General Information of the Compound
Compound ID
CP0441474
Compound Name
2'-Chlorobiphenyl-4-carboxylic acid{4-[4-(2,4-dimethoxyphenyl)piperazin-1-yl]butyl}-amide
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Structure
Formula
C29H34ClN3O3
Molecular Weight
508.062
Canonical SMILES
COc1ccc(N2CCN(CCCCNC(=O)c3ccc(cc3)-c3ccccc3Cl)CC2)c(OC)c1
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InChI
InChI=1S/C29H34ClN3O3/c1-35-24-13-14-27(28(21-24)36-2)33-19-17-32(18-20-33)16-6-5-15-31-29(34)23-11-9-22(10-12-23)25-7-3-4-8-26(25)30/h3-4,7-14,21H,5-6,15-20H2,1-2H3,(H,31,34)
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InChIKey
KJMFPCFBWFNCEJ-UHFFFAOYSA-N
Physicochemical Property
logP
5.3564
Rotatable Bonds
10
Heavy Atom Count
36
Polar Areas
54.04
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
5
Complexity
36

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 45484326
ChEMBL ID
CHEMBL568002
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02118, Neuronal acetylcholine receptor subunit alpha-7
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000029 GH4C1 Rattus norvegicus (Rat)  1
1
EC50 = 3110 nM
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