General Information of the Compound
Compound ID
CP0008057
Compound Name
7-(2-methoxyphenyl)-N-[(2S,3R)-2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]octan-3-yl]-1-benzofuran-2-carboxamide
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Structure
Formula
C29H29N3O3
Molecular Weight
467.569
Canonical SMILES
COc1ccccc1-c1cccc2cc(oc12)C(=O)N[C@@H]1C2CCN(CC2)[C@H]1Cc1cccnc1
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InChI
InChI=1S/C29H29N3O3/c1-34-25-10-3-2-8-22(25)23-9-4-7-21-17-26(35-28(21)23)29(33)31-27-20-11-14-32(15-12-20)24(27)16-19-6-5-13-30-18-19/h2-10,13,17-18,20,24,27H,11-12,14-16H2,1H3,(H,31,33)/t24-,27+/m0/s1
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InChIKey
GJGCMSZTXVMITL-RPLLCQBOSA-N
Physicochemical Property
logP
4.9387
Rotatable Bonds
6
Heavy Atom Count
35
Polar Areas
67.6
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
5
Complexity
35

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 71462717
SID: 163502421
ChEMBL ID
CHEMBL2180262
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02118, Neuronal acetylcholine receptor subunit alpha-7
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000029 GH4C1 Rattus norvegicus (Rat)  1
1
EC50 = 140 nM
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Protein ID: PT01846, Neuronal acetylcholine receptor subunit alpha-7
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 59 nM
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