Protein Information

General Information of the Protein

Protein ID	PT02118
Protein Name	Neuronal acetylcholine receptor subunit alpha-7
Gene Name	CHRNA7
Secondarily Gene Name	Acra7
Sequence	MCGGRGGIWLALAAALLHVSLQGEFQRRLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNMSEYPGVKNVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNASGHCQYLPPGIFKSSCYIDVRWFPFDVQQCKLKFGSWSYGGWSLDLQMQEADISSYIPNGEWDLMGIPGKRNEKFYECCKEPYPDVTYTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLRYHHHDPDGGKMPKWTRIILLNWCAWFLRMKRPGEDKVRPACQHKPRRCSLASVELSAGAGPPTSNGNLLYIGFRGLEGMHCAPTPDSGVVCGRLACSPTHDEHLMHGAHPSDGDPDLAKILEEVRYIANRFRCQDESEVICSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA Show/Hide
Organism	Rattus norvegicus, Rat
Protein Classification	Ion channel > Ligand-gated ion channel > Nicotinic acetylcholine receptor > Nicotinic acetylcholine receptor alpha subunit
Function	After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin. Show/Hide
Uniprot ID	Primary ID: Q05941 Secondarily ID: Q53YK2 Show/Hide
Ensembl ID	ENSG00000175344
Subcellular Location	Postsynaptic cell membrane Cell membrane

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000029 , GH4C1

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0008526 Compound Info	N-[(2S,3R)-2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]octan-3-yl]-5-thiophen-2-ylthiophene-2-carboxamide Show/Hide	C22H23N3OS2	1
1	EC50 = 1 nM Bioactivity Info	TI LI LO TS
CP0013413 Compound Info	5-iodo-N-[(2S,3R)-2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]octan-3-yl]thiophene-2-carboxamide Show/Hide	C18H20IN3OS	1
1	EC50 = 1 nM Bioactivity Info	TI LI LO TS
CP0011142 Compound Info	5-bromo-N-[(2S,3R)-2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]octan-3-yl]thiophene-2-carboxamide Show/Hide	C18H20BrN3OS	1
1	EC50 = 11 nM Bioactivity Info	TI LI LO TS
CP0011172 Compound Info	7-methoxy-N-[(2S,3R)-2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]octan-3-yl]-1-benzofuran-2-carboxamide Show/Hide	C23H25N3O3	1
1	EC50 = 12 nM Bioactivity Info	TI LI LO TS
CP0010514 Compound Info	(E)-3-(3-methylthiophen-2-yl)-N-[(2S,3R)-2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]octan-3-yl]prop-2-enamide Show/Hide	C21H25N3OS	1
1	EC50 = 14 nM Bioactivity Info	TI LI LO TS
CP0011146 Compound Info	(E)-3-phenyl-N-[(2S,3R)-2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]octan-3-yl]prop-2-enamide Show/Hide	C22H25N3O	1
1	EC50 = 14 nM Bioactivity Info	TI LI LO TS
CP0011140 Compound Info	N-[(2S,3R)-2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]octan-3-yl]-1-benzofuran-2-carboxamide Show/Hide	C22H23N3O2	1
1	EC50 = 17 nM Bioactivity Info	TI LI LO TS
CP0006359 Compound Info	Benzofuran-2-carboxylic acid ((2R,3R)-2-pyridin-3-ylmethyl-1-aza-bicyclo[2.2.2]oct-3-yl)-amide Show/Hide	C22H23N3O2	1
1	EC50 = 20 nM Bioactivity Info	TI LI LO TS
CP0008443 Compound Info	(1S,4S)-2-methyl-5-(6-phenylpyridazin-3-yl)-2,5-diazabicyclo[2.2.1]heptane Show/Hide	C16H18N4	1
1	EC50 = 25 nM Bioactivity Info	TI LI LO TS
CP0008432 Compound Info	5-pyridin-2-yl-N-[(2S,3R)-2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]octan-3-yl]thiophene-2-carboxamide Show/Hide	C23H24N4OS	1
1	EC50 = 30 nM Bioactivity Info	TI LI LO TS
CP0009257 Compound Info	5-hydroxy-N-[(2S,3R)-2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]octan-3-yl]-1-benzofuran-2-carboxamide Show/Hide	C22H23N3O3	1
1	EC50 = 30 nM Bioactivity Info	TI LI LO TS
CP0009988 Compound Info	5-methyl-N-[(2S,3R)-2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]octan-3-yl]thiophene-2-carboxamide Show/Hide	C19H23N3OS	1
1	EC50 = 30 nM Bioactivity Info	TI LI LO TS
CP0506428 Compound Info	PHA568487 Show/Hide	C16H20N2O3	1
1	EC50 = 36.2 nM Bioactivity Info	TI LI LO TS
CP0004233 Compound Info	5-fluoro-3-methyl-N-[(2S,3R)-2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]octan-3-yl]-1-benzofuran-2-carboxamide Show/Hide	C23H24FN3O2	1
1	EC50 = 50 nM Bioactivity Info	TI LI LO TS
CP0006371 Compound Info	5-fluoro-N-[(2S,3R)-2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]octan-3-yl]-1-benzofuran-2-carboxamide Show/Hide	C22H22FN3O2	1
1	EC50 = 50 nM Bioactivity Info	TI LI LO TS
CP0009990 Compound Info	N-[(2S,3R)-2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]octan-3-yl]isoquinoline-3-carboxamide Show/Hide	C23H24N4O	1
1	EC50 = 50 nM Bioactivity Info	TI LI LO TS
CP0012452 Compound Info	3-methyl-N-[(2S,3R)-2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]octan-3-yl]-1-benzofuran-2-carboxamide Show/Hide	C23H25N3O2	1
1	EC50 = 50 nM Bioactivity Info	TI LI LO TS
CP0001671 Compound Info	4-methoxy-N-[(2S,3R)-2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]octan-3-yl]benzamide Show/Hide	C21H25N3O2	1
1	EC50 = 60 nM Bioactivity Info	TI LI LO TS
CP0006355 Compound Info	4-bromo-N-[(2S,3R)-2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]octan-3-yl]benzamide Show/Hide	C20H22BrN3O	1
1	EC50 = 60 nM Bioactivity Info	TI LI LO TS
CP0009987 Compound Info	5-chloro-N-[(2S,3R)-2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]octan-3-yl]-1-benzofuran-2-carboxamide Show/Hide	C22H22ClN3O2	1
1	EC50 = 60 nM Bioactivity Info	TI LI LO TS
CP0035744 Compound Info	1-[6-(4-Fluorophenyl)pyridin-3-yl]-3-(4-piperidin-1-ylbutyl)urea Show/Hide	C21H27FN4O	3
1	EC50 = 70 nM Bioactivity Info	TI LI LO TS
2	EC50 = 490 nM Bioactivity Info	TI LI LO TS
3	Ki = 44 nM Bioactivity Info	TI LI LO TS
CP0492269 Compound Info	4'-(5-Piperidin-1-yl-pentanoylamino)biphenyl-3-carboxylic acid amide Show/Hide	C23H29N3O2	1
1	EC50 = 90 nM Bioactivity Info	TI LI LO TS
CP0006682 Compound Info	5-methyl-N-[(2S,3R)-2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]octan-3-yl]-1-benzofuran-2-carboxamide Show/Hide	C23H25N3O2	1
1	EC50 = 90 nM Bioactivity Info	TI LI LO TS
CP0009986 Compound Info	5-bromo-N-[(2S,3R)-2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]octan-3-yl]-1-benzofuran-2-carboxamide Show/Hide	C22H22BrN3O2	1
1	EC50 = 100 nM Bioactivity Info	TI LI LO TS
CP0011173 Compound Info	5-methoxy-N-[(2S,3R)-2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]octan-3-yl]-1-benzofuran-2-carboxamide Show/Hide	C23H25N3O3	1
1	EC50 = 100 nM Bioactivity Info	TI LI LO TS
CP0008058 Compound Info	6-methyl-N-[(2S,3R)-2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]octan-3-yl]-1-benzofuran-2-carboxamide Show/Hide	C23H25N3O2	1
1	EC50 = 110 nM Bioactivity Info	TI LI LO TS
CP0008060 Compound Info	N-[(2S,3R)-2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]octan-3-yl]-2,3-dihydro-1,4-benzodioxine-6-carboxamide Show/Hide	C22H25N3O3	1
1	EC50 = 110 nM Bioactivity Info	TI LI LO TS
CP0013411 Compound Info	7-fluoro-3-methyl-N-[(2S,3R)-2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]octan-3-yl]-1-benzofuran-2-carboxamide Show/Hide	C23H24FN3O2	1
1	EC50 = 110 nM Bioactivity Info	TI LI LO TS
CP0398920 Compound Info	5-Piperidin-1-ylpentanoic acid(3'-acetylaminobiphenyl-4-yl)amide Show/Hide	C24H31N3O2	1
1	EC50 = 120 nM Bioactivity Info	TI LI LO TS
CP0135708 Compound Info	1-(4-(6-fluoropyridin-3-yl)phenyl)-3-(4-(piperidin-1-yl)butyl)urea Show/Hide	C21H27FN4O	1
1	EC50 = 120 nM Bioactivity Info	TI LI LO TS
CP0269304 Compound Info	1-(6-phenylpyridin-3-yl)-3-(4-(piperidin-1-yl)butyl)urea Show/Hide	C21H28N4O	1
1	EC50 = 120 nM Bioactivity Info	TI LI LO TS
CP0497463 Compound Info	1-(4-Piperidin-1-yl)butyl-3-(4-pyridin-3-ylphenyl)urea Show/Hide	C21H28N4O	1
1	EC50 = 120 nM Bioactivity Info	TI LI LO TS
CP0009984 Compound Info	5-chloro-3-methyl-N-[(2S,3R)-2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]octan-3-yl]-1-benzofuran-2-carboxamide Show/Hide	C23H24ClN3O2	1
1	EC50 = 120 nM Bioactivity Info	TI LI LO TS
CP0011420 Compound Info	5-(4-acetyl-1,4-diazepan-1-yl)-N-[5-(4-methoxyphenyl)-1H-pyrazol-3-yl]pentanamide Show/Hide	C22H31N5O3	4
1	EC50 = 125.89 nM Bioactivity Info	TI LI LO TS
2	EC50 = 180 nM Bioactivity Info	TI LI LO TS
3	EC50 = 4400 nM Bioactivity Info	TI LI LO TS
4	Ki = 660 nM Bioactivity Info	TI LI LO TS
CP0005582 Compound Info	(1S,4S)-2-methyl-5-(4-pyridin-3-ylphenyl)-2,5-diazabicyclo[2.2.1]heptane Show/Hide	C17H19N3	1
1	EC50 = 126 nM Bioactivity Info	TI LI LO TS
CP0066095 Compound Info	1-(2'-fluorobiphenyl-4-yl)-3-(4-(piperidin-1-yl)butyl)urea Show/Hide	C22H28FN3O	1
1	EC50 = 130 nM Bioactivity Info	TI LI LO TS
CP0269311 Compound Info	1-(4-Piperidin-1-ylbutyl)-3-(4-pyridin-2-ylphenyl)urea Show/Hide	C21H28N4O	1
1	EC50 = 130 nM Bioactivity Info	TI LI LO TS
CP0013412 Compound Info	5-phenyl-N-[(2S,3R)-2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]octan-3-yl]thiophene-2-carboxamide Show/Hide	C24H25N3OS	1
1	EC50 = 130 nM Bioactivity Info	TI LI LO TS
CP0269306 Compound Info	1-(2'-methoxybiphenyl-4-yl)-3-(4-(piperidin-1-yl)butyl)urea Show/Hide	C23H31N3O2	1
1	EC50 = 140 nM Bioactivity Info	TI LI LO TS
CP0006681 Compound Info	N-[(2R,3S)-2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]octan-3-yl]-1-benzofuran-2-carboxamide Show/Hide	C22H23N3O2	1
1	EC50 = 140 nM Bioactivity Info	TI LI LO TS
CP0008057 Compound Info	7-(2-methoxyphenyl)-N-[(2S,3R)-2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]octan-3-yl]-1-benzofuran-2-carboxamide Show/Hide	C29H29N3O3	1
1	EC50 = 140 nM Bioactivity Info	TI LI LO TS
CP0006719 Compound Info	N-[4-(2-fluoropyridin-3-yl)phenyl]-5-morpholin-4-ylpentanamide Show/Hide	C20H24FN3O2	2
1	EC50 = 145 nM Bioactivity Info	TI LI LO TS
2	EC50 = 27300 nM Bioactivity Info	TI LI LO TS
CP0035594 Compound Info	1-(6-(2-fluorophenyl)pyridin-3-yl)-3-(4-(piperidin-1-yl)butyl)urea Show/Hide	C21H27FN4O	1
1	EC50 = 150 nM Bioactivity Info	TI LI LO TS
CP0443264 Compound Info	5-Piperidin-1-yl-pentanoic acid(2',4'-difluorobiphenyl-4-yl)amide Show/Hide	C22H26F2N2O	1
1	EC50 = 160 nM Bioactivity Info	TI LI LO TS
CP0008527 Compound Info	5-phenyl-N-[(2S,3R)-2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]octan-3-yl]furan-2-carboxamide Show/Hide	C24H25N3O2	1
1	EC50 = 160 nM Bioactivity Info	TI LI LO TS
CP0869923 Compound Info	1-(4-bromophenyl)-3-(8-methyl-8-aza-bicyclo[3.2.1]octan-3-yl)urea Show/Hide	C15H20BrN3O	1
1	EC50 = 200 nM Bioactivity Info	TI LI LO TS
CP0009214 Compound Info	4-chloro-N-[(2S,3R)-2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]octan-3-yl]benzamide Show/Hide	C20H22ClN3O	1
1	EC50 = 200 nM Bioactivity Info	TI LI LO TS
CP0011147 Compound Info	3-bromo-N-[(2S,3R)-2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]octan-3-yl]furan-2-carboxamide Show/Hide	C18H20BrN3O2	1
1	EC50 = 200 nM Bioactivity Info	TI LI LO TS
CP0288507 Compound Info	1-(4'-fluorobiphenyl-4-yl)-3-(4-(piperidin-1-yl)butyl)urea Show/Hide	C22H28FN3O	1
1	EC50 = 220 nM Bioactivity Info	TI LI LO TS
CP0135915 Compound Info	1-(6-(2-methoxyphenyl)pyridin-3-yl)-3-(4-(piperidin-1-yl)butyl)urea Show/Hide	C22H30N4O2	1
1	EC50 = 230 nM Bioactivity Info	TI LI LO TS
CP0000471 Compound Info	N-[(2S,3R)-2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]octan-3-yl]quinoline-2-carboxamide Show/Hide	C23H24N4O	1
1	EC50 = 230 nM Bioactivity Info	TI LI LO TS
CP0492271 Compound Info	5-Piperidin-1-yl-pentanoic acid(2'-isopropoxybiphenyl-4-yl)amide Show/Hide	C25H34N2O2	1
1	EC50 = 240 nM Bioactivity Info	TI LI LO TS
CP0007954 Compound Info	(1S,4S)-2-methyl-5-(4-phenylphenyl)-2,5-diazabicyclo[2.2.1]heptane Show/Hide	C18H20N2	1
1	EC50 = 253 nM Bioactivity Info	TI LI LO TS
CP0135912 Compound Info	1-(biphenyl-4-yl)-3-(4-(piperidin-1-yl)butyl)urea Show/Hide	C22H29N3O	1
1	EC50 = 260 nM Bioactivity Info	TI LI LO TS
CP0008059 Compound Info	5-chloro-N-[(2S,3R)-2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]octan-3-yl]pyridine-2-carboxamide Show/Hide	C19H21ClN4O	1
1	EC50 = 270 nM Bioactivity Info	TI LI LO TS
CP0000469 Compound Info	7-pyridin-2-yl-N-[(2S,3R)-2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]octan-3-yl]-1-benzofuran-2-carboxamide Show/Hide	C27H26N4O2	1
1	EC50 = 280 nM Bioactivity Info	TI LI LO TS
CP0010516 Compound Info	3,4-dichloro-N-[(2S,3R)-2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]octan-3-yl]benzamide Show/Hide	C20H21Cl2N3O	1
1	EC50 = 300 nM Bioactivity Info	TI LI LO TS
CP0007770 Compound Info	5-(piperidin-1-yl)-N-(4-(pyridin-3-yl)phenyl)pentanamide Show/Hide	C21H27N3O	2
1	EC50 = 350 nM Bioactivity Info	TI LI LO TS
2	EC50 = 530 nM Bioactivity Info	TI LI LO TS
CP0003699 Compound Info	5-(4-acetyl-1,4-diazepan-1-yl)-N-[5-(4-methoxyphenyl)-1H-pyrazol-3-yl]-2-methylpentanamide Show/Hide	C23H33N5O3	1
1	EC50 = 360 nM Bioactivity Info	TI LI LO TS
CP0066093 Compound Info	1-(2,2'-bipyridin-5-yl)-3-(4-(piperidin-1-yl)butyl)urea Show/Hide	C20H27N5O	1
1	EC50 = 390 nM Bioactivity Info	TI LI LO TS
CP0004234 Compound Info	4-phenyl-N-[(2S,3R)-2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]octan-3-yl]thiophene-2-carboxamide Show/Hide	C24H25N3OS	1
1	EC50 = 390 nM Bioactivity Info	TI LI LO TS
CP0010518 Compound Info	4-hydroxy-N-[(2S,3R)-2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]octan-3-yl]benzamide Show/Hide	C20H23N3O2	1
1	EC50 = 400 nM Bioactivity Info	TI LI LO TS
CP0003287 Compound Info	N-[5-(4-methoxyphenyl)-1H-pyrazol-3-yl]-4-piperidin-1-ylbutanamide Show/Hide	C19H26N4O2	1
1	EC50 = 416.87 nM Bioactivity Info	TI LI LO TS
CP0009928 Compound Info	N-[5-(4-methoxyphenyl)-1H-pyrazol-3-yl]-5-piperidin-1-ylpentanamide Show/Hide	C20H28N4O2	1
1	EC50 = 430 nM Bioactivity Info	TI LI LO TS
CP0009993 Compound Info	N-[5-(3-methoxyphenyl)-1H-pyrazol-3-yl]-4-piperidin-1-ylbutanamide Show/Hide	C19H26N4O2	1
1	EC50 = 467.74 nM Bioactivity Info	TI LI LO TS
CP0416419 Compound Info	1-(4-(Morpholin-4-yl)butyl)-3-(4-pyridin-3-ylphenyl)urea Show/Hide	C20H26N4O2	1
1	EC50 = 490 nM Bioactivity Info	TI LI LO TS
CP0005714 Compound Info	4-chloro-N-[(2S,3R)-2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]octan-3-yl]pyridine-2-carboxamide Show/Hide	C19H21ClN4O	1
1	EC50 = 500 nM Bioactivity Info	TI LI LO TS
CP0009985 Compound Info	3,5-dimethyl-N-[(2S,3R)-2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]octan-3-yl]-1-benzofuran-2-carboxamide Show/Hide	C24H27N3O2	1
1	EC50 = 500 nM Bioactivity Info	TI LI LO TS
CP0003309 Compound Info	5-morpholin-4-yl-N-(4-pyridin-4-ylphenyl)pentanamide Show/Hide	C20H25N3O2	1
1	EC50 = 522 nM Bioactivity Info	TI LI LO TS
CP0135706 Compound Info	1-(6'-fluoro-2,3'-bipyridin-5-yl)-3-(4-(piperidin-1-yl)butyl)urea Show/Hide	C20H26FN5O	1
1	EC50 = 530 nM Bioactivity Info	TI LI LO TS
CP0510443 Compound Info	5-Azepan-1-ylpentanoic acid(4-pyridin-3-yl-phenyl)amide Show/Hide	C22H29N3O	1
1	EC50 = 540 nM Bioactivity Info	TI LI LO TS
CP0009929 Compound Info	N-[5-(4-methoxyphenyl)-1H-pyrazol-3-yl]-5-morpholin-4-ylpentanamide Show/Hide	C19H26N4O3	1
1	EC50 = 590 nM Bioactivity Info	TI LI LO TS
CP0528176 Compound Info	1-azabicyclo[2.2.2]octan-3-yl N-(2-fluorophenyl)carbamate Show/Hide	C14H17FN2O2	1
1	EC50 = 600 nM Bioactivity Info	TI LI LO TS
CP0005715 Compound Info	2,6-difluoro-4-methoxy-N-[(2S,3R)-2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]octan-3-yl]benzamide Show/Hide	C21H23F2N3O2	1
1	EC50 = 600 nM Bioactivity Info	TI LI LO TS
CP0010367 Compound Info	3-chloro-N-[(2S,3R)-2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]octan-3-yl]benzamide Show/Hide	C20H22ClN3O	1
1	EC50 = 600 nM Bioactivity Info	TI LI LO TS
CP0009434 Compound Info	N-[(2S,3R)-2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]octan-3-yl]pyridine-2-carboxamide Show/Hide	C19H22N4O	1
1	EC50 = 650 nM Bioactivity Info	TI LI LO TS
CP0003419 Compound Info	N-[5-(4-methoxyphenyl)-1H-pyrazol-3-yl]-5-(1,4-oxazepan-4-yl)pentanamide Show/Hide	C20H28N4O3	1
1	EC50 = 670 nM Bioactivity Info	TI LI LO TS
CP0005233 Compound Info	5-Morpholin-4-ylpentanoic acid(4-pyridin-3-ylphenyl)amide hydrochloride Show/Hide	C20H25N3O2	3
1	EC50 = 687 nM Bioactivity Info	TI LI LO TS
2	EC50 = 1650 nM Bioactivity Info	TI LI LO TS
3	EC50 = 42000 nM Bioactivity Info	TI LI LO TS
CP0006345 Compound Info	4-fluoro-N-[(2S,3R)-2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]octan-3-yl]benzamide Show/Hide	C20H22FN3O	1
1	EC50 = 700 nM Bioactivity Info	TI LI LO TS
CP0010366 Compound Info	4-(dimethylamino)-N-[(2S,3R)-2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]octan-3-yl]benzamide Show/Hide	C22H28N4O	1
1	EC50 = 700 nM Bioactivity Info	TI LI LO TS
CP0003697 Compound Info	1-[4-(4-chlorophenyl)phenyl]-3-(4-piperidin-1-ylbutyl)urea Show/Hide	C22H28ClN3O	1
1	EC50 = 780 nM Bioactivity Info	TI LI LO TS
CP0003286 Compound Info	N-[5-(3-fluorophenyl)-1H-pyrazol-3-yl]-4-piperidin-1-ylbutanamide Show/Hide	C18H23FN4O	1
1	EC50 = 831.76 nM Bioactivity Info	TI LI LO TS
CP0010365 Compound Info	5-pyridin-2-yl-N-[(2S,3R)-2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]octan-3-yl]furan-2-carboxamide Show/Hide	C23H24N4O2	1
1	EC50 = 850 nM Bioactivity Info	TI LI LO TS
CP0372275 Compound Info	6-Piperidin-1-ylhexanoic acid(4-pyridin-3-yl-phenyl)-amide Show/Hide	C22H29N3O	1
1	EC50 = 890 nM Bioactivity Info	TI LI LO TS
CP0006365 Compound Info	4-(azepan-1-yl)-N-[5-(4-methoxyphenyl)-1H-pyrazol-3-yl]butanamide Show/Hide	C20H28N4O2	1
1	EC50 = 912.01 nM Bioactivity Info	TI LI LO TS
CP0459155 Compound Info	4-(4-acetyl-1,4-diazepan-1-yl)-N-[5-(4-methoxyphenyl)-1H-pyrazol-3-yl]butanamide Show/Hide	C21H29N5O3	1
1	EC50 = 912.01 nM Bioactivity Info	TI LI LO TS
CP0000470 Compound Info	7-bromo-5-chloro-N-[(2S,3R)-2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]octan-3-yl]-1-benzofuran-2-carboxamide Show/Hide	C22H21BrClN3O2	1
1	EC50 = 960 nM Bioactivity Info	TI LI LO TS
CP0469526 Compound Info	5-Piperidin-1-ylpentanoic acid(3'-acetylbiphenyl-4-yl)amide Show/Hide	C24H30N2O2	1
1	EC50 = 990 nM Bioactivity Info	TI LI LO TS
CP0005787 Compound Info	N-[4-(1H-indol-5-yl)phenyl]-5-morpholin-4-ylpentanamide Show/Hide	C23H27N3O2	1
1	EC50 = 997 nM Bioactivity Info	TI LI LO TS
CP0011175 Compound Info	4-(hydroxymethyl)-N-[(2S,3R)-2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]octan-3-yl]benzamide Show/Hide	C21H25N3O2	1
1	EC50 = 1000 nM Bioactivity Info	TI LI LO TS
CP0004176 Compound Info	5-(azepan-1-yl)-N-[5-(4-methoxyphenyl)-1H-pyrazol-3-yl]pentanamide Show/Hide	C21H30N4O2	1
1	EC50 = 1050 nM Bioactivity Info	TI LI LO TS
CP0000063 Compound Info	CAS_29790-52-1 Show/Hide	C10H14N2	4
1	EC50 = 1071.52 nM Bioactivity Info	TI LI LO TS
2	EC50 = 1500 nM Bioactivity Info	TI LI LO TS
3	EC50 = 23000 nM Bioactivity Info	TI LI LO TS
4	Ki = 6290 nM Bioactivity Info	TI LI LO TS
CP0010034 Compound Info	N-[(2S,3R)-2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]octan-3-yl]benzamide Show/Hide	C20H23N3O	1
1	EC50 = 1100 nM Bioactivity Info	TI LI LO TS
CP0012399 Compound Info	N-[5-(4-bromophenyl)-1H-pyrazol-3-yl]-5-piperidin-1-ylpentanamide Show/Hide	C19H25BrN4O	1
1	EC50 = 1150 nM Bioactivity Info	TI LI LO TS
CP0009994 Compound Info	N-[5-(4-methoxyphenyl)-1H-pyrazol-3-yl]-4-(1,4-oxazepan-4-yl)butanamide Show/Hide	C19H26N4O3	1
1	EC50 = 1174.9 nM Bioactivity Info	TI LI LO TS
CP0001661 Compound Info	2-spiro[1,4-dihydroimidazole-5,3'-1-azabicyclo[2.2.2]octane]-2-yl-1-benzofuran-3-amine Show/Hide	C17H20N4O	1
1	EC50 = 1200 nM Bioactivity Info	TI LI LO TS
CP0009989 Compound Info	4-chloro-N-[(2S,3R)-2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]octan-3-yl]furan-2-carboxamide Show/Hide	C18H20ClN3O2	1
1	EC50 = 1200 nM Bioactivity Info	TI LI LO TS
CP0011143 Compound Info	5-bromo-N-[(2S,3R)-2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]octan-3-yl]furan-2-carboxamide Show/Hide	C18H20BrN3O2	1
1	EC50 = 1200 nM Bioactivity Info	TI LI LO TS
CP0480914 Compound Info	6-(4-acetyl-1,4-diazepan-1-yl)-N-[5-(4-methoxyphenyl)-1H-pyrazol-3-yl]hexanamide Show/Hide	C23H33N5O3	1
1	EC50 = 1202.26 nM Bioactivity Info	TI LI LO TS
CP0011418 Compound Info	N-[4-(4-chlorophenyl)phenyl]-5-piperidin-1-ylpentanamide Show/Hide	C22H27ClN2O	1
1	EC50 = 1220 nM Bioactivity Info	TI LI LO TS
CP0430999 Compound Info	5-Piperidin-1-yl-pentanoic acid(4-bromophenyl)amide Show/Hide	C22H27BrN2O	1
1	EC50 = 1350 nM Bioactivity Info	TI LI LO TS
CP0010006 Compound Info	N-[5-(2-methoxyphenyl)-1H-pyrazol-3-yl]-5-piperidin-1-ylpentanamide Show/Hide	C20H28N4O2	1
1	EC50 = 1450 nM Bioactivity Info	TI LI LO TS
CP0006360 Compound Info	5-chloro-3-methoxy-N-[(2S,3R)-2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]octan-3-yl]-1-benzofuran-2-carboxamide Show/Hide	C23H24ClN3O3	1
1	EC50 = 1500 nM Bioactivity Info	TI LI LO TS
CP0008064 Compound Info	N-[5-(4-fluorophenyl)-1H-pyrazol-3-yl]-5-piperidin-1-ylpentanamide Show/Hide	C19H25FN4O	1
1	EC50 = 1520 nM Bioactivity Info	TI LI LO TS
CP0635625 Compound Info	3-methoxy-4-((2-(pyridin-3-yl)-5,6-dihydropyridin-3(4H)-ylidene)methyl)phenol Show/Hide	C18H18N2O2	1
1	EC50 = 1600 nM Bioactivity Info	TI LI LO TS
CP0011960 Compound Info	N-[5-(4-methoxyphenyl)-1H-pyrazol-3-yl]-5-(4-methylpiperidin-1-yl)pentanamide Show/Hide	C21H30N4O2	1
1	EC50 = 1600 nM Bioactivity Info	TI LI LO TS
CP0636947 Compound Info	5-Morpholin-4-ylpentanoic acid(4-pyridin-3-ylphenyl)amide hydrochloride Show/Hide	C20H26ClN3O2	3
1	EC50 = 1650 nM Bioactivity Info	TI LI LO TS
2	EC50 = 12000 nM Bioactivity Info	TI LI LO TS
3	Ki = 260 nM Bioactivity Info	TI LI LO TS
CP0399607 Compound Info	3-[2-[(4-bromophenyl)methyl]-6-methylbenzimidazol-1-yl]-N,N-dimethylpropan-1-amine Show/Hide	C20H24BrN3	1
1	EC50 = 1700 nM Bioactivity Info	TI LI LO TS
CP0010005 Compound Info	N-[5-(3-methoxyphenyl)-1H-pyrazol-3-yl]-5-piperidin-1-ylpentanamide Show/Hide	C20H28N4O2	1
1	EC50 = 1700 nM Bioactivity Info	TI LI LO TS
CP0011174 Compound Info	3-fluoro-4-hydroxy-N-[(2S,3R)-2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]octan-3-yl]benzamide Show/Hide	C20H22FN3O2	1
1	EC50 = 1700 nM Bioactivity Info	TI LI LO TS
CP0469525 Compound Info	5-Piperidin-1-yl-pentanoic acid(3-bromophenyl)amide Show/Hide	C22H27BrN2O	1
1	EC50 = 2070 nM Bioactivity Info	TI LI LO TS
CP0011416 Compound Info	N-[5-(4-chlorophenyl)-1H-pyrazol-3-yl]-5-piperidin-1-ylpentanamide Show/Hide	C19H25ClN4O	1
1	EC50 = 2130 nM Bioactivity Info	TI LI LO TS
CP0002023 Compound Info	2-chloro-N-[(2S,3R)-2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]octan-3-yl]benzamide Show/Hide	C20H22ClN3O	1
1	EC50 = 2300 nM Bioactivity Info	TI LI LO TS
CP0011419 Compound Info	N-[4-(4-chlorophenyl)-1,3-thiazol-2-yl]-5-piperidin-1-ylpentanamide Show/Hide	C19H24ClN3OS	1
1	EC50 = 2330 nM Bioactivity Info	TI LI LO TS
CP0398874 Compound Info	5-[4-(2-Methoxyphenyl)piperazin-1-yl]pentanoic acid(4-pyridin-3-ylphenyl)amide Show/Hide	C27H32N4O2	1
1	EC50 = 2470 nM Bioactivity Info	TI LI LO TS
CP0454263 Compound Info	N,N-dimethyl-3-[2-(phenoxymethyl)benzimidazol-1-yl]propan-1-amine Show/Hide	C19H23N3O	1
1	EC50 = 2600 nM Bioactivity Info	TI LI LO TS
CP0485743 Compound Info	3-[2-[(4-bromophenyl)methyl]benzimidazol-1-yl]-N,N-dimethylpropan-1-amine Show/Hide	C19H22BrN3	1
1	EC50 = 2600 nM Bioactivity Info	TI LI LO TS
CP0492272 Compound Info	5-(4-Acetyl-[1,4]diazepan-1-yl)pentanoic acid(4-pyridin-3-yl-phenyl)amide Show/Hide	C23H30N4O2	1
1	EC50 = 2660 nM Bioactivity Info	TI LI LO TS
CP0422099 Compound Info	2-[(4-bromophenyl)methyl]-1-[2-(1-methylpyrrolidin-2-yl)ethyl]benzimidazole Show/Hide	C21H24BrN3	1
1	EC50 = 2700 nM Bioactivity Info	TI LI LO TS
CP0492273 Compound Info	5-(4-Acetylpiperazin-1-yl)pentanoic acid(4-pyridin-3-ylphenyl)amide Show/Hide	C22H28N4O2	1
1	EC50 = 2780 nM Bioactivity Info	TI LI LO TS
CP0424417 Compound Info	N-[4-[4-(2,4-dimethoxyphenyl)piperazin-1-yl]butyl]-4-pyridin-2-ylbenzamide Show/Hide	C28H34N4O3	1
1	EC50 = 2840 nM Bioactivity Info	TI LI LO TS
CP0405680 Compound Info	2'-Methoxybiphenyl-4-carboxylic acid{4-[4-(2,4-dimethoxyphenyl)piperazin-1-yl]butyl}amide Show/Hide	C30H37N3O4	1
1	EC50 = 2910 nM Bioactivity Info	TI LI LO TS
CP0005716 Compound Info	2-fluoro-N-[(2S,3R)-2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]octan-3-yl]benzamide Show/Hide	C20H22FN3O	1
1	EC50 = 3000 nM Bioactivity Info	TI LI LO TS
CP0009923 Compound Info	5-piperidin-1-yl-N-[5-[4-(trifluoromethyl)phenyl]-1H-pyrazol-3-yl]pentanamide Show/Hide	C20H25F3N4O	1
1	EC50 = 3070 nM Bioactivity Info	TI LI LO TS
CP0441474 Compound Info	2'-Chlorobiphenyl-4-carboxylic acid{4-[4-(2,4-dimethoxyphenyl)piperazin-1-yl]butyl}-amide Show/Hide	C29H34ClN3O3	1
1	EC50 = 3110 nM Bioactivity Info	TI LI LO TS
CP0000324 Compound Info	2-acetoxyethyl(trimethyl)ammonium;bromide Show/Hide	C7H16NO2+	1
1	EC50 = 3120 nM Bioactivity Info	TI LI LO TS
CP0003418 Compound Info	N-[5-(4-methoxyphenyl)-4-methyl-1H-pyrazol-3-yl]-5-piperidin-1-ylpentanamide Show/Hide	C21H30N4O2	1
1	EC50 = 3160 nM Bioactivity Info	TI LI LO TS
CP0510444 Compound Info	5-[Methyl-(2-pyridin-2-ylethyl)amino]pentanoic acid(4-pyridin-3-yl-phenyl)amide Show/Hide	C24H28N4O	1
1	EC50 = 3270 nM Bioactivity Info	TI LI LO TS
CP0013408 Compound Info	N-[(2S,3R)-2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]octan-3-yl]pyridine-3-carboxamide Show/Hide	C19H22N4O	1
1	EC50 = 3300 nM Bioactivity Info	TI LI LO TS
CP0011421 Compound Info	5-(4-acetyl-1,4-diazepan-1-yl)-N-[5-(4-methoxyphenyl)-1H-imidazol-2-yl]pentanamide Show/Hide	C22H31N5O3	1
1	EC50 = 3470 nM Bioactivity Info	TI LI LO TS
CP0001529 Compound Info	5-(4-Methylpiperazin-1-yl)pentanoic acid(4-pyridin-3-ylphenyl)amide Show/Hide	C21H28N4O	1
1	EC50 = 3560 nM Bioactivity Info	TI LI LO TS
CP0013414 Compound Info	6-chloro-N-[(2S,3R)-2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]octan-3-yl]pyridine-2-carboxamide Show/Hide	C19H21ClN4O	1
1	EC50 = 4100 nM Bioactivity Info	TI LI LO TS
CP0009924 Compound Info	N-[5-(furan-2-yl)-1H-pyrazol-3-yl]-5-piperidin-1-ylpentanamide Show/Hide	C17H24N4O2	1
1	EC50 = 4180 nM Bioactivity Info	TI LI LO TS
CP0009258 Compound Info	N-[(2S,3R)-2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]octan-3-yl]pyridine-4-carboxamide Show/Hide	C19H22N4O	1
1	EC50 = 4800 nM Bioactivity Info	TI LI LO TS
CP0469530 Compound Info	5-Piperidin-1-yl-pentanoic acid quinolin-6-ylamide Show/Hide	C25H29N3O	1
1	EC50 = 5070 nM Bioactivity Info	TI LI LO TS
CP0003698 Compound Info	5-(1,4-diazepan-1-yl)-N-[5-(4-methoxyphenyl)-1H-pyrazol-3-yl]pentanamide Show/Hide	C20H29N5O2	1
1	EC50 = 5410 nM Bioactivity Info	TI LI LO TS
CP0492275 Compound Info	2'-Methylbiphenyl-4-carboxylic acid{4-[4-(2,4-dimethoxyphenyl)piperazin-1-yl]butyl}amide Show/Hide	C30H37N3O3	1
1	EC50 = 5770 nM Bioactivity Info	TI LI LO TS
CP0492276 Compound Info	2'-Fluoro-biphenyl-4-carboxylic acid{4-[4-(2,4-dimethoxy-phenyl)-piperazin-1-yl]-butyl}-amide Show/Hide	C29H34FN3O3	1
1	EC50 = 6030 nM Bioactivity Info	TI LI LO TS
CP0012123 Compound Info	5-piperidin-1-yl-N-(5-pyridin-4-yl-1H-pyrazol-3-yl)pentanamide Show/Hide	C18H25N5O	1
1	EC50 = 6220 nM Bioactivity Info	TI LI LO TS
CP0011185 Compound Info	N-[5-(4-methoxyphenyl)-1H-pyrazol-3-yl]-4-morpholin-4-ylbutanamide Show/Hide	C18H24N4O3	1
1	EC50 = 6606.93 nM Bioactivity Info	TI LI LO TS
CP0010007 Compound Info	5-(4-acetyl-1,4-diazepan-1-yl)-N-[5-(4-methoxyphenyl)-4-methyl-1H-pyrazol-3-yl]pentanamide Show/Hide	C23H33N5O3	1
1	EC50 = 6830 nM Bioactivity Info	TI LI LO TS
CP0010517 Compound Info	2,4-dichloro-N-[(2S,3R)-2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]octan-3-yl]benzamide Show/Hide	C20H21Cl2N3O	1
1	EC50 = 7100 nM Bioactivity Info	TI LI LO TS
CP0011141 Compound Info	7-chloro-3-methyl-N-[(2S,3R)-2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]octan-3-yl]-1-benzofuran-2-carboxamide Show/Hide	C23H24ClN3O2	1
1	EC50 = 8200 nM Bioactivity Info	TI LI LO TS
CP0413816 Compound Info	3-(4-acetyl-1,4-diazepan-1-yl)-N-[5-(4-methoxyphenyl)-1H-pyrazol-3-yl]propanamide Show/Hide	C20H27N5O3	1
1	EC50 = 8511.38 nM Bioactivity Info	TI LI LO TS
CP0538646 Compound Info	2-[(3-chlorophenoxy)methyl]-1-[3-(4-methylpiperazin-1-yl)propyl]benzimidazole Show/Hide	C22H27ClN4O	1
1	EC50 = 10000 nM Bioactivity Info	TI LI LO TS
CP0009433 Compound Info	5-phenyl-N-[(2S,3R)-2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]octan-3-yl]-1,2-oxazole-3-carboxamide Show/Hide	C23H24N4O2	1
1	EC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0010515 Compound Info	N-[(2S,3R)-2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]octan-3-yl]-1,2-oxazole-3-carboxamide Show/Hide	C17H20N4O2	1
1	EC50 = 10000 nM Bioactivity Info	TI LI LO TS
CP0120535 Compound Info	N-[5-(5-fluoropyridin-3-yl)-1H-pyrazol-3-yl]-4-piperidin-1-ylbutanamide Show/Hide	C17H22FN5O	1
1	EC50 = 10700 nM Bioactivity Info	TI LI LO TS
CP0541493 Compound Info	5-Piperidin-1-yl-pentanoic acid benzo[1,3]dioxol-5-ylamide Show/Hide	C23H28N2O3	1
1	EC50 = 10930 nM Bioactivity Info	TI LI LO TS
CP0011144 Compound Info	5-methyl-N-[(2S,3R)-2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]octan-3-yl]furan-2-carboxamide Show/Hide	C19H23N3O2	1
1	EC50 = 11000 nM Bioactivity Info	TI LI LO TS
CP0012972 Compound Info	1-[5-[[5-(4-methoxyphenyl)-1H-pyrazol-3-yl]amino]-5-oxopentyl]piperidine-4-carboxamide Show/Hide	C21H29N5O3	1
1	EC50 = 22240 nM Bioactivity Info	TI LI LO TS
CP0430922 Compound Info	1-[4-(4-Pyridin-3-ylphenylcarbamoyl)butyl]piperidine-3-carboxylic acid diethylamide Show/Hide	C26H36N4O2	1
1	EC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0431000 Compound Info	4-Nitro-N-{4-[4-(2,4-dimethoxyphenyl)piperazin-1-yl]butyl}benzamide Show/Hide	C23H30N4O5	1
1	EC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0439257 Compound Info	5-Piperidin-1-yl-pentanoic acid m-tolylamide Show/Hide	C17H26N2O	1
1	EC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0492274 Compound Info	Biphenyl-4-carboxylic acid{4-[4-(2,4-dimethoxyphenyl)-piperazin-1-yl]-butyl}amide Show/Hide	C29H35N3O3	1
1	EC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0510405 Compound Info	4-Bromo-N-{4-[4-(2,4-dimethoxyphenyl)piperazin-1-yl]butyl}benzamide Show/Hide	C23H30BrN3O3	1
1	EC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0011961 Compound Info	N-[5-(4-methoxyphenyl)-1H-pyrazol-3-yl]-5-(3-oxopiperazin-1-yl)pentanamide Show/Hide	C19H25N5O3	1
1	EC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0012031 Compound Info	N-[5-(4-methoxyphenyl)-1H-pyrazol-3-yl]-5-(5-oxo-1,4-diazepan-1-yl)pentanamide Show/Hide	C20H27N5O3	1
1	EC50 > 30000 nM Bioactivity Info	TI LI LO TS
CP0011184 Compound Info	N-(5-tert-butyl-1H-pyrazol-3-yl)-4-piperidin-1-ylbutanamide Show/Hide	C16H28N4O	1
1	EC50 > 31622.78 nM Bioactivity Info	TI LI LO TS
CP0237924 Compound Info	4-(6-Chlorooxazolo[4,5-b]pyridin-2-yl)-1,4-diazabicyclo[3.2.2]-nonane Show/Hide	C13H15ClN4O	1
1	Ki = 1 nM Bioactivity Info	TI LI LO TS
CP0476149 Compound Info	2-(1,4-Diazabicyclo[3.2.2]nonan-4-yl)-5-(pyrrolidin-1-yl)oxazolo-[4,5-b]pyridine Show/Hide	C17H23N5O	1
1	Ki = 1.91 nM Bioactivity Info	TI LI LO TS
CP0447804 Compound Info	4-(5-Chlorobenzoxazol-2-yl)-1,4-diazabicyclo[3.2.2]nonane Show/Hide	C14H16ClN3O	1
1	Ki = 1.92 nM Bioactivity Info	TI LI LO TS
CP0060566 Compound Info	4-(6-Bromooxazolo[4,5-b]pyridin-2-yl)-1,4-diazabicyclo[3.2.2]-nonane Show/Hide	C13H15BrN4O	1
1	Ki = 2.08 nM Bioactivity Info	TI LI LO TS
CP0371836 Compound Info	4-(5-Bromobenzoxazol-2-yl)-1,4-diazabicyclo[3.2.2]nonane Show/Hide	C14H16BrN3O	1
1	Ki = 2.15 nM Bioactivity Info	TI LI LO TS
CP0371827 Compound Info	4-(6-Phenyloxazolo[5,4-b]pyridin-2-yl)-1,4-diazabicyclo[3.2.2]-nonane Show/Hide	C19H20N4O	1
1	Ki = 2.31 nM Bioactivity Info	TI LI LO TS
CP0342728 Compound Info	2-(6-Chlorooxazolo[5,4-b]pyridin-2-yl)-2,5-diazabicyclo[3.2.2]-nonane Show/Hide	C13H15ClN4O	1
1	Ki = 2.59 nM Bioactivity Info	TI LI LO TS
CP0080669 Compound Info	4-(6-Chloro-5-methyloxazolo[4,5-b]pyridin-2-yl)-1,4-diazabicyclo-[3.2.2]nonane Show/Hide	C14H17ClN4O	1
1	Ki = 3.19 nM Bioactivity Info	TI LI LO TS
CP0371832 Compound Info	2-(5-Phenyloxazolo[4,5-b]pyridin-2-yl)-2,5-diazabicyclo[3.2.2]-nonane Show/Hide	C19H20N4O	1
1	Ki = 3.22 nM Bioactivity Info	TI LI LO TS
CP0034957 Compound Info	2-(5-(2-Fluorophenyl)oxazolo[4,5-b]pyridin-2-yl)-2,5-diazabicyclo[3.2.2]nonane Show/Hide	C19H19FN4O	1
1	Ki = 3.45 nM Bioactivity Info	TI LI LO TS
CP0447806 Compound Info	2-(6-Phenoxyoxazolo[4,5-b]pyridin-2-yl)-2,5-diazabicyclo[3.2.2]-nonane Show/Hide	C19H20N4O2	1
1	Ki = 4.16 nM Bioactivity Info	TI LI LO TS
CP0387208 Compound Info	2-(5-Cyclopentyloxazolo[4,5-b]pyridin-2-yl)-2,5-diazabicyclo-[3.2.2]nonane Show/Hide	C18H24N4O	1
1	Ki = 5.3 nM Bioactivity Info	TI LI LO TS
CP0476148 Compound Info	4-(6-Cyanooxazolo[4,5-b]pyridin-2-yl)-1,4-diazabicyclo[3.2.2]-nonane Show/Hide	C14H15N5O	1
1	Ki = 6.2 nM Bioactivity Info	TI LI LO TS
CP0481485 Compound Info	4-(6-Methyloxazolo[4,5-b]pyridin-2-yl)-1,4-diazabicyclo[3.2.2]-nonane Show/Hide	C14H18N4O	1
1	Ki = 6.66 nM Bioactivity Info	TI LI LO TS
CP0447805 Compound Info	4-(6-Phenyloxazolo[4,5-b]pyridin-2-yl)-1,4-diazabicyclo[3.2.2]-nonane Show/Hide	C19H20N4O	1
1	Ki = 7.04 nM Bioactivity Info	TI LI LO TS
CP0460434 Compound Info	(3-phenylphenyl) 1,4-diazabicyclo[3.2.2]nonane-4-carboxylate Show/Hide	C20H22N2O2	1
1	Ki = 9 nM Bioactivity Info	TI LI LO TS
CP0459022 Compound Info	2-(5-Isopropyloxazolo[4,5-b]pyridin-2-yl)-2,5-diazabicyclo[3.2.2]-nonane Show/Hide	C16H22N4O	1
1	Ki = 9.05 nM Bioactivity Info	TI LI LO TS
CP0407566 Compound Info	3-bromophenyl 1,4-diazabicyclo[3.2.2]nonane-4-carboxylate Show/Hide	C14H17BrN2O2	1
1	Ki = 9.5 nM Bioactivity Info	TI LI LO TS
CP0398405 Compound Info	3-benzoylphenyl 1,4-diazabicyclo[3.2.2]nonane-4-carboxylate Show/Hide	C21H22N2O3	1
1	Ki = 11 nM Bioactivity Info	TI LI LO TS
CP0503929 Compound Info	3-phenoxyphenyl 1,4-diazabicyclo[3.2.2]nonane-4-carboxylate Show/Hide	C20H22N2O3	1
1	Ki = 13 nM Bioactivity Info	TI LI LO TS
CP0007707 Compound Info	4-(5-Methyloxazolo[4,5-b]pyridin-2-yl)-1,4-diazabicyclo[3.2.2]-nonane Show/Hide	C14H18N4O	1
1	Ki = 13.5 nM Bioactivity Info	TI LI LO TS
CP0371831 Compound Info	4-(6-Fluoro-5-methyloxazolo[4,5-b]pyridin-2-yl)-1,4-diazabicyclo[3.2.2]nonane Show/Hide	C14H17FN4O	1
1	Ki = 15.3 nM Bioactivity Info	TI LI LO TS
CP0496691 Compound Info	3-benzoyl-4-bromophenyl 1,4-diazabicyclo[3.2.2]nonane-4-carboxylate Show/Hide	C21H21BrN2O3	1
1	Ki = 16 nM Bioactivity Info	TI LI LO TS
CP0237925 Compound Info	4-(6-Fluorooxazolo[4,5-b]pyridin-2-yl)-1,4-diazabicyclo[3.2.2]-nonane Show/Hide	C13H15FN4O	1
1	Ki = 17.2 nM Bioactivity Info	TI LI LO TS
CP0371835 Compound Info	2-(5-Phenoxyoxazolo[4,5-b]pyridin-2-yl)-2,5-diazabicyclo[3.2.2]-nonane Show/Hide	C19H20N4O2	1
1	Ki = 17.3 nM Bioactivity Info	TI LI LO TS
CP0421783 Compound Info	4-(6-Methylbenzoxazol-2-yl)-1,4-diazabicyclo[3.2.2]nonane Show/Hide	C15H19N3O	1
1	Ki = 17.9 nM Bioactivity Info	TI LI LO TS
CP0135869 Compound Info	2-(5-Ethyloxazolo[4,5-b]pyridin-2-yl)-2,5-diazabicyclo[3.2.2]-nonane Show/Hide	C15H20N4O	1
1	Ki = 18.7 nM Bioactivity Info	TI LI LO TS
CP0421782 Compound Info	4-(5-Fluorobenzoxazol-2-yl)-1,4-diazabicyclo[3.2.2]nonane Show/Hide	C14H16FN3O	1
1	Ki = 20.7 nM Bioactivity Info	TI LI LO TS
CP0197608 Compound Info	4-Benzoxazo-2-yl-1,4-diazabicyclo[3.2.2]nonane Show/Hide	C14H17N3O	1
1	Ki = 22.5 nM Bioactivity Info	TI LI LO TS
CP0488651 Compound Info	4-(6-Ethyloxazolo[4,5-b]pyridin-2-yl)-1,4-diazabicyclo[3.2.2]-nonane Show/Hide	C15H20N4O	1
1	Ki = 22.5 nM Bioactivity Info	TI LI LO TS
CP0473866 Compound Info	naphthalen-2-yl 1,4-diazabicyclo[3.2.2]nonane-4-carboxylate Show/Hide	C18H20N2O2	1
1	Ki = 23 nM Bioactivity Info	TI LI LO TS
CP0459021 Compound Info	2-(6-(1H-Pyrazol-3-yl)oxazolo[4,5-b]pyridin-2-yl)-2,5-diazabicyclo[3.2.2]nonane Show/Hide	C16H18N6O	1
1	Ki = 23 nM Bioactivity Info	TI LI LO TS
CP0382768 Compound Info	2-(5-Methoxyoxazolo[4,5-b]pyridin-2-yl)-2,5-diazabicyclo[3.2.2]-nonane Show/Hide	C14H18N4O2	1
1	Ki = 24.9 nM Bioactivity Info	TI LI LO TS
CP0457487 Compound Info	(3-methylphenyl) 1,4-diazabicyclo[3.2.2]nonane-4-carboxylate Show/Hide	C15H20N2O2	1
1	Ki = 25 nM Bioactivity Info	TI LI LO TS
CP0191832 Compound Info	4-Oxazolo[4,5-b]pyridin-2-yl-1,4-diazabicyclo[3.2.2]nonane Show/Hide	C13H16N4O	1
1	Ki = 30.3 nM Bioactivity Info	TI LI LO TS
CP0396962 Compound Info	3,4-dichlorophenyl 1,4-diazabicyclo[3.2.2]nonane-4-carboxylate Show/Hide	C14H16Cl2N2O2	1
1	Ki = 31 nM Bioactivity Info	TI LI LO TS
CP0397017 Compound Info	3-chlorophenyl 1,4-diazabicyclo[3.2.2]nonane-4-carboxylate Show/Hide	C14H17ClN2O2	1
1	Ki = 32 nM Bioactivity Info	TI LI LO TS
CP0460435 Compound Info	4-bromo-3-chlorophenyl 1,4-diazabicyclo[3.2.2]nonane-4-carboxylate Show/Hide	C14H16BrClN2O2	1
1	Ki = 33 nM Bioactivity Info	TI LI LO TS
CP0376721 Compound Info	4-(5-Methylbenzoxazol-2-yl)-1,4-diazabicyclo[3.2.2]nonane Show/Hide	C15H19N3O	1
1	Ki = 33.6 nM Bioactivity Info	TI LI LO TS
CP0407568 Compound Info	3-fluorophenyl 1,4-diazabicyclo[3.2.2]nonane-4-carboxylate Show/Hide	C14H17FN2O2	1
1	Ki = 35 nM Bioactivity Info	TI LI LO TS
CP0047123 Compound Info	1,4-diazabicyclo[3.2.2]nonane-(4-bromo)-phenyl carbamate Show/Hide	C14H17BrN2O2	1
1	Ki = 38 nM Bioactivity Info	TI LI LO TS
CP0459024 Compound Info	4-Oxazolo[5,4-b]pyridin-2-yl-1,4-diazabicyclo[3.2.2]nonane Show/Hide	C13H16N4O	1
1	Ki = 40.6 nM Bioactivity Info	TI LI LO TS
CP0398406 Compound Info	4-bromo-3-methylphenyl 1,4-diazabicyclo[3.2.2]nonane-4-carboxylate Show/Hide	C15H19BrN2O2	1
1	Ki = 50 nM Bioactivity Info	TI LI LO TS
CP0371830 Compound Info	2-(6-(Pyrimidine-5-yl)oxazolo[4,5-b]pyridin-2-yl)-2,5-diazabicyclo[3.2.2]nonane Show/Hide	C17H18N6O	1
1	Ki = 60 nM Bioactivity Info	TI LI LO TS
CP0488652 Compound Info	2-(5-(Piperidin-1-yl)oxazolo[4,5-b]pyridin-2-yl)-2,5-diazabicyclo-[3.2.2]nonane Show/Hide	C18H25N5O	1
1	Ki = 67.1 nM Bioactivity Info	TI LI LO TS
CP0407567 Compound Info	4-chlorophenyl 1,4-diazabicyclo[3.2.2]nonane-4-carboxylate Show/Hide	C14H17ClN2O2	1
1	Ki = 79 nM Bioactivity Info	TI LI LO TS
CP0473864 Compound Info	3-methoxyphenyl 1,4-diazabicyclo[3.2.2]nonane-4-carboxylate Show/Hide	C15H20N2O3	1
1	Ki = 79 nM Bioactivity Info	TI LI LO TS
CP0503928 Compound Info	4-chloro-3-fluorophenyl 1,4-diazabicyclo[3.2.2]nonane-4-carboxylate Show/Hide	C14H16ClFN2O2	1
1	Ki = 86 nM Bioactivity Info	TI LI LO TS
CP0459020 Compound Info	2-(5-Methyloxazolo[5,4-b]pyridin-2-yl)-2,5-diazabicyclo[3.2.2]-nonane Show/Hide	C14H18N4O	1
1	Ki = 88.6 nM Bioactivity Info	TI LI LO TS
CP0460429 Compound Info	4-benzoylphenyl 1,4-diazabicyclo[3.2.2]nonane-4-carboxylate Show/Hide	C21H22N2O3	1
1	Ki = 95 nM Bioactivity Info	TI LI LO TS
CP0371829 Compound Info	2-(6-(Pyridin-3-yl)oxazolo[4,5-b]pyridin-2-yl)-2,5-diazabicyclo-[3.2.2]nonane Show/Hide	C18H19N5O	1
1	Ki = 119 nM Bioactivity Info	TI LI LO TS
CP0388076 Compound Info	1-azabicyclo[2.2.1]heptan-3-yl N-(4-bromophenyl)carbamate Show/Hide	C13H15BrN2O2	1
1	Ki = 167 nM Bioactivity Info	TI LI LO TS
CP0407565 Compound Info	(4-methylphenyl) 1,4-diazabicyclo[3.2.2]nonane-4-carboxylate Show/Hide	C15H20N2O2	1
1	Ki = 178 nM Bioactivity Info	TI LI LO TS
CP0496706 Compound Info	4-methoxyphenyl 1,4-diazabicyclo[3.2.2]nonane-4-carboxylate Show/Hide	C15H20N2O3	1
1	Ki = 201 nM Bioactivity Info	TI LI LO TS
CP0460433 Compound Info	4-(pyridin-3-yl)phenyl 1,4-diazabicyclo[3.2.2]nonane-4-carboxylate Show/Hide	C19H21N3O2	1
1	Ki = 203 nM Bioactivity Info	TI LI LO TS
CP0506294 Compound Info	4-(pyridin-4-yl)phenyl 1,4-diazabicyclo[3.2.2]nonane-4-carboxylate Show/Hide	C19H21N3O2	1
1	Ki = 207 nM Bioactivity Info	TI LI LO TS
CP0503930 Compound Info	4-phenoxyphenyl 1,4-diazabicyclo[3.2.2]nonane-4-carboxylate Show/Hide	C20H22N2O3	1
1	Ki = 212 nM Bioactivity Info	TI LI LO TS
CP0473750 Compound Info	(4-phenylphenyl) 1,4-diazabicyclo[3.2.2]nonane-4-carboxylate Show/Hide	C20H22N2O2	1
1	Ki = 215 nM Bioactivity Info	TI LI LO TS
CP0382769 Compound Info	4-Oxazolo[5,4-c]pyridin-2-yl-1,4-diazabicyclo[3.2.2]nonane Show/Hide	C13H16N4O	1
1	Ki = 309 nM Bioactivity Info	TI LI LO TS
CP0421784 Compound Info	4-Oxazolo[4,5-c]pyridin-2-yl-1,4-diazabicyclo[3.2.2]nonane Show/Hide	C13H16N4O	1
1	Ki = 312 nM Bioactivity Info	TI LI LO TS
CP0636607 Compound Info	5,8,14-triazatetracyclo[10.3.1.02,11.04,9]hexadeca-2(11),3,5,7,9-pentaene dihydrochloride Show/Hide	C13H15Cl2N3	1
1	Ki = 322 nM Bioactivity Info	TI LI LO TS
CP0397020 Compound Info	N-(4-bromophenyl)-1,4-diazabicyclo[3.2.2]nonane-4-carboxamide Show/Hide	C14H18BrN3O	1
1	Ki = 328 nM Bioactivity Info	TI LI LO TS
CP0496705 Compound Info	4-(pyridin-2-yl)phenyl 1,4-diazabicyclo[3.2.2]nonane-4-carboxylate Show/Hide	C19H21N3O2	1
1	Ki = 354 nM Bioactivity Info	TI LI LO TS
CP0398397 Compound Info	1,5-diazabicyclo[4.2.2]decane carbamate Show/Hide	C15H19BrN2O2	1
1	Ki = 383 nM Bioactivity Info	TI LI LO TS
CP0407569 Compound Info	4-fluorophenyl 1,4-diazabicyclo[3.2.2]nonane-4-carboxylate Show/Hide	C14H17FN2O2	1
1	Ki = 537 nM Bioactivity Info	TI LI LO TS
CP0498375 Compound Info	2-bromophenyl 1,4-diazabicyclo[3.2.2]nonane-4-carboxylate Show/Hide	C14H17BrN2O2	1
1	Ki = 725 nM Bioactivity Info	TI LI LO TS
CP0080659 Compound Info	phenyl 1,4-diazabicyclo[3.2.2]nonane-4-carboxylate Show/Hide	C14H18N2O2	1
1	Ki = 739 nM Bioactivity Info	TI LI LO TS
CP0397019 Compound Info	O-phenyl 1,4-diazabicyclo[3.2.2]nonane-4-carbothioate Show/Hide	C14H18N2OS	1
1	Ki = 749 nM Bioactivity Info	TI LI LO TS
CP0398403 Compound Info	1,4-diazabicyclo[4.2.2]decanecarbamate Show/Hide	C15H19BrN2O2	1
1	Ki = 763 nM Bioactivity Info	TI LI LO TS
CP0407571 Compound Info	2-chlorophenyl 1,4-diazabicyclo[3.2.2]nonane-4-carboxylate Show/Hide	C14H17ClN2O2	1
1	Ki = 868 nM Bioactivity Info	TI LI LO TS
CP0398401 Compound Info	benzyl 1,4-diazabicyclo[3.2.2]nonane-4-carboxylate Show/Hide	C15H20N2O2	1
1	Ki = 3350 nM Bioactivity Info	TI LI LO TS
CP0633428 Compound Info	SID56463106 Show/Hide	C11H14N2O	1
1	Ki = 4200 nM Bioactivity Info	TI LI LO TS
CP0637154 Compound Info	4-nitro-10-azatricyclo[6.3.1.02,7]dodeca-2(7),3,5-triene hydrochloride Show/Hide	C11H13ClN2O2	1
1	Ki = 7340 nM Bioactivity Info	TI LI LO TS
CP0510864 Compound Info	4-(6-sec-Butyloxazolo[4,5-b]pyridin-2-yl)-1,4-diazabicyclo[3.2.2]-nonane Show/Hide	C17H24N4O	1
1	Ki > 1000 nM Bioactivity Info	TI LI LO TS
CP0498376 Compound Info	4-(4-bromophenylsulfonyl)-1,4-diazabicyclo[3.2.2]nonane Show/Hide	C13H17BrN2O2S	1
1	Ki > 4720 nM Bioactivity Info	TI LI LO TS
CP0001752 Compound Info	10-Aza-tricyclo[6.3.1.02,7]dodeca-2(7),3,5-triene Show/Hide	C11H13N	1
1	Ki > 5000 nM Bioactivity Info	TI LI LO TS
CP0388075 Compound Info	(2S,5R)-4-bromophenyl 2,5-dimethylpiperazine-1-carboxylate Show/Hide	C13H17BrN2O2	1
1	Ki > 5000 nM Bioactivity Info	TI LI LO TS
CP0407570 Compound Info	(R)-4-bromophenyl 3-methylpiperazine-1-carboxylate Show/Hide	C12H15BrN2O2	1
1	Ki > 5000 nM Bioactivity Info	TI LI LO TS
CP0407572 Compound Info	(3S,5R)-4-bromophenyl 3,5-dimethylpiperazine-1-carboxylate Show/Hide	C13H17BrN2O2	1
1	Ki > 5000 nM Bioactivity Info	TI LI LO TS
CP0498374 Compound Info	1-(1,4-diazabicyclo[3.2.2]nonan-4-yl)-2-(4-bromophenyl)ethanone Show/Hide	C15H19BrN2O	1
1	Ki > 5000 nM Bioactivity Info	TI LI LO TS
CP0398402 Compound Info	1-(4-bromophenyl)-4-methyl-1,4-diazepane-1-carboxylate Show/Hide	C13H17BrN2O2	1
1	Ki > 5710 nM Bioactivity Info	TI LI LO TS

Cell Line ID: CL000006 , HEK293

Cell Line Info

Cell Line ID: CL000028 , PC-12

Cell Line Info

Cell Line ID: CL000868 , PC12

Cell Line Info

Biochemical Assays

Compound ID	Compound Name	Compound Formula
CP0000063 Compound Info	CAS_29790-52-1 Show/Hide	C10H14N2	4
1	EC50 = 13000 nM
2	EC50 = 47000 nM
3	Ki = 400 nM
4	Ki = 610 nM
CP0045981 Compound Info	(S)-3-(Benzo[b]thiophen-2-ylmethoxy)-1-aza-bicyclo[2.2.2]octane Show/Hide	C16H19NOS	1
1	Ki = 13 nM
CP0047123 Compound Info	1,4-diazabicyclo[3.2.2]nonane-(4-bromo)-phenyl carbamate Show/Hide	C14H17BrN2O2	1
1	Ki = 22 nM
CP0000457 Compound Info	5,8,14-triazatetracyclo[10.3.1.02,11.04,9]hexadeca-2(11),3,5,7,9-pentaene; dihydrochloride Show/Hide	C13H13N3	1
1	Ki = 125 nM
CP0633428 Compound Info	SID56463106 Show/Hide	C11H14N2O	2
1	Ki = 1700 nM
2	Ki = 8000 nM

Similar Protein(s) and Bioactivity Statistics

90% Identity

Protein ID	Protein Name	Protein Organism
PT01846	Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens, Human	Protein Info

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han