,5-trifluorophenyl)-1H-benzo[d]imidazole
Show/Hide
|
C24H18BrF6N5
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2
|
| 1 |
IC50 = 1.8 nM
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| 2 |
IC50 = 4.3 nM
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CP0504351
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1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(7-hydroxynaphthalen-1-yl)urea
Show/Hide
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C18H12ClF3N2O2
|
1
|
| 1 |
IC50 = 1.9 nM
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CP0503994
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N-[6-(4-tert-butylphenyl)pyrimidin-4-yl]quinolin-7-amine
Show/Hide
|
C23H22N4
|
2
|
| 1 |
IC50 = 2 nM
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| 2 |
IC50 = 22 nM
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CP0437375
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N-{4-[(6-{4-[(1R)-1-(4-fluorophenyl)ethyl]piperazin-1-yl}pyrimidin-4-yl)oxy]-1,3-benzothiazol-2-yl}acetamide
Show/Hide
|
C25H25FN6O2S
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2
|
| 1 |
IC50 = 2 nM
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| 2 |
IC50 = 3.7 nM
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CP0422040
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3-amino-5-(2-((1-neopentylpiperidin-2-yl)methylamino)-6-(4-(trifluoromethyl)phenyl)pyrimidin-4-yloxy)quinoxalin-2(1H)-one
Show/Hide
|
C30H34F3N7O2
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2
|
| 1 |
IC50 = 2 nM
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| 2 |
IC50 = 2.1 nM
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CP0394312
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N-[2-[6-[(3-amino-2-oxo-1H-quinoxalin-5-yl)oxy]pyrimidin-4-yl]-5-(trifluoromethyl)phenyl]pyridine-4-carboxamide
Show/Hide
|
C25H16F3N7O3
|
2
|
| 1 |
IC50 = 2.1 nM
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| 2 |
IC50 = 3.3 nM
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CP0483443
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1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(2,3-dichloro-7-hydroxynaphthalen-1-yl)urea
Show/Hide
|
C18H10Cl3F3N2O2
|
1
|
| 1 |
IC50 = 2.1 nM
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CP0449189
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3-Amino-5-(6-(2-(2-morpholinoethylamino)-6-(trifluoromethyl)pyridin-3-yl)pyrimidin-4-yloxy)quinoxalin-2(1H)-one
Show/Hide
|
C24H23F3N8O3
|
2
|
| 1 |
IC50 = 2.2 nM
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| 2 |
IC50 = 18.8 nM
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CP0427671
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(2S)-N-(2-(6-(2-acetamidobenzo[d]thiazol-4-yloxy)pyrimidin-4-yl)-5-(trifluoromethyl)phenyl)-5-methylpyrrolidine-2-carboxamide
Show/Hide
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C26H23F3N6O3S
|
1
|
| 1 |
IC50 = 2.4 nM
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CP0526715
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N-[4-({6-[4-(trifluoromethyl)cyclohex-1-en-1-yl]pyrimidin-4-yl}oxy)-1,3-benzothiazol-2-yl]acetamide
Show/Hide
|
C20H17F3N4O2S
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2
|
| 1 |
IC50 = 2.4 nM
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| 2 |
IC50 = 27 nM
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CP0394317
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1-(2-(6-(2-Acetamidobenzo[d]thiazol-4-yloxy)pyrimidin-4-yl)-5-(trifluoromethyl)phenyl)-3-tert-butylurea
Show/Hide
|
C25H23F3N6O3S
|
2
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| 1 |
IC50 = 2.4 nM
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| 2 |
IC50 = 6 nM
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CP0509885
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N-{4-[(6-{4-[(1S)-1-(2-fluorophenyl)ethyl]piperazin-1-yl}pyrimidin-4-yl)oxy]-1,3-benzothiazol-2-yl}acetamide
Show/Hide
|
C25H25FN6O2S
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2
|
| 1 |
IC50 = 2.5 nM
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| 2 |
IC50 = 2.7 nM
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CP0451802
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(S)-1-(5-chloro-6-((R)-3-methyl-4-(6-(trifluoromethyl)-4-(3,4,5-trifluorophenyl)-1H-benzo[d]imidazol-2-yl)piperazin-1-yl)pyridin-3-yl)ethanol
Show/Hide
|
C26H22ClF6N5O
|
2
|
| 1 |
IC50 = 2.6 nM
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| 2 |
IC50 = 3 nM
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CP0541668
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(R)-2-(4-(3-bromopyridin-2-yl)-2-methylpiperazin-1-yl)-6-(trifluoromethyl)-4-(3,4,5-trifluorophenyl)-1H-benzo[d]imidazole
Show/Hide
|
C24H18BrF6N5
|
2
|
| 1 |
IC50 = 2.6 nM
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| 2 |
IC50 = 6.7 nM
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CP0422045
|
4-(3-Amino-2-oxo-1,2-dihydroquinoxalin-5-yloxy)-6-(4-(trifluoromethyl)phenyl)pyrimidin-2-aminium trifluoroacetate
Show/Hide
|
C19H13F3N6O2
|
2
|
| 1 |
IC50 = 2.6 nM
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| 2 |
IC50 = 3.7 nM
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CP0433675
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3-Amino-5-(6-(2-amino-4-(trifluoromethyl)phenyl)-2-((S)-1-methoxypropan-2-ylamino)pyrimidin-4-yloxy)quinoxalin-2(1H)-one
Show/Hide
|
C23H22F3N7O3
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2
|
| 1 |
IC50 = 2.7 nM
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| 2 |
IC50 = 3.8 nM
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CP0455039
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N-[4-[2-(pyridin-2-ylmethylamino)-6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl]oxy-1,3-benzothiazol-2-yl]acetamide
Show/Hide
|
C26H19F3N6O2S
|
2
|
| 1 |
IC50 = 2.8 nM
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| 2 |
IC50 = 5.9 nM
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CP0403071
|
(S)-N-(2-(6-(2-acetamidobenzo[d]thiazol-4-yloxy)pyrimidin-4-yl)-5-(trifluoromethyl)phenyl)-2-methylpyrrolidine-2-carboxamide
Show/Hide
|
C26H23F3N6O3S
|
1
|
| 1 |
IC50 = 2.8 nM
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CP0543815
|
[6-[(3R)-3-methyl-4-[6-(trifluoromethyl)-4-(3,4,5-trifluorophenyl)-1H-benzimidazol-2-yl]piperazin-1-yl]-5-(trifluoromethyl)pyridin-3-yl]-phenylmethanol
Show/Hide
|
C32H24F9N5O
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2
|
| 1 |
IC50 = 2.8 nM
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| 2 |
IC50 = 3.7 nM
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CP0433677
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3-Amino-5-(2-(1-(pyridin-2-yl)ethylamino)-6-(4-(trifluoromethyl)-phenyl)pyrimidin-4-yloxy)quinoxalin-2(1H)-one
Show/Hide
|
C26H20F3N7O2
|
2
|
| 1 |
IC50 = 2.8 nM
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| 2 |
IC50 = 5.7 nM
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CP0500433
|
N-[4-({6-[4-(2,2-dimethylpropyl)piperazin-1-yl]pyrimidin-4-yl}oxy)-1,3-benzothiazol-2-yl]acetamide
Show/Hide
|
C22H28N6O2S
|
2
|
| 1 |
IC50 = 3 nM
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| 2 |
IC50 = 5 nM
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CP0435899
|
N-{4-[(6-{4-[1-(4-fluorophenyl)ethyl]piperazin-1-yl}pyrimidin-4-yl)oxy]-1,3-benzothiazol-2-yl}acetamide
Show/Hide
|
C25H25FN6O2S
|
2
|
| 1 |
IC50 = 3.1 nM
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| 2 |
IC50 = 4.9 nM
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CP0513959
|
1-(3-chlorophenyl)-3-(7-hydroxynaphthalen-1-yl)urea
Show/Hide
|
C17H13ClN2O2
|
1
|
| 1 |
IC50 = 3.2 nM
|
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CP0451801
|
(R)-2-(4-(5-bromo-3-chloropyridin-2-yl)-2-methylpiperazin-1-yl)-6-(trifluoromethyl)-4-(3,4,5-trifluorophenyl)-1H-benzo[d]-imidazole
Show/Hide
|
C24H17BrClF6N5
|
2
|
| 1 |
IC50 = 3.3 nM
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| 2 |
IC50 = 3.4 nM
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CP0489348
|
tert-butyl 4-[4-[(2-acetamido-1,3-benzothiazol-4-yl)oxy]-6-[4-(trifluoromethyl)phenyl]pyrimidin-2-yl]piperazine-1-carboxylate
Show/Hide
|
C29H29F3N6O4S
|
2
|
| 1 |
IC50 = 3.4 nM
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| 2 |
IC50 = 43 nM
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CP0485404
|
N-[4-[6-[2-amino-4-(trifluoromethyl)phenyl]pyrimidin-4-yl]oxy-1,3-benzothiazol-2-yl]acetamide
Show/Hide
|
C20H14F3N5O2S
|
2
|
| 1 |
IC50 = 3.6 nM
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| 2 |
IC50 = 15.9 nM
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CP0553061
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N-[4-[2-(pyridin-4-ylmethylamino)-6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl]oxy-1,3-benzothiazol-2-yl]acetamide
Show/Hide
|
C26H19F3N6O2S
|
2
|
| 1 |
IC50 = 3.9 nM
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| 2 |
IC50 = 6.1 nM
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CP0455049
|
N-[4-[2-[4-(2-methylpropyl)piperazin-1-yl]-6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl]oxy-1,3-benzothiazol-2-yl]acetamide
Show/Hide
|
C28H29F3N6O2S
|
2
|
| 1 |
IC50 = 4 nM
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| 2 |
IC50 = 12 nM
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CP0451805
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4-(4-tert-butylphenyl)-6-(trifluoromethyl)-2-(4-(3-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)-1H-benzo[d]imidazole
Show/Hide
|
C28H27F6N5
|
2
|
| 1 |
IC50 = 4 nM
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| 2 |
IC50 = 13 nM
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CP0511658
|
1-(2-(6-(3-Amino-2-oxo-1,2-dihydroquinoxalin-5-yloxy)pyrimidin-4-yl)-5-(trifluoromethyl)phenyl)-3-tert-butylurea
Show/Hide
|
C24H22F3N7O3
|
2
|
| 1 |
IC50 = 4.1 nM
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| 2 |
IC50 = 5.2 nM
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CP0433237
|
N-[4-[2-(pyridin-3-ylmethylamino)-6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl]oxy-1,3-benzothiazol-2-yl]acetamide
Show/Hide
|
C26H19F3N6O2S
|
2
|
| 1 |
IC50 = 4.2 nM
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| 2 |
IC50 = 7.8 nM
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CP0422341
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N-[2-[6-[(2-acetamido-1,3-benzothiazol-4-yl)oxy]pyrimidin-4-yl]-5-(trifluoromethyl)phenyl]-2-(dimethylamino)acetamide
Show/Hide
|
C24H21F3N6O3S
|
1
|
| 1 |
IC50 = 4.2 nM
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CP0433644
|
3-Amino-5-(6-(2-amino-4-(trifluoromethyl)phenyl)-2-(2-methoxyethylamino)pyrimidin-4-yloxy)quinoxalin-2(1H)-one
Show/Hide
|
C22H20F3N7O3
|
2
|
| 1 |
IC50 = 4.3 nM
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| 2 |
IC50 = 5.9 nM
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CP0433673
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3-amino-5-(6-(2-amino-6-(trifluoromethyl)pyridin-3-yl)-2-((S)-1-methoxypropan-2-ylamino)pyrimidin-4-yloxy)quinoxalin-2(1H)-one
Show/Hide
|
C22H21F3N8O3
|
2
|
| 1 |
IC50 = 4.4 nM
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| 2 |
IC50 = 6.4 nM
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CP0440809
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N-[4-[2-(dimethylamino)-6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl]oxy-1,3-benzothiazol-2-yl]acetamide
Show/Hide
|
C22H18F3N5O2S
|
2
|
| 1 |
IC50 = 4.5 nM
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| 2 |
IC50 = 11 nM
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CP0377431
|
N-{6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl}quinolin-7-amine
Show/Hide
|
C20H13F3N4
|
2
|
| 1 |
IC50 = 4.5 nM
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| 2 |
IC50 = 6.6 nM
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CP0441341
|
1-(7-hydroxynaphthalen-1-yl)-3-(3-(trifluoromethyl)phenyl)urea
Show/Hide
|
C18H13F3N2O2
|
1
|
| 1 |
IC50 = 4.5 nM
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CP0498937
|
1-(3,4-dichlorophenyl)-3-(7-hydroxynaphthalen-1-yl)urea
Show/Hide
|
C17H12Cl2N2O2
|
1
|
| 1 |
IC50 = 4.5 nM
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CP0511428
|
1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(2-chloro-7-hydroxynaphthalen-1-yl)urea
Show/Hide
|
C18H11Cl2F3N2O2
|
1
|
| 1 |
IC50 = 4.5 nM
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CP0394314
|
N-[4-[2-amino-6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl]oxy-1,3-benzothiazol-2-yl]acetamide
Show/Hide
|
C20H14F3N5O2S
|
3
|
| 1 |
IC50 = 4.8 nM
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|
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| 2 |
IC50 = 11.9 nM
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| 3 |
IC50 = 12 nM
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CP0422363
|
8-[[6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl]amino]naphthalen-2-ol
Show/Hide
|
C21H14F3N3O
|
1
|
| 1 |
IC50 = 4.8 nM
|
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CP0500432
|
N-{4-[(6-{4-[(1S)-1-phenylethyl]piperazin-1-yl}pyrimidin-4-yl)oxy]-1,3-benzothiazol-2-yl}acetamide
Show/Hide
|
C25H26N6O2S
|
2
|
| 1 |
IC50 = 4.8 nM
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| 2 |
IC50 = 6 nM
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CP0498939
|
1-(3-bromo-2-chloro-7-hydroxynaphthalen-1-yl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea
Show/Hide
|
C18H10BrCl2F3N2O2
|
1
|
| 1 |
IC50 = 4.9 nM
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CP0504375
|
1-(7-hydroxynaphthalen-1-yl)-3-(4-(trifluoromethyl)phenyl)urea
Show/Hide
|
C18H13F3N2O2
|
1
|
| 1 |
IC50 = 4.9 nM
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CP0500426
|
N-{4-[(6-{4-[(1S)-1-(4-fluorophenyl)ethyl]piperazin-1-yl}pyrimidin-4-yl)oxy]-1,3-benzothiazol-2-yl}acetamide
Show/Hide
|
C25H25FN6O2S
|
2
|
| 1 |
IC50 = 5 nM
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| 2 |
IC50 = 7 nM
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CP0412688
|
5-chloro-8-[[6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl]amino]-1,2,3,4-tetrahydronaphthalen-2-ol
Show/Hide
|
C21H17ClF3N3O
|
1
|
| 1 |
IC50 = 5.6 nM
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CP0461225
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N-[4-[2-[[1-(2-methylpropyl)piperidin-2-yl]methylamino]-6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl]oxy-1,3-benzothiazol-2-yl]acetamide
Show/Hide
|
C30H33F3N6O2S
|
2
|
| 1 |
IC50 = 6.1 nM
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| 2 |
IC50 = 11 nM
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CP0527729
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(R)-(6-(4-(4-(benzylamino)-6-(trifluoromethyl)-1H-benzo[d]-imidazol-2-yl)-3-methylpiperazin-1-yl)-5-chloropyridin-3-yl)-methanol
Show/Hide
|
C26H26ClF3N6O
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2
|
| 1 |
IC50 = 6.7 nM
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| 2 |
IC50 = 7 nM
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CP0490390
|
1-(5-(4-(trifluoromethyl)phenyl)-4-(3,4,5-trifluorophenyl)-1H-imidazol-2-yl)-4-(3-(trifluoromethyl)pyridin-2-yl)piperazine
Show/Hide
|
C26H18F9N5
|
2
|
| 1 |
IC50 = 7 nM
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| 2 |
IC50 = 20 nM
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CP0492871
|
N-{4-[(6-{4-[(1S)-1-(3-fluorophenyl)ethyl]piperazin-1-yl}pyrimidin-4-yl)oxy]-1,3-benzothiazol-2-yl}acetamide
Show/Hide
|
C25H25FN6O2S
|
2
|
| 1 |
IC50 = 7 nM
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| 2 |
IC50 = 16 nM
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CP0255650
|
3-(7-hydroxynaphthalen-1-yl)-1-[3-(methylsulfanyl)phenyl]urea
Show/Hide
|
C18H16N2O2S
|
2
|
| 1 |
IC50 = 7.1 nM
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| 2 |
IC50 = 35 nM
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CP0377430
|
7-({6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl}oxy)quinoline
Show/Hide
|
C20H12F3N3O
|
2
|
| 1 |
IC50 = 7.4 nM
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| 2 |
IC50 = 8 nM
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CP0492873
|
N-(4-{[6-(4-phenylpiperazin-1-yl)pyrimidin-4-yl]oxy}-1,3-benzothiazol-2-yl)acetamide
Show/Hide
|
C23H22N6O2S
|
2
|
| 1 |
IC50 = 7.5 nM
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| 2 |
IC50 = 43 nM
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CP0245749
|
2-[(3,4-dimethylphenyl)methyl]-3-({[(3-fluoro-4-methanesulfonamidophenyl)methyl]carbamothioyl}amino)propyl 2,2-dimethylpropanoate
Show/Hide
|
C26H36FN3O4S2
|
3
|
| 1 |
IC50 = 7.8 nM
|
|
|
| 2 |
Ki = 7.8 nM
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| 3 |
Ki = 54 nM
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CP0460670
|
1-(3-bromophenyl)-3-(7-hydroxynaphthalen-1-yl)urea
Show/Hide
|
C17H13BrN2O2
|
1
|
| 1 |
IC50 = 8 nM
|
|
|
|
CP0481279
|
(R)-N-(2-(6-(2-acetamidobenzo[d]thiazol-4-yloxy)pyrimidin-4-yl)-5-(trifluoromethyl)phenyl)pyrrolidine-2-carboxamide
Show/Hide
|
C25H21F3N6O3S
|
1
|
| 1 |
IC50 = 8.2 nM
|
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CP0524477
|
1-(7-hydroxynaphthalen-1-yl)-3-(3-methoxyphenyl)urea
Show/Hide
|
C18H16N2O3
|
1
|
| 1 |
IC50 = 8.6 nM
|
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CP0489307
|
N-[4-[2-(1-pyridin-3-ylethylamino)-6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl]oxy-1,3-benzothiazol-2-yl]acetamide
Show/Hide
|
C27H21F3N6O2S
|
2
|
| 1 |
IC50 = 8.7 nM
|
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| 2 |
IC50 = 9.3 nM
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CP0422041
|
3-amino-5-(2-(3-hydroxybutylamino)-6-(4-(trifluoromethyl)phenyl)pyrimidin-4-yloxy)quinoxalin-2(1H)-one
Show/Hide
|
C23H21F3N6O3
|
2
|
| 1 |
IC50 = 8.7 nM
|
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| 2 |
IC50 = 16.1 nM
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CP0503931
|
6-(trifluoromethyl)-4-(4-(trifluoromethyl)cyclohexyl)-2-(4-(3-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)-1H-benzo[d]-imidazole
Show/Hide
|
C25H24F9N5
|
2
|
| 1 |
IC50 = 9 nM
|
|
|
| 2 |
IC50 = 10 nM
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CP0386523
|
(R)-N-(5-chloro-6-(4-(4-(4-fluorophenyl)-6-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)-3-methylpiperazin-1-yl)pyridin-3-yl)-2-hydroxyacetamide
Show/Hide
|
C26H23ClF4N6O2
|
2
|
| 1 |
IC50 = 9.2 nM
|
|
|
| 2 |
IC50 = 30 nM
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CP0457176
|
5-bromo-8-[[6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl]amino]-1,2,3,4-tetrahydronaphthalen-2-ol
Show/Hide
|
C21H17BrF3N3O
|
1
|
| 1 |
IC50 = 9.6 nM
|
|
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|
CP0384543
|
N-[4-[6-[6-(trifluoromethyl)pyridin-3-yl]pyrimidin-4-yl]oxy-1,3-benzothiazol-2-yl]acetamide
Show/Hide
|
C19H12F3N5O2S
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0500431
|
N-[4-({6-[4-(trifluoromethyl)cyclohexyl]pyrimidin-4-yl}oxy)-1,3-benzothiazol-2-yl]acetamide
Show/Hide
|
C20H19F3N4O2S
|
2
|
| 1 |
IC50 = 10 nM
|
|
|
| 2 |
IC50 = 350 nM
|
|
|
|
CP0433209
|
7-chloro-8-[[6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl]amino]-1,2,3,4-tetrahydronaphthalen-2-ol
Show/Hide
|
C21H17ClF3N3O
|
1
|
| 1 |
IC50 = 11 nM
|
|
|
|
CP0492887
|
4-Oxopyrimidine, 20
Show/Hide
|
C20H13F3N4O
|
2
|
| 1 |
IC50 = 11 nM
|
|
|
| 2 |
IC50 = 62 nM
|
|
|
|
CP0486659
|
1-(4-chlorophenyl)-3-(7-hydroxynaphthalen-1-yl)urea
Show/Hide
|
C17H13ClN2O2
|
1
|
| 1 |
IC50 = 11 nM
|
|
|
|
CP0498644
|
1-(3,5-dichlorophenyl)-3-(7-hydroxynaphthalen-1-yl)urea
Show/Hide
|
C17H12Cl2N2O2
|
1
|
| 1 |
IC50 = 12 nM
|
|
|
|
CP0498938
|
1-(2-chloro-5-(trifluoromethyl)phenyl)-3-(7-hydroxynaphthalen-1-yl)urea
Show/Hide
|
C18H12ClF3N2O2
|
1
|
| 1 |
IC50 = 12 nM
|
|
|
|
CP0384544
|
(S)-N-(2-(6-(2-acetamidobenzo[d]thiazol-4-yloxy)pyrimidin-4-yl)-5-(trifluoromethyl)phenyl)pyrrolidine-2-carboxamide
Show/Hide
|
C25H21F3N6O3S
|
1
|
| 1 |
IC50 = 13 nM
|
|
|
|
CP0461753
|
4-Oxopyrimidine, 30
Show/Hide
|
C19H12F3N5O
|
2
|
| 1 |
IC50 = 14 nM
|
|
|
| 2 |
IC50 > 4000 nM
|
|
|
|
CP0476848
|
1-(7-hydroxynaphthalen-1-yl)-3-(3-nitrophenyl)urea
Show/Hide
|
C17H13N3O4
|
1
|
| 1 |
IC50 = 14 nM
|
|
|
|
CP0433238
|
N-[4-[2-[[1-(2-methylpropyl)piperidin-3-yl]methylamino]-6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl]oxy-1,3-benzothiazol-2-yl]acetamide
Show/Hide
|
C30H33F3N6O2S
|
2
|
| 1 |
IC50 = 15 nM
|
|
|
| 2 |
IC50 = 20 nM
|
|
|
|
CP0529370
|
4-Oxopyrimidine, 28a
Show/Hide
|
C20H12F3N3O
|
2
|
| 1 |
IC50 = 15 nM
|
|
|
| 2 |
IC50 > 4000 nM
|
|
|
|
CP0529371
|
4-Oxopyrimidine, 22
Show/Hide
|
C22H15F3N4O2
|
2
|
| 1 |
IC50 = 15 nM
|
|
|
| 2 |
IC50 = 77 nM
|
|
|
|
CP0437374
|
4-Oxopyrimidine, 31
Show/Hide
|
C19H12F3N5O
|
2
|
| 1 |
IC50 = 16 nM
|
|
|
| 2 |
IC50 = 63 nM
|
|
|
|
CP0460716
|
1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(2,3-dibromo-7-hydroxynaphthalen-1-yl)urea
Show/Hide
|
C18H10Br2ClF3N2O2
|
1
|
| 1 |
IC50 = 16 nM
|
|
|
|
CP0524603
|
1-(2,4-dichlorophenyl)-3-(7-hydroxynaphthalen-1-yl)urea
Show/Hide
|
C17H12Cl2N2O2
|
1
|
| 1 |
IC50 = 16 nM
|
|
|
|
CP0422342
|
(R)-N-(4-(6-(2-((1-isobutylpyrrolidin-2-yl)methylamino)-4-(trifluoromethyl)phenyl)pyrimidin-4-yloxy)benzo[d]thiazol-2-yl)acetamide
Show/Hide
|
C29H31F3N6O2S
|
1
|
| 1 |
IC50 = 17 nM
|
|
|
|
CP0492872
|
N-[4-({6-[4-(trifluoromethyl)piperidin-1-yl]pyrimidin-4-yl}oxy)-1,3-benzothiazol-2-yl]acetamide
Show/Hide
|
C19H18F3N5O2S
|
2
|
| 1 |
IC50 = 19 nM
|
|
|
| 2 |
IC50 = 330 nM
|
|
|
|
CP0395180
|
1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(7-methoxynaphthalen-1-yl)urea
Show/Hide
|
C19H14ClF3N2O2
|
1
|
| 1 |
IC50 = 19 nM
|
|
|
|
CP0459181
|
1-(7-hydroxynaphthalen-1-yl)-3-m-tolylurea
Show/Hide
|
C18H16N2O2
|
1
|
| 1 |
IC50 = 19 nM
|
|
|
|
CP0504350
|
1-(4-chloro-2-(trifluoromethyl)phenyl)-3-(7-hydroxynaphthalen-1-yl)urea
Show/Hide
|
C18H12ClF3N2O2
|
1
|
| 1 |
IC50 = 19 nM
|
|
|
|
CP0435897
|
N-{4-[(6-{4-[(1S)-1-(4-methoxyphenyl)ethyl]piperazin-1-yl}pyrimidin-4-yl)oxy]-1,3-benzothiazol-2-yl}acetamide
Show/Hide
|
C26H28N6O3S
|
2
|
| 1 |
IC50 = 20 nM
|
|
|
| 2 |
IC50 = 39 nM
|
|
|
|
CP0500427
|
N-[4-({6-[4-(diphenylmethyl)piperazin-1-yl]pyrimidin-4-yl}oxy)-1,3-benzothiazol-2-yl]acetamide
Show/Hide
|
C30H28N6O2S
|
2
|
| 1 |
IC50 = 20 nM
|
|
|
| 2 |
IC50 = 1400 nM
|
|
|
|
CP0435894
|
N-{4-[(6-{4-[(1S)-1-phenylpropyl]piperazin-1-yl}pyrimidin-4-yl)oxy]-1,3-benzothiazol-2-yl}acetamide
Show/Hide
|
C26H28N6O2S
|
2
|
| 1 |
IC50 = 20 nM
|
|
|
| 2 |
IC50 = 30 nM
|
|
|
|
CP0467008
|
4-piperidin-1-yl-6-(trifluoromethyl)-2-(4-(3-(trifluoromethyl)-pyridin-2-yl)piperazin-1-yl)-1H-benzo[d]imidazole
Show/Hide
|
C23H24F6N6
|
2
|
| 1 |
IC50 = 21 nM
|
|
|
| 2 |
IC50 = 29 nM
|
|
|
|
CP0514376
|
4-(3-(trifluoromethoxy)phenyl)-6-(trifluoromethyl)-2-(4-(3-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)-1H-benzo[d]-imidazole
Show/Hide
|
C25H18F9N5O
|
2
|
| 1 |
IC50 = 21 nM
|
|
|
| 2 |
IC50 = 26 nM
|
|
|
|
CP0494406
|
1-(3-fluorophenyl)-3-(7-hydroxynaphthalen-1-yl)urea
Show/Hide
|
C17H13FN2O2
|
1
|
| 1 |
IC50 = 21 nM
|
|
|
|
CP0461245
|
4-benzo[b]thiophen-2-yl-6-(trifluoromethyl)-2-(4-(3-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)-1H-benzo[d]imidazole
Show/Hide
|
C26H19F6N5S
|
2
|
| 1 |
IC50 = 22 nM
|
|
|
| 2 |
IC50 = 26 nM
|
|
|
|
CP0458518
|
(R)-(5-chloro-6-(3-methyl-4-(4-phenyl-5-(4-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)piperazin-1-yl)pyridin-3-yl)methanol
Show/Hide
|
C27H25ClF3N5O
|
2
|
| 1 |
IC50 = 26 nM
|
|
|
| 2 |
IC50 = 29 nM
|
|
|
|
CP0446065
|
6-(trifluoromethyl)-2-(4-(3-(trifluoromethyl)pyridin-2-yl)-piperazin-1-yl)-4-(3,4,5-trifluorophenyl)-1H-benzo[d]imidazole
Show/Hide
|
C24H16F9N5
|
2
|
| 1 |
IC50 = 26 nM
|
|
|
| 2 |
IC50 = 33 nM
|
|
|
|
CP0455053
|
1-(4-(2-acetamidobenzo[d]thiazol-4-yloxy)-6-(4-(trifluoromethyl)phenyl)pyrimidin-2-yl)piperidine-4-carboxylic acid
Show/Hide
|
C26H22F3N5O4S
|
2
|
| 1 |
IC50 = 27 nM
|
|
|
| 2 |
IC50 = 410 nM
|
|
|
|
CP0386531
|
(R)-5-chloro-6-(3-methyl-4-(6-(trifluoromethyl)-4-(3,4,5-trifluorophenyl)-1H-benzo[d]imidazol-2-yl)piperazin-1-yl)nicotinic acid
Show/Hide
|
C25H18ClF6N5O2
|
2
|
| 1 |
IC50 = 27 nM
|
|
|
| 2 |
IC50 = 46 nM
|
|
|
|
CP0372742
|
8-chloro-5-[[6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl]amino]-3,4-dihydro-2H-chromen-3-ol
Show/Hide
|
C20H15ClF3N3O2
|
1
|
| 1 |
IC50 = 28 nM
|
|
|
|
CP0522661
|
N-[4-({6-[4-(2-phenylpropan-2-yl)piperazin-1-yl]pyrimidin-4-yl}oxy)-1,3-benzothiazol-2-yl]acetamide
Show/Hide
|
C26H28N6O2S
|
2
|
| 1 |
IC50 = 29 nM
|
|
|
| 2 |
IC50 = 45 nM
|
|
|
|
CP0489308
|
N-[4-[5-methyl-6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl]oxy-1,3-benzothiazol-2-yl]acetamide
Show/Hide
|
C21H15F3N4O2S
|
2
|
| 1 |
IC50 = 30 nM
|
|
|
| 2 |
IC50 = 130 nM
|
|
|
|
CP0494347
|
1-(2,5-dichlorophenyl)-3-(7-hydroxynaphthalen-1-yl)urea
Show/Hide
|
C17H12Cl2N2O2
|
1
|
| 1 |
IC50 = 30 nM
|
|
|
|
CP0433243
|
N-[4-[2-(3-hydroxypiperidin-1-yl)-6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl]oxy-1,3-benzothiazol-2-yl]acetamide
Show/Hide
|
C25H22F3N5O3S
|
2
|
| 1 |
IC50 = 31 nM
|
|
|
| 2 |
IC50 = 39 nM
|
|
|
|
CP0490389
|
1-(4,5-bis(3,4,5-trifluorophenyl)-1H-imidazol-2-yl)-4-(3-(trifluoromethyl)pyridin-2-yl)piperazine
Show/Hide
|
C25H16F9N5
|
2
|
| 1 |
IC50 = 32 nM
|
|
|
| 2 |
IC50 = 44 nM
|
|
|
|
CP0527730
|
(R)-5-chloro-6-(4-(4-(4-fluorophenyl)-6-(trifluoromethyl)-1Hbenzo[d]imidazol-2-yl)-3-methylpiperazin-1-yl)pyridin-3-amine
Show/Hide
|
C24H21ClF4N6
|
2
|
| 1 |
IC50 = 33 nM
|
|
|
| 2 |
IC50 = 98 nM
|
|
|
|
CP0445205
|
3-Amino-5-(2-amino-6-(2-amino-4-(trifluoromethyl)phenyl)pyrimidin-4-yloxy)quinoxalin-2(1H)-one
Show/Hide
|
C19H14F3N7O2
|
2
|
| 1 |
IC50 = 34.5 nM
|
|
|
| 2 |
IC50 = 61.9 nM
|
|
|
|
CP0490393
|
1-(4-(3,5-difluorophenyl)-5-(4-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)-4-(3-(trifluoromethyl)pyridin-2-yl)piperazine
Show/Hide
|
C26H19F8N5
|
2
|
| 1 |
IC50 = 35 nM
|
|
|
| 2 |
IC50 = 85 nM
|
|
|
|
CP0560002
|
N-[4-[2-(4-hydroxypiperidin-1-yl)-6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl]oxy-1,3-benzothiazol-2-yl]acetamide
Show/Hide
|
C25H22F3N5O3S
|
2
|
| 1 |
IC50 = 35 nM
|
|
|
| 2 |
IC50 = 90 nM
|
|
|
|
CP0492890
|
4-Oxopyrimidine, 29c
Show/Hide
|
C21H15F3N4O
|
2
|
| 1 |
IC50 = 35 nM
|
|
|
| 2 |
IC50 = 43 nM
|
|
|
|
CP0528570
|
(R)-2-(2-methyl-4-(3-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)-6-(trifluoromethyl)-1H-benzo[d]imidazole
Show/Hide
|
C19H17F6N5
|
2
|
| 1 |
IC50 = 35 nM
|
|
|
| 2 |
IC50 = 48 nM
|
|
|
|
CP0467009
|
6-(trifluoromethyl)-4-(4-(trifluoromethyl)phenyl)-2-(4-(3-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)-1H-benzo[d]-imidazole
Show/Hide
|
C25H18F9N5
|
2
|
| 1 |
IC50 = 37 nM
|
|
|
| 2 |
IC50 = 51 nM
|
|
|
|
CP0459180
|
1-(2-chlorophenyl)-3-(7-hydroxynaphthalen-1-yl)urea
Show/Hide
|
C17H13ClN2O2
|
1
|
| 1 |
IC50 = 38 nM
|
|
|
|
CP0500429
|
N-(4-{[6-(4-benzylpiperazin-1-yl)pyrimidin-4-yl]oxy}-1,3-benzothiazol-2-yl)acetamide
Show/Hide
|
C24H24N6O2S
|
2
|
| 1 |
IC50 = 39 nM
|
|
|
| 2 |
IC50 = 93 nM
|
|
|
|
CP0502615
|
1-(3-acetylphenyl)-3-(7-hydroxynaphthalen-1-yl)urea
Show/Hide
|
C19H16N2O3
|
1
|
| 1 |
IC50 = 39 nM
|
|
|
|
CP0433211
|
6-fluoro-8-[[6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl]amino]-1,2,3,4-tetrahydronaphthalen-2-ol
Show/Hide
|
C21H17F4N3O
|
1
|
| 1 |
IC50 = 43 nM
|
|
|
|
CP0503947
|
5-bromo-6-(trifluoromethyl)-2-(4-(3-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)-1H-benzo[d]imidazole
Show/Hide
|
C18H14BrF6N5
|
2
|
| 1 |
IC50 = 43 nM
|
|
|
| 2 |
IC50 = 166 nM
|
|
|
|
CP0537907
|
4-morpholino-6-(trifluoromethyl)-2-(4-(3-(trifluoromethyl)-pyridin-2-yl)piperazin-1-yl)-1H-benzo[d]imidazole
Show/Hide
|
C22H22F6N6O
|
2
|
| 1 |
IC50 = 50 nM
|
|
|
| 2 |
IC50 = 95 nM
|
|
|
|
CP0454097
|
N-[4-[2-[[1-(2-methylpropyl)piperidin-4-yl]methylamino]-6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl]oxy-1,3-benzothiazol-2-yl]acetamide
Show/Hide
|
C30H33F3N6O2S
|
2
|
| 1 |
IC50 = 51 nM
|
|
|
| 2 |
IC50 = 64 nM
|
|
|
|
CP0527737
|
4-pyrazin-2-yl-6-(trifluoromethyl)-2-(4-(3-(trifluoromethyl)-pyridin-2-yl)piperazin-1-yl)-1H-benzo[d]imidazole
Show/Hide
|
C22H17F6N7
|
2
|
| 1 |
IC50 = 51 nM
|
|
|
| 2 |
IC50 = 129 nM
|
|
|
|
CP0525922
|
4-(3,4-difluorobenzyl)-6-(trifluoromethyl)-2-(4-(3-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)-1H-benzo[d]imidazole
Show/Hide
|
C25H19F8N5
|
2
|
| 1 |
IC50 = 52 nM
|
|
|
| 2 |
IC50 = 71 nM
|
|
|
|
CP0434048
|
2-[(4-tert-butylphenyl)methyl]-3-({[(3-fluoro-4-methanesulfonamidophenyl)methyl]carbamothioyl}amino)propyl 2,2-dimethylpropanoate
Show/Hide
|
C28H40FN3O4S2
|
3
|
| 1 |
IC50 = 52 nM
|
|
|
| 2 |
Ki = 22.6 nM
|
|
|
| 3 |
Ki = 52 nM
|
|
|
|
CP0476847
|
3-(7-hydroxynaphthalen-1-yl)-1-phenylurea
Show/Hide
|
C17H14N2O2
|
1
|
| 1 |
IC50 = 53 nM
|
|
|
|
CP0481278
|
N-[4-[6-[2-[2-(dimethylamino)ethylamino]-6-(trifluoromethyl)pyridin-3-yl]pyrimidin-4-yl]oxy-1,3-benzothiazol-2-yl]acetamide
Show/Hide
|
C23H22F3N7O2S
|
1
|
| 1 |
IC50 = 63 nM
|
|
|
|
CP0527051
|
(5-chloro-6-(4-(6-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)piperazin-1-yl)pyridin-3-yl)methanol
Show/Hide
|
C18H17ClF3N5O
|
2
|
| 1 |
IC50 = 64 nM
|
|
|
| 2 |
IC50 = 98 nM
|
|
|
|
CP0494405
|
1-(7-hydroxynaphthalen-1-yl)-3-(2-(trifluoromethyl)phenyl)urea
Show/Hide
|
C18H13F3N2O2
|
1
|
| 1 |
IC50 = 64 nM
|
|
|
|
CP0441833
|
2-(4-(trifluoromethyl)phenyl)-6-(3-(trifluoromethyl)pyridin-2-yl)-1,2-dihydroindazol-3-one
Show/Hide
|
C20H11F6N3O
|
2
|
| 1 |
IC50 = 65 nM
|
|
|
| 2 |
IC50 = 220 nM
|
|
|
|
CP0118931
|
2,2-Dimethyl-propionic acid 2-(3,4-dimethyl-benzyl)-3-[3-(4-methanesulfonylamino-benzyl)-thioureido]-propyl ester
Show/Hide
|
C26H37N3O4S2
|
3
|
| 1 |
IC50 = 67 nM
|
|
|
| 2 |
Ki = 29.3 nM
|
|
|
| 3 |
Ki = 67 nM
|
|
|
|
CP0464546
|
4-phenyl-6-(trifluoromethyl)-2-(4-(3-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)-1H-benzo[d]imidazole
Show/Hide
|
C24H19F6N5
|
2
|
| 1 |
IC50 = 68 nM
|
|
|
| 2 |
IC50 = 141 nM
|
|
|
|
CP0541347
|
N,N-dimethyl-4-[6-(trifluoromethyl)-2-[4-[3-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]-1H-benzimidazol-4-yl]aniline
Show/Hide
|
C26H24F6N6
|
2
|
| 1 |
IC50 = 69 nM
|
|
|
| 2 |
IC50 = 108 nM
|
|
|
|
CP0461247
|
4-bromo-6-(trifluoromethyl)-2-(4-(3-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)-1H-benzo[d]imidazole
Show/Hide
|
C18H14BrF6N5
|
2
|
| 1 |
IC50 = 74 nM
|
|
|
| 2 |
IC50 = 131 nM
|
|
|
|
CP0528566
|
(S)-2-(4-(3-bromopyridin-2-yl)-2-methylpiperazin-1-yl)-6-(trifluoromethyl)-4-(3,4,5-trifluorophenyl)-1H-benzo[d]imidazole
Show/Hide
|
C24H18BrF6N5
|
2
|
| 1 |
IC50 = 75 nM
|
|
|
| 2 |
IC50 = 104 nM
|
|
|
|
CP0208692
|
(2E)-3-(4-tert-butylphenyl)-N-(2,3-dihydro-1,4-benzodioxin-6-yl)prop-2-enamide
Show/Hide
|
C21H23NO3
|
2
|
| 1 |
IC50 = 79 nM
|
|
|
| 2 |
IC50 = 350 nM
|
|
|
|
CP0446064
|
6-(trifluoromethyl)-2-[4-[3-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]-N-[(3,4,5-trifluorophenyl)methyl]-1H-benzimidazol-4-amine
Show/Hide
|
C25H19F9N6
|
2
|
| 1 |
IC50 = 81 nM
|
|
|
| 2 |
IC50 = 132 nM
|
|
|
|
CP0445647
|
6-tert-Butyl-2-[4-(3-chloro-pyridin-2-yl)-piperazin-1-yl]-1H-benzoimidazole
Show/Hide
|
C20H24ClN5
|
2
|
| 1 |
IC50 = 87 nM
|
|
|
| 2 |
IC50 = 310 nM
|
|
|
|
CP0490392
|
(5-chloro-6-(4-(4-phenyl-5-(4-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)piperazin-1-yl)pyridin-3-yl)methanol
Show/Hide
|
C26H23ClF3N5O
|
2
|
| 1 |
IC50 = 90 nM
|
|
|
| 2 |
IC50 = 160 nM
|
|
|
|
CP0433241
|
N-[4-[5-amino-6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl]oxy-1,3-benzothiazol-2-yl]acetamide
Show/Hide
|
C20H14F3N5O2S
|
2
|
| 1 |
IC50 = 93 nM
|
|
|
| 2 |
IC50 = 240 nM
|
|
|
|
CP0451806
|
6-(trifluoromethyl)-N-[[4-(trifluoromethyl)phenyl]methyl]-2-[4-[3-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]-1H-benzimidazol-5-amine
Show/Hide
|
C26H21F9N6
|
2
|
| 1 |
IC50 = 94 nM
|
|
|
| 2 |
IC50 = 141 nM
|
|
|
|
CP0395225
|
2,2-Dimethyl-propionic acid 2-(3,4-dimethyl-benzyl)-3-[3-(2-chloro-4-methanesulfonylamino-benzyl)-thioureido-N-hydroxy]-propyl ester
Show/Hide
|
C26H36FN3O5S2
|
2
|
| 1 |
IC50 = 94 nM
|
|
|
| 2 |
Ki = 212 nM
|
|
|
|
CP0514375
|
4-(6-methoxypyridin-3-yl)-6-(trifluoromethyl)-2-(4-(3-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)-1H-benzo[d]imidazole
Show/Hide
|
C24H20F6N6O
|
2
|
| 1 |
IC50 = 99 nM
|
|
|
| 2 |
IC50 = 111 nM
|
|
|
|
CP0522373
|
N-[4-[2-[1-(2-methylpropyl)piperidin-4-yl]-6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl]oxy-1,3-benzothiazol-2-yl]acetamide
Show/Hide
|
C29H30F3N5O2S
|
1
|
| 1 |
IC50 = 100 nM
|
|
|
|
CP0458517
|
1-(4-phenyl-5-(4-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)-4-(3-(trifluoromethyl)pyridin-2-yl)piperazine
Show/Hide
|
C26H21F6N5
|
2
|
| 1 |
IC50 = 107 nM
|
|
|
| 2 |
IC50 = 216 nM
|
|
|
|
CP0461648
|
6-(trifluoromethyl)-2-(4-(3-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)-1H-benzo[d]imidazole
Show/Hide
|
C18H15F6N5
|
2
|
| 1 |
IC50 = 110 nM
|
|
|
| 2 |
IC50 = 301 nM
|
|
|
|
CP0541654
|
(R)-2-methyl-1-(4-phenyl-5-(4-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)-4-(3-(trifluoromethyl)pyridin-2-yl)piperazine
Show/Hide
|
C27H23F6N5
|
2
|
| 1 |
IC50 = 117 nM
|
|
|
| 2 |
IC50 = 341 nM
|
|
|
|
CP0437364
|
6-(4-tert-butylphenyl)-N-(2,3-dihydro-1,4-benzodioxin-6-yl)pyrimidin-4-amine
Show/Hide
|
C22H23N3O2
|
2
|
| 1 |
IC50 = 120 nM
|
|
|
| 2 |
IC50 = 680 nM
|
|
|
|
CP0529369
|
4-Oxopyrimidine, 28c
Show/Hide
|
C20H12F3N3O
|
2
|
| 1 |
IC50 = 120 nM
|
|
|
| 2 |
IC50 > 4000 nM
|
|
|
|
CP0461755
|
4-Oxopyrimidine, 28b
Show/Hide
|
C20H12F3N3O
|
2
|
| 1 |
IC50 = 120 nM
|
|
|
| 2 |
IC50 = 150 nM
|
|
|
|
CP0500430
|
N-[4-({6-[4-(2,2,2-trifluoroethyl)piperazin-1-yl]pyrimidin-4-yl}oxy)-1,3-benzothiazol-2-yl]acetamide
Show/Hide
|
C19H19F3N6O2S
|
2
|
| 1 |
IC50 = 120 nM
|
|
|
| 2 |
IC50 = 380 nM
|
|
|
|
CP0464342
|
4,6-bis(trifluoromethyl)-2-(4-(3-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)-1H-benzo[d]imidazole
Show/Hide
|
C19H14F9N5
|
2
|
| 1 |
IC50 = 120 nM
|
|
|
| 2 |
IC50 = 325 nM
|
|
|
|
CP0386529
|
6-bromo-2-(4-(3-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)-1H-benzo[d]imidazole
Show/Hide
|
C17H15BrF3N5
|
2
|
| 1 |
IC50 = 123 nM
|
|
|
| 2 |
IC50 = 194 nM
|
|
|
|
CP0403069
|
N-[2-[6-[(2-acetamido-1,3-benzothiazol-4-yl)oxy]pyrimidin-4-yl]-5-(trifluoromethyl)phenyl]-3-(dimethylamino)propanamide
Show/Hide
|
C25H23F3N6O3S
|
1
|
| 1 |
IC50 = 130 nM
|
|
|
|
CP0897741
|
(E)-4-styryl-6-(trifluoromethyl)-2-(4-(3-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)-1H-benzo[d]imidazole
Show/Hide
|
C26H21F6N5
|
2
|
| 1 |
IC50 = 140 nM
|
|
|
| 2 |
IC50 = 185 nM
|
|
|
|
CP0511588
|
1-(4,5-bis(4-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)-4-(3-(trifluoromethyl)pyridin-2-yl)piperazine
Show/Hide
|
C27H20F9N5
|
2
|
| 1 |
IC50 = 146 nM
|
|
|
| 2 |
IC50 = 573 nM
|
|
|
|
CP0378464
|
2-[(3,4-dimethylphenyl)methyl]-3-[1-(3-fluoro-4-methanesulfonamidophenyl)acetamido]propyl 2,2-dimethylpropanoate
Show/Hide
|
C26H35FN2O5S
|
3
|
| 1 |
IC50 = 150 nM
|
|
|
| 2 |
Ki = 151 nM
|
|
|
| 3 |
Ki = 157 nM
|
|
|
|
CP0511587
|
1-(4-chloro-5-(4-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)-4-(3-(trifluoromethyl)pyridin-2-yl)piperazine
Show/Hide
|
C20H16ClF6N5
|
2
|
| 1 |
IC50 = 160 nM
|
|
|
| 2 |
IC50 > 4000 nM
|
|
|
|
CP0522834
|
1-(4-phenyl-5-(3-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)-4-(3-(trifluoromethyl)pyridin-2-yl)piperazine
Show/Hide
|
C26H21F6N5
|
2
|
| 1 |
IC50 = 165 nM
|
|
|
| 2 |
IC50 = 1235 nM
|
|
|
|
CP0397334
|
2,2-Dimethyl-propionic acid 2-(3,4-dimethyl-benzyl)-3-(3-fluoro-4-methanesulfonylamino-benzyloxythiocarbonylamino)-propyl ester
Show/Hide
|
C26H35FN2O5S2
|
2
|
| 1 |
IC50 = 170 nM
|
|
|
| 2 |
Ki = 210 nM
|
|
|
|
CP0528072
|
methyl 4-[4-(trifluoromethyl)phenyl]-2-[4-[3-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]-1H-imidazole-5-carboxylate
Show/Hide
|
C22H19F6N5O2
|
2
|
| 1 |
IC50 = 180 nM
|
|
|
| 2 |
IC50 = 1170 nM
|
|
|
|
CP0541348
|
6-tert-butyl-2-(4-(3-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)-1H-benzo[d]imidazole
Show/Hide
|
C21H24F3N5
|
2
|
| 1 |
IC50 = 183 nM
|
|
|
| 2 |
IC50 = 282 nM
|
|
|
|
CP0456929
|
4-pyridin-4-yl-6-(trifluoromethyl)-2-(4-(3-(trifluoromethyl)-pyridin-2-yl)piperazin-1-yl)-1H-benzo[d]imidazole
Show/Hide
|
C23H18F6N6
|
2
|
| 1 |
IC50 = 188 nM
|
|
|
| 2 |
IC50 = 267 nM
|
|
|
|
CP0455052
|
N-[4-[2-(1,2,3,6-tetrahydropyridin-4-yl)-6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl]oxy-1,3-benzothiazol-2-yl]acetamide
Show/Hide
|
C25H20F3N5O2S
|
2
|
| 1 |
IC50 = 190 nM
|
|
|
| 2 |
IC50 = 910 nM
|
|
|
|
CP0412687
|
5-[[6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl]amino]-3,4-dihydro-2H-chromen-3-ol
Show/Hide
|
C20H16F3N3O2
|
1
|
| 1 |
IC50 = 190 nM
|
|
|
|
CP0537909
|
6-(trifluoromethyl)-5-(4-(trifluoromethyl)phenyl)-2-(4-(3-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)-1H-benzo[d]imidazole
Show/Hide
|
C25H18F9N5
|
2
|
| 1 |
IC50 = 201 nM
|
|
|
| 2 |
IC50 = 8240 nM
|
|
|
|
CP0427670
|
N-[4-[6-[2-[3-(dimethylamino)propylamino]-6-(trifluoromethyl)pyridin-3-yl]pyrimidin-4-yl]oxy-1,3-benzothiazol-2-yl]acetamide
Show/Hide
|
C24H24F3N7O2S
|
1
|
| 1 |
IC50 = 210 nM
|
|
|
|
CP0448187
|
2,2-Dimethyl-propionic acid 2-(3,4-dimethyl-benzyl)-3-[3-4-methanesulfonylamino-benzyl)-thioureido-N-hydroxy]-propyl ester
Show/Hide
|
C26H37N3O5S2
|
2
|
| 1 |
IC50 = 212 nM
|
|
|
| 2 |
Ki = 1042 nM
|
|
|
|
CP0464547
|
2-(4-(3-iodopyridin-2-yl)piperazin-1-yl)-6-(trifluoromethyl)-1H-benzo[d]imidazole
Show/Hide
|
C17H15F3IN5
|
2
|
| 1 |
IC50 = 221 nM
|
|
|
| 2 |
IC50 = 310 nM
|
|
|
|
CP0537908
|
4-thiophen-2-yl-6-(trifluoromethyl)-2-(4-(3-(trifluoromethyl)-pyridin-2-yl)piperazin-1-yl)-1H-benzo[d]imidazole
Show/Hide
|
C22H17F6N5S
|
2
|
| 1 |
IC50 = 221 nM
|
|
|
| 2 |
IC50 = 373 nM
|
|
|
|
CP0500420
|
4-(4-tert-butylphenyl)-N-(2,3-dihydro-1,4-benzodioxin-6-yl)pyridin-2-amine
Show/Hide
|
C23H24N2O2
|
2
|
| 1 |
IC50 = 230 nM
|
|
|
| 2 |
IC50 = 1300 nM
|
|
|
|
CP0453718
|
(S)-2-(4-(3-bromopyridin-2-yl)-3-methylpiperazin-1-yl)-6-(trifluoromethyl)-4-(3,4,5-trifluorophenyl)-1H-benzo[d]imidazole
Show/Hide
|
C24H18BrF6N5
|
2
|
| 1 |
IC50 = 254 nM
|
|
|
| 2 |
IC50 = 767 nM
|
|
|
|
CP0395177
|
3-(3-(7-hydroxynaphthalen-1-yl)ureido)benzoic acid
Show/Hide
|
C18H14N2O4
|
1
|
| 1 |
IC50 = 270 nM
|
|
|
|
CP0384476
|
(S)-N-(4-(6-(2-(((1-isobutylpyrrolidin-2-yl)methyl)(methyl)amino)-4-(trifluoromethyl)phenyl)pyrimidin-4-yloxy)benzo[d]thiazol-2-yl)acetamide
Show/Hide
|
C30H33F3N6O2S
|
1
|
| 1 |
IC50 = 280 nM
|
|
|
|
CP0433963
|
4-(4-tert-butylphenyl)-6-(2,3-dihydro-1,4-benzodioxin-6-yloxy)pyrimidine
Show/Hide
|
C22H22N2O3
|
2
|
| 1 |
IC50 = 290 nM
|
|
|
| 2 |
IC50 = 670 nM
|
|
|
|
CP0525924
|
4-(6-(trifluoromethyl)-2-(4-(3-(trifluoromethyl)pyridin-2-yl)-piperazin-1-yl)-1H-benzo[d]imidazol-4-yl)benzenamine
Show/Hide
|
C24H20F6N6
|
2
|
| 1 |
IC50 = 308 nM
|
|
|
| 2 |
IC50 = 1900 nM
|
|
|
|
CP0528565
|
2-(4-(3-chloropyridin-2-yl)piperazin-1-yl)-6-(trifluoromethyl)-1H-benzo[d]imidazole
Show/Hide
|
C17H15ClF3N5
|
2
|
| 1 |
IC50 = 309 nM
|
|
|
| 2 |
IC50 = 705 nM
|
|
|
|
CP0401555
|
2,2-Dimethyl-propionic acid 2-(3,4-dimethyl-benzyl)-3-[3-(4-methanesulfonylamino-benzyl)-thioureido-N-hydroxy]-propyl ester
Show/Hide
|
C26H37N3O5S2
|
2
|
| 1 |
IC50 = 331 nM
|
|
|
| 2 |
Ki = 481 nM
|
|
|
|
CP0372061
|
6-(3,4-difluorophenyl)-2-(4-(3-(trifluoromethyl)pyridin-2-yl)-piperazin-1-yl)-1H-benzo[d]imidazole
Show/Hide
|
C23H18F5N5
|
2
|
| 1 |
IC50 = 351 nM
|
|
|
| 2 |
IC50 = 1140 nM
|
|
|
|
CP0467007
|
2-(4-(3-methylpyridin-2-yl)piperazin-1-yl)-6-(trifluoromethyl)-1H-benzo[d]imidazole
Show/Hide
|
C18H18F3N5
|
2
|
| 1 |
IC50 = 402 nM
|
|
|
| 2 |
IC50 = 1140 nM
|
|
|
|
CP0451807
|
6-(trifluoromethyl)-2-(4-(2-(trifluoromethyl)phenyl)piperazin-1-yl)-1H-benzo[d]imidazole
Show/Hide
|
C19H16F6N4
|
2
|
| 1 |
IC50 = 406 nM
|
|
|
| 2 |
IC50 = 2060 nM
|
|
|
|
CP0377432
|
N-(2,3-dihydro-1,4-benzodioxin-6-yl)-6-[4-(trifluoromethyl)phenyl]pyrimidin-4-amine
Show/Hide
|
C19H14F3N3O2
|
2
|
| 1 |
IC50 = 430 nM
|
|
|
| 2 |
IC50 = 1200 nM
|
|
|
|
CP0448889
|
5-chloro-6-(4-(6-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)-piperazin-1-yl)nicotinamide
Show/Hide
|
C18H16ClF3N6O
|
2
|
| 1 |
IC50 = 430 nM
|
|
|
| 2 |
IC50 = 1000 nM
|
|
|
|
CP0436331
|
2-[(4-tert-butylphenyl)methyl]-3-[1-(3-fluoro-4-methanesulfonamidophenyl)acetamido]propyl 2,2-dimethylpropanoate
Show/Hide
|
C28H39FN2O5S
|
3
|
| 1 |
IC50 = 440 nM
|
|
|
| 2 |
Ki = 74 nM
|
|
|
| 3 |
Ki = 440 nM
|
|
|
|
CP0439591
|
2,2-Dimethyl-propionic acid 2-(3,4-dimethyl-benzyl)-3-(4-methanesulfonylamino-benzyloxythiocarbonylamino)-propyl ester
Show/Hide
|
C26H36N2O5S2
|
2
|
| 1 |
IC50 = 440 nM
|
|
|
| 2 |
Ki = 336 nM
|
|
|
|
CP0451809
|
4-thiazol-2-yl-6-(trifluoromethyl)-2-(4-(3-(trifluoromethyl)-pyridin-2-yl)piperazin-1-yl)-1H-benzo[d]imidazole
Show/Hide
|
C21H16F6N6S
|
2
|
| 1 |
IC50 = 454 nM
|
|
|
| 2 |
IC50 = 688 nM
|
|
|
|
CP0500421
|
4-Oxopyrimidine, 27a
Show/Hide
|
C20H12F3N3O
|
2
|
| 1 |
IC50 = 460 nM
|
|
|
| 2 |
IC50 > 4000 nM
|
|
|
|
CP0395283
|
2,2-Dimethyl-propionic acid 2-(3,4-dimethyl-benzyl)-3-[2-(4-methanesulfonylamino-phenyl)-acetylamino]-propyl ester
Show/Hide
|
C26H36N2O5S
|
2
|
| 1 |
IC50 = 460 nM
|
|
|
| 2 |
Ki = 500 nM
|
|
|
|
CP0449500
|
(R,S)-1-(5-chloro-6-(4-(6-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)piperazin-1-yl)pyridin-3-yl)ethanol
Show/Hide
|
C19H19ClF3N5O
|
2
|
| 1 |
IC50 = 461 nM
|
|
|
| 2 |
IC50 = 652 nM
|
|
|
|
CP0464542
|
5-chloro-N-methyl-6-(4-(6-(trifluoromethyl)-1H-benzo[d]-imidazol-2-yl)piperazin-1-yl)nicotinamide
Show/Hide
|
C19H18ClF3N6O
|
2
|
| 1 |
IC50 = 493 nM
|
|
|
| 2 |
IC50 > 40000 nM
|
|
|
|
CP0427672
|
N-[2-[6-[(2-acetamido-1,3-benzothiazol-4-yl)oxy]pyrimidin-4-yl]-5-(trifluoromethyl)phenyl]-4-(dimethylamino)butanamide
Show/Hide
|
C26H25F3N6O3S
|
1
|
| 1 |
IC50 = 520 nM
|
|
|
|
CP0502616
|
1-(3-(hydroxymethyl)phenyl)-3-(7-hydroxynaphthalen-1-yl)urea
Show/Hide
|
C18H16N2O3
|
1
|
| 1 |
IC50 = 520 nM
|
|
|
|
CP0514377
|
1-(5-chloro-6-(4-(5-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)piperazin-1-yl)pyridin-3-yl)ethanone
Show/Hide
|
C19H17ClF3N5O
|
2
|
| 1 |
IC50 = 581 nM
|
|
|
| 2 |
IC50 = 832 nM
|
|
|
|
CP0458519
|
1-(4-methyl-5-(4-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)-4-(3-(trifluoromethyl)pyridin-2-yl)piperazine
Show/Hide
|
C21H19F6N5
|
2
|
| 1 |
IC50 = 628 nM
|
|
|
| 2 |
IC50 > 4000 nM
|
|
|
|
CP0500424
|
3-({6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl}oxy)isoquinoline
Show/Hide
|
C20H12F3N3O
|
2
|
| 1 |
IC50 = 630 nM
|
|
|
| 2 |
IC50 > 4000 nM
|
|
|
|
CP0461653
|
(R)-2-(2-ethyl-4-(3-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)-6-(trifluoromethyl)-1H-benzo[d]imidazole
Show/Hide
|
C20H19F6N5
|
2
|
| 1 |
IC50 = 648 nM
|
|
|
| 2 |
IC50 > 4000 nM
|
|
|
|
CP0433240
|
N-[4-[5-(dimethylamino)-6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl]oxy-1,3-benzothiazol-2-yl]acetamide
Show/Hide
|
C22H18F3N5O2S
|
2
|
| 1 |
IC50 = 660 nM
|
|
|
| 2 |
IC50 > 4000 nM
|
|
|
|
CP0492889
|
4-Oxopyrimidine, 28d
Show/Hide
|
C20H12F3N3O
|
2
|
| 1 |
IC50 = 660 nM
|
|
|
| 2 |
IC50 > 4000 nM
|
|
|
|
CP0460715
|
1-(3-(1-hydroxyethyl)phenyl)-3-(7-hydroxynaphthalen-1-yl)urea
Show/Hide
|
C19H18N2O3
|
1
|
| 1 |
IC50 = 670 nM
|
|
|
|
CP0490391
|
(4-isopropylpiperazin-1-yl)(5-(4-(trifluoromethyl)phenyl)-2-(4-(3-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)-1H-imidazol-4-yl)methanone
Show/Hide
|
C28H31F6N7O
|
2
|
| 1 |
IC50 = 700 nM
|
|
|
| 2 |
IC50 = 1000 nM
|
|
|
|
CP0461727
|
2-({6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl}oxy)quinoline
Show/Hide
|
C20H12F3N3O
|
2
|
| 1 |
IC50 = 730 nM
|
|
|
| 2 |
IC50 > 4000 nM
|
|
|
|
CP0383730
|
2,2-Dimethyl-propionic acid 2-(3,4-dimethyl-benzyl)-3-[3-(2-chloro-4-methanesulfonylamino-benzyl)-thioureido-N-hydroxy]-propyl ester
Show/Hide
|
C26H36ClN3O5S2
|
2
|
| 1 |
IC50 = 757 nM
|
|
|
| 2 |
Ki = 220 nM
|
|
|
|
CP0522660
|
4-(4-tert-butylphenyl)-N-(2,3-dihydro-1,4-benzodioxin-6-yl)-1,3,5-triazin-2-amine
Show/Hide
|
C21H22N4O2
|
2
|
| 1 |
IC50 = 760 nM
|
|
|
| 2 |
IC50 > 4000 nM
|
|
|
|
CP0437362
|
5-(4-tert-butylphenyl)-N-(2,3-dihydro-1,4-benzodioxin-6-yl)pyridazin-3-amine
Show/Hide
|
C22H23N3O2
|
2
|
| 1 |
IC50 = 780 nM
|
|
|
| 2 |
IC50 > 4000 nM
|
|
|
|
CP0377429
|
6-(4-tert-butylphenyl)-N-(2,3-dihydro-1,4-benzodioxin-6-yl)pyridazin-4-amine
Show/Hide
|
C22H23N3O2
|
2
|
| 1 |
IC50 = 840 nM
|
|
|
| 2 |
IC50 > 4000 nM
|
|
|
|
CP0492880
|
4-Oxopyrimidine, 26
Show/Hide
|
C21H15F3N4O2S
|
2
|
| 1 |
IC50 = 860 nM
|
|
|
| 2 |
IC50 > 4000 nM
|
|
|
|
CP0458593
|
1-(5-(4-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)-4-(3-(trifluoromethyl)pyridin-2-yl)piperazine
Show/Hide
|
C20H17F6N5
|
2
|
| 1 |
IC50 = 861 nM
|
|
|
| 2 |
IC50 > 4000 nM
|
|
|
|
CP0461246
|
4-nitro-6-(trifluoromethyl)-2-(4-(3-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)-1H-benzo[d]imidazole
Show/Hide
|
C18H14F6N6O2
|
2
|
| 1 |
IC50 = 878 nM
|
|
|
| 2 |
IC50 = 1660 nM
|
|
|
|
CP0528571
|
6-(trifluoromethyl)-2-(4-(3-(trifluoromethyl)pyridin-2-yl)-piperazin-1-yl)-1H-imidazo[4,5-b]pyridine
Show/Hide
|
C17H14F6N6
|
2
|
| 1 |
IC50 = 884 nM
|
|
|
| 2 |
IC50 = 1550 nM
|
|
|
|
CP0435883
|
4-(4-tert-butylphenyl)-6-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)pyrimidine
Show/Hide
|
C23H24N2O2
|
2
|
| 1 |
IC50 = 914 nM
|
|
|
| 2 |
IC50 > 4000 nM
|
|
|
|
CP0503946
|
5-(trifluoromethyl)-2-(4-(3-(trifluoromethyl)pyridin-2-yl)-piperazin-1-yl)-3H-imidazo[4,5-b]pyridine
Show/Hide
|
C17H14F6N6
|
2
|
| 1 |
IC50 = 1090 nM
|
|
|
| 2 |
IC50 = 1410 nM
|
|
|
|
CP0500425
|
4-Oxopyrimidine, 24
Show/Hide
|
C21H15F3N4O2S
|
2
|
| 1 |
IC50 = 1100 nM
|
|
|
| 2 |
IC50 = 1500 nM
|
|
|
|
CP0372060
|
6-chloro-2-[4-(3-trifluoromethylpyridin-2-yl)piperazin-1-yl]-1H-benzo[d]imidazole
Show/Hide
|
C17H15ClF3N5
|
2
|
| 1 |
IC50 = 1130 nM
|
|
|
| 2 |
IC50 = 17250 nM
|
|
|
|
CP0461764
|
5-(4-tert-butylphenyl)-N-(2,3-dihydro-1,4-benzodioxin-6-yl)pyridin-3-amine
Show/Hide
|
C23H24N2O2
|
2
|
| 1 |
IC50 = 1210 nM
|
|
|
| 2 |
IC50 > 4000 nM
|
|
|
|
CP0461656
|
methyl 2-[4-[3-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]-3H-benzimidazole-5-carboxylate
Show/Hide
|
C19H18F3N5O2
|
2
|
| 1 |
IC50 = 1230 nM
|
|
|
| 2 |
IC50 > 4000 nM
|
|
|
|
CP0464340
|
2-(4-(2,6-dichlorophenyl)piperazin-1-yl)-6-(trifluoromethyl)-1H-benzo[d]imidazole
Show/Hide
|
C18H15Cl2F3N4
|
2
|
| 1 |
IC50 = 1270 nM
|
|
|
| 2 |
IC50 > 40000 nM
|
|
|
|
CP0437379
|
N-[4-({6-[4-(propan-2-yl)piperazin-1-yl]pyrimidin-4-yl}oxy)-1,3-benzothiazol-2-yl]acetamide
Show/Hide
|
C20H24N6O2S
|
2
|
| 1 |
IC50 = 1300 nM
|
|
|
| 2 |
IC50 > 4000 nM
|
|
|
|
CP0456933
|
2-(4-(3,5-dichloropyridin-4-yl)piperazin-1-yl)-6-(trifluoromethyl)-1H-benzo[d]imidazole
Show/Hide
|
C17H14Cl2F3N5
|
2
|
| 1 |
IC50 = 1370 nM
|
|
|
| 2 |
IC50 = 1990 nM
|
|
|
|
CP0461767
|
4-Oxopyrimidine, 27b
Show/Hide
|
C20H12F3N3O
|
2
|
| 1 |
IC50 = 1400 nM
|
|
|
| 2 |
IC50 > 4000 nM
|
|
|
|
CP0435895
|
N-(4-{[6-(4-tert-butylpiperazin-1-yl)pyrimidin-4-yl]oxy}-1,3-benzothiazol-2-yl)acetamide
Show/Hide
|
C21H26N6O2S
|
2
|
| 1 |
IC50 = 1500 nM
|
|
|
| 2 |
IC50 > 4000 nM
|
|
|
|
CP0501913
|
N-[[1-(2-methylpropyl)piperidin-2-yl]methyl]-4-[4-(trifluoromethyl)phenyl]-2-[4-[3-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]-1H-imidazole-5-carboxamide
Show/Hide
|
C31H37F6N7O
|
2
|
| 1 |
IC50 = 1900 nM
|
|
|
| 2 |
IC50 > 4000 nM
|
|
|
|
CP0514393
|
2-(4-(5-chloropyrimidin-4-yl)piperazin-1-yl)-6-(trifluoromethyl)-1H-benzo[d]imidazole
Show/Hide
|
C16H14ClF3N6
|
2
|
| 1 |
IC50 = 2110 nM
|
|
|
| 2 |
IC50 > 40000 nM
|
|
|
|
CP0437363
|
6-(4-tert-butylphenyl)-N-(2,3-dihydro-1,4-benzodioxin-6-yl)-N-methylpyrimidin-4-amine
Show/Hide
|
C23H25N3O2
|
2
|
| 1 |
IC50 = 2200 nM
|
|
|
| 2 |
IC50 > 4000 nM
|
|
|
|
CP0386525
|
6-(trifluoromethyl)-2-(4-(3-(trifluoromethyl)pyridin-4-yl)-piperazin-1-yl)-1H-benzo[d]imidazole
Show/Hide
|
C18H15F6N5
|
2
|
| 1 |
IC50 = 2380 nM
|
|
|
| 2 |
IC50 = 2850 nM
|
|
|
|
CP0492886
|
4-({6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl}oxy)isoquinoline
Show/Hide
|
C20H12F3N3O
|
2
|
| 1 |
IC50 = 2900 nM
|
|
|
| 2 |
IC50 > 4000 nM
|
|
|
|
CP0438933
|
N-(piperidin-2-ylmethyl)-4-[4-(trifluoromethyl)phenyl]-2-[4-[3-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]-1H-imidazole-5-carboxamide
Show/Hide
|
C27H29F6N7O
|
2
|
| 1 |
IC50 = 2950 nM
|
|
|
| 2 |
IC50 > 4000 nM
|
|
|
|
CP0453742
|
(R)-2-(2-propyl-4-(3-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)-6-(trifluoromethyl)-1H-benzo[d]imidazole
Show/Hide
|
C21H21F6N5
|
2
|
| 1 |
IC50 = 3230 nM
|
|
|
| 2 |
IC50 > 4000 nM
|
|
|
|
CP0522835
|
N-[(1-ethylpyrrolidin-2-yl)methyl]-4-[4-(trifluoromethyl)phenyl]-2-[4-[3-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]-1H-imidazole-5-carboxamide
Show/Hide
|
C28H31F6N7O
|
2
|
| 1 |
IC50 = 3300 nM
|
|
|
| 2 |
IC50 = 4100 nM
|
|
|
|
CP0464343
|
2-(4-(3-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)-3H-benzo[d]imidazole-5-carbonitrile
Show/Hide
|
C18H15F3N6
|
2
|
| 1 |
IC50 = 3300 nM
|
|
|
| 2 |
IC50 > 4000 nM
|
|
|
|
CP0940311
|
6-methyl-2-(4-(3-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)-1H-benzo[d]imidazole hydrochloride
Show/Hide
|
C18H19ClF3N5
|
2
|
| 1 |
IC50 = 3350 nM
|
|
|
| 2 |
IC50 > 4000 nM
|
|
|
|
CP0461655
|
6-(trifluoromethyl)-2-(4-(3-(trifluoromethyl)pyridin-2-yl)-piperazin-1-yl)-1H-benzo[d]imidazol-4-amine
Show/Hide
|
C18H16F6N6
|
2
|
| 1 |
IC50 = 3380 nM
|
|
|
| 2 |
IC50 > 4000 nM
|
|
|
|
CP0409616
|
2,2-Dimethyl-propionic acid 2-(3,4-dimethyl-benzyl)-3-[2-(4-methanesulfonylamino-phenyl)-acetoxy]-propyl ester
Show/Hide
|
C26H35NO6S
|
2
|
| 1 |
IC50 = 3602 nM
|
|
|
| 2 |
Ki = 1980 nM
|
|
|
|
CP0500428
|
N-[4-({6-[4-(2-phenylethyl)piperazin-1-yl]pyrimidin-4-yl}oxy)-1,3-benzothiazol-2-yl]acetamide
Show/Hide
|
C25H26N6O2S
|
2
|
| 1 |
IC50 = 3700 nM
|
|
|
| 2 |
IC50 > 4000 nM
|
|
|
|
CP0528564
|
2-(4-(3-chloropyridin-4-yl)piperazin-1-yl)-6-(trifluoromethyl)-1H-benzo[d]imidazole
Show/Hide
|
C17H15ClF3N5
|
2
|
| 1 |
IC50 = 3910 nM
|
|
|
| 2 |
IC50 = 8030 nM
|
|
|
|
CP0461650
|
2-(4-pyridin-2-ylpiperazin-1-yl)-6-(trifluoromethyl)-1H-benzo[d]imidazole
Show/Hide
|
C17H16F3N5
|
2
|
| 1 |
IC50 = 5790 nM
|
|
|
| 2 |
IC50 > 40000 nM
|
|
|
|
CP0537911
|
2-(4-(6-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)piperazin-1-yl)nicotinonitrile
Show/Hide
|
C18H15F3N6
|
2
|
| 1 |
IC50 = 6290 nM
|
|
|
| 2 |
IC50 = 7080 nM
|
|
|
|
CP0451575
|
2,2-Dimethyl-propionic acid 2-(4-tert-butyl-benzyl)-3-[3-(3-fluoro-4-methanesulfonylamino-benzyl)-thioureido-N-hydroxy]-propyl ester
Show/Hide
|
C28H40FN3O5S2
|
2
|
| 1 |
IC50 = 10100 nM
|
|
|
| 2 |
Ki = 405 nM
|
|
|
|
CP0464544
|
6-(trifluoromethyl)-2-(4-(5-(trifluoromethyl)pyridin-2-yl)-piperazin-1-yl)-1 H-benzo[d]imidazole
Show/Hide
|
C18H15F6N5
|
2
|
| 1 |
IC50 = 11290 nM
|
|
|
| 2 |
IC50 > 40000 nM
|
|
|
|
CP0453717
|
6-(trifluoromethyl)-2-(4-(4-(trifluoromethyl)pyridin-2-yl)-piperazin-1-yl)-1H-benzo[d]imidazole
Show/Hide
|
C18H15F6N5
|
2
|
| 1 |
IC50 = 11930 nM
|
|
|
| 2 |
IC50 > 5640 nM
|
|
|
|
CP0464543
|
ethyl 2-[4-[6-(trifluoromethyl)-1H-benzimidazol-2-yl]piperazin-1-yl]pyridine-3-carboxylate
Show/Hide
|
C20H20F3N5O2
|
2
|
| 1 |
IC50 = 23780 nM
|
|
|
| 2 |
IC50 > 40000 nM
|
|
|
|
CP0386526
|
6-(trifluoromethyl)-2-(4-(6-(trifluoromethyl)pyridin-2-yl)-piperazin-1-yl)-1H-benzo[d]imidazole
Show/Hide
|
C18H15F6N5
|
1
|
| 1 |
IC50 > 40000 nM
|
|
|
|
CP0498645
|
1-(3-fluorophenyl)-3-(3-hydroxybenzyl)urea
Show/Hide
|
C14H13FN2O2
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0503177
|
1-(2,6-dichlorophenyl)-3-(7-hydroxynaphthalen-1-yl)urea
Show/Hide
|
C17H12Cl2N2O2
|
1
|
| 1 |
IC50 > 1000 nM
|
|
|
|
CP0481280
|
N-[2-[6-[(2-acetamido-1,3-benzothiazol-4-yl)oxy]pyrimidin-4-yl]-5-(trifluoromethyl)phenyl]-2-aminoacetamide
Show/Hide
|
C22H17F3N6O3S
|
1
|
| 1 |
IC50 > 4000 nM
|
|
|
|
CP0464432
|
4-(4-tert-butylphenyl)-6-(2,3-dihydro-1,4-benzodioxin-6-ylsulfanyl)pyrimidine
Show/Hide
|
C22H22N2O2S
|
1
|
| 1 |
IC50 > 4000 nM
|
|
|
|
CP0500418
|
4-(4-tert-butylphenyl)-N-(2,3-dihydro-1,4-benzodioxin-6-yl)pyrimidin-2-amine
Show/Hide
|
C22H23N3O2
|
1
|
| 1 |
IC50 > 4000 nM
|
|
|
|
CP0520484
|
N-[3-(4-tert-butylphenyl)phenyl]-2,3-dihydro-1,4-benzodioxin-6-amine
Show/Hide
|
C24H25NO2
|
1
|
| 1 |
IC50 > 4000 nM
|
|
|
|
CP0530850
|
2-(4-tert-butylphenyl)-N-(2,3-dihydro-1,4-benzodioxin-6-yl)pyrimidin-4-amine
Show/Hide
|
C22H23N3O2
|
1
|
| 1 |
IC50 > 4000 nM
|
|
|
|
CP0435880
|
2-(4-tert-butylphenyl)-N-(2,3-dihydro-1,4-benzodioxin-6-yl)pyridin-4-amine
Show/Hide
|
C23H24N2O2
|
1
|
| 1 |
IC50 > 4000 nM
|
|
|
|
CP0461762
|
6-(4-tert-butylphenyl)-N-(2,3-dihydro-1,4-benzodioxin-6-yl)pyridin-2-amine
Show/Hide
|
C23H24N2O2
|
1
|
| 1 |
IC50 > 4000 nM
|
|
|
|
CP0461763
|
(3E)-3-[(4-tert-butylphenyl)methylidene]-1-(2,3-dihydro-1,4-benzodioxin-6-yl)piperidin-2-one
Show/Hide
|
C24H27NO3
|
1
|
| 1 |
IC50 > 4000 nM
|
|
|
|
CP0461766
|
3-[(4-tert-butylphenyl)methyl]-1-(2,3-dihydro-1,4-benzodioxin-6-yl)-1,2-dihydropyridin-2-one
Show/Hide
|
C24H25NO3
|
1
|
| 1 |
IC50 > 4000 nM
|
|
|
|
CP0500419
|
6-(4-tert-butylphenyl)-N-(2,3-dihydro-1,4-benzodioxin-6-yl)pyrazin-2-amine
Show/Hide
|
C22H23N3O2
|
1
|
| 1 |
IC50 > 4000 nM
|
|
|
|
CP0437366
|
1-({6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl}oxy)isoquinoline
Show/Hide
|
C20H12F3N3O
|
1
|
| 1 |
IC50 > 4000 nM
|
|
|
|
CP0492879
|
4-Oxopyrimidine, 27c
Show/Hide
|
C20H12F3N3O
|
1
|
| 1 |
IC50 > 4000 nM
|
|
|
|
CP0492881
|
2-methoxy-8-({6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl}oxy)quinoline
Show/Hide
|
C21H14F3N3O2
|
1
|
| 1 |
IC50 > 4000 nM
|
|
|
|
CP0461754
|
4-({6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl}oxy)quinoline
Show/Hide
|
C20H12F3N3O
|
1
|
| 1 |
IC50 > 4000 nM
|
|
|
|
CP0461768
|
3-({6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl}oxy)quinoline
Show/Hide
|
C20H12F3N3O
|
1
|
| 1 |
IC50 > 4000 nM
|
|
|
|
CP0492883
|
2-methyl-N-[4-({6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl}oxy)-1,3-benzothiazol-2-yl]propanamide
Show/Hide
|
C22H17F3N4O2S
|
1
|
| 1 |
IC50 > 4000 nM
|
|
|
|
CP0492884
|
4-Oxopyrimidine, 29d
Show/Hide
|
C22H17F3N4O
|
1
|
| 1 |
IC50 > 4000 nM
|
|
|
|
CP0492885
|
4-Oxopyrimidine, 29a
Show/Hide
|
C20H12F3N3O2
|
1
|
| 1 |
IC50 > 4000 nM
|
|
|
|
CP0500422
|
3-amino-8-({6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl}oxy)-1,2-dihydroquinoxalin-2-one
Show/Hide
|
C19H12F3N5O2
|
1
|
| 1 |
IC50 > 4000 nM
|
|
|
|
CP0433961
|
N-(4-{[6-(morpholin-4-yl)pyrimidin-4-yl]oxy}-1,3-benzothiazol-2-yl)acetamide
Show/Hide
|
C17H17N5O3S
|
1
|
| 1 |
IC50 > 4000 nM
|
|
|
|
CP0437378
|
N-(4-{[6-(piperazin-1-yl)pyrimidin-4-yl]oxy}-1,3-benzothiazol-2-yl)acetamide
Show/Hide
|
C17H18N6O2S
|
1
|
| 1 |
IC50 > 4000 nM
|
|
|
|
CP0464548
|
6-fluoro-2-(4-(3-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)-1H-benzo[d]imidazole
Show/Hide
|
C17H15F4N5
|
1
|
| 1 |
IC50 > 4000 nM
|
|
|
|
CP0312254
|
US9120756, 17
Show/Hide
|
C24H28ClFN4O3S
|
1
|
| 1 |
Ki = 0.1 nM
|
|
|
|
CP0451014
|
US9120756, 26
Show/Hide
|
C21H19ClF4N4O3S
|
1
|
| 1 |
Ki = 0.1 nM
|
|
|
|
CP0470506
|
[(2R,6R,10S,15S,17R)-13-benzyl-6-hydroxy-4,17-dimethyl-5-oxo-15-prop-1-en-2-yl-12,14,18-trioxapentacyclo[11.4.1.01,10.02,6.011,15]octadeca-3,8-dien-8-yl]methyl 2-(3-bromo-4-hydroxy-5-methoxyphenyl)acetate
Show/Hide
|
C37H39BrO9
|
2
|
| 1 |
Ki = 0.17 nM
|
|
|
| 2 |
Ki = 7.2 nM
|
|
|
|
CP0523990
|
[(2R,6R,10S,15S,17R)-13-benzyl-6-hydroxy-4,17-dimethyl-5-oxo-15-prop-1-en-2-yl-12,14,18-trioxapentacyclo[11.4.1.01,10.02,6.011,15]octadeca-3,8-dien-8-yl]methyl 2-(4-acetyloxy-3-bromo-5-methoxyphenyl)acetate
Show/Hide
|
C39H41BrO10
|
1
|
| 1 |
Ki = 0.3 nM
|
|
|
|
CP0407831
|
(2R)-2-[(4-tert-butylphenyl)methyl]-3-[(2S)-2-(3-fluoro-4-methanesulfonamidophenyl)propanamido]propyl 2,2-dimethylpropanoate
Show/Hide
|
C29H41FN2O5S
|
2
|
| 1 |
Ki = 0.58 nM
|
|
|
| 2 |
Ki = 4.12 nM
|
|
|
|
CP0407829
|
[(1R,2R,6R,10S,11R,13S,15R,17R)-13-benzyl-6-hydroxy-4,17-dimethyl-5-oxo-15-prop-1-en-2-yl-12,14,18-trioxapentacyclo[11.4.1.01,10.02,6.011,15]octadeca-3,8-dien-8-yl]methyl 2-(4-hydroxy-3-iodo-5-methoxyphenyl)acetate
Show/Hide
|
C37H39IO9
|
2
|
| 1 |
Ki = 0.61 nM
|
|
|
| 2 |
Ki = 12.2 nM
|
|
|
|
CP0425732
|
2-iodo Resiniferatoxin
Show/Hide
|
C37H39IO9
|
2
|
| 1 |
Ki = 0.61 nM
|
|
|
| 2 |
Ki = 12.2 nM
|
|
|
|
CP0373236
|
[(2R,6R,10S,15S,17R)-13-benzyl-6-hydroxy-4,17-dimethyl-5-oxo-15-prop-1-en-2-yl-12,14,18-trioxapentacyclo[11.4.1.01,10.02,6.011,15]octadeca-3,8-dien-8-yl]methyl 2-(4-amino-3-chloro-5-methoxyphenyl)acetate
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C37H40ClNO8
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1
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| 1 |
Ki = 0.85 nM
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CP0396016
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[(1R,2R,6R,10S,11R,13S,15R,17R)-13-benzyl-6-hydroxy-4,17-dimethyl-5-oxo-15-prop-1-en-2-yl-12,14,18-trioxapentacyclo[11.4.1.01,10.02,6.011,15]octadeca-3,8-dien-8-yl]methyl (3-bromo-4-hydroxy-5-methoxyphenyl) carbonate
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C36H37BrO10
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3
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| 1 |
Ki = 1.64 nM
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| 2 |
Ki = 5.2 nM
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| 3 |
Ki = 26.2 nM
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CP0404347
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[(1R,2R,6R,10S,11R,13S,15R,17R)-13-benzyl-6-hydroxy-4,17-dimethyl-5-oxo-15-prop-1-en-2-yl-12,14,18-trioxapentacyclo[11.4.1.01,10.02,6.011,15]octadeca-3,8-dien-8-yl]methyl (3-chloro-4-hydroxy-5-methoxyphenyl) carbonate
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C36H37ClO10
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2
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| 1 |
Ki = 1.64 nM
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| 2 |
Ki = 21.3 nM
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CP0386210
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[(1R,2R,6R,10S,11R,13S,15R,17R)-13-benzyl-6-hydroxy-4,17-dimethyl-5-oxo-15-prop-1-en-2-yl-12,14,18-trioxapentacyclo[11.4.1.01,10.02,6.011,15]octadeca-3,8-dien-8-yl]methyl (4-hydroxy-3-iodo-5-methoxyphenyl) carbonate
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C36H37IO10
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2
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| 1 |
Ki = 1.66 nM
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| 2 |
Ki = 2.23 nM
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CP0403112
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(2R)-2-[(4-tert-butylphenyl)methyl]-3-[(2S)-2-(3-chloro-4-methanesulfonamidophenyl)propanamido]propyl 2,2-dimethylpropanoate
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C29H41ClN2O5S
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2
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| 1 |
Ki = 1.83 nM
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| 2 |
Ki = 5.2 nM
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CP0386211
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(4-amino-3-bromo-5-methoxyphenyl) [(1R,2R,6R,10S,11R,13S,15R,17R)-13-benzyl-6-hydroxy-4,17-dimethyl-5-oxo-15-prop-1-en-2-yl-12,14,18-trioxapentacyclo[11.4.1.01,10.02,6.011,15]octadeca-3,8-dien-8-yl]methyl carbonate
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C36H38BrNO9
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2
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| 1 |
Ki = 1.83 nM
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| 2 |
Ki = 2.46 nM
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CP0374420
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5-bromo-4-amino Resiniferatoxin
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C37H40BrNO8
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2
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| 1 |
Ki = 1.99 nM
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| 2 |
Ki = 2.81 nM
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CP0397471
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(4-amino-3-chloro-5-methoxyphenyl) [(1R,2R,6R,10S,11R,13S,15R,17R)-13-benzyl-6-hydroxy-4,17-dimethyl-5-oxo-15-prop-1-en-2-yl-12,14,18-trioxapentacyclo[11.4.1.01,10.02,6.011,15]octadeca-3,8-dien-8-yl]methyl carbonate
Show/Hide
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C36H38ClNO9
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2
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| 1 |
Ki = 2.5 nM
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| 2 |
Ki = 4.06 nM
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CP0406395
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(4-amino-3-iodo-5-methoxyphenyl) [(1R,2R,6R,10S,11R,13S,15R,17R)-13-benzyl-6-hydroxy-4,17-dimethyl-5-oxo-15-prop-1-en-2-yl-12,14,18-trioxapentacyclo[11.4.1.01,10.02,6.011,15]octadeca-3,8-dien-8-yl]methyl carbonate
Show/Hide
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C36H38INO9
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2
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| 1 |
Ki = 2.68 nM
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| 2 |
Ki = 3.01 nM
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CP0469643
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2-(4-tert-Butylbenzyl)-3-[2-(4-hydroxy-3-iodo-5-methoxyphenyl)acetamido]propyl pivalate
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C28H38INO5
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2
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| 1 |
Ki = 2.8 nM
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| 2 |
Ki = 22 nM
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CP0412387
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2-[(4-tert-butylphenyl)methyl]-3-[2-(3-fluoro-4-methanesulfonamidophenyl)propanamido]propyl 2,2-dimethylpropanoate
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C29H41FN2O5S
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2
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| 1 |
Ki = 3.24 nM
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| 2 |
Ki = 13.6 nM
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CP0372359
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(2S)-2-[(4-tert-butylphenyl)methyl]-3-[(2S)-2-(3-chloro-4-methanesulfonamidophenyl)propanamido]propyl 2,2-dimethylpropanoate
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C29H41ClN2O5S
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2
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| 1 |
Ki = 3.29 nM
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| 2 |
Ki = 12.1 nM
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CP0400122
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2-(4-tert-Butylbenzyl)-3-[2-(4-amino-3-bromo-5-methoxyphenyl)acetamido]propyl pivalate
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C28H39BrN2O4
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2
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| 1 |
Ki = 3.4 nM
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| 2 |
Ki = 79.1 nM
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CP0464917
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2-[(4-tert-butylphenyl)methyl]-3-[2-(3-chloro-4-methanesulfonamidophenyl)propanamido]propyl 2,2-dimethylpropanoate
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C29H41ClN2O5S
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2
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| 1 |
Ki = 3.6 nM
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| 2 |
Ki = 12.3 nM
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CP0493390
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2-(4-tert-Butylbenzyl)-3-[2-(4-amino-3,5-dichlorophenyl)acetamido]propyl pivalate
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C27H36Cl2N2O3
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2
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| 1 |
Ki = 3.96 nM
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| 2 |
Ki = 9.43 nM
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CP0398156
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2-(4-tert-Butylbenzyl)-3-[2-(4-amino-3-chloro-5-methoxyphenyl)acetamido]propyl pivalate
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C28H39ClN2O4
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2
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| 1 |
Ki = 4.09 nM
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| 2 |
Ki = 33.5 nM
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CP0409393
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(2S)-N-[(4-tert-butylphenyl)methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
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C21H27FN2O3S
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2
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| 1 |
Ki = 4.16 nM
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| 2 |
Ki = 24.4 nM
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CP0493389
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2-(4-tert-Butylbenzyl)-3-[2-(3,5-dichloro-4-hydroxyphenyl)acetamido]propyl pivalate
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C27H35Cl2NO4
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2
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| 1 |
Ki = 4.26 nM
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| 2 |
Ki = 9.3 nM
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CP0493391
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2-(4-tert-Butylbenzyl)-3-[2-(4-amino-3,5-dibromophenyl)acetamido]propyl pivalate
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C27H36Br2N2O3
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2
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| 1 |
Ki = 4.3 nM
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| 2 |
Ki = 11.3 nM
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CP0407471
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3-[(4-tert-butylphenyl)methyl]-1-[(1R)-1-(4-methanesulfonamidophenyl)ethyl]thiourea
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C21H29N3O2S2
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2
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| 1 |
Ki = 4.5 nM
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| 2 |
Ki = 41 nM
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CP0372358
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(2S)-2-[(4-tert-butylphenyl)methyl]-3-[(2S)-2-(3-fluoro-4-methanesulfonamidophenyl)propanamido]propyl 2,2-dimethylpropanoate
Show/Hide
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C29H41FN2O5S
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2
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| 1 |
Ki = 6.26 nM
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| 2 |
Ki = 10.9 nM
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CP0396410
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[2-[(3,4-dimethylphenyl)methyl]-3-[[(1R)-1-[4-(methanesulfonamido)phenyl]ethyl]carbamothioylamino]propyl] 2,2-dimethylpropanoate
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C27H39N3O4S2
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1
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| 1 |
Ki = 6.9 nM
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CP0086118
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[(2R)-2-[(3,4-dimethylphenyl)methyl]-3-[[(1R)-1-[4-(methanesulfonamido)phenyl]ethyl]carbamothioylamino]propyl] 2,2-dimethylpropanoate
Show/Hide
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C27H39N3O4S2
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1
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| 1 |
Ki = 7.1 nM
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CP0437736
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2-[3-bromo-4-(methanesulfonamido)phenyl]-N-[(4-tert-butylphenyl)methyl]propanamide
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C21H27BrN2O3S
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2
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| 1 |
Ki = 7.4 nM
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| 2 |
Ki = 25 nM
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CP0463132
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N-[(4-tert-butylphenyl)methyl]-2-[3,5-difluoro-4-(methanesulfonamido)phenyl]propanamide
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C21H26F2N2O3S
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2
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| 1 |
Ki = 7.4 nM
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| 2 |
Ki = 19.9 nM
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CP0394930
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N-[(4-tert-butylphenyl)methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
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C21H27FN2O3S
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2
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| 1 |
Ki = 7.6 nM
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| 2 |
Ki = 46.2 nM
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CP0484768
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N-[3,3-bis(4-methylphenyl)prop-2-enyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
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C27H29FN2O3S
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2
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| 1 |
Ki = 8 nM
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| 2 |
Ki = 30.9 nM
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CP0378462
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(2R)-2-benzyl-3-[(2S)-2-(3-fluoro-4-methanesulfonamidophenyl)propanamido]propyl 2,2-dimethylpropanoate
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C25H33FN2O5S
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2
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| 1 |
Ki = 8.56 nM
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| 2 |
Ki = 43 nM
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CP0502846
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2-(4-tert-Butylbenzyl)-3-[2-(3-bromo-4-hydroxy-5-methoxyphenyl)acetamido]propyl pivalate
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C28H38BrNO5
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2
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| 1 |
Ki = 8.77 nM
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| 2 |
Ki = 9.4 nM
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CP0407472
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3-[(4-tert-butylphenyl)methyl]-1-[(3-fluoro-4-methanesulfonamidophenyl)methyl]thiourea
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C20H26FN3O2S2
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3
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| 1 |
Ki = 9.16 nM
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| 2 |
Ki = 9.2 nM
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| 3 |
Ki = 53.5 nM
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CP0435885
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3-[(4-tert-butylphenyl)methyl]-1-[1-(3-fluoro-4-methanesulfonamidophenyl)ethyl]thiourea
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C21H28FN3O2S2
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2
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| 1 |
Ki = 9.2 nM
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| 2 |
Ki = 54 nM
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CP0436352
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(2S)-2-benzyl-3-[(2S)-2-(3-fluoro-4-methanesulfonamidophenyl)propanamido]propyl 2,2-dimethylpropanoate
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C25H33FN2O5S
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2
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| 1 |
Ki = 10 nM
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| 2 |
Ki = 16.5 nM
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CP0496606
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2-(4-tert-Butylbenzyl)-3-[2-(3,5-dibromo-4-hydroxyphenyl)acetamido]propyl pivalate
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C27H35Br2NO4
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2
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| 1 |
Ki = 10.7 nM
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| 2 |
Ki = 20.2 nM
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CP0516542
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2-[(3,4-dimethylphenyl)methyl]-3-[2-(3-fluoro-4-methanesulfonamidophenyl)propanamido]propyl 2,2-dimethylpropanoate
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C27H37FN2O5S
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2
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| 1 |
Ki = 10.8 nM
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| 2 |
Ki = 33.1 nM
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CP0464920
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3-[2-(3-chloro-4-methanesulfonamidophenyl)propanamido]-2-[(3,4-dimethylphenyl)methyl]propyl 2,2-dimethylpropanoate
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C27H37ClN2O5S
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2
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| 1 |
Ki = 11.3 nM
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| 2 |
Ki = 36 nM
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CP0372039
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2-((3-(2-chloro-4-hydroxy-5-methoxybenzyl)thioureido)methyl)-3-(4-tert-butylphenyl)propyl pivalate
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C28H39ClN2O4S
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1
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| 1 |
Ki = 12.2 nM
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CP0427615
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N-[(2-bromo-4-tert-butylphenyl)methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
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C21H26BrFN2O3S
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2
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| 1 |
Ki = 12.7 nM
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| 2 |
Ki = 47 nM
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CP0399735
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2-((3-(2-bromo-4-hydroxy-5-methoxybenzyl)thioureido)methyl)-3-(4-tert-butylphenyl)propyl pivalate
Show/Hide
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C28H39BrN2O4S
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2
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| 1 |
Ki = 12.8 nM
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| 2 |
Ki = 55 nM
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CP0396411
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[(2S)-2-[(3,4-dimethylphenyl)methyl]-3-[[(1R)-1-[4-(methanesulfonamido)phenyl]ethyl]carbamothioylamino]propyl] 2,2-dimethylpropanoate
Show/Hide
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C27H39N3O4S2
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1
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| 1 |
Ki = 13.2 nM
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CP0495750
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2-((3-(4-hydroxy-2-iodo-5-methoxybenzyl)thioureido)methyl)-3-(4-tert-butylphenyl)propyl pivalate
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C28H39IN2O4S
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2
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| 1 |
Ki = 13.3 nM
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| 2 |
Ki = 71 nM
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CP0479099
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2-(4-tert-Butylbenzyl)-3-[2-(4-hydroxy-2-iodo-5-methoxyphenyl)acetamido]propyl pivalate
Show/Hide
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C28H38INO5
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2
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| 1 |
Ki = 13.5 nM
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| 2 |
Ki = 20.9 nM
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CP0399582
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2-[(3,4-dimethylphenyl)methyl]-3-[2-(4-methanesulfonamido-3-methoxyphenyl)propanamido]propyl 2,2-dimethylpropanoate
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C28H40N2O6S
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2
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| 1 |
Ki = 13.6 nM
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| 2 |
Ki = 71 nM
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CP0425797
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2-(4-tert-Butylbenzyl)-3-[2-(4-acetoxy-3-bromo-5-methoxyphenyl)acetamido]propyl pivalate
Show/Hide
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C30H40BrNO6
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2
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| 1 |
Ki = 13.6 nM
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| 2 |
Ki = 72 nM
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CP0405363
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N-(3,3-diphenylprop-2-enyl)-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
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C25H25FN2O3S
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2
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| 1 |
Ki = 14.2 nM
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| 2 |
Ki = 21.5 nM
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CP0464440
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3-[(4-tert-butylphenyl)methyl]-1-[1-(4-methanesulfonamidophenyl)ethyl]thiourea
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C21H29N3O2S2
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2
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| 1 |
Ki = 14.7 nM
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| 2 |
Ki = 59.3 nM
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CP0427620
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N-[(4-cyclopent-2-en-1-ylphenyl)methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
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C22H25FN2O3S
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2
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| 1 |
Ki = 15 nM
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| 2 |
Ki = 162 nM
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CP0506386
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N-[(4-tert-butylphenyl)methyl]-2-(4-hydroxy-3-iodo-5-methoxyphenyl)acetamide
Show/Hide
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C20H24INO3
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2
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| 1 |
Ki = 17.2 nM
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| 2 |
Ki = 89 nM
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CP0426252
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N-[(4-tert-butylphenyl)methyl]-2-[4-(methanesulfonamido)phenyl]propanamide
Show/Hide
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C21H28N2O3S
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2
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| 1 |
Ki = 17.5 nM
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| 2 |
Ki = 106 nM
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CP0434045
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2-((3-(3-bromo-4-hydroxy-5-methoxybenzyl)thioureido)methyl)-3-(4-tert-butylphenyl)propyl pivalate
Show/Hide
|
C28H39BrN2O4S
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1
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| 1 |
Ki = 18.8 nM
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CP0490620
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2-((3-(4-hydroxy-2-iodo-5-methoxybenzyl)thioureido)methyl)-3-(3,4-dimethylphenyl)propyl pivalate
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C26H35IN2O4S
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2
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| 1 |
Ki = 18.9 nM
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| 2 |
Ki = 23.1 nM
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CP0475857
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N-[(4-tert-butylphenyl)methyl]-2-[4-(methanesulfonamido)-3-methylphenyl]propanamide
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C22H30N2O3S
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2
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| 1 |
Ki = 18.9 nM
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| 2 |
Ki = 32.8 nM
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CP0501334
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2-(4-tert-Butylbenzyl)-3-[2-(4-acetoxy-3-iodo-5-methoxyphenyl)acetamido]propyl pivalate
Show/Hide
|
C30H40INO6
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2
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| 1 |
Ki = 19.1 nM
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| 2 |
Ki = 20.3 nM
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CP0496625
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2-(4-tert-Butylbenzyl)-3-[2-(4-acetoxy-2-iodo-5-methoxyphenyl)acetamido]propyl pivalate
Show/Hide
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C30H40INO6
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2
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| 1 |
Ki = 19.5 nM
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| 2 |
Ki = 53 nM
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CP0501727
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2-((3-(2-bromo-4-hydroxy-5-methoxybenzyl)thioureido)methyl)-3-(3,4-dimethylphenyl)propyl pivalate
Show/Hide
|
C26H35BrN2O4S
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1
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| 1 |
Ki = 19.9 nM
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CP0427621
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N-[(4-cyclopentylphenyl)methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
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C22H27FN2O3S
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2
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| 1 |
Ki = 20.8 nM
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| 2 |
Ki = 93 nM
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CP0506387
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2-(4-tert-Butylbenzyl)-3-[2-(4-acetoxy-3-chloro-5-methoxyphenyl)acetamido]propyl pivalate
Show/Hide
|
C30H40ClNO6
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1
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| 1 |
Ki = 21 nM
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CP0504954
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2-((3-(3-chloro-4-hydroxy-5-methoxybenzyl)thioureido)methyl)-3-(4-tert-butylphenyl)propyl pivalate
Show/Hide
|
C28H39ClN2O4S
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1
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| 1 |
Ki = 21.3 nM
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CP0409376
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N-[(4-tert-butylphenyl)methyl]-2-[3-iodo-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C21H27IN2O3S
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2
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| 1 |
Ki = 23.3 nM
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| 2 |
Ki = 30 nM
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CP0495416
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(E)-3-(4-tert-butylphenyl)-N-[1-[3-fluoro-4-(methanesulfonamido)phenyl]ethyl]prop-2-enamide
Show/Hide
|
C22H27FN2O3S
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2
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| 1 |
Ki = 23.9 nM
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| 2 |
Ki = 105 nM
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CP0468548
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[2-[(4-tert-butylphenyl)methyl]-3-[[(1R)-1-[4-(methanesulfonamido)phenyl]ethyl]carbamothioylamino]propyl] 2,2-dimethylpropanoate
Show/Hide
|
C29H43N3O4S2
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1
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| 1 |
Ki = 23.9 nM
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CP0490576
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2-[(4-tert-butylphenyl)methyl]-3-[2-(4-methanesulfonamido-3-methoxyphenyl)propanamido]propyl 2,2-dimethylpropanoate
Show/Hide
|
C30H44N2O6S
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1
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| 1 |
Ki = 24 nM
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CP0495749
|
2-((3-(2-chloro-4-hydroxy-5-methoxybenzyl)thioureido)methyl)-3-(3,4-dimethylphenyl)propyl pivalate
Show/Hide
|
C26H35ClN2O4S
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1
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| 1 |
Ki = 24.2 nM
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CP0441314
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N-[3,3-bis(4-chlorophenyl)prop-2-enyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
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C25H23Cl2FN2O3S
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2
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| 1 |
Ki = 24.5 nM
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| 2 |
Ki = 29.6 nM
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CP0484772
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N-[3,3-bis(4-fluorophenyl)propyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
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C25H25F3N2O3S
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2
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| 1 |
Ki = 24.8 nM
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| 2 |
Ki = 79 nM
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CP0398038
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2-(4-tert-Butylbenzyl)-3-[2-(4-acetoxy-2-chloro-5-methoxyphenyl)acetamido]propyl pivalate
Show/Hide
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C30H40ClNO6
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1
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| 1 |
Ki = 25.1 nM
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CP0469645
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3-[2-(3-Bromo-4-hydroxyphenyl)acetamido]-2-(4-tertbutylbenzyl)propyl pivalate
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C27H36BrNO4
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1
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| 1 |
Ki = 25.1 nM
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CP0386387
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2-(4-tert-Butylbenzyl)-3-[2-(2-bromo-4-hydroxy-5-methoxyphenyl)acetamido]propyl pivalate
Show/Hide
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C28H38BrNO5
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1
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| 1 |
Ki = 25.3 nM
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CP0116650
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[2-[(3,4-dimethylphenyl)methyl]-3-[1-[4-(methanesulfonamido)phenyl]ethylcarbamothioylamino]propyl] 2,2-dimethylpropanoate
Show/Hide
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C27H39N3O4S2
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1
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| 1 |
Ki = 25.9 nM
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CP0391645
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1-[(4-tert-butylphenyl)methyl]-3-[[2-fluoro-4-(methanesulfonamido)phenyl]methyl]thiourea
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C20H26FN3O2S2
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2
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| 1 |
Ki = 27.3 nM
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| 2 |
Ki = 215 nM
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CP0433965
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3-[(4-tert-butylphenyl)methyl]-1-[1-(4-methanesulfonamido-3-methoxyphenyl)ethyl]thiourea
Show/Hide
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C22H31N3O3S2
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2
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| 1 |
Ki = 28.6 nM
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| 2 |
Ki = 67 nM
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CP0302905
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[2-[(4-tert-butylphenyl)methyl]-3-[1-[4-(methanesulfonamido)phenyl]ethylcarbamothioylamino]propyl] 2,2-dimethylpropanoate
Show/Hide
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C29H43N3O4S2
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1
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| 1 |
Ki = 28.7 nM
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CP0439846
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N-[3,3-bis(4-fluorophenyl)prop-2-enyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
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C25H23F3N2O3S
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2
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| 1 |
Ki = 29.2 nM
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| 2 |
Ki = 43.3 nM
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CP0426255
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N-[(4-tert-butylphenyl)methyl]-2-[3-chloro-4-(methanesulfonamido)phenyl]propanamide
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C21H27ClN2O3S
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2
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| 1 |
Ki = 29.5 nM
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| 2 |
Ki = 30.7 nM
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CP0399725
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1-(2-bromo-4-hydroxy-5-methoxybenzyl)-3-(4-tert-butylbenzyl)thiourea
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C20H25BrN2O2S
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2
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| 1 |
Ki = 30.3 nM
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| 2 |
Ki = 42.1 nM
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CP0436374
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(2R)-2-[(4-tert-butylphenyl)methyl]-3-[(2R)-2-(3-fluoro-4-methanesulfonamidophenyl)propanamido]propyl 2,2-dimethylpropanoate
Show/Hide
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C29H41FN2O5S
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2
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| 1 |
Ki = 30.3 nM
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| 2 |
Ki = 53 nM
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CP0086120
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[(2S)-2-[(4-tert-butylphenyl)methyl]-3-[[(1R)-1-[4-(methanesulfonamido)phenyl]ethyl]carbamothioylamino]propyl] 2,2-dimethylpropanoate
Show/Hide
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C29H43N3O4S2
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1
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| 1 |
Ki = 30.6 nM
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CP0501271
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2-((3-(3-chloro-4-hydroxy-5-methoxybenzyl)thioureido)methyl)-3-(3,4-dimethylphenyl)propyl pivalate
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C26H35ClN2O4S
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1
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| 1 |
Ki = 30.9 nM
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CP0504657
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2-(4-tert-Butylbenzyl)-3-[2-(3-chloro-4-hydroxy-5-methoxyphenyl)acetamido]propyl pivalate
Show/Hide
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C28H38ClNO5
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1
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| 1 |
Ki = 31 nM
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CP0448135
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2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[3-(4-fluorophenyl)-3-(4-methylphenyl)propyl]propanamide
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C26H28F2N2O3S
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2
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| 1 |
Ki = 31 nM
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| 2 |
Ki = 121 nM
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CP0393080
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N-[3,3-bis(4-methylphenyl)propyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
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C27H31FN2O3S
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2
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| 1 |
Ki = 32.1 nM
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| 2 |
Ki = 96 nM
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CP0399733
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2-((3-(3-bromo-4-hydroxy-5-methoxybenzyl)thioureido)methyl)-3-(3,4-dimethylphenyl)propyl pivalate
Show/Hide
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C26H35BrN2O4S
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1
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| 1 |
Ki = 33.1 nM
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CP0416225
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N-[(4-tert-butylphenyl)methyl]-2-(3-chloro-4-hydroxyphenyl)propanamide
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C20H24ClNO2
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1
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| 1 |
Ki = 33.1 nM
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CP0452138
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(2S)-N-[3-(3,4-dimethylphenyl)propyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
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C21H27FN2O3S
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2
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| 1 |
Ki = 33.7 nM
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| 2 |
Ki = 257 nM
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CP0432352
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[4-(3,4-dimethylphenyl)-2-[[4-(methanesulfonamido)phenyl]methylcarbamothioylamino]butyl] 2,2-dimethylpropanoate
Show/Hide
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C26H37N3O4S2
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2
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| 1 |
Ki = 33.7 nM
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| 2 |
Ki = 390 nM
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CP0479132
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2-(4-tert-Butylbenzyl)-3-[2-(4-acetoxy-2-bromo-5-methoxyphenyl)acetamido]propyl pivalate
Show/Hide
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C30H40BrNO6
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1
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| 1 |
Ki = 34.9 nM
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CP0441322
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N-(3,3-diphenylpropyl)-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
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C25H27FN2O3S
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2
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| 1 |
Ki = 36.6 nM
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| 2 |
Ki = 130 nM
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CP0458512
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1-(2-chloro-4-hydroxy-5-methoxybenzyl)-3-(4-tert-butylbenzyl)thiourea
Show/Hide
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C20H25ClN2O2S
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1
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| 1 |
Ki = 36.9 nM
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CP0377414
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3-[(4-tert-butylphenyl)methyl]-1-[(1R)-1-(3-fluoro-4-methanesulfonamidophenyl)ethyl]thiourea
Show/Hide
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C21H28FN3O2S2
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2
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| 1 |
Ki = 37 nM
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| 2 |
Ki = 39.2 nM
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CP0469644
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2-(4-tert-Butylbenzyl)-3-[2-(2-chloro-4-hydroxy-5-methoxyphenyl)acetamido]propyl pivalate
Show/Hide
|
C28H38ClNO5
|
1
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| 1 |
Ki = 37.6 nM
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CP0467246
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2-[(3,4-dimethylphenyl)methyl]-3-[2-(4-methanesulfonamidophenyl)propanamido]propyl 2,2-dimethylpropanoate
Show/Hide
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C27H38N2O5S
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2
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| 1 |
Ki = 38 nM
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| 2 |
Ki = 119 nM
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CP0382135
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2-(3-(3-bromo-4-hydroxy-5-methoxybenzyl)thioureido)-3-(4-tert-butylphenyl)propyl pivalate
Show/Hide
|
C27H37BrN2O4S
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1
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| 1 |
Ki = 38.2 nM
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CP0501272
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2-(3-(4-hydroxy-3-iodo-5-methoxybenzyl)thioureido)-3-(4-tert-butylphenyl)propyl pivalate
Show/Hide
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C27H37IN2O4S
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2
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| 1 |
Ki = 39.4 nM
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| 2 |
Ki = 178 nM
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CP0441320
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N-[(4-tert-butyl-2-cyanophenyl)methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
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C22H26FN3O3S
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2
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| 1 |
Ki = 40 nM
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| 2 |
Ki = 44 nM
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CP0464790
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2-(3-(2-chloro-4-hydroxy-5-methoxybenzyl)thioureido)-3-(4-tert-butylphenyl)propyl pivalate
Show/Hide
|
C27H37ClN2O4S
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1
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| 1 |
Ki = 41.5 nM
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CP0425796
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2-(4-tert-Butylbenzyl)-3-[2-(2-bromo-4-methanesulfonylamino-5-methoxyphenyl)acetamido]-propyl pivalate
Show/Hide
|
C29H41BrN2O6S
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1
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| 1 |
Ki = 42.9 nM
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CP0427614
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N-[2-(4-tert-butylphenyl)ethyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
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C22H29FN2O3S
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2
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| 1 |
Ki = 43 nM
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| 2 |
Ki = 554 nM
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CP0441344
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N-[(4-cyclohexylphenyl)methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
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C23H29FN2O3S
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2
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| 1 |
Ki = 43 nM
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| 2 |
Ki = 138 nM
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CP0061655
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[(2R)-2-benzyl-3-[[(1R)-1-[4-(methanesulfonamido)phenyl]ethyl]carbamothioylamino]propyl] 2,2-dimethylpropanoate
Show/Hide
|
C25H35N3O4S2
|
1
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| 1 |
Ki = 44.5 nM
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CP0372035
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2-((3-(4-hydroxy-3-iodo-5-methoxybenzyl)thioureido)methyl)-3-(4-tert-butylphenyl)propyl pivalate
Show/Hide
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C28H39IN2O4S
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2
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| 1 |
Ki = 45 nM
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| 2 |
Ki = 103 nM
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CP0404632
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1-[(4-tert-butylphenyl)methyl]-3-[[2-chloro-4-(methanesulfonamido)phenyl]methyl]thiourea
Show/Hide
|
C20H26ClN3O2S2
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2
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| 1 |
Ki = 45.5 nM
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| 2 |
Ki = 144 nM
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CP0441313
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2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[2-(N-phenylanilino)ethyl]propanamide
Show/Hide
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C24H26FN3O3S
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2
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| 1 |
Ki = 47 nM
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| 2 |
Ki = 115 nM
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CP0479124
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[4-[2-[(4-tert-butylphenyl)methylamino]-2-oxoethyl]-2-iodo-6-methoxyphenyl] acetate
Show/Hide
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C22H26INO4
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2
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| 1 |
Ki = 47.9 nM
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| 2 |
Ki = 94 nM
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CP0525951
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1-(3-bromo-4-hydroxy-5-methoxybenzyl)-3-(4-tert-butylbenzyl)thiourea
Show/Hide
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C20H25BrN2O2S
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2
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| 1 |
Ki = 49 nM
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| 2 |
Ki = 51.6 nM
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CP0493319
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2-[(4-tert-butylphenyl)methyl]-3-[2-(4-methanesulfonamidophenyl)propanamido]propyl 2,2-dimethylpropanoate
Show/Hide
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C29H42N2O5S
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2
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| 1 |
Ki = 52 nM
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| 2 |
Ki = 55 nM
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CP0302906
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[(2R)-2-[(4-tert-butylphenyl)methyl]-3-[[(1R)-1-[4-(methanesulfonamido)phenyl]ethyl]carbamothioylamino]propyl] 2,2-dimethylpropanoate
Show/Hide
|
C29H43N3O4S2
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1
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| 1 |
Ki = 53 nM
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CP0410302
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3-[(4-tert-butylphenyl)methyl]-1-[(4-methanesulfonamidophenyl)methyl]thiourea
Show/Hide
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C20H27N3O2S2
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3
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| 1 |
Ki = 53.9 nM
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| 2 |
Ki = 54 nM
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| 3 |
Ki = 63 nM
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CP0526702
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3-[(4-tert-butylphenyl)methyl]-1-[1-(3-fluoro-4-methanesulfonamidophenyl)propyl]thiourea
Show/Hide
|
C22H30FN3O2S2
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2
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| 1 |
Ki = 54 nM
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| 2 |
Ki = 230 nM
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CP0452140
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N-[(4-cyclopropylphenyl)methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
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C20H23FN2O3S
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2
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| 1 |
Ki = 55.5 nM
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| 2 |
Ki = 411 nM
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CP0479131
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3-[2-(3-Bromo-4-hydroxy-5-methoxyphenyl)acetamido]-2-(3,4-dimethylbenzyl)propyl pivalate
Show/Hide
|
C26H34BrNO5
|
1
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| 1 |
Ki = 56.4 nM
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CP0425819
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2-(4-tert-Butylbenzyl)-3-[2-(4-amino-3-bromophenyl)acetamido]propyl pivalate
Show/Hide
|
C27H37BrN2O3
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1
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| 1 |
Ki = 57 nM
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CP0526703
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1-[(4-tert-butylphenyl)methyl]-3-[1-(4-methanesulfonamidophenyl)cyclopropyl]thiourea
Show/Hide
|
C22H29N3O2S2
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2
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| 1 |
Ki = 60 nM
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| 2 |
Ki = 171 nM
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CP0477916
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(2S)-2-[(4-tert-butylphenyl)methyl]-3-[(2R)-2-(3-fluoro-4-methanesulfonamidophenyl)propanamido]propyl 2,2-dimethylpropanoate
Show/Hide
|
C29H41FN2O5S
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2
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| 1 |
Ki = 64 nM
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| 2 |
Ki = 142 nM
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CP0363530
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2,2-Dimethyl-propionic acid 2-(4-tert-butyl-benzyl)-3-[3-(4-methanesulfonylamino-benzyl)-thioureido]-propyl ester
Show/Hide
|
C28H41N3O4S2
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2
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| 1 |
Ki = 64 nM
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| 2 |
Ki = 86 nM
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CP0248038
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[(2R)-2-benzyl-3-[[4-(methanesulfonamido)phenyl]methylcarbamothioylamino]propyl] 2,2-dimethylpropanoate
Show/Hide
|
C24H33N3O4S2
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1
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| 1 |
Ki = 64.3 nM
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CP0378460
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2-[(3,4-dimethylphenyl)methyl]-3-[2-(3-fluoro-4-methanesulfonamidophenyl)-2-methylpropanamido]propyl 2,2-dimethylpropanoate
Show/Hide
|
C28H39FN2O5S
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2
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| 1 |
Ki = 65 nM
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| 2 |
Ki = 280 nM
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CP0302904
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[(2R)-2-[(3,4-dimethylphenyl)methyl]-3-[[4-(methanesulfonamido)phenyl]methylcarbamothioylamino]propyl] 2,2-dimethylpropanoate
Show/Hide
|
C26H37N3O4S2
|
1
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| 1 |
Ki = 67 nM
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CP0399731
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2-(3-(4-hydroxy-2-iodo-5-methoxybenzyl)thioureido)-4-(4-tert-butylphenyl)butyl pivalate
Show/Hide
|
C28H39IN2O4S
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2
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| 1 |
Ki = 69 nM
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| 2 |
Ki = 79 nM
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CP0444273
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[2-(4-tert-butylphenyl)-3-[[3-fluoro-4-(methanesulfonamido)phenyl]methylcarbamothioylamino]propyl] 2,2-dimethylpropanoate
Show/Hide
|
C27H38FN3O4S2
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2
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| 1 |
Ki = 69 nM
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| 2 |
Ki = 116 nM
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CP0382141
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2-(3-(2-chloro-4-hydroxy-5-methoxybenzyl)thioureido)-4-(4-tert-butylphenyl)butyl pivalate
Show/Hide
|
C28H39ClN2O4S
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2
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| 1 |
Ki = 72.2 nM
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| 2 |
Ki = 79 nM
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CP0372037
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2-(3-(2-bromo-4-hydroxy-5-methoxybenzyl)thioureido)-3-(4-tert-butylphenyl)propyl pivalate
Show/Hide
|
C27H37BrN2O4S
|
1
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| 1 |
Ki = 74.9 nM
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CP0511427
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2-(3-(2-bromo-4-hydroxy-5-methoxybenzyl)thioureido)-4-(4-tert-butylphenyl)butyl pivalate
Show/Hide
|
C28H39BrN2O4S
|
2
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| 1 |
Ki = 75 nM
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| 2 |
Ki = 76.1 nM
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CP0399734
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1-(3-chloro-4-hydroxy-5-methoxybenzyl)-3-(4-tert-butylbenzyl)thiourea
Show/Hide
|
C20H25ClN2O2S
|
1
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| 1 |
Ki = 76 nM
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CP0396409
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[(2S)-2-benzyl-3-[[4-(methanesulfonamido)phenyl]methylcarbamothioylamino]propyl] 2,2-dimethylpropanoate
Show/Hide
|
C24H33N3O4S2
|
1
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| 1 |
Ki = 80.6 nM
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CP0398039
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2-(4-tert-Butylbenzyl)-3-[2-(4-methanesulfonylamino-3-ethoxyphenyl)acetamido]propyl pivalate
Show/Hide
|
C29H42N2O6S
|
1
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| 1 |
Ki = 84.5 nM
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CP0372036
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2-(3-(3-chloro-4-hydroxy-5-methoxybenzyl)thioureido)-4-(3,4-dimethylphenyl)butyl pivalate
Show/Hide
|
C26H35ClN2O4S
|
1
|
| 1 |
Ki = 86 nM
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|
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CP0282395
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[(2R)-2-[(4-tert-butylphenyl)methyl]-3-[[4-(methanesulfonamido)phenyl]methylcarbamothioylamino]propyl] 2,2-dimethylpropanoate
Show/Hide
|
C28H41N3O4S2
|
1
|
| 1 |
Ki = 86 nM
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|
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CP0168119
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[(2S)-2-benzyl-3-[[(1R)-1-[4-(methanesulfonamido)phenyl]ethyl]carbamothioylamino]propyl] 2,2-dimethylpropanoate
Show/Hide
|
C25H35N3O4S2
|
1
|
| 1 |
Ki = 89 nM
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|
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CP0425792
|
2-(3-bromo-4-hydroxy-5-methoxyphenyl)-N-[(4-tert-butylphenyl)methyl]acetamide
Show/Hide
|
C20H24BrNO3
|
2
|
| 1 |
Ki = 91 nM
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| 2 |
Ki = 168 nM
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CP0420918
|
[2-(4-tert-butylphenyl)-3-[[4-(methanesulfonamido)phenyl]methylcarbamothioylamino]propyl] 2,2-dimethylpropanoate
Show/Hide
|
C27H39N3O4S2
|
2
|
| 1 |
Ki = 91 nM
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| 2 |
Ki = 143 nM
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CP0493356
|
2-(3-(4-hydroxy-2-iodo-5-methoxybenzyl)thioureido)-3-(4-tert-butylphenyl)propyl pivalate
Show/Hide
|
C27H37IN2O4S
|
2
|
| 1 |
Ki = 96 nM
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| 2 |
Ki = 310 nM
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CP0888447
|
rac-N-[3-(3,4-Dimethylphenyl)propyl]-2-[3-fluoro-4-(methylsulfonylamino)phenyl]propionamide
Show/Hide
|
C21H27FN2O3S
|
2
|
| 1 |
Ki = 97 nM
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| 2 |
Ki = 413 nM
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|
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CP0378463
|
(2R)-2-benzyl-3-[(2R)-2-(3-fluoro-4-methanesulfonamidophenyl)propanamido]propyl 2,2-dimethylpropanoate
Show/Hide
|
C25H33FN2O5S
|
2
|
| 1 |
Ki = 98 nM
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|
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| 2 |
Ki = 298 nM
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|
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CP0437365
|
3-[(4-tert-butylphenyl)methyl]-1-[(3-fluoro-4-methanesulfonamidophenyl)(phenyl)methyl]thiourea
Show/Hide
|
C26H30FN3O2S2
|
2
|
| 1 |
Ki = 100 nM
|
|
|
| 2 |
Ki = 860 nM
|
|
|
|
CP0553056
|
2-(3-(3-bromo-4-hydroxy-5-methoxybenzyl)thioureido)-4-(3,4-dimethylphenyl)butyl pivalate
Show/Hide
|
C26H35BrN2O4S
|
1
|
| 1 |
Ki = 102 nM
|
|
|
|
CP0378366
|
2-(3-(2-chloro-4-hydroxy-5-methoxybenzyl)thioureido)-4-(3,4-dimethylphenyl)butyl pivalate
Show/Hide
|
C26H35ClN2O4S
|
1
|
| 1 |
Ki = 103 nM
|
|
|
|
CP0372357
|
2-[(3,4-dimethylphenyl)methyl]-3-[2-(4-methanesulfonamidophenyl)-2-methylpropanamido]propyl 2,2-dimethylpropanoate
Show/Hide
|
C28H40N2O5S
|
2
|
| 1 |
Ki = 104 nM
|
|
|
| 2 |
Ki = 370 nM
|
|
|
|
CP0427617
|
3-(4-tert-butylphenyl)-N-[1-[3-fluoro-4-(methanesulfonamido)phenyl]ethyl]propanamide
Show/Hide
|
C22H29FN2O3S
|
2
|
| 1 |
Ki = 104 nM
|
|
|
| 2 |
Ki = 380 nM
|
|
|
|
CP0388742
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[(4-iodophenyl)methyl]propanamide
Show/Hide
|
C17H18FIN2O3S
|
2
|
| 1 |
Ki = 107 nM
|
|
|
| 2 |
Ki = 502 nM
|
|
|
|
CP0479129
|
2-(4-tert-Butylbenzyl)-3-[2-(3,5-dibromophenyl)acetamido]propyl pivalate
Show/Hide
|
C27H35Br2NO3
|
2
|
| 1 |
Ki = 108 nM
|
|
|
| 2 |
Ki = 210 nM
|
|
|
|
CP0434116
|
2-(3-(2-bromo-4-hydroxy-5-methoxybenzyl)thioureido)-4-(3,4-dimethylphenyl)butyl pivalate
Show/Hide
|
C26H35BrN2O4S
|
1
|
| 1 |
Ki = 109 nM
|
|
|
|
CP0440091
|
(4-tert-Butyl-benzyl)-thiocarbamic acid 4-methanesulfonylamino-3-methoxy-benzyl ester
Show/Hide
|
C21H28N2O4S2
|
2
|
| 1 |
Ki = 110 nM
|
|
|
| 2 |
Ki = 461 nM
|
|
|
|
CP0444272
|
[4-(3,4-dimethylphenyl)-2-[[3-fluoro-4-(methanesulfonamido)phenyl]methylcarbamothioylamino]butyl] 2,2-dimethylpropanoate
Show/Hide
|
C26H36FN3O4S2
|
2
|
| 1 |
Ki = 111 nM
|
|
|
| 2 |
Ki = 120 nM
|
|
|
|
CP0434044
|
2-(3-(4-hydroxy-3-iodo-5-methoxybenzyl)thioureido)-4-(3,4-dimethylphenyl)butyl pivalate
Show/Hide
|
C26H35IN2O4S
|
2
|
| 1 |
Ki = 115 nM
|
|
|
| 2 |
Ki = 127 nM
|
|
|
|
CP0441311
|
N-[(3,4-dichlorophenyl)methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C17H17Cl2FN2O3S
|
2
|
| 1 |
Ki = 115 nM
|
|
|
| 2 |
Ki = 200 nM
|
|
|
|
CP0416589
|
[3-(4-tert-butylphenyl)-2-[[3-fluoro-4-(methanesulfonamido)phenyl]methylcarbamothioylamino]propyl] 2,2-dimethylpropanoate
Show/Hide
|
C27H38FN3O4S2
|
2
|
| 1 |
Ki = 115 nM
|
|
|
| 2 |
Ki = 179 nM
|
|
|
|
CP0479100
|
2-(3,4-Dimethylbenzyl)-3-[2-(4-hydroxy-2-iodo-5-methoxyphenyl)acetamido]propyl pivalate
Show/Hide
|
C26H34INO5
|
1
|
| 1 |
Ki = 116 nM
|
|
|
|
CP0427616
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[2-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,9,11,13-heptaenylidene)ethyl]propanamide
Show/Hide
|
C27H25FN2O3S
|
2
|
| 1 |
Ki = 117 nM
|
|
|
| 2 |
Ki = 163 nM
|
|
|
|
CP0467244
|
2-[(3,4-dimethylphenyl)methyl]-3-{[1-(4-methanesulfonamido-3-methoxyphenyl)cyclopropyl]formamido}propyl 2,2-dimethylpropanoate
Show/Hide
|
C29H40N2O6S
|
2
|
| 1 |
Ki = 118 nM
|
|
|
| 2 |
Ki = 239 nM
|
|
|
|
CP0475858
|
N-[(4-tert-butylphenyl)methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]acetamide
Show/Hide
|
C20H25FN2O3S
|
3
|
| 1 |
Ki = 118 nM
|
|
|
| 2 |
Ki = 470 nM
|
|
|
| 3 |
Ki = 472 nM
|
|
|
|
CP0391646
|
1-[(4-tert-butylphenyl)methyl]-3-[[4-(methanesulfonamido)-2-(trifluoromethyl)phenyl]methyl]thiourea
Show/Hide
|
C21H26F3N3O2S2
|
2
|
| 1 |
Ki = 119 nM
|
|
|
| 2 |
Ki = 440 nM
|
|
|
|
CP0485835
|
(4-tert-Butyl-benzyl)-thiocarbamic acid 3-fluoro-4-methanesulfonylamino-benzyl ester
Show/Hide
|
C20H25FN2O3S2
|
2
|
| 1 |
Ki = 120 nM
|
|
|
| 2 |
Ki = 450 nM
|
|
|
|
CP0494056
|
N-[(4-tert-butylphenyl)methyl]-2-[2-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C21H27FN2O3S
|
2
|
| 1 |
Ki = 120 nM
|
|
|
| 2 |
Ki = 360 nM
|
|
|
|
CP0378352
|
2-((3-(4-hydroxy-3-iodo-5-methoxybenzyl)thioureido)methyl)-3-(3,4-dimethylphenyl)propyl pivalate
Show/Hide
|
C26H35IN2O4S
|
2
|
| 1 |
Ki = 121 nM
|
|
|
| 2 |
Ki = 232 nM
|
|
|
|
CP0372288
|
2-(3-(3-chloro-4-hydroxy-5-methoxybenzyl)thioureido)-4-(4-tert-butylphenyl)butyl pivalate
Show/Hide
|
C28H39ClN2O4S
|
1
|
| 1 |
Ki = 122 nM
|
|
|
|
CP0437978
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[2-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenylidene)ethyl]propanamide
Show/Hide
|
C27H27FN2O3S
|
2
|
| 1 |
Ki = 122 nM
|
|
|
| 2 |
Ki = 141 nM
|
|
|
|
CP0049381
|
N-[(4-hydroxy-2-iodo-5-methoxyphenyl)methyl]nonanamide
Show/Hide
|
C17H26INO3
|
2
|
| 1 |
Ki = 127 nM
|
|
|
| 2 |
Ki = 1320 nM
|
|
|
|
CP0427619
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[(4-propan-2-ylphenyl)methyl]propanamide
Show/Hide
|
C20H25FN2O3S
|
2
|
| 1 |
Ki = 127 nM
|
|
|
| 2 |
Ki = 144 nM
|
|
|
|
CP0372285
|
1-(4-tert-butylbenzyl)-3-(4-hydroxy-2-iodo-5-methoxybenzyl)thiourea
Show/Hide
|
C20H25IN2O2S
|
2
|
| 1 |
Ki = 130 nM
|
|
|
| 2 |
Ki = 156 nM
|
|
|
|
CP0467245
|
2-[(3,4-dimethylphenyl)methyl]-3-[2-(4-methanesulfonamido-3-methoxyphenyl)-2-methylpropanamido]propyl 2,2-dimethylpropanoate
Show/Hide
|
C29H42N2O6S
|
2
|
| 1 |
Ki = 133 nM
|
|
|
| 2 |
Ki = 153 nM
|
|
|
|
CP0061656
|
[(2S)-2-benzyl-3-[[(1S)-1-[4-(methanesulfonamido)phenyl]ethyl]carbamothioylamino]propyl] 2,2-dimethylpropanoate
Show/Hide
|
C25H35N3O4S2
|
1
|
| 1 |
Ki = 133 nM
|
|
|
|
CP0441321
|
N-[3-(4-chlorophenyl)propyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C19H22ClFN2O3S
|
2
|
| 1 |
Ki = 135 nM
|
|
|
| 2 |
Ki = 470 nM
|
|
|
|
CP0382140
|
2-(3-(4-hydroxy-2-iodo-5-methoxybenzyl)thioureido)-4-(3,4-dimethylphenyl)butyl pivalate
Show/Hide
|
C26H35IN2O4S
|
2
|
| 1 |
Ki = 140 nM
|
|
|
| 2 |
Ki = 176 nM
|
|
|
|
CP0495751
|
2-(3-(3-bromo-4-hydroxy-5-methoxybenzyl)thioureido)-4-(4-tert-butylphenyl)butyl pivalate
Show/Hide
|
C28H39BrN2O4S
|
1
|
| 1 |
Ki = 143 nM
|
|
|
|
CP0464665
|
2-Azido-ethanesulfonic acid {4-[3-(4-tert-butyl-benzyl)-thioureidomethyl]-phenyl}-amide
Show/Hide
|
C21H28N6O2S2
|
2
|
| 1 |
Ki = 145 nM
|
|
|
| 2 |
Ki = 231 nM
|
|
|
|
CP0478386
|
N-[(2,2-diphenylcyclopropyl)methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C26H27FN2O3S
|
2
|
| 1 |
Ki = 148 nM
|
|
|
| 2 |
Ki = 188 nM
|
|
|
|
CP0416590
|
[4-(4-tert-butylphenyl)-2-[[3-fluoro-4-(methanesulfonamido)phenyl]methylcarbamothioylamino]butyl] 2,2-dimethylpropanoate
Show/Hide
|
C28H40FN3O4S2
|
2
|
| 1 |
Ki = 152 nM
|
|
|
| 2 |
Ki = 190 nM
|
|
|
|
CP0484771
|
N-[(E)-3-(3,4-dimethylphenyl)prop-2-enyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C21H25FN2O3S
|
2
|
| 1 |
Ki = 153 nM
|
|
|
| 2 |
Ki = 277 nM
|
|
|
|
CP0502845
|
N-[(4-tert-butylphenyl)methyl]-2-(3-chloro-4-hydroxy-5-methoxyphenyl)acetamide
Show/Hide
|
C20H24ClNO3
|
1
|
| 1 |
Ki = 164 nM
|
|
|
|
CP0493490
|
[2-bromo-4-[2-[(4-tert-butylphenyl)methylamino]-2-oxoethyl]-6-methoxyphenyl] acetate
Show/Hide
|
C22H26BrNO4
|
1
|
| 1 |
Ki = 166 nM
|
|
|
|
CP0495747
|
1-(4-tert-butylbenzyl)-3-(4-hydroxy-3-iodo-5-methoxybenzyl)thiourea
Show/Hide
|
C20H25IN2O2S
|
2
|
| 1 |
Ki = 176 nM
|
|
|
| 2 |
Ki = 342 nM
|
|
|
|
CP0464667
|
1-[(4-tert-butylphenyl)methyl]-3-[[6-(methanesulfonamido)pyridin-3-yl]methyl]thiourea
Show/Hide
|
C19H26N4O2S2
|
2
|
| 1 |
Ki = 177 nM
|
|
|
| 2 |
Ki = 4100 nM
|
|
|
|
CP0426680
|
(2R)-N-[(4-tert-butylphenyl)methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C21H27FN2O3S
|
2
|
| 1 |
Ki = 186 nM
|
|
|
| 2 |
Ki = 750 nM
|
|
|
|
CP0508053
|
[(2R)-2-[[(1R)-1-[4-(methanesulfonamido)phenyl]ethyl]carbamothioylamino]-3-phenylpropyl] 2,2-dimethylpropanoate
Show/Hide
|
C24H33N3O4S2
|
1
|
| 1 |
Ki = 193 nM
|
|
|
|
CP0372355
|
2-[(3,4-dimethylphenyl)methyl]-3-{[1-(4-methanesulfonamidophenyl)cyclopropyl]formamido}propyl 2,2-dimethylpropanoate
Show/Hide
|
C28H38N2O5S
|
2
|
| 1 |
Ki = 197 nM
|
|
|
| 2 |
Ki = 396 nM
|
|
|
|
CP0410285
|
[2-(4-tert-butylphenyl)-2-[[4-(methanesulfonamido)phenyl]methylcarbamothioylamino]ethyl] 2,2-dimethylpropanoate
Show/Hide
|
C26H37N3O4S2
|
2
|
| 1 |
Ki = 197 nM
|
|
|
| 2 |
Ki = 940 nM
|
|
|
|
CP0441312
|
(2R)-N-[3-(3,4-dimethylphenyl)propyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C21H27FN2O3S
|
2
|
| 1 |
Ki = 204 nM
|
|
|
| 2 |
Ki = 950 nM
|
|
|
|
CP0464921
|
(2S)-2-benzyl-3-[(2R)-2-(3-fluoro-4-methanesulfonamidophenyl)propanamido]propyl 2,2-dimethylpropanoate
Show/Hide
|
C25H33FN2O5S
|
2
|
| 1 |
Ki = 205 nM
|
|
|
| 2 |
Ki = 370 nM
|
|
|
|
CP0505465
|
[4-[2-[(4-tert-butylphenyl)methylamino]-2-oxoethyl]-2-chloro-6-methoxyphenyl] acetate
Show/Hide
|
C22H26ClNO4
|
2
|
| 1 |
Ki = 205 nM
|
|
|
| 2 |
Ki = 570 nM
|
|
|
|
CP0416588
|
[2-(4-tert-butylphenyl)-2-[[3-fluoro-4-(methanesulfonamido)phenyl]methylcarbamothioylamino]ethyl] 2,2-dimethylpropanoate
Show/Hide
|
C26H36FN3O4S2
|
2
|
| 1 |
Ki = 213 nM
|
|
|
| 2 |
Ki = 244 nM
|
|
|
|
CP0382136
|
2-(3-(4-hydroxy-3-iodo-5-methoxybenzyl)thioureido)-4-(4-tert-butylphenyl)butyl pivalate
Show/Hide
|
C28H39IN2O4S
|
2
|
| 1 |
Ki = 214 nM
|
|
|
| 2 |
Ki = 525 nM
|
|
|
|
CP0485834
|
(4-tert-Butyl-benzyl)-thiocarbamic acid 4-methanesulfonylamino-benzyl ester
Show/Hide
|
C20H26N2O3S2
|
2
|
| 1 |
Ki = 222 nM
|
|
|
| 2 |
Ki = 772 nM
|
|
|
|
CP0433964
|
3-[(4-tert-butylphenyl)methyl]-1-[1-(3-fluoro-4-methanesulfonamidophenyl)-2-methylpropyl]thiourea
Show/Hide
|
C23H32FN3O2S2
|
2
|
| 1 |
Ki = 223 nM
|
|
|
| 2 |
Ki = 339 nM
|
|
|
|
CP0398875
|
1-[(4-tert-butylphenyl)methyl]-3-[[4-(methanesulfonamido)phenyl]methyl]urea
Show/Hide
|
C20H27N3O3S
|
2
|
| 1 |
Ki = 225 nM
|
|
|
| 2 |
Ki = 2560 nM
|
|
|
|
CP0425817
|
3-[2-(4-Hydroxy-3-iodo-5-methoxyphenyl)acetamido]-2-(3,4-dimethylbenzyl)propyl pivalate
Show/Hide
|
C26H34INO5
|
2
|
| 1 |
Ki = 225 nM
|
|
|
| 2 |
Ki = 1630 nM
|
|
|
|
CP0437720
|
N-[(4-tert-butylphenyl)methyl]-2-[4-(methanesulfonamido)-3-methoxyphenyl]propanamide
Show/Hide
|
C22H30N2O4S
|
2
|
| 1 |
Ki = 232 nM
|
|
|
| 2 |
Ki = 540 nM
|
|
|
|
CP0416587
|
[3-(3,4-dimethylphenyl)-2-[[3-fluoro-4-(methanesulfonamido)phenyl]methylcarbamothioylamino]propyl] 2,2-dimethylpropanoate
Show/Hide
|
C25H34FN3O4S2
|
2
|
| 1 |
Ki = 233 nM
|
|
|
| 2 |
Ki = 650 nM
|
|
|
|
CP0484770
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-(naphthalen-2-ylmethyl)propanamide
Show/Hide
|
C21H21FN2O3S
|
2
|
| 1 |
Ki = 240 nM
|
|
|
| 2 |
Ki = 960 nM
|
|
|
|
CP0377409
|
1-[(4-tert-butylphenyl)methyl]-3-[1-(4-methanesulfonamido-3-methoxyphenyl)cyclopropyl]thiourea
Show/Hide
|
C23H31N3O3S2
|
2
|
| 1 |
Ki = 243 nM
|
|
|
| 2 |
Ki = 370 nM
|
|
|
|
CP0437979
|
N-[(4-bromophenyl)methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C17H18BrFN2O3S
|
2
|
| 1 |
Ki = 250 nM
|
|
|
| 2 |
Ki = 412 nM
|
|
|
|
CP0393084
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[(4-phenylphenyl)methyl]propanamide
Show/Hide
|
C23H23FN2O3S
|
2
|
| 1 |
Ki = 261 nM
|
|
|
| 2 |
Ki = 1750 nM
|
|
|
|
CP0441318
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[[4-(trifluoromethyl)phenyl]methyl]propanamide
Show/Hide
|
C18H18F4N2O3S
|
2
|
| 1 |
Ki = 274 nM
|
|
|
| 2 |
Ki = 660 nM
|
|
|
|
CP0420919
|
[4-(4-tert-butylphenyl)-2-[[4-(methanesulfonamido)phenyl]methylcarbamothioylamino]butyl] 2,2-dimethylpropanoate
Show/Hide
|
C28H41N3O4S2
|
2
|
| 1 |
Ki = 286 nM
|
|
|
| 2 |
Ki = 366 nM
|
|
|
|
CP0556639
|
[(2S)-2-[[(1R)-1-[4-(methanesulfonamido)phenyl]ethyl]carbamothioylamino]-3-phenylpropyl] 2,2-dimethylpropanoate
Show/Hide
|
C24H33N3O4S2
|
1
|
| 1 |
Ki = 290 nM
|
|
|
|
CP0147525
|
2,2-Dimethyl-propionic acid 2-(3,4-dimethyl-benzyl)-3-[3-(4-ethanesulfonylamino-benzyl)-thioureido]-propyl ester
Show/Hide
|
C27H39N3O4S2
|
1
|
| 1 |
Ki = 309 nM
|
|
|
|
CP0410305
|
N-[(4-tert-butylphenyl)methyl]-2-[3-cyano-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C22H27N3O3S
|
2
|
| 1 |
Ki = 344 nM
|
|
|
| 2 |
Ki = 467 nM
|
|
|
|
CP0425795
|
2-(2-bromo-4-hydroxy-5-methoxyphenyl)-N-[(4-tert-butylphenyl)methyl]acetamide
Show/Hide
|
C20H24BrNO3
|
1
|
| 1 |
Ki = 364 nM
|
|
|
|
CP0427618
|
N-[(4-chlorophenyl)methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C17H18ClFN2O3S
|
2
|
| 1 |
Ki = 367 nM
|
|
|
| 2 |
Ki = 1060 nM
|
|
|
|
CP0479126
|
[4-[2-[(4-tert-butylphenyl)methylamino]-2-oxoethyl]-5-iodo-2-methoxyphenyl] acetate
Show/Hide
|
C22H26INO4
|
1
|
| 1 |
Ki = 378 nM
|
|
|
|
CP0416227
|
2-[4-(2-aminoethoxy)-3-chlorophenyl]-N-[(4-tert-butylphenyl)methyl]propanamide
Show/Hide
|
C22H29ClN2O2
|
1
|
| 1 |
Ki = 380 nM
|
|
|
|
CP0388739
|
N-[(E)-3-(4-chlorophenyl)prop-2-enyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C19H20ClFN2O3S
|
2
|
| 1 |
Ki = 384 nM
|
|
|
| 2 |
Ki = 897 nM
|
|
|
|
CP0502844
|
[4-[2-[(4-tert-butylphenyl)methylamino]-2-oxoethyl]-5-chloro-2-methoxyphenyl] acetate
Show/Hide
|
C22H26ClNO4
|
1
|
| 1 |
Ki = 388 nM
|
|
|
|
CP0398034
|
[5-bromo-4-[2-[(4-tert-butylphenyl)methylamino]-2-oxoethyl]-2-methoxyphenyl] acetate
Show/Hide
|
C22H26BrNO4
|
1
|
| 1 |
Ki = 393 nM
|
|
|
|
CP0451880
|
N-[(4-tert-butylphenyl)methyl]-2-[4-(methanesulfonamido)phenyl]acetamide
Show/Hide
|
C20H26N2O3S
|
2
|
| 1 |
Ki = 398 nM
|
|
|
| 2 |
Ki = 2100 nM
|
|
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CP0436639
|
1-[(4-tert-butylphenyl)methyl]-3-[[3-chloro-4-(methanesulfonamido)phenyl]methyl]thiourea
Show/Hide
|
C20H26ClN3O2S2
|
2
|
| 1 |
Ki = 400 nM
|
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| 2 |
Ki = 1160 nM
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CP0441317
|
N-[(4-tert-butylphenyl)methyl]-2-[4-(methanesulfonamido)-3-methoxyphenyl]-2-methylpropanamide
Show/Hide
|
C23H32N2O4S
|
2
|
| 1 |
Ki = 414 nM
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| 2 |
Ki = 707 nM
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CP0432349
|
[3-(4-tert-butylphenyl)-2-[[4-(methanesulfonamido)phenyl]methylcarbamothioylamino]propyl] 2,2-dimethylpropanoate
Show/Hide
|
C27H39N3O4S2
|
1
|
| 1 |
Ki = 416 nM
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CP0388738
|
N-[(4-tert-butylphenyl)methyl]-2-[4-(methanesulfonamido)phenyl]-2-methylpropanamide
Show/Hide
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C22H30N2O3S
|
2
|
| 1 |
Ki = 430 nM
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| 2 |
Ki = 2550 nM
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CP0441316
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N-[(4-tert-butylphenyl)methyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]-2-methylpropanamide
Show/Hide
|
C22H29FN2O3S
|
2
|
| 1 |
Ki = 467 nM
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| 2 |
Ki = 1070 nM
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CP0398870
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1-[(4-tert-butylphenyl)methyl]-1-hydroxy-3-[[4-(methanesulfonamido)phenyl]methyl]thiourea
Show/Hide
|
C20H27N3O3S2
|
2
|
| 1 |
Ki = 470 nM
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| 2 |
Ki = 1090 nM
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CP0431267
|
3-[(4-tert-butylphenyl)methyl]-1-hydroxy-1-[[4-(methanesulfonamido)phenyl]methyl]thiourea
Show/Hide
|
C20H27N3O3S2
|
2
|
| 1 |
Ki = 470 nM
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| 2 |
Ki = 4260 nM
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CP0050997
|
N-[2-(4-chlorophenyl)ethyl]-7,8-dihydroxy-1,3,4,5-tetrahydro-2-benzazepine-2-carbothioamide
Show/Hide
|
C19H21ClN2O2S
|
2
|
| 1 |
Ki = 520 nM
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| 2 |
Ki = 1300 nM
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CP0033479
|
(chloropromazine) [3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine
Show/Hide
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C17H19ClN2S
|
2
|
| 1 |
Ki = 520 nM
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| 2 |
Ki = 1300 nM
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CP0404043
|
2,2-Dimethyl-propionic acid 2-(3,4-dimethyl-benzyl)-3-[3-(3-fluoro-4-methanesulfonylamino-benzyl)-thioureido-N-hydroxy]-propyl ester
Show/Hide
|
C26H36FN3O5S2
|
1
|
| 1 |
Ki = 546 nM
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CP0407830
|
2-[(3,4-dimethylphenyl)methyl]-3-{[1-(3-fluoro-4-methanesulfonamidophenyl)cyclopropyl]formamido}propyl 2,2-dimethylpropanoate
Show/Hide
|
C28H37FN2O5S
|
2
|
| 1 |
Ki = 567 nM
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| 2 |
Ki = 1580 nM
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CP0483623
|
1-[(4-tert-butylphenyl)methyl]-3-[[3-chloro-4-(methanesulfonamido)phenyl]methyl]-1-hydroxythiourea
Show/Hide
|
C20H26ClN3O3S2
|
2
|
| 1 |
Ki = 579 nM
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| 2 |
Ki = 1310 nM
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CP0464661
|
1-(4-tert-Butyl-benzyl)-3-(3-methylsulfanyl-benzyl)-thiourea
Show/Hide
|
C20H26N2S2
|
1
|
| 1 |
Ki = 580 nM
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|
|
CP0385348
|
[3-(3,4-dimethylphenyl)-2-[[4-(methanesulfonamido)phenyl]methylcarbamothioylamino]propyl] 2,2-dimethylpropanoate
Show/Hide
|
C25H35N3O4S2
|
1
|
| 1 |
Ki = 580 nM
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|
|
CP0393425
|
1-[(4-tert-butylphenyl)methyl]-3-[[4-(methanesulfonamido)-3-nitrophenyl]methyl]thiourea
Show/Hide
|
C20H26N4O4S2
|
2
|
| 1 |
Ki = 610 nM
|
|
|
| 2 |
Ki = 1300 nM
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CP0437745
|
N-[(4-tert-butylphenyl)methyl]-1-[4-(methanesulfonamido)phenyl]cyclopropane-1-carboxamide
Show/Hide
|
C22H28N2O3S
|
2
|
| 1 |
Ki = 610 nM
|
|
|
| 2 |
Ki = 1770 nM
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CP0453346
|
2,2-Dimethyl-propionic acid 2-(3,4-dimethyl-benzyl)-3-[3-(2-fluro-4-methanesulfonylamino-benzyl)-thioureido-N-hydroxy]-propyl ester
Show/Hide
|
C26H36FN3O5S2
|
1
|
| 1 |
Ki = 620 nM
|
|
|
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CP0404614
|
1-[(4-tert-butylphenyl)methyl]-1-hydroxy-3-[[4-(methanesulfonamido)-3-nitrophenyl]methyl]thiourea
Show/Hide
|
C20H26N4O5S2
|
2
|
| 1 |
Ki = 635 nM
|
|
|
| 2 |
Ki = 1330 nM
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CP0483602
|
1-[(4-tert-butylphenyl)methyl]-3-[[4-(sulfamoylamino)phenyl]methyl]thiourea
Show/Hide
|
C19H26N4O2S2
|
1
|
| 1 |
Ki = 650 nM
|
|
|
|
CP0474305
|
1-[(4-tert-butylphenyl)methyl]-3-[5-(methanesulfonamido)-2,3-dihydro-1H-inden-1-yl]thiourea
Show/Hide
|
C22H29N3O2S2
|
2
|
| 1 |
Ki = 660 nM
|
|
|
| 2 |
Ki = 740 nM
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CP0464439
|
3-[(4-tert-butylphenyl)methyl]-1-[2-(4-methanesulfonamido-3-methoxyphenyl)propan-2-yl]thiourea
Show/Hide
|
C23H33N3O3S2
|
2
|
| 1 |
Ki = 663 nM
|
|
|
| 2 |
Ki = 2890 nM
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|
|
CP0490105
|
1-[(4-tert-butylphenyl)methyl]-3-[2-[4-(methanesulfonamido)phenyl]ethyl]thiourea
Show/Hide
|
C21H29N3O2S2
|
2
|
| 1 |
Ki = 699 nM
|
|
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| 2 |
Ki = 3900 nM
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CP0377410
|
3-[(4-tert-butylphenyl)methyl]-1-[1-(3-fluoro-4-methanesulfonamidophenyl)-2-phenylethyl]thiourea
Show/Hide
|
C27H32FN3O2S2
|
2
|
| 1 |
Ki = 700 nM
|
|
|
| 2 |
Ki = 1740 nM
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CP0455684
|
1-[(4-tert-butylphenyl)methyl]-3-[[3-hydroxy-4-(methanesulfonamido)phenyl]methyl]thiourea
Show/Hide
|
C20H27N3O3S2
|
1
|
| 1 |
Ki = 750 nM
|
|
|
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CP0388737
|
N-[(4-tert-butylphenyl)methyl]-1-[4-(methanesulfonamido)-3-methoxyphenyl]cyclopropane-1-carboxamide
Show/Hide
|
C23H30N2O4S
|
2
|
| 1 |
Ki = 750 nM
|
|
|
| 2 |
Ki = 2250 nM
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|
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CP0425818
|
2-(4-tert-Butylbenzyl)-3-[2-(4-amino-3-chlorophenyl)acetamido]propyl pivalate
Show/Hide
|
C27H37ClN2O3
|
1
|
| 1 |
Ki = 790 nM
|
|
|
|
CP0398152
|
N-[(4-tert-butylphenyl)methyl]-2-(4-hydroxy-2-iodo-5-methoxyphenyl)acetamide
Show/Hide
|
C20H24INO3
|
1
|
| 1 |
Ki = 850 nM
|
|
|
|
CP0441319
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[(4-methylphenyl)methyl]propanamide
Show/Hide
|
C18H21FN2O3S
|
2
|
| 1 |
Ki = 930 nM
|
|
|
| 2 |
Ki = 3100 nM
|
|
|
|
CP0065226
|
2,2-Dimethyl-propionic acid 2-(3,4-dimethyl-benzyl)-3-{3-[4-(propane-1-sulfonylamino)-benzyl]-thioureido}-propyl ester
Show/Hide
|
C28H41N3O4S2
|
1
|
| 1 |
Ki = 940 nM
|
|
|
|
CP0432351
|
methyl 5-[1-[(4-tert-butylphenyl)methylamino]-1-oxopropan-2-yl]-2-(methanesulfonamido)benzoate
Show/Hide
|
C23H30N2O5S
|
2
|
| 1 |
Ki = 952 nM
|
|
|
| 2 |
Ki = 1606 nM
|
|
|
|
CP0377413
|
3-[(4-tert-butylphenyl)methyl]-1-[2-(3-fluoro-4-methanesulfonamidophenyl)propan-2-yl]thiourea
Show/Hide
|
C22H30FN3O2S2
|
2
|
| 1 |
Ki = 980 nM
|
|
|
| 2 |
Ki = 7700 nM
|
|
|
|
CP0416913
|
N-[(4-tert-butylphenyl)methyl]-2-[2-chloro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C21H27ClN2O3S
|
2
|
| 1 |
Ki = 1420 nM
|
|
|
| 2 |
Ki = 4500 nM
|
|
|
|
CP0435535
|
1-[(4-tert-butylphenyl)methyl]-3-[4-(methanesulfonamido)anilino]thiourea
Show/Hide
|
C19H26N4O2S2
|
2
|
| 1 |
Ki = 1460 nM
|
|
|
| 2 |
Ki = 12100 nM
|
|
|
|
CP0422607
|
1-[(4-tert-butylphenyl)methyl]-3-[6-(methanesulfonamido)-1,2,3,4-tetrahydronaphthalen-1-yl]thiourea
Show/Hide
|
C23H31N3O2S2
|
2
|
| 1 |
Ki = 1590 nM
|
|
|
| 2 |
Ki = 2640 nM
|
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|
|
CP0393085
|
N-(2,2-diphenylethyl)-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C24H25FN2O3S
|
2
|
| 1 |
Ki = 1680 nM
|
|
|
| 2 |
Ki = 2490 nM
|
|
|
|
CP0422378
|
1-[(4-tert-butylphenyl)methyl]-3-[5-(methanesulfonamido)-4-methoxy-2,3-dihydro-1H-inden-1-yl]thiourea
Show/Hide
|
C23H31N3O3S2
|
2
|
| 1 |
Ki = 1690 nM
|
|
|
| 2 |
Ki = 1820 nM
|
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CP0502286
|
1-[(4-tert-butylphenyl)methyl]-3-[6-(methanesulfonamido)-5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl]thiourea
Show/Hide
|
C24H33N3O3S2
|
2
|
| 1 |
Ki = 1750 nM
|
|
|
| 2 |
Ki = 4700 nM
|
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|
|
CP0435896
|
3-[(4-tert-butylphenyl)methyl]-1-[2-(4-methanesulfonamidophenyl)propan-2-yl]thiourea
Show/Hide
|
C22H31N3O2S2
|
1
|
| 1 |
Ki = 1800 nM
|
|
|
|
CP0464666
|
1-(4-tert-butylanilino)-3-[[4-(methanesulfonamido)phenyl]methyl]thiourea
Show/Hide
|
C19H26N4O2S2
|
2
|
| 1 |
Ki = 2010 nM
|
|
|
| 2 |
Ki = 6400 nM
|
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|
|
CP0388736
|
2-(4-tert-butylphenyl)-N-[1-[3-fluoro-4-(methanesulfonamido)phenyl]ethyl]acetamide
Show/Hide
|
C21H27FN2O3S
|
2
|
| 1 |
Ki = 2100 nM
|
|
|
| 2 |
Ki = 2220 nM
|
|
|
|
CP0377411
|
3-[(4-tert-butylphenyl)methyl]-1-[(1S)-1-(3-fluoro-4-methanesulfonamidophenyl)ethyl]thiourea
Show/Hide
|
C21H28FN3O2S2
|
2
|
| 1 |
Ki = 2140 nM
|
|
|
| 2 |
Ki = 2670 nM
|
|
|
|
CP0410342
|
2-[4-(2-aminoethoxy)-3-fluorophenyl]-N-[(4-tert-butylphenyl)methyl]propanamide
Show/Hide
|
C22H29FN2O2
|
1
|
| 1 |
Ki = 2160 nM
|
|
|
|
CP0469520
|
(4-Methanesulfonylamino-3-methoxy-benzyl)-thiocarbamic acid 4-tert-butyl-benzyl ester
Show/Hide
|
C21H28N2O4S2
|
2
|
| 1 |
Ki = 2170 nM
|
|
|
| 2 |
Ki = 8400 nM
|
|
|
|
CP0464668
|
1-[(4-tert-butylphenyl)methyl]-3-[[2-chloro-4-(methanesulfonamido)phenyl]methyl]-1-hydroxythiourea
Show/Hide
|
C20H26ClN3O3S2
|
1
|
| 1 |
Ki = 2270 nM
|
|
|
|
CP0410337
|
2-[4-(2-aminoethoxy)-3-chlorophenyl]-N-[(4-tert-butylphenyl)methyl]acetamide
Show/Hide
|
C21H27ClN2O2
|
1
|
| 1 |
Ki = 2470 nM
|
|
|
|
CP0493068
|
N-[3-(3,4-dimethylphenyl)propyl]-2-[3-fluoro-4-(methanesulfonamido)phenyl]acetamide
Show/Hide
|
C20H25FN2O3S
|
2
|
| 1 |
Ki = 2710 nM
|
|
|
| 2 |
Ki = 4656 nM
|
|
|
|
CP0373354
|
1-[(4-tert-butylphenyl)methyl]-3-[5-(methanesulfonamido)-6-methoxy-2,3-dihydro-1H-inden-1-yl]thiourea
Show/Hide
|
C23H31N3O3S2
|
2
|
| 1 |
Ki = 3370 nM
|
|
|
| 2 |
Ki = 25000 nM
|
|
|
|
CP0248039
|
[(2R)-2-benzyl-3-[[(1S)-1-[4-(methanesulfonamido)phenyl]ethyl]carbamothioylamino]propyl] 2,2-dimethylpropanoate
Show/Hide
|
C25H35N3O4S2
|
1
|
| 1 |
Ki = 3500 nM
|
|
|
|
CP0486050
|
1-[(4-tert-butylphenyl)methyl]-3-[[4-(methanesulfonamido)-3-propan-2-yloxyphenyl]methyl]thiourea
Show/Hide
|
C23H33N3O3S2
|
2
|
| 1 |
Ki = 3600 nM
|
|
|
| 2 |
Ki = 8072 nM
|
|
|
|
CP0416912
|
N-benzyl-5-[1-[(4-tert-butylphenyl)methylamino]-1-oxopropan-2-yl]-2-(methanesulfonamido)benzamide
Show/Hide
|
C29H35N3O4S
|
1
|
| 1 |
Ki = 3710 nM
|
|
|
|
CP0377412
|
3-[(4-tert-butylphenyl)methyl]-1-[(1S)-1-(4-methanesulfonamidophenyl)ethyl]thiourea
Show/Hide
|
C21H29N3O2S2
|
1
|
| 1 |
Ki = 3950 nM
|
|
|
|
CP0461512
|
1-[(4-tert-butylphenyl)methyl]-3-[[5-(methanesulfonamido)pyridin-2-yl]methyl]thiourea
Show/Hide
|
C19H26N4O2S2
|
2
|
| 1 |
Ki = 4100 nM
|
|
|
| 2 |
Ki = 11900 nM
|
|
|
|
CP0504658
|
3-[2-(4-Acetoxy-3-iodo-5-methoxyphenyl)acetamido]-2-(3,4-dimethylbenzyl)propyl pivalate
Show/Hide
|
C28H36INO6
|
1
|
| 1 |
Ki = 4530 nM
|
|
|
|
CP0439450
|
(4-Methanesulfonylamino-benzyl)-thiocarbamic acid 4-tert-butyl-benzyl ester
Show/Hide
|
C20H26N2O3S2
|
2
|
| 1 |
Ki = 4600 nM
|
|
|
| 2 |
Ki = 6250 nM
|
|
|
|
CP0435536
|
2-Amino-ethanesulfonic acid {4-[3-(4-tert-butyl-benzyl)-thioureidomethyl]-phenyl}-amide
Show/Hide
|
C21H30N4O2S2
|
1
|
| 1 |
Ki = 4640 nM
|
|
|
|
CP0439451
|
2-(4-tert-Butyl-phenyl)-N-(4-methanesulfonylamino-benzyl)-acetamide
Show/Hide
|
C20H26N2O3S
|
2
|
| 1 |
Ki = 5220 nM
|
|
|
| 2 |
Ki = 6760 nM
|
|
|
|
CP0388744
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-[(4-methoxyphenyl)methyl]propanamide
Show/Hide
|
C18H21FN2O4S
|
2
|
| 1 |
Ki = 5350 nM
|
|
|
| 2 |
Ki = 7800 nM
|
|
|
|
CP0506081
|
N-benzhydryl-2-[3-fluoro-4-(methanesulfonamido)phenyl]propanamide
Show/Hide
|
C23H23FN2O3S
|
1
|
| 1 |
Ki = 5900 nM
|
|
|
|
CP0445471
|
N-[(4-tert-butylphenyl)methyl]-N-hydroxy-2-[4-(methanesulfonamido)phenyl]acetamide
Show/Hide
|
C20H26N2O4S
|
2
|
| 1 |
Ki = 6400 nM
|
|
|
| 2 |
Ki = 6600 nM
|
|
|
|
CP0409392
|
tert-butyl 5-[1-[(4-tert-butylphenyl)methylamino]-1-oxopropan-2-yl]-2-(methanesulfonamido)benzoate
Show/Hide
|
C26H36N2O5S
|
1
|
| 1 |
Ki = 6700 nM
|
|
|
|
CP0464663
|
1-[(4-tert-butylphenyl)methyl]-3-[4-(methanesulfonamido)phenyl]thiourea
Show/Hide
|
C19H25N3O2S2
|
2
|
| 1 |
Ki = 6800 nM
|
|
|
| 2 |
Ki = 9560 nM
|
|
|
|
CP0497700
|
1-[(4-tert-butylphenyl)methyl]-3-[6-(methanesulfonamido)-7-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl]thiourea
Show/Hide
|
C24H33N3O3S2
|
1
|
| 1 |
Ki = 6900 nM
|
|
|
|
CP0433539
|
tert-butyl 4-[5-[1-[(4-tert-butylphenyl)methylamino]-1-oxopropan-2-yl]-2-(methanesulfonamido)phenyl]piperazine-1-carboxylate
Show/Hide
|
C30H44N4O5S
|
1
|
| 1 |
Ki = 7000 nM
|
|
|
|
CP0449081
|
N-[3-(3,4-dimethylphenyl)propyl]-2-[4-(methanesulfonamido)phenyl]acetamide
Show/Hide
|
C20H26N2O3S
|
2
|
| 1 |
Ki = 7180 nM
|
|
|
| 2 |
Ki = 13555 nM
|
|
|
|
CP0510718
|
2-[3-fluoro-4-(methanesulfonamido)phenyl]-N-phenylmethoxypropanamide
Show/Hide
|
C17H19FN2O4S
|
1
|
| 1 |
Ki = 9400 nM
|
|
|
|
CP0410341
|
2-[4-(2-aminoethoxy)-3-fluorophenyl]-N-[(4-tert-butylphenyl)methyl]acetamide
Show/Hide
|
C21H27FN2O2
|
1
|
| 1 |
Ki = 10100 nM
|
|
|
|
CP0446661
|
2-(4-Methanesulfonylamino-phenyl)-N-octadec-9-enyl-acetamide
Show/Hide
|
C27H46N2O3S
|
1
|
| 1 |
Ki > 25000 nM
|
|
|
