Brief Information of the Compound and Protein
Compound Name
5-methyl-2-[(3-pyridin-4-yl-1H-indazol-5-yl)amino]benzonitrile
    Show/Hide
Canonical SMILES
Cc1ccc(Nc2ccc3[nH]nc(-c4ccncc4)c3c2)c(c1)C#N
    Show/Hide
Compound Formula C20H15N5
Compound Structure
Protein Name
Leucine-rich repeat serine/threonine-protein kinase 2
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TKL protein kinase group
>
TKL protein kinase LRRK family
Uniprot ID
Q5S007
Gene Name
LRRK2
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  2
1
EC50 = 530 nM
   TI
   LI
   LO
   TS
2
EC50 > 100000 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 6 nM
2 IC50 = 18 nM