Brief Information of the Compound and Protein
Compound Name
[2-fluoro-5-methoxy-4-[[4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]phenyl]-morpholin-4-ylmethanone
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PubChem ID
CID: 58539095
SID: 163502367
Canonical SMILES
CNc1nc(Nc2cc(F)c(cc2OC)C(=O)N2CCOCC2)ncc1C(F)(F)F
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Compound Formula C18H19F4N5O3
Compound Structure
Protein Name
Leucine-rich repeat serine/threonine-protein kinase 2
Protein Classification
Enzyme
>
Kinase
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Protein Kinase
>
TKL protein kinase group
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TKL protein kinase LRRK family
Uniprot ID
Q5S007
Gene Name
LRRK2
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 16 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 2.9 nM
2 Ki = 6 nM