Protein Information

General Information of the Protein

Protein ID	PT01378
Protein Name	Leucine-rich repeat serine/threonine-protein kinase 2
Secondarily Protein Name	Dardarin
Gene Name	LRRK2
Secondarily Gene Name	PARK8
Sequence	MASGSCQGCEEDEETLKKLIVRLNNVQEGKQIETLVQILEDLLVFTYSERASKLFQGKNIHVPLLIVLDSYMRVASVQQVGWSLLCKLIEVCPGTMQSLMGPQDVGNDWEVLGVHQLILKMLTVHNASVNLSVIGLKTLDLLLTSGKITLLILDEESDIFMLIFDAMHSFPANDEVQKLGCKALHVLFERVSEEQLTEFVENKDYMILLSALTNFKDEEEIVLHVLHCLHSLAIPCNNVEVLMSGNVRCYNIVVEAMKAFPMSERIQEVSCCLLHRLTLGNFFNILVLNEVHEFVVKAVQQYPENAALQISALSCLALLTETIFLNQDLEEKNENQENDDEGEEDKLFWLEACYKALTWHRKNKHVQEAACWALNNLLMYQNSLHEKIGDEDGHFPAHREVMLSMLMHSSSKEVFQASANALSTLLEQNVNFRKILLSKGIHLNVLELMQKHIHSPEVAESGCKMLNHLFEGSNTSLDIMAAVVPKILTVMKRHETSLPVQLEALRAILHFIVPGMPEESREDTEFHHKLNMVKKQCFKNDIHKLVLAALNRFIGNPGIQKCGLKVISSIVHFPDALEMLSLEGAMDSVLHTLQMYPDDQEIQCLGLSLIGYLITKKNVFIGTGHLLAKILVSSLYRFKDVAEIQTKGFQTILAILKLSASFSKLLVHHSFDLVIFHQMSSNIMEQKDQQFLNLCCKCFAKVAMDDYLKNVMLERACDQNNSIMVECLLLLGADANQAKEGSSLICQVCEKESSPKLVELLLNSGSREQDVRKALTISIGKGDSQIISLLLRRLALDVANNSICLGGFCIGKVEPSWLGPLFPDKTSNLRKQTNIASTLARMVIRYQMKSAVEEGTASGSDGNFSEDVLSKFDEWTFIPDSSMDSVFAQSDDLDSEGSEGSFLVKKKSNSISVGEFYRDAVLQRCSPNLQRHSNSLGPIFDHEDLLKRKRKILSSDDSLRSSKLQSHMRHSDSISSLASEREYITSLDLSANELRDIDALSQKCCISVHLEHLEKLELHQNALTSFPQQLCETLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGICSPLRLKELKILNLSKNHISSLSENFLEACPKVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFDFKHIGCKAKDIIRFLQQRLKKAVPYNRMKLMIVGNTGSGKTTLLQQLMKTKKSDLGMQSATVGIDVKDWPIQIRDKRKRDLVLNVWDFAGREEFYSTHPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKARASSSPVILVGTHLDVSDEKQRKACMSKITKELLNKRGFPAIRDYHFVNATEESDALAKLRKTIINESLNFKIRDQLVVGQLIPDCYVELEKIILSERKNVPIEFPVIDRKRLLQLVRENQLQLDENELPHAVHFLNESGVLLHFQDPALQLSDLYFVEPKWLCKIMAQILTVKVEGCPKHPKGIISRRDVEKFLSKKRKFPKNYMSQYFKLLEKFQIALPIGEEYLLVPSSLSDHRPVIELPHCENSEIIIRLYEMPYFPMGFWSRLINRLLEISPYMLSGRERALRPNRMYWRQGIYLNWSPEAYCLVGSEVLDNHPESFLKITVPSCRKGCILLGQVVDHIDSLMEEWFPGLLEIDICGEGETLLKKWALYSFNDGEEHQKILLDDLMKKAEEGDLLVNPDQPRLTIPISQIAPDLILADLPRNIMLNNDELEFEQAPEFLLGDGSFGSVYRAAYEGEEVAVKIFNKHTSLRLLRQELVVLCHLHHPSLISLLAAGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELVCLTRRILLPKNVIVECMVATHHNSRNASIWLGCGHTDRGQLSFLDLNTEGYTSEEVADSRILCLALVHLPVEKESWIVSGTQSGTLLVINTEDGKKRHTLEKMTDSVTCLYCNSFSKQSKQKNFLLVGTADGKLAIFEDKTVKLKGAAPLKILNIGNVSTPLMCLSESTNSTERNVMWGGCGTKIFSFSNDFTIQKLIETRTSQLFSYAAFSDSNIITVVVDTALYIAKQNSPVVEVWDKKTEKLCGLIDCVHFLREVMVKENKESKHKMSYSGRVKTLCLQKNTALWIGTGGGHILLLDLSTRRLIRVIYNFCNSVRVMMTAQLGSLKNVMLVLGYNRKNTEGTQKQKEIQSCLTVWDINLPHEVQNLEKHIEVRKELAEKMRRTSVE Show/Hide
Organism	Homo sapiens, Human
Protein Classification	Enzyme > Kinase > Protein Kinase > TKL protein kinase group > TKL protein kinase LRRK family
Function	Serine/threonine-protein kinase which phosphorylates a broad range of proteins involved in multiple processes such as neuronal plasticity, innate immunity, autophagy, and vesicle trafficking (PubMed:20949042, PubMed:22012985, PubMed:26824392, PubMed:27830463, PubMed:29125462, PubMed:28720718, PubMed:29127255, PubMed:30398148, PubMed:29212815, PubMed:30635421, PubMed:21850687, PubMed:23395371, PubMed:17114044, PubMed:24687852, PubMed:26014385, PubMed:25201882). Is a key regulator of RAB GTPases by regulating the GTP/GDP exchange and interaction partners of RABs through phosphorylation (PubMed:26824392, PubMed:28720718, PubMed:29127255, PubMed:30398148, PubMed:29212815, PubMed:29125462, PubMed:30635421). Phosphorylates RAB3A, RAB3B, RAB3C, RAB3D, RAB5A, RAB5B, RAB5C, RAB8A, RAB8B, RAB10, RAB12, RAB35, and RAB43 (PubMed:26824392, PubMed:28720718, PubMed:29127255, PubMed:30398148, PubMed:29212815, PubMed:29125462, PubMed:30635421, PubMed:23395371). Regulates the RAB3IP-catalyzed GDP/GTP exchange for RAB8A through the phosphorylation of 'Thr-72' on RAB8A (PubMed:26824392). Inhibits the interaction between RAB8A and GDI1 and/or GDI2 by phosphorylating 'Thr-72' on RAB8A (PubMed:26824392). Regulates primary ciliogenesis through phosphorylation of RAB8A and RAB10, which promotes SHH signaling in the brain (PubMed:29125462, PubMed:30398148). Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose-6-phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner (PubMed:23395371). Regulates neuronal process morphology in the intact central nervous system (CNS) (PubMed:17114044). Plays a role in synaptic vesicle trafficking (PubMed:24687852). Plays an important role in recruiting SEC16A to endoplasmic reticulum exit sites (ERES) and in regulating ER to Golgi vesicle-mediated transport and ERES organization (PubMed:25201882). Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway (PubMed:22012985). The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes (PubMed:22012985). Phosphorylates PRDX3 (PubMed:21850687). By phosphorylating APP on 'Thr-743', which promotes the production and the nuclear translocation of the APP intracellular domain (AICD), regulates dopaminergic neuron apoptosis (PubMed:28720718). Acts as a positive regulator of innate immunity by mediating phosphorylation of RIPK2 downstream of NOD1 and NOD2, thereby enhancing RIPK2 activation (PubMed:27830463). Independent of its kinase activity, inhibits the proteasomal degradation of MAPT, thus promoting MAPT oligomerization and secretion (PubMed:26014385). In addition, has GTPase activity via its Roc domain which regulates LRRK2 kinase activity (PubMed:18230735, PubMed:26824392, PubMed:29125462, PubMed:28720718, PubMed:29212815). Show/Hide
Uniprot ID	Primary ID: Q5S007 Secondarily ID: A6NJU2 Q6ZS50 Q8NCX9 Show/Hide
Ensembl ID	ENSG00000188906
HGNC ID	HGNC:18618
Subcellular Location	Cytoplasmic vesicle Perikaryon Golgi apparatus membrane Cell projection Axon Cell projection Dendrite Endoplasmic reticulum membrane Cytoplasmic vesicle Secretory vesicle Synaptic vesicle membrane Endosome Lysosome Mitochondrion outer membrane Cytoplasm Cytoskeleton

Map of Molecular Bioactivity Related to the Protein

Map of Molecular Bioactivity Related to the Protein Protein Cell Line Compound Bioactivity Value: <= 0.1 μM > 0.1 μM and <= 10 μM > 10 μM Imprecise Activity

Table of Molecular Bioactivities Related to the Protein

Cell Line ID: CL000006 , HEK293

Cell Line Info

Compound ID	Compound Name	Compound Formula
CP0572904 Compound Info	(5S)-5-[[3-(2-morpholin-4-ylpyridin-4-yl)-1H-indazol-5-yl]amino]-5,6,7,8-tetrahydronaphthalene-2-carbonitrile Show/Hide	C27H26N6O	2
1	EC50 = 17 nM Bioactivity Info	TI LI LO TS
2	EC50 = 260 nM Bioactivity Info	TI LI LO TS
CP0546499 Compound Info	(5S)-5-[[3-(2,6-dimethylpyridin-4-yl)-1H-indazol-5-yl]amino]-5,6,7,8-tetrahydronaphthalene-2-carbonitrile Show/Hide	C25H23N5	2
1	EC50 = 20 nM Bioactivity Info	TI LI LO TS
2	EC50 = 700 nM Bioactivity Info	TI LI LO TS
CP0564501 Compound Info	(5S)-5-[[3-(2-methylpyridin-4-yl)-1H-indazol-5-yl]amino]-5,6,7,8-tetrahydronaphthalene-2-carbonitrile Show/Hide	C24H21N5	2
1	EC50 = 20 nM Bioactivity Info	TI LI LO TS
2	EC50 = 800 nM Bioactivity Info	TI LI LO TS
CP0644312 Compound Info	cis-2,6-Dimethyl-4-(6-(5-(1-methylcyclopropoxy)-1H-indazol-3-yl)pyrimidin-4-yl)morpholine Show/Hide	C21H25N5O2	2
1	EC50 = 23 nM Bioactivity Info	TI LI LO TS
2	EC50 = 30 nM Bioactivity Info	TI LI LO TS
CP0033205 Compound Info	(5R)-5-[[3-(2-methylpyridin-4-yl)-1H-indazol-5-yl]amino]-5,6,7,8-tetrahydronaphthalene-2-carbonitrile Show/Hide	C24H21N5	2
1	EC50 = 40 nM Bioactivity Info	TI LI LO TS
2	EC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0568003 Compound Info	4-[[3-(2-methylpyridin-4-yl)-1H-indazol-5-yl]amino]benzene-1,3-dicarbonitrile Show/Hide	C21H14N6	2
1	EC50 = 60 nM Bioactivity Info	TI LI LO TS
2	EC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0218399 Compound Info	4-[[(1R)-1-cyclopropylethyl]amino]-7-pyridin-4-ylcinnoline-3-carboxamide Show/Hide	C19H19N5O	1
1	EC50 = 62 nM Bioactivity Info	TI LI LO TS
CP0023856 Compound Info	4-[[(1R)-1-cyclopropylethyl]amino]-7-(4-methylsulfonylphenyl)cinnoline-3-carboxamide Show/Hide	C21H22N4O3S	1
1	EC50 = 70 nM Bioactivity Info	TI LI LO TS
CP0568785 Compound Info	(5R)-5-[[3-(2,6-dimethylpyridin-4-yl)-1H-indazol-5-yl]amino]-5,6,7,8-tetrahydronaphthalene-2-carbonitrile Show/Hide	C25H23N5	2
1	EC50 = 70 nM Bioactivity Info	TI LI LO TS
2	EC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0570264 Compound Info	(5S)-5-[(3-pyridin-4-yl-1H-indazol-5-yl)amino]-5,6,7,8-tetrahydronaphthalene-2-carbonitrile Show/Hide	C23H19N5	2
1	EC50 = 70 nM Bioactivity Info	TI LI LO TS
2	EC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0067767 Compound Info	4-[[(2R)-butan-2-yl]amino]-7-(4-methylsulfonylphenyl)cinnoline-3-carboxamide Show/Hide	C20H22N4O3S	1
1	EC50 = 73 nM Bioactivity Info	TI LI LO TS
CP0543315 Compound Info	(4R)-4-[[3-(2,6-dimethylpyridin-4-yl)-1H-indazol-5-yl]amino]-3,4-dihydro-2H-chromene-7-carbonitrile Show/Hide	C24H21N5O	2
1	EC50 = 90 nM Bioactivity Info	TI LI LO TS
2	EC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0019734 Compound Info	4-(propan-2-ylamino)-6-(1H-pyrazol-4-yl)cinnoline-3-carboxamide Show/Hide	C15H16N6O	1
1	EC50 = 109 nM Bioactivity Info	TI LI LO TS
CP0579368 Compound Info	(5R)-5-[[3-(2-morpholin-4-ylpyridin-4-yl)-1H-indazol-5-yl]amino]-5,6,7,8-tetrahydronaphthalene-2-carbonitrile Show/Hide	C27H26N6O	2
1	EC50 = 110 nM Bioactivity Info	TI LI LO TS
2	EC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0019820 Compound Info	7-(1-methylpyrazol-4-yl)-4-(propan-2-ylamino)quinoline-3-carbonitrile Show/Hide	C17H17N5	1
1	EC50 = 140 nM Bioactivity Info	TI LI LO TS
CP0033544 Compound Info	2-[[3-(2-methylpyridin-4-yl)-1H-indazol-5-yl]amino]benzonitrile Show/Hide	C20H15N5	2
1	EC50 = 150 nM Bioactivity Info	TI LI LO TS
2	EC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0564488 Compound Info	4-[(3-pyridin-4-yl-1H-indazol-5-yl)amino]-3,4-dihydro-2H-chromene-7-carbonitrile Show/Hide	C22H17N5O	2
1	EC50 = 160 nM Bioactivity Info	TI LI LO TS
2	EC50 = 30000 nM Bioactivity Info	TI LI LO TS
CP0574429 Compound Info	1-[(3-pyridin-4-yl-1H-indazol-5-yl)amino]-2,3-dihydro-1H-indene-5-carbonitrile Show/Hide	C22H17N5	2
1	EC50 = 200 nM Bioactivity Info	TI LI LO TS
2	EC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0067768 Compound Info	7-(4-methylsulfonylphenyl)-4-(propan-2-ylamino)cinnoline-3-carboxamide Show/Hide	C19H20N4O3S	1
1	EC50 = 218 nM Bioactivity Info	TI LI LO TS
CP0321712 Compound Info	4-[3-cyano-4-(propan-2-ylamino)quinolin-7-yl]-N-methylbenzenesulfonamide Show/Hide	C20H20N4O2S	1
1	EC50 = 226 nM Bioactivity Info	TI LI LO TS
CP0022216 Compound Info	4-(propan-2-ylamino)-7-pyridin-4-ylcinnoline-3-carboxamide Show/Hide	C17H17N5O	1
1	EC50 = 242 nM Bioactivity Info	TI LI LO TS
CP0233613 Compound Info	4-(propan-2-ylamino)-7-(1,2-thiazol-4-yl)cinnoline-3-carboxamide Show/Hide	C15H15N5OS	1
1	EC50 = 290 nM Bioactivity Info	TI LI LO TS
CP0550091 Compound Info	(5R)-5-[[3-(1-methylpyrazol-4-yl)-1H-indazol-5-yl]amino]-5,6,7,8-tetrahydronaphthalene-2-carbonitrile Show/Hide	C22H20N6	2
1	EC50 = 290 nM Bioactivity Info	TI LI LO TS
2	EC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0543316 Compound Info	(5R)-5-[(3-pyridin-4-yl-1H-indazol-5-yl)amino]-5,6,7,8-tetrahydronaphthalene-2-carbonitrile Show/Hide	C23H19N5	2
1	EC50 = 310 nM Bioactivity Info	TI LI LO TS
2	EC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0573657 Compound Info	(4R)-4-[(3-pyridin-4-yl-1H-indazol-5-yl)amino]-3,4-dihydro-2H-chromene-7-carbonitrile Show/Hide	C22H17N5O	2
1	EC50 = 320 nM Bioactivity Info	TI LI LO TS
2	EC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0031119 Compound Info	4-[(3-pyridin-4-yl-1H-indazol-5-yl)amino]benzene-1,3-dicarbonitrile Show/Hide	C20H12N6	2
1	EC50 = 370 nM Bioactivity Info	TI LI LO TS
2	EC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0564492 Compound Info	3-fluoro-2-[(3-pyridin-4-yl-1H-indazol-5-yl)amino]benzonitrile Show/Hide	C19H12FN5	2
1	EC50 = 390 nM Bioactivity Info	TI LI LO TS
2	EC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0077182 Compound Info	7-(4-morpholin-4-ylsulfonylphenyl)-4-(propan-2-ylamino)quinoline-3-carbonitrile Show/Hide	C23H24N4O3S	1
1	EC50 = 416 nM Bioactivity Info	TI LI LO TS
CP0016537 Compound Info	7-(4-methylsulfonylphenyl)-4-(propan-2-ylamino)quinoline-3-carbonitrile Show/Hide	C20H19N3O2S	1
1	EC50 = 435 nM Bioactivity Info	TI LI LO TS
CP0114881 Compound Info	4-(azetidin-1-yl)-7-(1-methylpyrazol-4-yl)quinoline-3-carbonitrile Show/Hide	C17H15N5	1
1	EC50 = 504 nM Bioactivity Info	TI LI LO TS
CP0545147 Compound Info	5-methyl-2-[(3-pyridin-4-yl-1H-indazol-5-yl)amino]benzonitrile Show/Hide	C20H15N5	2
1	EC50 = 530 nM Bioactivity Info	TI LI LO TS
2	EC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0185411 Compound Info	7-(2-methyl-1,3-thiazol-5-yl)-4-(propan-2-ylamino)quinoline-3-carbonitrile Show/Hide	C17H16N4S	1
1	EC50 = 545 nM Bioactivity Info	TI LI LO TS
CP0568096 Compound Info	N-(2-nitrophenyl)-3-pyridin-4-yl-1H-indazol-5-amine Show/Hide	C18H13N5O2	2
1	EC50 = 570 nM Bioactivity Info	TI LI LO TS
2	EC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0572902 Compound Info	2-fluoro-6-[(3-pyridin-4-yl-1H-indazol-5-yl)amino]benzonitrile Show/Hide	C19H12FN5	2
1	EC50 = 620 nM Bioactivity Info	TI LI LO TS
2	EC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0568097 Compound Info	2-[(3-pyridin-4-yl-1H-indazol-5-yl)amino]benzonitrile Show/Hide	C19H13N5	2
1	EC50 = 670 nM Bioactivity Info	TI LI LO TS
2	EC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0577522 Compound Info	2-[[3-(2-methoxypyridin-4-yl)-1H-indazol-5-yl]amino]benzonitrile Show/Hide	C20H15N5O	2
1	EC50 = 690 nM Bioactivity Info	TI LI LO TS
2	EC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0550120 Compound Info	N-(3,4-dihydro-2H-chromen-4-yl)-3-pyridin-4-yl-1H-indazol-5-amine Show/Hide	C21H18N4O	2
1	EC50 = 730 nM Bioactivity Info	TI LI LO TS
2	EC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0019480 Compound Info	4-[[(1R)-1-cyclopropylethyl]amino]-7-[4-(2-oxo-1,3-oxazol-3-yl)phenyl]quinoline-3-carbonitrile Show/Hide	C24H20N4O2	1
1	EC50 = 731 nM Bioactivity Info	TI LI LO TS
CP0568101 Compound Info	(5R)-5-[(6-fluoro-3-pyridin-4-yl-1H-indazol-5-yl)amino]-5,6,7,8-tetrahydronaphthalene-2-carbonitrile Show/Hide	C23H18FN5	2
1	EC50 = 750 nM Bioactivity Info	TI LI LO TS
2	EC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0550119 Compound Info	(4R)-4-[[3-(2-methylpyridin-4-yl)-1H-indazol-5-yl]amino]-3,4-dihydro-2H-chromene-7-carbonitrile Show/Hide	C23H19N5O	2
1	EC50 = 760 nM Bioactivity Info	TI LI LO TS
2	EC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0546879 Compound Info	2-methyl-3-[[(3-pyridin-4-yl-1H-indazol-5-yl)amino]methyl]benzonitrile Show/Hide	C21H17N5	2
1	EC50 = 790 nM Bioactivity Info	TI LI LO TS
2	EC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0578424 Compound Info	4-[(3-pyridin-4-yl-1H-indazol-5-yl)amino]benzonitrile Show/Hide	C19H13N5	2
1	EC50 = 930 nM Bioactivity Info	TI LI LO TS
2	EC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0577652 Compound Info	3-nitro-4-[(3-pyridin-4-yl-1H-indazol-5-yl)oxy]benzonitrile Show/Hide	C19H11N5O3	2
1	EC50 = 1080 nM Bioactivity Info	TI LI LO TS
2	EC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0065744 Compound Info	4-(dimethylamino)-7-(4-methylsulfonylphenyl)quinoline-3-carbonitrile Show/Hide	C19H17N3O2S	1
1	EC50 = 1134 nM Bioactivity Info	TI LI LO TS
CP0031120 Compound Info	3-nitro-4-[(3-pyridin-4-yl-1H-indazol-5-yl)amino]benzonitrile Show/Hide	C19H12N6O2	2
1	EC50 = 1400 nM Bioactivity Info	TI LI LO TS
2	EC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0077181 Compound Info	7-(4-methylsulfonylphenyl)-4-piperidin-1-ylquinoline-3-carbonitrile Show/Hide	C22H21N3O2S	1
1	EC50 = 1599 nM Bioactivity Info	TI LI LO TS
CP0262506 Compound Info	7-(6-methylsulfonylpyridin-3-yl)-4-(propan-2-ylamino)quinoline-3-carbonitrile Show/Hide	C19H18N4O2S	1
1	EC50 = 1599 nM Bioactivity Info	TI LI LO TS
CP0568098 Compound Info	3-[[(3-pyridin-4-yl-1H-indazol-5-yl)amino]methyl]benzonitrile Show/Hide	C20H15N5	2
1	EC50 = 1700 nM Bioactivity Info	TI LI LO TS
2	EC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0568099 Compound Info	(5R)-5-[[3-(2-methoxypyridin-4-yl)-1H-indazol-5-yl]amino]-5,6,7,8-tetrahydronaphthalene-2-carbonitrile Show/Hide	C24H21N5O	2
1	EC50 = 1840 nM Bioactivity Info	TI LI LO TS
2	EC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0065790 Compound Info	7-(5-chlorothiophen-2-yl)-4-(propan-2-ylamino)quinoline-3-carbonitrile Show/Hide	C17H14ClN3S	1
1	EC50 = 2621 nM Bioactivity Info	TI LI LO TS
CP0543313 Compound Info	5-fluoro-2-[(3-pyridin-4-yl-1H-indazol-5-yl)amino]benzonitrile Show/Hide	C19H12FN5	2
1	EC50 = 2890 nM Bioactivity Info	TI LI LO TS
2	EC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0546878 Compound Info	5-methoxy-2-[(3-pyridin-4-yl-1H-indazol-5-yl)amino]benzonitrile Show/Hide	C20H15N5O	2
1	EC50 = 3290 nM Bioactivity Info	TI LI LO TS
2	EC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0543311 Compound Info	(5R)-5-[[3-pyridin-4-yl-6-(trifluoromethyl)-1H-indazol-5-yl]amino]-5,6,7,8-tetrahydronaphthalene-2-carbonitrile Show/Hide	C24H18F3N5	2
1	EC50 = 3300 nM Bioactivity Info	TI LI LO TS
2	EC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0546880 Compound Info	5-[(3-pyridin-4-yl-1H-indazol-5-yl)amino]naphthalene-2-carbonitrile Show/Hide	C23H15N5	2
1	EC50 = 6300 nM Bioactivity Info	TI LI LO TS
2	EC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0573659 Compound Info	2-methyl-6-[(3-pyridin-4-yl-1H-indazol-5-yl)amino]benzonitrile Show/Hide	C20H15N5	2
1	EC50 = 13000 nM Bioactivity Info	TI LI LO TS
2	EC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0564486 Compound Info	3-methyl-2-[(3-pyridin-4-yl-1H-indazol-5-yl)amino]benzonitrile Show/Hide	C20H15N5	2
1	EC50 = 35000 nM Bioactivity Info	TI LI LO TS
2	EC50 = 100000 nM Bioactivity Info	TI LI LO TS
CP0564500 Compound Info	3-[(1S)-1-[(3-pyridin-4-yl-1H-indazol-5-yl)amino]ethyl]benzonitrile Show/Hide	C21H17N5	2
1	EC50 = 40000 nM Bioactivity Info	TI LI LO TS
2	EC50 = 50000 nM Bioactivity Info	TI LI LO TS
CP0573658 Compound Info	3-methoxy-2-[(3-pyridin-4-yl-1H-indazol-5-yl)amino]benzonitrile Show/Hide	C20H15N5O	2
1	EC50 = 49000 nM Bioactivity Info	TI LI LO TS
2	EC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0564491 Compound Info	2-[(3-pyridin-4-yl-1H-indazol-5-yl)oxy]benzonitrile Show/Hide	C19H12N4O	2
1	EC50 = 49800 nM Bioactivity Info	TI LI LO TS
2	EC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0564490 Compound Info	3-methyl-4-[(3-pyridin-4-yl-1H-indazol-5-yl)oxy]benzonitrile Show/Hide	C20H14N4O	2
1	EC50 = 60000 nM Bioactivity Info	TI LI LO TS
2	EC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0550117 Compound Info	4-[[(3-pyridin-4-yl-1H-indazol-5-yl)amino]methyl]benzonitrile Show/Hide	C20H15N5	2
1	EC50 = 80000 nM Bioactivity Info	TI LI LO TS
2	EC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0152600 Compound Info	3-nitro-4-[(2-oxo-1,3-dihydrobenzimidazol-5-yl)amino]benzonitrile Show/Hide	C14H9N5O3	1
1	EC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0545146 Compound Info	4-methyl-2-[(3-pyridin-4-yl-1H-indazol-5-yl)amino]benzonitrile Show/Hide	C20H15N5	1
1	EC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0546886 Compound Info	4-fluoro-2-[(3-pyridin-4-yl-1H-indazol-5-yl)amino]benzonitrile Show/Hide	C19H12FN5	1
1	EC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0546889 Compound Info	4-methoxy-2-[(3-pyridin-4-yl-1H-indazol-5-yl)amino]benzonitrile Show/Hide	C20H15N5O	1
1	EC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0550121 Compound Info	4-[methyl-(3-pyridin-4-yl-1H-indazol-5-yl)amino]benzene-1,3-dicarbonitrile Show/Hide	C21H14N6	1
1	EC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0550122 Compound Info	4-[(3-pyridin-4-yl-1H-indazol-5-yl)oxy]benzene-1,3-dicarbonitrile Show/Hide	C20H11N5O	1
1	EC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0564489 Compound Info	3-nitro-4-[(2-oxo-3-pyridin-4-yl-1H-benzimidazol-5-yl)amino]benzonitrile Show/Hide	C19H12N6O3	1
1	EC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0571222 Compound Info	3-nitro-2-[(3-pyridin-4-yl-1H-indazol-5-yl)amino]benzonitrile Show/Hide	C19H12N6O2	2
1	EC50 > 100000 nM Bioactivity Info	TI LI LO TS
2	EC50 = 100000 nM Bioactivity Info	TI LI LO TS
CP0577653 Compound Info	3-chloro-4-[(3-pyridin-4-yl-1H-indazol-5-yl)amino]benzonitrile Show/Hide	C19H12ClN5	1
1	EC50 > 100000 nM Bioactivity Info	TI LI LO TS
CP0339215 Compound Info	[4-[[4-(cyclopropylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]-2-fluoro-5-methoxyphenyl]-morpholin-4-ylmethanone Show/Hide	C20H21F4N5O3	1
1	IC50 = 4 nM Bioactivity Info	TI LI LO TS
CP0179674 Compound Info	[2-chloro-5-methoxy-4-[[4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]phenyl]-morpholin-4-ylmethanone Show/Hide	C18H19ClF3N5O3	1
1	IC50 = 7 nM Bioactivity Info	TI LI LO TS
CP0170077 Compound Info	[3-methoxy-4-[[4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]phenyl]-morpholin-4-ylmethanone Show/Hide	C18H20F3N5O3	1
1	IC50 = 9 nM Bioactivity Info	TI LI LO TS
CP0179673 Compound Info	[4-[[4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]-2-fluoro-5-methoxyphenyl]-morpholin-4-ylmethanone Show/Hide	C19H21F4N5O3	1
1	IC50 = 9 nM Bioactivity Info	TI LI LO TS
CP0301154 Compound Info	4-[[4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]-2-fluoro-N-(2-hydroxy-2-methylpropyl)-5-methoxybenzamide Show/Hide	C19H23F4N5O3	1
1	IC50 = 10 nM Bioactivity Info	TI LI LO TS
CP0087578 Compound Info	[5-methoxy-2-methyl-4-[[4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]phenyl]-morpholin-4-ylmethanone Show/Hide	C19H22F3N5O3	1
1	IC50 = 11 nM Bioactivity Info	TI LI LO TS
CP0262172 Compound Info	[4-[[5-bromo-4-(methylamino)pyrimidin-2-yl]amino]-3-methoxyphenyl]-morpholin-4-ylmethanone Show/Hide	C17H20BrN5O3	1
1	IC50 = 13 nM Bioactivity Info	TI LI LO TS
CP0349201 Compound Info	[2-fluoro-5-methoxy-4-[[4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]phenyl]-morpholin-4-ylmethanone Show/Hide	C18H19F4N5O3	1
1	IC50 = 16 nM Bioactivity Info	TI LI LO TS
CP0301155 Compound Info	[5-[[4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]-4-methoxypyridin-2-yl]-morpholin-4-ylmethanone Show/Hide	C18H21F3N6O3	1
1	IC50 = 17 nM Bioactivity Info	TI LI LO TS
CP0089100 Compound Info	US9499542, 14 Show/Hide	C19H16N6	2
1	IC50 = 17 nM Bioactivity Info	TI LI LO TS
2	IC50 = 18 nM Bioactivity Info	TI LI LO TS
CP0058925 Compound Info	2-fluoro-3-(4-morpholin-4-yl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)benzonitrile Show/Hide	C17H14FN5O	1
1	IC50 = 20 nM Bioactivity Info	TI LI LO TS
CP0491719 Compound Info	[2,5-dimethoxy-4-[[4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]phenyl]-morpholin-4-ylmethanone Show/Hide	C19H22F3N5O4	1
1	IC50 = 21 nM Bioactivity Info	TI LI LO TS
CP0179672 Compound Info	5-[[4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]-2-(2-hydroxy-2-methylpropyl)-6-methoxy-3H-isoindol-1-one Show/Hide	C20H24F3N5O3	1
1	IC50 = 22 nM Bioactivity Info	TI LI LO TS
CP0301156 Compound Info	[5-chloro-2-methoxy-4-[[4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]phenyl]-morpholin-4-ylmethanone Show/Hide	C18H19ClF3N5O3	1
1	IC50 = 24 nM Bioactivity Info	TI LI LO TS
CP0088382 Compound Info	3-(4-morpholin-4-yl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)benzonitrile Show/Hide	C17H15N5O	1
1	IC50 = 25 nM Bioactivity Info	TI LI LO TS
CP0086179 Compound Info	[5-chloro-4-[[4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]-2-methoxyphenyl]-morpholin-4-ylmethanone Show/Hide	C19H21ClF3N5O3	1
1	IC50 = 27 nM Bioactivity Info	TI LI LO TS
CP0087577 Compound Info	2-N-(5-fluoro-2-methoxy-4-methylsulfonylphenyl)-4-N-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine Show/Hide	C14H14F4N4O3S	1
1	IC50 = 27 nM Bioactivity Info	TI LI LO TS
CP0155868 Compound Info	BDBM50396041 Show/Hide	C17H20ClN5O3	1
1	IC50 = 29 nM Bioactivity Info	TI LI LO TS
CP0339216 Compound Info	[2-fluoro-3-methoxy-4-[[4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]phenyl]-morpholin-4-ylmethanone Show/Hide	C18H19F4N5O3	1
1	IC50 = 35 nM Bioactivity Info	TI LI LO TS
CP0239078 Compound Info	[5-chloro-2-methyl-4-[[4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]phenyl]-morpholin-4-ylmethanone Show/Hide	C18H19ClF3N5O2	1
1	IC50 = 43 nM Bioactivity Info	TI LI LO TS
CP0335187 Compound Info	2-N-[4-methoxy-6-(oxan-4-yl)pyridin-3-yl]-4-N-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine Show/Hide	C17H20F3N5O2	1
1	IC50 = 51 nM Bioactivity Info	TI LI LO TS
CP0573473 Compound Info	4-amino-7-methyl-2-[[5-methyl-1-[(3S)-oxolan-3-yl]pyrazol-4-yl]amino]-6-[(2R)-2-methylpyrrolidin-1-yl]pyrrolo[2,3-d]pyrimidine-5-carbonitrile Show/Hide	C21H27N9O	2
1	IC50 = 51 nM Bioactivity Info	TI LI LO TS
2	IC50 = 140 nM Bioactivity Info	TI LI LO TS
CP0301157 Compound Info	[4-[(5-bromo-4-methoxypyrimidin-2-yl)amino]-3-methoxyphenyl]-morpholin-4-ylmethanone Show/Hide	C17H19BrN4O4	1
1	IC50 = 53 nM Bioactivity Info	TI LI LO TS
CP0260860 Compound Info	4-amino-2-[(3-chloro-1-methylpyrazol-4-yl)amino]-7-methyl-6-[(2R)-2-methylpyrrolidin-1-yl]pyrrolo[2,3-d]pyrimidine-5-carbonitrile Show/Hide	C17H20ClN9	2
1	IC50 = 54 nM Bioactivity Info	TI LI LO TS
2	IC50 = 190 nM Bioactivity Info	TI LI LO TS
CP0267368 Compound Info	[5-fluoro-2-methoxy-4-[[4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]phenyl]-morpholin-4-ylmethanone Show/Hide	C18H19F4N5O3	1
1	IC50 = 63 nM Bioactivity Info	TI LI LO TS
CP0179678 Compound Info	[4-[(5-chloro-4-methoxypyrimidin-2-yl)amino]-3-methoxyphenyl]-morpholin-4-ylmethanone Show/Hide	C17H19ClN4O4	1
1	IC50 = 69 nM Bioactivity Info	TI LI LO TS
CP0359719 Compound Info	US9499542, 22 Show/Hide	C18H15N7	2
1	IC50 = 70 nM Bioactivity Info	TI LI LO TS
2	IC50 = 90 nM Bioactivity Info	TI LI LO TS
CP0482714 Compound Info	6-[(1-methylpyrazol-3-yl)amino]-4-(6-methylpyridin-2-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile Show/Hide	C18H15N7	2
1	IC50 = 76 nM Bioactivity Info	TI LI LO TS
2	IC50 = 160 nM Bioactivity Info	TI LI LO TS
CP0576299 Compound Info	4-amino-7-methyl-2-[[5-methyl-1-[(3R)-oxolan-3-yl]pyrazol-4-yl]amino]-6-[(2R)-2-methylpyrrolidin-1-yl]pyrrolo[2,3-d]pyrimidine-5-carbonitrile Show/Hide	C21H27N9O	2
1	IC50 = 80 nM Bioactivity Info	TI LI LO TS
2	IC50 = 180 nM Bioactivity Info	TI LI LO TS
CP0260609 Compound Info	US9499542, 13 Show/Hide	C18H14N6	2
1	IC50 = 85 nM Bioactivity Info	TI LI LO TS
2	IC50 = 100 nM Bioactivity Info	TI LI LO TS
CP0085677 Compound Info	3-[4-(dimethylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile Show/Hide	C15H13N5	1
1	IC50 = 89 nM Bioactivity Info	TI LI LO TS
CP0475020 Compound Info	6-[(4-chloro-1-methylpyrazol-3-yl)amino]-4-(5-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile Show/Hide	C18H14ClN7	2
1	IC50 = 93 nM Bioactivity Info	TI LI LO TS
2	IC50 = 190 nM Bioactivity Info	TI LI LO TS
CP0417713 Compound Info	6-[(4-chloro-1-methylpyrazol-3-yl)amino]-4-(6-methylpyridin-2-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile Show/Hide	C18H14ClN7	2
1	IC50 = 94 nM Bioactivity Info	TI LI LO TS
2	IC50 = 110 nM Bioactivity Info	TI LI LO TS
CP0061269 Compound Info	2-N-[2-chloro-4-(1-methyltetrazol-5-yl)phenyl]-4-N-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine Show/Hide	C14H12ClF3N8	1
1	IC50 = 100 nM Bioactivity Info	TI LI LO TS
CP0169665 Compound Info	2-[2-methoxy-4-(morpholine-4-carbonyl)anilino]-4-(methylamino)pyrimidine-5-carbonitrile Show/Hide	C18H20N6O3	1
1	IC50 = 105 nM Bioactivity Info	TI LI LO TS
CP0334596 Compound Info	3-[4-[2-(cyanomethyl)morpholin-4-yl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile Show/Hide	C19H16N6O	1
1	IC50 = 117 nM Bioactivity Info	TI LI LO TS
CP0260867 Compound Info	4-amino-2-[(1,3-dimethylpyrazol-4-yl)amino]-7-methyl-6-[(2R)-2-methylpyrrolidin-1-yl]pyrrolo[2,3-d]pyrimidine-5-carbonitrile Show/Hide	C18H23N9	2
1	IC50 = 120 nM Bioactivity Info	TI LI LO TS
2	IC50 = 190 nM Bioactivity Info	TI LI LO TS
CP0355745 Compound Info	4-amino-2-[[1-(2-hydroxy-2-methylpropyl)-5-methylpyrazol-4-yl]amino]-7-methyl-6-[(2R)-2-methylpyrrolidin-1-yl]pyrrolo[2,3-d]pyrimidine-5-carbonitrile Show/Hide	C21H29N9O	2
1	IC50 = 120 nM Bioactivity Info	TI LI LO TS
2	IC50 = 280 nM Bioactivity Info	TI LI LO TS
CP0495255 Compound Info	4-amino-2-[[1-[(3-hydroxyoxetan-3-yl)methyl]-5-methylpyrazol-4-yl]amino]-7-methyl-6-[(2R)-2-methylpyrrolidin-1-yl]pyrrolo[2,3-d]pyrimidine-5-carbonitrile Show/Hide	C21H27N9O2	2
1	IC50 = 120 nM Bioactivity Info	TI LI LO TS
2	IC50 = 220 nM Bioactivity Info	TI LI LO TS
CP0058932 Compound Info	3-[4-[(2S)-2-methylmorpholin-4-yl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile Show/Hide	C18H17N5O	1
1	IC50 = 122 nM Bioactivity Info	TI LI LO TS
CP0189934 Compound Info	US9499542, 20 Show/Hide	C19H17N7	2
1	IC50 = 130 nM Bioactivity Info	TI LI LO TS
2	IC50 = 170 nM Bioactivity Info	TI LI LO TS
CP0475019 Compound Info	6-[(1-methylpyrazol-3-yl)amino]-4-(2-methylpyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile Show/Hide	C18H15N7	2
1	IC50 = 130 nM Bioactivity Info	TI LI LO TS
2	IC50 = 700 nM Bioactivity Info	TI LI LO TS
CP0085678 Compound Info	3-[4-[(2S)-2-(5-methyl-1,2,4-oxadiazol-3-yl)morpholin-4-yl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile Show/Hide	C20H17N7O2	1
1	IC50 = 133 nM Bioactivity Info	TI LI LO TS
CP0575556 Compound Info	4-amino-7-methyl-2-[[3-methyl-1-(oxetan-3-yl)pyrazol-4-yl]amino]-6-[(2R)-2-methylpyrrolidin-1-yl]pyrrolo[2,3-d]pyrimidine-5-carbonitrile Show/Hide	C20H25N9O	2
1	IC50 = 140 nM Bioactivity Info	TI LI LO TS
2	IC50 = 240 nM Bioactivity Info	TI LI LO TS
CP0090031 Compound Info	4-[5-(3-chlorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]morpholine Show/Hide	C16H15ClN4O	1
1	IC50 = 144 nM Bioactivity Info	TI LI LO TS
CP0461834 Compound Info	6-[(1,4-dimethylpyrazol-3-yl)amino]-4-(5-methylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile Show/Hide	C19H17N7	2
1	IC50 = 160 nM Bioactivity Info	TI LI LO TS
2	IC50 = 170 nM Bioactivity Info	TI LI LO TS
CP0575874 Compound Info	4-amino-2-[[1-(2-hydroxy-2-methylpropyl)-3-methylpyrazol-4-yl]amino]-7-methyl-6-[(2R)-2-methylpyrrolidin-1-yl]pyrrolo[2,3-d]pyrimidine-5-carbonitrile Show/Hide	C21H29N9O	2
1	IC50 = 180 nM Bioactivity Info	TI LI LO TS
2	IC50 = 280 nM Bioactivity Info	TI LI LO TS
CP0069322 Compound Info	3-(4-piperidin-1-yl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)benzonitrile Show/Hide	C18H17N5	1
1	IC50 = 182 nM Bioactivity Info	TI LI LO TS
CP0344358 Compound Info	4-amino-7-methyl-2-[[5-methyl-1-(oxetan-3-yl)pyrazol-4-yl]amino]-6-[(2R)-2-methylpyrrolidin-1-yl]pyrrolo[2,3-d]pyrimidine-5-carbonitrile Show/Hide	C20H25N9O	2
1	IC50 = 190 nM Bioactivity Info	TI LI LO TS
2	IC50 = 300 nM Bioactivity Info	TI LI LO TS
CP0283525 Compound Info	4-(5-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)morpholine Show/Hide	C16H16N4O	1
1	IC50 = 198 nM Bioactivity Info	TI LI LO TS
CP0114275 Compound Info	3-[4-[(3S)-3-methylpiperidin-1-yl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile Show/Hide	C19H19N5	1
1	IC50 = 210 nM Bioactivity Info	TI LI LO TS
CP0260591 Compound Info	US9499542, 23 Show/Hide	C19H17N7	2
1	IC50 = 210 nM Bioactivity Info	TI LI LO TS
2	IC50 = 580 nM Bioactivity Info	TI LI LO TS
CP0417634 Compound Info	6-[(4-chloro-1-methylpyrazol-3-yl)amino]-4-(2-methylpyridin-4-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile Show/Hide	C18H14ClN7	2
1	IC50 = 210 nM Bioactivity Info	TI LI LO TS
2	IC50 = 1300 nM Bioactivity Info	TI LI LO TS
CP0116372 Compound Info	4-[5-(5-methylpyridin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]morpholine Show/Hide	C16H17N5O	1
1	IC50 = 211 nM Bioactivity Info	TI LI LO TS
CP0334641 Compound Info	6-(5-chloro-2-methoxyphenyl)sulfanyl-3-(1-methylpyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazine Show/Hide	C16H13ClN6OS	1
1	IC50 = 245 nM Bioactivity Info	TI LI LO TS
CP0573477 Compound Info	4-amino-2-[[1-[(3-hydroxyoxetan-3-yl)methyl]-3-methylpyrazol-4-yl]amino]-7-methyl-6-[(2R)-2-methylpyrrolidin-1-yl]pyrrolo[2,3-d]pyrimidine-5-carbonitrile Show/Hide	C21H27N9O2	2
1	IC50 = 250 nM Bioactivity Info	TI LI LO TS
2	IC50 = 410 nM Bioactivity Info	TI LI LO TS
CP0578015 Compound Info	4-amino-2-[(1,5-dimethylpyrazol-4-yl)amino]-7-methyl-6-[(2R)-2-methylpyrrolidin-1-yl]pyrrolo[2,3-d]pyrimidine-5-carbonitrile Show/Hide	C18H23N9	2
1	IC50 = 260 nM Bioactivity Info	TI LI LO TS
2	IC50 = 310 nM Bioactivity Info	TI LI LO TS
CP0090033 Compound Info	4-[5-(1-methylpyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]morpholine Show/Hide	C14H16N6O	1
1	IC50 = 278 nM Bioactivity Info	TI LI LO TS
CP0069326 Compound Info	6-(4-morpholin-4-yl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)pyridine-2-carbonitrile Show/Hide	C16H14N6O	1
1	IC50 = 298 nM Bioactivity Info	TI LI LO TS
CP0069325 Compound Info	3-[4-[(2R)-2-methylmorpholin-4-yl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile Show/Hide	C18H17N5O	1
1	IC50 = 377 nM Bioactivity Info	TI LI LO TS
CP0052255 Compound Info	6-(2,5-dimethoxyphenyl)sulfanyl-3-(1-methylpyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazine Show/Hide	C17H16N6O2S	1
1	IC50 = 387 nM Bioactivity Info	TI LI LO TS
CP0069330 Compound Info	3-[4-[2-(3-methyl-1,2,4-oxadiazol-5-yl)morpholin-4-yl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile Show/Hide	C20H17N7O2	1
1	IC50 = 390 nM Bioactivity Info	TI LI LO TS
CP0052244 Compound Info	6-(2,5-dimethoxyphenyl)sulfanyl-3-(1-methylpyrazol-4-yl)imidazo[1,2-b]pyridazine Show/Hide	C18H17N5O2S	1
1	IC50 = 400 nM Bioactivity Info	TI LI LO TS
CP0087686 Compound Info	[4-[[5-fluoro-4-(methylamino)pyrimidin-2-yl]amino]-3-methoxyphenyl]-morpholin-4-ylmethanone Show/Hide	C17H20FN5O3	1
1	IC50 = 418 nM Bioactivity Info	TI LI LO TS
CP0090032 Compound Info	3-(4-pyrrolidin-1-yl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)benzonitrile Show/Hide	C17H15N5	1
1	IC50 = 432 nM Bioactivity Info	TI LI LO TS
CP0480455 Compound Info	6-(2,5-dimethoxyphenyl)sulfanyl-3-(5-methoxypyridin-3-yl)-[1,2,4]triazolo[4,3-b]pyridazine Show/Hide	C19H17N5O3S	1
1	IC50 = 440 nM Bioactivity Info	TI LI LO TS
CP0069328 Compound Info	3-[4-(diethylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile Show/Hide	C17H17N5	1
1	IC50 = 443 nM Bioactivity Info	TI LI LO TS
CP0344357 Compound Info	4-amino-7-methyl-6-[(2R)-2-methylpyrrolidin-1-yl]-2-[[1-methyl-3-(trifluoromethyl)pyrazol-4-yl]amino]pyrrolo[2,3-d]pyrimidine-5-carbonitrile Show/Hide	C18H20F3N9	2
1	IC50 = 460 nM Bioactivity Info	TI LI LO TS
2	IC50 = 910 nM Bioactivity Info	TI LI LO TS
CP0052243 Compound Info	5-(2,5-dimethoxyphenyl)sulfanyl-3-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyrimidine Show/Hide	C18H17N5O2S	1
1	IC50 = 488 nM Bioactivity Info	TI LI LO TS
CP0379031 Compound Info	5-[6-(2,5-dimethoxyphenyl)sulfanyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]-1,3-thiazole Show/Hide	C16H13N5O2S2	1
1	IC50 = 660 nM Bioactivity Info	TI LI LO TS
CP0143156 Compound Info	5-[6-(3-bromophenyl)sulfanyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]-1,3-thiazole Show/Hide	C14H8BrN5S2	1
1	IC50 = 683 nM Bioactivity Info	TI LI LO TS
CP0302713 Compound Info	3-[6-(2,5-dimethoxyphenyl)sulfanyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]-1,2-thiazole Show/Hide	C16H13N5O2S2	1
1	IC50 = 722 nM Bioactivity Info	TI LI LO TS
CP0245491 Compound Info	6-(2,5-dimethoxyphenyl)sulfanyl-3-pyridin-3-yl-[1,2,4]triazolo[4,3-b]pyridazine Show/Hide	C18H15N5O2S	1
1	IC50 = 736 nM Bioactivity Info	TI LI LO TS
CP0052242 Compound Info	5-(2,5-dimethoxyphenyl)sulfanyl-2-methyl-3-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyrimidine Show/Hide	C19H19N5O2S	1
1	IC50 = 759 nM Bioactivity Info	TI LI LO TS
CP0323240 Compound Info	5-[6-[3-(trifluoromethyl)phenyl]sulfanyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]-1,3-thiazole Show/Hide	C15H8F3N5S2	1
1	IC50 = 780 nM Bioactivity Info	TI LI LO TS
CP0069327 Compound Info	4-[5-(3-methoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]morpholine Show/Hide	C17H18N4O2	1
1	IC50 = 882 nM Bioactivity Info	TI LI LO TS
CP0419192 Compound Info	6-(2,5-dimethoxyphenyl)sulfanyl-2-methyl-3-(1-methylpyrazol-4-yl)imidazo[1,2-b]pyridazine Show/Hide	C19H19N5O2S	1
1	IC50 = 945 nM Bioactivity Info	TI LI LO TS
CP0231675 Compound Info	3-(1H-pyrazol-5-yl)-6-[3-(trifluoromethyl)phenyl]sulfanyl-[1,2,4]triazolo[4,3-b]pyridazine Show/Hide	C15H9F3N6S	1
1	IC50 = 1016 nM Bioactivity Info	TI LI LO TS
CP0322344 Compound Info	6-(2,5-dimethoxyphenyl)sulfanyl-3-(1,3-dimethylpyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazine Show/Hide	C18H18N6O2S	1
1	IC50 = 1260 nM Bioactivity Info	TI LI LO TS
CP0131134 Compound Info	6-(2,5-dimethoxyphenyl)sulfanyl-3-pyridin-2-yl-[1,2,4]triazolo[4,3-b]pyridazine Show/Hide	C18H15N5O2S	1
1	IC50 = 1310 nM Bioactivity Info	TI LI LO TS
CP0090034 Compound Info	4-[5-(3-cyanophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]morpholine-2-carbonitrile Show/Hide	C18H14N6O	1
1	IC50 = 1331 nM Bioactivity Info	TI LI LO TS
CP0064440 Compound Info	6-(2,5-dimethoxyphenyl)sulfanyl-3-phenyl-[1,2,4]triazolo[4,3-b]pyridazine Show/Hide	C19H16N4O2S	1
1	IC50 = 1380 nM Bioactivity Info	TI LI LO TS
CP0231666 Compound Info	5-[6-(3-tert-butylphenyl)sulfanyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]-1,3-thiazole Show/Hide	C18H17N5S2	1
1	IC50 = 1393 nM Bioactivity Info	TI LI LO TS
CP0231673 Compound Info	5-[6-(3-chlorophenyl)sulfanyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]-1,3-thiazole Show/Hide	C14H8ClN5S2	1
1	IC50 = 1397 nM Bioactivity Info	TI LI LO TS
CP0280003 Compound Info	3-[4-[2-(1,2-oxazol-5-yl)morpholin-4-yl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile Show/Hide	C20H16N6O2	1
1	IC50 = 1467 nM Bioactivity Info	TI LI LO TS
CP0069329 Compound Info	3-[4-[(3R)-3-methylpiperidin-1-yl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile Show/Hide	C19H19N5	1
1	IC50 = 1579 nM Bioactivity Info	TI LI LO TS
CP0174414 Compound Info	3-thiophen-2-yl-6-[3-(trifluoromethyl)phenyl]sulfanyl-[1,2,4]triazolo[4,3-b]pyridazine Show/Hide	C16H9F3N4S2	1
1	IC50 = 1656 nM Bioactivity Info	TI LI LO TS
CP0184836 Compound Info	2-[6-[3-(trifluoromethyl)phenyl]sulfanyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]-1,3-thiazole Show/Hide	C15H8F3N5S2	1
1	IC50 = 1727 nM Bioactivity Info	TI LI LO TS
CP0334639 Compound Info	6-(2,5-dimethoxyphenoxy)-3-phenyl-[1,2,4]triazolo[4,3-b]pyridazine Show/Hide	C19H16N4O3	1
1	IC50 = 1740 nM Bioactivity Info	TI LI LO TS
CP0489450 Compound Info	6-(2,5-dichlorophenyl)sulfanyl-3-(1-methylpyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazine Show/Hide	C15H10Cl2N6S	1
1	IC50 = 1800 nM Bioactivity Info	TI LI LO TS
CP0052246 Compound Info	4-methoxy-3-[[3-(1-methylpyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]sulfanyl]benzonitrile Show/Hide	C17H13N7OS	1
1	IC50 = 2070 nM Bioactivity Info	TI LI LO TS
CP0310490 Compound Info	3-fluoro-5-(4-morpholin-4-yl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)benzonitrile Show/Hide	C17H14FN5O	1
1	IC50 = 2082 nM Bioactivity Info	TI LI LO TS
CP0184815 Compound Info	4-[6-[3-(trifluoromethyl)phenyl]sulfanyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]-1,3-thiazole Show/Hide	C15H8F3N5S2	1
1	IC50 = 2112 nM Bioactivity Info	TI LI LO TS
CP0317166 Compound Info	2-fluoro-5-(4-morpholin-4-yl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)benzonitrile Show/Hide	C17H14FN5O	1
1	IC50 = 2460 nM Bioactivity Info	TI LI LO TS
CP0085676 Compound Info	4-[5-(1-methylpyrazol-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]morpholine Show/Hide	C14H16N6O	1
1	IC50 = 2570 nM Bioactivity Info	TI LI LO TS
CP0248426 Compound Info	6-(2,5-dimethoxyphenyl)sulfanyl-3-(1-methylpyrazol-3-yl)-[1,2,4]triazolo[4,3-b]pyridazine Show/Hide	C17H16N6O2S	1
1	IC50 = 2760 nM Bioactivity Info	TI LI LO TS
CP0174408 Compound Info	2-[(3-thiophen-2-yl-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)sulfanyl]propanamide Show/Hide	C12H11N5OS2	1
1	IC50 = 3032 nM Bioactivity Info	TI LI LO TS
CP0090035 Compound Info	3-[4-(1,3,3a,4,6,6a-hexahydrofuro[3,4-c]pyrrol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile Show/Hide	C19H17N5O	1
1	IC50 = 3363 nM Bioactivity Info	TI LI LO TS
CP0069323 Compound Info	3-[4-(2,3,3a,4,6,6a-hexahydrofuro[2,3-c]pyrrol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile Show/Hide	C19H17N5O	1
1	IC50 = 3694 nM Bioactivity Info	TI LI LO TS
CP0476051 Compound Info	3-[6-(2,5-dimethoxyphenyl)sulfanyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]-1,2-oxazole Show/Hide	C16H13N5O3S	1
1	IC50 = 4330 nM Bioactivity Info	TI LI LO TS
CP0131136 Compound Info	5-(2,5-dimethoxyphenyl)sulfanyl-3-(1-methylpyrazol-4-yl)triazolo[4,5-b]pyridine Show/Hide	C17H16N6O2S	1
1	IC50 = 5240 nM Bioactivity Info	TI LI LO TS
CP0237765 Compound Info	5-(2,5-dimethoxyphenyl)sulfanyl-3-(1-methylpyrazol-4-yl)imidazo[4,5-b]pyridine Show/Hide	C18H17N5O2S	1
1	IC50 = 5850 nM Bioactivity Info	TI LI LO TS
CP0085675 Compound Info	3-[4-(azetidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile Show/Hide	C16H13N5	1
1	IC50 = 7687 nM Bioactivity Info	TI LI LO TS
CP0169053 Compound Info	4-[[[5-bromo-2-[[3-methyl-1-(2,2,2-trifluoroethyl)pyrazol-4-yl]amino]pyrimidin-4-yl]amino]methyl]benzenesulfonamide Show/Hide	C17H17BrF3N7O2S	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS
CP0275674 Compound Info	5-cyclopropyl-4-N-[2-(1H-imidazol-5-yl)ethyl]-2-N-[3-methyl-1-(2,2,2-trifluoroethyl)pyrazol-4-yl]pyrimidine-2,4-diamine Show/Hide	C18H21F3N8	1
1	IC50 > 10000 nM Bioactivity Info	TI LI LO TS

Cell Line ID: CL000025 , HEK-293T

Cell Line Info

Cell Line ID: CL000132 , NK-92

Cell Line Info

Cell Line ID: CL000013 , Sf9

Cell Line Info

Cell Line ID: CL000004 , SH-SY5Y

Cell Line Info

Biochemical Assays

Compound ID	Compound Name	Compound Formula
CP0644312 Compound Info	cis-2,6-Dimethyl-4-(6-(5-(1-methylcyclopropoxy)-1H-indazol-3-yl)pyrimidin-4-yl)morpholine Show/Hide	C21H25N5O2	8
1	EC50 ~ 1.22 nM
2	IC50 = 0.4 nM
3	IC50 = 0.5 nM
4	IC50 = 0.76 nM
5	IC50 = 1 nM
6	IC50 ~ 1.8 nM
7	IC50 ~ 3.5 nM
8	IC50 ~ 6.3 nM
CP0141818 Compound Info	[3-(difluoromethoxy)-4-[(4-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino]phenyl]-(4-methylpiperazin-1-yl)methanone Show/Hide	C21H24F2N6O3	1
1	IC50 < 0.1585 nM
CP0019734 Compound Info	4-(propan-2-ylamino)-6-(1H-pyrazol-4-yl)cinnoline-3-carboxamide Show/Hide	C15H16N6O	2
1	IC50 = 1 nM
2	IC50 = 5 nM
CP0023856 Compound Info	4-[[(1R)-1-cyclopropylethyl]amino]-7-(4-methylsulfonylphenyl)cinnoline-3-carboxamide Show/Hide	C21H22N4O3S	2
1	IC50 = 1 nM
2	IC50 = 7 nM
CP0067767 Compound Info	4-[[(2R)-butan-2-yl]amino]-7-(4-methylsulfonylphenyl)cinnoline-3-carboxamide Show/Hide	C20H22N4O3S	2
1	IC50 = 1 nM
2	IC50 = 4 nM
CP0357679 Compound Info	N-[2-[(3R)-3-(2-hydroxypropan-2-yl)pyrrolidin-1-yl]-5-(trifluoromethyl)pyridin-4-yl]-6-(1-methylpyrazol-4-yl)pyridine-2-carboxamide Show/Hide	C23H25F3N6O2	1
1	IC50 = 1 nM
CP0033205 Compound Info	(5R)-5-[[3-(2-methylpyridin-4-yl)-1H-indazol-5-yl]amino]-5,6,7,8-tetrahydronaphthalene-2-carbonitrile Show/Hide	C24H21N5	2
1	IC50 < 1 nM
2	IC50 = 14 nM
CP0033544 Compound Info	2-[[3-(2-methylpyridin-4-yl)-1H-indazol-5-yl]amino]benzonitrile Show/Hide	C20H15N5	2
1	IC50 = 1 nM
2	IC50 = 5 nM
CP0546499 Compound Info	(5S)-5-[[3-(2,6-dimethylpyridin-4-yl)-1H-indazol-5-yl]amino]-5,6,7,8-tetrahydronaphthalene-2-carbonitrile Show/Hide	C25H23N5	2
1	IC50 < 1 nM
2	IC50 = 11 nM
CP0564501 Compound Info	(5S)-5-[[3-(2-methylpyridin-4-yl)-1H-indazol-5-yl]amino]-5,6,7,8-tetrahydronaphthalene-2-carbonitrile Show/Hide	C24H21N5	2
1	IC50 < 1 nM
2	IC50 = 8 nM
CP0572904 Compound Info	(5S)-5-[[3-(2-morpholin-4-ylpyridin-4-yl)-1H-indazol-5-yl]amino]-5,6,7,8-tetrahydronaphthalene-2-carbonitrile Show/Hide	C27H26N6O	2
1	IC50 < 1 nM
2	IC50 = 8 nM
CP0218399 Compound Info	4-[[(1R)-1-cyclopropylethyl]amino]-7-pyridin-4-ylcinnoline-3-carboxamide Show/Hide	C19H19N5O	3
1	IC50 = 2 nM
2	IC50 = 6 nM
3	IC50 <= 6 nM
CP0535015 Compound Info	N-[2-[(2R,3S)-3-hydroxy-2-methylazetidin-1-yl]-5-(trifluoromethyl)pyridin-4-yl]-6-(1-methylpyrazol-4-yl)pyridine-2-carboxamide Show/Hide	C20H19F3N6O2	1
1	IC50 = 2 nM
CP0564492 Compound Info	3-fluoro-2-[(3-pyridin-4-yl-1H-indazol-5-yl)amino]benzonitrile Show/Hide	C19H12FN5	2
1	IC50 = 2 nM
2	IC50 = 10 nM
CP0568003 Compound Info	4-[[3-(2-methylpyridin-4-yl)-1H-indazol-5-yl]amino]benzene-1,3-dicarbonitrile Show/Hide	C21H14N6	2
1	IC50 = 2 nM
2	IC50 = 7 nM
CP0579368 Compound Info	(5R)-5-[[3-(2-morpholin-4-ylpyridin-4-yl)-1H-indazol-5-yl]amino]-5,6,7,8-tetrahydronaphthalene-2-carbonitrile Show/Hide	C27H26N6O	2
1	IC50 = 2 nM
2	IC50 = 30 nM
CP0058925 Compound Info	2-fluoro-3-(4-morpholin-4-yl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)benzonitrile Show/Hide	C17H14FN5O	2
1	IC50 = 3 nM
2	IC50 = 9 nM
CP0088382 Compound Info	3-(4-morpholin-4-yl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)benzonitrile Show/Hide	C17H15N5O	3
1	IC50 = 3 nM
2	IC50 = 11 nM
3	IC50 = 15 nM
CP0570264 Compound Info	(5S)-5-[(3-pyridin-4-yl-1H-indazol-5-yl)amino]-5,6,7,8-tetrahydronaphthalene-2-carbonitrile Show/Hide	C23H19N5	2
1	IC50 = 3 nM
2	IC50 = 40 nM
CP0577522 Compound Info	2-[[3-(2-methoxypyridin-4-yl)-1H-indazol-5-yl]amino]benzonitrile Show/Hide	C20H15N5O	2
1	IC50 = 3 nM
2	IC50 = 21 nM
CP0899198 Compound Info	(S)-(4-((4-Ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxyphenyl)(hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl)methanone Show/Hide	C23H28N6O3	1
1	IC50 = 3.162 nM
CP0083561 Compound Info	BDBM50379529 Show/Hide	C31H38N8O3	4
1	IC50 = 3.5 nM
2	IC50 = 6 nM
3	IC50 = 13 nM
4	Ki = 6 nM
CP0357657 Compound Info	N-[2-[(2S,6R)-2,6-dimethylmorpholin-4-yl]-5-(trifluoromethyl)pyridin-4-yl]-6-(1-methylpyrazol-4-yl)pyridine-2-carboxamide Show/Hide	C22H23F3N6O2	1
1	IC50 = 4 nM
CP0571039 Compound Info	N-[6-[(3R)-3-(2-hydroxypropan-2-yl)pyrrolidin-1-yl]-2-methylpyrimidin-4-yl]-6-(1-methylpyrazol-4-yl)pyridine-2-carboxamide Show/Hide	C22H27N7O2	1
1	IC50 = 4 nM
CP0543315 Compound Info	(4R)-4-[[3-(2,6-dimethylpyridin-4-yl)-1H-indazol-5-yl]amino]-3,4-dihydro-2H-chromene-7-carbonitrile Show/Hide	C24H21N5O	2
1	IC50 = 4 nM
2	IC50 = 42 nM
CP0564488 Compound Info	4-[(3-pyridin-4-yl-1H-indazol-5-yl)amino]-3,4-dihydro-2H-chromene-7-carbonitrile Show/Hide	C22H17N5O	2
1	IC50 = 4 nM
2	IC50 = 61 nM
CP0568096 Compound Info	N-(2-nitrophenyl)-3-pyridin-4-yl-1H-indazol-5-amine Show/Hide	C18H13N5O2	2
1	IC50 = 4 nM
2	IC50 = 24 nM
CP0568097 Compound Info	2-[(3-pyridin-4-yl-1H-indazol-5-yl)amino]benzonitrile Show/Hide	C19H13N5	2
1	IC50 = 4 nM
2	IC50 = 19 nM
CP0568785 Compound Info	(5R)-5-[[3-(2,6-dimethylpyridin-4-yl)-1H-indazol-5-yl]amino]-5,6,7,8-tetrahydronaphthalene-2-carbonitrile Show/Hide	C25H23N5	2
1	IC50 = 4 nM
2	IC50 = 35 nM
CP0535014 Compound Info	N-[2-(3-hydroxyazetidin-1-yl)-5-(trifluoromethyl)pyridin-4-yl]-6-(1-methylpyrazol-4-yl)pyridine-2-carboxamide Show/Hide	C19H17F3N6O2	1
1	IC50 = 4.8 nM
CP0019820 Compound Info	7-(1-methylpyrazol-4-yl)-4-(propan-2-ylamino)quinoline-3-carbonitrile Show/Hide	C17H17N5	2
1	IC50 = 5 nM
2	IC50 = 7 nM
CP0085677 Compound Info	3-[4-(dimethylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile Show/Hide	C15H13N5	3
1	IC50 = 5 nM
2	IC50 = 15 nM
3	IC50 = 42 nM
CP0334596 Compound Info	3-[4-[2-(cyanomethyl)morpholin-4-yl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile Show/Hide	C19H16N6O	1
1	IC50 = 5 nM
CP0575973 Compound Info	N-[2-[(2R,3R)-3-hydroxy-2-methylpyrrolidin-1-yl]-5-(trifluoromethyl)pyridin-4-yl]-6-(1-methylpyrazol-4-yl)pyridine-2-carboxamide Show/Hide	C21H21F3N6O2	1
1	IC50 = 5 nM
CP0572902 Compound Info	2-fluoro-6-[(3-pyridin-4-yl-1H-indazol-5-yl)amino]benzonitrile Show/Hide	C19H12FN5	2
1	IC50 = 5 nM
2	IC50 = 22 nM
CP0574429 Compound Info	1-[(3-pyridin-4-yl-1H-indazol-5-yl)amino]-2,3-dihydro-1H-indene-5-carbonitrile Show/Hide	C22H17N5	2
1	IC50 = 5 nM
2	IC50 = 40 nM
CP0321712 Compound Info	4-[3-cyano-4-(propan-2-ylamino)quinolin-7-yl]-N-methylbenzenesulfonamide Show/Hide	C20H20N4O2S	2
1	IC50 = 6 nM
2	IC50 = 9 nM
CP0143156 Compound Info	5-[6-(3-bromophenyl)sulfanyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]-1,3-thiazole Show/Hide	C14H8BrN5S2	2
1	IC50 = 6 nM
2	IC50 = 32 nM
CP0069322 Compound Info	3-(4-piperidin-1-yl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)benzonitrile Show/Hide	C18H17N5	2
1	IC50 = 6 nM
2	IC50 = 28 nM
CP0094235 Compound Info	5-(4-methylpiperazin-1-yl)-2-phenylmethoxy-N-pyridin-3-ylbenzamide Show/Hide	C24H26N4O2	1
1	IC50 = 6 nM
CP0031119 Compound Info	4-[(3-pyridin-4-yl-1H-indazol-5-yl)amino]benzene-1,3-dicarbonitrile Show/Hide	C20H12N6	2
1	IC50 = 6 nM
2	IC50 = 34 nM
CP0545147 Compound Info	5-methyl-2-[(3-pyridin-4-yl-1H-indazol-5-yl)amino]benzonitrile Show/Hide	C20H15N5	2
1	IC50 = 6 nM
2	IC50 = 18 nM
CP0031120 Compound Info	3-nitro-4-[(3-pyridin-4-yl-1H-indazol-5-yl)amino]benzonitrile Show/Hide	C19H12N6O2	2
1	IC50 = 6.2 nM
2	IC50 = 23 nM
CP0322693 Compound Info	[4-[(4-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino]-3-methoxyphenyl]-(2-methyl-2,7-diazaspiro[3.5]nonan-7-yl)methanone Show/Hide	C24H30N6O3	1
1	IC50 = 6.31 nM
CP0537119 Compound Info	[4-[(4-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino]-3-methoxyphenyl]-(4-fluoropiperidin-1-yl)methanone Show/Hide	C21H24FN5O3	1
1	IC50 = 6.31 nM
CP0058932 Compound Info	3-[4-[(2S)-2-methylmorpholin-4-yl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile Show/Hide	C18H17N5O	1
1	IC50 = 7 nM
CP0546878 Compound Info	5-methoxy-2-[(3-pyridin-4-yl-1H-indazol-5-yl)amino]benzonitrile Show/Hide	C20H15N5O	2
1	IC50 = 7 nM
2	IC50 = 22 nM
CP0072337 Compound Info	2-[(4-fluorophenyl)methoxy]-N-pyridin-3-yl-5-(trifluoromethyl)benzamide Show/Hide	C20H14F4N2O2	2
1	IC50 = 7.943 nM
2	IC50 = 19.95 nM
CP0353350 Compound Info	[4-[(4-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino]phenyl]-morpholin-4-ylmethanone Show/Hide	C19H21N5O3	1
1	IC50 = 7.943 nM
CP0807578 Compound Info	(S)-(4-((4-Ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxyphenyl)(3-methylmorpholino)methanone Show/Hide	C21H25N5O4	1
1	IC50 = 7.943 nM
CP0838494 Compound Info	(R)-(4-((4-Ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxyphenyl)(hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl)methanone Show/Hide	C23H28N6O3	1
1	IC50 = 7.943 nM
CP0231673 Compound Info	5-[6-(3-chlorophenyl)sulfanyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]-1,3-thiazole Show/Hide	C14H8ClN5S2	2
1	IC50 = 8 nM
2	IC50 = 31 nM
CP0085678 Compound Info	3-[4-[(2S)-2-(5-methyl-1,2,4-oxadiazol-3-yl)morpholin-4-yl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile Show/Hide	C20H17N7O2	1
1	IC50 = 8 nM
CP0090031 Compound Info	4-[5-(3-chlorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]morpholine Show/Hide	C16H15ClN4O	2
1	IC50 = 8 nM
2	IC50 = 13 nM
CP0090032 Compound Info	3-(4-pyrrolidin-1-yl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)benzonitrile Show/Hide	C17H15N5	2
1	IC50 = 8 nM
2	IC50 = 64 nM
CP0577559 Compound Info	N-[5-[(3R)-3-(2-hydroxypropan-2-yl)pyrrolidin-1-yl]-2-(trifluoromethyl)pyridin-3-yl]-6-[1-[[1-(trifluoromethyl)cyclopropyl]methyl]pyrazol-4-yl]pyridine-2-carboxamide Show/Hide	C27H28F6N6O2	1
1	IC50 = 8 nM
CP0564486 Compound Info	3-methyl-2-[(3-pyridin-4-yl-1H-indazol-5-yl)amino]benzonitrile Show/Hide	C20H15N5	2
1	IC50 = 8 nM
2	IC50 = 25 nM
CP0564491 Compound Info	2-[(3-pyridin-4-yl-1H-indazol-5-yl)oxy]benzonitrile Show/Hide	C19H12N4O	2
1	IC50 = 8 nM
2	IC50 = 20 nM
CP0573657 Compound Info	(4R)-4-[(3-pyridin-4-yl-1H-indazol-5-yl)amino]-3,4-dihydro-2H-chromene-7-carbonitrile Show/Hide	C22H17N5O	2
1	IC50 = 8 nM
2	IC50 = 189 nM
CP0573659 Compound Info	2-methyl-6-[(3-pyridin-4-yl-1H-indazol-5-yl)amino]benzonitrile Show/Hide	C20H15N5	2
1	IC50 = 8 nM
2	IC50 = 38 nM
CP0357660 Compound Info	6-[1-(cyclopropylmethyl)pyrazol-4-yl]-N-[5-[(3R)-3-(2-hydroxypropan-2-yl)pyrrolidin-1-yl]-2-(trifluoromethyl)pyridin-3-yl]pyridine-2-carboxamide Show/Hide	C26H29F3N6O2	1
1	IC50 = 8.6 nM
CP0069326 Compound Info	6-(4-morpholin-4-yl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)pyridine-2-carbonitrile Show/Hide	C16H14N6O	2
1	IC50 = 9 nM
2	IC50 = 26 nM
CP0283525 Compound Info	4-(5-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)morpholine Show/Hide	C16H16N4O	2
1	IC50 = 9 nM
2	IC50 = 14 nM
CP0357658 Compound Info	N-[2-[4-(2-hydroxypropan-2-yl)-2-azabicyclo[2.1.1]hexan-2-yl]-5-(trifluoromethyl)pyridin-4-yl]-6-(1-methylpyrazol-4-yl)pyridine-2-carboxamide Show/Hide	C24H25F3N6O2	1
1	IC50 = 9 nM
CP0535011 Compound Info	N-[2-[(2S,6R)-2,6-dimethylmorpholin-4-yl]-5-methylpyridin-4-yl]-6-(1-methylpyrazol-4-yl)pyridine-2-carboxamide Show/Hide	C22H26N6O2	1
1	IC50 = 9 nM
CP0543316 Compound Info	(5R)-5-[(3-pyridin-4-yl-1H-indazol-5-yl)amino]-5,6,7,8-tetrahydronaphthalene-2-carbonitrile Show/Hide	C23H19N5	2
1	IC50 = 9 nM
2	IC50 = 115 nM
CP0077182 Compound Info	7-(4-morpholin-4-ylsulfonylphenyl)-4-(propan-2-ylamino)quinoline-3-carbonitrile Show/Hide	C23H24N4O3S	2
1	IC50 = 10 nM
2	IC50 = 14 nM
CP0114881 Compound Info	4-(azetidin-1-yl)-7-(1-methylpyrazol-4-yl)quinoline-3-carbonitrile Show/Hide	C17H15N5	2
1	IC50 = 10 nM
2	IC50 = 13 nM
CP0507459 Compound Info	[4-[(4-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino]-3-propan-2-yloxyphenyl]-(4-methylpiperazin-1-yl)methanone Show/Hide	C23H30N6O3	1
1	IC50 = 10 nM
CP0507460 Compound Info	[3-ethoxy-4-[(4-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino]phenyl]-(4-methylpiperazin-1-yl)methanone Show/Hide	C22H28N6O3	1
1	IC50 = 10 nM
CP0549589 Compound Info	[3-ethoxy-4-[(4-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino]phenyl]-morpholin-4-ylmethanone Show/Hide	C21H25N5O4	1
1	IC50 = 10 nM
CP0495255 Compound Info	4-amino-2-[[1-[(3-hydroxyoxetan-3-yl)methyl]-5-methylpyrazol-4-yl]amino]-7-methyl-6-[(2R)-2-methylpyrrolidin-1-yl]pyrrolo[2,3-d]pyrimidine-5-carbonitrile Show/Hide	C21H27N9O2	2
1	IC50 = 10 nM
2	IC50 = 16 nM
CP0571036 Compound Info	N-[5-[(3R)-3-(2-hydroxypropan-2-yl)pyrrolidin-1-yl]-2-(trifluoromethyl)pyridin-3-yl]-6-[1-(2,2,2-trifluoroethyl)pyrazol-4-yl]pyridine-2-carboxamide Show/Hide	C24H24F6N6O2	1
1	IC50 = 10 nM
CP0577652 Compound Info	3-nitro-4-[(3-pyridin-4-yl-1H-indazol-5-yl)oxy]benzonitrile Show/Hide	C19H11N5O3	2
1	IC50 = 10 nM
2	IC50 = 26 nM
CP0546879 Compound Info	2-methyl-3-[[(3-pyridin-4-yl-1H-indazol-5-yl)amino]methyl]benzonitrile Show/Hide	C21H17N5	2
1	IC50 = 11 nM
2	IC50 = 82 nM
CP0090033 Compound Info	4-[5-(1-methylpyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]morpholine Show/Hide	C14H16N6O	3
1	IC50 = 12 nM
2	IC50 = 36 nM
3	IC50 = 50 nM
CP0576299 Compound Info	4-amino-7-methyl-2-[[5-methyl-1-[(3R)-oxolan-3-yl]pyrazol-4-yl]amino]-6-[(2R)-2-methylpyrrolidin-1-yl]pyrrolo[2,3-d]pyrimidine-5-carbonitrile Show/Hide	C21H27N9O	2
1	IC50 = 12 nM
2	IC50 = 20 nM
CP0550091 Compound Info	(5R)-5-[[3-(1-methylpyrazol-4-yl)-1H-indazol-5-yl]amino]-5,6,7,8-tetrahydronaphthalene-2-carbonitrile Show/Hide	C22H20N6	2
1	IC50 = 12 nM
2	IC50 = 69 nM
CP0031357 Compound Info	[4-[(4-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino]-3-methoxyphenyl]-morpholin-4-ylmethanone Show/Hide	C20H23N5O4	1
1	IC50 = 12.59 nM
CP0425397 Compound Info	4-[(4-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino]-N-(2-hydroxy-2-methylpropyl)-3-methoxybenzamide Show/Hide	C20H25N5O4	1
1	IC50 = 12.59 nM
CP0517316 Compound Info	[3-chloro-4-[(4-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino]phenyl]-(4-methylpiperazin-1-yl)methanone Show/Hide	C20H23ClN6O2	1
1	IC50 = 12.59 nM
CP0532672 Compound Info	4-[[4-(2,2,2-trifluoroethylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]benzamide Show/Hide	C15H13F3N6O	1
1	IC50 = 12.59 nM
CP0553334 Compound Info	[4-[(4-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino]-3-fluorophenyl]-(4-methylpiperazin-1-yl)methanone Show/Hide	C20H23FN6O2	1
1	IC50 = 12.59 nM
CP0557934 Compound Info	[4-[(4-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino]phenyl]-(4-methylpiperazin-1-yl)methanone Show/Hide	C20H24N6O2	1
1	IC50 = 12.59 nM
CP0561897 Compound Info	[4-[(4-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino]-3-propan-2-yloxyphenyl]-morpholin-4-ylmethanone Show/Hide	C22H27N5O4	1
1	IC50 = 12.59 nM
CP0231675 Compound Info	3-(1H-pyrazol-5-yl)-6-[3-(trifluoromethyl)phenyl]sulfanyl-[1,2,4]triazolo[4,3-b]pyridazine Show/Hide	C15H9F3N6S	2
1	IC50 = 13 nM
2	IC50 = 53 nM
CP0543313 Compound Info	5-fluoro-2-[(3-pyridin-4-yl-1H-indazol-5-yl)amino]benzonitrile Show/Hide	C19H12FN5	2
1	IC50 = 13 nM
2	IC50 = 56 nM
CP0233613 Compound Info	4-(propan-2-ylamino)-7-(1,2-thiazol-4-yl)cinnoline-3-carboxamide Show/Hide	C15H15N5OS	2
1	IC50 = 14 nM
2	IC50 = 20 nM
CP0573473 Compound Info	4-amino-7-methyl-2-[[5-methyl-1-[(3S)-oxolan-3-yl]pyrazol-4-yl]amino]-6-[(2R)-2-methylpyrrolidin-1-yl]pyrrolo[2,3-d]pyrimidine-5-carbonitrile Show/Hide	C21H27N9O	2
1	IC50 = 14 nM
2	IC50 = 23 nM
CP0573705 Compound Info	N-(1-cyclobutylpyrazol-4-yl)-2-(1-methylpyrazol-4-yl)-1,3-thiazole-4-carboxamide Show/Hide	C15H16N6OS	1
1	IC50 = 14 nM
CP0022216 Compound Info	4-(propan-2-ylamino)-7-pyridin-4-ylcinnoline-3-carboxamide Show/Hide	C17H17N5O	2
1	IC50 = 15 nM
2	IC50 = 16 nM
CP0067768 Compound Info	7-(4-methylsulfonylphenyl)-4-(propan-2-ylamino)cinnoline-3-carboxamide Show/Hide	C19H20N4O3S	2
1	IC50 = 15 nM
2	IC50 = 27 nM
CP0549590 Compound Info	[4-[(4-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino]-3-methoxyphenyl]-(4-methylpiperazin-1-yl)methanone Show/Hide	C21H26N6O3	1
1	IC50 = 15.85 nM
CP0838495 Compound Info	(R)-(4-((4-Ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxyphenyl)(3-methylmorpholino)methanone Show/Hide	C21H25N5O4	1
1	IC50 = 15.85 nM
CP0185411 Compound Info	7-(2-methyl-1,3-thiazol-5-yl)-4-(propan-2-ylamino)quinoline-3-carbonitrile Show/Hide	C17H16N4S	2
1	IC50 = 16 nM
2	IC50 = 23 nM
CP0114275 Compound Info	3-[4-[(3S)-3-methylpiperidin-1-yl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile Show/Hide	C19H19N5	2
1	IC50 = 16 nM
2	IC50 = 49 nM
CP0578424 Compound Info	4-[(3-pyridin-4-yl-1H-indazol-5-yl)amino]benzonitrile Show/Hide	C19H13N5	2
1	IC50 = 16 nM
2	IC50 = 57 nM
CP0554356 Compound Info	N-[5-[(3R)-3-(2-hydroxypropan-2-yl)pyrrolidin-1-yl]-2-(trifluoromethyl)pyridin-3-yl]-6-(1-methylpyrazol-4-yl)pyridine-2-carboxamide Show/Hide	C23H25F3N6O2	1
1	IC50 = 17 nM
CP0568101 Compound Info	(5R)-5-[(6-fluoro-3-pyridin-4-yl-1H-indazol-5-yl)amino]-5,6,7,8-tetrahydronaphthalene-2-carbonitrile Show/Hide	C23H18FN5	2
1	IC50 = 17 nM
2	IC50 = 218 nM
CP0323240 Compound Info	5-[6-[3-(trifluoromethyl)phenyl]sulfanyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]-1,3-thiazole Show/Hide	C15H8F3N5S2	2
1	IC50 = 18 nM
2	IC50 = 74 nM
CP0069325 Compound Info	3-[4-[(2R)-2-methylmorpholin-4-yl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile Show/Hide	C18H17N5O	1
1	IC50 = 18 nM
CP0116372 Compound Info	4-[5-(5-methylpyridin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]morpholine Show/Hide	C16H17N5O	2
1	IC50 = 18 nM
2	IC50 = 30 nM
CP0562897 Compound Info	6-(1-cyclobutylpyrazol-4-yl)-N-[5-[(3R)-3-(2-hydroxypropan-2-yl)pyrrolidin-1-yl]-2-(trifluoromethyl)pyridin-3-yl]pyridine-2-carboxamide Show/Hide	C26H29F3N6O2	1
1	IC50 = 19 nM
CP0065744 Compound Info	4-(dimethylamino)-7-(4-methylsulfonylphenyl)quinoline-3-carbonitrile Show/Hide	C19H17N3O2S	2
1	IC50 = 20 nM
2	IC50 = 27 nM
CP0069328 Compound Info	3-[4-(diethylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile Show/Hide	C17H17N5	2
1	IC50 = 20 nM
2	IC50 = 151 nM
CP0069330 Compound Info	3-[4-[2-(3-methyl-1,2,4-oxadiazol-5-yl)morpholin-4-yl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile Show/Hide	C20H17N7O2	1
1	IC50 = 20 nM
CP0155868 Compound Info	BDBM50396041 Show/Hide	C17H20ClN5O3	2
1	IC50 = 20.3 nM
2	Ki = 3 nM
CP0260860 Compound Info	4-amino-2-[(3-chloro-1-methylpyrazol-4-yl)amino]-7-methyl-6-[(2R)-2-methylpyrrolidin-1-yl]pyrrolo[2,3-d]pyrimidine-5-carbonitrile Show/Hide	C17H20ClN9	2
1	IC50 = 21 nM
2	IC50 = 34 nM
CP0568098 Compound Info	3-[[(3-pyridin-4-yl-1H-indazol-5-yl)amino]methyl]benzonitrile Show/Hide	C20H15N5	2
1	IC50 = 21 nM
2	IC50 = 26 nM
CP0174414 Compound Info	3-thiophen-2-yl-6-[3-(trifluoromethyl)phenyl]sulfanyl-[1,2,4]triazolo[4,3-b]pyridazine Show/Hide	C16H9F3N4S2	2
1	IC50 = 23 nM
2	IC50 = 75 nM
CP0564500 Compound Info	3-[(1S)-1-[(3-pyridin-4-yl-1H-indazol-5-yl)amino]ethyl]benzonitrile Show/Hide	C21H17N5	2
1	IC50 = 23 nM
2	IC50 = 67 nM
CP0184836 Compound Info	2-[6-[3-(trifluoromethyl)phenyl]sulfanyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]-1,3-thiazole Show/Hide	C15H8F3N5S2	2
1	IC50 = 25 nM
2	IC50 = 88 nM
CP0575556 Compound Info	4-amino-7-methyl-2-[[3-methyl-1-(oxetan-3-yl)pyrazol-4-yl]amino]-6-[(2R)-2-methylpyrrolidin-1-yl]pyrrolo[2,3-d]pyrimidine-5-carbonitrile Show/Hide	C20H25N9O	2
1	IC50 = 25 nM
2	IC50 = 38 nM
CP0019480 Compound Info	4-[[(1R)-1-cyclopropylethyl]amino]-7-[4-(2-oxo-1,3-oxazol-3-yl)phenyl]quinoline-3-carbonitrile Show/Hide	C24H20N4O2	2
1	IC50 = 27 nM
2	IC50 = 48 nM
CP0016537 Compound Info	7-(4-methylsulfonylphenyl)-4-(propan-2-ylamino)quinoline-3-carbonitrile Show/Hide	C20H19N3O2S	2
1	IC50 = 28 nM
2	IC50 = 31 nM
CP0069327 Compound Info	4-[5-(3-methoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]morpholine Show/Hide	C17H18N4O2	2
1	IC50 = 28 nM
2	IC50 = 46 nM
CP0357678 Compound Info	N-[2-(3-methoxyazetidin-1-yl)-5-(trifluoromethyl)pyridin-4-yl]-6-(1-methylpyrazol-4-yl)pyridine-2-carboxamide Show/Hide	C20H19F3N6O2	1
1	IC50 = 28 nM
CP0550119 Compound Info	(4R)-4-[[3-(2-methylpyridin-4-yl)-1H-indazol-5-yl]amino]-3,4-dihydro-2H-chromene-7-carbonitrile Show/Hide	C23H19N5O	2
1	IC50 = 29 nM
2	IC50 = 132 nM
CP0231666 Compound Info	5-[6-(3-tert-butylphenyl)sulfanyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]-1,3-thiazole Show/Hide	C18H17N5S2	2
1	IC50 = 30 nM
2	IC50 = 75 nM
CP0260867 Compound Info	4-amino-2-[(1,3-dimethylpyrazol-4-yl)amino]-7-methyl-6-[(2R)-2-methylpyrrolidin-1-yl]pyrrolo[2,3-d]pyrimidine-5-carbonitrile Show/Hide	C18H23N9	4
1	IC50 = 30 nM
2	IC50 = 38 nM
3	Ki = 1 nM
4	Ki = 2 nM
CP0357656 Compound Info	N-(1-cyclobutylpyrazol-4-yl)-2-(1-methylpyrazol-4-yl)pyrimidine-4-carboxamide Show/Hide	C16H17N7O	1
1	IC50 = 34 nM
CP0184815 Compound Info	4-[6-[3-(trifluoromethyl)phenyl]sulfanyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]-1,3-thiazole Show/Hide	C15H8F3N5S2	2
1	IC50 = 35 nM
2	IC50 = 140 nM
CP0355745 Compound Info	4-amino-2-[[1-(2-hydroxy-2-methylpropyl)-5-methylpyrazol-4-yl]amino]-7-methyl-6-[(2R)-2-methylpyrrolidin-1-yl]pyrrolo[2,3-d]pyrimidine-5-carbonitrile Show/Hide	C21H29N9O	2
1	IC50 = 35 nM
2	IC50 = 43 nM
CP0280003 Compound Info	3-[4-[2-(1,2-oxazol-5-yl)morpholin-4-yl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile Show/Hide	C20H16N6O2	1
1	IC50 = 37 nM
CP0344358 Compound Info	4-amino-7-methyl-2-[[5-methyl-1-(oxetan-3-yl)pyrazol-4-yl]amino]-6-[(2R)-2-methylpyrrolidin-1-yl]pyrrolo[2,3-d]pyrimidine-5-carbonitrile Show/Hide	C20H25N9O	2
1	IC50 = 37 nM
2	IC50 = 47 nM
CP0550122 Compound Info	4-[(3-pyridin-4-yl-1H-indazol-5-yl)oxy]benzene-1,3-dicarbonitrile Show/Hide	C20H11N5O	2
1	IC50 = 38 nM
2	IC50 = 48 nM
CP0064440 Compound Info	6-(2,5-dimethoxyphenyl)sulfanyl-3-phenyl-[1,2,4]triazolo[4,3-b]pyridazine Show/Hide	C19H16N4O2S	3
1	IC50 = 40 nM
2	IC50 = 82 nM
3	IC50 = 173 nM
CP0546302 Compound Info	6-(1-ethylpyrazol-4-yl)-N-[5-[(3R)-3-(2-hydroxypropan-2-yl)pyrrolidin-1-yl]-2-(trifluoromethyl)pyridin-3-yl]pyridine-2-carboxamide Show/Hide	C24H27F3N6O2	1
1	IC50 = 40 nM
CP0090034 Compound Info	4-[5-(3-cyanophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]morpholine-2-carbonitrile Show/Hide	C18H14N6O	1
1	IC50 = 42 nM
CP0575874 Compound Info	4-amino-2-[[1-(2-hydroxy-2-methylpropyl)-3-methylpyrazol-4-yl]amino]-7-methyl-6-[(2R)-2-methylpyrrolidin-1-yl]pyrrolo[2,3-d]pyrimidine-5-carbonitrile Show/Hide	C21H29N9O	2
1	IC50 = 42 nM
2	IC50 = 49 nM
CP0550120 Compound Info	N-(3,4-dihydro-2H-chromen-4-yl)-3-pyridin-4-yl-1H-indazol-5-amine Show/Hide	C21H18N4O	2
1	IC50 = 42 nM
2	IC50 = 154 nM
CP0578015 Compound Info	4-amino-2-[(1,5-dimethylpyrazol-4-yl)amino]-7-methyl-6-[(2R)-2-methylpyrrolidin-1-yl]pyrrolo[2,3-d]pyrimidine-5-carbonitrile Show/Hide	C18H23N9	4
1	IC50 = 43 nM
2	IC50 = 75 nM
3	Ki = 2 nM
4	Ki = 3 nM
CP0550117 Compound Info	4-[[(3-pyridin-4-yl-1H-indazol-5-yl)amino]methyl]benzonitrile Show/Hide	C20H15N5	2
1	IC50 = 43 nM
2	IC50 = 48 nM
CP0262506 Compound Info	7-(6-methylsulfonylpyridin-3-yl)-4-(propan-2-ylamino)quinoline-3-carbonitrile Show/Hide	C19H18N4O2S	2
1	IC50 = 48 nM
2	IC50 = 64 nM
CP0174408 Compound Info	2-[(3-thiophen-2-yl-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)sulfanyl]propanamide Show/Hide	C12H11N5OS2	2
1	IC50 = 48 nM
2	IC50 = 98 nM
CP0564490 Compound Info	3-methyl-4-[(3-pyridin-4-yl-1H-indazol-5-yl)oxy]benzonitrile Show/Hide	C20H14N4O	2
1	IC50 = 50 nM
2	IC50 = 134 nM
CP0573477 Compound Info	4-amino-2-[[1-[(3-hydroxyoxetan-3-yl)methyl]-3-methylpyrazol-4-yl]amino]-7-methyl-6-[(2R)-2-methylpyrrolidin-1-yl]pyrrolo[2,3-d]pyrimidine-5-carbonitrile Show/Hide	C21H27N9O2	2
1	IC50 = 51 nM
2	IC50 = 57 nM
CP0568099 Compound Info	(5R)-5-[[3-(2-methoxypyridin-4-yl)-1H-indazol-5-yl]amino]-5,6,7,8-tetrahydronaphthalene-2-carbonitrile Show/Hide	C24H21N5O	2
1	IC50 = 51 nM
2	IC50 = 637 nM
CP0077181 Compound Info	7-(4-methylsulfonylphenyl)-4-piperidin-1-ylquinoline-3-carbonitrile Show/Hide	C22H21N3O2S	2
1	IC50 = 52 nM
2	IC50 = 59 nM
CP0085676 Compound Info	4-[5-(1-methylpyrazol-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]morpholine Show/Hide	C14H16N6O	2
1	IC50 = 53 nM
2	IC50 = 90 nM
CP0535010 Compound Info	N-(1-cyclobutylpyrazol-4-yl)-6-(1-methylpyrazol-4-yl)pyridine-2-carboxamide Show/Hide	C17H18N6O	1
1	IC50 = 53 nM
CP0571222 Compound Info	3-nitro-2-[(3-pyridin-4-yl-1H-indazol-5-yl)amino]benzonitrile Show/Hide	C19H12N6O2	2
1	IC50 = 54 nM
2	IC50 = 118 nM
CP0573658 Compound Info	3-methoxy-2-[(3-pyridin-4-yl-1H-indazol-5-yl)amino]benzonitrile Show/Hide	C20H15N5O	2
1	IC50 = 54 nM
2	IC50 = 156 nM
CP0466116 Compound Info	[4-[(4-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino]-3-methoxyphenyl]-(2-oxa-6-azaspiro[3.3]heptan-6-yl)methanone Show/Hide	C21H23N5O4	1
1	IC50 = 63.1 nM
CP0920744 Compound Info	((2R,6S)-2,6-Dimethylmorpholino)(4-((4-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxyphenyl)methanone Show/Hide	C22H27N5O4	1
1	IC50 = 63.1 nM
CP0052243 Compound Info	5-(2,5-dimethoxyphenyl)sulfanyl-3-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyrimidine Show/Hide	C18H17N5O2S	1
1	IC50 = 64 nM
CP0052246 Compound Info	4-methoxy-3-[[3-(1-methylpyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]sulfanyl]benzonitrile Show/Hide	C17H13N7OS	1
1	IC50 = 64 nM
CP0052255 Compound Info	6-(2,5-dimethoxyphenyl)sulfanyl-3-(1-methylpyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazine Show/Hide	C17H16N6O2S	1
1	IC50 = 64 nM
CP0065790 Compound Info	7-(5-chlorothiophen-2-yl)-4-(propan-2-ylamino)quinoline-3-carbonitrile Show/Hide	C17H14ClN3S	2
1	IC50 = 65 nM
2	IC50 = 109 nM
CP0480455 Compound Info	6-(2,5-dimethoxyphenyl)sulfanyl-3-(5-methoxypyridin-3-yl)-[1,2,4]triazolo[4,3-b]pyridazine Show/Hide	C19H17N5O3S	1
1	IC50 = 66 nM
CP0052244 Compound Info	6-(2,5-dimethoxyphenyl)sulfanyl-3-(1-methylpyrazol-4-yl)imidazo[1,2-b]pyridazine Show/Hide	C18H17N5O2S	1
1	IC50 = 69 nM
CP0069329 Compound Info	3-[4-[(3R)-3-methylpiperidin-1-yl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile Show/Hide	C19H19N5	2
1	IC50 = 69 nM
2	IC50 = 171 nM
CP0574337 Compound Info	N-(1-cyclobutylpyrazol-4-yl)-2-fluoro-3-(1-methylpyrazol-4-yl)benzamide Show/Hide	C18H18FN5O	1
1	IC50 = 70 nM
CP0334641 Compound Info	6-(5-chloro-2-methoxyphenyl)sulfanyl-3-(1-methylpyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazine Show/Hide	C16H13ClN6OS	1
1	IC50 = 78 nM
CP0310490 Compound Info	3-fluoro-5-(4-morpholin-4-yl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)benzonitrile Show/Hide	C17H14FN5O	2
1	IC50 = 80 nM
2	IC50 = 688 nM
CP0546886 Compound Info	4-fluoro-2-[(3-pyridin-4-yl-1H-indazol-5-yl)amino]benzonitrile Show/Hide	C19H12FN5	2
1	IC50 = 81 nM
2	IC50 = 163 nM
CP0275674 Compound Info	5-cyclopropyl-4-N-[2-(1H-imidazol-5-yl)ethyl]-2-N-[3-methyl-1-(2,2,2-trifluoroethyl)pyrazol-4-yl]pyrimidine-2,4-diamine Show/Hide	C18H21F3N8	1
1	IC50 = 89 nM
CP0302713 Compound Info	3-[6-(2,5-dimethoxyphenyl)sulfanyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]-1,2-thiazole Show/Hide	C16H13N5O2S2	1
1	IC50 = 91 nM
CP0379031 Compound Info	5-[6-(2,5-dimethoxyphenyl)sulfanyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]-1,3-thiazole Show/Hide	C16H13N5O2S2	1
1	IC50 = 95 nM
CP0179673 Compound Info	[4-[[4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]-2-fluoro-5-methoxyphenyl]-morpholin-4-ylmethanone Show/Hide	C19H21F4N5O3	3
1	IC50 = 97 nM
2	Ki = 1 nM
3	Ki = 2 nM
CP0158844 Compound Info	5-morpholin-4-yl-2-phenylmethoxy-N-pyridazin-4-ylbenzamide Show/Hide	C22H22N4O3	2
1	IC50 = 100 nM
2	IC50 = 158.49 nM
CP0577653 Compound Info	3-chloro-4-[(3-pyridin-4-yl-1H-indazol-5-yl)amino]benzonitrile Show/Hide	C19H12ClN5	2
1	IC50 = 102 nM
2	IC50 = 227 nM
CP0052242 Compound Info	5-(2,5-dimethoxyphenyl)sulfanyl-2-methyl-3-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyrimidine Show/Hide	C19H19N5O2S	1
1	IC50 = 110 nM
CP0419192 Compound Info	6-(2,5-dimethoxyphenyl)sulfanyl-2-methyl-3-(1-methylpyrazol-4-yl)imidazo[1,2-b]pyridazine Show/Hide	C19H19N5O2S	1
1	IC50 = 115 nM
CP0085675 Compound Info	3-[4-(azetidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile Show/Hide	C16H13N5	2
1	IC50 = 115 nM
2	IC50 = 325 nM
CP0317166 Compound Info	2-fluoro-5-(4-morpholin-4-yl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)benzonitrile Show/Hide	C17H14FN5O	2
1	IC50 = 117 nM
2	IC50 = 920 nM
CP0069323 Compound Info	3-[4-(2,3,3a,4,6,6a-hexahydrofuro[2,3-c]pyrrol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile Show/Hide	C19H17N5O	1
1	IC50 = 139 nM
CP0546880 Compound Info	5-[(3-pyridin-4-yl-1H-indazol-5-yl)amino]naphthalene-2-carbonitrile Show/Hide	C23H15N5	2
1	IC50 = 150 nM
2	IC50 = 527 nM
CP0169053 Compound Info	4-[[[5-bromo-2-[[3-methyl-1-(2,2,2-trifluoroethyl)pyrazol-4-yl]amino]pyrimidin-4-yl]amino]methyl]benzenesulfonamide Show/Hide	C17H17BrF3N7O2S	1
1	IC50 = 159 nM
CP0543311 Compound Info	(5R)-5-[[3-pyridin-4-yl-6-(trifluoromethyl)-1H-indazol-5-yl]amino]-5,6,7,8-tetrahydronaphthalene-2-carbonitrile Show/Hide	C24H18F3N5	2
1	IC50 = 163 nM
2	IC50 = 646 nM
CP0550121 Compound Info	4-[methyl-(3-pyridin-4-yl-1H-indazol-5-yl)amino]benzene-1,3-dicarbonitrile Show/Hide	C21H14N6	2
1	IC50 = 163 nM
2	IC50 = 346 nM
CP0545146 Compound Info	4-methyl-2-[(3-pyridin-4-yl-1H-indazol-5-yl)amino]benzonitrile Show/Hide	C20H15N5	2
1	IC50 = 197 nM
2	IC50 = 276 nM
CP0219174 Compound Info	[3-(dimethylamino)-4-[(4-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino]phenyl]-(4-methylpiperazin-1-yl)methanone Show/Hide	C22H29N7O2	1
1	IC50 = 199.53 nM
CP0090035 Compound Info	3-[4-(1,3,3a,4,6,6a-hexahydrofuro[3,4-c]pyrrol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile Show/Hide	C19H17N5O	1
1	IC50 = 222 nM
CP0248426 Compound Info	6-(2,5-dimethoxyphenyl)sulfanyl-3-(1-methylpyrazol-3-yl)-[1,2,4]triazolo[4,3-b]pyridazine Show/Hide	C17H16N6O2S	1
1	IC50 = 224 nM
CP0334639 Compound Info	6-(2,5-dimethoxyphenoxy)-3-phenyl-[1,2,4]triazolo[4,3-b]pyridazine Show/Hide	C19H16N4O3	1
1	IC50 = 236 nM
CP0245491 Compound Info	6-(2,5-dimethoxyphenyl)sulfanyl-3-pyridin-3-yl-[1,2,4]triazolo[4,3-b]pyridazine Show/Hide	C18H15N5O2S	1
1	IC50 = 242 nM
CP0238014 Compound Info	5-[4-(2-methoxyethyl)piperazin-1-yl]-2-phenylmethoxy-N-pyridazin-4-ylbenzamide Show/Hide	C25H29N5O3	2
1	IC50 = 251.19 nM
2	IC50 = 398.11 nM
CP0052034 Compound Info	US9321748, 12 Show/Hide	C21H26N6O	1
1	IC50 = 300 nM
CP0322344 Compound Info	6-(2,5-dimethoxyphenyl)sulfanyl-3-(1,3-dimethylpyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazine Show/Hide	C18H18N6O2S	1
1	IC50 = 323 nM
CP0344357 Compound Info	4-amino-7-methyl-6-[(2R)-2-methylpyrrolidin-1-yl]-2-[[1-methyl-3-(trifluoromethyl)pyrazol-4-yl]amino]pyrrolo[2,3-d]pyrimidine-5-carbonitrile Show/Hide	C18H20F3N9	2
1	IC50 = 358 nM
2	IC50 = 508 nM
CP0546889 Compound Info	4-methoxy-2-[(3-pyridin-4-yl-1H-indazol-5-yl)amino]benzonitrile Show/Hide	C20H15N5O	2
1	IC50 = 371 nM
2	IC50 = 866 nM
CP0489450 Compound Info	6-(2,5-dichlorophenyl)sulfanyl-3-(1-methylpyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazine Show/Hide	C15H10Cl2N6S	1
1	IC50 = 373 nM
CP0152600 Compound Info	3-nitro-4-[(2-oxo-1,3-dihydrobenzimidazol-5-yl)amino]benzonitrile Show/Hide	C14H9N5O3	4
1	IC50 = 450 nM
2	IC50 = 500 nM
3	IC50 = 3300 nM
4	IC50 = 11100 nM
CP0131134 Compound Info	6-(2,5-dimethoxyphenyl)sulfanyl-3-pyridin-2-yl-[1,2,4]triazolo[4,3-b]pyridazine Show/Hide	C18H15N5O2S	1
1	IC50 = 496 nM
CP0131136 Compound Info	5-(2,5-dimethoxyphenyl)sulfanyl-3-(1-methylpyrazol-4-yl)triazolo[4,5-b]pyridine Show/Hide	C17H16N6O2S	1
1	IC50 = 525 nM
CP0237765 Compound Info	5-(2,5-dimethoxyphenyl)sulfanyl-3-(1-methylpyrazol-4-yl)imidazo[4,5-b]pyridine Show/Hide	C18H17N5O2S	1
1	IC50 = 661 nM
CP0476051 Compound Info	3-[6-(2,5-dimethoxyphenyl)sulfanyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]-1,2-oxazole Show/Hide	C16H13N5O3S	1
1	IC50 = 804 nM
CP0564489 Compound Info	3-nitro-4-[(2-oxo-3-pyridin-4-yl-1H-benzimidazol-5-yl)amino]benzonitrile Show/Hide	C19H12N6O3	2
1	IC50 = 5110 nM
2	IC50 = 10000 nM
CP0019908 Compound Info	BDBM50242742 Show/Hide	C30H40ClN7O3S	2
1	Kd = 0.86 nM
2	Kd = 1.4 nM
CP0170077 Compound Info	[3-methoxy-4-[[4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]phenyl]-morpholin-4-ylmethanone Show/Hide	C18H20F3N5O3	3
1	Ki = 1 nM
2	Ki = 2 nM
3	Ki = 2.7 nM
CP0262172 Compound Info	[4-[[5-bromo-4-(methylamino)pyrimidin-2-yl]amino]-3-methoxyphenyl]-morpholin-4-ylmethanone Show/Hide	C17H20BrN5O3	2
1	Ki = 1 nM
2	Ki = 2 nM
CP0301154 Compound Info	4-[[4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]-2-fluoro-N-(2-hydroxy-2-methylpropyl)-5-methoxybenzamide Show/Hide	C19H23F4N5O3	1
1	Ki = 1 nM
CP0339215 Compound Info	[4-[[4-(cyclopropylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]-2-fluoro-5-methoxyphenyl]-morpholin-4-ylmethanone Show/Hide	C20H21F4N5O3	1
1	Ki = 1 nM
CP0491719 Compound Info	[2,5-dimethoxy-4-[[4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]phenyl]-morpholin-4-ylmethanone Show/Hide	C19H22F3N5O4	1
1	Ki = 1 nM
CP0087577 Compound Info	2-N-(5-fluoro-2-methoxy-4-methylsulfonylphenyl)-4-N-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine Show/Hide	C14H14F4N4O3S	2
1	Ki = 2 nM
2	Ki = 3 nM
CP0087578 Compound Info	[5-methoxy-2-methyl-4-[[4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]phenyl]-morpholin-4-ylmethanone Show/Hide	C19H22F3N5O3	1
1	Ki = 2 nM
CP0179674 Compound Info	[2-chloro-5-methoxy-4-[[4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]phenyl]-morpholin-4-ylmethanone Show/Hide	C18H19ClF3N5O3	1
1	Ki = 2 nM
CP0301156 Compound Info	[5-chloro-2-methoxy-4-[[4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]phenyl]-morpholin-4-ylmethanone Show/Hide	C18H19ClF3N5O3	2
1	Ki = 2 nM
2	Ki = 4 nM
CP0169665 Compound Info	2-[2-methoxy-4-(morpholine-4-carbonyl)anilino]-4-(methylamino)pyrimidine-5-carbonitrile Show/Hide	C18H20N6O3	3
1	Ki = 2.4 nM
2	Ki = 11 nM
3	Ki = 13 nM
CP0349201 Compound Info	[2-fluoro-5-methoxy-4-[[4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]phenyl]-morpholin-4-ylmethanone Show/Hide	C18H19F4N5O3	2
1	Ki = 2.9 nM
2	Ki = 6 nM
CP0086179 Compound Info	[5-chloro-4-[[4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]-2-methoxyphenyl]-morpholin-4-ylmethanone Show/Hide	C19H21ClF3N5O3	2
1	Ki = 3 nM
2	Ki = 3.4 nM
CP0301155 Compound Info	[5-[[4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]-4-methoxypyridin-2-yl]-morpholin-4-ylmethanone Show/Hide	C18H21F3N6O3	1
1	Ki = 3 nM
CP0179672 Compound Info	5-[[4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]-2-(2-hydroxy-2-methylpropyl)-6-methoxy-3H-isoindol-1-one Show/Hide	C20H24F3N5O3	2
1	Ki = 3 nM
2	Ki = 4 nM
CP0267368 Compound Info	[5-fluoro-2-methoxy-4-[[4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]phenyl]-morpholin-4-ylmethanone Show/Hide	C18H19F4N5O3	2
1	Ki = 4.8 nM
2	Ki = 7 nM
CP0301157 Compound Info	[4-[(5-bromo-4-methoxypyrimidin-2-yl)amino]-3-methoxyphenyl]-morpholin-4-ylmethanone Show/Hide	C17H19BrN4O4	1
1	Ki = 5 nM
CP0239078 Compound Info	[5-chloro-2-methyl-4-[[4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]phenyl]-morpholin-4-ylmethanone Show/Hide	C18H19ClF3N5O2	1
1	Ki = 7 nM
CP0061269 Compound Info	2-N-[2-chloro-4-(1-methyltetrazol-5-yl)phenyl]-4-N-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine Show/Hide	C14H12ClF3N8	2
1	Ki = 7 nM
2	Ki = 8 nM
CP0179678 Compound Info	[4-[(5-chloro-4-methoxypyrimidin-2-yl)amino]-3-methoxyphenyl]-morpholin-4-ylmethanone Show/Hide	C17H19ClN4O4	2
1	Ki = 9 nM
2	Ki = 10.4 nM
CP0335187 Compound Info	2-N-[4-methoxy-6-(oxan-4-yl)pyridin-3-yl]-4-N-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine Show/Hide	C17H20F3N5O2	1
1	Ki = 9 nM
CP0339216 Compound Info	[2-fluoro-3-methoxy-4-[[4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]phenyl]-morpholin-4-ylmethanone Show/Hide	C18H19F4N5O3	2
1	Ki = 12 nM
2	Ki = 14.5 nM
CP0087686 Compound Info	[4-[[5-fluoro-4-(methylamino)pyrimidin-2-yl]amino]-3-methoxyphenyl]-morpholin-4-ylmethanone Show/Hide	C17H20FN5O3	2
1	Ki = 58 nM
2	Ki = 71 nM

Clinical Information about the Protein

Target 1 ( Leucine-rich repeat kinase 2 (LRRK2) )

Target Type	Clinical trial Target

Target 2 ( Leucine-rich repeat kinase 2 G2019S mutant (LRRK2 G2019S) )

Target Type	Patented-recorded Target

Target 3 ( Leucine-rich repeat kinase 2 S935 phosphorylation (LRRK2 pS935) )

Target Type	Patented-recorded Target

Target 4 ( Leucine-rich repeat serine/threonine-protein kinase 2 messenger RNA (LRRK2 mRNA) )

Target Type	Clinical trial Target

Similar Protein(s) and Bioactivity Statistics

50% Identity

Protein ID	Protein Name	Protein Organism
PT06768	Leucine-rich repeat serine/threonine-protein kinase 2	Mus musculus, Mouse	Protein Info

Cite

About MolBiC

Correspondence

Prof. Feng ZHU

Prof. Leo, Lianyi Han