| Compound ID |
Compound Name |
Compound Formula |
|
CP0967552
|
(6-((3S,4S)-4-Amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)-3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-5-yl)methanol
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|
C21H24Cl2N6O2
|
1
|
| 1 |
IC50 = 0.4 nM
|
|
|
|
CP0496299
|
US11001561, Compound 74a
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|
C25H26Cl2N4O
|
1
|
| 1 |
IC50 = 2 nM
|
|
|
|
CP0567854
|
[6-[(3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-3-[3-chloro-2-(propylamino)pyridin-4-yl]-2H-pyrazolo[3,4-b]pyrazin-5-yl]methanol
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|
C23H31ClN8O2
|
1
|
| 1 |
IC50 = 2 nM
|
|
|
|
CP0355148
|
US10308660, Example 18
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|
C21H27F3N6OS
|
1
|
| 1 |
IC50 = 4 nM
|
|
|
|
CP0535449
|
US11001561, Compound 109
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|
C25H25Cl2FN4O
|
1
|
| 1 |
IC50 = 4 nM
|
|
|
|
CP0142987
|
US10308660, Example 12
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|
C20H25Cl2N5O2S
|
1
|
| 1 |
IC50 = 5 nM
|
|
|
|
CP0355637
|
US10308660, Example 41
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|
C21H26F4N6OS
|
1
|
| 1 |
IC50 = 5 nM
|
|
|
|
CP0533276
|
US11001561, Compound 119a
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|
C24H24Cl2N4O
|
1
|
| 1 |
IC50 = 5 nM
|
|
|
|
CP0547487
|
US11001561, Compound 66b
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|
C24H25Cl2N5O
|
1
|
| 1 |
IC50 = 5 nM
|
|
|
|
CP0553214
|
US11001561, Compound 81b
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|
C24H24Cl2N4O2
|
1
|
| 1 |
IC50 = 6.6 nM
|
|
|
|
CP0486727
|
US11001561, Compound 110
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|
C26H28ClFN4O
|
1
|
| 1 |
IC50 = 7 nM
|
|
|
|
CP0426096
|
US10308660, Example 32
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|
C22H29ClN6O2S
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0564208
|
(3S,4S)-8-[3-(2,3-dichlorophenyl)-2H-pyrazolo[3,4-b]pyrazin-6-yl]-3-methyl-2-oxa-8-azaspiro[4.5]decan-4-amine
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|
C20H22Cl2N6O
|
2
|
| 1 |
IC50 = 10 nM
|
|
|
| 2 |
IC50 = 31 nM
|
|
|
|
CP0015347
|
Ptpn11 inhibitor tno155
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|
C18H24ClN7OS
|
1
|
| 1 |
IC50 = 11 nM
|
|
|
|
CP0157142
|
6-[(3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-3-(2,3-dichlorophenyl)-5-methyl-2H-pyrazolo[3,4-d]pyrimidin-4-one
Show/Hide
|
C21H24Cl2N6O2
|
1
|
| 1 |
IC50 = 12 nM
|
|
|
|
CP0550467
|
(4R)-8-[5-(2-amino-3-chloropyridin-4-yl)sulfanylpyrazin-2-yl]-8-azaspiro[4.5]decan-4-amine
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|
C18H23ClN6S
|
1
|
| 1 |
IC50 = 13 nM
|
|
|
|
CP0562443
|
6-amino-2-((3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)-3-methyl-5-((2-(trifluoromethyl)pyridin-3-yl)thio)pyrimidin-4(3H)-one
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|
C20H25F3N6O2S
|
1
|
| 1 |
IC50 = 18 nM
|
|
|
|
CP0350674
|
6-[(3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-3-[3-chloro-2-(methylamino)pyridin-4-yl]-5-methyl-2H-pyrazolo[3,4-d]pyrimidin-4-one
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|
C21H27ClN8O2
|
1
|
| 1 |
IC50 = 22 nM
|
|
|
|
CP0571973
|
(3S,4S)-8-[3-[3-chloro-2-(ethylamino)pyridin-4-yl]-2H-pyrazolo[3,4-b]pyrazin-6-yl]-3-methyl-2-oxa-8-azaspiro[4.5]decan-4-amine
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|
C21H27ClN8O
|
1
|
| 1 |
IC50 = 22 nM
|
|
|
|
CP0573031
|
(4R)-8-[6-amino-5-(2-amino-3-chloropyridin-4-yl)sulfanylpyrazin-2-yl]-8-azaspiro[4.5]decan-4-amine
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|
C18H24ClN7S
|
1
|
| 1 |
IC50 = 24 nM
|
|
|
|
CP0344064
|
6-amino-2-[(3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-5-(3-chloro-2-methylpyridin-4-yl)sulfanyl-3-methylpyrimidin-4-one
Show/Hide
|
C20H27ClN6O2S
|
1
|
| 1 |
IC50 = 28 nM
|
|
|
|
CP0550468
|
(3R,4S)-8-[6-amino-5-(2-amino-3-chloropyridin-4-yl)sulfanylpyrazin-2-yl]-3-methyl-2-oxa-8-azaspiro[4.5]decan-4-amine
Show/Hide
|
C18H24ClN7OS
|
1
|
| 1 |
IC50 = 28 nM
|
|
|
|
CP0205180
|
6-[(4R)-4-amino-8-azaspiro[4.5]decan-8-yl]-3-(2,3-dichlorophenyl)-5-methyl-2H-pyrazolo[3,4-d]pyrimidin-4-one
Show/Hide
|
C21H24Cl2N6O
|
1
|
| 1 |
IC50 = 30 nM
|
|
|
|
CP0576320
|
(4R)-8-[3-(2,3-dichlorophenyl)-2H-pyrazolo[3,4-b]pyrazin-6-yl]-8-azaspiro[4.5]decan-4-amine
Show/Hide
|
C20H22Cl2N6
|
1
|
| 1 |
IC50 = 35 nM
|
|
|
|
CP0344056
|
6-[(3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-3-[3-chloro-2-(cyclopropylamino)pyridin-4-yl]-5-methyl-2H-pyrazolo[3,4-d]pyrimidin-4-one
Show/Hide
|
C23H29ClN8O2
|
1
|
| 1 |
IC50 = 36 nM
|
|
|
|
CP0344055
|
6-[(3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-3-(6-amino-2-methylpyridin-3-yl)-5-methyl-2H-pyrazolo[3,4-d]pyrimidin-4-one
Show/Hide
|
C21H28N8O2
|
1
|
| 1 |
IC50 = 38 nM
|
|
|
|
CP0562212
|
(4R)-8-[6-amino-5-[2-(trifluoromethyl)pyridin-3-yl]sulfanylpyrazin-2-yl]-8-azaspiro[4.5]decan-4-amine
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|
C19H23F3N6S
|
1
|
| 1 |
IC50 = 40 nM
|
|
|
|
CP0952246
|
(4S)-8-(3-(2,3-Dichlorophenyl)-1H-pyrazolo[3,4-b]-pyrazin-6-yl-2-oxa-8-azaspiro[4.5]-decan-4-amine
Show/Hide
|
C19H20Cl2N6O
|
1
|
| 1 |
IC50 = 40 nM
|
|
|
|
CP0577997
|
1-(3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-4-methylpiperidin-4-amine
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|
C17H18Cl2N6
|
1
|
| 1 |
IC50 = 47 nM
|
|
|
|
CP0577262
|
US11104675, Example 9
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|
C20H23Cl3N4O2
|
1
|
| 1 |
IC50 = 48 nM
|
|
|
|
CP0575304
|
6-amino-2-(4-(aminomethyl)-4-methylpiperidin-1-yl)-5-((2,3-dichlorophenyl)thio)-3-methylpyrimidin-4(3H)-one
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|
C18H23Cl2N5OS
|
1
|
| 1 |
IC50 = 49 nM
|
|
|
|
CP0574788
|
4-(6-(4-Amino-4-methylpiperidin-1-yl)-1H-pyrazolo[3,4-b]pyrazin-3-yl)-3-chloro-N-methylpyridin-2-amine
Show/Hide
|
C17H21ClN8
|
1
|
| 1 |
IC50 = 64 nM
|
|
|
|
CP0576655
|
6-[4-(aminomethyl)-4-methylpiperidin-1-yl]-3-(2,3-dichlorophenyl)sulfanylpyrazin-2-amine
Show/Hide
|
C17H21Cl2N5S
|
1
|
| 1 |
IC50 = 88 nM
|
|
|
|
CP0560225
|
US10301278, Example 20
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|
C17H23ClN6S
|
1
|
| 1 |
IC50 = 89 nM
|
|
|
|
CP0574958
|
6-(4-amino-4-methylpiperidin-1-yl)-3-(2,3-dichlorophenyl)-2,5-dihydropyrazolo[3,4-d]pyrimidin-4-one
Show/Hide
|
C17H18Cl2N6O
|
1
|
| 1 |
IC50 = 89 nM
|
|
|
|
CP0157144
|
6-[(3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-3-(2,3-dichloropyridin-4-yl)-5-methyl-2H-pyrazolo[3,4-d]pyrimidin-4-one
Show/Hide
|
C20H23Cl2N7O2
|
1
|
| 1 |
IC50 = 93 nM
|
|
|
|
CP0572900
|
6-[(3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-3-(2,3-dichlorophenyl)-5-(hydroxymethyl)-2-methylpyrimidin-4-one
Show/Hide
|
C21H26Cl2N4O3
|
1
|
| 1 |
IC50 = 94 nM
|
|
|
|
CP0556643
|
US10308660, Example 111
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|
C20H24F3N5O2S
|
1
|
| 1 |
IC50 = 96 nM
|
|
|
|
CP0459719
|
3-(2-amino-3-chloropyridin-4-yl)sulfanyl-6-[(3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-5-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-one
Show/Hide
|
C20H25ClN8O2S
|
1
|
| 1 |
IC50 = 96 nM
|
|
|
|
CP0444824
|
US10336774, Example 52
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|
C17H22ClN7OS
|
1
|
| 1 |
IC50 = 99 nM
|
|
|
|
CP0564676
|
3-(2-amino-3-chloropyridin-4-yl)-6-[(3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-5-methyl-2H-pyrazolo[3,4-d]pyrimidin-4-one
Show/Hide
|
C20H25ClN8O2
|
1
|
| 1 |
IC50 = 103 nM
|
|
|
|
CP0157141
|
6-[(4S)-4-amino-2-oxa-8-azaspiro[4.5]decan-8-yl]-3-(2,3-dichlorophenyl)-5-methyl-2H-pyrazolo[3,4-d]pyrimidin-4-one
Show/Hide
|
C20H22Cl2N6O2
|
1
|
| 1 |
IC50 = 123 nM
|
|
|
|
CP0562211
|
3-((2-amino-3-chloropyridin-4-yl)thio)-6-(4-(aminomethyl)-4-methylpiperidin-1-yl)pyrazin-2-amine
Show/Hide
|
C16H22ClN7S
|
1
|
| 1 |
IC50 = 123 nM
|
|
|
|
CP0545325
|
US11001561, Compound 3
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|
C20H24Cl2N4O2
|
1
|
| 1 |
IC50 = 123 nM
|
|
|
|
CP0205181
|
6-[(3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-5-methyl-3-pyridin-4-yl-2H-pyrazolo[3,4-d]pyrimidin-4-one
Show/Hide
|
C20H25N7O2
|
1
|
| 1 |
IC50 = 129 nM
|
|
|
|
CP0573030
|
6-(4-(aminomethyl)-4-methylpiperidin-1-yl)-3-((2-(trifluoromethyl)pyridin-3-yl)thio)pyrazin-2-amine
Show/Hide
|
C17H21F3N6S
|
1
|
| 1 |
IC50 = 187 nM
|
|
|
|
CP0322543
|
6-(4-amino-4-methylpiperidin-1-yl)-3-(2,3-dichlorophenyl)sulfanylpyrazin-2-amine
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|
C16H19Cl2N5S
|
1
|
| 1 |
IC50 = 195 nM
|
|
|
|
CP0576447
|
4-[(3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-1-(2,3-dichlorophenyl)-2-methyl-6-oxopyrimidine-5-carboxamide
Show/Hide
|
C21H25Cl2N5O3
|
1
|
| 1 |
IC50 = 223 nM
|
|
|
|
CP0720691
|
6-(4-amino-4-methylpiperidin-1-yl)-3-(2,3-dichlorophenyl)pyrazin-2-amine
Show/Hide
|
C16H19Cl2N5
|
1
|
| 1 |
IC50 = 250 nM
|
|
|
|
CP0537596
|
US10301278, Example 2
Show/Hide
|
C16H20ClN5S
|
1
|
| 1 |
IC50 = 251 nM
|
|
|
|
CP0459717
|
6-[(3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-3-[3-chloro-2-(cyclobutylamino)pyridin-4-yl]-5-methyl-2H-pyrazolo[3,4-d]pyrimidin-4-one
Show/Hide
|
C24H31ClN8O2
|
1
|
| 1 |
IC50 = 260 nM
|
|
|
|
CP0562846
|
US10301278, Example 30
Show/Hide
|
C16H19F3N6S
|
1
|
| 1 |
IC50 = 339 nM
|
|
|
|
CP0350673
|
6-[4-(aminomethyl)-4-methylpiperidin-1-yl]-3-(2,3-dichlorophenyl)-5-methyl-2H-pyrazolo[3,4-d]pyrimidin-4-one
Show/Hide
|
C19H22Cl2N6O
|
1
|
| 1 |
IC50 = 355 nM
|
|
|
|
CP0838509
|
6-(4-(aminomethyl)-4-methylpiperidin-1-yl)-3-(2,3-dichlorophenyl)pyrazin-2-amine
Show/Hide
|
C17H21Cl2N5
|
1
|
| 1 |
IC50 = 357 nM
|
|
|
|
CP0157143
|
(3S,4S)-8-[7-(2,3-dichlorophenyl)-5H-pyrrolo[2,3-b]pyrazin-3-yl]-3-methyl-2-oxa-8-azaspiro[4.5]decan-4-amine
Show/Hide
|
C21H23Cl2N5O
|
1
|
| 1 |
IC50 = 484 nM
|
|
|
|
CP0567855
|
US11001561, Compound 2
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|
C17H20Cl2N4O
|
1
|
| 1 |
IC50 = 557 nM
|
|
|
|
CP0487904
|
3-(4-amino-4-methylpiperidin-1-yl)-6-(2,3-dichlorophenyl)-1,2,4-triazin-5-amine
Show/Hide
|
C15H18Cl2N6
|
1
|
| 1 |
IC50 = 620 nM
|
|
|
|
CP0571051
|
US11001561, Compound 24
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|
C21H23Cl2F3N4O2
|
1
|
| 1 |
IC50 = 625 nM
|
|
|
|
CP0137285
|
6-(4-amino-4-methylpiperidin-1-yl)-3-(2,3-dichlorophenyl)-5-methyl-2H-pyrazolo[3,4-d]pyrimidin-4-one
Show/Hide
|
C18H20Cl2N6O
|
1
|
| 1 |
IC50 = 746 nM
|
|
|
|
CP0715133
|
2-((3S,4S)-4-Amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)-5-((2-(trifluoromethyl)pyridin-3-yl)thio)pyrimidin-4(3H)-one
Show/Hide
|
C19H22F3N5O2S
|
1
|
| 1 |
IC50 = 1060 nM
|
|
|
|
CP0322544
|
(4S)-8-[6-amino-5-[2-(trifluoromethyl)pyridin-3-yl]sulfanylpyrazin-2-yl]-8-azaspiro[4.5]decan-4-amine
Show/Hide
|
C19H23F3N6S
|
1
|
| 1 |
IC50 = 1800 nM
|
|
|
|
CP0540680
|
2-(4-amino-4-methylpiperidin-1-yl)-5-(2,3-dichlorophenyl)pyrimidin-4-amine
Show/Hide
|
C16H19Cl2N5
|
1
|
| 1 |
IC50 = 1980 nM
|
|
|
|
CP0545324
|
4-[(3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-1-(2,3-dichlorophenyl)-2-methyl-6-oxopyrimidine-5-carbonitrile
Show/Hide
|
C21H23Cl2N5O2
|
1
|
| 1 |
IC50 = 3081 nM
|
|
|
|
CP0439943
|
Tert-butyl ((1-(4-((4-methoxybenzyl)oxy)pyrimidin-2-yl)-4-methylpiperidin-4-yl)methyl)carbamate
Show/Hide
|
C17H20F3N5OS
|
1
|
| 1 |
IC50 > 2000 nM
|
|
|
