General Information of the Compound
Compound ID
CP0010515
Compound Name
N-[(2S,3R)-2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]octan-3-yl]-1,2-oxazole-3-carboxamide
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Structure
Formula
C17H20N4O2
Molecular Weight
312.373
Canonical SMILES
O=C(N[C@@H]1C2CCN(CC2)[C@H]1Cc1cccnc1)c1ccon1
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InChI
InChI=1S/C17H20N4O2/c22-17(14-5-9-23-20-14)19-16-13-3-7-21(8-4-13)15(16)10-12-2-1-6-18-11-12/h1-2,5-6,9,11,13,15-16H,3-4,7-8,10H2,(H,19,22)/t15-,16+/m0/s1
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InChIKey
UKKSFWJVMANCNS-JKSUJKDBSA-N
Physicochemical Property
logP
1.5049
Rotatable Bonds
4
Heavy Atom Count
23
Polar Areas
71.26
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
5
Complexity
23

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 71451985
SID: 163506688
ChEMBL ID
CHEMBL2179869
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02118, Neuronal acetylcholine receptor subunit alpha-7
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000029 GH4C1 Rattus norvegicus (Rat)  1
1
EC50 = 10000 nM
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Protein ID: PT01846, Neuronal acetylcholine receptor subunit alpha-7
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 1097 nM
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