General Information of the Cell Line
Cell Line ID
CL000269
Cell Line Name
KYSE-520
Synonyms
KYSE 520
KYSE520
Kyse520
KYSE0520
Category
Cancer cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_1355
Tissue Information
Esophagus
Disease
Esophageal squamous cell carcinoma (NCIt: C4024)
Squamous cell carcinoma of the esophagus (ORDO: Orphanet_99977)
Map of Molecular Bioactivity Related to the Cell Line
Map of Molecular Bioactivity Related to the Cell Line

Cell Line
Protein
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Cell Line
Protein ID: PT00922, Epidermal growth factor receptor
 Protein Info 
Compound ID Compound Name Compound Formula
CP0037987
 Compound Info 
N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine
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C22H23N3O4
  1
1
IC50 = 15 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Protein ID: PT01346, Tyrosine-protein phosphatase non-receptor type 11
 Protein Info 
Cell Viability or Cytotoxicity Assay
Compound ID Compound Name Compound Formula
CP0157141
 Compound Info 
6-[(4S)-4-amino-2-oxa-8-azaspiro[4.5]decan-8-yl]-3-(2,3-dichlorophenyl)-5-methyl-2H-pyrazolo[3,4-d]pyrimidin-4-one
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 C20H22Cl2N6O2  1
1
IC50 = 1730 nM
   TI
   LI
   LO
   TS
CP0205180
 Compound Info 
6-[(4R)-4-amino-8-azaspiro[4.5]decan-8-yl]-3-(2,3-dichlorophenyl)-5-methyl-2H-pyrazolo[3,4-d]pyrimidin-4-one
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 C21H24Cl2N6O  1
1
IC50 = 465 nM
   TI
   LI
   LO
   TS
CP0322543
 Compound Info 
6-(4-amino-4-methylpiperidin-1-yl)-3-(2,3-dichlorophenyl)sulfanylpyrazin-2-amine
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 C16H19Cl2N5S  1
1
IC50 = 4070 nM
   TI
   LI
   LO
   TS
CP0350673
 Compound Info 
6-[4-(aminomethyl)-4-methylpiperidin-1-yl]-3-(2,3-dichlorophenyl)-5-methyl-2H-pyrazolo[3,4-d]pyrimidin-4-one
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 C19H22Cl2N6O  1
1
IC50 = 13490 nM
   TI
   LI
   LO
   TS
CP0426096
 Compound Info 
US10308660, Example 32
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 C22H29ClN6O2S  1
1
IC50 = 295 nM
   TI
   LI
   LO
   TS
CP0439943
 Compound Info 
Tert-butyl ((1-(4-((4-methoxybenzyl)oxy)pyrimidin-2-yl)-4-methylpiperidin-4-yl)methyl)carbamate
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 C17H20F3N5OS  1
1
IC50 > 2000 nM
   TI
   LI
   LO
   TS
CP0459717
 Compound Info 
6-[(3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-3-[3-chloro-2-(cyclobutylamino)pyridin-4-yl]-5-methyl-2H-pyrazolo[3,4-d]pyrimidin-4-one
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 C24H31ClN8O2  1
1
IC50 = 380 nM
   TI
   LI
   LO
   TS
CP0537596
 Compound Info 
US10301278, Example 2
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 C16H20ClN5S  1
1
IC50 = 8140 nM
   TI
   LI
   LO
   TS
CP0573031
 Compound Info 
(4R)-8-[6-amino-5-(2-amino-3-chloropyridin-4-yl)sulfanylpyrazin-2-yl]-8-azaspiro[4.5]decan-4-amine
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 C18H24ClN7S  1
1
IC50 = 123 nM
   TI
   LI
   LO
   TS
CP0575304
 Compound Info 
6-amino-2-(4-(aminomethyl)-4-methylpiperidin-1-yl)-5-((2,3-dichlorophenyl)thio)-3-methylpyrimidin-4(3H)-one
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 C18H23Cl2N5OS  1
1
IC50 = 273 nM
   TI
   LI
   LO
   TS
CP0576655
 Compound Info 
6-[4-(aminomethyl)-4-methylpiperidin-1-yl]-3-(2,3-dichlorophenyl)sulfanylpyrazin-2-amine
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 C17H21Cl2N5S  1
1
IC50 = 2670 nM
   TI
   LI
   LO
   TS
Protein family and CMB statistics Related to the Cell Line
Cell Lines Derived from the same Tissue Source (Esophagus)
Cell Line Name Organism Disease
OE33
 Cell Line Info 
Homo sapiens (Human) Barrett adenocarcinoma
SK-GT-4
 Cell Line Info 
Homo sapiens (Human) Esophageal adenocarcinoma
OE19
 Cell Line Info 
Homo sapiens (Human) Esophageal adenocarcinoma
KYSE-150
 Cell Line Info 
Homo sapiens (Human) Esophageal squamous cell carcinoma