General Information of the Compound
Compound ID
CP0473866
Compound Name
naphthalen-2-yl 1,4-diazabicyclo[3.2.2]nonane-4-carboxylate
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Structure
Formula
C18H20N2O2
Molecular Weight
296.37
Canonical SMILES
O=C(Oc1ccc2ccccc2c1)N1CCN2CCC1CC2
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InChI
InChI=1S/C18H20N2O2/c21-18(20-12-11-19-9-7-16(20)8-10-19)22-17-6-5-14-3-1-2-4-15(14)13-17/h1-6,13,16H,7-12H2
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InChIKey
MQZFLDZRBIKMGM-UHFFFAOYSA-N
Physicochemical Property
logP
3.1186
Rotatable Bonds
1
Heavy Atom Count
22
Polar Areas
32.78
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
3
Complexity
22

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 9879256
SID: 14845290
ChEMBL ID
CHEMBL564850
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02227, 5-hydroxytryptamine receptor 3A
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 > 3160 nM
   TI
   LI
   LO
   TS
Protein ID: PT02515, Neuronal acetylcholine receptor subunit alpha-3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000016 IMR-32 Homo sapiens (Human)  1
1
IC50 = 4910 nM
   TI
   LI
   LO
   TS
Protein ID: PT02118, Neuronal acetylcholine receptor subunit alpha-7
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000029 GH4C1 Rattus norvegicus (Rat)  1
1
Ki = 23 nM
   TI
   LI
   LO
   TS