Brief Information of the Compound and Protein
Compound Name
(4R)-4-[(3-pyridin-4-yl-1H-indazol-5-yl)amino]-3,4-dihydro-2H-chromene-7-carbonitrile
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Canonical SMILES
N#Cc1ccc2[C@@H](CCOc2c1)Nc1ccc2[nH]nc(-c3ccncc3)c2c1
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Compound Formula C22H17N5O
Compound Structure
Protein Name
Leucine-rich repeat serine/threonine-protein kinase 2
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TKL protein kinase group
>
TKL protein kinase LRRK family
Uniprot ID
Q5S007
Gene Name
LRRK2
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  2
1
EC50 = 320 nM
   TI
   LI
   LO
   TS
2
EC50 > 100000 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 8 nM
2 IC50 = 189 nM