General Information of the Protein
Protein ID
PT01346
Protein Name
Tyrosine-protein phosphatase non-receptor type 11
Secondarily
Protein Name
Protein-tyrosine phosphatase 1D
Protein-tyrosine phosphatase 2C
SH-PTP2
SH-PTP3
Gene Name
PTPN11
Secondarily
Gene Name
PTP2C
SHPTP2
Sequence
MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
>
Phosphatase
>
Protein Phosphatase
>
Tyrosine protein phosphatase
Function
Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus (PubMed:10655584, PubMed:18559669, PubMed:18829466, PubMed:26742426, PubMed:28074573). Positively regulates MAPK signal transduction pathway (PubMed:28074573). Dephosphorylates GAB1, ARHGAP35 and EGFR (PubMed:28074573). Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulation of its RhoA binding activity (PubMed:18559669). Dephosphorylates CDC73 (PubMed:26742426). Dephosphorylates SOX9 on tyrosine residues, leading to inactivate SOX9 and promote ossification (By similarity). Dephosphorylates tyrosine-phosphorylated NEDD9/CAS-L (PubMed:19275884).
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Uniprot ID
Primary ID:
Q06124

Secondarily ID:
A8K1D9
Q96HD7
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Ensembl ID
ENSG00000179295
HGNC ID
HGNC:9644
Subcellular Location
Cytoplasm
Nucleus
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000434 , KG-1
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0384556
 Compound Info 
(2E)-3-{3-chloro-4-[3-(3,3-dimethylbut-1-yn-1-yl)-4-hydroxyphenyl]phenyl}prop-2-enoic acid
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C21H19ClO3
  1
1
IC50 = 450 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0095649
 Compound Info 
(2E)-3-{4-[3-(adamantan-1-yl)-4-aminophenyl]-3-chlorophenyl}prop-2-enoic acid
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C25H26ClNO2
  1
1
IC50 = 1830 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0052426
 Compound Info 
(2E)-3-{4-[3-(adamantan-1-yl)-4-hydroxyphenyl]-3-chlorophenyl}prop-2-enoic acid
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C25H25ClO3
  1
1
IC50 = 2100 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0166875
 Compound Info 
(2E)-3-{4-[3-(adamantan-1-yl)-4-fluorophenyl]-3-chlorophenyl}prop-2-enoic acid
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C25H24ClFO2
  1
1
IC50 = 2110 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0206772
 Compound Info 
(2E)-3-{3-chloro-4-[3-(3,5-dimethyladamantan-1-yl)-4-hydroxyphenyl]phenyl}prop-2-enoic acid
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C27H29ClO3
  1
1
IC50 = 2270 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0503035
 Compound Info 
(2E)-3-[3-chloro-4-(4-hydroxy-3-{tricyclo[3.3.1.0^{3,7}]nonan-3-yl}phenyl)phenyl]prop-2-enoic acid
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C24H23ClO3
  1
1
IC50 = 3910 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0247307
 Compound Info 
(2E)-3-{4-[3-(adamantan-1-yl)-4-acetamidophenyl]-3-chlorophenyl}prop-2-enoic acid
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C27H28ClNO3
  1
1
IC50 = 4550 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0064470
 Compound Info 
(2E)-3-{3-chloro-4-[3-(3-ethylpentan-3-yl)-4-hydroxyphenyl]phenyl}prop-2-enoic acid
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C22H25ClO3
  1
1
IC50 = 5370 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0373216
 Compound Info 
(2E)-3-{3-chloro-4-[4-hydroxy-3-(1-methylcyclohexyl)phenyl]phenyl}prop-2-enoic acid
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C22H23ClO3
  1
1
IC50 = 6400 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0526919
 Compound Info 
(2E)-3-{3-chloro-4-[4-hydroxy-3-(2-methyl-1,3-dithian-2-yl)phenyl]phenyl}prop-2-enoic acid
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C20H19ClO3S2
  1
1
IC50 = 10200 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0484751
 Compound Info 
(2E)-3-{3-chloro-4-[3-(2,6-dimethylphenyl)-4-hydroxyphenyl]phenyl}prop-2-enoic acid
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C23H19ClO3
  1
1
IC50 = 19900 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Cell Line ID: CL000269 , KYSE-520
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0471504
 Compound Info 
(S)-6-(((1-(tert-butyl)-1H-1,2,3- triazol-4-yl)(6-fluoropyridin-3- yl)methyl-d)amino)-8-chloro-4- (neopentylamino)quinoline-3- carbonitrile
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C21H26Cl2N4O2
  1
1 IC50 = 1.5 nM
CP0015347
 Compound Info 
Ptpn11 inhibitor tno155
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C18H24ClN7OS
  2
1 IC50 = 3.8 nM
2 IC50 = 11 nM
CP0577997
 Compound Info 
1-(3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-4-methylpiperidin-4-amine
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C17H18Cl2N6
  2
1 IC50 = 15.7 nM
2 Kd = 49 nM
CP0562443
 Compound Info 
6-amino-2-((3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)-3-methyl-5-((2-(trifluoromethyl)pyridin-3-yl)thio)pyrimidin-4(3H)-one
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C20H25F3N6O2S
  1
1 IC50 = 23 nM
CP0576655
 Compound Info 
6-[4-(aminomethyl)-4-methylpiperidin-1-yl]-3-(2,3-dichlorophenyl)sulfanylpyrazin-2-amine
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C17H21Cl2N5S
  6
1 IC50 = 23 nM
2 IC50 > 10000 nM
3 Ki = 22 nM
4 Km = 95380 nM
5 Km = 103200 nM
6 Km = 141600 nM
CP0322543
 Compound Info 
6-(4-amino-4-methylpiperidin-1-yl)-3-(2,3-dichlorophenyl)sulfanylpyrazin-2-amine
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C16H19Cl2N5S
  2
1 IC50 = 25 nM
2 IC50 > 10000 nM
CP0344056
 Compound Info 
6-[(3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-3-[3-chloro-2-(cyclopropylamino)pyridin-4-yl]-5-methyl-2H-pyrazolo[3,4-d]pyrimidin-4-one
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C23H29ClN8O2
  1
1 IC50 = 36 nM
CP0720691
 Compound Info 
6-(4-amino-4-methylpiperidin-1-yl)-3-(2,3-dichlorophenyl)pyrazin-2-amine
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C16H19Cl2N5
  9
1 IC50 = 39.7 nM
2 IC50 = 70 nM
3 IC50 = 71 nM
4 IC50 = 136.2 nM
5 IC50 > 10000 nM
6 Ki = 67 nM
7 Km = 89330 nM
8 Km = 90170 nM
9 Km = 135700 nM
CP0537596
 Compound Info 
US10301278, Example 2
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C16H20ClN5S
  3
1 IC50 = 70 nM
2 IC50 = 98 nM
3 IC50 > 10000 nM
Clinical Information about the Protein
Target 1 ( Protein-tyrosine phosphatase SHP-2 (PTPN11) )
Target Type Clinical trial Target