General Information of the Compound
Compound ID
CP0011174
Compound Name
3-fluoro-4-hydroxy-N-[(2S,3R)-2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]octan-3-yl]benzamide
    Show/Hide
Structure
Formula
C20H22FN3O2
Molecular Weight
355.413
Canonical SMILES
Oc1ccc(cc1F)C(=O)N[C@@H]1C2CCN(CC2)[C@H]1Cc1cccnc1
    Show/Hide
InChI
InChI=1S/C20H22FN3O2/c21-16-11-15(3-4-18(16)25)20(26)23-19-14-5-8-24(9-6-14)17(19)10-13-2-1-7-22-12-13/h1-4,7,11-12,14,17,19,25H,5-6,8-10H2,(H,23,26)/t17-,19+/m0/s1
    Show/Hide
InChIKey
RWGCYZQZMFBNFU-PKOBYXMFSA-N
Physicochemical Property
logP
2.3616
Rotatable Bonds
4
Heavy Atom Count
26
Polar Areas
65.46
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
4
Complexity
26

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 71453796
SID: 163505289
ChEMBL ID
CHEMBL2179847
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02118, Neuronal acetylcholine receptor subunit alpha-7
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000029 GH4C1 Rattus norvegicus (Rat)  1
1
EC50 = 1700 nM
   TI
   LI
   LO
   TS
Protein ID: PT01846, Neuronal acetylcholine receptor subunit alpha-7
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 52.5 nM
   TI
   LI
   LO
   TS