General Information of the Compound
Compound ID
CP0486727
Compound Name
US11001561, Compound 110
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Structure
Formula
C26H28ClFN4O
Molecular Weight
466.988
Canonical SMILES
Cc1nc(N2CCC3(Cc4ccccc4[C@H]3N)CC2)c(C)c(=O)n1-c1ccc(F)c(C)c1Cl
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InChI
InChI=1S/C26H28ClFN4O/c1-15-20(28)8-9-21(22(15)27)32-17(3)30-24(16(2)25(32)33)31-12-10-26(11-13-31)14-18-6-4-5-7-19(18)23(26)29/h4-9,23H,10-14,29H2,1-3H3/t23-/m1/s1
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InChIKey
BYKSWQDZGGRHMR-HSZRJFAPSA-N
Physicochemical Property
logP
4.79296
Rotatable Bonds
2
Heavy Atom Count
33
Polar Areas
64.15
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
5
Complexity
33

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 155165225
ChEMBL ID
CHEMBL4764184
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01346, Tyrosine-protein phosphatase non-receptor type 11
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000269 KYSE-520 Homo sapiens (Human)  1
1
IC50 = 7 nM
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