General Information of the Compound
Compound ID
CP0004176
Compound Name
5-(azepan-1-yl)-N-[5-(4-methoxyphenyl)-1H-pyrazol-3-yl]pentanamide
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Structure
Formula
C21H30N4O2
Molecular Weight
370.497
Canonical SMILES
COc1ccc(cc1)-c1cc(NC(=O)CCCCN2CCCCCC2)[nH]n1
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InChI
InChI=1S/C21H30N4O2/c1-27-18-11-9-17(10-12-18)19-16-20(24-23-19)22-21(26)8-4-7-15-25-13-5-2-3-6-14-25/h9-12,16H,2-8,13-15H2,1H3,(H2,22,23,24,26)
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InChIKey
LZQMVVGBOPZASC-UHFFFAOYSA-N
Physicochemical Property
logP
4.0701
Rotatable Bonds
8
Heavy Atom Count
27
Polar Areas
70.25
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
4
Complexity
27

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 57523414
SID: 137281029
ChEMBL ID
CHEMBL2087456
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02227, 5-hydroxytryptamine receptor 3A
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 > 30000 nM
   TI
   LI
   LO
   TS
Protein ID: PT02515, Neuronal acetylcholine receptor subunit alpha-3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000004 SH-SY5Y Homo sapiens (Human)  1
1
IC50 > 30000 nM
   TI
   LI
   LO
   TS
Protein ID: PT02118, Neuronal acetylcholine receptor subunit alpha-7
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000029 GH4C1 Rattus norvegicus (Rat)  1
1
EC50 = 1050 nM
   TI
   LI
   LO
   TS