General Information of the Protein
Protein ID
PT01846
Protein Name
Neuronal acetylcholine receptor subunit alpha-7
Gene Name
CHRNA7
Secondarily
Gene Name
NACHRA7
Sequence
MRCSPGGVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
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Organism
Homo sapiens, Human
Protein Classification
Ion channel
>
Ligand-gated ion channel
>
Nicotinic acetylcholine receptor
>
Nicotinic acetylcholine receptor alpha subunit
Function
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin.
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Uniprot ID
Primary ID:
P36544

Secondarily ID:
A8K7Q4
B4DFS0
Q15826
Q8IUZ4
Q96RH2
Q99555
Q9BXH0
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Ensembl ID
ENSG00000175344
HGNC ID
HGNC:1960
Subcellular Location
Postsynaptic cell membrane
Cell membrane
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000011 , CHO
Compound ID Compound Name Compound Formula
CP0011420
5-(4-acetyl-1,4-diazepan-1-yl)-N-[5-(4-methoxyphenyl)-1H-pyrazol-3-yl]pentanamide
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C22H31N5O3
 1
1
EC50 = 3000 nM
   TI
   LI
   LO
   TS
CP0005767
3,7-diazabicyclo[3.3.1]nonan-3-yl-[(1S,2R)-2-methylcyclopropyl]methanone
   Show/Hide
C12H20N2O
 1
1
Ki = 5 nM
   TI
   LI
   LO
   TS
CP0000360
3,7-diazabicyclo[3.3.1]nonan-3-yl-[(1S,2R)-2-fluorocyclopropyl]methanone
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C11H17FN2O
 1
1
Ki = 10 nM
   TI
   LI
   LO
   TS
CP0003306
cyclopropyl(3,7-diazabicyclo[3.3.1]nonan-3-yl)methanone
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C11H18N2O
 1
1
Ki = 20 nM
   TI
   LI
   LO
   TS
CP0000331
3,7-diazabicyclo[3.3.1]nonan-3-yl-[(1R,2R)-2-methylcyclopropyl]methanone
   Show/Hide
C12H20N2O
 1
1
Ki = 30 nM
   TI
   LI
   LO
   TS
CP0000919
cyclopropyl-[(1R,5S)-3,6-diazabicyclo[3.2.1]octan-3-yl]methanone
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C10H16N2O
 1
1
Ki = 40 nM
   TI
   LI
   LO
   TS
CP0000353
3,7-diazabicyclo[3.3.1]nonan-3-yl-[(1R,2S)-2-methylcyclopropyl]methanone
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C12H20N2O
 1
1
Ki = 100 nM
   TI
   LI
   LO
   TS
CP0001415
3,7-diazabicyclo[3.3.1]nonan-3-yl-[(1R,2R)-2-fluorocyclopropyl]methanone
   Show/Hide
C11H17FN2O
 1
1
Ki = 100 nM
   TI
   LI
   LO
   TS
CP0006775
[(3aR,6aS)-1,2,3,3a,4,5,6,6a-octahydrocyclopenta[c]pyrrol-5-yl]-cyclopropylmethanone
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C11H17NO
 1
1
Ki = 140 nM
   TI
   LI
   LO
   TS
CP0009419
cyclopropyl-[(1S,5R)-3,6-diazabicyclo[3.2.1]octan-3-yl]methanone
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C10H16N2O
 1
1
Ki = 210 nM
   TI
   LI
   LO
   TS
CP0002644
3,7-diazabicyclo[3.3.1]nonan-3-yl-[(1S,2S)-2-methylcyclopropyl]methanone
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C12H20N2O
 1
1
Ki = 300 nM
   TI
   LI
   LO
   TS
CP0006147
3,7-diazabicyclo[3.3.1]nonan-3-yl-[(1S,2S)-2-fluorocyclopropyl]methanone
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C11H17FN2O
 1
1
Ki = 300 nM
   TI
   LI
   LO
   TS
CP0633535
3-(Cyclopropylcarbonyl)-3,6-diazabicyclo[3.2.1]octane
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C10H16N2O
 1
1
Ki = 350 nM
   TI
   LI
   LO
   TS
CP0001419
2,3,3a,4,6,6a-hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl-[(1S,2R)-2-methylcyclopropyl]methanone
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C11H18N2O
 1
1
Ki = 350 nM
   TI
   LI
   LO
   TS
CP0000356
3,7-diazabicyclo[3.3.1]nonan-3-yl-[(1R,2S)-2-fluorocyclopropyl]methanone
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C11H17FN2O
 1
1
Ki = 400 nM
   TI
   LI
   LO
   TS
CP0002192
[(1R,5S)-3,6-diazabicyclo[3.2.1]octan-3-yl]-(furan-2-yl)methanone
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C11H14N2O2
 1
1
Ki = 560 nM
   TI
   LI
   LO
   TS
CP0001523
2,3,3a,4,6,6a-hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl(cyclopropyl)methanone
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C10H16N2O
 1
1
Ki = 840 nM
   TI
   LI
   LO
   TS
CP0000357
2,3,3a,4,6,6a-hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl-[(1S,2R)-2-fluorocyclopropyl]methanone
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C10H15FN2O
 1
1
Ki = 990 nM
   TI
   LI
   LO
   TS
CP0002199
2,3,3a,4,6,6a-hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl-(5-fluorofuran-2-yl)methanone
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C11H13FN2O2
 1
1
Ki = 1200 nM
   TI
   LI
   LO
   TS
CP0003305
3,6-diazabicyclo[3.2.1]octan-3-yl(pyridin-4-yl)methanone
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C12H15N3O
 1
1
Ki = 1300 nM
   TI
   LI
   LO
   TS
CP0000358
2,3,3a,4,6,6a-hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl-[(1R,2R)-2-fluorocyclopropyl]methanone
   Show/Hide
C10H15FN2O
 1
1
Ki = 1400 nM
   TI
   LI
   LO
   TS
CP0006364
[(1R,5S)-3,6-diazabicyclo[3.2.1]octan-3-yl]-(5-fluorofuran-2-yl)methanone
   Show/Hide
C11H13FN2O2
 1
1
Ki = 1600 nM
   TI
   LI
   LO
   TS
CP0002207
1-(3,7-diazabicyclo[3.3.1]nonan-3-yl)propan-1-one
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C10H18N2O
 1
1
Ki = 1600 nM
   TI
   LI
   LO
   TS
CP0000361
2,3,3a,4,6,6a-hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl-[(1R,2R)-2-methylcyclopropyl]methanone
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C11H18N2O
 1
1
Ki = 1900 nM
   TI
   LI
   LO
   TS
CP0002190
2,3,3a,4,6,6a-hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl-(3-chlorofuran-2-yl)methanone
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C11H13ClN2O2
 1
1
Ki = 2600 nM
   TI
   LI
   LO
   TS
CP0002208
2,3,3a,4,6,6a-hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl-[(1R,2S)-2-fluorocyclopropyl]methanone
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C10H15FN2O
 1
1
Ki = 2700 nM
   TI
   LI
   LO
   TS
CP0000063
CAS_29790-52-1
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C10H14N2
 1
1
Ki = 3000 nM
   TI
   LI
   LO
   TS
CP0002209
1-(3,7-diazabicyclo[3.3.1]nonan-3-yl)ethanone
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C9H16N2O
 1
1
Ki = 3300 nM
   TI
   LI
   LO
   TS
CP0002204
[(3aR,6aS)-1,2,3,3a,4,5,6,6a-octahydrocyclopenta[c]pyrrol-5-yl]-(furan-2-yl)methanone
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C12H15NO2
 1
1
Ki = 3400 nM
   TI
   LI
   LO
   TS
CP0000922
2,3,3a,4,6,6a-hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl-(3-methylfuran-2-yl)methanone
   Show/Hide
C12H16N2O2
 1
1
Ki = 3700 nM
   TI
   LI
   LO
   TS
CP0002206
1-(2,3,3a,4,6,6a-hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl)propan-1-one
   Show/Hide
C9H16N2O
 1
1
Ki = 4000 nM
   TI
   LI
   LO
   TS
CP0002203
2,3,3a,4,6,6a-hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl-[(1R,2S)-2-methylcyclopropyl]methanone
   Show/Hide
C11H18N2O
 1
1
Ki = 4500 nM
   TI
   LI
   LO
   TS
CP0002188
2,3,3a,4,6,6a-hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl-(4-bromofuran-2-yl)methanone
   Show/Hide
C11H13BrN2O2
 1
1
Ki = 4600 nM
   TI
   LI
   LO
   TS
CP0002197
3,7-diazabicyclo[3.3.1]nonan-3-yl-(5-fluorofuran-2-yl)methanone
   Show/Hide
C12H15FN2O2
 1
1
Ki = 4700 nM
   TI
   LI
   LO
   TS
CP0002200
[(1S,5R)-3,6-diazabicyclo[3.2.1]octan-3-yl]-(furan-2-yl)methanone
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C11H14N2O2
 1
1
Ki = 5500 nM
   TI
   LI
   LO
   TS
CP0000921
2,3,3a,4,6,6a-hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl-(4-methyl-1,3-oxazol-5-yl)methanone
   Show/Hide
C11H15N3O2
 1
1
Ki = 5900 nM
   TI
   LI
   LO
   TS
CP0002194
2,3,3a,4,6,6a-hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl(furan-2-yl)methanone
   Show/Hide
C11H14N2O2
 1
1
Ki = 5900 nM
   TI
   LI
   LO
   TS
CP0001522
2,3,3a,4,6,6a-hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl-(3-bromofuran-2-yl)methanone
   Show/Hide
C11H13BrN2O2
 1
1
Ki = 6300 nM
   TI
   LI
   LO
   TS
CP0000348
2,3,3a,4,6,6a-hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl-(5-chlorofuran-2-yl)methanone
   Show/Hide
C11H13ClN2O2
 1
1
Ki = 6700 nM
   TI
   LI
   LO
   TS
CP0002205
2,3,3a,4,6,6a-hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl-[(1S,2S)-2-fluorocyclopropyl]methanone
   Show/Hide
C10H15FN2O
 1
1
Ki = 6900 nM
   TI
   LI
   LO
   TS
CP0001525
2,3,3a,4,6,6a-hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl(1,3-oxazol-5-yl)methanone
   Show/Hide
C10H13N3O2
 1
1
Ki = 7600 nM
   TI
   LI
   LO
   TS
CP0633962
3-(2-Furoyl)-3,6-diazabicyclo[3.2.1]octane
   Show/Hide
C11H14N2O2
 1
1
Ki = 7800 nM
   TI
   LI
   LO
   TS
CP0001674
(5-bromofuran-2-yl)-[(1S,5R)-3,6-diazabicyclo[3.2.1]octan-3-yl]methanone
   Show/Hide
C11H13BrN2O2
 1
1
Ki = 8200 nM
   TI
   LI
   LO
   TS
CP0002183
3,7-diazabicyclo[3.3.1]nonan-3-yl(furan-2-yl)methanone
   Show/Hide
C12H16N2O2
 1
1
Ki = 8200 nM
   TI
   LI
   LO
   TS
CP0002198
2,3,3a,4,6,6a-hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl-(5-methylfuran-2-yl)methanone
   Show/Hide
C12H16N2O2
 1
1
Ki = 8200 nM
   TI
   LI
   LO
   TS
CP0000917
5-(2,3,3a,4,6,6a-hexahydro-1H-pyrrolo[3,4-c]pyrrole-5-carbonyl)furan-3-carbonitrile
   Show/Hide
C12H13N3O2
 1
1
Ki = 8600 nM
   TI
   LI
   LO
   TS
CP0001521
2-(2,3,3a,4,6,6a-hexahydro-1H-pyrrolo[3,4-c]pyrrole-5-carbonyl)furan-3-carbonitrile
   Show/Hide
C12H13N3O2
 1
1
Ki = 8800 nM
   TI
   LI
   LO
   TS
CP0000896
3,7-diazabicyclo[3.3.1]nonan-3-yl-(3-fluorofuran-2-yl)methanone
   Show/Hide
C12H15FN2O2
 1
1
Ki > 10000 nM
   TI
   LI
   LO
   TS
CP0000918
2,3,3a,4,6,6a-hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl-(4-chlorofuran-2-yl)methanone
   Show/Hide
C11H13ClN2O2
 1
1
Ki > 10000 nM
   TI
   LI
   LO
   TS
CP0000920
2,3,3a,4,6,6a-hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl-(3-fluorofuran-2-yl)methanone
   Show/Hide
C11H13FN2O2
 1
1
Ki > 10000 nM
   TI
   LI
   LO
   TS
CP0001520
2,3,3a,4,6,6a-hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl-(5-bromofuran-2-yl)methanone
   Show/Hide
C11H13BrN2O2
 1
1
Ki > 10000 nM
   TI
   LI
   LO
   TS
CP0001526
3,7-diazabicyclo[3.3.1]nonan-3-yl-(5-methylfuran-2-yl)methanone
   Show/Hide
C13H18N2O2
 1
1
Ki > 10000 nM
   TI
   LI
   LO
   TS
CP0001527
5-(3,7-diazabicyclo[3.3.1]nonane-3-carbonyl)furan-3-carbonitrile
   Show/Hide
C13H15N3O2
 1
1
Ki > 10000 nM
   TI
   LI
   LO
   TS
CP0001528
(3-bromofuran-2-yl)-(3,7-diazabicyclo[3.3.1]nonan-3-yl)methanone
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C12H15BrN2O2
 1
1
Ki > 10000 nM
   TI
   LI
   LO
   TS
CP0001533
2-(3,7-diazabicyclo[3.3.1]nonane-3-carbonyl)furan-3-carbonitrile
   Show/Hide
C13H15N3O2
 1
1
Ki > 10000 nM
   TI
   LI
   LO
   TS
CP0001676
5-(2,3,3a,4,6,6a-hexahydro-1H-pyrrolo[3,4-c]pyrrole-5-carbonyl)furan-2-carbonitrile
   Show/Hide
C12H13N3O2
 1
1
Ki > 10000 nM
   TI
   LI
   LO
   TS
CP0002103
5-(3,7-diazabicyclo[3.3.1]nonane-3-carbonyl)furan-2-carbonitrile
   Show/Hide
C13H15N3O2
 1
1
Ki > 10000 nM
   TI
   LI
   LO
   TS
CP0002104
(4-chlorofuran-2-yl)-(3,7-diazabicyclo[3.3.1]nonan-3-yl)methanone
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C12H15ClN2O2
 1
1
Ki > 10000 nM
   TI
   LI
   LO
   TS
CP0002186
(5-bromofuran-2-yl)-(3,7-diazabicyclo[3.3.1]nonan-3-yl)methanone
   Show/Hide
C12H15BrN2O2
 1
1
Ki > 10000 nM
   TI
   LI
   LO
   TS
CP0002187
3,7-diazabicyclo[3.3.1]nonan-3-yl-(4-fluorofuran-2-yl)methanone
   Show/Hide
C12H15FN2O2
 1
1
Ki > 10000 nM
   TI
   LI
   LO
   TS
CP0002191
2,3,3a,4,6,6a-hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl-(4-fluorofuran-2-yl)methanone
   Show/Hide
C11H13FN2O2
 1
1
Ki > 10000 nM
   TI
   LI
   LO
   TS
CP0002196
3,7-diazabicyclo[3.3.1]nonan-3-yl-(3-methylfuran-2-yl)methanone
   Show/Hide
C13H18N2O2
 1
1
Ki > 10000 nM
   TI
   LI
   LO
   TS
CP0003271
(3-chlorofuran-2-yl)-(3,7-diazabicyclo[3.3.1]nonan-3-yl)methanone
   Show/Hide
C12H15ClN2O2
 1
1
Ki > 10000 nM
   TI
   LI
   LO
   TS
CP0005207
3,7-diazabicyclo[3.3.1]nonan-3-yl(pyridin-4-yl)methanone
   Show/Hide
C13H17N3O
 1
1
Ki > 10000 nM
   TI
   LI
   LO
   TS
CP0005209
(4-bromofuran-2-yl)-(3,7-diazabicyclo[3.3.1]nonan-3-yl)methanone
   Show/Hide
C12H15BrN2O2
 1
1
Ki > 10000 nM
   TI
   LI
   LO
   TS
CP0005645
(5-chlorofuran-2-yl)-(3,7-diazabicyclo[3.3.1]nonan-3-yl)methanone
   Show/Hide
C12H15ClN2O2
 1
1
Ki > 10000 nM
   TI
   LI
   LO
   TS
CP0635072
endo-(1R,5S)-N-propyl-3-azabicyclo[3.3.1]nonane-7-carboxamide
   Show/Hide
C12H22N2O
 1
1
Ki = 10000 nM
   TI
   LI
   LO
   TS
CP0634124
endo-(1R,5S)-N-isopropyl-3-azabicyclo[3.3.1]nonane-7-carboxamide
   Show/Hide
C12H22N2O
 1
1
Ki = 11000 nM
   TI
   LI
   LO
   TS
CP0001649
2,3,3a,4,6,6a-hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl-(4-phenoxyphenyl)methanone
   Show/Hide
C19H20N2O2
 1
1
Ki = 13000 nM
   TI
   LI
   LO
   TS
CP0001417
CHEMBL3037929
   Show/Hide
C9H15NO2
 1
1
Ki = 13000 nM
   TI
   LI
   LO
   TS
CP0001675
(5-bromofuran-2-yl)-[(1R,5S)-3,6-diazabicyclo[3.2.1]octan-3-yl]methanone
   Show/Hide
C11H13BrN2O2
 1
1
Ki = 14000 nM
   TI
   LI
   LO
   TS
CP0002189
[(1S,5R)-3,6-diazabicyclo[3.2.1]octan-3-yl]-(5-fluorofuran-2-yl)methanone
   Show/Hide
C11H13FN2O2
 1
1
Ki = 14000 nM
   TI
   LI
   LO
   TS
CP0005208
2,3,3a,4,6,6a-hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl(1,3-oxazol-2-yl)methanone
   Show/Hide
C10H13N3O2
 1
1
Ki = 14000 nM
   TI
   LI
   LO
   TS
CP0009418
(5-chlorofuran-2-yl)-[(1R,5S)-3,6-diazabicyclo[3.2.1]octan-3-yl]methanone
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C11H13ClN2O2
 1
1
Ki = 14000 nM
   TI
   LI
   LO
   TS
CP0001650
2,3,3a,4,6,6a-hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl(pyridin-4-yl)methanone
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C12H15N3O
 1
1
Ki = 15000 nM
   TI
   LI
   LO
   TS
CP0634125
endo-(1R,5S)-3-azabicyclo[3.3.1]nonan-7-yl(furan-2-yl)methanone
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C13H17NO2
 1
1
Ki = 15000 nM
   TI
   LI
   LO
   TS
CP0002195
2,3,3a,4,6,6a-hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl(1,2-oxazol-5-yl)methanone
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C10H13N3O2
 1
1
Ki = 19000 nM
   TI
   LI
   LO
   TS
CP0001673
2,3,3a,4,6,6a-hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl(phenyl)methanone
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C13H16N2O
 1
1
Ki = 20000 nM
   TI
   LI
   LO
   TS
CP0002185
2,3,3a,4,6,6a-hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl(pyridin-3-yl)methanone
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C12H15N3O
 1
1
Ki = 20000 nM
   TI
   LI
   LO
   TS
CP0000354
(3aR,6aS)-N-methyl-1,2,3,3a,4,5,6,6a-octahydrocyclopenta[c]pyrrole-5-carboxamide
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C9H16N2O
 1
1
Ki = 27000 nM
   TI
   LI
   LO
   TS
CP0002184
3,7-diazabicyclo[3.3.1]nonan-3-yl(phenyl)methanone
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C14H18N2O
 1
1
Ki = 34000 nM
   TI
   LI
   LO
   TS
CP0001524
(E)-4-(5-ethoxypyridin-3-yl)-N-methylbut-3-en-1-amine
   Show/Hide
C12H18N2O
 1
1
Ki = 71000 nM
   TI
   LI
   LO
   TS
CP0000916
2,3,3a,4,6,6a-hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl(furan-3-yl)methanone
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C11H14N2O2
 1
1
Ki = 100000 nM
   TI
   LI
   LO
   TS
CP0001672
3,7-diazabicyclo[3.3.1]nonan-3-yl-(4-methoxyphenyl)methanone
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C15H20N2O2
 1
1
Ki = 100000 nM
   TI
   LI
   LO
   TS
CP0002193
2,3,3a,4,6,6a-hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl-(4-methoxyphenyl)methanone
   Show/Hide
C14H18N2O2
 1
1
Ki = 100000 nM
   TI
   LI
   LO
   TS
CP0005712
2,3,3a,4,6,6a-hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl(pyridin-2-yl)methanone
   Show/Hide
C12H15N3O
 1
1
Ki = 100000 nM
   TI
   LI
   LO
   TS
CP0002172
2,3,3a,4,6,6a-hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl-[(1S,2S)-2-methylcyclopropyl]methanone
   Show/Hide
C11H18N2O
 1
1
Ki = 100000 nM
   TI
   LI
   LO
   TS
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0000212
()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]heptane
   Show/Hide
C11H13ClN2
 3
1 EC50 = 3500 nM
2 ED50 = 1100 nM
3 Ki = 25 nM
CP0004216
(S)-3-(azetidin-2-ylmethoxy)pyridine
   Show/Hide
C9H12N2O
 2
1 EC50 = 8900 nM
2 Ki = 148 nM
CP0633428
SID56463106
   Show/Hide
C11H14N2O
 2
1 EC50 = 71000 nM
2 Ki = 5890 nM
CP0000063
CAS_29790-52-1
   Show/Hide
C10H14N2
 3
1 EC50 = 83000 nM
2 Ki = 620 nM
3 Ki = 6290 nM
CP0634166
Methyllycaconitine
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C37H50N2O10
 1
1 IC50 > 1000 nM
CP0004845
(-)-Spiro[1-azabicyclo(2.2.2)octane-3,5'-oxazolidin-2'-one]
   Show/Hide
C9H14N2O2
 4
1 Kd = 92 nM
2 Ki = 92 nM
3 Ki = 340 nM
4 Ki = 420 nM
CP0009095
(3E)-3-[(2,4-DIMETHOXYPHENYL)METHYLIDENE]-3,4,5,6-TETRAHYDRO-2,3'-BIPYRIDINE
   Show/Hide
C19H20N2O2
 1
1 Kd = 158 nM
CP0101656
5'-phenyl-(2'R)-spiro[4-azabicyclo[2.2.2]octane-2,2'-furo[2,3-b]pyridine]
   Show/Hide
C19H20N2O
 1
1 Ki = 2 nM
CP0027747
(3R)-spiro[1-azabicyclo[2.2.2]octane-3,2'-3H-furo[2,3-b]pyridine]
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C13H16N2O
 1
1 Ki = 3 nM
CP0159901
N-[(3R)-1-azabicyclo[2.2.2]octan-3-yl]-7-chloro-1-benzothiophene-2-carboxamide
   Show/Hide
C16H17ClN2OS
 1
1 Ki = 4.3 nM
CP0285520
N-[(3S)-1-azabicyclo[2.2.2]octan-3-yl]-1H-indazole-3-carboxamide
   Show/Hide
C15H18N4O
 1
1 Ki = 6 nM
CP0047123
1,4-diazabicyclo[3.2.2]nonane-(4-bromo)-phenyl carbamate
   Show/Hide
C14H17BrN2O2
 1
1 Ki = 14 nM
CP0006822
(R)-4-chloro-N-(quinuclidin-3-yl)benzamide
   Show/Hide
C14H17ClN2O
 1
1 Ki = 26 nM
CP0638066
1-(1-(3-hydroxybenzyl)-1H-indol-3-yl)-N,N,N-trimethylmethanaminium iodide
   Show/Hide
C19H23IN2O
 1
1 Ki = 600 nM
CP0012937
3-Pyrrolidin-2-yl-pyridine
   Show/Hide
C9H12N2
 1
1 Ki = 730 nM
CP0635968
1-(1-(4-hydroxybenzyl)-1H-indol-3-yl)-N,N,N-trimethylmethanaminium iodide
   Show/Hide
C19H23IN2O
 1
1 Ki = 2900 nM
CP0002027
2-Methyl-3-((S)-1-pyrrolidin-2-ylmethoxy)-pyridine
   Show/Hide
C11H16N2O
 1
1 Ki > 10000 nM
Clinical Information about the Protein
Target 1 ( Neuronal acetylcholine receptor alpha-7 (CHRNA7) )
Target Type Successful Target
Disease 10 Target-related Diseases  10
1 Anaesthesia [ICD-11: 9A78.6]
2 Schizophrenia [ICD-11: 6A20]
3 Tobacco dependence [ICD-11: 6C4A.2]
4 Alzheimer disease [ICD-11: 8A20]
5 Chronic cough [ICD-11: MD12]
6 Parkinson disease [ICD-11: 8A00.0]
7 Cognitive impairment [ICD-11: 6D71]
8 Psychiatric disorder [ICD-11: 6E8Z]
9 Thrombosis [ICD-11: DB61-GB90]
10 Attention deficit hyperactivity disorder [ICD-11: 6A05.Z]
Approved Drug(s) 2 Approved Drugs  2
1 ALCURONIUM Approved
Anaesthesia
2 Ziprasidone Approved
Schizophrenia
Clinical Trial Drug(s) 8 Clinical Trial Drugs  8
1 CYTISINE Phase 3
Tobacco dependence
2 EVP-6124 Phase 3
Schizophrenia
3 AQW-051 Phase 2
Alzheimer disease
4 Bradanicline Phase 2
Chronic cough
5 GTS-21 Phase 2
Parkinson disease
6 AVL-3288 Phase 1
Cognitive impairment
7 BMS-933043 Phase 1
Psychiatric disorder
8 BNC375 Phase 1
Cognitive impairment
Discontinued Drug(s) 4 Discontinued Drugs  4
1 AZD-9684 Discontinued in Phase 2
Thrombosis
2 AZD0328 Discontinued in Phase 2
Alzheimer disease
3 ABT-107 Discontinued in Phase 1
Attention deficit hyperactivity disorder
4 PNU-282987 Terminated
Schizophrenia
Investigative Drug(s) 1 Investigative Drug  1
1 JNJ-1930942 Investigative
Cognitive impairment
Preclinical Drug(s) 1 Preclinical Drug  1
1 PHA-568487 Preclinical
Cognitive impairment
Similar Protein(s) and Bioactivity Statistics
90% Identity
Protein ID Protein Name Protein Organism
PT02118 Neuronal acetylcholine receptor subunit alpha-7 Rattus norvegicus, Rat