Brief Information of the Compound and Protein
Compound Name
 Compound Info 
cis-2,6-Dimethyl-4-(6-(5-(1-methylcyclopropoxy)-1H-indazol-3-yl)pyrimidin-4-yl)morpholine
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 PubChem ID
CID: 78319901
Canonical SMILES
C[C@@H]1CN(c2cc(-c3n[nH]c4ccc(OC5(C)CC5)cc34)ncn2)C[C@H](C)O1
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Compound Formula C21H25N5O2
Compound Structure
Protein Name
 Protein Info 
Leucine-rich repeat serine/threonine-protein kinase 2
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TKL protein kinase group
>
TKL protein kinase LRRK family
Uniprot ID
Q5S007
Gene Name
LRRK2
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  2
1
EC50 = 23 nM
   TI
   LI
   LO
   TS
2
EC50 = 30 nM
   TI
   LI
   LO
   TS
CL000004 SH-SY5Y
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 4.8 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 EC50 ~ 1.22 nM
2 IC50 = 0.4 nM
3 IC50 = 0.5 nM
4 IC50 = 0.76 nM
5 IC50 = 1 nM
6 IC50 ~ 1.8 nM
7 IC50 ~ 3.5 nM
8 IC50 ~ 6.3 nM