General Information of the Compound
Compound ID
CP0487904
Compound Name
3-(4-amino-4-methylpiperidin-1-yl)-6-(2,3-dichlorophenyl)-1,2,4-triazin-5-amine
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Structure
Formula
C15H18Cl2N6
Molecular Weight
353.257
Canonical SMILES
CC1(N)CCN(CC1)c1nnc(c(N)n1)-c1cccc(Cl)c1Cl
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InChI
InChI=1S/C15H18Cl2N6/c1-15(19)5-7-23(8-6-15)14-20-13(18)12(21-22-14)9-3-2-4-10(16)11(9)17/h2-4H,5-8,19H2,1H3,(H2,18,20,22)
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InChIKey
VTTSGEFPLPXNHH-UHFFFAOYSA-N
Physicochemical Property
logP
2.7452
Rotatable Bonds
2
Heavy Atom Count
23
Polar Areas
93.95
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
6
Complexity
23

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 118239663
ChEMBL ID
CHEMBL4540461
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01346, Tyrosine-protein phosphatase non-receptor type 11
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000269 KYSE-520 Homo sapiens (Human)  1
1
IC50 = 620 nM
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